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Jun Shen

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All Publications

2013: Yan Zhang; Jun Shen
Soft constraints in nonlinear spectral fitting with regularized lineshape deconvolution.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2013;69(4):912-9.
2013: Jun Shen
Modeling the glutamate-glutamine neurotransmitter cycle.
Frontiers in neuroenergetics 2013;5():1.
2012: Jun Shen
Preserving the excitation profile of small flip angle RF pulses in the presence of rapid transverse relaxation.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2012;224():8-12.
2012: Giacomo Salvadore; Jun Shen; Jan Willem van der Veen; Jacqueline Baumann; Wayne C Drevets; Lobna A Ibrahim; David A Luckenbaugh; Rodrigo Machado-Vieira; Stefano Marenco; Yan Zhang; Carlos A Zarate
An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2012;15(8):1063-72.
2012: Shizhe Li; Maria Ferraris Araneta; Robert B Innis; Christopher Johnson; Yun Xiang; Yan Zhang; Jun Shen
In vivo detection of 13C isotopomer turnover in the human brain by sequential infusion of 13C labeled substrates.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2012;218():16-21.
2011: Yun Xiang; Jun Shen
In vivo detection of intermediate metabolic products of [1-(13) C]ethanol in the brain using (13) C MRS.
NMR in biomedicine 2011;24(9):1054-62.
2011: Matthew Geramita; Alan S Barnett; Antonina A Savostyanova; Jun Shen; Jan Willem van der Veen; Daniel R Weinberger; Stefano Marenco
Reproducibility of prefrontal γ-aminobutyric acid measurements with J-edited spectroscopy.
NMR in biomedicine 2011;24(9):1089-98.
2011: Jun Shen
Derivative encoding for parallel magnetic resonance imaging.
Medical physics 2011;38(10):5582-9.
2011: Yun Xiang; Jun Shen
Windowed stochastic proton decoupling for in vivo (13)C magnetic resonance spectroscopy with reduced RF power deposition.
Journal of magnetic resonance imaging : JMRI 2011;34(4):968-72.
2011: Yan Zhang; Shizhe Li; Stefano Marenco; Jun Shen
Quantitative measurement of N-acetyl-aspartyl-glutamate at 3 T using TE-averaged PRESS spectroscopy and regularized lineshape deconvolution.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2011;66(2):307-13.
2011: Yun Xiang; Jun Shen
Simultaneous detection of cerebral metabolism of different substrates by in vivo ¹³C isotopomer MRS.
Journal of neuroscience methods 2011;198(1):8-15.
2011: Busik Park; Martin J Lizak; Yun Xiang; Jun Shen
Slice with angulated non-parallel boundaries.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2011;210(1):98-106.
2010: Shizhe Li; Yan Zhang; Shumin Wang; Maria Ferraris Araneta; Christopher S Johnson; Yun Xiang; Robert B Innis; Jun Shen
13C MRS of occipital and frontal lobes at 3 T using a volume coil for stochastic proton decoupling.
NMR in biomedicine 2010;23(8):977-85.
2010: Jun Shen; Yun Xiang
High fidelity magnetic resonance imaging by frequency sweep encoding and Fourier decoding.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2010;204(2):200-7.
2009: Yan Zhang; Shizhe Li; Jun Shen
Automatic high-order shimming using parallel columns mapping (PACMAP).
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2009;62(4):1073-9.
2009: Jehoon Yang; Christopher Johnson; Jun Shen
Detection of reduced GABA synthesis following inhibition of GABA transaminase using in vivo magnetic resonance signal of [13C]GABA C1.
Journal of neuroscience methods 2009;182(2):236-43.
2009: Shizhe Li; Yan Zhang; Shumin Wang; Jehoon Yang; Maria Ferraris Araneta; Amanda Farris; Christopher Johnson; Stephen Fox; Robert Innis; Jun Shen
In vivo 13C magnetic resonance spectroscopy of human brain on a clinical 3 T scanner using [2-13C]glucose infusion and low-power stochastic decoupling.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2009;62(3):565-73.
2009: Jehoon Yang; Jun Shen
Elevated endogenous GABA concentration attenuates glutamate-glutamine cycling between neurons and astroglia.
Journal of neural transmission (Vienna, Austria : 1996) 2009;116(3):291-300.
2009: Gregor Hasler; Jan Willem van der Veen; Marilla Geraci; Jun Shen; Daniel Pine; Wayne C Drevets
Prefrontal cortical gamma-aminobutyric Acid levels in panic disorder determined by proton magnetic resonance spectroscopy.
Biological psychiatry 2009;65(3):273-5.
2009: Jun Shen; Douglas L Rothman; Kevin L Behar; Su Xu
Determination of the glutamate-glutamine cycling flux using two-compartment dynamic metabolic modeling is sensitive to astroglial dilution.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(1):108-18.
2008: Su Xu; Jehoon Yang; Jun Shen
Measuring N-acetylaspartate synthesis in vivo using proton magnetic resonance spectroscopy.
Journal of neuroscience methods 2008;172(1):8-12.
2008: Su Xu; Jehoon Yang; Jun Shen
Inverse polarization transfer for detecting in vivo 13C magnetization transfer effect of specific enzyme reactions in 1H spectra.
Magnetic resonance imaging 2008;26(3):413-9.
2008: Jehoon Yang; Sujata Singh; Jun Shen
13C saturation transfer effect of carbon dioxide-bicarbonate exchange catalyzed by carbonic anhydrase in vivo.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;59(3):492-8.
2007: Yan Zhang; Stefano Marenco; Jun Shen
Correction of frequency and phase variations induced by eddy currents in localized spectroscopy with multiple echo times.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2007;58(1):174-8.
2007: Gregor Hasler; Jan Willem van der Veen; Toni Tumonis; Noah Meyers; Jun Shen; Wayne C Drevets
Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy.
Archives of general psychiatry 2007;64(2):193-200.
2007: Shizhe Li; Jehoon Yang; Jun Shen
Novel strategy for cerebral 13C MRS using very low RF power for proton decoupling.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2007;57(2):265-71.
2007: Su Xu; Jehoon Yang; Jun Shen
In vivo 13C saturation transfer effect of the lactate dehydrogenase reaction.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2007;57(2):258-64.
2007: Jehoon Yang; Jun Shen
Relayed (13)C magnetization transfer: detection of malate dehydrogenase reaction in vivo.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2007;184(2):344-9.
2007: Jehoon Yang; Shizhe S Li; John Bacher; Jun Shen
Quantification of cortical GABA-glutamine cycling rate using in vivo magnetic resonance signal of [2-13C]GABA derived from glia-specific substrate [2-13C]acetate.
Neurochemistry international 2007;50(2):371-8.
2006: In-Young Choi; Sang-Pil Lee; Hellmut Merkle; Jun Shen
In vivo detection of gray and white matter differences in GABA concentration in the human brain.
NeuroImage 2006;33(1):85-93.
2006: Su Xu; Jun Shen
In vivo dynamic turnover of cerebral 13C isotopomers from [U-13C]glucose.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2006;182(2):221-8.
2006: Jehoon Yang; Jun Shen
Increased oxygen consumption in the somatosensory cortex of alpha-chloralose anesthetized rats during forepaw stimulation determined using MRS at 11.7 Tesla.
NeuroImage 2006;32(3):1317-25.
2006: Jun Shen
13C magnetic resonance spectroscopy studies of alterations in glutamate neurotransmission.
Biological psychiatry 2006;59(10):883-7.
2006: Jun Shen; Su Xu
Theoretical analysis of carbon-13 magnetization transfer for in vivo exchange between alpha-ketoglutarate and glutamate.
NMR in biomedicine 2006;19(2):248-54.
2006: Zhengguang Chen; Jun Shen
Single-shot echo-planar functional magnetic resonance imaging of representations of the fore- and hindpaws in the somatosensory cortex of rats using an 11.7 T microimager.
Journal of neuroscience methods 2006;151(2):268-75.
2005: Gregor Hasler; Alexander Neumeister; Jan Willem van der Veen; Toni Tumonis; Earle E Bain; Jun Shen; Wayne C Drevets; Dennis S Charney
Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy.
Biological psychiatry 2005;58(12):969-73.
2005: Shizhe Li; Zhengguang Chen; Yan Zhang; Martin Lizak; John Bacher; Robert B Innis; Jun Shen
In vivo single-shot, proton-localized 13C MRS of rhesus monkey brain.
NMR in biomedicine 2005;18(8):560-9.
2005: Jun Shen
In vivo carbon-13 magnetization transfer effect. Detection of aspartate aminotransferase reaction.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2005;54(6):1321-6.
2005: Su Xu; Jehoon Yang; Charles Q Li; Wenjun Zhu; Jun Shen
Metabolic alterations in focally activated primary somatosensory cortex of alpha-chloralose-anesthetized rats measured by 1H MRS at 11.7 T.
NeuroImage 2005;28(2):401-9.
2005: S Li; Jun Shen
Integrated RF probe for in vivo multinuclear spectroscopy and functional imaging of rat brain using an 11.7 Tesla 89 mm bore vertical microimager.
Magma (New York, N.Y.) 2005;18(3):119-27.
2005: Jehoon Yang; Charles Q Li; Jun Shen
In vivo detection of cortical GABA turnover from intravenously infused [1-13C]D-glucose.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2005;53(6):1258-67.
2005: In-Young Choi; Sang-Pil Lee; Jun Shen
Selective homonuclear Hartmann-Hahn transfer method for in vivo spectral editing in the human brain.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2005;53(3):503-10.
2005: Zhengguang Chen; Afonso C Silva; Jehoon Yang; Jun Shen
Elevated endogenous GABA level correlates with decreased fMRI signals in the rat brain during acute inhibition of GABA transaminase.
Journal of neuroscience research 2005;79(3):383-91.
2005: J Yang; Jun Shen
In vivo evidence for reduced cortical glutamate-glutamine cycling in rats treated with the antidepressant/antipanic drug phenelzine.
Neuroscience 2005;135(3):927-37.
2005: In-Young Choi; Sang-Pil Lee; Jun Shen
In vivo single-shot three-dimensionally localized multiple quantum spectroscopy of GABA in the human brain with improved spectral selectivity.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2005;172(1):9-16.
2004: Jun Shen; Jehoon Yang; In-Young Choi; Shizhe Steve Li; Zhengguang Chen
A new strategy for in vivo spectral editing. Application to GABA editing using selective homonuclear polarization transfer spectroscopy.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2004;170(2):290-8.
2004: Jun Shen; Zhengguang Chen; Jehoon Yang
New FOCI pulses with reduced radiofrequency power requirements.
Journal of magnetic resonance imaging : JMRI 2004;20(3):531-7.
2004: Zhengguang Chen; Shizhe Steve Li; Jehoon Yang; David Letizia; Jun Shen
Measurement and automatic correction of high-order B0 inhomogeneity in the rat brain at 11.7 Tesla.
Magnetic resonance imaging 2004;22(6):835-42.
2004: In-Young Choi; Sang-Pil Lee; Hellmut Merkle; Jun Shen
Single-shot two-echo technique for simultaneous measurement of GABA and creatine in the human brain in vivo.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;51(6):1115-21.
2003: Jun Shen
Slice-selective J-coupled coherence transfer using symmetric linear phase pulses: applications to localized GABA spectroscopy.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2003;163(1):73-80.
2002: Jun Shen; Douglas L Rothman
Magnetic resonance spectroscopic approaches to studying neuronal: glial interactions.
Biological psychiatry 2002;52(7):694-700.
2002: Vincent Lebon; Kitt Falk Petersen; Gary W Cline; Jun Shen; Graeme F Mason; Sylvie Dufour; Kevin L Behar; Gerald I Shulman; Douglas L Rothman
Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):1523-31.
2002: Jun Shen; Douglas L Rothman; Peter Brown
In vivo GABA editing using a novel doubly selective multiple quantum filter.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2002;47(3):447-54.
2001: Jun Shen
Effect of degenerate spherical harmonics and a method for automatic shimming of oblique slices.
NMR in biomedicine 2001;14(3):177-83.
2001: Jun Shen
Delayed-focus pulses optimized using simulated annealing.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2001;149(2):234-8.
2001: Nicola Sibson; Graeme F Mason; Jun Shen; Gary W Cline; A Z Herskovits; J E Wall; Kevin L Behar; Douglas L Rothman; Robert G Shulman
In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during.
Journal of neurochemistry 2001;76(4):975-89.
2000: Jullie W Pan; Daniel Stein; Frank Telang; Jing-Huei Lee; Jun Shen; P Brown; G Cline; Graeme F Mason; G I Shulman; D L Rothman; Hoby P Hetherington
Spectroscopic imaging of glutamate C4 turnover in human brain.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2000;44(5):673-9.
1999: Jun Shen; Douglas L Rothman; Hoby P Hetherington; Jullie W Pan
Linear projection method for automatic slice shimming.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1999;42(6):1082-8.
1999: Douglas L Rothman; Nicola Sibson; Fahmeed Hyder; Jun Shen; Kevin L Behar; Robert G Shulman
In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1387):1165-77.
1999: Gary W Cline; Kitt Falk Petersen; Martin Krssak; Jun Shen; Ripudaman S Hundal; Zlatko Trajanoski; Silvio E Inzucchi; A Dresner; Douglas L Rothman; Gerald I Shulman
Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes.
The New England journal of medicine 1999;341(4):240-6.
1999: Jun Shen; Kitt Falk Petersen; Kevin L Behar; P Brown; Terence W Nixon; Graeme F Mason; Ognen A C Petroff; G I Shulman; Robert G Shulman; Douglas L Rothman
Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8235-40.
1999: Jun Shen; Dikoma Shungu; Douglas L Rothman
In vivo chemical shift imaging of gamma-aminobutyric acid in the human brain.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1999;41(1):35-42.
1998: Jun Shen; Edward J Novotny; Douglas L Rothman
In vivo lactate and beta-hydroxybutyrate editing using a pure-phase refocusing pulse train.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1998;40(5):783-8.
1998: Jun Shen; Nicola Sibson; Gary W Cline; Kevin L Behar; Douglas L Rothman; Robert G Shulman
15N-NMR spectroscopy studies of ammonia transport and glutamine synthesis in the hyperammonemic rat brain.
Developmental neuroscience 1998;20(4-5):434-43.
1998: Nicola Sibson; Jun Shen; Graeme F Mason; Douglas L Rothman; Kevin L Behar; Robert G Shulman
Functional energy metabolism: in vivo 13C-NMR spectroscopy evidence for coupling of cerebral glucose consumption and glutamatergic neuronalactivity.
Developmental neuroscience 1998;20(4-5):321-30.
1997: Jun Shen; R E Rycyna; Douglas L Rothman
Improvements on an in vivo automatic shimming method [FASTERMAP].
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1997;38(5):834-9.
1997: Jun Shen; Douglas L Rothman
Fast automatic adjustment of on-axis shims for high-resolution NMR.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1997;127(2):229-32.
1997: Jun Shen; Douglas L Rothman
Adiabatic slice-selective excitation for surface coils.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1997;124(1):72-9.
1996: Jun Shen
Use of amplitude and frequency transformations to generate adiabatic pulses of wide bandwidth and low RF power deposition.
Journal of magnetic resonance. Series B 1996;112(2):131-40.
1995: Jun Shen; L E Lerner
A comparison of the conformation of sucrose octasulfate, free and bound to acidic fibroblast growth factor.
Carbohydrate research 1995;273(2):115-27.