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Thomas Parsons

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Rebecca L Sayers; Liisa J Sundberg-Smith; Mauricio Rojas; Haruko Hayasaka; Thomas J Parsons; Christopher P Mack; Joan M Taylor
FRNK expression promotes smooth muscle cell maturation during vascular development and after vascular injury.
Tomás Vomastek; Marcin P Iwanicki; W Richard Burack; Divya Tiwari; Devanand Kumar; Thomas J Parsons; Michael J Weber; Vinay Kumar Nandicoori
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction.
Marcin Iwanicki; Tomas Vomastek; Robert W Tilghman; Karen H Martin; Jayashree Banerjee; Philip B Wedegaertner; Thomas J Parsons
FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts.

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2008: Rebecca L Sayers; Liisa J Sundberg-Smith; Mauricio Rojas; Haruko Hayasaka; Thomas J Parsons; Christopher P Mack; Joan M Taylor
FRNK expression promotes smooth muscle cell maturation during vascular development and after vascular injury.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(12):2115-22.
2008: Tomás Vomastek; Marcin P Iwanicki; W Richard Burack; Divya Tiwari; Devanand Kumar; Thomas J Parsons; Michael J Weber; Vinay Kumar Nandicoori
Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction.
Molecular and cellular biology 2008;28(22):6954-66.
2008: Marcin Iwanicki; Tomas Vomastek; Robert W Tilghman; Karen H Martin; Jayashree Banerjee; Philip B Wedegaertner; Thomas J Parsons
FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts.
Journal of cell science 2008;121(Pt 6):895-905.
2008: Thomas J Parsons; Jill Slack-Davis; Robert Tilghman; W Gregory Roberts
Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(3):627-32.
2008: Robert W Tilghman; Thomas J Parsons
Focal adhesion kinase as a regulator of cell tension in the progression of cancer.
Seminars in cancer biology 2008;18(1):45-52.
2007: Katherine A Owen; Fiona J Pixley; Keena S Thomas; Miguel Vicente-Manzanares; Brianne J Ray; Alan F Horwitz; Thomas J Parsons; Hilary E Beggs; E Richard Stanley; Amy H Bouton
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase.
The Journal of cell biology 2007;179(6):1275-87.
2007: Tomas Vomastek; Marcin Iwanicki; Hans-Joerg Schaeffer; Adel Tarcsafalvi; Thomas J Parsons; Michael J Weber
RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility.
Molecular and cellular biology 2007;27(23):8296-305.
2007: Mark W Mayhew; Erin D Jeffery; Nicholas E Sherman; Kristina Nelson; Joy M Polefrone; Stephen J Pratt; Jeffrey Shabanowitz; Thomas J Parsons; Jay W Fox; Donald F Hunt; Alan F Horwitz
Identification of phosphorylation sites in betaPIX and PAK1.
Journal of cell science 2007;120(Pt 22):3911-8.
2007: Haruko Hayasaka; Karen H Martin; E Daniel Hershey; Thomas J Parsons
Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene.
Journal of cellular biochemistry 2007;102(4):947-54.
2007: Xiaohong Zhang; Zhigang Yuan; Yingtao Zhang; Sarah Yong; Alexis Salas-Burgos; John Koomen; Nancy Olashaw; Thomas J Parsons; Xiang-Jiao Yang; Sharon R Dent; Tso-Pang Yao; William Stratton Lane; Edward Seto
HDAC6 modulates cell motility by altering the acetylation level of cortactin.
Molecular cell 2007;27(2):197-213.
2007: Jill K Slack-Davis; Karen H Martin; Robert W Tilghman; Marcin Iwanicki; Ethan J Ung; Christopher Autry; Michael J Luzzio; Beth Cooper; John C Kath; W Gregory Roberts; Thomas J Parsons
Cellular characterization of a novel focal adhesion kinase inhibitor.
The Journal of biological chemistry 2007;282(20):14845-52.
2006: Chen Luxenburg; Thomas J Parsons; Lia Addadi; Benjamin Geiger
Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts.
Journal of cell science 2006;119(Pt 23):4878-88.
2006: Karen H Martin; Erin D Jeffery; Pablo R Grigera; Jeffrey Shabanowitz; Donald F Hunt; Thomas J Parsons
Cortactin phosphorylation sites mapped by mass spectrometry.
Journal of cell science 2006;119(Pt 14):2851-3.
2005: Pablo R Grigera; Erin D Jeffery; Karen H Martin; Jeffrey Shabanowitz; Donald F Hunt; Thomas J Parsons
FAK phosphorylation sites mapped by mass spectrometry.
Journal of cell science 2005;118(Pt 21):4931-5.
2005: Haruko Hayasaka; Kate Simon; E Daniel Hershey; Koh-Hei Masumoto; Thomas J Parsons
FRNK, the autonomously expressed C-terminal region of focal adhesion kinase, is uniquely regulated in vascular smooth muscle: analysis of expression in transgenic mice.
Journal of cellular biochemistry 2005;95(6):1248-63.
2005: Robert W Tilghman; Jill K Slack-Davis; Natalia Sergina; Karen H Martin; Marcin Iwanicki; E Daniel Hershey; Hilary E Beggs; Louis F Reichardt; Thomas J Parsons
Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells.
Journal of cell science 2005;118(Pt 12):2613-23.
2005: Yunhao Liu; Gil M Yerushalmi; Pablo R Grigera; Thomas J Parsons
Mislocalization or reduced expression of Arf GTPase-activating protein ASAP1 inhibits cell spreading and migration by influencing Arf1 GTPase cycling.
The Journal of biological chemistry 2005;280(10):8884-92.
2004: Sarah J Parsons; Thomas J Parsons
Src family kinases, key regulators of signal transduction.
Oncogene 2004;23(48):7906-9.
2004: Laurence Bougnères; Stephen E Girardin; Scott A Weed; Andrei Karginov; Jean-Christophe Olivo-Marin; Thomas J Parsons; Philippe J Sansonetti; Guy Tran Van Nhieu
Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells.
The Journal of cell biology 2004;166(2):225-35.
2004: Scott T. Eblen; Jill K Slack-Davis; Adel Tarcsafalvi; Thomas J Parsons; Michael J Weber; Andrew D Catling
Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion.
Molecular and cellular biology 2004;24(6):2308-17.
2004: Donna J Webb; Karen Donais; Leanna Whitmore; Sheila M Thomas; Christopher E Turner; Thomas J Parsons; Alan F Horwitz
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly.
Nature cell biology 2004;6(2):154-61.
2004: Jill K Slack-Davis; Thomas J Parsons
Emerging views of integrin signaling: implications for prostate cancer.
Journal of cellular biochemistry 2004;91(1):41-6.
2003: Anne J Ridley; Martin A Schwartz; Keith Burridge; Richard A Firtel; Mark H Ginsberg; Gary G Borisy; Thomas J Parsons; Alan Rick Horwitz
Cell migration: integrating signals from front to back.
Science (New York, N.Y.) 2003;302(5651):1704-9.
2003: Peng Hou; Lourdes Estrada; Andrew W Kinley; Thomas J Parsons; Anne B Vojtek; Jerome L Gorski
Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape.
Human molecular genetics 2003;12(16):1981-93.
2003: Julie A Head; Dongyan Jiang; Min Li; Lynda J Zorn; Erik M Schaefer; Thomas J Parsons; Scott A Weed
Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.
Molecular biology of the cell 2003;14(8):3216-29.
2003: Jill K Slack-Davis; Scott T. Eblen; Maja Zecevic; Scott A Boerner; Adel Tarcsafalvi; H Bruce Diaz; Mark S Marshall; Michael J Weber; Thomas J Parsons; Andrew D Catling
PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation.
The Journal of cell biology 2003;162(2):281-91.
2003: Thomas J Parsons
Focal adhesion kinase: the first ten years.
Journal of cell science 2003;116(Pt 8):1409-16.
2003: Andrew W Kinley; Scott A Weed; Alissa M Weaver; Andrei Karginov; Eric A Bissonette; John A Cooper; Thomas J Parsons
Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion.
Current biology : CB 2003;13(5):384-93.
2002: Dorothy A Schafer; Scott A Weed; Derk Binns; Andrei Karginov; Thomas J Parsons; John A Cooper
Dynamin2 and cortactin regulate actin assembly and filament organization.
Current biology : CB 2002;12(21):1852-7.
2002: Alan Rick Horwitz; Nikki Watson; Thomas J Parsons
Breaking barriers through collaboration: the example of the Cell Migration Consortium.
Genome biology 2002;3(11):comment2011.
2002: Joshua D Rovin; Henry F Frierson; Wayne Ledinh; Thomas J Parsons; Reid B Adams
Expression of focal adhesion kinase in normal and pathologic human prostate tissues.
The Prostate 2002;53(2):124-32.
2002: Thomas J Parsons; Bruce R Zetter; Suresh Mohla
Shifting paradigms in tumor metastasis: challenges and opportunities.
Cancer biology & therapy 2002;1(5):582-5.
2002: Alissa M Weaver; John Edward Heuser; Andrei Karginov; Wei-Lih Lee; Thomas J Parsons; John A Cooper
Interaction of cortactin and N-WASp with Arp2/3 complex.
Current biology : CB 2002;12(15):1270-8.
2002: Yunhao Liu; Joost C Loijens; Karen H Martin; Andrei Karginov; Thomas J Parsons
The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly.
Molecular biology of the cell 2002;13(6):2147-56.
2002: Karen H Martin; Jill K Slack; Scott A Boerner; Clifford C Martin; Thomas J Parsons
Integrin connections map: to infinity and beyond.
Science (New York, N.Y.) 2002;296(5573):1652-3.
2002: Danshan Huang; Anthony T Cheung; Thomas J Parsons; Michael Bryer-Ash
Focal adhesion kinase (FAK) regulates insulin-stimulated glycogen synthesis in hepatocytes.
The Journal of biological chemistry 2002;277(20):18151-60.
2002: Donna J Webb; Thomas J Parsons; Alan F Horwitz
Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again.
Nature cell biology 2002;4(4):E97-100.
2002: Karen H Martin; Scott A Boerner; Thomas J Parsons
Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor "switch".
Cell motility and the cytoskeleton 2002;51(2):76-88.
2001: Scott A Weed; Thomas J Parsons
Cortactin: coupling membrane dynamics to cortical actin assembly.
Oncogene 2001;20(44):6418-34.
2001: M Fresu; Mariarita Bianchi; Thomas J Parsons; Emma Villa-Moruzzi
Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase.
The Biochemical journal 2001;358(Pt 2):407-14.
2001: MD Haskell; Jill K Slack; Thomas J Parsons; Sarah J Parsons
c-Src tyrosine phosphorylation of epidermal growth factor receptor, P190 RhoGAP, and focal adhesion kinase regulates diverse cellular processes.
Chemical reviews 2001;101(8):2425-40.
2001: Jill K Slack; Reid B Adams; Joshua D Rovin; Eric A Bissonette; C E Stoker; Thomas J Parsons
Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells.
Oncogene 2001;20(10):1152-63.
2001: Alissa M Weaver; Andrei Karginov; Andrew W Kinley; Scott A Weed; Yan Li; Thomas J Parsons; John A Cooper
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation.
Current biology : CB 2001;11(5):370-4.
2001: Joan M Taylor; Christopher P Mack; K Nolan; christopher regan; Gary K Owens; Thomas J Parsons
Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells.
Molecular and cellular biology 2001;21(5):1565-72.
2001: A Ma; Alan Richardson; Erik M Schaefer; Thomas J Parsons
Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas).
Molecular biology of the cell 2001;12(1):1-12.
2000: MT Harte; MM Macklem; Cheryl L Weidow; Thomas J Parsons; Amy H Bouton
Identification of two focal adhesion targeting sequences in the adapter molecule p130(Cas).
Biochimica et biophysica acta 2000;1499(1-2):34-48.
2000: Kenton Longenecker; B Zhang; Urszula Derewenda; Peter J Sheffield; Zbigniew Dauter; Thomas J Parsons; Y Zheng; Zygmunt S Derewenda
Structure of the BH domain from graf and its implications for Rho GTPase recognition.
The Journal of biological chemistry 2000;275(49):38605-10.
2000: Thomas J Parsons; Karen H Martin; Jill K Slack; Joan M Taylor; Scott A Weed
Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement.
Oncogene 2000;19(49):5606-13.
2000: Scott A Weed; Andrei Karginov; Dorothy A Schafer; Alissa M Weaver; Andrew W Kinley; John A Cooper; Thomas J Parsons
Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex.
The Journal of cell biology 2000;151(1):29-40.
2000: Joan M Taylor; Joshua D Rovin; Thomas J Parsons
A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes.
The Journal of biological chemistry 2000;275(25):19250-7.
1999: Alan Rick Horwitz; Thomas J Parsons
Cell migration--movin' on.
Science (New York, N.Y.) 1999;286(5442):1102-3.
1999: Michael D Schaller; J D Hildebrand; Thomas J Parsons
Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases.
Molecular biology of the cell 1999;10(10):3489-505.
1999: Jill K Slack; Andrew D Catling; Scott T. Eblen; Michael J Weber; Thomas J Parsons
c-Raf-mediated inhibition of epidermal growth factor-stimulated cell migration.
The Journal of biological chemistry 1999;274(38):27177-84.
1999: RC Wahl; R Y Hsu; J L Huff; M A Jelinek; K Chen; PL Courchesne; Scott D Patterson; Thomas J Parsons; A A Welcher
Chicken macrophage stimulating protein is a ligand of the receptor protein-tyrosine kinase Sea.
The Journal of biological chemistry 1999;274(37):26361-8.
1999: K Nolan; J Lacoste; Thomas J Parsons
Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase.
Molecular and cellular biology 1999;19(9):6120-9.
1999: Päivi Lakkakorpi; Ichiro Nakamura; Rose M Nagy; Thomas J Parsons; Gideon A Rodan; LT Duong
Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone.
The Journal of biological chemistry 1999;274(8):4900-7.
1999: Joan M Taylor; MM Macklem; Thomas J Parsons
Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho.
Journal of cell science 1999;112 ( Pt 2)():231-42.
1998: Y Du; Scott A Weed; Wencheng Xiong; T D Marshall; Thomas J Parsons
Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons.
Molecular and cellular biology 1998;18(10):5838-51.
1998: Scott A Weed; Y Du; Thomas J Parsons
Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1.
Journal of cell science 1998;111 ( Pt 16)():2433-43.
1998: Wencheng Xiong; MM Macklem; Thomas J Parsons
Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein.
Journal of cell science 1998;111 ( Pt 14)():1981-91.
1998: Joan M Taylor; J D Hildebrand; Christopher P Mack; Michael E Cox; Thomas J Parsons
Characterization of graf, the GTPase-activating protein for rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase.
The Journal of biological chemistry 1998;273(14):8063-70.
1998: J Lacoste; A Ma; Thomas J Parsons
Assay and purification and focal adhesion kinase.
Methods in enzymology 1998;298():89-102.
1998: Joan M Taylor; Alan Richardson; Thomas J Parsons
Modular domains of focal adhesion-associated proteins.
Current topics in microbiology and immunology 1998;228():135-63.
1997: Alan Richardson; RK Malik; J D Hildebrand; Thomas J Parsons
Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation.
Molecular and cellular biology 1997;17(12):6906-14.
1997: Wencheng Xiong; Thomas J Parsons
Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase.
The Journal of cell biology 1997;139(2):529-39.
1997: Alan Richardson; John D Shannon; Reid B Adams; Michael D Schaller; Thomas J Parsons
Identification of integrin-stimulated sites of serine phosphorylation in FRNK, the separately expressed C-terminal domain of focal adhesion kinase: a potential role for protein kinase A.
The Biochemical journal 1997;324 ( Pt 1)():141-9.
1997: Thomas J Parsons; Sarah J Parsons
Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways.
Current opinion in cell biology 1997;9(2):187-92.
1996: RK Malik; Thomas J Parsons
Integrin-dependent activation of the p70 ribosomal S6 kinase signaling pathway.
The Journal of biological chemistry 1996;271(47):29785-91.
1996: RK Malik; Thomas J Parsons
Integrin-mediated signaling in normal and malignant cells: a role of protein tyrosine kinases.
Biochimica et biophysica acta 1996;1287(2-3):73-6.
1996: M T Harte; J D Hildebrand; MR Burnham; Amy H Bouton; Thomas J Parsons
p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase.
The Journal of biological chemistry 1996;271(23):13649-55.
1996: MR Burnham; M T Harte; Alan Richardson; Thomas J Parsons; Amy H Bouton
The identification of p130cas-binding proteins and their role in cellular transformation.
Oncogene 1996;12(11):2467-72.
1996: J D Hildebrand; Joan M Taylor; Thomas J Parsons
An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase.
Molecular and cellular biology 1996;16(6):3169-78.
1996: Thomas J Parsons
Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins.
Current opinion in cell biology 1996;8(2):146-52.
1996: E Medico; A M Mongiovi; J Huff; M A Jelinek; Antonia Follenzi; Giovanni Gaudino; Thomas J Parsons; paolo comoglio
The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro.
Molecular biology of the cell 1996;7(4):495-504.
1996: J L Huff; M A Jelinek; T A Jamieson; Thomas J Parsons
Expression and maturation of the cellular sea receptor, a member of the hepatocyte growth factor (HGF) receptor family of protein tyrosine kinases.
Oncogene 1996;12(2):299-307.
1995: Michael D Schaller; Carol A Otey; J D Hildebrand; Thomas J Parsons
Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.
The Journal of cell biology 1995;130(5):1181-7.
1995: H C Chen; P A Appeddu; Thomas J Parsons; J D Hildebrand; Michael D Schaller; Jun-Lin Guan
Interaction of focal adhesion kinase with cytoskeletal protein talin.
The Journal of biological chemistry 1995;270(28):16995-9.
1995: J D Hildebrand; Michael D Schaller; Thomas J Parsons
Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.
Molecular biology of the cell 1995;6(6):637-47.
1995: Michael D Schaller; Thomas J Parsons
pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk.
Molecular and cellular biology 1995;15(5):2635-45.
1995: L A Petch; S M Bockholt; A Bouton; Thomas J Parsons; Keith Burridge
Adhesion-induced tyrosine phosphorylation of the p130 src substrate.
Journal of cell science 1995;108 ( Pt 4)():1371-9.
1995: Alan Richardson; Thomas J Parsons
Signal transduction through integrins: a central role for focal adhesion kinase?
BioEssays : news and reviews in molecular, cellular and developmental biology 1995;17(3):229-36.
1994: Michael D Schaller; Thomas J Parsons
Focal adhesion kinase and associated proteins.
Current opinion in cell biology 1994;6(5):705-10.
1994: M R Miglarese; J Mannion-Henderson; H Wu; Thomas J Parsons; T P Bender
The protein tyrosine kinase substrate cortactin is differentially expressed in murine B lymphoid tumors.
Oncogene 1994;9(7):1989-97.
1994: L E Marengere; Zhou Songyang; Gerald Gish; Michael D Schaller; Thomas J Parsons; Michael J Stern; L C Cantley; Tony Pawson
SH2 domain specificity and activity modified by a single residue.
Nature 1994;369(6480):502-5.
1994: M Faris; felicia gaskin; Thomas J Parsons; Shu Man Fu
CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein.
The Journal of experimental medicine 1994;179(6):1923-31.
1994: Sanford J Shattil; B Haimovich; M Cunningham; L Lipfert; Thomas J Parsons; Mark H Ginsberg; Joan S Brugge
Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.
The Journal of biological chemistry 1994;269(20):14738-45.
1994: Michael D Schaller; J D Hildebrand; John D Shannon; Jay W Fox; RR Vines; Thomas J Parsons
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.
Molecular and cellular biology 1994;14(3):1680-8.
1994: Thomas J Parsons; Michael D Schaller; J Hildebrand; Tzeng-Horng Leu; Alan Richardson; Carol A Otey
Focal adhesion kinase: structure and signalling.
Journal of cell science. Supplement 1994;18():109-13.
1994: B S Cobb; Michael D Schaller; Tzeng-Horng Leu; Thomas J Parsons
Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.
Molecular and cellular biology 1994;14(1):147-55.
1993: D C Flynn; Tzeng-Horng Leu; A B Reynolds; Thomas J Parsons
Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate.
Molecular and cellular biology 1993;13(12):7892-900.
1993: J D Hildebrand; Michael D Schaller; Thomas J Parsons
Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.
The Journal of cell biology 1993;123(4):993-1005.
1993: B S Cobb; Thomas J Parsons
Regulation of the cellular src protein tyrosine kinase: interactions of the carboxyl terminal sequences residing between the kinase domain and tyrosine-527.
Oncogene 1993;8(11):2897-903.
1993: Christopher E Turner; Michael D Schaller; Thomas J Parsons
Tyrosine phosphorylation of the focal adhesion kinase pp125FAK during development: relation to paxillin.
Journal of cell science 1993;105 ( Pt 3)():637-45.
1993: J L Huff; M A Jelinek; C A Borgman; T J Lansing; Thomas J Parsons
The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptor.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6140-4.
1993: H Wu; Thomas J Parsons
Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex.
The Journal of cell biology 1993;120(6):1417-26.
1993: Michael D Schaller; C A Borgman; Thomas J Parsons
Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK.
Molecular and cellular biology 1993;13(2):785-91.
1993: Thomas J Parsons; S J Parsons
Protein-tyrosine kinases, oncogenes, and cancer.
Important advances in oncology 1993;():3-17.
1993: Michael D Schaller; Amy H Bouton; D C Flynn; Thomas J Parsons
Identification and characterization of novel substrates for protein tyrosine kinases.
Progress in nucleic acid research and molecular biology 1993;44():205-27.
1993: Amy H Bouton; Thomas J Parsons
Retroviruses and cancer: models for cancer in animals and humans.
Cancer investigation 1993;11(1):70-9.
1992: Ming-Chei Maa; L K Wilson; J S Moyers; RR Vines; Thomas J Parsons; Sarah J Parsons
Identification and characterization of a cytoskeleton-associated, epidermal growth factor sensitive pp60c-src substrate.
Oncogene 1992;7(12):2429-38.
1992: L Kornberg; Henry Earp; Thomas J Parsons; Michael D Schaller; Rudy L Juliano
Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.
The Journal of biological chemistry 1992;267(33):23439-42.
1992: L Lipfert; B Haimovich; Michael D Schaller; B S Cobb; Thomas J Parsons; Joan S Brugge
Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.
The Journal of cell biology 1992;119(4):905-12.
1992: Michael D Schaller; C A Borgman; B S Cobb; RR Vines; A B Reynolds; Thomas J Parsons
pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):5192-6.
1992: S F Farina; J L Huff; Thomas J Parsons
Mutations within the 5' half of the avian retrovirus MC29 v-myc gene alter or abolish transformation of chicken embryo fibroblasts and macrophages.
Journal of virology 1992;66(5):2698-708.
1992: D C Flynn; Michael D Schaller; Thomas J Parsons
Tyrosine phosphorylation of a 120,000 dalton membrane-associated protein by the neural form of pp60c-src, pp60c-src+.
Oncogene 1992;7(3):579-83.
1991: B S Cobb; D M Payne; A B Reynolds; Thomas J Parsons
Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527).
Molecular and cellular biology 1991;11(12):5832-8.
1991: H Wu; A B Reynolds; S B Kanner; RR Vines; Thomas J Parsons
Identification and characterization of a novel cytoskeleton-associated pp60src substrate.
Molecular and cellular biology 1991;11(10):5113-24.
1991: S B Kanner; A B Reynolds; H C Wang; RR Vines; Thomas J Parsons
The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.
The EMBO journal 1991;10(7):1689-98.
1991: Amy H Bouton; S B Kanner; RR Vines; H C Wang; J B Gibbs; Thomas J Parsons
Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.
Molecular and cellular biology 1991;11(2):945-53.
1991: S B Kanner; A B Reynolds; Thomas J Parsons
Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells.
Molecular and cellular biology 1991;11(2):713-20.
1991: Amy H Bouton; S B Kanner; RR Vines; Thomas J Parsons
Tyrosine phosphorylation of three cellular proteins correlates with transformation of rat 1 cells by pp60src.
Molecular carcinogenesis 1991;4(2):145-52.
1990: Thomas J Parsons
Closing the GAP in a signal transduction pathway.
Trends in genetics : TIG 1990;6(6):169-71.
1990: S B Kanner; A B Reynolds; RR Vines; Thomas J Parsons
Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(9):3328-32.
1989: A B Reynolds; S B Kanner; H C Wang; Thomas J Parsons
Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins.
Molecular and cellular biology 1989;9(9):3951-8.
1989: S B Kanner; A B Reynolds; Thomas J Parsons
Immunoaffinity purification of tyrosine-phosphorylated cellular proteins.
Journal of immunological methods 1989;120(1):115-24.
1989: L K Wilson; Deidre K. Luttrell; Thomas J Parsons; Sarah J Parsons
pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src.
Molecular and cellular biology 1989;9(4):1536-44.
1989: S B Kanner; Tona M Gilmer; A B Reynolds; Thomas J Parsons
Novel tyrosine phosphorylations accompany the activation of pp60c-src during chemical carcinogenesis.
Oncogene 1989;4(3):295-300.
1989: A B Reynolds; D J Roesel; S B Kanner; Thomas J Parsons
Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.
Molecular and cellular biology 1989;9(2):629-38.
1989: H C Wang; Thomas J Parsons
Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability.
Journal of virology 1989;63(1):291-302.
1989: Thomas J Parsons; M J Weber
Genetics of src: structure and functional organization of a protein tyrosine kinase.
Current topics in microbiology and immunology 1989;147():79-127.
1988: S B Kanner; Sarah J Parsons; Thomas J Parsons; Tona M Gilmer
Activation of pp60c-src tyrosine kinase specific activity in tumor-derived Syrian hamster embryo cells.
Oncogene 1988;2(4):327-35.
1988: W M Potts; A B Reynolds; T J Lansing; Thomas J Parsons
Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95.
Oncogene research 1988;3(4):343-55.
1987: V W Raymond; Thomas J Parsons
Identification of an amino terminal domain required for the transforming activity of the Rous sarcoma virus src protein.
Virology 1987;160(2):400-10.
1987: A B Reynolds; J Vila; T J Lansing; W M Potts; Michael J Weber; Thomas J Parsons
Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.
The EMBO journal 1987;6(8):2359-64.
1987: B J Biegalke; Mark L Heaney; A Bouton; Thomas J Parsons; M Linial
MC29 deletion mutants which fail to transform chicken macrophages are competent for transformation of quail macrophages.
Journal of virology 1987;61(7):2138-42.
1987: D J McCarley; Thomas J Parsons; D C Benjamin; Sarah J Parsons
Inhibition of the tyrosine kinase activity of v-src, v-fgr, and v-yes gene products by a monoclonal antibody which binds both amino and carboxy peptide fragments of pp60v-src.
Journal of virology 1987;61(6):1927-37.
1986: Mark L Heaney; J Pierce; Thomas J Parsons
Site-directed mutagenesis of the gag-myc gene of avian myelocytomatosis virus 29: biological activity and intracellular localization of structurally altered proteins.
Journal of virology 1986;60(1):167-76.
1986: Sarah J Parsons; D J McCarley; V W Raymond; Thomas J Parsons
Localization of conserved and nonconserved epitopes within the Rous sarcoma virus-encoded src protein.
Journal of virology 1986;59(3):755-8.
1986: J H Morgan; Thomas J Parsons
Characterization of c-myc proteins from avian bursal lymphoma cell lines.
Virology 1986;150(1):178-86.
1986: Thomas J Parsons; V Wilkerson; Sarah J Parsons
Structural and functional motifs of the Rous sarcoma virus src protein.
Gene amplification and analysis 1986;4():1-19.
1985: J H Morgan; T S Papas; Thomas J Parsons
Isolation of antibodies specific for avian viral and cellular myc proteins.
Journal of the National Cancer Institute 1985;75(5):937-47.
1985: V W Wilkerson; D L Bryant; Thomas J Parsons
Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation.
Journal of virology 1985;55(2):314-21.
1985: W T Chen; J M Chen; S J Parsons; Thomas J Parsons
Local degradation of fibronectin at sites of expression of the transforming gene product pp60src.
Nature 1985;316(6024):156-8.
1984: Sarah J Parsons; D J McCarley; C M Ely; D C Benjamin; Thomas J Parsons
Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin.
Journal of virology 1984;51(2):272-82.
1984: D L Bryant; Thomas J Parsons
Amino acid alterations within a highly conserved region of the Rous sarcoma virus src gene product pp60src inactivate tyrosine protein kinase activity.
Molecular and cellular biology 1984;4(5):862-6.
1984: Sarah J Parsons; L D Wilson; C M Ely; Thomas J Parsons; D C Benjamin
Monoclonal antibodies specific for the virion polypeptide, p27, of avian retroviruses.
Hybridoma 1984;3(1):25-31.
1983: G M Gilmartin; Thomas J Parsons
Identification of transcriptional elements within the long terminal repeat of Rous sarcoma virus.
Molecular and cellular biology 1983;3(10):1834-45.
1983: D Bryant; Thomas J Parsons
Site-directed point mutation in the src gene oF rous sarcoma virus results in an inactive src gene product.
Journal of virology 1983;45(3):1211-6.
1983: Sarah J Parsons; D J McCarley; C M Ely; D C Benjamin; Thomas J Parsons
Isolation and partial characterization of a monoclonal antibody to the Rous sarcoma virus transforming protein pp60src.
Journal of virology 1983;45(3):1190-4.
1982: D Bryant; Thomas J Parsons
Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation.
Journal of virology 1982;44(2):683-91.
1982: T K Misra; Duane P Grandgenett; Thomas J Parsons
Avian retrovirus pp32 DNA-binding protein. I. Recognition of specific sequences on retrovirus DNA terminal repeats.
Journal of virology 1982;44(1):330-43.
1982: T M Gilmer; Thomas J Parsons; Raymond L. Erikson
Construction of plasmids for expression of Rous sarcoma virus transforming protein, p60src, in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(7):2152-6.
1981: C A Omer; Thomas J Parsons; A J Faras
Direct proof of the 5' to 3' transcriptional jump during reverse transcription of the avian retrovirus genome by DNA sequencing.
Journal of virology 1981;38(1):398-402.
1980: P E Highfield; L F Rafield; T M Gilmer; Thomas J Parsons
Molecular cloning of avian sarcoma virus closed circular DNA: structural and biological characterization of three recombinant clones.
Journal of virology 1980;36(1):271-9.
1980: C J Collins; D Boettiger; T L Green; M B Burgess; H Devlin; Thomas J Parsons
Arrangement of integrated avian sarcoma virus DNA sequences within the cellular genomes of transformed and revertant mammalian cells.
Journal of virology 1980;33(2):760-8.
1979: T M Gilmer; Thomas J Parsons
Analysis of cellular integration sites in avian sarcoma virus infected duck embryo cells.
Journal of virology 1979;32(3):762-9.
1979: P M Dierks; P E Highfield; Thomas J Parsons
Deletion mutant of the Bratislava-77 strain of Rous sarcoma virus containing a fusion of the group-specific antigen and envelope genes.
Journal of virology 1979;32(2):567-82.
1979: S J Parsons; S C Riley; E E Mullen; E J Brock; D C Benjamin; W M Kuehl; Thomas J Parsons
Immune response to the src gene product in mice bearing tumors induced by injection of avian sarcoma virus-transformed mouse cells.
Journal of virology 1979;32(1):40-6.
1978: Thomas J Parsons; P Lewis; P Dierks
Purification of virus-specific RNA from chicken cells infected with avian sarcoma virus: identification of genome-length and subgenome-leghth viral RNAs.
Journal of virology 1978;27(1):227-38.
1978: Marc S Collett; P Dierks; Thomas J Parsons; A J Faras
RNase H hydrolysis of the 5' terminus of the avian sarcoma virus genome during reverse transcription.
Nature 1978;272(5649):181-4.
1978: J P Leis; R E Smith; P Dierks; Thomas J Parsons; Marc S Collett; A J Faras
In vitro transcription of reconstituted 35s RNA.tRNAtrp template.primer complexes by the avian oncornavirus DNA polymerase. Effect of temperature on the size of the DNA transcripts.
Virology 1978;85(1):28-42.
1977: C J Collins; Thomas J Parsons
Integration of avian sarcoma virus DNA sequences in transformed mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(10):4301-5.
1977: S U Emerson; P M Dierks; Thomas J Parsons
In vitro synthesis of a unique RNA species by a T particle of vesicular stomatitis virus.
Journal of virology 1977;23(3):708-16.
1977: Marc S Collett; P Dierks; J F Cahill; A J Faras; Thomas J Parsons
Terminally repeated sequences in the avian sarcoma virus RNA genome.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(6):2389-93.
1975: C Weissmann; Thomas J Parsons; J W Coffin; L Rymo; Martin Alfred Billeter; H Hofstetter
Studies on the structure and synthesis of Rous sarcoma virus RNA.
Cold Spring Harbor symposia on quantitative biology 1975;39 Pt 2():1043-56.
1974: Martin Alfred Billeter; Thomas J Parsons; John M Coffin
The nucleotide sequence complexity of avian tumor virus RNA.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(9):3560-4.
1974: L Rymo; Thomas J Parsons; John M Coffin; C Weissmann
In vitro synthesis of Rous sarcoma virus-specific RNA is catalyzed by a DNA-dependent RNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America 1974;71(7):2782-6.
1974: John M Coffin; Thomas J Parsons; L Rymo; R K Haroz; C Weissmann
A new approach to the isolation of RNA-DNA hybrids and its application to the quantitative determination of labeled tumor virus RNA.
Journal of molecular biology 1974;86(2):373-96.
1973: Thomas J Parsons; John M Coffin; R K Haroz; P A Bromley; C Weissmann
Quantitative determination and location of newly synthesized virus-specific ribonucleic acid in chicken cells infected with Rous sarcoma virus.
Journal of virology 1973;11(5):761-74.
1971: Thomas J Parsons; M Green
Biochemical studies on adenovirus multiplication. 18. Resolution of early virus-specific RNA species in Ad 2 infected and transformed cells.
Virology 1971;45(1):154-62.
1970: K Fujinaga; Thomas J Parsons; J W Beard; D Beard; M Green
Mechanism of carcinogenesis by RNA tumor viruses. 3. Formation of RNA, DNA complex and duplex DNA molecules by the DNA polymerase (s) of avian myeloblastosis virus.
Proceedings of the National Academy of Sciences of the United States of America 1970;67(3):1432-9.