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Paul Nghiem

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Jingwei Cheng; Paul X Nghiem; Kelly G Paulson; Orit Rozenblatt-Rosen; James A DeCaprio
Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities.
Natalie J Miller; Shailender Bhatia; Jayasri G Iyer; Upendra Parvathaneni; Paul X Nghiem
Emerging and mechanism-based therapies for recurrent or metastatic merkel cell carcinoma.
Kelly G Paulson; Louise Schuman; Monica Sokil; E Margaret Warton; Lola Yelistratova; Maryam M Asgari; Shailender Bhatia; Astrid Blom; Jayasri G Iyer; Kotaro Nagase; Paul X Nghiem
Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage.

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2013: Jingwei Cheng; Paul X Nghiem; Kelly G Paulson; Orit Rozenblatt-Rosen; James A DeCaprio
Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities.
Journal of virology 2013;87(11):6118-26.
2013: Natalie J Miller; Shailender Bhatia; Jayasri G Iyer; Upendra Parvathaneni; Paul X Nghiem
Emerging and mechanism-based therapies for recurrent or metastatic merkel cell carcinoma.
Current treatment options in oncology 2013;14(2):249-63.
2013: Kelly G Paulson; Louise Schuman; Monica Sokil; E Margaret Warton; Lola Yelistratova; Maryam M Asgari; Shailender Bhatia; Astrid Blom; Jayasri G Iyer; Kotaro Nagase; Paul X Nghiem
Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage.
The Journal of investigative dermatology 2013;133(3):642-6.
2013: Allan H Conney; You-Rong Lou; Paul X Nghiem; George C Wagner; Jamie J Bernard; Yao-Ping Lu
Inhibition of UVB-induced nonmelanoma skin cancer: a path from tea to caffeine to exercise to decreased tissue fat.
Topics in current chemistry 2013;329():61-72.
2012: Yao-Ping Lu; Paul X Nghiem; Qing-Yun Peng; Sue Shapses; Weichung Joe Shih; George C Wagner; Jamie J Bernard; Tao Li; Yong Lin; You-Rong Lou; Allan H Conney
Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(23):9065-70.
2012: Stanley J Miller; William H Morrison; Kishwer S Nehal; Kelly C Nelson; Paul X Nghiem; Thomas Olencki; Clifford S Perlis; Ashok R Shaha; Malika Tuli; Marshall M Urist; Linda C Wang; John A Zic; Murad Alam; James S Andersen; Daniel Berg; Christopher K Bichakjian; Glen M Bowen; Richard T Cheney; L Frank Glass; Roy C Grekin; Alan L Ho; Anne Kessinger; NANETTE LIEGEOIS; Daniel D Lydiatt; Jeff Michalski
Dermatofibrosarcoma protuberans.
Journal of the National Comprehensive Cancer Network : JNCCN 2012;10(3):312-8.
2012: Shinichi Koba; Kotaro Nagase; Yutaka Narisawa; Kelly G Paulson; Andrew Tegeder; Renee Thibodeau; Jayasri G Iyer; Paul X Nghiem
Diagnostic biopsy does not commonly induce intratumoral CD8 T cell infiltration in Merkel cell carcinoma.
PloS one 2012;7(7):e41465.
2011: Kelly Paulson; Jayasri Iyer; Paul X Nghiem
Left-sided skin cancers on the arm from driving? Past and future lessons from Australia.
Journal of the American Academy of Dermatology 2011;65(6):1229.
2011: Jayasri G Iyer; Lichen Jing; David M Koelle; Ivy Lai; Joshua O Marshak; Christopher L McClurkan; Kotaro Nagase; Olga K Afanasiev; David Byrd; Joseph Carter; Lichun Dong; Erik Farrar; Denise Galloway; Kelly Paulson; Cassian Yee; Paul X Nghiem
Merkel cell polyomavirus-specific CD8⁺ and CD4⁺ T-cell responses identified in Merkel cell carcinomas and blood.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(21):6671-80.
2011: Sherry Lee; J Helen Leonard; Elizabeth P Murchison; Olga K Afanasiev; Can Alkan; David R Byrd; Gregory J Hannon; Kelly G Paulson; Paul X Nghiem
Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2011;52(3):272-5.
2011: Masaoki Kawasumi; Yong-son Kim; Sang-wahn Koo; Bianca Lemos; Douglas Levine; Isabel Longo; Yao-Ping Lu; Anna Mandinova; Aimee Angle-Zahn; James E Bradner; Adam Chen; Allan H Conney; Timothy P Heffernan; Erin Higgins; Lynh Nguyen; Miranda Schmidt; Renee Thibodeau; Paul X Nghiem
Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13716-21.
2011: Kelly G Paulson; Jayasri G Iyer; Paul X Nghiem
Asymmetric lateral distribution of melanoma and Merkel cell carcinoma in the United States.
Journal of the American Academy of Dermatology 2011;65(1):35-9.
2011: Yao-Ping Lu; Paul X Nghiem; Qing-Yun Peng; You-Rong Lou; Allan H Conney
Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice.
Cancer prevention research (Philadelphia, Pa.) 2011;4(7):1118-25.
2011: Kelly G Paulson; Jayasri G Iyer; Andrew R Tegeder; Renee Thibodeau; Janell Schelter; Shinichi Koba; David Schrama; William T Simonson; Bianca D Lemos; David R Byrd; David M Koelle; Denise A Galloway; J Helen Leonard; Margaret M Madeleine; Zsolt B Argenyi; Mary L Disis; Juergen C Becker; Michele A Cleary; Paul X Nghiem
Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(12):1539-46.
2011: Leonid Izikson; Erika Nornhold; Jayasri G Iyer; Paul X Nghiem; Nathalie C Zeitouni
Merkel cell carcinoma associated with HIV: review of 14 patients.
AIDS (London, England) 2011;25(1):119-21.
2010: Kelly G Paulson; Joseph J Carter; Lisa G Johnson; Kevin W Cahill; Jayasri G Iyer; David Schrama; Juergen C Becker; Margaret M Madeleine; Paul X Nghiem; Denise A Galloway
Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients.
Cancer research 2010;70(21):8388-97.
2010: Bianca D Lemos; Barry E Storer; Jayasri G Iyer; Jerri Linn Phillips; Christopher K Bichakjian; L Christine Fang; Timothy M Johnson; Nanette J Liegeois-Kwon; Clark C Otley; Kelly G Paulson; Merrick I Ross; Siegrid S Yu; Nathalie C Zeitouni; David R Byrd; Vernon K Sondak; Jeffrey E Gershenwald; Arthur J Sober; Paul X Nghiem
Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system.
Journal of the American Academy of Dermatology 2010;63(5):751-61.
2009: Joseph J Carter; Kelly G Paulson; Greg C Wipf; Danielle Miranda; Margaret M Madeleine; Lisa G Johnson; Bianca D Lemos; Sherry Lee; Ashley H Warcola; Jayasri G Iyer; Paul X Nghiem; Denise A Galloway
Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma.
Journal of the National Cancer Institute 2009;101(21):1510-22.
2009: Timothy P Heffernan; Masaoki Kawasumi; Alessandra Blasina; Kenna Anderes; Allan H Conney; Paul X Nghiem
ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.
The Journal of investigative dermatology 2009;129(7):1805-15.
2009: Kelly G Paulson; Bianca D Lemos; Bin Feng; Natalia Jaimes; Pablo F Peñas; Xiaohui Bi; Elizabeth Maher; Lisa Cohen; J Helen Leonard; Scott R Granter; Lynda Chin; Paul X Nghiem
Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc.
The Journal of investigative dermatology 2009;129(6):1547-55.
2009: Stanley J Miller; Murad Alam; James Andersen; Daniel Berg; Christopher K Bichakjian; Glen Bowen; Richard T Cheney; L Frank Glass; Roy C Grekin; Dennis E Hallahan; Anne Kessinger; Nancy Y Lee; NANETTE LIEGEOIS; Daniel D Lydiatt; Jeff Michalski; William H Morrison; Kishwer S Nehal; Kelly C Nelson; Paul X Nghiem; Thomas Olencki; Allan R Oseroff; Clifford S Perlis; E William Rosenberg; Ashok R Shaha; Marshall M Urist; Linda C Wang
Merkel cell carcinoma.
Journal of the National Comprehensive Cancer Network : JNCCN 2009;7(3):322-32.
2009: Eric G Bluemn; Kelly G Paulson; Erin E Higgins; Yu Sun; Paul X Nghiem; Peter S Nelson
Merkel cell polyomavirus is not detected in prostate cancers, surrounding stroma, or benign prostate controls.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2009;44(2):164-6.
2009: Kelly M Garneski; Ashley H Warcola; Qinghua Feng; Nancy B Kiviat; J Helen Leonard; Paul X Nghiem
Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors.
The Journal of investigative dermatology 2009;129(1):246-8.
2008: Bianca D Lemos; Siegrid S Yu; Paul X Nghiem
Case 19-2008: Merkel-cell carcinoma.
The New England journal of medicine 2008;359(15):1629-30; author reply 1630-1.
2008: Yao-Ping Lu; You-Rong Lou; Qing-Yun Peng; Jian-Guo Xie; Paul X Nghiem; Allan H Conney
Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice.
Cancer research 2008;68(7):2523-9.
2008: Michelle Heath; Natalia Jaimes; Bianca Lemos; Arash Mostaghimi; Linda C Wang; Pablo F Peñas; Paul X Nghiem
Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features.
Journal of the American Academy of Dermatology 2008;58(3):375-81.
2008: Kelly M Garneski; James A DeCaprio; Paul X Nghiem
Does a new polyomavirus contribute to Merkel cell carcinoma?
Genome biology 2008;9(6):228.
2007: Bianca Lemos; Paul X Nghiem
Merkel cell carcinoma: more deaths but still no pathway to blame.
The Journal of investigative dermatology 2007;127(9):2100-3.
2007: Masaoki Kawasumi; Paul X Nghiem
Chemical genetics: elucidating biological systems with small-molecule compounds.
The Journal of investigative dermatology 2007;127(7):1577-84.
2007: Kelly M Garneski; Paul X Nghiem
Merkel cell carcinoma adjuvant therapy: current data support radiation but not chemotherapy.
Journal of the American Academy of Dermatology 2007;57(1):166-9.
2007: Michelle L Heath; Paul X Nghiem
Merkel cell carcinoma: if no breslow, then what?
Journal of surgical oncology 2007;95(8):614-5.
2007: Stanley J Miller; Murad Alam; James Andersen; Daniel Berg; Christopher K Bichakjian; Glen Bowen; Richard T Cheney; Frank Glass; Roy C Grekin; James Grichnik; Anne Kessinger; Nancy Y Lee; Stuart R Lessin; Daniel D Lydiatt; Lawrence W Margolis; Jeffrey Michalski; Kishwer S Nehal; Paul X Nghiem; Allan R Oseroff; E William Rosenberg; Ashok R Shaha; Ronald J Siegle; Marshall M Urist
Dermatofibrosarcoma protuberans.
Journal of the National Comprehensive Cancer Network : JNCCN 2007;5(5):550-5.
2007: Stanley J Miller; Murad Alam; James Andersen; Daniel Berg; Christopher K Bichakjian; Glen Bowen; Richard T Cheney; Frank Glass; Roy C Grekin; James Grichnik; Anne Kessinger; Nancy Y Lee; Stuart R Lessin; Daniel D Lydiatt; Lawrence W Margolis; Jeffrey Michalski; Kishwer S Nehal; Paul X Nghiem; Allan R Oseroff; E William Rosenberg; Ashok R Shaha; Ronald J Siegle; Marshall M Urist
Basal cell and squamous cell skin cancers.
Journal of the National Comprehensive Cancer Network : JNCCN 2007;5(5):506-29.
2007: S-W Koo; Satoshi Hirakawa; Seishiro Fujii; Masaoki Kawasumi; Paul X Nghiem
Protection from photodamage by topical application of caffeine after ultraviolet irradiation.
The British journal of dermatology 2007;156(5):957-64.
2007: Sarah A Boswell; Pat P Ongusaha; Paul X Nghiem; Sam W Lee
The protective role of a small GTPase RhoE against UVB-induced DNA damage in keratinocytes.
The Journal of biological chemistry 2007;282(7):4850-8.
2006: Stanley J Miller; Murad Alam; James Andersen; Daniel Berg; Christopher K Bichakjian; Glen Bowen; Richard T Cheney; Frank Glass; Roy C Grekin; James Grichnik; Timothy M Johnson; Anne Kessinger; Nancy Y Lee; Stuart R Lessin; Daniel D Lydiatt; Lawrence W Margolis; Kishwer S Nehal; Paul X Nghiem; Allan R Oseroff; E William Rosenberg; Ashok R Shaha; Ronald J Siegle
Merkel cell carcinoma.
Journal of the National Comprehensive Cancer Network : JNCCN 2006;4(7):704-12.
2006: Sheela G Gupta; Linda C Wang; Pablo F Peñas; Martina Gellenthin; Stephanie J Lee; Paul X Nghiem
Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel cell carcinoma: The Dana-Farber experience and meta-analysis of the literature.
Archives of dermatology 2006;142(6):685-90.
2006: James E Bradner; Olivia M McPherson; Ralph Mazitschek; David Barnes-Seeman; John P Shen; Jasmeet Dhaliwal; Kristen E Stevenson; Jay L Duffner; Seung Bum Park; Donna Neuberg; Paul X Nghiem; Stuart L Schreiber; Angela N Koehler
A robust small-molecule microarray platform for screening cell lysates.
Chemistry & biology 2006;13(5):493-504.
2006: Bahar F Firoz; Stephanie J Lee; Paul X Nghiem; Abrar A Qureshi
Role of skin biopsy to confirm suspected acute graft-vs-host disease: results of decision analysis.
Archives of dermatology 2006;142(2):175-82.
2004: Erik S Zimmerman; Junjie Chen; Joshua L. Andersen; Orly Ardon; Jason L Dehart; Jana Blackett; shivani choudhary; David Camerini; Paul X Nghiem; Vicente Planelles
Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.
Molecular and cellular biology 2004;24(21):9286-94.
2004: Diego E Marra; Phillip H McKee; Paul X Nghiem
Tissue eosinophils and the perils of using skin biopsy specimens to distinguish between drug hypersensitivity and cutaneous graft-versus-host disease.
Journal of the American Academy of Dermatology 2004;51(4):543-6.
2003: M Isabel Longo; Paul X Nghiem
Merkel cell carcinoma treatment with radiation: a good case despite no prospective studies.
Archives of dermatology 2003;139(12):1641-3.
2003: Alykhan F Shamji; Paul X Nghiem; Stuart L Schreiber
Integration of growth factor and nutrient signaling: implications for cancer biology.
Molecular cell 2003;12(2):271-80.
2003: Mikhail Roshal; Baek Kim; Yonghong Zhu; Paul X Nghiem; Vicente Planelles
Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R.
The Journal of biological chemistry 2003;278(28):25879-86.
2002: Anne M Casper; Paul X Nghiem; Martin F Arlt; Thomas W Glover
ATR regulates fragile site stability.
Cell 2002;111(6):779-89.
2002: Anne Herbst; Harley A Haynes; Paul X Nghiem
The standard of care for Merkel cell carcinoma should include adjuvant radiation and lymph node surgery.
Journal of the American Academy of Dermatology 2002;46(4):640-2.
2002: Paul X Nghiem; Peter K Park; Yong-son Kim Ys; Bimal N Desai; Stuart L Schreiber
ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint.
The Journal of biological chemistry 2002;277(6):4428-34.
2002: Paul X Nghiem; Greg Pearson; Richard G Langley
Tacrolimus and pimecrolimus: from clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis.
Journal of the American Academy of Dermatology 2002;46(2):228-41.
2001: C J Choi; Paul X Nghiem
Tacrolimus ointment in the treatment of chronic cutaneous graft-vs-host disease: a case series of 18 patients.
Archives of dermatology 2001;137(9):1202-6.
2001: Paul X Nghiem; P K Park; Y Kim ; Cyrus Vaziri; Stuart L Schreiber
ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):9092-7.
2001: Paul X Nghiem
The "drug vs graft-vs-host disease" conundrum gets tougher, but there is an answer: the challenge to dermatologists.
Archives of dermatology 2001;137(1):75-6.
2001: Paul X Nghiem
"Topical immunomodulators?": introducing old friends and a new ally, tacrolimus.
Journal of the American Academy of Dermatology 2001;44(1):111-3.
2000: Paul X Nghiem
Identifying the missing link between UV and p53: the role of phosphatidyl inositol kinase-related kinases.
Journal of the American Academy of Dermatology 2000;43(4):706-7.
1994: Paul X Nghiem; T Ollick; Phyllis Gardner; Howard Schulman
Interleukin-2 transcriptional block by multifunctional Ca2+/calmodulin kinase.
Nature 1994;371(6495):347-50.
1994: X Li; Paul X Nghiem; H Schulman; Uta Francke
Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14.
Cytogenetics and cell genetics 1994;66(2):113-6.
1993: Paul X Nghiem; S M Saati; C L Martens; Phyllis Gardner; Howard Schulman
Cloning and analysis of two new isoforms of multifunctional Ca2+/calmodulin-dependent protein kinase. Expression in multiple human tissues.
The Journal of biological chemistry 1993;268(8):5471-9.
1992: J A Wagner; Thomas V McDonald; Paul X Nghiem; Anson W Lowe; Howard Schulman; Dieter C Gruenert; L Stryer; Phyllis Gardner
Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride currents.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(15):6785-9.
1992: Thomas V McDonald; Paul X Nghiem; Phyllis Gardner; C L Martens
Human lymphocytes transcribe the cystic fibrosis transmembrane conductance regulator gene and exhibit CF-defective cAMP-regulated chloride current.
The Journal of biological chemistry 1992;267(5):3242-8.
1991: D Maldonado; M Schumann; Paul X Nghiem; Y Dong; Phyllis Gardner
Prostaglandin E1 activates a chloride current in Jurkat T lymphocytes via cAMP-dependent protein kinase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(14):2965-70.
1990: T Itoh; Anjana Rao; D O'Brien; Paul X Nghiem; Harvey Cantor
Limiting dilution analysis of ontogeny of self- and allo-reactive thymocytes of C57BL/6J mouse.
Thymus 1990;16(2):89-98.