Guy Sauvageau

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Sabry Waleed; Le Blanc Richard; Labbé Annie-Claude; Sauvageau Guy; Couban Stephen; Kiss Thomas; Busque Lambert; Cohen Sandra; Lachance Silvy; Roy Denis-Claude; Roy Jean
Graft-versus-host disease prophylaxis with tacrolimus and mycophenolate mofetil in HLA-matched nonmyeloablative transplant recipients is associated with very low incidence of GVHD and nonrelapse mortality.
Deneault Eric; Cellot Sonia; Faubert Amélie; Laverdure Jean-Philippe; Fréchette Mélanie; Chagraoui Jalila; Mayotte Nadine; Sauvageau Martin; Ting Stephen B; Sauvageau Guy
A functional screen to identify novel effectors of hematopoietic stem cell activity.
Bilodeau Mélanie; MacRae Tara; Gaboury Louis; Laverdure Jean-Philippe; Hardy Marie-Pierre; Mayotte Nadine; Paradis Véronique; Harton Sébastien; Perreault Claude; Sauvageau Guy
Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1.

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2009: Sabry Waleed; Le Blanc Richard; Labbé Annie-Claude; Sauvageau Guy; Couban Stephen; Kiss Thomas; Busque Lambert; Cohen Sandra; Lachance Silvy; Roy Denis-Claude; Roy Jean
Graft-versus-host disease prophylaxis with tacrolimus and mycophenolate mofetil in HLA-matched nonmyeloablative transplant recipients is associated with very low incidence of GVHD and nonrelapse mortality.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009;15(8):919-29.
2009: Deneault Eric; Cellot Sonia; Faubert Amélie; Laverdure Jean-Philippe; Fréchette Mélanie; Chagraoui Jalila; Mayotte Nadine; Sauvageau Martin; Ting Stephen B; Sauvageau Guy
A functional screen to identify novel effectors of hematopoietic stem cell activity.
Cell 2009;137(2):369-79.
2009: Bilodeau Mélanie; MacRae Tara; Gaboury Louis; Laverdure Jean-Philippe; Hardy Marie-Pierre; Mayotte Nadine; Paradis Véronique; Harton Sébastien; Perreault Claude; Sauvageau Guy
Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1.
PloS one 2009;4(10):e7500.
2008: Sauvageau Guy; Perreault Claude
Killer granzyme B linked to N-myc- and c-myc-dependent HSC survival: isn't that comyc?
Cell stem cell 2008;3(6):579-80.
2008: Bijl J; Krosl J; Lebert-Ghali C-E; Vacher J; Mayotte N; Sauvageau G
Evidence for Hox and E2A-PBX1 collaboration in mouse T-cell leukemia.
Oncogene 2008;27(49):6356-64.
2008: Louis Isabelle; Heinonen Krista M; Chagraoui Jalila; Vainio Seppo; Sauvageau Guy; Perreault Claude
The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling.
Immunity 2008;29(1):57-67.
2008: Sauvageau Martin; Sauvageau Guy
Polycomb group genes: keeping stem cell activity in balance.
PLoS biology 2008;6(4):e113.
2008: Sauvageau Martin; Miller Michelle; Lemieux Sébastien; Lessard Julie; Hébert Josée; Sauvageau Guy
Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia.
Blood 2008;111(2):790-9.
2008: Faubert A; Chagraoui J; Mayotte N; Fréchette M; Iscove N N; Humphries R K; Sauvageau G
Complementary and independent function for Hoxb4 and Bmi1 in HSC activity.
Cold Spring Harbor symposia on quantitative biology 2008;73():555-64.
2007: Labbé Annie-Claude; Su Shi Hann; Laverdière Michel; Pépin Jacques; Patiño Carlos; Cohen Sandra; Kiss Thomas; Lachance Silvy; Sauvageau Guy; Busque Lambert; Roy Denis-Claude; Roy Jean
High incidence of invasive aspergillosis associated with intestinal graft-versus-host disease following nonmyeloablative transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(10):1192-200.
2007: Ohta Hideaki; Sekulovic Sanja; Bakovic Silvia; Eaves Connie J; Pineault Nicolas; Gasparetto Maura; Smith Clayton; Sauvageau Guy; Humphries R Keith
Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions.
Experimental hematology 2007;35(5):817-30.
2007: Cellot Sonia; Krosl Jana; Chagraoui Jalila; Meloche Sylvain; Humphries R Keith; Sauvageau Guy
Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells.
Experimental hematology 2007;35(5):802-16.
2007: Cellot Sonia; Sauvageau Guy
Zfx: at the crossroads of survival and self-renewal.
Cell 2007;129(2):239-41.
2007: Bilodeau Mélanie; Girard Simon; Hébert Josée; Sauvageau Guy
A retroviral strategy that efficiently creates chromosomal deletions in mammalian cells.
Nature methods 2007;4(3):263-8.
2006: Cellot S; Sauvageau G
In vitro stem cell expansion: stepping closer towards self-renewal.
Gene therapy 2006;13(23):1617-8.
2006: Bilodeau Mélanie; Sauvageau Guy
Uncovering stemness.
Nature cell biology 2006;8(10):1048-9.
2006: Chagraoui Jalila; Niessen Sherry L; Lessard Julie; Girard Simon; Coulombe Philippe; Sauvageau Martin; Meloche Sylvain; Sauvageau Guy
E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.
Genes & development 2006;20(15):2110-20.
2006: Mamo Aline; Krosl Jana; Kroon Evert; Bijl Janet; Thompson Alexander; Mayotte Nadine; Girard Simon; Bisaillon Richard; Beslu Nathalie; Featherstone Mark; Sauvageau Guy
Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation.
Blood 2006;108(2):622-9.
2006: Bijl Janet; Thompson Alexander; Ramirez-Solis Ramiro; Krosl Jana; Grier David G; Lawrence H Jeffrey; Sauvageau Guy
Analysis of HSC activity and compensatory Hox gene expression profile in Hoxb cluster mutant fetal liver cells.
Blood 2006;108(1):116-22.
2006: Dhédin Nathalie; Chamakhi Inès; Perreault Claude; Roy Denis-Claude; Sauvageau Guy; Ducruet Thierry; Busque Lambert; Fish Douglas; Bélanger Robert; Roy Jean
Evidence that donor intrinsic response to G-CSF is the best predictor of acute graft-vs-host disease following allogeneic peripheral blood stem cell transplantation.
Experimental hematology 2006;34(1):107-14.
2005: Lawrence H Jeffrey; Christensen Julie; Fong Stephen; Hu Yu-Long; Weissman Irving; Sauvageau Guy; Humphries R Keith; Largman Corey
Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells.
Blood 2005;106(12):3988-94.
2005: Martin Nicole L; Saba-El-Leil Marc K; Sadekova Svetlana; Meloche Sylvain; Sauvageau Guy
EN2 is a candidate oncogene in human breast cancer.
Oncogene 2005;24(46):6890-901.
2005: Cellot Sonia; Sauvageau Guy
Gfi-1: another piece in the HSC puzzle.
Trends in immunology 2005;26(2):68-71.
2005: Bijl Janet; Sauvageau Martin; Thompson Alexander; Sauvageau Guy
High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.
Genes & development 2005;19(2):224-33.
2005: Iwasaki Masayuki; Kuwata Takeshi; Yamazaki Yukari; Jenkins Nancy A; Copeland Neal G; Osato Motomi; Ito Yoshiaki; Kroon Evert; Sauvageau Guy; Nakamura Takuro
Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model.
Blood 2005;105(2):784-93.
2004: Beslu Nathalie; Krosl Jana; Laurin Mélanie; Mayotte Nadine; Humphries Keith R; Sauvageau Guy
Molecular interactions involved in HOXB4-induced activation of HSC self-renewal.
Blood 2004;104(8):2307-14.
2004: Faubert Amélie; Lessard Julie; Sauvageau Guy
Are genetic determinants of asymmetric stem cell division active in hematopoietic stem cells?
Oncogene 2004;23(43):7247-55.
2004: Sauvageau Guy; Iscove Norman N; Humphries R Keith
In vitro and in vivo expansion of hematopoietic stem cells.
Oncogene 2004;23(43):7223-32.
2004: Lessard Julie; Faubert Amélie; Sauvageau Guy
Genetic programs regulating HSC specification, maintenance and expansion.
Oncogene 2004;23(43):7199-209.
2004: Krosl Jana K; Faubert Amelie; Sauvageau Guy
Molecular basis for stem-cell self-renewal.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5 Suppl 3():S118-21.
2003: Krosl Jana; Austin Pamela; Beslu Nathalie; Kroon Evert; Humphries R Keith; Sauvageau Guy
In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein.
Nature medicine 2003;9(11):1428-32.
2003: Lessard Julie; Sauvageau Guy
Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis.
Experimental hematology 2003;31(7):567-85.
2003: Lessard Julie; Sauvageau Guy
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Nature 2003;423(6937):255-60.
2003: Krosl Jana; Beslu Nathalie; Mayotte Nadine; Humphries R Keith; Sauvageau Guy
The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential.
Immunity 2003;18(4):561-71.
2002: Mayotte Nadine; Roy Denis-Claude; Yao Jing; Kroon Evert; Sauvageau Guy
Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system.
Blood 2002;100(12):4177-84.
2002: Buske Christian; Feuring-Buske Michaela; Abramovich Carolina; Spiekermann Karsten; Eaves Connie J; Coulombel Laure; Sauvageau Guy; Hogge Donna E; Humphries R Keith
Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells.
Blood 2002;100(3):862-8.
2002: Antonchuk Jennifer; Sauvageau Guy; Humphries R Keith
HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.
Cell 2002;109(1):39-45.
2002: Thorsteinsdottir Unnur; Mamo Aline; Kroon Evert; Jerome Lori; Bijl Janet; Lawrence H Jeffrey; Humphries Keith; Sauvageau Guy
Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion.
Blood 2002;99(1):121-9.
2001: Le Blanc R; Montminy-Métivier S; Bélanger R; Busque L; Fish D; Roy D C; Kassis J; Boileau J; Lavallée R; Bélanger D; Letendre F; Hébert J; Sauvageau G; Perreault C; Roy J
Allogeneic transplantation for multiple myeloma: further evidence for a GVHD-associated graft-versus-myeloma effect.
Bone marrow transplantation 2001;28(9):841-8.
2001: Antonchuk J; Sauvageau G; Humphries R K
HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation.
Experimental hematology 2001;29(9):1125-34.
2001: Kroon E; Thorsteinsdottir U; Mayotte N; Nakamura T; Sauvageau G
NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice.
The EMBO journal 2001;20(3):350-61.
2001: Thorsteinsdottir U; Kroon E; Jerome L; Blasi F; Sauvageau G
Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia.
Molecular and cellular biology 2001;21(1):224-34.
2000: Krosl J; Sauvageau G
AP-1 complex is effector of Hox-induced cellular proliferation and transformation.
Oncogene 2000;19(45):5134-41.
1999: Lessard J; Schumacher A; Thorsteinsdottir U; van Lohuizen M; Magnuson T; Sauvageau G
Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation.
Genes & development 1999;13(20):2691-703.
1999: Thorsteinsdottir U; Sauvageau G; Humphries R K
Enhanced in vivo regenerative potential of HOXB4-transduced hematopoietic stem cells with regulation of their pool size.
Blood 1999;94(8):2605-12.
1999: Thorsteinsdottir U; Krosl J; Kroon E; Haman A; Hoang T; Sauvageau G
The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells.
Molecular and cellular biology 1999;19(9):6355-66.
1998: Krosl J; Baban S; Krosl G; Rozenfeld S; Largman C; Sauvageau G
Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1.
Oncogene 1998;16(26):3403-12.
1998: Kroon E; Krosl J; Thorsteinsdottir U; Baban S; Buchberg A M; Sauvageau G
Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b.
The EMBO journal 1998;17(13):3714-25.
1998: Lessard J; Baban S; Sauvageau G
Stage-specific expression of polycomb group genes in human bone marrow cells.
Blood 1998;91(4):1216-24.
1997: Thorsteinsdottir U; Sauvageau G; Humphries R K
Hox homeobox genes as regulators of normal and leukemic hematopoiesis.
Hematology/oncology clinics of North America 1997;11(6):1221-37.
1997: Lawrence H J; Helgason C D; Sauvageau G; Fong S; Izon D J; Humphries R K; Largman C
Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.
Blood 1997;89(6):1922-30.
1997: Sauvageau G; Thorsteinsdottir U; Hough M R; Hugo P; Lawrence H J; Largman C; Humphries R K
Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation.
Immunity 1997;6(1):13-22.
1997: Thorsteinsdottir U; Sauvageau G; Hough M R; Dragowska W; Lansdorp P M; Lawrence H J; Largman C; Humphries R K
Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.
Molecular and cellular biology 1997;17(1):495-505.
1996: Lawrence H J; Sauvageau G; Humphries R K; Largman C
The role of HOX homeobox genes in normal and leukemic hematopoiesis.
Stem cells (Dayton, Ohio) 1996;14(3):281-91.
1996: Helgason C D; Sauvageau G; Lawrence H J; Largman C; Humphries R K
Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro.
Blood 1996;87(7):2740-9.
1996: Shen W F; Chang C P; Rozenfeld S; Sauvageau G; Humphries R K; Lu M; Lawrence H J; Cleary M L; Largman C
Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA.
Nucleic acids research 1996;24(5):898-906.
1996: Hough M R; Chappel M S; Sauvageau G; Takei F; Kay R; Humphries R K
Reduction of early B lymphocyte precursors in transgenic mice overexpressing the murine heat-stable antigen.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):479-88.
1995: Lawrence H J; Sauvageau G; Ahmadi N; Lopez A R; LeBeau M M; Link M; Humphries K; Largman C
Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells.
Experimental hematology 1995;23(11):1160-6.
1995: Sauvageau G; Thorsteinsdottir U; Eaves C J; Lawrence H J; Largman C; Lansdorp P M; Humphries R K
Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.
Genes & development 1995;9(14):1753-65.
1994: Sauvageau G; Lansdorp P M; Eaves C J; Hogge D E; Dragowska W H; Reid D S; Largman C; Lawrence H J; Humphries R K
Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12223-7.
1991: Routy J P; Beaulieu R; Monte M; Saint-Louis J; Sauvageau G; Toma E
Immunologic thrombocytopenia followed by thrombotic thrombocytopenic purpura in two HIV1 patients.
American journal of hematology 1991;38(4):327-8.
1990: Sauvageau G; Stocco R; Kasparian S; Menezes J
Epstein-Barr virus receptor expression on human CD8+ (cytotoxic/suppressor) T lymphocytes.
The Journal of general virology 1990;71 ( Pt 2)():379-86.
1990: Stocco R; Sauvageau G; Stefanescu I; Menezes J
Effect of monoclonal antibodies to Epstein-Barr virus envelope glycoproteins on Epstein-Barr virus neutralization and binding to target cell receptors. A comparative analysis.
Intervirology 1990;31(5):295-300.
1988: Stocco R; Sauvageau G; Menezes J
Differences in Epstein-Barr virus (EBV) receptors expression on various human lymphoid targets and their significance to EBV-cell interaction.
Virus research 1988;11(3):209-25.

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Guy Sauvageau

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