Robert Margolskee

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Yoshida Ryusuke; Miyauchi Aya; Yasuo Toshiaki; Jyotaki Masafumi; Murata Yoshihiro; Yasumatsu Keiko; Shigemura Noriatsu; Yanagawa Yuchio; Obata Kunihiko; Ueno Hiroshi; Margolskee Robert F; Ninomiya Yuzo
Discrimination of taste qualities among mouse fungiform taste bud cells.
Kokrashvili Zaza; Mosinger Bedrich; Margolskee Robert F
Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones.
Kokrashvili Zaza; Rodriguez Deniliz; Yevshayeva Valeriya; Zhou Hang; Margolskee Robert F; Mosinger Bedrich
Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5.

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2009: Yoshida Ryusuke; Miyauchi Aya; Yasuo Toshiaki; Jyotaki Masafumi; Murata Yoshihiro; Yasumatsu Keiko; Shigemura Noriatsu; Yanagawa Yuchio; Obata Kunihiko; Ueno Hiroshi; Margolskee Robert F; Ninomiya Yuzo
Discrimination of taste qualities among mouse fungiform taste bud cells.
The Journal of physiology 2009;587(Pt 18):4425-39.
2009: Kokrashvili Zaza; Mosinger Bedrich; Margolskee Robert F
Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones.
The American journal of clinical nutrition 2009;90(3):822S-825S.
2009: Kokrashvili Zaza; Rodriguez Deniliz; Yevshayeva Valeriya; Zhou Hang; Margolskee Robert F; Mosinger Bedrich
Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5.
Gastroenterology 2009;137(2):598-606, 606.e1-2.
2009: Kokrashvili Zaza; Mosinger Bedrich; Margolskee Robert F
T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1.
Annals of the New York Academy of Sciences 2009;1170():91-4.
2009: Ohkuri Tadahiro; Yasumatsu Keiko; Horio Nao; Jyotaki Masafumi; Margolskee Robert F; Ninomiya Yuzo
Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;296(4):R960-71.
2009: Zukerman Steven; Glendinning John I; Margolskee Robert F; Sclafani Anthony
T1R3 taste receptor is critical for sucrose but not Polycose taste.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;296(4):R866-76.
2009: Wang Hong; Iguchi Naoko; Rong Qi; Zhou Minliang; Ogunkorode Martina; Inoue Masashi; Pribitkin Edmund A; Bachmanov Alexander A; Margolskee Robert F; Pfeifer Karl; Huang Liquan
Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences.
The Journal of comparative neurology 2009;512(3):384-98.
2008: Clapp Tod R; Trubey Kristina R; Vandenbeuch Aurelie; Stone Leslie M; Margolskee Robert F; Chaudhari Nirupa; Kinnamon Sue C
Tonic activity of Galpha-gustducin regulates taste cell responsivity.
FEBS letters 2008;582(27):3783-7.
2008: Tordoff Michael G; Shao Hongguang; Alarcón Laura K; Margolskee Robert F; Mosinger Bedrich; Bachmanov Alexander A; Reed Danielle R; McCaughey Stuart
Involvement of T1R3 in calcium-magnesium taste.
Physiological genomics 2008;34(3):338-48.
2008: Talavera Karel; Yasumatsu Keiko; Yoshida Ryusuke; Margolskee Robert F; Voets Thomas; Ninomiya Yuzo; Nilius Bernd
The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1343-55.
2008: Egan Josephine M; Margolskee Robert F
Taste cells of the gut and gastrointestinal chemosensation.
Molecular interventions 2008;8(2):78-81.
2008: Lin Weihong; Ogura Tatsuya; Margolskee Robert F; Finger Thomas E; Restrepo Diego
TRPM5-expressing solitary chemosensory cells respond to odorous irritants.
Journal of neurophysiology 2008;99(3):1451-60.
2008: Blednov Y A; Walker D; Martinez M; Levine M; Damak S; Margolskee R F
Perception of sweet taste is important for voluntary alcohol consumption in mice.
Genes, brain, and behavior 2008;7(1):1-13.
2008: Damak Sami; Mosinger Bedrich; Margolskee Robert F
Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice.
BMC neuroscience 2008;9():96.
2007: Dyer J; Daly K; Salmon K S H; Arora D K; Kokrashvili Z; Margolskee R F; Shirazi-Beechey S P
Intestinal glucose sensing and regulation of intestinal glucose absorption.
Biochemical Society transactions 2007;35(Pt 5):1191-4.
2007: Ogura Tatsuya; Margolskee Robert F; Tallini Yvonne N; Shui Bo; Kotlikoff Michael I; Lin Weihong
Immuno-localization of vesicular acetylcholine transporter in mouse taste cells and adjacent nerve fibers: indication of acetylcholine release.
Cell and tissue research 2007;330(1):17-28.
2007: Sclafani Anthony; Zukerman Steven; Glendinning John I; Margolskee Robert F
Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(4):R1504-13.
2007: Margolskee Robert F; Dyer Jane; Kokrashvili Zaza; Salmon Kieron S H; Ilegems Erwin; Daly Kristian; Maillet Emeline L; Ninomiya Yuzo; Mosinger Bedrich; Shirazi-Beechey Soraya P
T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):15075-80.
2007: Jang Hyeung-Jin; Kokrashvili Zaza; Theodorakis Michael J; Carlson Olga D; Kim Byung-Joon; Zhou Jie; Kim Hyeon Ho; Xu Xiangru; Chan Sic L; Juhaszova Magdalena; Bernier Michel; Mosinger Bedrich; Margolskee Robert F; Egan Josephine M
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):15069-74.
2007: Zhang Zheng; Zhao Zhen; Margolskee Robert; Liman Emily
The transduction channel TRPM5 is gated by intracellular calcium in taste cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(21):5777-86.
2007: Iwatsuki Ken; Liu Hong-Xiang; Grónder Albert; Singer Meredith A; Lane Timothy F; Grosschedl Rudolf; Mistretta Charlotte M; Margolskee Robert F
Wnt signaling interacts with Shh to regulate taste papilla development.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2253-8.
2007: Lin Weihong; Margolskee Robert; Donnert Gerald; Hell Stefan W; Restrepo Diego
Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2471-6.
2007: Romanov Roman A; Rogachevskaja Olga A; Bystrova Marina F; Jiang Peihua; Margolskee Robert F; Kolesnikov Stanislav S
Afferent neurotransmission mediated by hemichannels in mammalian taste cells.
The EMBO journal 2007;26(3):657-67.
2006: Danilova Vicktoria; Damak Sami; Margolskee Robert F; Hellekant Göran
Taste responses to sweet stimuli in alpha-gustducin knockout and wild-type mice.
Chemical senses 2006;31(6):573-80.
2006: Delay E R; Hernandez N P; Bromley K; Margolskee R F
Sucrose and monosodium glutamate taste thresholds and discrimination ability of T1R3 knockout mice.
Chemical senses 2006;31(4):351-7.
2006: Li Zairong; Benard Outhiriaradjou; Margolskee Robert F
Ggamma13 interacts with PDZ domain-containing proteins.
The Journal of biological chemistry 2006;281(16):11066-73.
2006: Damak Sami; Rong Minqing; Yasumatsu Keiko; Kokrashvili Zaza; Pérez Cristian A; Shigemura Noriatsu; Yoshida Ryusuke; Mosinger Bedrich; Glendinning John I; Ninomiya Yuzo; Margolskee Robert F
Trpm5 null mice respond to bitter, sweet, and umami compounds.
Chemical senses 2006;31(3):253-64.
2006: Maruyama Yutaka; Pereira Elizabeth; Margolskee Robert F; Chaudhari Nirupa; Roper Stephen D
Umami responses in mouse taste cells indicate more than one receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(8):2227-34.
2006: Cui Meng; Jiang Peihua; Maillet Emeline; Max Marianna; Margolskee Robert F; Osman Roman
The heterodimeric sweet taste receptor has multiple potential ligand binding sites.
Current pharmaceutical design 2006;12(35):4591-600.
2006: Clapp Tod R; Medler Kathryn F; Damak Sami; Margolskee Robert F; Kinnamon Sue C
Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25.
BMC biology 2006;4():7.
2005: Talavera Karel; Yasumatsu Keiko; Voets Thomas; Droogmans Guy; Shigemura Noriatsu; Ninomiya Yuzo; Margolskee Robert F; Nilius Bernd
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste.
Nature 2005;438(7070):1022-5.
2005: Jiang Peihua; Cui Meng; Zhao Baohua; Snyder Lenore A; Benard Lumie M J; Osman Roman; Max Marianna; Margolskee Robert F
Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3.
The Journal of biological chemistry 2005;280(40):34296-305.
2005: Margolskee Robert F
Teaching resources. Sensory systems: taste perception.
Science's STKE : signal transduction knowledge environment 2005;2005(290):tr20.
2005: Glendinning John I; Bloom Lauren D; Onishi Maika; Zheng Kun Hao; Damak Sami; Margolskee Robert F; Spector Alan C
Contribution of alpha-gustducin to taste-guided licking responses of mice.
Chemical senses 2005;30(4):299-316.
2005: Jiang Peihua; Cui Meng; Zhao Baohua; Liu Zhan; Snyder Lenore A; Benard Lumie M J; Osman Roman; Margolskee Robert F; Max Marianna
Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.
The Journal of biological chemistry 2005;280(15):15238-46.
2005: Rong Minqing; He Wei; Yasumatsu Keiko; Kokrashvili Zaza; Perez Cristian A; Mosinger Bedrich; Ninomiya Yuzo; Margolskee Robert F; Damak Sami
Signal transduction of umami taste: insights from knockout mice.
Chemical senses 2005;30 Suppl 1():i33-4.
2005: Jiang P; Cui M; Ji Q; Snyder L; Liu Z; Benard L; Margolskee R F; Osman R; Max M
Molecular mechanisms of sweet receptor function.
Chemical senses 2005;30 Suppl 1():i17-8.
2004: Jiang Peihua; Ji Qingzhou; Liu Zhan; Snyder Lenore A; Benard Lumie M J; Margolskee Robert F; Max Marianna
The cysteine-rich region of T1R3 determines responses to intensely sweet proteins.
The Journal of biological chemistry 2004;279(43):45068-75.
2004: He Wei; Yasumatsu Keiko; Varadarajan Vijaya; Yamada Ayako; Lem Janis; Ninomiya Yuzo; Margolskee Robert F; Damak Sami
Umami taste responses are mediated by alpha-transducin and alpha-gustducin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(35):7674-80.
2003: Caicedo Alejandro; Pereira Elizabeth; Margolskee Robert F; Roper Stephen D
Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(30):9947-52.
2003: Ruiz Collin J; Wray Kinsey; Delay Eugene; Margolskee Robert F; Kinnamon Sue C
Behavioral evidence for a role of alpha-gustducin in glutamate taste.
Chemical senses 2003;28(7):573-9.
2003: Damak Sami; Rong Minqing; Yasumatsu Keiko; Kokrashvili Zaza; Varadarajan Vijaya; Zou Shiying; Jiang Peihua; Ninomiya Yuzo; Margolskee Robert F
Detection of sweet and umami taste in the absence of taste receptor T1r3.
Science (New York, N.Y.) 2003;301(5634):850-3.
2003: Pérez Cristian A; Margolskee Robert F; Kinnamon Sue C; Ogura Tatsuya
Making sense with TRP channels: store-operated calcium entry and the ion channel Trpm5 in taste receptor cells.
Cell calcium 2003;33(5-6):541-9.
2003: Medler Kathryn F; Margolskee Robert F; Kinnamon Sue C
Electrophysiological characterization of voltage-gated currents in defined taste cell types of mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(7):2608-17.
2003: Huang Liquan; Max Marianna; Margolskee Robert F; Su Hui; Masland Richard H; Euler Thomas
G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells.
The Journal of comparative neurology 2003;455(1):1-10.
2002: Pérez Cristian A; Huang Liquan; Rong Minqing; Kozak J Ashot; Preuss Axel K; Zhang Hailin; Max Marianna; Margolskee Robert F
A transient receptor potential channel expressed in taste receptor cells.
Nature neuroscience 2002;5(11):1169-76.
2002: He Wei; Danilova Vicktoria; Zou Shiying; Hellekant Göran; Max Marianna; Margolskee Robert F; Damak Sami
Partial rescue of taste responses of alpha-gustducin null mice by transgenic expression of alpha-transducin.
Chemical senses 2002;27(8):719-27.
2002: Ogura Tatsuya; Margolskee Robert F; Kinnamon Sue C
Taste receptor cell responses to the bitter stimulus denatonium involve Ca2+ influx via store-operated channels.
Journal of neurophysiology 2002;87(6):3152-5.
2002: Margolskee Robert F
Molecular mechanisms of bitter and sweet taste transduction.
The Journal of biological chemistry 2002;277(1):1-4.
2002: Moriyama Kosei; Bakre Manjiri M; Ahmed Farooq; Spickofsky Nancy; Max Marianna; Margolskee Robert F
Assaying G protein-phosphodiesterase interactions in sensory systems.
Methods in enzymology 2002;345():37-48.
2001: Ruiz-Avila L; Wong G T; Damak S; Margolskee R F
Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in alpha -gustducin.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8868-73.
2001: Max M; Shanker Y G; Huang L; Rong M; Liu Z; Campagne F; Weinstein H; Damak S; Margolskee R F
Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac.
Nature genetics 2001;28(1):58-63.
2001: Smith D V; Margolskee R F
Making sense of taste.
Scientific American 2001;284(3):32-9.
2001: Clapp T R; Stone L M; Margolskee R F; Kinnamon S C
Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction.
BMC neuroscience 2001;2():6.
2000: Calvert P D; Krasnoperova N V; Lyubarsky A L; Isayama T; Nicoló M; Kosaras B; Wong G; Gannon K S; Margolskee R F; Sidman R L; Pugh E N; Makino C L; Lem J
Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13913-8.
2000: Yang R; Tabata S; Crowley H H; Margolskee R F; Kinnamon J C
Ultrastructural localization of gustducin immunoreactivity in microvilli of type II taste cells in the rat.
The Journal of comparative neurology 2000;425(1):139-51.
2000: Gilbertson T A; Damak S; Margolskee R F
The molecular physiology of taste transduction.
Current opinion in neurobiology 2000;10(4):519-27.
2000: Ruiz-Avila L; Ming D; Margolskee R F
An In vitro assay useful to determine the potency of several bitter compounds.
Chemical senses 2000;25(4):361-8.
1999: Huang L; Shanker Y G; Dubauskaite J; Zheng J Z; Yan W; Rosenzweig S; Spielman A I; Max M; Margolskee R F
Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.
Nature neuroscience 1999;2(12):1055-62.
1999: Ming D; Ninomiya Y; Margolskee R F
Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9903-8.
1999: Wong G T; Ruiz-Avila L; Margolskee R F
Directing gene expression to gustducin-positive taste receptor cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(14):5802-9.
1998: Max M; Surya A; Takahashi J S; Margolskee R F; Knox B E
Light-dependent activation of rod transducin by pineal opsin.
The Journal of biological chemistry 1998;273(41):26820-6.
1998: Ming D; Ruiz-Avila L; Margolskee R F
Characterization and solubilization of bitter-responsive receptors that couple to gustducin.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8933-8.
1998: Kolesnikov S S; Margolskee R F
Extracellular K+ activates a K(+)- and H(+)-permeable conductance in frog taste receptor cells.
The Journal of physiology 1998;507 ( Pt 2)():415-32.
1996: McKinnon P J; Kapsetaki M; Margolskee R F
The exon structure of the mouse Sc1 gene is very similar to the mouse Sparc gene.
Genome research 1996;6(11):1077-83.
1996: Kinnamon S C; Margolskee R F
Mechanisms of taste transduction.
Current opinion in neurobiology 1996;6(4):506-13.
1996: Wong G T; Gannon K S; Margolskee R F
Transduction of bitter and sweet taste by gustducin.
Nature 1996;381(6585):796-800.
1996: McKinnon P J; Margolskee R F
SC1: a marker for astrocytes in the adult rodent brain is upregulated during reactive astrocytosis.
Brain research 1996;709(1):27-36.
1996: Wong G T; Ruiz-Avila L; Ming D; Gannon K S; Margolskee R F
Biochemical and transgenic analysis of gustducin's role in bitter and sweet transduction.
Cold Spring Harbor symposia on quantitative biology 1996;61():173-84.
1995: Ruiz-Avila L; McLaughlin S K; Wildman D; McKinnon P J; Robichon A; Spickofsky N; Margolskee R F
Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells.
Nature 1995;376(6535):80-5.
1995: Kolesnikov S S; Margolskee R F
A cyclic-nucleotide-suppressible conductance activated by transducin in taste cells.
Nature 1995;376(6535):85-8.
1995: Max M; McKinnon P J; Seidenman K J; Barrett R K; Applebury M L; Takahashi J S; Margolskee R F
Pineal opsin: a nonvisual opsin expressed in chick pineal.
Science (New York, N.Y.) 1995;267(5203):1502-6.
1994: McLaughlin S K; McKinnon P J; Spickofsky N; Danho W; Margolskee R F
Molecular cloning of G proteins and phosphodiesterases from rat taste cells.
Physiology & behavior 1994;56(6):1157-64.
1994: Spickofsky N; Robichon A; Danho W; Fry D; Greeley D; Graves B; Madison V; Margolskee R F
Biochemical analysis of the transducin-phosphodiesterase interaction.
Nature structural biology 1994;1(11):771-81.
1994: Takami S; Getchell T V; McLaughlin S K; Margolskee R F; Getchell M L
Human taste cells express the G protein alpha-gustducin and neuron-specific enolase.
Brain research. Molecular brain research 1994;22(1-4):193-203.
1993: Margolskee R F; McHendry-Rinde B; Horn R
Panning transfected cells for electrophysiological studies.
BioTechniques 1993;15(5):906-11.
1993: Margolskee R F
The molecular biology of taste transduction.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(10):645-50.
1993: McLaughlin S K; Margolskee R F
33P is preferable to 35S for labeling probes used in in situ hybridization.
BioTechniques 1993;15(3):506-11.
1993: Margolskee R F
The biochemistry and molecular biology of taste transduction.
Current opinion in neurobiology 1993;3(4):526-31.
1993: McLaughlin S K; McKinnon P J; Robichon A; Spickofsky N; Margolskee R F
Gustducin and transducin: a tale of two G proteins.
Ciba Foundation symposium 1993;179():186-96; discussion 196-200.
1992: McLaughlin S K; McKinnon P J; Margolskee R F
Gustducin is a taste-cell-specific G protein closely related to the transducins.
Nature 1992;357(6379):563-9.
1992: Garret M; McHendry-Rinde B; Spickofsky N; Margolskee R F
Isolation of a clone which induces expression of the gene encoding the human tumor necrosis factor receptor.
Gene 1992;111(2):215-22.
1991: Spickofsky N; Margolskee R F
A highly efficient directional cDNA cloning method utilizing an asymmetrically tailed linker-primer plasmid.
Nucleic acids research 1991;19(25):7105-11.
1990: Canfield V; Emanuel J R; Spickofsky N; Levenson R; Margolskee R F
Ouabain-resistant mutants of the rat Na,K-ATPase alpha 2 isoform identified by using an episomal expression vector.
Molecular and cellular biology 1990;10(4):1367-72.
1984: Margolskee R F; Nathans D
Simian virus 40 mutant T antigens with relaxed specificity for the nucleotide sequence at the viral DNA origin of replication.
Journal of virology 1984;49(2):386-93.
1979: Shortle D R; Margolskee R F; Nathans D
Mutational analysis of the simian virus 40 replicon: pseudorevertants of mutants with a defective replication origin.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(12):6128-31.

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Robert Margolskee

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