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Klaus kaestner

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Rieck Sebastian; White Peter; Schug Jonathan; Fox Alan J; Smirnova Olga; Gao Nan; Gupta Rana K; Wang Zhao V; Scherer Philipp E; Keller Mark P; Attie Alan D; Kaestner Klaus H
The transcriptional response of the islet to pregnancy in mice.
Tuteja Geetu; White Peter; Schug Jonathan; Kaestner Klaus H
Extracting transcription factor targets from ChIP-Seq data.
Godmann Maren; Gashaw Isabella; Katz Jonathan P; Nagy Andras; Kaestner Klaus H; Behr Rüdiger
Krüppel-like factor 4, a "pluripotency transcription factor" highly expressed in male postmeiotic germ cells, is dispensable for spermatogenesis in the mouse.

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All Publications

2009: Rieck Sebastian; White Peter; Schug Jonathan; Fox Alan J; Smirnova Olga; Gao Nan; Gupta Rana K; Wang Zhao V; Scherer Philipp E; Keller Mark P; Attie Alan D; Kaestner Klaus H
The transcriptional response of the islet to pregnancy in mice.
Molecular endocrinology (Baltimore, Md.) 2009;23(10):1702-12.
2009: Tuteja Geetu; White Peter; Schug Jonathan; Kaestner Klaus H
Extracting transcription factor targets from ChIP-Seq data.
Nucleic acids research 2009;37(17):e113.
2009: Godmann Maren; Gashaw Isabella; Katz Jonathan P; Nagy Andras; Kaestner Klaus H; Behr Rüdiger
Krüppel-like factor 4, a "pluripotency transcription factor" highly expressed in male postmeiotic germ cells, is dispensable for spermatogenesis in the mouse.
Mechanisms of development 2009;126(8-9):650-64.
2009: Golson Maria L; Le Lay John; Gao Nan; Brämswig Nuria; Loomes Kathleen M; Oakey Rebecca; May Catherine L; White Peter; Kaestner Klaus H
Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.
Mechanisms of development 2009;126(8-9):687-99.
2009: Spence Jason R; Lange Alex W; Lin Suh-Chin J; Kaestner Klaus H; Lowy Andrew M; Kim Injune; Whitsett Jeffrey A; Wells James M
Sox17 regulates organ lineage segregation of ventral foregut progenitor cells.
Developmental cell 2009;17(1):62-74.
2009: Le Lay John; Tuteja Geetu; White Peter; Dhir Ravindra; Ahima Rexford; Kaestner Klaus H
CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis.
Cell metabolism 2009;10(1):55-62.
2009: High Frances A; Jain Rajan; Stoller Jason Z; Antonucci Nicole B; Lu Min Min; Loomes Kathleen M; Kaestner Klaus H; Pear Warren S; Epstein Jonathan A
Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development.
The Journal of clinical investigation 2009;119(7):1986-96.
2009: Oliver-Krasinski Jennifer M; Kasner Margaret T; Yang Juxiang; Crutchlow Michael F; Rustgi Anil K; Kaestner Klaus H; Stoffers Doris A
The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.
The Journal of clinical investigation 2009;119(7):1888-98.
2009: Bochkis Irina M; Schug Jonathan; Rubins Nir E; Chopra Atul R; O'Malley Bert W; Kaestner Klaus H
Foxa2-dependent hepatic gene regulatory networks depend on physiological state.
Physiological genomics 2009;38(2):186-95.
2009: Li Zhaoyu; White Peter; Tuteja Geetu; Rubins Nir; Sackett Sara; Kaestner Klaus H
Foxa1 and Foxa2 regulate bile duct development in mice.
The Journal of clinical investigation 2009;119(6):1537-45.
2009: Golson Maria L; Loomes Kathleen M; Oakey Rebecca; Kaestner Klaus H
Ductal malformation and pancreatitis in mice caused by conditional Jag1 deletion.
Gastroenterology 2009;136(5):1761-71.e1.
2009: Gao Nan; White Peter; Kaestner Klaus H
Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2.
Developmental cell 2009;16(4):588-99.
2009: Sackett Sara D; Li Zhaodong; Hurtt Reginald; Gao Yan; Wells Rebecca G; Brondell Karrie; Kaestner Klaus H; Greenbaum Linda E
Foxl1 is a marker of bipotential hepatic progenitor cells in mice.
Hepatology (Baltimore, Md.) 2009;49(3):920-9.
2009: Li Lie; Oropeza Claudia E; Kaestner Klaus H; McLachlan Alan
Limited effects of fasting on hepatitis B virus (HBV) biosynthesis in HBV transgenic mice.
Journal of virology 2009;83(4):1682-8.
2009: Madison Blair B; McKenna Lindsay B; Dolson Diane; Epstein Douglas J; Kaestner Klaus H
FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine.
The Journal of biological chemistry 2009;284(9):5936-44.
2008: Gao Nan; LeLay John; Vatamaniuk Marko Z; Rieck Sebastian; Friedman Joshua R; Kaestner Klaus H
Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.
Genes & development 2008;22(24):3435-48.
2008: Hinoi Eiichi; Gao Nan; Jung Dae Young; Yadav Vijay; Yoshizawa Tatsuya; Myers Martin G; Chua Streamson C; Kim Jason K; Kaestner Klaus H; Karsenty Gerard
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity.
The Journal of cell biology 2008;183(7):1235-42.
2008: Kaestner Klaus H
A two-step pathway to resist fasting.
Cell metabolism 2008;8(6):449-51.
2008: Alenghat Theresa; Meyers Katherine; Mullican Shannon E; Leitner Kirstin; Adeniji-Adele Adetoun; Avila Jacqueline; Bucan Maja; Ahima Rexford S; Kaestner Klaus H; Lazar Mitchell A
Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology.
Nature 2008;456(7224):997-1000.
2008: Gkretsi Vasiliki; Apte Udayan; Mars Wendy M; Bowen William C; Luo Jian-Hua; Yang Yu; Yu Yan P; Orr Ann; St-Arnaud René; Dedhar Shoukat; Kaestner Klaus H; Wu Chuanyue; Michalopoulos George K
Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly.
Hepatology (Baltimore, Md.) 2008;48(6):1932-41.
2008: Bochkis Irina M; Rubins Nir E; White Peter; Furth Emma E; Friedman Joshua R; Kaestner Klaus H
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.
Nature medicine 2008;14(8):828-36.
2008: Mullany Lisa K; White Peter; Hanse Eric A; Nelsen Christopher J; Goggin Melissa M; Mullany Joseph E; Anttila Chelsea K; Greenbaum Linda E; Kaestner Klaus H; Albrecht Jeffrey H
Distinct proliferative and transcriptional effects of the D-type cyclins in vivo.
Cell cycle (Georgetown, Tex.) 2008;7(14):2215-24.
2008: Tuteja Geetu; Jensen Shane T; White Peter; Kaestner Klaus H
Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site.
Nucleic acids research 2008;36(12):4149-57.
2008: Yoshida Tadashi; Kaestner Klaus H; Owens Gary K
Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury.
Circulation research 2008;102(12):1548-57.
2008: Tan Xinping; Yuan Youzhong; Zeng Gang; Apte Udayan; Thompson Michael D; Cieply Benjamin; Stolz Donna B; Michalopoulos George K; Kaestner Klaus H; Monga Satdarshan P S
Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development.
Hepatology (Baltimore, Md.) 2008;47(5):1667-79.
2008: Yusuf Isharat; Kharas Michael G; Chen Jing; Peralta Raechel Q; Maruniak Autumn; Sareen Pratibha; Yang Vincent W; Kaestner Klaus H; Fruman David A
KLF4 is a FOXO target gene that suppresses B cell proliferation.
International immunology 2008;20(5):671-81.
2008: Berkowitz Karen M; Kaestner Klaus H; Jongens Thomas A
Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast.
Molecular human reproduction 2008;14(3):143-50.
2008: Godmann Maren; Katz Jonathan P; Guillou Florian; Simoni Manuela; Kaestner Klaus H; Behr Rüdiger
Krüppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells.
Developmental biology 2008;315(2):552-66.
2008: White Peter; May Catherine Lee; Lamounier Rodrigo N; Brestelli John E; Kaestner Klaus H
Defining pancreatic endocrine precursors and their descendants.
Diabetes 2008;57(3):654-68.
2008: High Frances A; Lu Min Min; Pear Warren S; Loomes Kathleen M; Kaestner Klaus H; Epstein Jonathan A
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):1955-9.
2007: Keller David M; McWeeney Shannon; Arsenlis Athanasios; Drouin Jacques; Wright Christopher V E; Wang Haiyan; Wollheim Claes B; White Peter; Kaestner Klaus H; Goodman Richard H
Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy.
The Journal of biological chemistry 2007;282(44):32084-92.
2007: Tuteja Geetu; Kaestner Klaus H
Forkhead transcription factors II.
Cell 2007;131(1):192.
2007: Gao Nan; White Peter; Doliba Nicolai; Golson Maria L; Matschinsky Franz M; Kaestner Klaus H
Foxa2 controls vesicle docking and insulin secretion in mature Beta cells.
Cell metabolism 2007;6(4):267-79.
2007: Klaewsongkram Jettanong; Yang Yinhua; Golech Susanne; Katz Jonathan; Kaestner Klaus H; Weng Nan-Ping
Krüppel-like factor 4 regulates B cell number and activation-induced B cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4679-84.
2007: Tuteja Geetu; Kaestner Klaus H
SnapShot: forkhead transcription factors I.
Cell 2007;130(6):1160.
2007: Kaestner Klaus H
Beta cell transplantation and immunosuppression: can't live with it, can't live without it.
The Journal of clinical investigation 2007;117(9):2380-2.
2007: Feinberg Mark W; Wara Akm Khyrul; Cao Zhuoxiao; Lebedeva Maria A; Rosenbauer Frank; Iwasaki Hiromi; Hirai Hideyo; Katz Jonathan P; Haspel Richard L; Gray Susan; Akashi Koichi; Segre Julie; Kaestner Klaus H; Tenen Daniel G; Jain Mukesh K
The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation.
The EMBO journal 2007;26(18):4138-48.
2007: Ghaleb Amr M; McConnell Beth B; Nandan Mandayam O; Katz Jonathan P; Kaestner Klaus H; Yang Vincent W
Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis.
Cancer research 2007;67(15):7147-54.
2007: Sackett Sara D; Fulmer James T; Friedman Joshua R; Kaestner Klaus H
Foxl1-Cre BAC transgenic mice: a new tool for gene ablation in the gastrointestinal mesenchyme.
Genesis (New York, N.Y. : 2000) 2007;45(8):518-22.
2007: Hunter Michael P; Wilson Christine M; Jiang Xiaobing; Cong Rong; Vasavada Hemaxi; Kaestner Klaus H; Bogue Clifford W
The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis.
Developmental biology 2007;308(2):355-67.
2007: Behr Rüdiger; Sackett Sara D; Bochkis Irina M; Le Phillip Phuc; Kaestner Klaus H
Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3.
Developmental biology 2007;306(2):636-45.
2007: Apte Udayan; Zeng Gang; Thompson Michael D; Muller Peggy; Micsenyi Amanda; Cieply Benjamin; Kaestner Klaus H; Monga Satdarshan P S
beta-Catenin is critical for early postnatal liver growth.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(6):G1578-85.
2007: Gupta Rana K; Gao Nan; Gorski Regina K; White Peter; Hardy Olga T; Rafiq Kiran; Brestelli John E; Chen Guang; Stoeckert Christian J; Kaestner Klaus H
Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha.
Genes & development 2007;21(7):756-69.
2007: Ku Hsun Teresa; Chai Jing; Kim Yoon-Jung; White Peter; Purohit-Ghelani Sheetal; Kaestner Klaus H; Bromberg Jonathan S
Insulin-expressing colonies developed from murine embryonic stem cell-derived progenitors.
Diabetes 2007;56(4):921-9.
2007: Ghaleb A M; Katz J P; Kaestner K H; Du J X; Yang V W
Krüppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage.
Oncogene 2007;26(16):2365-73.
2007: Hardy Olga T; Hohmeier Hans E; Becker Thomas C; Manduchi Elisabetta; Doliba Nicolai M; Gupta Rana K; White Peter; Stoeckert Christian J; Matschinsky Franz M; Newgard Christopher B; Kaestner Klaus H
Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.
Molecular endocrinology (Baltimore, Md.) 2007;21(3):765-73.
2007: Loomes Kathleen M; Russo Pierre; Ryan Matthew; Nelson Anthony; Underkoffler Lara; Glover Curtis; Fu Hong; Gridley Thomas; Kaestner Klaus H; Oakey Rebecca J
Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage.
Hepatology (Baltimore, Md.) 2007;45(2):323-30.
2007: Mazzarelli Joan M; Brestelli John; Gorski Regina K; Liu Junmin; Manduchi Elisabetta; Pinney Deborah F; Schug Jonathan; White Peter; Kaestner Klaus H; Stoeckert Christian J
EPConDB: a web resource for gene expression related to pancreatic development, beta-cell function and diabetes.
Nucleic acids research 2007;35(Database issue):D751-5.
2007: Swamynathan Shivalingappa K; Katz Jonathan P; Kaestner Klaus H; Ashery-Padan Ruth; Crawford Mary A; Piatigorsky Joram
Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells.
Molecular and cellular biology 2007;27(1):182-94.
2007: Chandler Randy J; Sloan Jennifer; Fu Hong; Tsai Matthew; Stabler Sally; Allen Robert; Kaestner Klaus H; Kazazian Haig H; Venditti Charles P
Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle.
BMC medical genetics 2007;8():64.
2006: Mazzarelli Joan M; White Peter; Gorski Regina; Brestelli John; Pinney Deborah F; Arsenlis Athanasios; Katokhin Alexey; Belova Olga; Bogdanova Vera; Elisafenko Eugenij; Gubina Marina; Nizolenko Lilia; Perelman Polina; Puzakov Mikhail; Shilov Alexandre; Trifonoff Vladimir; Vorobjeva Nadezhda; Kolchanov Nikolay; Kaestner Klaus H; Stoeckert Christian J
Novel genes identified by manual annotation and microarray expression analysis in the pancreas.
Genomics 2006;88(6):752-61.
2006: Apte Udayan; Zeng Gang; Muller Peggy; Tan Xinping; Micsenyi Amanda; Cieply Benjamin; Dai Chunsun; Liu Youhua; Kaestner Klaus H; Monga Satdarshan P S
Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice.
Hepatology (Baltimore, Md.) 2006;44(4):992-1002.
2006: Vatamaniuk Marko Z; Gupta Rana K; Lantz Kristen A; Doliba Nicolai M; Matschinsky Franz M; Kaestner Klaus H
Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation.
Diabetes 2006;55(10):2730-6.
2006: Friedman J R; Kaestner K H
The Foxa family of transcription factors in development and metabolism.
Cellular and molecular life sciences : CMLS 2006;63(19-20):2317-28.
2006: Calmont Amélie; Wandzioch Ewa; Tremblay Kimberly D; Minowada George; Kaestner Klaus H; Martin Gail R; Zaret Kenneth S
An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells.
Developmental cell 2006;11(3):339-48.
2006: Doliba Nicolai M; Qin Wei; Vatamaniuk Marko Z; Buettger Carol W; Collins Heather W; Magnuson Mark A; Kaestner Klaus H; Wilson David F; Carr Richard D; Matschinsky Franz M
Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets.
American journal of physiology. Endocrinology and metabolism 2006;291(3):E525-35.
2006: Zelent Dorothy; Golson Maria L; Koeberlein Brigitte; Quintens Roel; van Lommel Leentje; Buettger Carol; Weik-Collins Heather; Taub Rebecca; Grimsby Joseph; Schuit Frans; Kaestner Klaus H; Matschinsky Franz M
A glucose sensor role for glucokinase in anterior pituitary cells.
Diabetes 2006;55(7):1923-9.
2006: Hara Manami; Dizon Restituto F; Glick Benjamin S; Lee Catherine S; Kaestner Klaus H; Piston David W; Bindokas Vytautas P
Imaging pancreatic beta-cells in the intact pancreas.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E1041-7.
2006: Garrison Wendy D; Battle Michele A; Yang Chuhu; Kaestner Klaus H; Sladek Frances M; Duncan Stephen A
Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon.
Gastroenterology 2006;130(4):1207-20.
2006: Kaestner Klaus H
Of cilia and cysts: modeling pancreatic polycystic disease.
Gastroenterology 2006;130(3):926-8.
2006: Burkhardt Brant R; Greene Scott R; White Peter; Wong Ryan K; Brestelli John E; Yang Jichun; Robert Claudia E; Brusko Todd M; Wasserfall Clive H; Wu Jianmei; Atkinson Mark A; Gao Zhiyong; Kaestner Klaus H; Wolf Bryan A
PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21).
Gene 2006;369():134-41.
2006: Lee Catherine S; De León Diva D; Kaestner Klaus H; Stoffers Doris A
Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3.
Diabetes 2006;55(2):269-72.
2006: De León Diva D; Farzad Cyrus; Crutchlow Michael F; Brestelli John; Tobias John; Kaestner Klaus H; Stoffers Doris A
Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment.
Physiological genomics 2006;24(2):133-43.
2005: Kaestner Klaus H
Collecting new targets in MODY.
Cell metabolism 2005;2(6):342-4.
2005: Besnard V; Wert S E; Kaestner K H; Whitsett J A
Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1.
American journal of physiology. Lung cellular and molecular physiology 2005;289(5):L750-9.
2005: Kaestner Klaus H
The making of the liver: developmental competence in foregut endoderm and induction of the hepatogenic program.
Cell cycle (Georgetown, Tex.) 2005;4(9):1146-8.
2005: Phuc Le Phillip; Friedman Joshua R; Schug Jonathan; Brestelli John E; Parker J Brandon; Bochkis Irina M; Kaestner Klaus H
Glucocorticoid receptor-dependent gene regulatory networks.
PLoS genetics 2005;1(2):e16.
2005: Zhang Liping; Rubins Nir E; Ahima Rexford S; Greenbaum Linda E; Kaestner Klaus H
Foxa2 integrates the transcriptional response of the hepatocyte to fasting.
Cell metabolism 2005;2(2):141-8.
2005: Rubins Nir E; Friedman Joshua R; Le Phillip P; Zhang Liping; Brestelli John; Kaestner Klaus H
Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2.
Molecular and cellular biology 2005;25(16):7069-77.
2005: Xiao Fang; Crissey Mary Ann S; Lynch John P; Kaestner Klaus H; Silberg Debra G; Suh Eunran
Intestinal metaplasia with a high salt diet induces epithelial proliferation and alters cell composition in the gastric mucosa of mice.
Cancer biology & therapy 2005;4(6):669-75.
2005: Lee Catherine S; Friedman Joshua R; Fulmer James T; Kaestner Klaus H
The initiation of liver development is dependent on Foxa transcription factors.
Nature 2005;435(7044):944-7.
2005: Katz Jonathan P; Perreault Nathalie; Goldstein Bree G; Actman Lori; McNally Sara R; Silberg Debra G; Furth Emma E; Kaestner Klaus H
Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach.
Gastroenterology 2005;128(4):935-45.
2005: Gupta Rana K; Vatamaniuk Marko Z; Lee Catherine S; Flaschen Reed C; Fulmer James T; Matschinsky Franz M; Duncan Stephen A; Kaestner Klaus H
The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion.
The Journal of clinical investigation 2005;115(4):1006-15.
2005: Wan Huajing; Dingle Sharon; Xu Yan; Besnard Valérie; Kaestner Klaus H; Ang Siew-Lan; Wert Susan; Stahlman Mildred T; Whitsett Jeffrey A
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.
The Journal of biological chemistry 2005;280(14):13809-16.
2005: Lantz Kristen A; Kaestner Klaus H
Winged-helix transcription factors and pancreatic development.
Clinical science (London, England : 1979) 2005;108(3):195-204.
2005: Lee Catherine S; Sund Newman J; Behr Rüdiger; Herrera Pedro L; Kaestner Klaus H
Foxa2 is required for the differentiation of pancreatic alpha-cells.
Developmental biology 2005;278(2):484-95.
2005: Perreault Nathalie; Sackett Sara D; Katz Jonathan P; Furth Emma E; Kaestner Klaus H
Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon.
Genes & development 2005;19(3):311-5.
2005: White Peter; Brestelli John E; Kaestner Klaus H; Greenbaum Linda E
Identification of transcriptional networks during liver regeneration.
The Journal of biological chemistry 2005;280(5):3715-22.
2004: Lee Catherine S; Kaestner Klaus H
Clinical endocrinology and metabolism. Development of gut endocrine cells.
Best practice & research. Clinical endocrinology & metabolism 2004;18(4):453-62.
2004: Krupczak-Hollis Katherine; Wang Xinhe; Kalinichenko Vladimir V; Gusarova Galina A; Wang I-Ching; Dennewitz Margaret B; Yoder Helena M; Kiyokawa Hiroaki; Kaestner Klaus H; Costa Robert H
The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis.
Developmental biology 2004;276(1):74-88.
2004: Gupta Rana K; Kaestner Klaus H
HNF-4alpha: from MODY to late-onset type 2 diabetes.
Trends in molecular medicine 2004;10(11):521-4.
2004: Wan Huajing; Xu Yan; Ikegami Machiko; Stahlman Mildred T; Kaestner Klaus H; Ang Siew-Lan; Whitsett Jeffrey A
Foxa2 is required for transition to air breathing at birth.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(40):14449-54.
2004: Behr Rüdiger; Brestelli John; Fulmer James T; Miyawaki Nobuyuki; Kleyman Thomas R; Kaestner Klaus H
Mild nephrogenic diabetes insipidus caused by Foxa1 deficiency.
The Journal of biological chemistry 2004;279(40):41936-41.
2004: Katz Jonathan P; Perreault Nathalie; Goldstein Bree G; Chao Hann-Hsiang; Ferraris Ronaldo P; Kaestner Klaus H
Foxl1 null mice have abnormal intestinal epithelia, postnatal growth retardation, and defective intestinal glucose uptake.
American journal of physiology. Gastrointestinal and liver physiology 2004;287(4):G856-64.
2004: Friedman Joshua R; Larris Brian; Le Phillip P; Peiris T Harshani; Arsenlis Athanasios; Schug Jonathan; Tobias John W; Kaestner Klaus H; Greenbaum Linda E
Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(35):12986-91.
2004: Lantz Kristen A; Vatamaniuk Marko Z; Brestelli John E; Friedman Joshua R; Matschinsky Franz M; Kaestner Klaus H
Foxa2 regulates multiple pathways of insulin secretion.
The Journal of clinical investigation 2004;114(4):512-20.
2004: Wan Huajing; Kaestner Klaus H; Ang Siew-Lan; Ikegami Machiko; Finkelman Fred D; Stahlman Mildred T; Fulkerson Patricia C; Rothenberg Marc E; Whitsett Jeffrey A
Foxa2 regulates alveolarization and goblet cell hyperplasia.
Development (Cambridge, England) 2004;131(4):953-64.
2003: Rangwala Shamina M; Rhoades Ben; Shapiro Jennifer S; Rich A Sophie; Kim Jason K; Shulman Gerald I; Kaestner Klaus H; Lazar Mitchell A
Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity.
Developmental cell 2003;5(4):657-63.
2003: Kaestner Klaus H; Lee Catherine S; Scearce L Marie; Brestelli John E; Arsenlis Athanasios; Le Phillip Phuc; Lantz Kristen A; Crabtree Jonathan; Pizarro Angel; Mazzarelli Joan; Pinney Deborah; Fischer Steve; Manduchi Elisabetta; Stoeckert Christian J; Gradwohl Gerard; Clifton Sandra W; Brown Juliana R; Inoue Hiroshi; Cras-Méneur Corentin; Permutt M Alan
Transcriptional program of the endocrine pancreas in mice and humans.
Diabetes 2003;52(7):1604-10.
2003: Parviz Fereshteh; Matullo Christine; Garrison Wendy D; Savatski Laura; Adamson John W; Ning Gang; Kaestner Klaus H; Rossi Jennifer M; Zaret Kenneth S; Duncan Stephen A
Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis.
Nature genetics 2003;34(3):292-6.
2002: Manduchi Elisabetta; Scearce L Marie; Brestelli John E; Grant Gregory R; Kaestner Klaus H; Stoeckert Christian J
Comparison of different labeling methods for two-channel high-density microarray experiments.
Physiological genomics 2002;10(3):169-79.
2002: Liu Yuanfang; Shen Wei; Brubaker Patricia L; Kaestner Klaus H; Drucker Daniel J
Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression.
The Biochemical journal 2002;366(Pt 2):633-41.
2002: Lee Catherine S; Sund Newman J; Vatamaniuk Marko Z; Matschinsky Franz M; Stoffers Doris A; Kaestner Klaus H
Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.
Diabetes 2002;51(8):2546-51.
2002: Scearce L Marie; Brestelli John E; McWeeney Shannon K; Lee Catherine S; Mazzarelli Joan; Pinney Deborah F; Pizarro Angel; Stoeckert Christian J; Clifton Sandra W; Permutt M Alan; Brown Juliana; Melton Douglas A; Kaestner Klaus H
Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research.
Diabetes 2002;51(7):1997-2004.
2002: Behr Rüdiger; Kaestner Klaus H
Developmental and cell type-specific expression of the zinc finger transcription factor Krüppel-like factor 4 (Klf4) in postnatal mouse testis.
Mechanisms of development 2002;115(1-2):167-9.
2002: Katz Jonathan P; Kaestner Klaus H
Cellular and molecular mechanisms of carcinogenesis.
Gastroenterology clinics of North America 2002;31(2):379-94.
2002: Lee Catherine S; Perreault Nathalie; Brestelli John E; Kaestner Klaus H
Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity.
Genes & development 2002;16(12):1488-97.
2002: Katz Jonathan P; Perreault Nathalie; Goldstein Bree G; Lee Catherine S; Labosky Patricia A; Yang Vincent W; Kaestner Klaus H
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.
Development (Cambridge, England) 2002;129(11):2619-28.
2002: Silberg Debra G; Sullivan Jessica; Kang Eugene; Swain Gary P; Moffett Jennifer; Sund Newman J; Sackett Sara D; Kaestner Klaus H
Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice.
Gastroenterology 2002;122(3):689-96.
2002: Hallonet Marc; Kaestner Klaus H; Martin-Parras Luis; Sasaki Hiroshi; Betz Ulrich A K; Ang Siew-Lan
Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: a study using HNF3beta/Foxa2 conditional mutants.
Developmental biology 2002;243(1):20-33.
2002: Parviz Fereshteh; Li Jixuan; Kaestner Klaus H; Duncan Stephen A
Generation of a conditionally null allele of hnf4alpha.
Genesis (New York, N.Y. : 2000) 2002;32(2):130-3.
2002: McDowell Susan A; Mallakin Ali; Bachurski Cindy J; Toney-Earley Kenya; Prows Daniel R; Bruno Theresa; Kaestner Klaus H; Witte David P; Melin-Aldana Hector; Degen Sandra J F; Leikauf George D; Waltz Susan E
The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury.
American journal of respiratory cell and molecular biology 2002;26(1):99-104.
2001: Perreault N; Katz J P; Sackett S D; Kaestner K H
Foxl1 controls the Wnt/beta-catenin pathway by modulating the expression of proteoglycans in the gut.
The Journal of biological chemistry 2001;276(46):43328-33.
2001: Shen W; Scearce L M; Brestelli J E; Sund N J; Kaestner K H
Foxa3 (hepatocyte nuclear factor 3gamma ) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast.
The Journal of biological chemistry 2001;276(46):42812-7.
2001: Waltz S E; Eaton L; Toney-Earley K; Hess K A; Peace B E; Ihlendorf J R; Wang M H; Kaestner K H; Degen S J
Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses.
The Journal of clinical investigation 2001;108(4):567-76.
2001: Silberg D G; Kaestner K H
Morphogenesis and maintenance of the gastric epithelium: a role for sonic hedgehog?
Gastroenterology 2001;121(2):485-7.
2001: Sund N J; Vatamaniuk M Z; Casey M; Ang S L; Magnuson M A; Stoffers D A; Matschinsky F M; Kaestner K H
Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia.
Genes & development 2001;15(13):1706-15.
2001: Cho H; Mu J; Kim J K; Thorvaldsen J L; Chu Q; Crenshaw E B; Kaestner K H; Bartolomei M S; Shulman G I; Birnbaum M J
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta).
Science (New York, N.Y.) 2001;292(5522):1728-31.
2001: Mukherjee D; Kaestner K H; Kovalovich K K; Greenbaum L E
Fas-induced apoptosis in mouse hepatocytes is dependent on C/EBPbeta.
Hepatology (Baltimore, Md.) 2001;33(5):1166-72.
2000: Kaestner K H
The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism.
Trends in endocrinology and metabolism: TEM 2000;11(7):281-5.
2000: Sund N J; Ang S L; Sackett S D; Shen W; Daigle N; Magnuson M A; Kaestner K H
Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte.
Molecular and cellular biology 2000;20(14):5175-83.
2000: Zhang W; Geiman D E; Shields J M; Dang D T; Mahatan C S; Kaestner K H; Biggs J R; Kraft A S; Yang V W
The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter.
The Journal of biological chemistry 2000;275(24):18391-8.
2000: Leatherman J L; Kaestner K H; Jongens T A
Identification of a mouse germ cell-less homologue with conserved activity in Drosophila.
Mechanisms of development 2000;92(2):145-53.
2000: Kaestner K H; Knochel W; Martinez D E
Unified nomenclature for the winged helix/forkhead transcription factors.
Genes & development 2000;14(2):142-6.
1999: Mahatan C S; Kaestner K H; Geiman D E; Yang V W
Characterization of the structure and regulation of the murine gene encoding gut-enriched Krüppel-like factor (Krüppel-like factor 4).
Nucleic acids research 1999;27(23):4562-9.
1999: Kaestner K H; Katz J; Liu Y; Drucker D J; Schütz G
Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo.
Genes & development 1999;13(4):495-504.
1998: Christoffels V M; Grange T; Kaestner K H; Cole T J; Darlington G J; Croniger C M; Lamers W H
Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene.
Molecular and cellular biology 1998;18(11):6305-15.
1998: Hiemisch H; Schütz G; Kaestner K H
The mouse Fkh1/Mf1 gene: cDNA sequence, chromosomal localization and expression in adult tissues.
Gene 1998;220(1-2):77-82.
1998: Labosky P A; Kaestner K H
The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development.
Mechanisms of development 1998;76(1-2):185-90.
1998: Kaestner K H; Hiemisch H; Schütz G
Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes.
Molecular and cellular biology 1998;18(7):4245-51.
1998: Reichardt H M; Kaestner K H; Tuckermann J; Kretz O; Wessely O; Bock R; Gass P; Schmid W; Herrlich P; Angel P; Schütz G
DNA binding of the glucocorticoid receptor is not essential for survival.
Cell 1998;93(4):531-41.
1998: Reichardt H M; Kaestner K H; Wessely O; Gass P; Schmid W; Schütz G
Analysis of glucocorticoid signalling by gene targeting.
The Journal of steroid biochemistry and molecular biology 1998;65(1-6):111-5.
1998: Hiemisch H; Monaghan A P; Schütz G; Kaestner K H
Expression of the mouse Fkh1/Mf1 and Mfh1 genes in late gestation embryos is restricted to mesoderm derivatives.
Mechanisms of development 1998;73(1):129-32.
1997: Ton-That H; Kaestner K H; Shields J M; Mahatanankoon C S; Yang V W
Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis.
FEBS letters 1997;419(2-3):239-43.
1997: Hiemisch H; Schütz G; Kaestner K H
Transcriptional regulation in endoderm development: characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesis.
The EMBO journal 1997;16(13):3995-4006.
1997: Kaestner K H; Silberg D G; Traber P G; Schütz G
The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation.
Genes & development 1997;11(12):1583-95.
1997: Mincheva A; Lichter P; Schütz G; Kaestner K H
Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4.
Genomics 1997;39(3):417-9.
1996: Kaestner K H; Bleckmann S C; Monaghan A P; Schlöndorff J; Mincheva A; Lichter P; Schütz G
Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development.
Development (Cambridge, England) 1996;122(6):1751-8.
1996: Ott T; Kaestner K H; Monaghan A P; Schütz G
The mouse homolog of the region specific homeotic gene spalt of Drosophila is expressed in the developing nervous system and in mesoderm-derived structures.
Mechanisms of development 1996;56(1-2):117-28.
1996: Kaestner K H; Schütz G; Monaghan A P
Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.
Mechanisms of development 1996;55(2):221-30.
1996: Blendy J A; Kaestner K H; Schmid W; Gass P; Schutz G
Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform.
The EMBO journal 1996;15(5):1098-106.
1996: Blendy J A; Kaestner K H; Weinbauer G F; Nieschlag E; Schütz G
Severe impairment of spermatogenesis in mice lacking the CREM gene.
Nature 1996;380(6570):162-5.
1995: Kaestner K H; Monaghan A P; Kern H; Ang S L; Weitz S; Lichter P; Schütz G
The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.
The Journal of biological chemistry 1995;270(50):30029-35.
1994: Kaestner K H; Montoliu L; Kern H; Thulke M; Schütz G
Universal beta-galactosidase cloning vectors for promoter analysis and gene targeting.
Gene 1994;148(1):67-70.
1994: Kaestner K H; Hiemisch H; Luckow B; Schütz G
The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution.
Genomics 1994;20(3):377-85.
1993: Monaghan A P; Kaestner K H; Grau E; Schütz G
Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm.
Development (Cambridge, England) 1993;119(3):567-78.
1993: Flores-Riveros J R; Kaestner K H; Thompson K S; Lane M D
Cyclic AMP-induced transcriptional repression of the insulin-responsive glucose transporter (GLUT4) gene: identification of a promoter region required for down-regulation of transcription.
Biochemical and biophysical research communications 1993;194(3):1148-54.
1993: Kaestner K H; Lee K H; Schlöndorff J; Hiemisch H; Monaghan A P; Schütz G
Six members of the mouse forkhead gene family are developmentally regulated.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7628-31.
1993: Ezaki O; Flores-Riveros J R; Kaestner K H; Gearhart J; Lane M D
Regulated expression of an insulin-responsive glucose transporter (GLUT4) minigene in 3T3-L1 adipocytes and transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3348-52.
1991: Narayanan V; Kaestner K H; Tennekoon G I
Structure of the mouse myelin P2 protein gene.
Journal of neurochemistry 1991;57(1):75-80.
1991: Christy R J; Kaestner K H; Geiman D E; Lane M D
CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2593-7.
1991: Kaestner K H; Flores-Riveros J R; McLenithan J C; Janicot M; Lane M D
Transcriptional repression of the mouse insulin-responsive glucose transporter (GLUT4) gene by cAMP.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1933-7.
1990: Lane M D; Flores-Riveros J R; Hresko R C; Kaestner K H; Liao K; Janicot M; Hoffman R D; McLenithan J C; Kastelic T; Christy R J
Insulin-receptor tyrosine kinase and glucose transport.
Diabetes care 1990;13(6):565-75.
1990: Kaestner K H; Christy R J; Lane M D
Mouse insulin-responsive glucose transporter gene: characterization of the gene and trans-activation by the CCAAT/enhancer binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(1):251-5.
1989: Kaestner K H; Ntambi J M; Kelly T J; Lane M D
Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase.
The Journal of biological chemistry 1989;264(25):14755-61.
1989: Kaestner K H; Christy R J; McLenithan J C; Braiterman L T; Cornelius P; Pekala P H; Lane M D
Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3150-4.
1988: Ntambi J M; Buhrow S A; Kaestner K H; Christy R J; Sibley E; Kelly T J; Lane M D
Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase.
The Journal of biological chemistry 1988;263(33):17291-300.
1988: Kaestner K H; Randall S K; Sze H
N,N'-dicyclohexylcarbodiimide-binding proteolipid of the vacuolar H+-ATPase from oat roots.
The Journal of biological chemistry 1988;263(3):1282-7.

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