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Russell Lingham

Research Profile

Chemicals & Drugs

Living Beings

Rats
HIV-1

Genes & Molecular Sequences

Molecular Structure

Concepts & Ideas

Physiology

Fermentation

Phenomena

Magnetic Resonance Spectroscopy

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Publications

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Thomas S Reger; Jasmine Zunic; Nicholas Stock; Bowei Wang; Nicholas D Smith; Benito Munoz; Mitchell D Green; Michael F Gardner; Joyce P James; Weichao Chen; Kenneth Alves; Qian Si; Kelly M Treonze; Russell Lingham; Richard A Mumford
Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists.
Shankar Venkatraman; Alec D Lebsack; Kenneth Alves; Michael F Gardner; Joyce James; Russell Lingham; Salony Maniar; Richard A Mumford; Qian Si; Nicholas Stock; Kelly M Treonze; Bowei Wang; Jasmine Zunic; Benito Munoz
Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
Kelly M Treonze; Kenneth Alves; Paul Fischer; William K Hagmann; Donald Hora; Alison Kulick; Ken Vakerich; Nicholas D Smith; Russell Lingham; Salony Maniar; Thomas S Reger; Jasmine Zunic; Benito Munoz; Peppi Prasit; Donald Nicholson; Qian Si; Keith Judd; Susan Nicolich; Patricia Kellerhouse; Donald Thompson; Richard A Mumford
Characterization of alpha(4)beta(1) (CD49d/CD29) on equine leukocytes: potential utility of a potent alpha(4)beta(1) (CD49d/CD29) receptor antagonist in the treatment of equine heaves (recurrent airway obstruction).

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All Publications

2010: Thomas S Reger; Jasmine Zunic; Nicholas Stock; Bowei Wang; Nicholas D Smith; Benito Munoz; Mitchell D Green; Michael F Gardner; Joyce P James; Weichao Chen; Kenneth Alves; Qian Si; Kelly M Treonze; Russell Lingham; Richard A Mumford
Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2010;20(3):1173-6.
2009: Shankar Venkatraman; Alec D Lebsack; Kenneth Alves; Michael F Gardner; Joyce James; Russell Lingham; Salony Maniar; Richard A Mumford; Qian Si; Nicholas Stock; Kelly M Treonze; Bowei Wang; Jasmine Zunic; Benito Munoz
Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
Bioorganic & medicinal chemistry letters 2009;19(19):5803-6.
2009: Kelly M Treonze; Kenneth Alves; Paul Fischer; William K Hagmann; Donald Hora; Alison Kulick; Ken Vakerich; Nicholas D Smith; Russell Lingham; Salony Maniar; Thomas S Reger; Jasmine Zunic; Benito Munoz; Peppi Prasit; Donald Nicholson; Qian Si; Keith Judd; Susan Nicolich; Patricia Kellerhouse; Donald Thompson; Richard A Mumford
Characterization of alpha(4)beta(1) (CD49d/CD29) on equine leukocytes: potential utility of a potent alpha(4)beta(1) (CD49d/CD29) receptor antagonist in the treatment of equine heaves (recurrent airway obstruction).
Veterinary immunology and immunopathology 2009;130(1-2):79-87.
2005: Shankar Venkatraman; Jongwon Lim; Merryl Cramer; Michael F Gardner; Joyce James; Kenneth Alves; Russell Lingham; Richard A Mumford; Benito Munoz
Influence of acid surrogates toward potency of VLA-4 antagonist.
Bioorganic & medicinal chemistry letters 2005;15(18):4053-6.
2005: Hiranthi Jayasuriya; Deborah L Zink; Jon D Polishook; Gerald F Bills; Anne W Dombrowski; Olga Genilloud; Fernando Pelaez; Lucia Herranz; Donette Quamina; Russell Lingham; Renee Danzeizen; Pia L Graham; Joanne E Tomassini; Sheo B Singh
Identification of diverse microbial metabolites as potent inhibitors of HIV-1 Tat transactivation.
Chemistry & biodiversity 2005;2(1):112-22.
2004: Sheo B Singh; John G Ondeyka; Nasios Tsipouras; Carolyn Ruby; Vinod Sardana; Marvin Schulman; Manuel Sanchez; Fernando Pelaez; Mark Stahlhut; Sanjeev Munshi; David B Olsen; Russell Lingham
Hinnuliquinone, a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease.
Biochemical and biophysical research communications 2004;324(1):108-13.
2003: Sheo B Singh; Deborah L Zink; Gerald F Bills; Ana Teran; Keith C Silverman; Russell Lingham; Peter J Felock; Daria J Hazuda
Four novel bis-(naphtho-gamma-pyrones) isolated from Fusarium species as inhibitors of HIV-1 integrase.
Bioorganic & medicinal chemistry letters 2003;13(4):713-7.
2002: Hiranthi Jayasuriya; Russell Lingham; Pia Graham; Donette Quamina; Lucia Herranz; Olga Genilloud; Magda Gagliardi; Renee Danzeisen; Joanne E Tomassini; Deborah L Zink; Ziqiang Guan; Sheo B Singh
Durhamycin A, a potent inhibitor of HIV Tat transactivation.
Journal of natural products 2002;65(8):1091-5.
2002: Linda A Egger; Usha Kidambi; Jin Cao; Gail Van Riper; Ermengilda McCauley; Richard A Mumford; Suzanne E Amo; Russell Lingham; Thomas J Lanza; Linus S Lin; Stephen E de Laszlo; David N Young; Ihor E Kopka; Sharon Tong; Bill Pikounis; Evelyn Benson; Sarah Warwood; Robert Bargatze; William K Hagmann; John A Schmidt; Patricia A Detmers
Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow.
The Journal of pharmacology and experimental therapeutics 2002;302(1):153-62.
2002: R Blake Pepinsky; Richard A Mumford; Ling Ling Chen; Diane R Leone; Suzanne E Amo; Gail Van Riper; Adrian Whitty; Brian M Dolinski; Roy R Lobb; Dennis C Dean; Linda L Chang; Conrad E Raab; Qian Si; William K Hagmann; Russell Lingham
Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1.
Biochemistry 2002;41(22):7125-41.
2002: Sheo B Singh; Kithsiri B Herath; Ziqiang Guan; Deborah L Zink; Anne W Dombrowski; Jon D Polishook; Keith C Silverman; Russell Lingham; Peter J Felock; Daria J Hazuda
Integramides A and B, two novel non-ribosomal linear peptides containing nine C(alpha)-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase.
Organic letters 2002;4(9):1431-4.
2002: Sheo B Singh; Deborah L Zink; Brian Heimbach; Olga Genilloud; Ana Teran; Keith C Silverman; Russell Lingham; Peter J Felock; Daria J Hazuda
Structure, stereochemistry, and biological activity of integramycin, a novel hexacyclic natural product produced by Actinoplanes sp. that inhibits HIV-1 integrase.
Organic letters 2002;4(7):1123-6.
2002: Sheo B Singh; Russell Lingham
Current progress on farnesyl protein transferase inhibitors.
Current opinion in drug discovery & development 2002;5(2):225-44.
2001: Sheo B Singh; Hiranthi Jayasuriya; Gino M Salituro; Deborah L Zink; A Shafiee; B Heimbuch; Keith C Silverman; Russell Lingham; Olga Genilloud; Ana Teran; D Vilella; Peter J Felock; Daria J Hazuda
The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.
Journal of natural products 2001;64(7):874-82.
2000: A Fowler; M Price-Jones; K Hughes; J Anson; Russell Lingham; M Schulman
Development of a high throughput scintillation proximity assay for hepatitis C virus NS3 protease that reduces the proportion of competitive inhibitors identified.
Journal of biomolecular screening 2000;5(3):153-8.
2000: Sheo B Singh; Hiranthi Jayasuriya; Keith C Silverman; Cynthia Bonfiglio; Joanne M Williamson; Russell Lingham
Efficient syntheses, human and yeast farnesyl-protein transferase inhibitory activities of chaetomellic acids and analogues.
Bioorganic & medicinal chemistry 2000;8(3):571-80.
1999: A Zhao; S H Lee; Marina Mojena; Rosalind G Jenkins; D R Patrick; H E Huber; Michael A Goetz; OD Hensens; Deborah L Zink; D Vilella; Anne W Dombrowski; Russell Lingham; L Huang
Resorcylic acid lactones: naturally occurring potent and selective inhibitors of MEK.
The Journal of antibiotics 1999;52(12):1086-94.
1999: Daria J Hazuda; CU Blau; Peter J Felock; J Hastings; B Pramanik; Abigail Wolfe; Frederic D Bushman; Chris Farnet; M Goetz; M Williams; Keith C Silverman; Russell Lingham; S Singh
Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolites.
Antiviral chemistry & chemotherapy 1999;10(2):63-70.
1998: Hiranthi Jayasuriya; Keith C Silverman; Deborah L Zink; Rosalind G Jenkins; Manuel Sanchez; Fernando Pelaez; D Vilella; Russell Lingham; Sheo B Singh
Clavaric acid: a triterpenoid inhibitor of farnesyl-protein transferase from Clavariadelphus truncatus.
Journal of natural products 1998;61(12):1568-70.
1998: Russell Lingham; Keith C Silverman; Hiranthi Jayasuriya; B M Kim; Suzanne E Amo; F R Wilson; D J Rew; Michael D Schaber; James Bergstrom; Kenneth S Koblan; Samuel L Graham; Nancy E Kohl; Jackson B Gibbs; Sheo B Singh
Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase.
Journal of medicinal chemistry 1998;41(23):4492-501.
1998: Sheo B Singh; Deborah L Zink; M Williams; Jon D Polishook; Manuel Sanchez; Keith C Silverman; Russell Lingham
Kampanols: novel Ras farnesyl-protein transferase inhibitors from Stachybotrys kampalensis.
Bioorganic & medicinal chemistry letters 1998;8(16):2071-6.
1997: Keith C Silverman; Hiranthi Jayasuriya; C Cascales; D Vilella; Gerald F Bills; Rosalind G Jenkins; Sheo B Singh; Russell Lingham
Oreganic acid, a potent inhibitor of ras farnesyl-protein transferase.
Biochemical and biophysical research communications 1997;232(2):478-81.
1996: Joanne E Tomassini; Mary-Ellen Davies; J C Hastings; Russell Lingham; M Mojena; S L Raghoobar; Sheo B Singh; J S Tkacz; Michael A Goetz
A novel antiviral agent which inhibits the endonuclease of influenza viruses.
Antimicrobial agents and chemotherapy 1996;40(5):1189-93.
1996: Russell Lingham; A H Hsu; J A O'Brien; J M Sigmund; Manuel Sanchez; M M Gagliardi; B K Heimbuch; Olga Genilloud; I Martin; M T Diez; C F Hirsch; Deborah L Zink; J M Liesch; G E Koch; Suzanne Gartner; George M Garrity; N N Tsou; G M Salituro
Quinoxapeptins: novel chromodepsipeptide inhibitors of HIV-1 and HIV-2 reverse transcriptase. I. The producing organism and biological activity.
The Journal of antibiotics 1996;49(3):253-9.
1995: Hiranthi Jayasuriya; R G Ball; Deborah L Zink; J L Smith; Michael A Goetz; Rosalind G Jenkins; M Nallin-Omstead; Keith C Silverman; Gerald F Bills; Russell Lingham
Barceloneic acid A, a new farnesyl-protein transferase inhibitor from a Phoma species.
Journal of natural products 1995;58(7):986-91.
1993: Russell Lingham; Keith C Silverman; Gerald F Bills; C Cascales; Manuel Sanchez; Rosalind G Jenkins; Suzanne Gartner; I Martin; M T Diez; F Peláez
Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase.
Applied microbiology and biotechnology 1993;40(2-3):370-4.
1993: T S Chen; G A Doss; A Hsu; A Hsu; Russell Lingham; R F White; R L Monaghan
Microbial transformation of L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease.
Journal of natural products 1993;56(5):755-61.
1993: Jackson B Gibbs; DL Pompliano; Scott D Mosser; Elaine Rands; Russell Lingham; Sheo B Singh; E M Scolnick; Nancy E Kohl; Allen Oliff
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.
The Journal of biological chemistry 1993;268(11):7617-20.
1992: Russell Lingham; A Hsu; Keith C Silverman; Gerald F Bills; A Dombrowski; M E Goldman; Paul L Darke; L Huang; G Koch; J G Ondeyka
L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. III. Biological activity.
The Journal of antibiotics 1992;45(5):686-91.
1992: J Ondeyka; O D Hensens; Deborah L Zink; R Ball; Russell Lingham; Gerald F Bills; A Dombrowski; M Goetz
L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. II. Isolation and structure.
The Journal of antibiotics 1992;45(5):679-85.
1992: A W Dombrowski; Gerald F Bills; G Sabnis; L R Koupal; R Meyer; J G Ondeyka; R A Giacobbe; R L Monaghan; Russell Lingham
L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. I. The producing organism and its fermentation.
The Journal of antibiotics 1992;45(5):671-8.
1991: Russell Lingham; Byron H Arison; L F Colwell; A Hsu; G Dezeny; W J Thompson; George M Garrity; M M Gagliardi; F W Hartner; Paul L Darke
HIV-1 protease inhibitory activity of L-694,746, a novel metabolite of L-689,502.
Biochemical and biophysical research communications 1991;181(3):1456-61.
1990: George M Stancel; C Chiapetta; R M Gardner; J L Kirkland; T H Lin; Russell Lingham; D S Loose-Mitchell; V R Mukku; C A Orengo
Regulation of the uterine epidermal growth factor receptor by estrogen.
Progress in clinical and biological research 1990;322():213-26.
1989: Zehava Gottesfeld; C J Garcia; Russell Lingham; R B Chronister
Prenatal ethanol exposure impairs lesion-induced plasticity in a dopaminergic synapse after maturity.
Neuroscience 1989;29(3):715-23.
1988: Russell Lingham; George M Stancel; D S Loose-Mitchell
Estrogen regulation of epidermal growth factor receptor messenger ribonucleic acid.
Molecular endocrinology (Baltimore, Md.) 1988;2(3):230-5.
1987: R M Gardner; Russell Lingham; George M Stancel
Contractions of the isolated uterus stimulated by epidermal growth factor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1987;1(3):224-8.
1987: George M Stancel; R M Gardner; J L Kirkland; T H Lin; Russell Lingham; D S Loose-Mitchell; V R Mukku; C A Orengo; G Verner
Interactions between estrogen and EGF in uterine growth and function.
Advances in experimental medicine and biology 1987;230():99-118.
1986: Russell Lingham; Zehava Gottesfeld
Deafferentation elicits increased dopamine-sensitive adenylate cyclase and receptor binding in the olfactory tubercle.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1986;6(8):2208-14.
1986: Russell Lingham; P J Brown; V Holcombe; C L Schreiber
Monoclonal antibodies to the guanine-nucleotide binding proteins of adenylate cyclase.
The Biochemical journal 1986;236(1):267-71.
1982: Russell Lingham; A K Sen
Regulation of rat brain (Na+ +K+)-ATPase activity by cyclic AMP.
Biochimica et biophysica acta 1982;688(2):475-85.
1980: Russell Lingham; D J Stewart; A K Sen
The induction of (Na+ + K+)-ATPase in the salt gland of the duck.
Biochimica et biophysica acta 1980;601(1):229-34.