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Meinrad Busslinger

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Chemicals & Drugs

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Anatomy

B-Lymphocytes

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Frederick Masson; Martina Minnich; Adele M Mount; Stephen L Nutt; Moshe Olshansky; Terence P Speed; Ivan Bilic; Meinrad Busslinger; Axel Kallies; Gabrielle T Belz
Id2-Mediated Inhibition of E2A Represses Memory CD8+ T Cell Differentiation.
Nobuhisa Ohtsuka; Sylvia Badurek; Francine M Benes; Meinrad Busslinger; Liliana Minichiello; Uwe Rudolph
GABAergic neurons regulate lateral ventricular development via transcription factor Pax5.
Fatemehsadat Esteghamat; Nynke Gillemans; Frank Grosveld; Ursula Klingmüller; Ivan Bilic; Thamar Bryn van Dijk; Meinrad Busslinger; Ileana Cantù; Emile van den Akker; Teus van Gent; Kirsten van Lom; Marieke von Lindern; Sjaak Philipsen
Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.

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2013: Frederick Masson; Martina Minnich; Adele M Mount; Stephen L Nutt; Moshe Olshansky; Terence P Speed; Ivan Bilic; Meinrad Busslinger; Axel Kallies; Gabrielle T Belz
Id2-Mediated Inhibition of E2A Represses Memory CD8+ T Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(9):4585-94.
2013: Nobuhisa Ohtsuka; Sylvia Badurek; Francine M Benes; Meinrad Busslinger; Liliana Minichiello; Uwe Rudolph
GABAergic neurons regulate lateral ventricular development via transcription factor Pax5.
Genesis (New York, N.Y. : 2000) 2013;51(4):234-45.
2013: Fatemehsadat Esteghamat; Nynke Gillemans; Frank Grosveld; Ursula Klingmüller; Ivan Bilic; Thamar Bryn van Dijk; Meinrad Busslinger; Ileana Cantù; Emile van den Akker; Teus van Gent; Kirsten van Lom; Marieke von Lindern; Sjaak Philipsen
Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.
Blood 2013;121(13):2553-62.
2013: Soo Seok Hwang; Sung Woong Jang; Joomyeong Kim; Min Kyung Kim; Young Uk Kim; Byung Hee Koh; Sumin Lee; Wonyong Lee; Abdallah Souabni; Meinrad Busslinger; Gap Ryol Lee
Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(1):276-81.
2012: Thomas Hoyler; Christoph S N Klose; Dietmar Pfeifer; Emma L Rawlins; Abdallah Souabni; Adriana Turqueti-Neves; David Voehringer; Meinrad Busslinger; Andreas Diefenbach
The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells.
Immunity 2012;37(4):634-48.
2012: Roger Revilla-i-Domingo; Leonie Smeenk; Andreas Sommer; Hiromi Tagoh; Ido M Tamir; Johanna Trupke; Bojan Vilagos; Ivan Bilic; Anja Ebert; Markus Jaritz; Meinrad Busslinger
The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis.
The EMBO journal 2012;31(14):3130-46.
2012: Agnieszka Demczuk; Michel G Gauthier; Settapong Kosiyatrakul; John Bechhoefer; Meinrad Busslinger; Carl L Schildkraut; Ingrid Veras; Paolo Norio
Regulation of DNA replication within the immunoglobulin heavy-chain locus during B cell commitment.
PLoS biology 2012;10(7):e1001360.
2012: Bojan Vilagos; Barbara Werner; Elin Axelsson; Ivan Bilic; Mareike Hoffmann; Markus Jaritz; Jasna Medvedovic; Martina Minnich; Abdallah Souabni; Qiong Sun; Meinrad Busslinger
Essential role of EBF1 in the generation and function of distinct mature B cell types.
The Journal of experimental medicine 2012;209(4):775-92.
2011: Chunguang Guo; Erica Hansen; Suvi Jain; Cornelis Murre; Darienne Myers; Harin Patel; Nicholas Richards; Mark S Schlissel; Christian Vettermann; Hye Suk Yoon; Jamie G Bates; Claudia Bossen; Meinrad Busslinger; Hwei-Ling Cheng; Orion Despo; Anja Ebert; Andrew Franklin; Michael Gallagher; Cosmas C Giallourakis; Frederick W Alt
CTCF-binding elements mediate control of V(D)J recombination.
Nature 2011;477(7365):424-30.
2011: Shane McManus; Jasna Medvedovic; Giorgia Salvagiotto; Qiong Sun; Hiromi Tagoh; Ido Tamir; Anja Ebert; Markus Jaritz; Meinrad Busslinger
The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells.
The EMBO journal 2011;30(12):2388-404.
2011: Erika Cretney; Annie Xin; Wei Shi; Martina Minnich; Frederick Masson; Maria Miasari; Gabrielle T Belz; Gordon K Smyth; Meinrad Busslinger; Stephen L Nutt; Axel Kallies
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells.
Nature immunology 2011;12(4):304-11.
2011: Idoia Gimferrer; Taishan Hu; Amie Simmons; Chi Wang; Abdallah Souabni; Meinrad Busslinger; Timothy P Bender; Gabriela Hernandez-Hoyos; José Alberola-Ila
Regulation of GATA-3 expression during CD4 lineage differentiation.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):3892-8.
2011: Anja Ebert; Shane McManus; Hiromi Tagoh; Jasna Medvedovic; Giorgia Salvagiotto; Maria Novatchkova; Ido Tamir; Andreas Sommer; Markus Jaritz; Meinrad Busslinger
The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells.
Immunity 2011;34(2):175-87.
2011: Jasna Medvedovic; Hiromi Tagoh; Anja Ebert; Meinrad Busslinger
Pax5: a master regulator of B cell development and leukemogenesis.
Advances in immunology 2011;111():179-206.
2010: Ingela Vikstrom; Sebastian Carotta; Katja Lüthje; Victor Peperzak; Philipp J Jost; Stefan Glaser; Meinrad Busslinger; Philippe Bouillet; Andreas Strasser; Stephen L Nutt; David M Tarlinton
Mcl-1 is essential for germinal center formation and B cell memory.
Science (New York, N.Y.) 2010;330(6007):1095-9.
2010: Ian J Majewski; Matthew E Ritchie; Belinda Phipson; Jason Corbin; Miha Pakusch; Anja Ebert; Meinrad Busslinger; Haruhiko Koseki; Yifang Hu; Gordon K Smyth; Warren S Alexander; Douglas J Hilton; Marnie E Blewitt
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.
Blood 2010;116(5):731-9.
2010: Burles A Johnson; David J Kahler; Babak Baban; Phillip R Chandler; Baolin Kang; Michiko Shimoda; Pandelakis Koni; Jeanene Pihkala; Bojan Vilagos; Meinrad Busslinger; David H Munn; Andrew L Mellor
B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(23):10644-8.
2010: Stephen Malin; Shane McManus; Meinrad Busslinger
STAT5 in B cell development and leukemia.
Current opinion in immunology 2010;22(2):168-76.
2010: Stephen Malin; Shane McManus; César Cobaleda; Maria Novatchkova; Alessio Delogu; Philippe Bouillet; Andreas Strasser; Meinrad Busslinger
Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.
Nature immunology 2010;11(2):171-9.
2010: Maxime Bouchard; Dominique de Caprona; Meinrad Busslinger; Pinxian Xu; Bernd Fritzsch
Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation.
BMC developmental biology 2010;10():89.
2009: Susannah L Hewitt; Bu Yin; Yanhong Ji; julie chaumeil; Katarzyna Marszalek; Jeannette Tenthorey; Giorgia Salvagiotto; Natalie Steinel; Laura B Ramsey; Jacques Ghysdael; Michael A Farrar; Barry P Sleckman; David G Schatz; Meinrad Busslinger; Craig H Bassing; Jane A Skok
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.
Nature immunology 2009;10(6):655-64.
2009: Thorsten Decker; Marina Pasca di Magliano; Shane McManus; Qiong Sun; Constanze Bonifer; Hiromi Tagoh; Meinrad Busslinger
Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis.
Immunity 2009;30(4):508-20.
2008: Gunnar Schotta; Roopsha Sengupta; Stefan Kubicek; Stephen Malin; Monika Kauer; Elsa Callén; Arkady Celeste; Michaela Pagani; Susanne Opravil; Inti De La Rosa Velázquez; Alexsandra Espejo; Mark T Bedford; André Nussenzweig; Meinrad Busslinger; Thomas Jenuwein
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.
Genes & development 2008;22(15):2048-61.
2008: Feng Guo; Simone Tänzer; Meinrad Busslinger; Falk Weih
Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis.
Blood 2008;112(3):551-9.
2008: Kyongrim Kwon; Caroline Hutter; Qiong Sun; Ivan Bilic; César Cobaleda; Stephen Malin; Meinrad Busslinger
Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development.
Immunity 2008;28(6):751-62.
2008: Thomas Graf; Meinrad Busslinger
B young again.
Immunity 2008;28(5):606-8.
2008: César Cobaleda; Meinrad Busslinger
Developmental plasticity of lymphocytes.
Current opinion in immunology 2008;20(2):139-48.
2007: César Cobaleda; Wolfram Jochum; Meinrad Busslinger
Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors.
Nature 2007;449(7161):473-7.
2007: Javier Martinez; Meinrad Busslinger
Life beyond cleavage: the case of Ago2 and hematopoiesis.
Genes & development 2007;21(16):1983-8.
2007: Alexandra Schebesta; Shane McManus; Giorgia Salvagiotto; Alessio Delogu; Georg A Busslinger; Meinrad Busslinger
Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.
Immunity 2007;27(1):49-63.
2007: Derk Amsen; Andrey Antov; Dragana Jankovic; Alan Sher; Freddy Radtke; Abdallah Souabni; Meinrad Busslinger; Brent McCright; Thomas Gridley; Richard A Flavell
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.
Immunity 2007;27(1):89-99.
2007: Martin Fuxa; Meinrad Busslinger
Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):8222-8.
2007: Stephen J Bruce; Robert W Rea; Anita L Steptoe; Meinrad Busslinger; John F Bertram; Andrew C Perkins
In vitro differentiation of murine embryonic stem cells toward a renal lineage.
Differentiation; research in biological diversity 2007;75(5):337-49.
2007: César Cobaleda; Alexandra Schebesta; Alessio Delogu; Meinrad Busslinger
Pax5: the guardian of B cell identity and function.
Nature immunology 2007;8(5):463-70.
2007: Jane A Skok; Ramiro Gisler; Maria Novatchkova; Deborah Farmer; Wouter de Laat; Meinrad Busslinger
Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes.
Nature immunology 2007;8(4):378-87.
2007: Martin Fuxa; Meinrad Busslinger
Reporter gene insertions reveal a strictly B lymphoid-specific expression pattern of Pax5 in support of its B cell identity function.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3031-7.
2007: Stephanie Roessler; Ildiko Györy; Sascha Imhof; Mikhail Spivakov; Ruth R Williams; Meinrad Busslinger; Amanda G Fisher; Rudolf Grosschedl
Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5.
Molecular and cellular biology 2007;27(2):579-94.
2007: Abdallah Souabni; Wolfram Jochum; Meinrad Busslinger
Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus.
Blood 2007;109(1):281-9.
2006: Fabio Savarese; Katja Flahndorfer; Rudolf Jaenisch; Meinrad Busslinger; Anton Wutz
Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation.
Molecular and cellular biology 2006;26(19):7167-77.
2006: Gunnar Weisheit; Michael Gliem; Elmar Endl; Peter L Pfeffer; Meinrad Busslinger; Karl Schilling
Postnatal development of the murine cerebellar cortex: formation and early dispersal of basket, stellate and Golgi neurons.
The European journal of neuroscience 2006;24(2):466-78.
2006: Hiromi Tagoh; Richard Ingram; Nicola Wilson; Giorgia Salvagiotto; Alan J Warren; Deborah Clarke; Meinrad Busslinger; Constanze Bonifer
The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction.
The EMBO journal 2006;25(5):1070-80.
2006: Alessio Delogu; Alexandra Schebesta; Qiong Sun; Katharina Aschenbrenner; Thomas Perlot; Meinrad Busslinger
Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.
Immunity 2006;24(3):269-81.
2006: David Grote; Abdallah Souabni; Meinrad Busslinger; Maxime Bouchard
Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney.
Development (Cambridge, England) 2006;133(1):53-61.
2005: Maxime Bouchard; David Grote; Sarah E Craven; Qiong Sun; Peter Steinlein; Meinrad Busslinger
Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.
Development (Cambridge, England) 2005;132(11):2633-43.
2005: Rosana Pelayo; Jun Hirose; Jiaxue Huang; Karla P Garrett; Alessio Delogu; Meinrad Busslinger; Paul W Kincade
Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow.
Blood 2005;105(11):4407-15.
2005: Laurence Ardouin; Antonius G Rolink; Anne-Marie Mura; Julien Gommeaux; Fritz Melchers; Meinrad Busslinger; Marie Malissen; Bernard Malissen
Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells.
European journal of immunology 2005;35(3):977-86.
2005: Esther Roldán; Martin Fuxa; Winnie Chong; Dolores Martinez; Maria Novatchkova; Meinrad Busslinger; Jane A Skok
Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene.
Nature immunology 2005;6(1):31-41.
2004: Hiromi Tagoh; Alexandra Schebesta; Pascal LeFevre; Nicola Wilson; David Hume; Meinrad Busslinger; Constanze Bonifer
Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible.
The EMBO journal 2004;23(21):4275-85.
2004: Sonja Höflinger; Kamala Kesavan; Martin Fuxa; Caroline Hutter; Barry Heavey; Freddy Radtke; Meinrad Busslinger
Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3935-44.
2004: Leping Cheng; Akiko Arata; Rumiko Mizuguchi; Ying Qian; Asanka Karunaratne; Paul A Gray; Satoru Arata; Senji Shirasawa; Maxime Bouchard; Ping Luo; Chih-Li Chen; Meinrad Busslinger; Martyn Goulding; Hiroshi Onimaru; Qiufu Ma
Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates.
Nature neuroscience 2004;7(5):510-7.
2004: Maxime Bouchard; Abdallah Souabni; Meinrad Busslinger
Tissue-specific expression of cre recombinase from the Pax8 locus.
Genesis (New York, N.Y. : 2000) 2004;38(3):105-9.
2004: Ylva Linderson; Dirk Eberhard; Stephen Malin; Annica Johansson; Meinrad Busslinger; Sven Pettersson
Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genes.
EMBO reports 2004;5(3):291-6.
2004: Martin Fuxa; Jane A Skok; Abdallah Souabni; Giorgia Salvagiotto; Esther Roldan; Meinrad Busslinger
Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene.
Genes & development 2004;18(4):411-22.
2004: Meinrad Busslinger
Transcriptional control of early B cell development.
Annual review of immunology 2004;22():55-79.
2003: Barry Heavey; Christoforos Charalambous; César Cobaleda; Meinrad Busslinger
Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factors.
The EMBO journal 2003;22(15):3887-97.
2002: Abdallah Souabni; César Cobaleda; Michael Schebesta; Meinrad Busslinger
Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1.
Immunity 2002;17(6):781-93.
2002: Maxime Bouchard; Abdallah Souabni; Markus Mandler; Annette Neubüser; Meinrad Busslinger
Nephric lineage specification by Pax2 and Pax8.
Genes & development 2002;16(22):2958-70.
2002: Michael Schebesta; Peter L Pfeffer; Meinrad Busslinger
Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene.
Immunity 2002;17(4):473-85.
2002: Ingvild Mikkola; Barry Heavey; Markus Horcher; Meinrad Busslinger
Reversion of B cell commitment upon loss of Pax5 expression.
Science (New York, N.Y.) 2002;297(5578):110-3.
2002: Michael Schebesta; Barry Heavey; Meinrad Busslinger
Transcriptional control of B-cell development.
Current opinion in immunology 2002;14(2):216-23.
2002: Peter L Pfeffer; Bernhard Payer; Gerlinde Reim; Marina Pasca di Magliano; Meinrad Busslinger
The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by separate enhancers.
Development (Cambridge, England) 2002;129(2):307-18.
2001: T Ellis; Laure Gambardella; Markus Horcher; S Tschanz; J Capol; P Bertram; W Jochum; Yann Barrandon; Meinrad Busslinger
The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle.
Genes & development 2001;15(17):2307-19.
2001: Markus Horcher; Abdallah Souabni; Meinrad Busslinger
Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.
Immunity 2001;14(6):779-90.
2001: SL Nutt; Dirk Eberhard; Markus Horcher; Antonius G Rolink; Meinrad Busslinger
Pax5 determines the identity of B cells from the beginning to the end of B-lymphopoiesis.
International reviews of immunology 2001;20(1):65-82.
2000: M Bouchard; PL Pfeffer; Meinrad Busslinger
Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development.
Development (Cambridge, England) 2000;127(17):3703-13.
2000: Dirk Eberhard; G Jiménez; Barry Heavey; Meinrad Busslinger
Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family.
The EMBO journal 2000;19(10):2292-303.
2000: Meinrad Busslinger; SL Nutt; Antonius G Rolink
Lineage commitment in lymphopoiesis.
Current opinion in immunology 2000;12(2):151-8.
2000: PL Pfeffer; M Bouchard; Meinrad Busslinger
Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary.
Development (Cambridge, England) 2000;127(5):1017-28.
1999: SL Nutt; Barry Heavey; Antonius G Rolink; Meinrad Busslinger
Commitment to the B-lymphoid lineage depends on the transcription factor Pax5.
Nature 1999;401(6753):556-62.
1999: SL Nutt; Meinrad Busslinger
Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?
Biological chemistry 1999;380(6):601-11.
1999: M Schwarz; Gonzalo Alvarez-Bolado; Gregory R Dressler; P Urbánek; Meinrad Busslinger; Peter Gruss
Pax2/5 and Pax6 subdivide the early neural tube into three domains.
Mechanisms of development 1999;82(1-2):29-39.
1999: Dirk Eberhard; Meinrad Busslinger
The partial homeodomain of the transcription factor Pax-5 (BSAP) is an interaction motif for the retinoblastoma and TATA-binding proteins.
Cancer research 1999;59(7 Suppl):1716s-1724s; discussion 1724s-1725s.
1999: SL Nutt; S Vambrie; Peter Steinlein; Zbynek Kozmik; Antonius G Rolink; Andreas Weith; Meinrad Busslinger
Independent regulation of the two Pax5 alleles during B-cell development.
Nature genetics 1999;21(4):390-5.
1999: Thomas Czerny; G Halder; Urs Kloter; Abdallah Souabni; Walter J Gehring; Meinrad Busslinger
twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development.
Molecular cell 1999;3(3):297-307.
1999: SL Nutt; Antonius G Rolink; Meinrad Busslinger
The molecular basis of B-cell lineage commitment.
Cold Spring Harbor symposia on quantitative biology 1999;64():51-9.
1999: Antonius G Rolink; SL Nutt; Meinrad Busslinger; E ten Boekel; Thomas Seidl; J Andersson; Fritz Melchers
Differentiation, dedifferentiation, and redifferentiation of B-lineage lymphocytes: roles of the surrogate light chain and the Pax5 gene.
Cold Spring Harbor symposia on quantitative biology 1999;64():21-5.
1998: AM Morrison; Ulrich Jäger; Andreas Chott; Michael Schebesta; Oskar A Haas; Meinrad Busslinger
Deregulated PAX-5 transcription from a translocated IgH promoter in marginal zone lymphoma.
Blood 1998;92(10):3865-78.
1998: C Thévenin; SL Nutt; Meinrad Busslinger
Early function of Pax5 (BSAP) before the pre-B cell receptor stage of B lymphopoiesis.
The Journal of experimental medicine 1998;188(4):735-44.
1998: PL Pfeffer; T Gerster; K Lun; M Brand; Meinrad Busslinger
Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function.
Development (Cambridge, England) 1998;125(16):3063-74.
1998: Paolo Emidio Macchia; Paola Lapi; Heiko Krude; MT Pirro; Caterina Missero; Luca Chiovato; Abdallah Souabni; Mariangiola Baserga; Vittorio Tassi; Aldo Pinchera; Gianfranco Fenzi; Annette Grüters; Meinrad Busslinger; Roberto Di Lauro
PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis.
Nature genetics 1998;19(1):83-6.
1998: SL Nutt; AM Morrison; P Dörfler; Antonius G Rolink; Meinrad Busslinger
Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments.
The EMBO journal 1998;17(8):2319-33.
1998: AM Morrison; SL Nutt; C Thévenin; Antonius G Rolink; Meinrad Busslinger
Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation.
Seminars in immunology 1998;10(2):133-42.
1997: M Schwarz; Gonzalo Alvarez-Bolado; P Urbánek; Meinrad Busslinger; Peter Gruss
Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: evidence from targeted mutations.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14518-23.
1997: SL Nutt; C Thévenin; Meinrad Busslinger
Essential functions of Pax-5 (BSAP) in pro-B cell development.
Immunobiology 1997;198(1-3):227-35.
1997: Zbynek Kozmik; Thomas Czerny; Meinrad Busslinger
Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8.
The EMBO journal 1997;16(22):6793-803.
1997: Thomas Czerny; M Bouchard; Zbynek Kozmik; Meinrad Busslinger
The characterization of novel Pax genes of the sea urchin and Drosophila reveal an ancient evolutionary origin of the Pax2/5/8 subfamily.
Mechanisms of development 1997;67(2):179-92.
1997: W F Brandt; S U Schwager; J A Rodrigues; Meinrad Busslinger
Isolation and amino acid sequence analysis reveal an ancient evolutionary origin of the cleavage stage (CS) histones of the sea urchin.
European journal of biochemistry / FEBS 1997;247(3):784-91.
1997: P Urbánek; I Fetka; Miriam H Meisler; Meinrad Busslinger
Cooperation of Pax2 and Pax5 in midbrain and cerebellum development.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(11):5703-8.
1997: B Mandl; W F Brandt; G Superti-Furga; P G Graninger; Max L Birnstiel; Meinrad Busslinger
The five cleavage-stage (CS) histones of the sea urchin are encoded by a maternally expressed family of replacement histone genes: functional equivalence of the CS H1 and frog H1M (B4) proteins.
Molecular and cellular biology 1997;17(3):1189-200.
1997: SL Nutt; P Urbánek; Antonius G Rolink; Meinrad Busslinger
Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.
Genes & development 1997;11(4):476-91.
1996: Meinrad Busslinger; N Klix; P Pfeffer; P G Graninger; Zbynek Kozmik
Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):6129-34.
1996: P Dörfler; Meinrad Busslinger
C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.
The EMBO journal 1996;15(8):1971-82.
1996: Irene Fialka; H Schwarz; E Reichmann; M Oft; Meinrad Busslinger; H Beug
The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions.
The Journal of cell biology 1996;132(6):1115-32.
1995: Meinrad Busslinger; P Urbánek
The role of BSAP (Pax-5) in B-cell development.
Current opinion in genetics & development 1995;5(5):595-601.
1995: A Reikerstorfer; H Holz; Hendrik G Stunnenberg; Meinrad Busslinger
Low affinity binding of interleukin-1 beta and intracellular signaling via NF-kappa B identify Fit-1 as a distant member of the interleukin-1 receptor family.
The Journal of biological chemistry 1995;270(30):17645-8.
1995: G Bergers; P Graninger; S Braselmann; C Wrighton; Meinrad Busslinger
Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron.
Molecular and cellular biology 1995;15(7):3748-58.
1995: Zbynek Kozmik; Ulrich Sure; D Rüedi; Meinrad Busslinger; Adriano Aguzzi
Deregulated expression of PAX5 in medulloblastoma.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5709-13.
1995: Thomas Czerny; Meinrad Busslinger
DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5).
Molecular and cellular biology 1995;15(5):2858-71.
1995: P Stapleton; Zbynek Kozmik; Andreas Weith; Meinrad Busslinger
The gene coding for the B cell surface protein CD19 is localized on human chromosome 16p11.
Human genetics 1995;95(2):223-5.
1995: Igor Vorechovský; S Koskinen; Roberto Paganelli; C I Smith; Meinrad Busslinger; L Hammarström
The PAX5 gene: a linkage and mutation analysis in candidate human primary immunodeficiencies.
Immunogenetics 1995;42(2):149-52.
1994: P Urbánek; Z Q Wang; I Fetka; E F Wagner; Meinrad Busslinger
Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP.
Cell 1994;79(5):901-12.
1994: Beat W Schäfer; Thomas Czerny; Michele Bernasconi; M Genini; Meinrad Busslinger
Molecular cloning and characterization of a human PAX-7 cDNA expressed in normal and neoplastic myocytes.
Nucleic acids research 1994;22(22):4574-82.
1994: Igor Vorechovský; R Kurzbauer; Z Kozmík; Lennart Hammarström; C I Edvard Smith; Meinrad Busslinger
SSCP/SacI polymorphism in the PAX5 gene.
Human molecular genetics 1994;3(5):839.
1994: Igor Vorechovský; Z Kozmík; Lennart Hammarström; C I Edvard Smith; Meinrad Busslinger
An intragenic TaqI RFLP at the PAX5 locus.
Human molecular genetics 1994;3(4):681.
1994: G Bergers; A Reikerstorfer; S Braselmann; P Graninger; Meinrad Busslinger
Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor.
The EMBO journal 1994;13(5):1176-88.
1993: Zbynek Kozmik; R Kurzbauer; P Dörfler; Meinrad Busslinger
Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties.
Molecular and cellular biology 1993;13(10):6024-35.
1993: Thomas Czerny; G Schaffner; Meinrad Busslinger
DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.
Genes & development 1993;7(10):2048-61.
1993: C Wrighton; Meinrad Busslinger
Direct transcriptional stimulation of the ornithine decarboxylase gene by Fos in PC12 cells but not in fibroblasts.
Molecular and cellular biology 1993;13(8):4657-69.
1993: P Stapleton; Andreas Weith; P Urbánek; Zbynek Kozmik; Meinrad Busslinger
Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9.
Nature genetics 1993;3(4):292-8.
1993: S Braselmann; P Graninger; Meinrad Busslinger
A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):1657-61.
1992: E Reichmann; H Schwarz; E M Deiner; I Leitner; M Eilers; J Berger; Meinrad Busslinger; H Beug
Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion.
Cell 1992;71(7):1103-16.
1992: B Adams; P Dörfler; Adriano Aguzzi; Zbynek Kozmik; P Urbánek; I Maurer-Fogy; Meinrad Busslinger
Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.
Genes & development 1992;6(9):1589-607.
1992: Zbynek Kozmik; S Wang; P Dörfler; B Adams; Meinrad Busslinger
The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.
Molecular and cellular biology 1992;12(6):2662-72.
1992: S Braselmann; G Bergers; C Wrighton; P Graninger; G Superti-Furga; Meinrad Busslinger
Identification of Fos target genes by the use of selective induction systems.
Journal of cell science. Supplement 1992;16():97-109.
1991: G Superti-Furga; G Bergers; D Picard; Meinrad Busslinger
Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5114-8.
1990: Alcide Barberis; K Widenhorn; L Vitelli; Meinrad Busslinger
A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.
Genes & development 1990;4(5):849-59.
1989: Alcide Barberis; G Superti-Furga; Meinrad Busslinger
The testis-specific octamer-binding protein of the sea urchin has a molecular weight of 85 kDa.
Nucleic acids research 1989;17(17):7114.
1989: M L Birnstiel; Meinrad Busslinger
Dangerous liaisons: spermatozoa as natural vectors for foreign DNA?
Cell 1989;57(5):701-2.
1989: Alcide Barberis; G Superti-Furga; L Vitelli; I Kemler; Meinrad Busslinger
Developmental and tissue-specific regulation of a novel transcription factor of the sea urchin.
Genes & development 1989;3(5):663-75.
1989: G Superti-Furga; Alcide Barberis; E Schreiber; Meinrad Busslinger
The protein CDP, but not CP1, footprints on the CCAAT region of the gamma-globin gene in unfractionated B-cell extracts.
Biochimica et biophysica acta 1989;1007(2):237-42.
1989: C Southgate; Meinrad Busslinger
In vivo and in vitro expression of U7 snRNA genes: cis- and trans-acting elements required for RNA polymerase II-directed transcription.
The EMBO journal 1989;8(2):539-49.
1988: G Superti-Furga; Alcide Barberis; G Schaffner; Meinrad Busslinger
The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene.
The EMBO journal 1988;7(10):3099-107.
1988: J Cosson; I Kemler; S Tanno; Meinrad Busslinger
Promoter of a somatic histone H2B gene of the sea urchin.
Nucleic acids research 1988;16(9):4175.
1988: L Vitelli; I Kemler; B Lauber; Max L Birnstiel; Meinrad Busslinger
Developmental regulation of micro-injected histone genes in sea urchin embryos.
Developmental biology 1988;127(1):54-63.
1987: Alcide Barberis; G Superti-Furga; Meinrad Busslinger
Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter.
Cell 1987;50(3):347-59.
1986: I Kemler; Meinrad Busslinger
Characterization of two nonallelic pairs of late histone H2A and H2B genes of the sea urchin: differential regulation in the embryo and tissue-specific expression in the adult.
Molecular and cellular biology 1986;6(11):3746-54.
1985: Meinrad Busslinger; Alcide Barberis
Synthesis of sperm and late histone cDNAs of the sea urchin with a primer complementary to the conserved 3' terminal palindrome: evidence for tissue-specific and more general histone gene variants.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(17):5676-80.
1982: Meinrad Busslinger; S Rusconi; Max L Birnstiel
An unusual evolutionary behaviour of a sea urchin histone gene cluster.
The EMBO journal 1982;1(1):27-33.