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Russell Cox

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Asifa Munawar; James Marshall; Andrew M Bailey; Russell Cox; Colin M Lazarus
Isolation and characterisation of a ferrirhodin synthetase gene from the sugarcane pathogen Fusarium sacchari.
Katja Maria Fisch; Colin M Lazarus; Jennifer Pedrick; Thomas J Simpson; Zhongshu Song; Zahida Wasil; Ahmed A Yakasai; Andrew M Bailey; Walid Bakeer; Russell Cox
Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite.
Ahmed A Yakasai; Andrew M Bailey; Craig P Butts; Jack Davison; Laura M Halo; Colin M Lazarus; Thomas J Simpson; Zahida Wasil; Russell Cox
Nongenetic reprogramming of a fungal highly reducing polyketide synthase.

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All Publications

2013: Asifa Munawar; James Marshall; Andrew M Bailey; Russell Cox; Colin M Lazarus
Isolation and characterisation of a ferrirhodin synthetase gene from the sugarcane pathogen Fusarium sacchari.
Chembiochem : a European journal of chemical biology 2013;14(3):388-94.
2011: Katja Maria Fisch; Colin M Lazarus; Jennifer Pedrick; Thomas J Simpson; Zhongshu Song; Zahida Wasil; Ahmed A Yakasai; Andrew M Bailey; Walid Bakeer; Russell Cox
Rational domain swaps decipher programming in fungal highly reducing polyketide synthases and resurrect an extinct metabolite.
Journal of the American Chemical Society 2011;133(41):16635-41.
2011: Ahmed A Yakasai; Andrew M Bailey; Craig P Butts; Jack Davison; Laura M Halo; Colin M Lazarus; Thomas J Simpson; Zahida Wasil; Russell Cox
Nongenetic reprogramming of a fungal highly reducing polyketide synthase.
Journal of the American Chemical Society 2011;133(28):10990-8.
2011: Joanne Hothersall; Annabel C Murphy; Zafar Iqbal; Genevieve Campbell; Elton R Stephens; Ji'en Wu; Helen Cooper; Steve Atkinson; Paul Williams; John Crosby; Christine L Willis; Russell Cox; Thomas J Simpson; Christopher M Thomas
Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production.
Applied microbiology and biotechnology 2011;90(3):1017-26.
2011: Annabel C Murphy; Daisuke Fukuda; Zhongshu Song; Joanne Hothersall; Russell Cox; Christine L Willis; Christopher M Thomas; Thomas J Simpson
Engineered thiomarinol antibiotics active against MRSA are generated by mutagenesis and mutasynthesis of Pseudoalteromonas SANK73390.
Angewandte Chemie (International ed. in English) 2011;50(14):3271-4.
2011: Daisuke Fukuda; Anthony S Haines; Zhongshu Song; Annabel C Murphy; Joanne Hothersall; Elton R Stephens; Rachel Gurney; Russell Cox; John Crosby; Christine L Willis; Thomas J Simpson; Christopher M Thomas
A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic.
PloS one 2011;6(3):e18031.
2010: Katja Maria Fisch; Elizabeth Skellam; David Ivison; Russell Cox; Andrew M Bailey; Colin M Lazarus; Thomas J Simpson
Catalytic role of the C-terminal domains of a fungal non-reducing polyketide synthase.
Chemical communications (Cambridge, England) 2010;46(29):5331-3.
2010: Mary N Heneghan; Ahmed A Yakasai; Laura M Halo; Zhongshu Song; Andrew M Bailey; Thomas J Simpson; Russell Cox; Colin M Lazarus
First heterologous reconstruction of a complete functional fungal biosynthetic multigene cluster.
Chembiochem : a European journal of chemical biology 2010;11(11):1508-12.
2010: Elizabeth J Skellam; Deirdre Hurley; Jack Davison; Colin M Lazarus; Thomas J Simpson; Russell Cox
Mutation of key residues in the C-methyltransferase domain of a fungal highly reducing polyketide synthase.
Molecular bioSystems 2010;6(4):680-2.
2010: Pakorn Wattana-amorn; Christopher Williams; Eliza Płoskoń; Russell Cox; Thomas J Simpson; John Crosby; Matthew Crump
Solution structure of an acyl carrier protein domain from a fungal type I polyketide synthase.
Biochemistry 2010;49(10):2186-93.
2009: Simon E Evans; Christopher Williams; Christopher Arthur; Eliza Płoskoń; Pakorn Wattana-amorn; Russell Cox; John Crosby; Christine L Willis; Thomas J Simpson; Matthew Crump
Probing the Interactions of early polyketide intermediates with the Actinorhodin ACP from S. coelicolor A3(2).
Journal of molecular biology 2009;389(3):511-28.
2009: Pedro Beltran-Alvarez; Christopher Arthur; Russell Cox; John Crosby; Matthew Crump; Thomas J Simpson
Preliminary kinetic analysis of acyl carrier protein-ketoacylsynthase interactions in the actinorhodin minimal polyketide synthase.
Molecular bioSystems 2009;5(5):511-8.
2009: Russell Cox; Thomas J Simpson
Fungal type I polyketide synthases.
Methods in enzymology 2009;459():49-78.
2008: Laura M Halo; Mary N Heneghan; Ahmed A Yakasai; Zhongshu Song; Katherine Williams; Andrew M Bailey; Russell Cox; Colin M Lazarus; Thomas J Simpson
Late stage oxidations during the biosynthesis of the 2-pyridone tenellin in the entomopathogenic fungus Beauveria bassiana.
Journal of the American Chemical Society 2008;130(52):17988-96.
2008: Ji'en Wu; Joanne Hothersall; Carlo Mazzetti; Yvonne O'Connell; Jennifer A Shields; Ayesha S Rahman; Russell Cox; John Crosby; Thomas J Simpson; Christopher M Thomas; Christine L Willis
In vivo mutational analysis of the mupirocin gene cluster reveals labile points in the biosynthetic pathway: the "leaky hosepipe" mechanism.
Chembiochem : a European journal of chemical biology 2008;9(9):1500-8.
2008: Laura M Halo; James Marshall; Ahmed A Yakasai; Zhongshu Song; Craig P Butts; Matthew Crump; Mary Heneghan; Andrew M Bailey; Thomas J Simpson; Colin M Lazarus; Russell Cox
Authentic heterologous expression of the tenellin iterative polyketide synthase nonribosomal peptide synthetase requires coexpression with an enoyl reductase.
Chembiochem : a European journal of chemical biology 2008;9(4):585-94.
2007: Pedro Beltran-Alvarez; Russell Cox; John Crosby; Thomas J Simpson
Dissecting the component reactions catalyzed by the actinorhodin minimal polyketide synthase.
Biochemistry 2007;46(50):14672-81.
2007: Andrew M Bailey; Russell Cox; Kate Harley; Colin M Lazarus; Thomas J Simpson; Elizabeth Skellam
Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis.
Chemical communications (Cambridge, England) 2007;(39):4053-5.
2007: Russell Cox
Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets.
Organic & biomolecular chemistry 2007;5(13):2010-26.
2007: Ji'en Wu; Sian M Cooper; Russell Cox; John Crosby; Matthew Crump; Joanne Hothersall; Thomas J Simpson; Christopher M Thomas; Christine L Willis
Mupirocin H, a novel metabolite resulting from mutation of the HMG-CoA synthase analogue, mupH in Pseudomonas fluorescens.
Chemical communications (Cambridge, England) 2007;(20):2040-2.
2007: Joanne Hothersall; Ji'en Wu; Ayesha S Rahman; Jennifer A Shields; James Haddock; Nicola Johnson; Sian M Cooper; Elton R Stephens; Russell Cox; John Crosby; Christine L Willis; Thomas J Simpson; Christopher M Thomas
Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by pseudomonas fluorescens: pseudomonic acid B biosynthesis precedes pseudomonic acid A.
The Journal of biological chemistry 2007;282(21):15451-61.
2007: Ioannis Eleftherianos; Sam Boundy; Susan A Joyce; Shazia Aslam; James Marshall; Russell Cox; Thomas J Simpson; David J Clarke; Richard H ffrench-Constant; Stuart E Reynolds
An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2419-24.
2007: Kirstin L Eley; Laura M Halo; Zhongshu Song; Henry Powles; Russell Cox; Andrew M Bailey; Colin M Lazarus; Thomas J Simpson
Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana.
Chembiochem : a European journal of chemical biology 2007;8(3):289-97.
2007: Russell Cox; Andrew S Evitt
Acyl palladium species in synthesis: single-step synthesis of alpha,beta-unsaturated ketones from acid chlorides.
Organic & biomolecular chemistry 2007;5(2):229-32.
2007: David O Rees; Nick Bushby; Russell Cox; John R Harding; Thomas J Simpson; Christine L Willis
Synthesis of [1,2-13C2, 15N]-L-homoserine and its incorporation by the PKS-NRPS system of Fusarium moniliforme into the mycotoxin fusarin C.
Chembiochem : a European journal of chemical biology 2007;8(1):46-50.
2007: Ursula Wong; Russell Cox
The chemical mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase from Escherichia coli.
Angewandte Chemie (International ed. in English) 2007;46(26):4926-9.
2006: Yue Ma; Leah H Smith; Russell Cox; Pedro Beltran-Alvarez; Christopher Arthur; Thomas J Simpson F R S
Catalytic relationships between type I and type II iterative polyketide synthases: The Aspergillus parasiticus norsolorinic acid synthase.
Chembiochem : a European journal of chemical biology 2006;7(12):1951-8.
2006: Christopher Arthur; Anna E Szafranska; Jed Long; Jane Mills; Russell Cox; Stuart C Findlow; Thomas J Simpson; Matthew Crump; John Crosby
The malonyl transferase activity of type II polyketide synthase acyl carrier proteins.
Chemistry & biology 2006;13(6):587-96.
2005: Russell Cox; Jennifer S Gibson; Andrea T Hadfield
Design, synthesis and analysis of inhibitors of bacterial aspartate semialdehyde dehydrogenase.
Chembiochem : a European journal of chemical biology 2005;6(12):2255-60.
2005: Ludovic Mercklé; Ana de Andrés-Gómez; Bethany Dick; Russell Cox; Christopher R A Godfrey
A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Chembiochem : a European journal of chemical biology 2005;6(10):1866-74.
2005: Sian M Cooper; Wanpen Laosripaiboon; Ayesha S Rahman; Joanne Hothersall; A Kassem El-Sayed; Christopher J Winfield; John Crosby; Russell Cox; Thomas J Simpson; Christopher M Thomas
Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.
Chemistry & biology 2005;12(7):825-33.
2005: Sian M Cooper; Russell Cox; John Crosby; Matthew Crump; Joanne Hothersall; Wanpen Laosripaiboon; Thomas J Simpson; Christopher M Thomas
Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster.
Chemical communications (Cambridge, England) 2005;(9):1179-81.
2005: Russell Cox; Dougal J Ritson; Thomas A Dane; John Berge; Jonathan P H Charmant; Anob Kantacha
Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes.
Chemical communications (Cambridge, England) 2005;(8):1037-9.
2004: Russell Cox; Frank Glod; Deirdre Hurley; Colin M Lazarus; Thomas P Nicholson; Brian A M Rudd; Thomas J Simpson; Barrie Wilkinson; Ying Zhang
Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis.
Chemical communications (Cambridge, England) 2004;(20):2260-1.
2004: Zhongshu Song; Russell Cox; Colin M Lazarus; Thomas J Simpson TJ
Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum.
Chembiochem : a European journal of chemical biology 2004;5(9):1196-1203.
2004: Dougal J Ritson; Russell Cox; John Berge
Indium mediated allylation of glyoxylate oxime ethers, esters and cyanoformates.
Organic & biomolecular chemistry 2004;2(13):1921-33.
2004: Watchrra Teartasin; Claire Limpkin; Frank Glod; James Spencer; Russell Cox; Thomas J Simpson; John Crosby; Matthew Crump; Andrea T Hadfield
Expression, purification and preliminary X-ray diffraction analysis of a ketoreductase from a type II polyketide synthase.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 6):1137-8.
2004: Luke A Adams; Jonathan P H Charmant; Russell Cox; Magnus Walter; William G Whittingham
Efficient synthesis of protected cyclopropyl beta-aspartylphosphates.
Organic & biomolecular chemistry 2004;2(4):542-53.
2003: Luke A Adams; Varinder K Aggarwal; Roger V Bonnert; Bettina Bressel; Russell Cox; Jon Shepherd; Javier de Vicente; Magnus Walter; William G Whittingham; Caroline L Winn
Diastereoselective synthesis of cyclopropane amino acids using diazo compounds generated in situ.
The Journal of organic chemistry 2003;68(24):9433-40.
2003: Russell Cox; Ana de Andrés-Gómez; Christopher R A Godfrey
Rapid and flexible synthesis of 1-deoxy-D-xylulose-5-phosphate, the substrate for 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Organic & biomolecular chemistry 2003;1(18):3173-7.
2003: Thomas P Nicholson; Christopher J Winfield; James Westcott; John Crosby; Thomas J Simpson; Russell Cox
First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determination.
Chemical communications (Cambridge, England) 2003;(6):686-7.
2003: Michelle A Reed; Michael Schweizer; Anna E Szafranska; Christopher Arthur; Thomas P Nicholson; Russell Cox; John Crosby; Matthew Crump; Thomas J Simpson
The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs.
Organic & biomolecular chemistry 2003;1(3):463-71.
2002: Luke A Adams; Russell Cox; Jennifer S Gibson; María Belén Mayo Martín; Magnus Walter; William G Whittingham
A new synthesis of phosphoramidates: inhibitors of the key bacterial enzyme aspartate semi-aldehyde dehydrogenase.
Chemical communications (Cambridge, England) 2002;(18):2004-5.
2002: Russell Cox; Jennifer S Gibson; María Belén Mayo Martín
Aspartyl phosphonates and phosphoramidates: the first synthetic inhibitors of bacterial aspartate-semialdehyde dehydrogenase.
Chembiochem : a European journal of chemical biology 2002;3(9):874-86.
2002: Christopher Arthur; Russell Cox; John Crosby; Mujiber M Rahman; Thomas J Simpson; Florilene Soulas; Roberto Spogli; Anna E Szafranska; James Westcott; Christopher J Winfield
Synthesis and characterisation of acyl carrier protein bound polyketide analogues.
Chembiochem : a European journal of chemical biology 2002;3(2-3):253-7.
2002: Anna E Szafranska; Timothy S Hitchman; Russell Cox; John Crosby; Thomas J Simpson
Kinetic and mechanistic analysis of the malonyl CoA:ACP transacylase from Streptomyces coelicolor indicates a single catalytically competent serine nucleophile at the active site.
Biochemistry 2002;41(5):1421-7.
2001: Russell Cox; Andrea T Hadfield; María Belén Mayo Martín
Difluoromethylene analogues of aspartyl phosphate: the first synthetic inhibitors of aspartate semi-aldehyde dehydrogenase.
Chemical communications (Cambridge, England) 2001;(18):1710-1.
2001: Thomas P Nicholson; Brian A M Rudd; M Dawson; Colin M Lazarus; Thomas J Simpson; Russell Cox
Design and utility of oligonucleotide gene probes for fungal polyketide synthases.
Chemistry & biology 2001;8(2):157-78.
2000: Russell Cox; Andrew Sutherland; John C Vederas
Bacterial diaminopimelate metabolism as a target for antibiotic design.
Bioorganic & medicinal chemistry 2000;8(5):843-71.
1999: Christian P Bisang; Paul F Long; Jesús Cortés; James Westcott; John Crosby; Anne-Lise Matharu; Russell Cox; Thomas J Simpson; James Staunton; Peter F Leadlay
A chain initiation factor common to both modular and aromatic polyketide synthases.
Nature 1999;401(6752):502-5.
1998: Anne-Lise Matharu; Russell Cox; John Crosby; KJ Byrom; Thomas J Simpson
MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor.
Chemistry & biology 1998;5(12):699-711.
1998: John Crosby; KJ Byrom; Timothy S Hitchman; Russell Cox; Matthew Crump; I S Findlow; M J Bibb; Thomas J Simpson
Acylation of Streptomyces type II polyketide synthase acyl carrier proteins.
FEBS letters 1998;433(1-2):132-8.
1998: Russell Cox; J A Schouten; R A Stentiford; K J Wareing
Peptide inhibitors of N-succinyl diaminopimelic acid aminotransferase (DAP-AT): a novel class of antimicrobial compounds.
Bioorganic & medicinal chemistry letters 1998;8(8):945-50.
1998: Timothy S Hitchman; John Crosby; KJ Byrom; Russell Cox; Thomas J Simpson
Catalytic self-acylation of type II polyketide synthase acyl carrier proteins.
Chemistry & biology 1998;5(1):35-47.
1997: Russell Cox; Timothy S Hitchman; KJ Byrom; I S Findlow; Julian Tanner; John Crosby; Thomas J Simpson
Post-translational modification of heterologously expressed Streptomyces type II polyketide synthase acyl carrier proteins.
FEBS letters 1997;405(3):267-72.
1996: Russell Cox
The DAP pathway to lysine as a target for antimicrobial agents.
Natural product reports 1996;13(1):29-43.