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Chung (David) K. Chu

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TOP 3
Ravindra K Rawal; Uma Sharan Singh; Srinivas Gadthula; Chung (David) K. Chu
Synthesis of entecavir and its novel class of analogs.
Jianing Wang; Jakyung Yoo; Massaya Sugiyama; Rajgopal Govindarajan; Zhuhui Huang; Ashok K Jha; Brent Korba; Michael G Murray; Ravindra K Rawal; Melissa Scroggin; Uma S Singh; Masaya Sugiyama; Yasuhito Tanaka; Chung (David) K. Chu
Antiviral activity of novel 2'-fluoro-6'-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants.
Julia Friedman; Nancie M Archin; Won-Kyung Cho; Chung (David) K. Chu; Kara S Keedy; David M Margolis; Jonathan Karn
Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2.

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All Publications

2011: Ravindra K Rawal; Uma Sharan Singh; Srinivas Gadthula; Chung (David) K. Chu
Synthesis of entecavir and its novel class of analogs.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2011;Chapter 14():Unit 14.7.1-17.
2011: Jianing Wang; Jakyung Yoo; Massaya Sugiyama; Rajgopal Govindarajan; Zhuhui Huang; Ashok K Jha; Brent Korba; Michael G Murray; Ravindra K Rawal; Melissa Scroggin; Uma S Singh; Masaya Sugiyama; Yasuhito Tanaka; Chung (David) K. Chu
Antiviral activity of novel 2'-fluoro-6'-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants.
Bioorganic & medicinal chemistry letters 2011;21(21):6328-31.
2011: Julia Friedman; Nancie M Archin; Won-Kyung Cho; Chung (David) K. Chu; Kara S Keedy; David M Margolis; Jonathan Karn
Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2.
Journal of virology 2011;85(17):9078-89.
2011: Srinivas Gadthula; Brent Korba; Ravindra K Rawal; Ashoke Sharon; Dong Wu; Chung (David) K. Chu
Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6-diol against hepatitis C virus.
Bioorganic & medicinal chemistry letters 2011;21(13):3982-5.
2010: Omar N Al Safarjalani; Reem H Rais; Young Ah Kim; Chung (David) K. Chu; Fardos N M Naguib; Mahmoud el Kouni
Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: biological activities and selective toxicities.
Biochemical pharmacology 2010;80(7):955-63.
2010: Adèle Hannigan; Paul Smith; Gabriela Kalna; Cristiana Lo Nigro; Clare Orange; Darren I O'Brien; Reshma Shah; Nelofer Syed; Lindsay C Spender; Blanca Herrera; Johanna K Thurlow; Laura Lattanzio; Martino Monteverde; Meghan E Maurer; Francesca M Buffa; Jelena Mann; Chung (David) K. Chu; Catharine M L West; Max Patridge; Karin A Oien; Jonathan A Cooper; Margaret C Frame; Adrian L Harris; Louise Hiller; Linda J Nicholson; Milena Gasco; Tim Crook; Gareth J Inman
Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.
The Journal of clinical investigation 2010;120(8):2842-57.
2010: Justin G Julander; Ashok K Jha; Jung-Ae Choi; Kie-Hoon Jung; Donald F Smee; John D Morrey; Chung (David) K. Chu
Efficacy of 2'-C-methylcytidine against yellow fever virus in cell culture and in a hamster model.
Antiviral research 2010;86(3):261-7.
2010: Young Ah Kim; Ravindra K Rawal; Jakyung Yoo; Ashoke Sharon; Ashok K Jha; Chung (David) K. Chu; Reem H Rais; Omar N Al Safarjalani; Fardos N M Naguib; Mahmoud el Kouni
Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase.
Bioorganic & medicinal chemistry 2010;18(10):3403-12.
2010: Jagadeeshwar R Rao; Ashok K Jha; Ravindra K Rawal; Ashoke Sharon; Craig W Day; Dale L Barnard; Donald F Smee; Chung (David) K. Chu
(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
Bioorganic & medicinal chemistry letters 2010;20(8):2601-4.
2010: Jelena Mann; Chung (David) K. Chu; Aidan Maxwell; Fiona Oakley; Nian-Ling Zhu; Hidekazu Tsukamoto; Derek A Mann
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis.
Gastroenterology 2010;138(2):705-14, 714.e1-4.
2009: Marco Radi; Jagadeeshwar R Rao; Ashok K Jha; Chung (David) K. Chu
A convergent approach for the synthesis of ara-neplanocin a analogues under subzero microwave assisted conditions.
Nucleosides, nucleotides & nucleic acids 2009;28(5):504-18.
2009: Yuzeng Liang; Ashoke Sharon; Jason P Grier; Kimberly L Rapp; Ray F Schinazi; Chung (David) K. Chu
5'-O-Aliphatic and amino acid ester prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine (DOT): synthesis, anti-HIV activity, cytotoxicity and stability studies.
Bioorganic & medicinal chemistry 2009;17(3):1404-9.
2009: Hyo-Joong Kim; Ashoke Sharon; Chandralata Bal; Jianing Wang; Madhan Allu; Zhuhui Huang; Michael G Murray; Leda Bassit; Ray F Schinazi; Brent E Korba; Chung (David) K. Chu
Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro.
Journal of medicinal chemistry 2009;52(1):206-13.
2008: Ashoke Sharon; Chung (David) K. Chu
Understanding the molecular basis of HBV drug resistance by molecular modeling.
Antiviral research 2008;80(3):339-53.
2008: Justin G Julander; Richard A Bowen; Jagadeeshwar R Rao; Craig Day; Kristiina Shafer; Donald F Smee; John D Morrey; Chung (David) K. Chu
Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine.
Antiviral research 2008;80(3):309-15.
2008: Omar N Al Safarjalani; Reem H Rais; Young Ah Kim; Chung (David) K. Chu; Fardos N M Naguib; Mahmoud el Kouni
7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.
Biochemical pharmacology 2008;76(8):958-66.
2008: Young Ah Kim; Ashoke Sharon; Chung (David) K. Chu; Reem H Rais; Omar N Al Safarjalani; Fardos N M Naguib; Mahmoud el Kouni
Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase.
Journal of medicinal chemistry 2008;51(13):3934-45.
2007: Stephan Menne; Ghazia Asif; Jannan Narayanasamy; Scott D Butler; Andrea L George; Selwyn J Hurwitz; Ray F Schinazi; Chung (David) K. Chu; Paul J Cote; John L Gerin; Bud C Tennant
Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection.
Antimicrobial agents and chemotherapy 2007;51(9):3177-84.
2007: Janarthanan Narayanasamy; Manik R Pullagurla; Ashoke Sharon; Jianing Wang; Ray F Schinazi; Chung (David) K. Chu
Synthesis and anti-HIV activity of (-)-beta-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (-)-beta-D-(2R,4R)-1,3-dioxolane guanosine (DXG) prodrugs.
Antiviral research 2007;75(3):198-209.
2007: Ghazia Asif; Selwyn J Hurwitz; Aleksandr Obikhod; David Delinsky; Janarthanan Narayanasamy; Chung (David) K. Chu; Harold M McClure; Ray F Schinazi
Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys.
Antimicrobial agents and chemotherapy 2007;51(7):2424-9.
2007: Johan Lennerstrand; Chung (David) K. Chu; Ray F Schinazi
Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate.
Antimicrobial agents and chemotherapy 2007;51(6):2078-84.
2007: Young Ah Kim; Ashoke Sharon; Chung (David) K. Chu; Reem H Rais; Omar N Al Safarjalani; Fardos N M Naguib; Mahmoud el Kouni
Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents.
Biochemical pharmacology 2007;73(10):1558-72.
2007: Marco Radi; Auke D Adema; Jonathan R Daft; Jong H Cho; Eveline K Hoebe; Lou-Ella M M Alexander; Godefridus J Peters; Chung (David) K. Chu
In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs.
Journal of medicinal chemistry 2007;50(9):2249-53.
2007: Jianing Wang; Yunho Jin; Kimberly L Rapp; Ray F Schinazi; Chung (David) K. Chu
D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance.
Journal of medicinal chemistry 2007;50(8):1828-39.
2007: Jagadeeshwar R Rao; Ray F Schinazi; Chung (David) K. Chu
Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides.
Bioorganic & medicinal chemistry 2007;15(2):839-46.
2007: Auke D Adema; M Radi; J Daft; J Narayanasamy; Eveline K Hoebe; L E Alexander; Chung (David) K. Chu; Godefridus J Peters
Troxacitabine prodrugs for pancreatic cancer.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):1073-7.
2007: Adrian S Ray; Joy Y Feng; Eisuke Murakami; Chung (David) K. Chu; Ray F Schinazi; Karen S Anderson
Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma.
Antiviral chemistry & chemotherapy 2007;18(1):25-33.
2007: Donald F Smee; Miles K Wandersee; Kevin W Bailey; Min-Hui Wong; Chung (David) K. Chu; Srinivas Gadthula; Robert W Sidwell
Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice.
Antiviral research 2007;73(1):69-77.
2006: Hongwang Zhang; Ray F Schinazi; Chung (David) K. Chu
Synthesis of neplanocin F analogues as potential antiviral agents.
Bioorganic & medicinal chemistry 2006;14(24):8314-22.
2006: Yuzeng Liang; Janarthanan Narayanasamy; Ray F Schinazi; Chung (David) K. Chu
Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies.
Bioorganic & medicinal chemistry 2006;14(7):2178-89.
2006: Hyunah Choo; Xin Chen; Vikas Yadav; Jianing Wang; Ray F Schinazi; Chung (David) K. Chu
Synthesis and anti-HIV activity of D- and L-thietanose nucleosides.
Journal of medicinal chemistry 2006;49(5):1635-47.
2006: Jong Hyun Cho; Dale L Bernard; Robert W Sidwell; Earl R Kern; Chung (David) K. Chu
Synthesis of cyclopentenyl carbocyclic nucleosides as potential antiviral agents against orthopoxviruses and SARS.
Journal of medicinal chemistry 2006;49(3):1140-8.
2006: Balakumar Arumugham; Hyo-Joong Kim; Mark Prichard; Earl R Kern; Chung (David) K. Chu
Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus).
Bioorganic & medicinal chemistry letters 2006;16(2):285-7.
2006: Yuzeng Liang; Janarthanan Narayanasamy; Kim L Rapp; Ray F Schinazi; Chung (David) K. Chu
PAMAM dendrimers and branched polyethyleneglycol (nanoparticles) prodrugs of (-)-beta-D-(2R, 4R)-dioxolane-thymine (DOT) and their anti-HIV activity.
Antiviral chemistry & chemotherapy 2006;17(6):321-9.
2006: Chung (David) K. Chu; Srinivas Gadthula; Xin Chen; Hyunah Choo; Süreyya Olgen; Dale L Barnard; Robert W Sidwell
Antiviral activity of nucleoside analogues against SARS-coronavirus (SARS-coV).
Antiviral chemistry & chemotherapy 2006;17(5):285-9.
2005: Amol Gupte; John K Buolamwini; Vikas Yadav; Chung (David) K. Chu; Fardos N M Naguib; Mahmoud el Kouni
6-Benzylthioinosine analogues: promising anti-toxoplasmic agents as inhibitors of the mammalian nucleoside transporter ENT1 (es).
Biochemical pharmacology 2005;71(1-2):69-73.
2005: John Casey; Paul J Cote; Ilia A Toshkov; Chung (David) K. Chu; John L Gerin; William E Hornbuckle; Bud C Tennant; Brent E Korba
Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks.
Antimicrobial agents and chemotherapy 2005;49(10):4396-9.
2005: Jennifer L Hammond; Urvi M Parikh; Dianna L Koontz; Susan Schlueter-Wirtz; Chung (David) K. Chu; Holly Bazmi; Ray F Schinazi; John W Mellors
In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine.
Antimicrobial agents and chemotherapy 2005;49(9):3930-2.
2005: Seok-Rye Choi; Zhi-Ping Zhuang; Ann-Marie Chacko; Paul D Acton; Juri Tjuvajev-Gelovani; Mikhail Doubrovin; Chung (David) K. Chu; Hank F Kung
SPECT imaging of herpes simplex virus type1 thymidine kinase gene expression by [(123)I]FIAU(1).
Academic radiology 2005;12(7):798-805.
2005: Brenda I Hernandez-Santiago; Huachun Chen; Ghazia Asif; Thierry Beltran; Shuli Mao; Selwyn J Hurwitz; Jason Grier; Harold M McClure; Chung (David) K. Chu; Dennis C Liotta; Ray F Schinazi
Pharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeys.
Antimicrobial agents and chemotherapy 2005;49(7):2589-97.
2005: Chung (David) K. Chu; Vikas Yadav; Youhoon H Chong; Ray F Schinazi
Anti-HIV activity of (-)-(2R,4R)-1- (2-hydroxymethyl-1,3-dioxolan-4-yl)-thymine against drug-resistant HIV-1 mutants and studies of its molecular mechanism.
Journal of medicinal chemistry 2005;48(12):3949-52.
2005: Jianing Wang; Yunho Jin; Kimberly L Rapp; Matthew Bennett; Ray F Schinazi; Chung (David) K. Chu
Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides.
Journal of medicinal chemistry 2005;48(11):3736-48.
2005: Reem H Rais; Omar N Al Safarjalani; Vikas Yadav; Vincenzo Guarcello; Marion Kirk; Chung (David) K. Chu; Fardos N M Naguib; Mahmoud el Kouni
6-Benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.
Biochemical pharmacology 2005;69(10):1409-19.
2005: Adrian S Ray; Brenda I Hernandez-Santiago; Judy S Mathew; Eisuke Murakami; Carey Bozeman Clark; Meng-Yu Xie; Ginger E Dutschman; Elizabeth Gullen; Zhenjun Yang; Selwyn Hurwitz; Yung-Chi Cheng; Chung (David) K. Chu; Harold M McClure; Ray F Schinazi; Karen S Anderson
Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosine.
Antimicrobial agents and chemotherapy 2005;49(5):1994-2001.
2005: Urvi M Parikh; Dianna L Koontz; Chung (David) K. Chu; Ray F Schinazi; John W Mellors
In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase.
Antimicrobial agents and chemotherapy 2005;49(3):1139-44.
2005: Junxing Shi; Jinfa Du; Tianwei Ma; Krzysztof W Pankiewicz; Steven E Patterson; Phillip M Tharnish; Tamara R McBrayer; Lieven Stuyver; Michael J Otto; Chung (David) K. Chu; Ray F Schinazi; Kyoichi A Watanabe
Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.
Bioorganic & medicinal chemistry 2005;13(5):1641-52.
2005: Ghazia Asif; Selwyn J Hurwitz; Giuseppe Gumina; Chung (David) K. Chu; Harold M McClure; Ray F Schinazi
Pharmacokinetics of the antiviral agent beta-L-3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 2005;49(2):560-4.
2005: Srinivas Gadthula; Chung (David) K. Chu; Ray F Schinazi
Synthesis and anti-HIV activity of beta-D-3'-azido-2',3'-unsaturated nucleosides and beta-D-3'-azido-3'-deoxyribofuranosylnucleosides.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1707-27.
2005: Junxing Shi; Jinfa Du; Tianwei Ma; Krzysztof W Pankiewicz; Steven E Patterson; Abdalla E A Hassan; Phillip M Tharnish; Tamara R McBrayer; Stefania Lostia; Lieven Stuyver; Kyoichi A Watanabe; Chung (David) K. Chu; Ray F Schinazi; Michael J Otto
Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):875-9.
2005: S Balakrishna Pai; Rekha B Pai; Meng-yu Xie; Tolunay Beker; Junxing Shi; Phillip M Tharnish; Chung (David) K. Chu; Ray F Schinazi
Characterization of hepatitis B virus inhibition by novel 2'-fluoro-2',3'-unsaturated beta-D- and L-nucleosides.
Antiviral chemistry & chemotherapy 2005;16(3):183-92.
2004: Brenda I Hernandez-Santiago; Thierry Beltran; Lieven Stuyver; Chung (David) K. Chu; Ray F Schinazi
Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells.
Antimicrobial agents and chemotherapy 2004;48(12):4636-42.
2004: Xin Chen; Wen Zhou; Ray F Schinazi; Chung (David) K. Chu
Synthesis of 3'-fluoro-2',3'-dideoxy-2',3'-didehydro-4'-ethynyl-D- and -L-furanosyl nucleosides.
The Journal of organic chemistry 2004;69(18):6034-41.
2004: Vikas Yadav; Chung (David) K. Chu
Molecular mechanisms of adefovir sensitivity and resistance in HBV polymerase mutants: a molecular dynamics study.
Bioorganic & medicinal chemistry letters 2004;14(16):4313-7.
2004: LAVANYA BONDADA; Giuseppe Gumina; Ranjeet Nair; Xing Hai Ning; Ray F Schinazi; Chung (David) K. Chu
Synthesis of novel spiro[2.3]hexane carbocyclic nucleosides via enzymatic resolution.
Organic letters 2004;6(15):2531-4.
2004: Youhoon Chong; Chung (David) K. Chu
Molecular mechanism of dioxolane nucleosides against 3TC resistant M184V mutant HIV.
Antiviral research 2004;63(1):7-13.
2004: Wen Zhou; Giuseppe Gumina; Youhoon Chong; Jianing Wang; Ray F Schinazi; Chung (David) K. Chu
Synthesis, structure-activity relationships, and drug resistance of beta-d-3'-fluoro-2',3'-unsaturated nucleosides as anti-HIV Agents.
Journal of medicinal chemistry 2004;47(13):3399-408.
2004: Junxing Shi; Adrian S Ray; Judy S Mathew; Karen S Anderson; Chung (David) K. Chu; Ray F Schinazi
2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions.
Bioorganic & medicinal chemistry letters 2004;14(9):2159-62.
2004: Vikas Yadav; Chung (David) K. Chu; Reem H Rais; Omar N Al Safarjalani; Vincenzo Guarcello; Fardos N M Naguib; Mahmoud el Kouni
Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase.
Journal of medicinal chemistry 2004;47(8):1987-96.
2004: Wei Zhu; Youhoon Chong; Hyunah Choo; Judy Mathews; Ray F Schinazi; Chung (David) K. Chu
Synthesis, structure-activity relationships, and mechanism of drug resistance of D- and L-beta-3'-fluoro-2',3'-unsaturated-4'-thionucleosides as anti-HIV agents.
Journal of medicinal chemistry 2004;47(7):1631-40.
2004: Youhoon Chong; Hyunah Choo; Chung (David) K. Chu
Effects of fluorine substitution of cytosine analogues on the binding affinity to HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2004;14(2):437-40.
2004: Laurent Hollecker; Hyunah Choo; Youhoon Chong; Chung (David) K. Chu; Stefania Lostia; Tamara R McBrayer; Lieven Stuyver; J Christian Mason; Jinfa Du; Suguna Rachakonda; Junxing Shi; Ray F Schinazi; Kyochi A Watanabe
Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture.
Antiviral chemistry & chemotherapy 2004;15(1):43-55.
2004: Youhoon Chong; Chung (David) K. Chu
Understanding the molecular mechanism of drug resistance of anti-HIV nucleosides by molecular modeling.
Frontiers in bioscience : a journal and virtual library 2004;9():164-86.
2004: Eun-Mi Park; Tong H Joh; Bruce T Volpe; Chung (David) K. Chu; G Song; Sunghee Cho
A neuroprotective role of extracellular signal-regulated kinase in N-acetyl-O-methyldopamine-treated hippocampal neurons after exposure to in vitro and in vivo ischemia.
Neuroscience 2004;123(1):147-54.
2003: Youhoon Chong; Nagaraju Akula; Chung (David) K. Chu
Studies of molecular mechanism of tenofovir against 3TC- and AZT-resistance mutant HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2003;13(22):4019-22.
2003: Yun H Jin; Peng Liu; Jianing Wang; Udayan Das; Robert Baker; John Huggins; Chung (David) K. Chu
Practical synthesis of D- and l-2-cyclopentenone and their utility for the synthesis of carbocyclic antiviral nucleosides against orthopox viruses (smallpox, monkeypox, and cowpox virus).
The Journal of organic chemistry 2003;68(23):9012-8.
2003: Youhoon Chong; Lieven Stuyver; Michael J Otto; Ray F Schinazi; Chung (David) K. Chu
Mechanism of antiviral activities of 3'-substituted L-nucleosides against 3TC-resistant HBV polymerase: a molecular modelling approach.
Antiviral chemistry & chemotherapy 2003;14(6):309-19.
2003: Linghui Kong; John S Cooperwood; Chang H Oh; Chung (David) K. Chu; F Douglas Boudinot
Simultaneous determination of 3'-azido-2',3'-dideoxyuridine and novel prodrugs in rat plasma by liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;795(2):371-6.
2003: Lieven Stuyver; Tamara R McBrayer; Phillip M Tharnish; Abdalla E A Hassan; Chung (David) K. Chu; Krzysztof W Pankiewicz; Kyochi A Watanabe; Ray F Schinazi; Michael J Otto
Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites.
Journal of virology 2003;77(19):10689-94.
2003: Linghui Kong; John S Cooperwood; Shu-Hui Christine Huang; Chung (David) K. Chu; F Douglas Boudinot
Pharmacokinetic evaluation of 3'-azido-2', 3'-dideoxyuridine-5'-O-valinate-hydrochloride as a prodrug of the anti-HIV nucleoside 3'-azido-2', 3'-dideoxyuridine.
Antiviral chemistry & chemotherapy 2003;14(5):263-70.
2003: Adrian S Ray; Eisuke Murakami; Aravind Basavapathruni; Joseph A Vaccaro; Dagny Ulrich; Chung (David) K. Chu; Ray F Schinazi; Karen S Anderson
Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis.
Biochemistry 2003;42(29):8831-41.
2003: Youhoon Chong; Giuseppe Gumina; Judy S Mathew; Ray F Schinazi; Chung (David) K. Chu
l-2',3'-Didehydro-2',3'-dideoxy-3'-fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance.
Journal of medicinal chemistry 2003;46(15):3245-56.
2003: Hyunah Choo; Youhoon Chong; Chung (David) K. Chu
The role of 2',3'-unsaturation on the antiviral activity of anti-HIV nucleosides against 3TC-resistant mutant (M184V).
Bioorganic & medicinal chemistry letters 2003;13(12):1993-6.
2003: Huachun Chen; S Balakrishna Pai; Selwyn J Hurwitz; Chung (David) K. Chu; Yuliya Glazkova; Harold M McClure; Mark A Feitelson; Ray F Schinazi
Antiviral activity and pharmacokinetics of 1-(2,3-dideoxy-2-fluoro-beta-L-glyceropent-2-enofuranosyl)cytosine.
Antimicrobial agents and chemotherapy 2003;47(6):1922-8.
2003: Y H Jin; Chung (David) K. Chu
Practical synthesis of D-cyclopent-2-enone, the key intermediate of carbocyclic nucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):771-3.
2003: Youhoon Chong; Hyunah Choo; Ray F Schinazi; Chung (David) K. Chu
2'-Fluoro-4'-thio-2',3'-unsaturated nucleosides: anti-HIV activity, resistance profile, and molecular modeling studies.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):611-5.
2003: Adrian S Ray; Ray F Schinazi; Eisuke Murakami; Aravind Basavapathruni; Junxing Shi; Suzana M Zorca; Chung (David) K. Chu; Karen S Anderson
Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase.
Antiviral chemistry & chemotherapy 2003;14(3):115-25.
2003: Hyunah Choo; Youhoon Chong; Yongseok Choi; Judy Mathew; Ray F Schinazi; Chung (David) K. Chu
Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.
Journal of medicinal chemistry 2003;46(3):389-98.
2003: Chung (David) K. Chu; Y H Jin; R O Baker; John W Huggins
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox).
Bioorganic & medicinal chemistry letters 2003;13(1):9-12.
2003: Lieven Stuyver; Tony Whitaker; Tamara R McBrayer; Brenda I Hernandez-Santiago; Stefania Lostia; Phillip M Tharnish; Mangala Ramesh; Chung (David) K. Chu; Robert Jordan; Junxing Shi; Suguna Rachakonda; Kyoichi A Watanabe; Michael J Otto; Ray F Schinazi
Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.
Antimicrobial agents and chemotherapy 2003;47(1):244-54.
2002: Youhoon Chong; Chung (David) K. Chu
Understanding the unique mechanism of L-FMAU (clevudine) against hepatitis B virus: molecular dynamics studies.
Bioorganic & medicinal chemistry letters 2002;12(23):3459-62.
2002: Lieven Stuyver; Stefania Lostia; Marjorie Adams; Judy S Mathew; Balakrishna S Pai; Jason Grier; Phillip M Tharnish; Yongseok Choi; Youhoon Chong; Hyunah Choo; Chung (David) K. Chu; Michael J Otto; Ray F Schinazi
Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.
Antimicrobial agents and chemotherapy 2002;46(12):3854-60.
2002: Youhoon Chong; Hyunah Choo; Yongseok Choi; Judy Mathew; Ray F Schinazi; Chung (David) K. Chu
Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.
Journal of medicinal chemistry 2002;45(22):4888-98.
2002: Giuseppe Gumina; Youhoon Chong; Hyunah Choo; Gyu-Yong Song; Chung (David) K. Chu
L-nucleosides: antiviral activity and molecular mechanism.
Current topics in medicinal chemistry 2002;2(10):1065-86.
2002: Stacy D Brown; Catherine A White; Chung (David) K. Chu; Michael G Bartlett
Determination of acyclovir in maternal plasma, amniotic fluid, fetal and placental tissues by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;772(2):327-34.
2002: Adrian S Ray; Zhenjun Yang; Junxing Shi; Ann Hobbs; Ray F Schinazi; Chung (David) K. Chu; Karen S Anderson
Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate.
Biochemistry 2002;41(16):5150-62.
2002: Giuseppe Gumina; Chung (David) K. Chu
Synthesis of L-oxetanocin.
Organic letters 2002;4(7):1147-9.
2002: Kyeong Lee; Yongseok Choi; Giuseppe Gumina; Wen Zhou; Ray F Schinazi; Chung (David) K. Chu
Structure-activity relationships of 2'-fluoro-2',3'-unsaturated D-nucleosides as anti-HIV-1 agents.
Journal of medicinal chemistry 2002;45(6):1313-20.
2002: Youhoon Chong; Katyna Borroto-Esoda; Phillip A Furman; Ray F Schinazi; Chung (David) K. Chu
Molecular mechanism of DApd/DXG against zidovudine- and lamivudine- drug resistant mutants: a molecular modelling approach.
Antiviral chemistry & chemotherapy 2002;13(2):115-28.
2002: Youhoon Chong; Chung (David) K. Chu
Efficient synthesis of 2-deoxy-L-erythro-pentose (2-deoxy-L-ribose) from L-arabinose.
Carbohydrate research 2002;337(5):397-402.
2002: Adrian S Ray; Zhenjun Yang; Chung (David) K. Chu; Karen S Anderson
Novel use of a guanosine prodrug approach to convert 2',3'-didehydro-2',3'-dideoxyguanosine into a viable antiviral agent.
Antimicrobial agents and chemotherapy 2002;46(3):887-91.
2002: Yongseok Choi; Hyunah Choo; Youhoon Chong; Sookwang Lee; Süreyya Olgen; Ray F Schinazi; Chung (David) K. Chu
Synthesis and potent anti-HIV activity of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine.
Organic letters 2002;4(2):305-7.
2001: Giuseppe Gumina; Ray F Schinazi; Chung (David) K. Chu
Synthesis and potent anti-HIV activity of L-3'-fluoro-2',3'-unsaturated cytidine.
Organic letters 2001;3(26):4177-80.
2001: G Y Song; Fardos N M Naguib; Mahmoud el Kouni; Chung (David) K. Chu
Synthesis of carbocyclic orotidine analogs as potential orotidine decarboxylase inhibitors.
Nucleosides, nucleotides & nucleic acids 2001;20(12):1915-25.
2001: Gyu-Yong Song; V Paul; H Choo; J Morrey; R W Sidwell; Ray F Schinazi; Chung (David) K. Chu
Enantiomeric synthesis of D- and L-cyclopentenyl nucleosides and their antiviral activity against HIV and West Nile virus.
Journal of medicinal chemistry 2001;44(23):3985-93.
2001: Giuseppe Gumina; Gyu-Yong Song; Chung (David) K. Chu
L-Nucleosides as chemotherapeutic agents.
FEMS microbiology letters 2001;202(1):9-15.
2001: BK Chun; Gyu-Yong Song; Chung (David) K. Chu
Stereocontrolled syntheses of carbocyclic C-nucleosides and related compounds.
The Journal of organic chemistry 2001;66(14):4852-8.
2001: Hyunah Choo; Youhoon Chong; Chung (David) K. Chu
Solid phase synthesis of carbocyclic l-2'-deoxynucleosides.
Organic letters 2001;3(10):1471-3.
2001: T Nicole Clark; Catherine A White; Chung (David) K. Chu; Michael G Bartlett
Determination of 3'-azido-2',3'-dideoxyuridine in maternal plasma, amniotic fluid, fetal and placental tissues by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2001;755(1-2):165-72.
2001: Kyeong Lee; Youhoon Chong; Chung (David) K. Chu
Understanding the mode of action of L-nucleosides as antiviral agents: a molecular modeling approach.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):385-8.
2001: Sunghee Cho; Y Kim; M O Cruz; Eun-Mi Park; Chung (David) K. Chu; G Y Song; Tong H Joh
Repression of proinflammatory cytokine and inducible nitric oxide synthase (NOS2) gene expression in activated microglia by N-acetyl-O-methyldopamine: protein kinase A-dependent mechanism.
Glia 2001;33(4):324-33.
2001: Giuseppe Gumina; Gyu-Yong Song; Chung (David) K. Chu
Advances in antiviral agents for hepatitis B virus.
Antiviral chemistry & chemotherapy 2001;12 Suppl 1():93-117.
2001: Simon F Peek; Paul J Cote; James R Jacob; Ilia A Toshkov; William E Hornbuckle; Betty H Baldwin; Frances V Wells; Chung (David) K. Chu; John L Gerin; Bud C Tennant; Brent E Korba
Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-beta, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax).
Hepatology (Baltimore, Md.) 2001;33(1):254-66.
2001: Phillip A Furman; Jerry L Jeffrey; L L Kiefer; Joy Y Feng; Karen S Anderson; Katyna Borroto-Esoda; E Hill; W C Copeland; Chung (David) K. Chu; J P Sommadossi; I Liberman; Ray F Schinazi; George Painter
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.
Antimicrobial agents and chemotherapy 2001;45(1):158-65.
2001: Kyeong Lee; Chung (David) K. Chu
Molecular modeling approach to understanding the mode of action of L-nucleosides as antiviral agents.
Antimicrobial agents and chemotherapy 2001;45(1):138-44.
2000: T Kira; Susan P Grill; Ginger E Dutschman; J S Lin; F Qu; Yongseok Choi; Chung (David) K. Chu; Yung-Chi Cheng
Anti-Epstein-Barr virus (EBV) activity of beta-L-5-iododioxolane uracil is dependent on EBV thymidine kinase.
Antimicrobial agents and chemotherapy 2000;44(12):3278-84.
2000: Ling Li; Ginger E Dutschman; Elizabeth Gullen; E Tsujii; Susan P Grill; Yongseok Choi; Chung (David) K. Chu; Yung-Chi Cheng
Metabolism and mode of inhibition of varicella-zoster virus by L-beta-5-bromovinyl-(2-hydroxymethyl)-(1,3-dioxolanyl)uracil is dependent on viral thymidine kinase.
Molecular pharmacology 2000;58(5):1109-14.
2000: Chung (David) K. Chu; L Ma; Süreyya Olgen; C Pierra; J Du; Giuseppe Gumina; Elizabeth Gullen; Yung-Chi Cheng; Ray F Schinazi
Synthesis and antiviral activity of oxaselenolane nucleosides.
Journal of medicinal chemistry 2000;43(21):3906-12.
2000: AJR Chun; Ray F Schinazi; Yung-Chi Cheng; Chung (David) K. Chu
Synthesis of 2',3'-dideoxy-3'-fluoro-L-ribonucleosides as potential antiviral agents from D-sorbitol.
Carbohydrate research 2000;328(1):49-59.
2000: J H Hong; M Y Gao; Yongseok Choi; Yung-Chi Cheng; Ray F Schinazi; Chung (David) K. Chu
Synthesis of novel 3'-C-methyl-apionucleosides: an asymmetric construction of a quaternary carbon by Claisen rearrangement.
Carbohydrate research 2000;328(1):37-48.
2000: Holly Bazmi; Jennifer L Hammond; S C Cavalcanti; Chung (David) K. Chu; Ray F Schinazi; John W Mellors
In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine.
Antimicrobial agents and chemotherapy 2000;44(7):1783-8.
2000: Yongseok Choi; Ling Li; Susan P Grill; Elizabeth Gullen; C S Lee; Giuseppe Gumina; E Tsujii; Yung-Chi Cheng; Chung (David) K. Chu
Structure-activity relationships of (E)-5-(2-bromovinyl)uracil and related pyrimidine nucleosides as antiviral agents for herpes viruses.
Journal of medicinal chemistry 2000;43(13):2538-46.
2000: X Tan; F Douglas Boudinot; Chung (David) K. Chu; David Egron; C Perigaud; Gilles Gosselin; Jean-Louis Imbach
Pharmacokinetics of bis(t-butyl-SATE)-AZTMP, a bispivaloylthioethyl prodrug for intracellular delivery of zidovudine monophosphate, in mice.
Antiviral chemistry & chemotherapy 2000;11(3):203-11.
2000: BK Chun; Süreyya Olgen; J H Hong; MG Newton; Chung (David) K. Chu
Enantiomeric syntheses of conformationally restricted D- and L-2', 3'-dideoxy-2',3'-endo-methylene nucleosides from carbohydrate chiral templates.
The Journal of organic chemistry 2000;65(3):685-93.
2000: C Pierra; Süreyya Olgen; S C Cavalcanti; Yung-Chi Cheng; Ray F Schinazi; Chung (David) K. Chu
Synthesis and antiviral activities of enantiomeric 1-[2-(hydroxymethyl) cyclopropyl] methyl nucleosides.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):253-68.
2000: John S Cooperwood; V Boyd; Giuseppe Gumina; Chung (David) K. Chu
Synthesis of L-3'-hydroxymethylribonucleosides.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):219-36.
1999: H Chen; Ray F Schinazi; P Rajagopalan; Z Gao; Chung (David) K. Chu; H M McClure; F Douglas Boudinot
Pharmacokinetics of (-)-beta-D-dioxolane guanine and prodrug (-)-beta-D-2,6-diaminopurine dioxolane in rats and monkeys.
AIDS research and human retroviruses 1999;15(18):1625-30.
1999: David M Brown; Andrew G Netting; AJR Chun; Y Choi; Chung (David) K. Chu; Annette M Gero
L-nucleoside analogues as potential antimalarials that selectively target Plasmodium falciparum adenosine deaminase.
Nucleosides & nucleotides 1999;18(11-12):2521-32.
1999: S C Cavalcanti; Y Xiang; MG Newton; Ray F Schinazi; Yung-Chi Cheng; Chung (David) K. Chu
Synthesis of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides as potential antiviral agents.
Nucleosides & nucleotides 1999;18(10):2233-52.
1999: P Wang; B Gullen; MG Newton; Yung-Chi Cheng; Ray F Schinazi; Chung (David) K. Chu
Asymmetric synthesis and antiviral activities of L-carbocyclic 2', 3'-didehydro-2',3'-dideoxy and 2',3'-dideoxy nucleosides.
Journal of medicinal chemistry 1999;42(17):3390-9.
1999: P P Wang; Lakshmi P Kotra; Chung (David) K. Chu; Michael G Bartlett
Structure determination of 4-azido-2-pyrimidinone nucleoside analogs using mass spectrometry.
Journal of mass spectrometry : JMS 1999;34(7):724-32.
1999: J S Lin; T Kira; Elizabeth Gullen; Yongseok Choi; F Qu; Chung (David) K. Chu; Yung-Chi Cheng
Structure-activity relationships of L-dioxolane uracil nucleosides as anti-Epstein Barr virus agents.
Journal of medicinal chemistry 1999;42(12):2212-7.
1999: Kyeong Lee; Yongseok Choi; Elizabeth Gullen; S Schlueter-Wirtz; Ray F Schinazi; Yung-Chi Cheng; Chung (David) K. Chu
Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2', 3'-unsaturated L-nucleosides.
Journal of medicinal chemistry 1999;42(7):1320-8.
1999: Annette M Gero; G Perrone; David M Brown; ST Hall; Chung (David) K. Chu
L-purine nucleosides as selective antimalarials.
Nucleosides & nucleotides 1999;18(4-5):885-9.
1999: K Lee; Yongseok Choi; J H Hong; Ray F Schinazi; Chung (David) K. Chu
New classes of fluorinated L-nucleosides; synthesis and antiviral activity.
Nucleosides & nucleotides 1999;18(4-5):537-40.
1999: J Du; Yongseok Choi; Kyeong Lee; BK Chun; J H Hong; Chung (David) K. Chu
A practical synthesis of L-FMAU from L-arabinose.
Nucleosides & nucleotides 1999;18(2):187-95.
1999: S Cho; Bruce T Volpe; Y Bae; Onyou Hwang; H J Choi; J Gal; Larry C H Park; Chung (David) K. Chu; J Du; Tong H Joh
Blockade of tetrahydrobiopterin synthesis protects neurons after transient forebrain ischemia in rat: a novel role for the cofactor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(3):878-89.
1998: P Wang; J H Hong; J S Cooperwood; Chung (David) K. Chu
Recent advances in L-nucleosides: chemistry and biology.
Antiviral research 1998;40(1-2):19-44.
1998: P Wang; Ray F Schinazi; Chung (David) K. Chu
Asymmetric synthesis and anti-HIV activity of L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine.
Bioorganic & medicinal chemistry letters 1998;8(13):1585-8.
1998: AS Xu; Chung (David) K. Chu; Robert E London
19F NMR study of the uptake of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil in erythrocytes: evidence of transport by facilitated and nonfacilitated pathways.
Biochemical pharmacology 1998;55(10):1611-9.
1998: J H Hong; Y Choi; AJR Chun; K Lee; Chung (David) K. Chu
Current status of anti-HBV chemotherapy.
Archives of pharmacal research 1998;21(2):89-105.
1998: S Aguesse-Germon; S H Liu; Michèle Chevallier; Christian Pichoud; Catherine Jamard; Christelle Borel; Chung (David) K. Chu; Christian Trépo; YC Cheng; Fabien Zoulim
Inhibitory effect of 2'-fluoro-5-methyl-beta-L-arabinofuranosyl-uracil on duck hepatitis B virus replication.
Antimicrobial agents and chemotherapy 1998;42(2):369-76.
1998: Chung (David) K. Chu; F Douglas Boudinot; Simon F Peek; J H Hong; Y Choi; Brent E Korba; John L Gerin; Paul J Cote; Bud C Tennant; Y C Cheng
Preclinical investigation of L-FMAU as an anti-hepatitis B virus agent.
Antiviral therapy 1998;3(Suppl 3):113-21.
1998: J Du; Chung (David) K. Chu
Asymmetric synthesis of oxazolidine nucleosides and related chemistry.
Nucleosides & nucleotides 1998;17(1-3):1-13.
1998: Lakshmi P Kotra; MG Newton; Chung (David) K. Chu
Synthesis of 2,3-dideoxy-2,2-difluoro-L-glycero-pentofuranosyl nucleosides.
Carbohydrate research 1998;306(1-2):69-80.
1997: Lakshmi P Kotra; Y Xiang; MG Newton; Ray F Schinazi; YC Cheng; Chung (David) K. Chu
Structure-activity relationships of 2'-deoxy-2',2'-difluoro-L-erythro-pentofuranosyl nucleosides.
Journal of medicinal chemistry 1997;40(22):3635-44.
1997: J W Witcher; F Douglas Boudinot; Betty H Baldwin; MA Ascenzi; Bud C Tennant; J F Du; Chung (David) K. Chu
Pharmacokinetics of 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)uracil in woodchucks.
Antimicrobial agents and chemotherapy 1997;41(10):2184-7.
1997: J Du; S Surzhykov; J S Lin; MG Newton; YC Cheng; Ray F Schinazi; Chung (David) K. Chu
Synthesis, anti-human immunodeficiency virus and anti-hepatitis B virus activities of novel oxaselenolane nucleosides.
Journal of medicinal chemistry 1997;40(19):2991-3.
1997: C Liang; T Ma; J S Cooperwood; J Du; Chung (David) K. Chu
Synthesis of L-ribofuranosyl C-nucleosides.
Carbohydrate research 1997;303(1):33-8.
1997: T Ma; J S Lin; MG Newton; YC Cheng; Chung (David) K. Chu
Synthesis and anti-hepatitis B virus activity of 9-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl) purine nucleosides.
Journal of medicinal chemistry 1997;40(17):2750-4.
1997: KK Manouilov; L S Manouilova; F Douglas Boudinot; Ray F Schinazi; Chung (David) K. Chu
Biotransformation and pharmacokinetics of prodrug 9-(beta-D-1,3-dioxolan-4-yl)-2-aminopurine and its antiviral metabolite 9-(beta-D-1,3-dioxolan-4-yl)guanine in mice.
Antiviral research 1997;35(3):187-93.
1997: KK Manouilov; Z S Xu; F Douglas Boudinot; Ray F Schinazi; Chung (David) K. Chu
Lymphatic targeting of anti-HIV nucleosides: distribution of 2',3'-dideoxyinosine after intravenous and oral administration of dipalmitoylphosphatidyl prodrug in mice.
Antiviral research 1997;34(3):91-9.
1997: H Chen; KK Manouilov; Chung (David) K. Chu; Ray F Schinazi; H M McClure; F Douglas Boudinot
High-performance liquid chromatographic determination of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane, and their metabolite (-)-beta-D-dioxolane guanine in monkey serum, urine and cerebrospinal fluid.
Journal of chromatography. B, Biomedical sciences and applications 1997;691(2):425-32.
1997: L E Moore; F Douglas Boudinot; Chung (David) K. Chu
Preclinical pharmacokinetics of beta-L-dioxolane-cytidine, a novel anticancer agent, in rats.
Cancer chemotherapy and pharmacology 1997;39(6):532-6.
1996: Lakshmi P Kotra; K K Manouilov; Erika Cretton-Scott; Jean-Pierre Sommadossi; F Douglas Boudinot; Ray F Schinazi; Chung (David) K. Chu
Synthesis, biotransformation, and pharmacokinetic studies of 9-(beta-D-arabinofuranosyl)-6-azidopurine: a prodrug for ara-A designed to utilize the azide reduction pathway.
Journal of medicinal chemistry 1996;39(26):5202-7.
1996: L Cui; Ray F Schinazi; Gilles Gosselin; Jean-Louis Imbach; Chung (David) K. Chu; RF Rando; G R Revankar; Jean-Pierre Sommadossi
Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity.
Biochemical pharmacology 1996;52(10):1577-84.
1996: T Koudriakova; K K Manouilov; K Shanmuganathan; Lakshmi P Kotra; F Douglas Boudinot; Erika Cretton-Scott; Jean-Pierre Sommadossi; Ray F Schinazi; Chung (David) K. Chu
In vitro and in vivo evaluation of 6-azido-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosylpurine and N6-methyl-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosyladenine as prodrugs of the anti-HIV nucleosides 2'-F-ara-ddA and 2'-F-ara-ddI.
Journal of medicinal chemistry 1996;39(23):4676-81.
1996: H Chen; F Douglas Boudinot; Chung (David) K. Chu; H M Mcclure; Ray F Schinazi
Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1996;40(10):2332-6.
1996: T Ma; S Balakrishna Pai; Y L Zhu; J S Lin; K Shanmuganathan; J Du; C Wang; H Kim; M G Newton; Yung-Chi Cheng; Chung (David) K. Chu
Structure--activity relationships of 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)pyrimidine nucleosides as anti-hepatitis B virus agents.
Journal of medicinal chemistry 1996;39(14):2835-43.
1996: Mahmoud el Kouni; Fardos N M Naguib; R P Panzica; B A Otter; S H Chu; Gilles Gosselin; Chung (David) K. Chu; Ray F Schinazi; Y F Shealy; N Goudgaon; A A Ozerov; T Ueda; M H Iltzsch
Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii.
Biochemical pharmacology 1996;51(12):1687-700.
1996: C I Hong; A Nechaev; A J Kirisits; R Vig; C R West; K K Manouilov; Chung (David) K. Chu
Nucleoside conjugates. 15. Synthesis and biological activity of anti-HIV nucleoside conjugates of ether and thioether phospholipids.
Journal of medicinal chemistry 1996;39(9):1771-7.
1996: G Q Yao; SH Liu; E Chou; M Kukhanova; Chung (David) K. Chu; Yung-Chi Cheng
Inhibition of Epstein-Barr virus replication by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.
Biochemical pharmacology 1996;51(7):941-7.
1996: J D Wright; T Ma; Chung (David) K. Chu; F Douglas Boudinot
Discontinuous oral absorption pharmacokinetic model and bioavailability of 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)uracil (L-FMAU) in rats.
Biopharmaceutics & drug disposition 1996;17(3):197-207.
1996: P Rajagopalan; F Douglas Boudinot; Chung (David) K. Chu; Bud C Tennant; Betty H Baldwin; Ray F Schinazi
Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks.
Antimicrobial agents and chemotherapy 1996;40(3):642-5.
1996: S Balakrishna Pai; SH Liu; Y L Zhu; Chung (David) K. Chu; Yung-Chi Cheng
Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil.
Antimicrobial agents and chemotherapy 1996;40(2):380-6.
1995: P Rajagopalan; Z Gao; Chung (David) K. Chu; Ray F Schinazi; H M McClure; F Douglas Boudinot
High-performance liquid chromatographic determination of (-)-beta-D-2,6-diaminopurine dioxolane and its metabolite, dioxolane guanosine, using ultraviolet and on-line radiochemical detection.
Journal of chromatography. B, Biomedical applications 1995;672(1):119-24.
1995: M Kukhanova; S H Liu; D Mozzherin; T S Lin; Chung (David) K. Chu; Yung-Chi Cheng
L- and D-enantiomers of 2',3'-dideoxycytidine 5'-triphosphate analogs as substrates for human DNA polymerases. Implications for the mechanism of toxicity.
The Journal of biological chemistry 1995;270(39):23055-9.
1995: E C Mar; Chung (David) K. Chu; J C Lin
Some nucleoside analogs with anti-human immunodeficiency virus activity inhibit replication of Epstein-Barr virus.
Antiviral research 1995;28(1):1-11.
1995: J D Wright; T Ma; Chung (David) K. Chu; F Douglas Boudinot
Pharmacokinetics of 1-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (L-FMAU) in rats.
Pharmaceutical research 1995;12(9):1350-3.
1995: K L Grove; X Guo; SH Liu; Z Gao; Chung (David) K. Chu; Yung-Chi Cheng
Anticancer activity of beta-L-dioxolane-cytidine, a novel nucleoside analogue with the unnatural L configuration.
Cancer research 1995;55(14):3008-11.
1995: K K Manouilov; C A White; F Douglas Boudinot; I I Fedorov; Chung (David) K. Chu
Lymphatic distribution of 3'-azido-3'-deoxythymidine and 3'-azido-2',3'-dideoxyuridine in mice.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(6):655-8.
1995: Chung (David) K. Chu; T Ma; K Shanmuganathan; C Wang; Y Xiang; S Balakrishna Pai; G Q Yao; Jean-Pierre Sommadossi; Yung-Chi Cheng
Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus.
Antimicrobial agents and chemotherapy 1995;39(4):979-81.
1994: Ray F Schinazi; Gilles Gosselin; Abdesslem Faraj; B E Korba; Dennis C Liotta; Chung (David) K. Chu; Christophe Mathé; Jean-Louis Imbach; Jean-Pierre Sommadossi
Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro.
Antimicrobial agents and chemotherapy 1994;38(9):2172-4.
1994: L B Hendry; Chung (David) K. Chu; M L Rosser; J A Copland; J C Wood; Virendra B Mahesh
Design of novel antiestrogens.
The Journal of steroid biochemistry and molecular biology 1994;49(4-6):269-80.
1994: L B Hendry; Chung (David) K. Chu; J A Copland; Virendra B Mahesh
Antiestrogenic piperidinediones designed prospectively using computer graphics and energy calculations of DNA-ligand complexes.
The Journal of steroid biochemistry and molecular biology 1994;48(5-6):495-505.
1994: K Shanmuganathan; T Koudriakova; S Nampalli; J Du; J M Gallo; Ray F Schinazi; Chung (David) K. Chu
Enhanced brain delivery of an anti-HIV nucleoside 2'-F-ara-ddI by xanthine oxidase mediated biotransformation.
Journal of medicinal chemistry 1994;37(6):821-7.
1994: M Qian; X Wang; K Shanmuganathan; Chung (David) K. Chu; J M Gallo
Pharmacokinetics of the anticancer agent 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine in rats.
Cancer chemotherapy and pharmacology 1994;33(6):484-8.
1993: J A Copland; L B Hendry; Chung (David) K. Chu; J C Wood; RW Wrenn; C G Pantazis; Virendra B Mahesh
Inhibition of estrogen stimulated mitogenesis by 3-phenylacetylamino-2,6-piperidinedione and its para-hydroxy analog.
The Journal of steroid biochemistry and molecular biology 1993;46(4):451-62.
1993: Lak Shin Jeong; Ray F Schinazi; J Warren Beach; H O Kim; K Shanmuganathan; S Nampalli; Moon Woo Chun; W K Chung; B G Choi; Chung (David) K. Chu
Structure-activity relationships of beta-D-(2S,5R)- and alpha-D-(2S,5S)-1,3-oxathiolanyl nucleosides as potential anti-HIV agents.
Journal of medicinal chemistry 1993;36(18):2627-38.
1993: F Douglas Boudinot; Ray F Schinazi; K J Doshi; H M McClure; Chung (David) K. Chu
Pharmacokinetics and metabolism of 3'-azido-2',3'-dideoxy-5-methylcytidine in rhesus monkeys.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(5):855-60.
1993: Ray F Schinazi; R M Lloyd; M H Nguyen; D L Cannon; A McMillan; N Ilksoy; Chung (David) K. Chu; Dennis C Liotta; H Z Bazmi; J W Mellors
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides.
Antimicrobial agents and chemotherapy 1993;37(4):875-81.
1993: H O Kim; Ray F Schinazi; K Shanmuganathan; Lak Shin Jeong; J Warren Beach; S Nampalli; D L Cannon; Chung (David) K. Chu
L-beta-(2S,4S)- and L-alpha-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships.
Journal of medicinal chemistry 1993;36(5):519-28.
1993: Lak Shin Jeong; Ray F Schinazi; J Warren Beach; H O Kim; S Nampalli; K Shanmuganathan; A J Alves; A McMillan; Chung (David) K. Chu; R Mathis
Asymmetric synthesis and biological evaluation of beta-L-(2R,5S)- and alpha-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents.
Journal of medicinal chemistry 1993;36(2):181-95.
1993: H O Kim; Ray F Schinazi; S Nampalli; K Shanmuganathan; D L Cannon; A J Alves; Lak Shin Jeong; J Warren Beach; Chung (David) K. Chu
1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes.
Journal of medicinal chemistry 1993;36(1):30-7.
1992: Jean-Pierre Sommadossi; Ray F Schinazi; Chung (David) K. Chu; M Y Xie
Comparison of cytotoxicity of the (-)- and (+)-enantiomer of 2',3'-dideoxy-3'-thiacytidine in normal human bone marrow progenitor cells.
Biochemical pharmacology 1992;44(10):1921-5.
1992: E M Cretton; M Y Xie; N M Goudgaon; Ray F Schinazi; Chung (David) K. Chu; Jean-Pierre Sommadossi
Catabolic disposition of 3'-azido-2',3'-dideoxyuridine in hepatocytes with evidence of azido reduction being a general catabolic pathway of 3'-azido-2',3'-dideoxynucleosides.
Biochemical pharmacology 1992;44(5):973-80.
1992: C N Chang; S L Doong; J H Zhou; J Warren Beach; Lak Shin Jeong; Chung (David) K. Chu; C H Tsai; Yung-Chi Cheng; Dennis C Liotta; Ray F Schinazi
Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.
The Journal of biological chemistry 1992;267(20):13938-42.
1992: H O Kim; S K Ahn; A J Alves; J Warren Beach; Lak Shin Jeong; B G Choi; P Van Roey; Ray F Schinazi; Chung (David) K. Chu
Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.
Journal of medicinal chemistry 1992;35(11):1987-95.
1992: Ray F Schinazi; Chung (David) K. Chu; A Peck; A McMillan; R Mathis; D Cannon; Lak Shin Jeong; J Warren Beach; W B Choi; S Yeola
Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.
Antimicrobial agents and chemotherapy 1992;36(3):672-6.
1991: J M Gallo; J T Etse; K J Doshi; F Douglas Boudinot; Chung (David) K. Chu
Hybrid pharmacokinetic models to describe anti-HIV nucleoside brain disposition following parent and prodrug administration in mice.
Pharmaceutical research 1991;8(2):247-53.
1990: Z Zhu; Ray F Schinazi; Chung (David) K. Chu; G J Williams; C B Colby; Jean-Pierre Sommadossi
Cellular metabolism of 3'-azido-2',3'-dideoxyuridine with formation of 5'-O-diphosphohexose derivatives by previously unrecognized metabolic pathways for 2'-deoxyuridine analogs.
Molecular pharmacology 1990;38(6):929-38.
1990: K Hirota; H Hosono; Y Kitade; Y Maki; Chung (David) K. Chu; Ray F Schinazi; H Nakane; K Ono
Synthesis and anti-human immunodeficiency virus (HIV-1) activity of 3'-deoxy-3'-(triazol-1-yl)thymidines and 2',3'-dideoxy-3'-(triazol-1-yl)uridines and inhibition of reverse transcriptase by their 5'-triphosphates.
Chemical & pharmaceutical bulletin 1990;38(9):2597-601.
1990: Chung (David) K. Chu; V S Bhadti; K J Doshi; J T Etse; J M Gallo; F Douglas Boudinot; Ray F Schinazi
Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine.
Journal of medicinal chemistry 1990;33(8):2188-92.
1990: Chung (David) K. Chu; G V Ullas; Lak Shin Jeong; S K Ahn; B Doboszewski; Z X Lin; J Warren Beach; Ray F Schinazi
Synthesis and structure-activity relationships of 6-substituted 2',3'-dideoxypurine nucleosides as potential anti-human immunodeficiency virus agents.
Journal of medicinal chemistry 1990;33(6):1553-61.
1990: Ray F Schinazi; Chung (David) K. Chu; J R Babu; B J Oswald; V Saalmann; D L Cannon; B F Eriksson; M Nasr
Anthraquinones as a new class of antiviral agents against human immunodeficiency virus.
Antiviral research 1990;13(5):265-72.
1990: B A Patel; F Douglas Boudinot; Ray F Schinazi; J M Gallo; Chung (David) K. Chu
Comparative pharmacokinetics and interspecies scaling of 3'-azido-3'-deoxythymidine (AZT) in several mammalian species.
Journal of pharmacobio-dynamics 1990;13(3):206-11.
1990: F Douglas Boudinot; Ray F Schinazi; J M Gallo; H M McClure; D C Anderson; K J Doshi; P C Kambhampathi; Chung (David) K. Chu
3'-Azido-2',3'-dideoxyuridine (AzddU): comparative pharmacokinetics with 3'-azido-3'-deoxythymidine (AZT) in monkeys.
AIDS research and human retroviruses 1990;6(2):219-28.
1990: R McCaffrey; R Duff; K Bulger; Z Spigelman; K Flora; Ray F Schinazi; Chung (David) K. Chu
Terminal transferase as a therapeutic target in leukemia cells.
Progress in clinical and biological research 1990;352():409-16.
1990: Ray F Schinazi; Chung (David) K. Chu; B F Eriksson; J P Sommadossi; K J Doshi; F Douglas Boudinot; B Oswald; H M McClure
Antiretroviral activity, biochemistry, and pharmacokinetics of 3'-azido-2',3'-dideoxy-5-methylcytidine.
Annals of the New York Academy of Sciences 1990;616():385-97.
1990: P Van Roey; E W Taylor; Chung (David) K. Chu; Ray F Schinazi
Correlation of molecular conformation and activity of reverse transcriptase inhibitors.
Annals of the New York Academy of Sciences 1990;616():29-40.
1989: K J Doshi; J M Gallo; F Douglas Boudinot; Ray F Schinazi; Chung (David) K. Chu
Comparative pharmacokinetics of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZddU) in mice.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(6):590-4.
1989: B F Eriksson; Chung (David) K. Chu; Ray F Schinazi
Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate.
Antimicrobial agents and chemotherapy 1989;33(10):1729-34.
1989: B A Patel; Chung (David) K. Chu; F Douglas Boudinot
Pharmacokinetics and saturable renal tubular secretion of zidovudine in rats.
Journal of pharmaceutical sciences 1989;78(7):530-4.
1989: P Van Roey; J M Salerno; Chung (David) K. Chu; Ray F Schinazi
Correlation between preferred sugar ring conformation and activity of nucleoside analogues against human immunodeficiency virus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):3929-33.
1989: Chung (David) K. Chu; Ray F Schinazi; M K Ahn; G V Ullas; Z P Gu
Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells.
Journal of medicinal chemistry 1989;32(3):612-7.
1989: Chung (David) K. Chu; J Matulic-Adamic; J T Huang; Ting-Chao Chou; J H Burchenal; J J Fox; KA Watanabe
Nucleosides. CXXXV. Synthesis of some 9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purines and their biological activities.
Chemical & pharmaceutical bulletin 1989;37(2):336-9.
1988: Chung (David) K. Chu; Ray F Schinazi; B H Arnold; D L Cannon; B Doboszewski; V B Bhadti; Z P Gu
Comparative activity of 2',3'-saturated and unsaturated pyrimidine and purine nucleosides against human immunodeficiency virus type 1 in peripheral blood mononuclear cells.
Biochemical pharmacology 1988;37(19):3543-8.
1988: T S Lin; J Y Guo; Ray F Schinazi; Chung (David) K. Chu; J N Xiang; W H Prusoff
Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV).
Journal of medicinal chemistry 1988;31(2):336-40.
1983: KA Watanabe; T L Su; R S Klein; Chung (David) K. Chu; A Matsuda; Moon Woo Chun; C Lopez; J J Fox
Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-beta-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationships.
Journal of medicinal chemistry 1983;26(2):152-6.
1982: J D Stoeckler; C A Bell; R E Parks; Chung (David) K. Chu; J J Fox; M Ikehara
C(2')-substituted purine nucleoside analogs. Interactions with adenosine deaminase and purine nucleoside phosphorylase and formation of analog nucleotides.
Biochemical pharmacology 1982;31(9):1723-8.
1980: KA Watanabe; U Reichman; Chung (David) K. Chu; D H Hollenberg; J J Fox
Nucleosides. 116. 1-(beta-D-Xylofuranosyl)-5-fluorocytosines with a leaving group on the 3' position. Potential double-barreled masked precursors of anticancer nucleosides.
Journal of medicinal chemistry 1980;23(10):1088-94.
1979: T C Chou; J H Burchenal; J J Fox; K A Watanabe; Chung (David) K. Chu; F S Philips
Metabolism and effects of 5-(beta-D-ribofuranosyl)isocytosine in P815 cells.
Cancer research 1979;39(3):720-8.
1977: Chung (David) K. Chu; T J Bardos
Synthesis and inhibition analysis of 2(4)-imino-4(2)-amino-2,4-dideoxyriboflavin, a dual antagonist of riboflavin and folinic acid.
Journal of medicinal chemistry 1977;20(2):312-4.
1976: U Reichman; D H Hollenberg; Chung (David) K. Chu; K A Watanabe; J J Fox
Nucleosides. 98. Direct introduction of an acetamido group into the sugar moiety of nucleoside epoxides.
The Journal of organic chemistry 1976;41(11):2042-3.
1976: J H Burchenal; K Ciovacco; K Kalaher; T O'Toole; R Kiefner; M D Dowling; Chung (David) K. Chu; K A Watanabe; I Wempen; J J Fox
Antileukemic effects of pseudoisocytidine, a new synthetic pyrimidine C-nucleoside.
Cancer research 1976;36(4):1520-3.