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Roger Busson

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Martin Kögler; Thierry Louat; Hélène Munier-Lehmann; Jef Rozenski; Kristien Van Belle; Roger Busson; Steven De Jonghe; Piet Herdewijn
Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.
Wen Li; Sandra Matthijs; Jef Rozenski; Guan-Lin Xie; Roger Busson; Pierre Cornelis; Paulina Estrada-de Los Santos; René De Mot
Promysalin, a salicylate-containing Pseudomonas putida antibiotic, promotes surface colonization and selectively targets other Pseudomonas.
Satish K Chitneni; Lucette Garreau; Bernard J Cleynhens; Nele Evens; Marva Bex; Peter Vermaelen; Sylvie Chalon; Roger Busson; Denis Guilloteau; Koen Van Laere; Alfons Verbruggen; Guy Bormans
Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [(18)F]FECT.

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2012: Martin Kögler; Thierry Louat; Hélène Munier-Lehmann; Jef Rozenski; Kristien Van Belle; Roger Busson; Steven De Jonghe; Piet Herdewijn
Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.
Chemistry & biodiversity 2012;9(3):536-56.
2011: Wen Li; Sandra Matthijs; Jef Rozenski; Guan-Lin Xie; Roger Busson; Pierre Cornelis; Paulina Estrada-de Los Santos; René De Mot
Promysalin, a salicylate-containing Pseudomonas putida antibiotic, promotes surface colonization and selectively targets other Pseudomonas.
Chemistry & biology 2011;18(10):1320-30.
2008: Satish K Chitneni; Lucette Garreau; Bernard J Cleynhens; Nele Evens; Marva Bex; Peter Vermaelen; Sylvie Chalon; Roger Busson; Denis Guilloteau; Koen Van Laere; Alfons Verbruggen; Guy Bormans
Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [(18)F]FECT.
Nuclear medicine and biology 2008;35(1):75-82.
2007: Arnaud Marchand; Damien Marchand; Roger Busson; Philipe Marlière; Piet Herdewijn
Synthesis of a pyridoxine-peptide based delivery system for nucleotides.
Chemistry & biodiversity 2007;4(7):1450-65.
2006: Ulrik Hillaert; Swetlana Boldin-Adamsky; Jef Rozenski; Roger Busson; Anthony H Futerman; Serge Van Calenbergh
Synthesis and biological evaluation of novel PDMP analogues.
Bioorganic & medicinal chemistry 2006;14(15):5273-84.
2005: Ding Zhou; Irene M Lagoja; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Piet Herdewijn
Synthesis and properties of aminopropyl nucleic acids.
Chembiochem : a European journal of chemical biology 2005;6(12):2298-304.
2005: Ivo Crnolatac; Ann Huygens; Arthur Van Aerschot; Roger Busson; Jef Rozenski; Peter A M De Witte
Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives.
Bioorganic & medicinal chemistry 2005;13(23):6347-53.
2005: Tongfei Wu; Matheus Froeyen; Veerle Kempeneers; Christophe Pannecouque; Jing Wang; Roger Busson; Erik De Clercq; Piet Herdewijn
Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents.
Journal of the American Chemical Society 2005;127(14):5056-65.
2004: Veerle Vanheusden; Hélène Munier-Lehmann; Matheus Froeyen; Roger Busson; Jef Rozenski; Piet Herdewijn; Serge Van Calenbergh
Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Journal of medicinal chemistry 2004;47(25):6187-94.
2004: Kris Morreel; John Ralph; Fachuang Lu; goeminne geert; Roger Busson; Piet Herdewijn; Jan Goeman; Johan Van der Eycken; Wout Boerjan; Eric Messens
Phenolic profiling of caffeic acid O-methyltransferase-deficient poplar reveals novel benzodioxane oligolignols.
Plant physiology 2004;136(4):4023-36.
2004: Veerle Vanheusden; Roger Busson; Piet Herdewijn; Serge Van Calenbergh
Synthesis and conformational analysis of 1-[2,4-dideoxy-4-C-hydroxymethyl-alpha-l-lyxopyranosyl]thymine.
The Journal of organic chemistry 2004;69(13):4446-53.
2004: Fabian Léon; Maurits Van Boven; Peter De Witte; Roger Busson; Marnix Cokelaere
Isolation and identification of molecular species of phosphatidylcholine and lysophosphatidylcholine from jojoba seed meal (Simmondsia chinensis).
Journal of agricultural and food chemistry 2004;52(5):1207-11.
2004: Tongfei Wu; Matheus Froeyen; Guy Schepers; Kristof Mullens; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Piet Herdewijn
Synthesis and stability of oligonucleotides containing acyclic achiral nucleoside analogues with two base moieties.
Organic letters 2004;6(1):51-4.
2003: Koen Nauwelaerts; Karen Vastmans; Matheus Froeyen; Veerle Kempeneers; Jef Rozenski; Helmut Rosemeyer; Arthur Van Aerschot; Roger Busson; Jeffrey C Lacey; Ekaterina V Efimtseva; Sergey N Mikhailov; Eveline Lescrinier; Piet Herdewijn
Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside.
Nucleic acids research 2003;31(23):6758-69.
2003: Veerle Vanheusden; Hélène Munier-Lehmann; Matheus Froeyen; Laurence Dugué; Arne Heyerick; Denis De Keukeleire; Sylvie Pochet; Roger Busson; Piet Herdewijn; Serge Van Calenbergh
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Journal of medicinal chemistry 2003;46(18):3811-21.
2003: Jing Wang; Dolores Viña; Roger Busson; Piet Herdewijn
Stereocontrolled synthesis of ara-type cyclohexenyl nucleosides.
The Journal of organic chemistry 2003;68(11):4499-505.
2003: Arthur Van Aerschot; Arnaud Marchand; Guy Schepers; W Van den Eynde; Jef Rozenski; Roger Busson; Piet Herdewijn
Methylated hexitol nucleic acids, towards congeners with improved antisense potential.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1227-9.
2003: Ekaterina V Efimtseva; Sergey N Mikhailov; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Piet Herdewijn
Chemical incorporation of 1-methyladenosine, minor tRNA component, into oligonucleotides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1113-5.
2003: Arthur Van Aerschot; Guy Schepers; Roger Busson; Johan Neyts; Erik De Clercq; Piet Herdewijn
Synthesis and antiviral evaluation of ribavirin congeners containing a hexitol moiety.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):849-51.
2003: Ping Gu; Jordi Morral; Jing Wang; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Erik De Clercq; Piet Herdewijn
Synthesis and biological evaluation of a series of new cyclohexenyl nucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):845-7.
2003: Maurits Van Boven; M Laga; Stefanie Leonard; Roger Busson; Ronald A Holser; Eddy Decuypere; Gerda Flo; Sylvia Lievens; Marnix Cokelaere
Mechanism of simmondsin decomposition during sodium hydroxide treatment.
Journal of agricultural and food chemistry 2003;51(5):1260-4.
2003: Ping Gu; Jordi Morral; Jing Wang; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Erik De Clercq; Piet Herdewijn
Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides.
Antiviral chemistry & chemotherapy 2003;14(1):31-7.
2003: Arthur Van Aerschot; Guy Schepers; Roger Busson; Jef Rozenski; Johan Neyts; Erik De Clercq; Piet Herdewijn
Ribavirin derivatives with a hexitol moiety: synthesis and antiviral evaluation.
Antiviral chemistry & chemotherapy 2003;14(1):23-30.
2002: Zhenyu Zhang; Patrick Chaltin; Arthur Van Aerschot; Jeff Lacey; Jef Rozenski; Roger Busson; Piet Herdewijn
New dsDNA binding unnatural oligopeptides with pyrimidine selectivity.
Bioorganic & medicinal chemistry 2002;10(11):3401-13.
2002: Kimani A M Kuria; Hezekiah Kibet Chepkwony; Cindy Govaerts; Eugène Roets; Roger Busson; Peter De Witte; Istvan Zupko; Georges Hoornaert; Ludo Quirynen; Louis Maes; Leen Janssens; Jos Hoogmartens; Gert Laekeman
The antiplasmodial activity of isolates from Ajuga remota.
Journal of natural products 2002;65(5):789-93.
2002: Sergey N Mikhailov; Jef Rozenski; Ekaterina V Efimtseva; Roger Busson; Arthur Van Aerschot; Piet Herdewijn
Chemical incorporation of 1-methyladenosine into oligonucleotides.
Nucleic acids research 2002;30(5):1124-31.
2002: Steven De Jonghe; Inge Lamote; Krishnan Venkataraman; Swetlana Boldin-Adamsky; Ulrik Hillaert; Jef Rozenski; Chris Hendrix; Roger Busson; Denis De Keukeleire; Serge Van Calenbergh; Anthony H Futerman; Piet Herdewijn
Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons.
The Journal of organic chemistry 2002;67(3):988-96.
2001: Luk Kerremans; Guy Schepers; Jef Rozenski; Roger Busson; Arthur Van Aerschot; Piet Herdewijn
Hybridization between "six-membered" nucleic acids: RNA as a universal information system.
Organic letters 2001;3(26):4129-32.
2001: Matheus Froeyen; Eveline Lescrinier; Luk Kerremans; Helmut Rosemeyer; Frank Seela; Birgit Verbeure; Irene M Lagoja; Jef Rozenski; Arthur Van Aerschot; Roger Busson; Piet Herdewijn
Alpha-homo-DNA and RNA form a parallel oriented non-A, non-B-type double helical structure.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(23):5183-94.
2001: Arthur Van Aerschot; M Meldgaard; Guy Schepers; F Volders; Jef Rozenski; Roger Busson; Piet Herdewijn
Improved hybridisation potential of oligonucleotides comprising O-methylated anhydrohexitol nucleoside congeners.
Nucleic acids research 2001;29(20):4187-94.
2001: Maurits Van Boven; T Leyssen; Roger Busson; Ronald A Holser; Marnix Cokelaere; Gerda Flo; Eddy Decuypere
Identification of 4,5-didemethyl-4-O-alpha-D-glucopyranosylsimmondsin and pinitol alpha-D-galactosides in jojoba seed meal (Simmondsia chinensis).
Journal of agricultural and food chemistry 2001;49(9):4278-83.
2001: Jennifer Orwa; Cindy Govaerts; Roger Busson; Eugène Roets; Ann Van Schepdael; Jos Hoogmartens
Isolation and structural characterization of colistin components.
The Journal of antibiotics 2001;54(7):595-9.
2001: Jennifer Orwa; Cindy Govaerts; Roger Busson; Eugène Roets; Ann Van Schepdael; Jos Hoogmartens
Isolation and structural characterization of polymyxin B components.
Journal of chromatography. A 2001;912(2):369-73.
2001: Guy Van den Mooter; M Wuyts; Norbert Blaton; Roger Busson; P Grobet; Patrick Augustijns; Renaat Kinget
Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrrolidone K25.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;12(3):261-9.
2000: H Meyermans; Kris Morreel; catherine Lapierre; Brigitte Pollet; A De Bruyn; Roger Busson; Piet Herdewijn; Bart Devreese; Jozef Van Beeumen; Jane M Marita; John Ralph; C Chen; B Burggraeve; Marc Van Montagu; Eric Messens; Wout Boerjan
Modifications in lignin and accumulation of phenolic glucosides in poplar xylem upon down-regulation of caffeoyl-coenzyme A O-methyltransferase, an enzyme involved in lignin biosynthesis.
The Journal of biological chemistry 2000;275(47):36899-909.
2000: Eveline Lescrinier; R Esnouf; J Schraml; Roger Busson; H Heus; C Hilbers; Piet Herdewijn
Solution structure of a HNA-RNA hybrid.
Chemistry & biology 2000;7(9):719-31.
2000: G N Thoithi; Ann Van Schepdael; Roger Busson; G Janssen; Arthur Van Aerschot; Piet Herdewijn; Eugène Roets; Jos Hoogmartens
Investigation of the kinetics of degradation of hexopyranosylated cytosine nucleosides using liquid chromatography.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):189-203.
2000: IA Kozlov; M Zielinski; B Allart; Luk Kerremans; Arthur Van Aerschot; Roger Busson; Piet Herdewijn; Leslie E Orgel
Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides.
Chemistry (Weinheim an der Bergstrasse, Germany) 2000;6(1):151-5.
1999: Steven De Jonghe; I Van Overmeire; S Poulton; Chris Hendrix; Roger Busson; Serge Van Calenbergh; Denis De Keukeleire; S Spiegel; Piet Herdewijn
Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase.
Bioorganic & medicinal chemistry letters 1999;9(21):3175-80.
1999: Steven De Jonghe; I Van Overmeire; J Gunst; A De Bruyn; Chris Hendrix; Serge Van Calenbergh; Roger Busson; Denis De Keukeleire; Jan Philippé; Piet Herdewijn
Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues.
Bioorganic & medicinal chemistry letters 1999;9(21):3159-64.
1999: Marleen Maras; A De Bruyn; Wouter Vervecken; J Uusitalo; Merja Penttilä; Roger Busson; Piet Herdewijn; Roland Contreras
In vivo synthesis of complex N-glycans by expression of human N-acetylglucosaminyltransferase I in the filamentous fungus Trichoderma reesei.
FEBS letters 1999;452(3):365-70.
1999: I A Kozlov; P K Politis; Arthur Van Aerschot; Roger Busson; P Herdewijn; Leslie E Orgel
Nonenzymatic synthesis of RNA and DNA oligomers on hexitol nucleic acid templates: the importance of the A structure.
Journal of the American Chemical Society 1999;121(12):2653-6.
1999: V Boudou; Luk Kerremans; B De Bouvere; Eveline Lescrinier; Guy Schepers; Roger Busson; Arthur Van Aerschot; Piet Herdewijn
Base pairing of anhydrohexitol nucleosides with 2,6-diaminopurine, 5-methylcytosine and uracil asbase moiety.
Nucleic acids research 1999;27(6):1450-6.
1998: T Ostrowski; B Wroblowski; Roger Busson; Jef Rozenski; Erik De Clercq; MS Bennett; JN Champness; WC Summers; Mark R Sanderson; Piet Herdewijn
5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase.
Journal of medicinal chemistry 1998;41(22):4343-53.
1997: Lies Vervoort; Guy Van den Mooter; Patrick Augustijns; Roger Busson; Suzanne Toppet; Renaat Kinget
Inulin hydrogels as carriers for colonic drug targeting: I. Synthesis and characterization of methacrylated inulin and hydrogel formation.
Pharmaceutical research 1997;14(12):1730-7.
1997: T Lescrinier; Roger Busson; H De Winter; C Hendrix; G Janssen; C Pannecouque; Jef Rozenski; Arthur Van Aerschot; P Herdewijn
alpha-Amino acids derived from ornithine as building blocks for peptide synthesis.
The journal of peptide research : official journal of the American Peptide Society 1997;49(2):183-9.
1996: L Liu; Eugène Roets; Roger Busson; Anne Vankeerberghen; G Janssen; Jos Hoogmartens
Two novel spiramycins obtained from commercial samples: isolation and elucidation of structure.
The Journal of antibiotics 1996;49(4):398-401.
1995: J Paesen; W Cypers; Roger Busson; Eugène Roets; Jos Hoogmartens
Isolation of decomposition products of tylosin using liquid chromatography.
Journal of chromatography. A 1995;699(1-2):99-106.
1994: Y Zhu; C Hendrix; Roger Busson; G Janssen; Eugène Roets; Jos Hoogmartens
Isolation and structural elucidation of an impurity of cefradine.
Journal of pharmaceutical and biomedical analysis 1994;12(9):1137-40.
1993: G G Parmentier; Roger Busson; G A Janssen; Guy P Mannaerts; H J Eyssen
Synthesis and 29-14C-labeling of 3 alpha, 7 alpha, 12 alpha-trihydroxy-27-carboxymethyl-5 beta-cholestan-26-oic acid. A bile acid occurring in peroxisomal diseases.
Steroids 1993;58(8):351-6.
1992: T Cachet; M Delrue; J Paesen; Roger Busson; Eugène Roets; Jos Hoogmartens
Analysis of erythromycin estolate by liquid chromatography.
Journal of pharmaceutical and biomedical analysis 1992;10(10-12):851-60.
1992: Koen Augustyns; F Vandendriessche; Arthur Van Aerschot; Roger Busson; C Urbanke; Piet Herdewijn
Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability.
Nucleic acids research 1992;20(18):4711-6.
1991: W Naidong; K Verresen; Roger Busson; Eugène Roets; Jos Hoogmartens
Isolation of doxycycline, 6-epidoxycycline and 2-acetyl-2- decarboxamidometacycline from commercial metacycline by preparative column liquid chromatography on silica gel.
Journal of chromatography 1991;586(1):67-72.
1991: Ann Van Schepdael; Roger Busson; H J Vanderhaeghe; P J Claes; L Verbist; Marie-Paule Mingeot-Leclercq; Robert Brasseur; Paul Tulkens
New derivatives of kanamycin B obtained by combined modifications in positions 1 and 6". Synthesis, microbiological properties, and in vitro and computer-aided toxicological evaluation.
Journal of medicinal chemistry 1991;34(4):1483-92.
1991: Marie-Paule Mingeot-Leclercq; Ann Van Schepdael; Robert Brasseur; Roger Busson; H J Vanderhaeghe; P J Claes; Paul Tulkens
New derivatives of kanamycin B obtained by modifications and substitutions in position 6''. 2. In vitro and computer-aided toxicological evaluation with respect to interactions with phosphatidylinositol.
Journal of medicinal chemistry 1991;34(4):1476-82.
1991: Ann Van Schepdael; J Delcourt; Michiel Mulier; Roger Busson; L Verbist; H J Vanderhaeghe; Marie-Paule Mingeot-Leclercq; Paul Tulkens; P J Claes
New derivatives of kanamycin B obtained by modifications and substitutions in position 6". 1. Synthesis and microbiological evaluation.
Journal of medicinal chemistry 1991;34(4):1468-75.
1990: L Jie; Arthur Van Aerschot; Jan Balzarini; G Janssen; Roger Busson; Jos Hoogmartens; E De Clercq; Piet Herdewijn
5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity.
Journal of medicinal chemistry 1990;33(9):2481-7.
1990: Eugène Roets; Roger Busson; Jos Hoogmartens
Separation of keto-enol tautomers of chlortetracycline and 4-epichlortetracycline by liquid chromatography on poly(styrene-divinylbenzene)copolymer.
Journal of pharmaceutical and biomedical analysis 1990;8(8-12):881-9.
1988: T Cachet; G Haest; Roger Busson; G Janssen; Jos Hoogmartens
Isolation of erythromycin E from commercial erythromycin.
Journal of chromatography 1988;445(1):290-4.
1987: I O Kibwage; G Janssen; Roger Busson; Jos Hoogmartens; H Vanderhaeghe; L Verbist
Identification of novel erythromycin derivatives in mother liquor concentrates of Streptomyces erythraeus.
The Journal of antibiotics 1987;40(1):1-6.
1986: Roger Busson; P J Claes; H Vanderhaeghe
Determination of the composition of gentamicin sulfates by 1H and 13C nuclear magnetic spectroscopy.
Journal - Association of Official Analytical Chemists 1986;69(4):601-8.
1985: L Verbist; P J Claes; Roger Busson; H Vanderhaeghe
Activity of C2a gentamicin.
The Journal of antimicrobial chemotherapy 1985;15(2):250-1.
1985: P C Maudgal; A M Verbruggen; E De Clercq; Roger Busson; R Bernaerts; M de Roo; C Ameye; Luc Missotten
Ocular penetration of (125I)IVDU, a radiolabeled analogue of bromovinyldeoxyuridine.
Investigative ophthalmology & visual science 1985;26(1):45-9.
1984: P J Claes; Roger Busson; H Vanderhaeghe
Determination of the component ratio of commercial gentamicins by high-performance liquid chromatography using pre-column derivatization.
Journal of chromatography 1984;298(3):445-57.
1983: L Colla; E De Clercq; Roger Busson; H Vanderhaeghe
Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
Journal of medicinal chemistry 1983;26(4):602-4.
1980: P C Maudgal; E De Clercq; J Descamps; Luc Missotten; P De Somer; Roger Busson; H Vanderhaeghe; G Verhelst; R T Walker; A S Jones
(E)-5-(2-bromovinyl)-2'-Deoxyuridine in the treatment of experimental herpes simplex keratitis.
Antimicrobial agents and chemotherapy 1980;17(1):8-12.