Hartmut Jaeschke

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Schüngel Sven; Buitrago-Molina Laura Elisa; Nalapareddy Padmavathi devi; Lebofsky Margitta; Manns Michael P; Jaeschke Hartmut; Gross Atan; Vogel Arndt
The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers.
Hong Ji-Young; Lebofsky Margitta; Farhood Anwar; Jaeschke Hartmut
Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation.
Uchiyama Akira; Kim Jae-Sung; Kon Kazuyoshi; Jaeschke Hartmut; Ikejima Kenichi; Watanabe Sumio; Lemasters John J
Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury.

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2009: Schüngel Sven; Buitrago-Molina Laura Elisa; Nalapareddy Padmavathi devi; Lebofsky Margitta; Manns Michael P; Jaeschke Hartmut; Gross Atan; Vogel Arndt
The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers.
Hepatology (Baltimore, Md.) 2009;50(5):1558-66.
2009: Hong Ji-Young; Lebofsky Margitta; Farhood Anwar; Jaeschke Hartmut
Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(3):G572-81.
2008: Uchiyama Akira; Kim Jae-Sung; Kon Kazuyoshi; Jaeschke Hartmut; Ikejima Kenichi; Watanabe Sumio; Lemasters John J
Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury.
Hepatology (Baltimore, Md.) 2008;48(5):1644-54.
2008: Jaeschke Hartmut
Innate immunity and acetaminophen-induced liver injury: why so many controversies?
Hepatology (Baltimore, Md.) 2008;48(3):699-701.
2008: Bajt Mary Lynn; Yan Hui-Min; Farhood Anwar; Jaeschke Hartmut
Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose.
Toxicological sciences : an official journal of the Society of Toxicology 2008;104(2):419-27.
2008: Andringa Kelly K; Bajt Mary Lynn; Jaeschke Hartmut; Bailey Shannon M
Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase.
Toxicology letters 2008;177(3):188-97.
2008: Bajt Mary Lynn; Farhood Anwar; Lemasters John J; Jaeschke Hartmut
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 2008;324(1):8-14.
2007: Wagner Martin; Zollner Gernot; Fickert Peter; Gumhold Judith; Silbert Dagmar; Fuchsbichler Andrea; Gujral Jaspreet S; Zatloukal Kurt; Denk Helmut; Jaeschke Hartmut; Trauner Michael
Hepatobiliary transporter expression in intercellular adhesion molecule 1 knockout and Fas receptor-deficient mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(9):1694-9.
2007: Fickert Peter; Stöger Ulrike; Fuchsbichler Andrea; Moustafa Tarek; Marschall Hanns-Ulrich; Weiglein Andreas H; Tsybrovskyy Oleksiy; Jaeschke Hartmut; Zatloukal Kurt; Denk Helmut; Trauner Michael
A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis.
The American journal of pathology 2007;171(2):525-36.
2007: Jaeschke Hartmut; Liu Jie
Neutrophil depletion protects against murine acetaminophen hepatotoxicity: another perspective.
Hepatology (Baltimore, Md.) 2007;45(6):1588-9; author reply 1589.
2007: Jaeschke Hartmut
Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury?
Toxicological sciences : an official journal of the Society of Toxicology 2007;97(1):1-3.
2007: Hasegawa Tadashi; Ito Yoshiya; Wijeweera Jayanthika; Liu Jie; Malle Ernst; Farhood Anwar; McCuskey Robert S; Jaeschke Hartmut
Reduced inflammatory response and increased microcirculatory disturbances during hepatic ischemia-reperfusion injury in steatotic livers of ob/ob mice.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(5):G1385-95.
2007: Ramaiah Shashi K; Jaeschke Hartmut
Role of neutrophils in the pathogenesis of acute inflammatory liver injury.
Toxicologic pathology 2007;35(6):757-66.
2006: Bajt Mary Lynn; Cover Cathleen; Lemasters John J; Jaeschke Hartmut
Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury.
Toxicological sciences : an official journal of the Society of Toxicology 2006;94(1):217-25.
2006: Jaeschke Hartmut; Hasegawa Tadashi
Role of neutrophils in acute inflammatory liver injury.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(8):912-9.
2006: Cover Cathleen; Liu Jie; Farhood Anwar; Malle Ernst; Waalkes Michael P; Bajt Mary Lynn; Jaeschke Hartmut
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity.
Toxicology and applied pharmacology 2006;216(1):98-107.
2006: Ito Yoshiya; Abril Edward R; Bethea Nancy W; McCuskey Margaret K; Cover Cathleen; Jaeschke Hartmut; McCuskey Robert S
Mechanisms and pathophysiological implications of sinusoidal endothelial cell gap formation following treatment with galactosamine/endotoxin in mice.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(2):G211-8.
2006: Jaeschke Hartmut
How relevant are neutrophils for acetaminophen hepatotoxicity?
Hepatology (Baltimore, Md.) 2006;43(6):1191-4.
2006: Jaeschke Hartmut
Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(6):G1083-8.
2006: Jaeschke Hartmut; Cover Cathleen; Bajt Mary Lynn
Role of caspases in acetaminophen-induced liver injury.
Life sciences 2006;78(15):1670-6.
2006: Fickert Peter; Wagner Martin; Marschall Hanns-Ulrich; Fuchsbichler Andrea; Zollner Gernot; Tsybrovskyy Oleksiy; Zatloukal Kurt; Liu Jie; Waalkes Michael P; Cover Cathleen; Denk Helmut; Hofmann Alan F; Jaeschke Hartmut; Trauner Michael
24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.
Gastroenterology 2006;130(2):465-81.
2006: Fickert Peter; Fuchsbichler Andrea; Marschall Hanns-Ulrich; Wagner Martin; Zollner Gernot; Krause Robert; Zatloukal Kurt; Jaeschke Hartmut; Denk Helmut; Trauner Michael
Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.
The American journal of pathology 2006;168(2):410-22.
2006: Jaeschke Hartmut; Bajt Mary Lynn
Intracellular signaling mechanisms of acetaminophen-induced liver cell death.
Toxicological sciences : an official journal of the Society of Toxicology 2006;89(1):31-41.
2005: Cover Cathleen; Mansouri Abdellah; Knight Tamara R; Bajt Mary Lynn; Lemasters John J; Pessayre Dominique; Jaeschke Hartmut
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 2005;315(2):879-87.
2005: Jaeschke Hartmut
Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity.
Expert opinion on drug metabolism & toxicology 2005;1(3):389-97.
2005: Hasegawa Tadashi; Malle Ernst; Farhood Anwar; Jaeschke Hartmut
Generation of hypochlorite-modified proteins by neutrophils during ischemia-reperfusion injury in rat liver: attenuation by ischemic preconditioning.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(4):G760-7.
2005: Jaeschke Hartmut
Comments on "glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells".
The Journal of pharmacology and experimental therapeutics 2005;314(3):1401-2; author reply 1403-4.
2005: Dorman Robert B; Gujral Jaspreet S; Bajt Mary Lynn; Farhood Anwar; Jaeschke Hartmut
Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(5):G880-6.
2005: Cover Cathleen; Fickert Peter; Knight Tamara R; Fuchsbichler Andrea; Farhood Anwar; Trauner Michael; Jaeschke Hartmut
Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2005;84(1):201-8.
2004: Jaeschke Hartmut; Bajt Mary Lynn
Critical role of CXC chemokines in endotoxemic liver injury in mice.
Journal of leukocyte biology 2004;76(6):1089-90; author reply 1091-2.
2004: Kon Kazuyoshi; Kim Jae-Sung; Jaeschke Hartmut; Lemasters John J
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes.
Hepatology (Baltimore, Md.) 2004;40(5):1170-9.
2004: Gujral Jaspreet S; Liu Jie; Farhood Anwar; Jaeschke Hartmut
Reduced oncotic necrosis in Fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation.
Hepatology (Baltimore, Md.) 2004;40(4):998-1007.
2004: Bajt Mary Lynn; Knight Tamara R; Lemasters John J; Jaeschke Hartmut
Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine.
Toxicological sciences : an official journal of the Society of Toxicology 2004;80(2):343-9.
2004: Gujral Jaspreet S; Hinson Jack A; Farhood Anwar; Jaeschke Hartmut
NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia.
American journal of physiology. Gastrointestinal and liver physiology 2004;287(1):G243-52.
2004: Jaeschke Hartmut; Gujral Jaspreet S; Bajt Mary Lynn
Apoptosis and necrosis in liver disease.
Liver international : official journal of the International Association for the Study of the Liver 2004;24(2):85-9.
2004: Gujral Jaspreet S; Liu Jie; Farhood Anwar; Hinson Jack A; Jaeschke Hartmut
Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice.
American journal of physiology. Gastrointestinal and liver physiology 2004;286(3):G499-507.
2003: James Laura P; McCullough Sandra S; Knight Tamara R; Jaeschke Hartmut; Hinson Jack A
Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress.
Free radical research 2003;37(12):1289-97.
2003: Knight Tamara R; Fariss Marc W; Farhood Anwar; Jaeschke Hartmut
Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2003;76(1):229-36.
2003: Jaeschke Helmut
Are cultured liver cells the right tool to investigate mechanisms of liver disease or hepatotoxicity?
Hepatology (Baltimore, Md.) 2003;38(4):1053-5.
2003: Jaeschke Hartmut; Lemasters John J
Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury.
Gastroenterology 2003;125(4):1246-57.
2003: Bajt Mary Lynn; Knight Tamara R; Farhood Anwar; Jaeschke Hartmut
Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice.
The Journal of pharmacology and experimental therapeutics 2003;307(1):67-73.
2003: Li Chengxiu; Liu Jie; Waalkes Michael P; Jaeschke Hartmut
Gene array analysis of the hepatic response to endotoxin in glutathione peroxidase-deficient mice.
Toxicology letters 2003;144(3):397-406.
2003: Jaeschke Hartmut; Knight Tamara R; Bajt Mary Lynn
The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity.
Toxicology letters 2003;144(3):279-88.
2003: Gujral Jaspreet S; Farhood Anwar; Bajt Mary Lynn; Jaeschke Hartmut
Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice.
Hepatology (Baltimore, Md.) 2003;38(2):355-63.
2003: Gujral Jaspreet S; Farhood Anwar; Jaeschke Hartmut
Oncotic necrosis and caspase-dependent apoptosis during galactosamine-induced liver injury in rats.
Toxicology and applied pharmacology 2003;190(1):37-46.
2003: Paxian Markus; Bauer Inge; Rensing Hauke; Jaeschke Hartmut; Mautes Angelika E M; Kolb Stefan A; Wolf Beate; Stockhausen Andre; Jeblick Silke; Bauer Michael
Recovery of hepatocellular ATP and "pericentral apoptosis" after hemorrhage and resuscitation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):993-1002.
2003: Jaeschke Hartmut
Role of reactive oxygen species in hepatic ischemia-reperfusion injury and preconditioning.
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2003;16(3):127-40.
2003: Jaeschke Hartmut
Involvement of Kupffer cells in the interaction between neutrophils and sinusoidal endothelial cells in rats. Shock 18(2):152-157, 2002.
Shock (Augusta, Ga.) 2003;19(4):394-5; author reply 395-6.
2003: Jaeschke Hartmut; Bajt Mary Lynn
Regulation of apoptotic signaling pathways in hepatocytes in vivo.
Hepatology (Baltimore, Md.) 2003;37(4):942-5.
2003: Jaeschke Hartmut
Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(1):G15-26.
2002: Jaeschke H
Reperfusion injury after warm ischemia or cold storage of the liver: role of apoptotic cell death.
Transplantation proceedings 2002;34(7):2656-8.
2002: Knight Tamara R; Ho Ye-Shih; Farhood Anwar; Jaeschke Hartmut
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione.
The Journal of pharmacology and experimental therapeutics 2002;303(2):468-75.
2002: Bajt Mary Lynn; Ho Ye-Shih; Vonderfecht Steven L; Jaeschke Hartmut
Reactive oxygen as modulator of TNF and fas receptor-mediated apoptosis in vivo: studies with glutathione peroxidase-deficient mice.
Antioxidants & redox signaling 2002;4(5):733-40.
2002: Jaeschke Hartmut
Redox considerations in hepatic injury and inflammation.
Antioxidants & redox signaling 2002;4(5):699-700.
2002: Jaeschke Hartmut
Xanthine oxidase-induced oxidant stress during hepatic ischemia-reperfusion: are we coming full circle after 20 years?
Hepatology (Baltimore, Md.) 2002;36(3):761-3.
2002: Jaeschke Hartmut; Farhood Anwar
Kupffer cell activation after no-flow ischemia versus hemorrhagic shock.
Free radical biology & medicine 2002;33(2):210-9.
2002: Jaeschke Hartmut
Antioxidant gene therapy and hepatic ischemia-reperfusion injury.
Hepatology (Baltimore, Md.) 2002;36(1):243-5.
2002: Knight Tamara R; Jaeschke Hartmut
Acetaminophen-induced inhibition of Fas receptor-mediated liver cell apoptosis: mitochondrial dysfunction versus glutathione depletion.
Toxicology and applied pharmacology 2002;181(2):133-41.
2002: Gujral Jaspreet S; Knight Tamara R; Farhood Anwar; Bajt Mary Lynn; Jaeschke Hartmut
Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?
Toxicological sciences : an official journal of the Society of Toxicology 2002;67(2):322-8.
2002: Jaeschke Hartmut
Neutrophil-mediated tissue injury in alcoholic hepatitis.
Alcohol (Fayetteville, N.Y.) 2002;27(1):23-7.
2002: Jaeschke Hartmut
Inflammation in response to hepatocellular apoptosis.
Hepatology (Baltimore, Md.) 2002;35(4):964-6.
2002: Jaeschke Hartmut; Gores Gregory J; Cederbaum Arthur I; Hinson Jack A; Pessayre Dominique; Lemasters John J
Mechanisms of hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2002;65(2):166-76.
2001: Bajt M L; Farhood A; Jaeschke H
Effects of CXC chemokines on neutrophil activation and sequestration in hepatic vasculature.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(5):G1188-95.
2001: Rensing H; Jaeschke H; Bauer I; Pätau C; Datene V; Pannen B H; Bauer M
Differential activation pattern of redox-sensitive transcription factors and stress-inducible dilator systems heme oxygenase-1 and inducible nitric oxide synthase in hemorrhagic and endotoxic shock.
Critical care medicine 2001;29(10):1962-71.
2001: Bajt M L; Vonderfecht S L; Jaeschke H
Differential protection with inhibitors of caspase-8 and caspase-3 in murine models of tumor necrosis factor and Fas receptor-mediated hepatocellular apoptosis.
Toxicology and applied pharmacology 2001;175(3):243-52.
2001: Knight T R; Kurtz A; Bajt M L; Hinson J A; Jaeschke H
Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress.
Toxicological sciences : an official journal of the Society of Toxicology 2001;62(2):212-20.
2001: Gujral J S; Bucci T J; Farhood A; Jaeschke H
Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: apoptosis or necrosis?
Hepatology (Baltimore, Md.) 2001;33(2):397-405.
2000: Jaeschke H; Farhood A; Cai S X; Tseng B Y; Bajt M L
Protection against TNF-induced liver parenchymal cell apoptosis during endotoxemia by a novel caspase inhibitor in mice.
Toxicology and applied pharmacology 2000;169(1):77-83.
2000: Bajt M L; Lawson J A; Vonderfecht S L; Gujral J S; Jaeschke H
Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8.
Toxicological sciences : an official journal of the Society of Toxicology 2000;58(1):109-17.
2000: Lawson J A; Burns A R; Farhood A; Lynn Bajt M; Collins R G; Smith C W; Jaeschke H
Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in mice.
Hepatology (Baltimore, Md.) 2000;32(5):990-8.
2000: Bauer I; Vollmar B; Jaeschke H; Rensing H; Kraemer T; Larsen R; Bauer M
Transcriptional activation of heme oxygenase-1 and its functional significance in acetaminophen-induced hepatitis and hepatocellular injury in the rat.
Journal of hepatology 2000;33(3):395-406.
2000: Jaeschke H
Reactive oxygen and mechanisms of inflammatory liver injury.
Journal of gastroenterology and hepatology 2000;15(7):718-24.
2000: Lawson J A; Farhood A; Hopper R D; Bajt M L; Jaeschke H
The hepatic inflammatory response after acetaminophen overdose: role of neutrophils.
Toxicological sciences : an official journal of the Society of Toxicology 2000;54(2):509-16.
1999: Jaeschke H
Kupffer cell-induced oxidant stress during hepatic ischemia-reperfusion: does the controversy continue?
Hepatology (Baltimore, Md.) 1999;30(6):1527-8.
1999: Rensing H; Bauer I; Peters I; Wein T; Silomon M; Jaeschke H; Bauer M
Role of reactive oxygen species for hepatocellular injury and heme oxygenase-1 gene expression after hemorrhage and resuscitation.
Shock (Augusta, Ga.) 1999;12(4):300-8.
1999: Jaeschke H
Is anti-P-selectin therapy effective in hepatic ischemia-reperfusion injury because it inhibits neutrophil recruitment?
Shock (Augusta, Ga.) 1999;12(3):233-4.
1999: Bilzer M; Jaeschke H; Vollmar A M; Paumgartner G; Gerbes A L
Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide.
The American journal of physiology 1999;276(5 Pt 1):G1137-44.
1999: Lawson J A; Fisher M A; Simmons C A; Farhood A; Jaeschke H
Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice.
Toxicology and applied pharmacology 1999;156(3):179-86.
1999: Jaeschke H; Ho Y S; Fisher M A; Lawson J A; Farhood A
Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress.
Hepatology (Baltimore, Md.) 1999;29(2):443-50.
1998: Lawson J A; Fisher M A; Simmons C A; Farhood A; Jaeschke H
Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury.
Hepatology (Baltimore, Md.) 1998;28(3):761-7.
1998: Wang Y; Lawson J A; Jaeschke H
Differential effect of 2-aminoethyl-isothiourea, an inhibitor of the inducible nitric oxide synthase, on microvascular blood flow and organ injury in models of hepatic ischemia-reperfusion and endotoxemia.
Shock (Augusta, Ga.) 1998;10(1):20-5.
1998: Chosay J G; Fisher M A; Farhood A; Ready K A; Dunn C J; Jaeschke H
Role of PECAM-1 (CD31) in neutrophil transmigration in murine models of liver and peritoneal inflammation.
The American journal of physiology 1998;274(4 Pt 1):G776-82.
1998: Jaeschke H; Fisher M A; Lawson J A; Simmons C A; Farhood A; Jones D A
Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3480-6.
1998: Essani N A; Fisher M A; Simmons C A; Hoover J L; Farhood A; Jaeschke H
Increased P-selectin gene expression in the liver vasculature and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock.
Journal of leukocyte biology 1998;63(3):288-96.
1998: Jaeschke H
Mechanisms of reperfusion injury after warm ischemia of the liver.
Journal of hepato-biliary-pancreatic surgery 1998;5(4):402-8.
1997: Jaeschke H; Smith C W
Cell adhesion and migration. III. Leukocyte adhesion and transmigration in the liver vasculature.
The American journal of physiology 1997;273(6 Pt 1):G1169-73.
1997: Jaeschke H
Cellular adhesion molecules: regulation and functional significance in the pathogenesis of liver diseases.
The American journal of physiology 1997;273(3 Pt 1):G602-11.
1997: Jaeschke H; Smith C W
Mechanisms of neutrophil-induced parenchymal cell injury.
Journal of leukocyte biology 1997;61(6):647-53.
1997: Essani N A; Bajt M L; Farhood A; Vonderfecht S L; Jaeschke H
Transcriptional activation of vascular cell adhesion molecule-1 gene in vivo and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5941-8.
1997: Chosay J G; Essani N A; Dunn C J; Jaeschke H
Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxin-induced injury.
The American journal of physiology 1997;272(5 Pt 1):G1195-200.
1997: Essani N A; Fisher M A; Jaeschke H
Inhibition of NF-kappa B activation by dimethyl sulfoxide correlates with suppression of TNF-alpha formation, reduced ICAM-1 gene transcription, and protection against endotoxin-induced liver injury.
Shock (Augusta, Ga.) 1997;7(2):90-6.
1997: Jaeschke H
Chemokines and liver inflammation: the battle between pro- and anti-inflammatory mediators.
Hepatology (Baltimore, Md.) 1997;25(1):252-3.
1996: Jaeschke H
Chemokines, neutrophils, and inflammatory liver injury.
Shock (Augusta, Ga.) 1996;6(6):403-4.
1996: Jaeschke H; Farhood A; Fisher M A; Smith C W
Sequestration of neutrophils in the hepatic vasculature during endotoxemia is independent of beta 2 integrins and intercellular adhesion molecule-1.
Shock (Augusta, Ga.) 1996;6(5):351-6.
1996: Jaeschke H
Preservation injury: mechanisms, prevention and consequences.
Journal of hepatology 1996;25(5):774-80.
1996: McKenna R; Laskey R E; Wang Y; Jaeschke H; Mathews W R
Effect of endotoxin-enhanced hepatic reperfusion injury on endothelium-dependent relaxation in rat aorta.
Shock (Augusta, Ga.) 1996;6(2):106-11.
1996: Jaeschke H; Smith C W; Clemens M G; Ganey P E; Roth R A
Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils.
Toxicology and applied pharmacology 1996;139(2):213-26.
1996: Wang Y; Mathews W R; Guido D M; Jaeschke H
The 21-aminosteroid tirilazad mesylate protects against liver injury via membrane stabilization not inhibition of lipid peroxidation.
The Journal of pharmacology and experimental therapeutics 1996;277(2):714-20.
1996: Essani N A; McGuire G M; Manning A M; Jaeschke H
Endotoxin-induced activation of the nuclear transcription factor kappa B and expression of E-selectin messenger RNA in hepatocytes, Kupffer cells, and endothelial cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(8):2956-63.
1996: Jaeschke H; Essani N A; Fisher M A; Vonderfecht S L; Farhood A; Smith C W
Release of soluble intercellular adhesion molecule 1 into bile and serum in murine endotoxin shock.
Hepatology (Baltimore, Md.) 1996;23(3):530-6.
1996: McGuire G M; Liu P; Jaeschke H
Neutrophil-induced lung damage after hepatic ischemia and endotoxemia.
Free radical biology & medicine 1996;20(2):189-97.
1995: Wang Y; Mathews W R; Guido D M; Farhood A; Jaeschke H
Inhibition of nitric oxide synthesis aggravates reperfusion injury after hepatic ischemia and endotoxemia.
Shock (Augusta, Ga.) 1995;4(4):282-8.
1995: Hillesheim W; Jaeschke H; Neumann H G
Cytotoxicity of aromatic amines in rat liver and oxidative stress.
Chemico-biological interactions 1995;98(1):85-95.
1995: Jaeschke H
Mechanisms of oxidant stress-induced acute tissue injury.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1995;209(2):104-11.
1995: Essani N A; Fisher M A; Farhood A; Manning A M; Smith C W; Jaeschke H
Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure.
Hepatology (Baltimore, Md.) 1995;21(6):1632-9.
1995: Essani N A; McGuire G M; Manning A M; Jaeschke H
Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cells during endotoxemia.
Biochemical and biophysical research communications 1995;211(1):74-82.
1995: Farhood A; McGuire G M; Manning A M; Miyasaka M; Smith C W; Jaeschke H
Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver.
Journal of leukocyte biology 1995;57(3):368-74.
1995: Liu P; McGuire G M; Fisher M A; Farhood A; Smith C W; Jaeschke H
Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia.
Shock (Augusta, Ga.) 1995;3(1):56-62.
1994: Liu P; Vonderfecht S L; McGuire G M; Fisher M A; Farhood A; Jaeschke H
The 21-aminosteroid tirilazad mesylate protects against endotoxin shock and acute liver failure in rats.
The Journal of pharmacology and experimental therapeutics 1994;271(1):438-45.
1994: Jaeschke H
Pathophysiology of hepatic ischemia-reperfusion injury: the role of complement activation.
Gastroenterology 1994;107(2):583-6.
1994: Mathews W R; Guido D M; Fisher M A; Jaeschke H
Lipid peroxidation as molecular mechanism of liver cell injury during reperfusion after ischemia.
Free radical biology & medicine 1994;16(6):763-70.
1994: Liu P; Fisher M A; Farhood A; Smith C W; Jaeschke H
Beneficial effects of extracellular glutathione against endotoxin-induced liver injury during ischemia and reperfusion.
Circulatory shock 1994;43(2):64-70.
1994: Liu P; Vonderfecht S L; Fisher M A; McGuire G M; Jaeschke H
Priming of phagocytes for reactive oxygen production during hepatic ischemia-reperfusion potentiates the susceptibility for endotoxin-induced liver injury.
Circulatory shock 1994;43(1):9-17.
1994: Jaeschke H; Farhood A; Smith C W
Contribution of complement-stimulated hepatic macrophages and neutrophils to endotoxin-induced liver injury in rats.
Hepatology (Baltimore, Md.) 1994;19(4):973-9.
1994: Bautista A P; Spolarics Z; Jaeschke H; Smith C W; Spitzer J J
Antineutrophil monoclonal antibody (1F12) alters superoxide anion release by neutrophils and Kupffer cells.
Journal of leukocyte biology 1994;55(3):328-35.
1994: Witthaut R; Farhood A; Smith C W; Jaeschke H
Complement and tumor necrosis factor-alpha contribute to Mac-1 (CD11b/CD18) up-regulation and systemic neutrophil activation during endotoxemia in vivo.
Journal of leukocyte biology 1994;55(1):105-11.
1994: Jaeschke H
[Pathogenetic mechanisms of acute liver failure]
Zentralblatt für Chirurgie 1994;119(5):309-16.
1994: Chang J; Jaeschke H; Randerath K
Effect of Ni(II) on tissue hydrogen peroxide content in mice as inferred from glutathione and glutathione disulfide measurements.
Life sciences 1994;55(23):1789-96.
1993: Jaeschke H
The therapeutic potential of glutathione in hepatic ischemia-reperfusion injury.
Transplantation 1993;56(1):256-7.
1993: Jaeschke H; Farhood A; Bautista A P; Spolarics Z; Spitzer J J; Smith C W
Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver.
Hepatology (Baltimore, Md.) 1993;17(5):915-23.
1993: Bautista A P; Spolarics Z; Jaeschke H; Smith C W; Spitzer J J
Monoclonal antibody against the CD18 adhesion molecule stimulates glucose uptake by the liver and hepatic nonparenchymal cells.
Hepatology (Baltimore, Md.) 1993;17(5):924-31.
1993: Jaeschke H; Farhood A; Bautista A P; Spolarics Z; Spitzer J J
Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia.
The American journal of physiology 1993;264(4 Pt 1):G801-9.
1992: Jaeschke H; Raftery M J; Justesen U; Gaskell S J
Serum complement mediates endotoxin-induced cysteinyl leukotriene formation in rats in vivo.
The American journal of physiology 1992;263(6 Pt 1):G947-52.
1992: Jaeschke H
Commentary on 'Isolated cells in the study of the molecular mechanisms of reperfusion injury' by H. de Groot.
Toxicology letters 1992;63(2):107-10.
1992: Raftery M J; Justesen U; Jaeschke H; Gaskell S J
Mass spectrometric quantification of cysteine-containing leukotrienes in rat bile using 13C-labeled internal standards.
Biological mass spectrometry 1992;21(10):509-16.
1992: Jaeschke H; Bautista A P; Spolarics Z; Spitzer J J
Superoxide generation by neutrophils and Kupffer cells during in vivo reperfusion after hepatic ischemia in rats.
Journal of leukocyte biology 1992;52(4):377-82.
1992: Jaeschke H; Benzick A E
Pathophysiological consequences of enhanced intracellular superoxide formation in isolated perfused rat liver.
Chemico-biological interactions 1992;84(1):55-68.
1992: Jaeschke H
Enhanced sinusoidal glutathione efflux during endotoxin-induced oxidant stress in vivo.
The American journal of physiology 1992;263(1 Pt 1):G60-8.
1992: Hughes H; Farhood A; Jaeschke H
Role of leukotriene B4 in the pathogenesis of hepatic ischemia-reperfusion injury in the rat.
Prostaglandins, leukotrienes, and essential fatty acids 1992;45(2):113-9.
1992: Jaeschke H; Kleinwaechter C; Wendel A
NADH-dependent reductive stress and ferritin-bound iron in allyl alcohol-induced lipid peroxidation in vivo: the protective effect of vitamin E.
Chemico-biological interactions 1992;81(1-2):57-68.
1992: Jaeschke H; Schini V B; Farhood A
Role of nitric oxide in the oxidant stress during ischemia/reperfusion injury of the liver.
Life sciences 1992;50(23):1797-804.
1991: Jaeschke H; Farhood A; Smith C W
Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism.
The American journal of physiology 1991;261(6 Pt 1):G1051-6.
1991: Jaeschke H; Farhood A
Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver.
The American journal of physiology 1991;260(3 Pt 1):G355-62.
1991: Jaeschke H; Benzick A E; Smith C V; Mitchell J R
The pathophysiological significance of reactive oxygen formation in rat liver.
Advances in experimental medicine and biology 1991;283():295-8.
1991: Jaeschke H
Vascular oxidant stress and hepatic ischemia/reperfusion injury.
Free radical research communications 1991;12-13 Pt 2():737-43.
1991: Jaeschke H
Reactive oxygen and ischemia/reperfusion injury of the liver.
Chemico-biological interactions 1991;79(2):115-36.
1991: Jaeschke H; Bautista A P; Spolarics Z; Spitzer J J
Superoxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia.
Free radical research communications 1991;15(5):277-84.
1990: Jaeschke H
Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol.
The Journal of pharmacology and experimental therapeutics 1990;255(3):935-41.
1990: Jaeschke H; Farhood A; Smith C W
Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(15):3355-9.
1990: Kehrer J P; Jones D P; Lemasters J J; Farber J L; Jaeschke H
Mechanisms of hypoxic cell injury. Summary of the symposium presented at the 1990 annual meeting of the Society of Toxicology.
Toxicology and applied pharmacology 1990;106(2):165-78.
1990: Jaeschke H
Glutathione disulfide as index of oxidant stress in rat liver during hypoxia.
The American journal of physiology 1990;258(4 Pt 1):G499-505.
1990: Jaeschke H
The pathophysiological significance of increased tight-junctional permeability during oestrogen cholestasis.
The Biochemical journal 1990;266(2):620-2.
1990: Jaeschke H; Mitchell J R
Use of isolated perfused organs in hypoxia and ischemia/reperfusion oxidant stress.
Methods in enzymology 1990;186():752-9.
1990: Hughes H; Jaeschke H; Mitchell J R
Measurement of oxidant stress in vivo.
Methods in enzymology 1990;186():681-5.
1989: Spalding D J; Mitchell J R; Jaeschke H; Smith C V
Diquat hepatotoxicity in the Fischer-344 rat: the role of covalent binding to tissue proteins and lipids.
Toxicology and applied pharmacology 1989;101(2):319-27.
1989: Ammon H P; Klumpp S; Fuss A; Verspohl E J; Jaeschke H; Wendel A; Müller P
A possible role of plasma glutathione in glucose-mediated insulin secretion: in vitro and in vivo studies in rats.
Diabetologia 1989;32(11):797-800.
1989: Jaeschke H; Mitchell J R
Mitochondria and xanthine oxidase both generate reactive oxygen species in isolated perfused rat liver after hypoxic injury.
Biochemical and biophysical research communications 1989;160(1):140-7.
1989: Smith C V; Jaeschke H
Effect of acetaminophen on hepatic content and biliary efflux of glutathione disulfide in mice.
Chemico-biological interactions 1989;70(3-4):241-8.
1988: Jaeschke H; Wendel A
Choleresis and increased biliary efflux of glutathione induced by phenolic antioxidants in rats.
Toxicology 1988;52(3):225-35.
1988: Jaeschke H; Smith C V; Mitchell J R
Reactive oxygen species during ischemia-reflow injury in isolated perfused rat liver.
The Journal of clinical investigation 1988;81(4):1240-6.
1988: Jaeschke H; Smith C V; Mitchell J R
Hypoxic damage generates reactive oxygen species in isolated perfused rat liver.
Biochemical and biophysical research communications 1988;150(2):568-74.
1987: Jaeschke H; Trummer E; Krell H
Increase in biliary permeability subsequent to intrahepatic cholestasis by estradiol valerate in rats.
Gastroenterology 1987;93(3):533-8.
1987: Jaeschke H; Krell H; Pfaff E
Quantitative estimation of transcellular and paracellular pathways of biliary sucrose in isolated perfused rat liver.
The Biochemical journal 1987;241(3):635-40.
1987: Jaeschke H; Kleinwaechter C; Wendel A
The role of acrolein in allyl alcohol-induced lipid peroxidation and liver cell damage in mice.
Biochemical pharmacology 1987;36(1):51-7.
1987: Jaeschke H; Werner C; Wendel A
Disposition and hepatoprotection by phosphatidyl choline liposomes in mouse liver.
Chemico-biological interactions 1987;64(1-2):127-37.
1987: Krell H; Metz J; Jaeschke H; Höke H; Pfaff E
Drug-induced intrahepatic cholestasis: characterization of different pathomechanisms.
Archives of toxicology 1987;60(1-3):124-30.
1987: Mitchell J R; Smith C V; Hughes H; Lenz M L; Jaeschke H; Shappell S B; Michael L H; Entman M L
No evidence for reactive oxygen damage in ischemia-reflow injury.
Transactions of the Association of American Physicians 1987;100():54-61.
1986: Jaeschke H; Wendel A
Manipulation of mouse organ glutathione contents. II: Time and dose-dependent induction of the glutathione conjugation system by phenolic antioxidants.
Toxicology 1986;39(1):59-70.
1985: Krell H; Jaeschke H; Pfaff E
Regulation of canalicular bile formation by alpha-adrenergic action and by external ATP in the isolated perfused rat liver.
Biochemical and biophysical research communications 1985;131(1):139-45.
1985: Jaeschke H; Wendel A
Manipulation of mouse organ glutathione contents I: Enhancement by oral administration of butylated hydroxyanisole and butylated hydroxytoluene.
Toxicology 1985;36(1):77-85.
1985: Jaeschke H; Wendel A
Diurnal fluctuation and pharmacological alteration of mouse organ glutathione content.
Biochemical pharmacology 1985;34(7):1029-33.
1983: Jaeschke H; Krell H; Pfaff E
No increase of biliary permeability in ethinylestradiol-treated rats.
Gastroenterology 1983;85(4):808-14.
1982: Wendel A; Jaeschke H
Drug-induced lipid peroxidation in mice--III. Glutathione content of liver, kidney and spleen after intravenous administration of free and liposomally entrapped glutathione.
Biochemical pharmacology 1982;31(22):3607-11.
1982: Wendel A; Jaeschke H; Gloger M
Drug-induced lipid peroxidation in mice--II. Protection against paracetamol-induced liver necrosis by intravenous liposomally entrapped glutathione.
Biochemical pharmacology 1982;31(22):3601-5.

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