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Leo Hofland

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R van der Pas; Wouter W de Herder; Leo Hofland; Frank W G Leebeek; Richard A Feelders
Hypercoagulability in Cushing's syndrome: prevalence, pathogenesis and treatment.
Richard A Feelders; Sebastian J C M M Neggers; Aart Jan Van der Lely; Wouter W de Herder; Leo Hofland
Pasireotide, a multi-somatostatin receptor ligand with potential efficacy for treatment of pituitary and neuroendocrine tumors.
Richard A Feelders; Leo Hofland
Medical treatment of Cushing's disease.

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2013: R van der Pas; Wouter W de Herder; Leo Hofland; Frank W G Leebeek; Richard A Feelders
Hypercoagulability in Cushing's syndrome: prevalence, pathogenesis and treatment.
Clinical endocrinology 2013;78(4):481-8.
2013: Richard A Feelders; Sebastian J C M M Neggers; Aart Jan Van der Lely; Wouter W de Herder; Leo Hofland
Pasireotide, a multi-somatostatin receptor ligand with potential efficacy for treatment of pituitary and neuroendocrine tumors.
Drugs of today (Barcelona, Spain : 1998) 2013;49(2):89-103.
2013: Richard A Feelders; Leo Hofland
Medical treatment of Cushing's disease.
The Journal of clinical endocrinology and metabolism 2013;98(2):425-38.
2013: Aimee J Varewijck; Wilmar M Wiersinga; Steven W J Lamberts; Anita Boelen; Eric Fliers; Leo Hofland; Joop A M J L Janssen
Circulating IgGs may modulate IGF-I receptor stimulating activity in a subset of patients with Graves' ophthalmopathy.
The Journal of clinical endocrinology and metabolism 2013;98(2):769-76.
2013: Aimee J Varewijck; Leo Hofland; Steven W J Lamberts; Sebastian J C M M Neggers; Joop A M J L Janssen
IGF-I bioactivity might reflect different aspects of quality of life than total IGF-I in GH-deficient patients during GH treatment.
The Journal of clinical endocrinology and metabolism 2013;98(2):761-8.
2013: Federico Gatto; Wouter W de Herder; Richard A Feelders; Diego Ferone; Johan M Kros; Steven W J Lamberts; Francesco Minuto; Sebastian J C M M Neggers; Diana Sprij-Mooij; Aart-Jan van der Lelij; Rob van der Pas; Marlijn Waaijers; Leo Hofland
Immunoreactivity score using an anti-sst2A receptor monoclonal antibody strongly predicts the biochemical response to adjuvant treatment with somatostatin analogs in acromegaly.
The Journal of clinical endocrinology and metabolism 2013;98(1):E66-71.
2013: Jan Hofland; Leo Hofland; Anelia Horvath; Constantine A Stratakis; Peter M Van Koetsveld; Francien H van Nederveen; Wouter W de Herder; Frank H de Jong; Ronald R de Krijger; Lieke Derks; Richard A Feelders
Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome.
European journal of endocrinology / European Federation of Endocrine Societies 2013;168(1):67-74.
2012: R van der Pas; Peter M Van Koetsveld; Wiebke Arlt; Wouter W de Herder; F H de Jong; Jan Hofland; Leo Hofland; J Steenbergen; A E Taylor; Richard A Feelders
Fluconazole inhibits human adrenocortical steroidogenesis in vitro.
The Journal of endocrinology 2012;215(3):403-12.
2012: R van der Pas; Pierre M J Zelissen; C de Bruin; Wouter W de Herder; Frank de Jong; M P M de Maat; Ad R M M Hermus; Leo Hofland; S W J Lamberts; F W G Leebeek; R T Netea-Maier; A M Pereira; Dingeman C Rijken; Johannes A Romijn; A J van der Lely; Richard A Feelders
The hypercoagulable state in Cushing's disease is associated with increased levels of procoagulant factors and impaired fibrinolysis, but is not reversible after short-term biochemical remission induced by medical therapy.
The Journal of clinical endocrinology and metabolism 2012;97(4):1303-10.
2012: C de Bruin; Wouter W de Herder; Leo Hofland; S W J Lamberts; L K Nieman; D M Sprij-Mooij; Martijn van Essen; P M van Koetsveld; A M Waaijers; Richard A Feelders
Mifepristone effects on tumor somatostatin receptor expression in two patients with Cushing's syndrome due to ectopic adrenocorticotropin secretion.
The Journal of clinical endocrinology and metabolism 2012;97(2):455-62.
2012: R van der Pas; Leo Hofland; Wouter W de Herder; Richard A Feelders
New developments in the medical treatment of Cushing's syndrome.
Endocrine-related cancer 2012;19(6):R205-23.
2011: A J Varewijck; Leo Hofland; S W J Lamberts; Piet Uitterlinden; J A M J L Janssen
IGF-I bioactivity better reflects growth hormone deficiency than total IGF-I.
The Journal of clinical endocrinology and metabolism 2011;96(7):2248-54.
2010: Patric J D Delhanty; Anke van Kerkwijk; Martin Huisman; Bedette van de Zande; Miriam Verhoef-Post; Carlotta Gauna; Leo Hofland; Axel P N Themmen; Aart Jan Van der Lely
Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization.
American journal of physiology. Endocrinology and metabolism 2010;299(3):E497-505.
2010: J W B de Groot; T P Links; Axel P N Themmen; Leendert H J Looijenga; Ronald R de Krijger; Peter M Van Koetsveld; Jan Hofland; G van den Berg; Leo Hofland; Richard A Feelders
Aberrant expression of multiple hormone receptors in ACTH-independent macronodular adrenal hyperplasia causing Cushing's syndrome.
European journal of endocrinology / European Federation of Endocrine Societies 2010;163(2):293-9.
2010: M C De Martino; Peter M Van Koetsveld; Rosario Pivonello; Leo Hofland
Role of the mTOR pathway in normal and tumoral adrenal cells.
Neuroendocrinology 2010;92 Suppl 1():28-34.
2009: Michele Caraglia; Monica Marra; Pierosandro Tagliaferri; S W J Lamberts; S Zappavigna; G Misso; Francesco Cavagnini; G Facchini; Alberto Abbruzzese; Leo Hofland; Giovanni Vitale
Emerging strategies to strengthen the anti-tumour activity of type I interferons: overcoming survival pathways.
Current cancer drug targets 2009;9(5):690-704.
2009: C de Bruin; Richard A Feelders; S W J Lamberts; Leo Hofland
Somatostatin and dopamine receptors as targets for medical treatment of Cushing's Syndrome.
Reviews in endocrine & metabolic disorders 2009;10(2):91-102.
2009: Christiaan de Bruin; Alberto M Pereira; Richard A Feelders; Johannes A Romijn; Ferdinand Roelfsema; Diane M Sprij-Mooij; Maarten O van Aken; Aart-Jan van der Lelij; Wouter W de Herder; Steven W J Lamberts; Leo Hofland
Coexpression of dopamine and somatostatin receptor subtypes in corticotroph adenomas.
The Journal of clinical endocrinology and metabolism 2009;94(4):1118-24.
2009: C de Bruin; R A Feelders; A M Waaijers; P M van Koetsveld; D M Sprij-Mooij; S W J Lamberts; Leo Hofland
Differential regulation of human dopamine D2 and somatostatin receptor subtype expression by glucocorticoids in vitro.
Journal of molecular endocrinology 2009;42(1):47-56.
2008: B M K Biller; A B Grossman; P M Stewart; S Melmed; X Bertagna; J Bertherat; M Buchfelder; A Colao; A R Hermus; Leo Hofland; A Klibanski; A Lacroix; John Lindsay; J Newell-Price; L K Nieman; S Petersenn; N Sonino; G K Stalla; B Swearingen; M L Vance; J A H Wass; M Boscaro
Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement.
The Journal of clinical endocrinology and metabolism 2008;93(7):2454-62.
2007: Y M H Jonkers; S M H Claessen; Aurel Perren; Anja M Schmitt; Leo Hofland; W de Herder; Ronald R de Krijger; Albert A J Verhofstad; A R Hermus; J A Kummer; B Skogseid; M Volante; A C Voogd; Frans C S Ramaekers; Ernst J M Speel
DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients.
Endocrine-related cancer 2007;14(3):769-79.
2007: Monica Fedele; Ivana De Martino; Rosario Pivonello; Andrea Ciarmiello; M Laura Del Basso De Caro; Rosa Visone; Dario Palmieri; Giovanna Maria Pierantoni; Claudio Arra; Herbert A Schmid; Leo Hofland; Gaetano Lombardi; Annamaria Colao; Alfredo Fusco
SOM230, a new somatostatin analogue, is highly effective in the therapy of growth hormone/prolactin-secreting pituitary adenomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(9):2738-44.
2005: Y M H Jonkers; S M H Claessen; Aurel Perren; Sonja Schmid; Paul Komminoth; Albert A J Verhofstad; Leo Hofland; Ronald R de Krijger; P J Slootweg; Frans C S Ramaekers; Ernst J M Speel
Chromosomal instability predicts metastatic disease in patients with insulinomas.
Endocrine-related cancer 2005;12(2):435-47.
2004: S A Bovenberg; G F F M Pieters; Leo Hofland; Ad R M M Hermus
Leuprolide acetate therapy in LH-dependent Cushing's syndrome: in vivo and in vitro observations.
The Netherlands journal of medicine 2004;62(11):456-8.
2004: A Mosca; L Dogliotti; Alfredo Berruti; Steven W J Lamberts; Leo Hofland
Somatostatin receptors: from basic science to clinical approach. Unlabeled somatostatin analogues-1: Prostate cancer.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2004;36 Suppl 1():S60-7.
2000: R J Croughs; Pierre M J Zelissen; Th J M V van Vroonhoven; Leo Hofland; Nina N'Diaye; André Lacroix; W W de Herder
GIP-dependent adrenal Cushing's syndrome with incomplete suppression of ACTH.
Clinical endocrinology 2000;52(2):235-40.
1999: Wouter A P Breeman; Marion De Jong; Bert F Bernard; Dik J Kwekkeboom; Ananth Srinivasan; ME van der Pluijm; Leo Hofland; Theo J Visser; Eric P Krenning
Pre-clinical evaluation of [(111)In-DTPA-Pro(1), Tyr(4)]bombesin, a new radioligand for bombesin-receptor scintigraphy.
International journal of cancer. Journal international du cancer 1999;83(5):657-63.
1999: Annick Van den Bruel; J Fevery; J Van Dorpe; Leo Hofland; Roger Bouillon
Hormonal and volumetric long term control of a growth hormone-releasing hormone-producing carcinoid tumor.
The Journal of clinical endocrinology and metabolism 1999;84(9):3162-9.
1999: Wouter A P Breeman; Leo Hofland; Marion De Jong; Bert F Bernard; Ananth Srinivasan; Dik J Kwekkeboom; Theo J Visser; Eric P Krenning
Evaluation of radiolabelled bombesin analogues for receptor-targeted scintigraphy and radiotherapy.
International journal of cancer. Journal international du cancer 1999;81(4):658-65.
1998: A M Alings; Eric Fliers; W W de Herder; Leo Hofland; H E Sluiter; Thera P Links; Johannes H Van Der Hoeven; Wilmar M Wiersinga
A thyrotropin-secreting pituitary adenoma as a cause of thyrotoxic periodic paralysis.
Journal of endocrinological investigation 1998;21(10):703-6.
1998: Marion De Jong; Wouter A P Breeman; Willem H Bakker; Peter P M Kooij; Bert F Bernard; Leo Hofland; Theo J Visser; Ananth Srinivasan; Michelle A Schmidt; Jack Erion; Joseph E Bugaj; Helmut R Mäcke; Eric P Krenning
Comparison of (111)In-labeled somatostatin analogues for tumor scintigraphy and radionuclide therapy.
Cancer research 1998;58(3):437-41.
1998: Marion De Jong; Willem H Bakker; Wouter A P Breeman; Bert F Bernard; Leo Hofland; Theo J Visser; Ananth Srinivasan; Michelle Schmidt; Martin Béhé; Helmut R Mäcke; Eric P Krenning
Pre-clinical comparison of [DTPA0] octreotide, [DTPA0,Tyr3] octreotide and [DOTA0,Tyr3] octreotide as carriers for somatostatin receptor-targeted scintigraphy and radionuclide therapy.
International journal of cancer. Journal international du cancer 1998;75(3):406-11.
1998: Wouter A P Breeman; Marion De Jong; B Bernard; Leo Hofland; Ananth Srinivasan; ME van der Pluijm; Willem H Bakker; Theo J Visser; Eric P Krenning
Tissue distribution and metabolism of radioiodinated DTPA0, D-Tyr1 and Tyr3 derivatives of octreotide in rats.
Anticancer research 1998;18(1A):83-9.
1997: Leo Hofland; Steven W J Lamberts
Somatostatin analogs and receptors. Diagnostic and therapeutic applications.
Cancer treatment and research 1997;89():365-82.
1996: Wouter W de Herder; Leo Hofland; A J van der Lely; Steven W J Lamberts
Peptide receptors in gut endocrine tumours.
Baillière's clinical gastroenterology 1996;10(4):571-87.
1996: Wouter W de Herder; Ambroos E M Reijs; Dik J Kwekkeboom; Leo Hofland; FR Nobels; H Y Oei; Eric P Krenning; Steven W J Lamberts
In vivo imaging of pituitary tumours using a radiolabelled dopamine D2 receptor radioligand.
Clinical endocrinology 1996;45(6):755-67.
1996: Wouter A P Breeman; Willem H Bakker; Marion De Jong; Leo Hofland; Dik J Kwekkeboom; Peter P M Kooij; Theo J Visser; Eric P Krenning
Studies on radiolabeled somatostatin analogues in rats and in patients.
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 1996;40(3):209-20.
1996: Wouter W de Herder; Leo Hofland; t usdin; Frank de Jong; Piet Uitterlinden; Peter M Van Koetsveld; Eva Mezey; Tom Bonner; H J Bonjer; Steven W J Lamberts
Food-dependent Cushing's syndrome resulting from abundant expression of gastric inhibitory polypeptide receptors in adrenal adenoma cells.
The Journal of clinical endocrinology and metabolism 1996;81(9):3168-72.
1996: Steven W J Lamberts; A J van der Lely; Wouter W de Herder; Leo Hofland
Somatostatin analogs: future directions.
Metabolism: clinical and experimental 1996;45(8 Suppl 1):104-6.
1996: A J van der Lely; Wouter W de Herder; Leo Hofland; S W Lamberts
[Prolactinoma; diagnosis and treatment].
Nederlands tijdschrift voor geneeskunde 1996;140(28):1445-9.
1996: A J van der Lely; Wouter W de Herder; Leo Hofland; S W Lamberts
[Acromegaly; diagnosis and treatment].
Nederlands tijdschrift voor geneeskunde 1996;140(28):1436-40.
1996: Steven W J Lamberts; A J van der Lely; Wouter W de Herder; Leo Hofland
Octreotide.
The New England journal of medicine 1996;334(4):246-54.
1996: H A Visser-Wisselaar; Leo Hofland; C J van Uffelen; Peter M Van Koetsveld; Steven W J Lamberts
Somatostatin receptor manipulation.
Digestion 1996;57 Suppl 1():7-10.
1996: Leo Hofland; Peter M Van Koetsveld; Marlijn Waaijers; Steven W J Lamberts
Internalisation of isotope-coupled somatostatin analogues.
Digestion 1996;57 Suppl 1():2-6.
1996: Leo Hofland; Steven W J Lamberts
Somatostatin receptors and disease: role of receptor subtypes.
Baillière's clinical endocrinology and metabolism 1996;10(1):163-76.
1995: Wouter W de Herder; A J van der Lely; Joop A M J L Janssen; Piet Uitterlinden; Leo Hofland; Steven W J Lamberts
IGFBP-3 is a poor parameter for assessment of clinical activity in acromegaly.
Clinical endocrinology 1995;43(4):501-5.
1995: Leo Hofland; Peter M Van Koetsveld; Marlijn Waaijers; J Zuyderwijk; Wouter A P Breeman; Steven W J Lamberts
Internalization of the radioiodinated somatostatin analog [125I-Tyr3]octreotide by mouse and human pituitary tumor cells: increase by unlabeled octreotide.
Endocrinology 1995;136(9):3698-706.
1995: Jan Rondeel; Willem Klootwijk; E Linkels; P H Jeucken; W Allaerts; Leo Hofland; Maria E Everts; Piet Kramer; Frank de Jong; G A van Haasteren
Further studies on the regulation, localization and function of the TRH-like peptide pyroglutamyl-glutamyl-prolineamide in the rat anterior pituitary gland.
The Journal of endocrinology 1995;146(2):293-300.
1995: Wouter W de Herder; Piet Uitterlinden; A J van der Lely; Leo Hofland; Steven W J Lamberts
Octreotide, but not bromocriptine, increases circulating insulin-like growth factor binding protein 1 levels in acromegaly.
European journal of endocrinology / European Federation of Endocrine Societies 1995;133(2):195-9.
1995: Leo Hofland; H A Visser-Wisselaar; Steven W J Lamberts
Somatostatin analogs: clinical application in relation to human somatostatin receptor subtypes.
Biochemical pharmacology 1995;50(3):287-97.
1995: Marion De Jong; Wouter A P Breeman; Bert F Bernard; Edgar J Rolleman; Leo Hofland; Theo J Visser; B Setyono-Han; Willem H Bakker; ME van der Pluijm; Eric P Krenning
Evaluation in vitro and in rats of 161Tb-DTPA-octreotide, a somatostatin analogue with potential for intraoperative scanning and radiotherapy.
European journal of nuclear medicine 1995;22(7):608-16.
1995: Wouter A P Breeman; Dik J Kwekkeboom; Peter P M Kooij; Willem H Bakker; Leo Hofland; Theo J Visser; G J Ensing; Steven W J Lamberts; Eric P Krenning
Effect of dose and specific activity on tissue distribution of indium-111-pentetreotide in rats.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(4):623-7.
1995: Leo Hofland; Bart van der Burg; C H J van Eijck; D M Sprij; Peter M Van Koetsveld; Steven W J Lamberts
Role of tumor-derived fibroblasts in the growth of primary cultures of human breast-cancer cells: effects of epidermal growth factor and the somatostatin analogue octreotide.
International journal of cancer. Journal international du cancer 1995;60(1):93-9.
1995: Steven W J Lamberts; Wouter W de Herder; Peter M Van Koetsveld; Jan W Koper; A J van der Lely; H A Visser-Wisselaar; Leo Hofland
Somatostatin receptors: clinical implications for endocrinology and oncology.
Ciba Foundation symposium 1995;190():222-36; discussion 236-9.
1994: C H J van Eijck; Gerrit D Slooter; Leo Hofland; W Kort; Johannes Jeekel; S W Lamberts; Richard L Marquet
Somatostatin receptor-dependent growth inhibition of liver metastases by octreotide.
The British journal of surgery 1994;81(9):1333-7.
1994: Wouter W de Herder; Eric P Krenning; C D Malchoff; Leo Hofland; J C Reubi; Dik J Kwekkeboom; H Y Oei; H A Pols; Hajo A Bruining; FR Nobels
Somatostatin receptor scintigraphy: its value in tumor localization in patients with Cushing's syndrome caused by ectopic corticotropin or corticotropin-releasing hormone secretion.
The American journal of medicine 1994;96(4):305-12.
1994: Wouter A P Breeman; Leo Hofland; ME van der Pluijm; Peter M Van Koetsveld; Marion De Jong; B Setyono-Han; Willem H Bakker; Dik J Kwekkeboom; Theo J Visser; Steven W J Lamberts
A new radiolabelled somatostatin analogue [111In-DTPA-D-Phe1]RC-160: preparation, biological activity, receptor scintigraphy in rats and comparison with [111In-DTPA-D-Phe1]octreotide.
European journal of nuclear medicine 1994;21(4):328-35.
1994: Leo Hofland; Peter M Van Koetsveld; Marlijn Waaijers; J Zuyderwijk; Steven W J Lamberts
Relative potencies of the somatostatin analogs octreotide, BIM-23014, and RC-160 on the inhibition of hormone release by cultured human endocrine tumor cells and normal rat anterior pituitary cells.
Endocrinology 1994;134(1):301-6.
1993: Wouter A P Breeman; Leo Hofland; Willem H Bakker; ME van der Pluijm; Peter M Van Koetsveld; Marion De Jong; B Setyono-Han; Dik J Kwekkeboom; Theo J Visser; Steven W J Lamberts
Radioiodinated somatostatin analogue RC-160: preparation, biological activity, in vivo application in rats and comparison with [123I-Tyr3]octreotide.
European journal of nuclear medicine 1993;20(11):1089-94.
1993: Dik J Kwekkeboom; J Assies; Leo Hofland; J C Reubi; Steven W J Lamberts; Eric P Krenning
A case of antibody formation against octreotide visualized with 111In-octreotide scintigraphy.
Clinical endocrinology 1993;39(2):239-43; discussion 244.
1993: J Assies; Nicolaas P L G Verhoeff; D A Bosch; Leo Hofland
Intracranial dissemination of a macroprolactinoma.
Clinical endocrinology 1993;38(5):539-46.
1993: Maria E Everts; Roel Docter; J C van Buuren; Peter M Van Koetsveld; Leo Hofland; Marion De Jong; Eric P Krenning; Georg Hennemann
Evidence for carrier-mediated uptake of triiodothyronine in cultured anterior pituitary cells of euthyroid rats.
Endocrinology 1993;132(3):1278-85.
1993: Steven W J Lamberts; Leo Hofland; Wouter W de Herder; Dik J Kwekkeboom; J C Reubi; Eric P Krenning
Octreotide and related somatostatin analogs in the diagnosis and treatment of pituitary disease and somatostatin receptor scintigraphy.
Frontiers in neuroendocrinology 1993;14(1):27-55.
1992: Leo Hofland; Brigitte Velkeniers; A J vd Lely; Peter M Van Koetsveld; M Kazemzadeh; Marlijn Waaijers; Elisabeth L Hooghe-Peters; Steven W J Lamberts
Long-term in-vitro treatment of human growth hormone (GH)-secreting pituitary adenoma cells with octreotide causes accumulation of intracellular GH and GH mRNA levels.
Clinical endocrinology 1992;37(3):240-8.
1992: Leo Hofland; Peter M Van Koetsveld; N Wouters; Marlijn Waaijers; J C Reubi; Steven W J Lamberts
Dissociation of antiproliferative and antihormonal effects of the somatostatin analog octreotide on 7315b pituitary tumor cells.
Endocrinology 1992;131(2):571-7.
1991: Steven W J Lamberts; Peter M Van Koetsveld; Leo Hofland
The interrelationship between the anti-mitotic action of the somatostatin analog octreotide and that of cytostatic drugs and suramin.
International journal of cancer. Journal international du cancer 1991;48(6):938-41.
1991: Leo Hofland; Brigitte Velkeniers; Peter M Van Koetsveld; Elisabeth L Hooghe-Peters; Steven W J Lamberts
The relationship between growth hormone (GH) messenger ribonucleic acid levels and hormone release from individual cells derived from human GH-secreting pituitary adenomas.
Clinical endocrinology 1991;34(1):5-11.
1991: W Allaerts; P H Jeucken; Leo Hofland; Hemmo Drexhage
Morphological, immunohistochemical and functional homologies between pituitary folliculo-stellate cells and lymphoid dendritic cells.
Acta endocrinologica 1991;125 Suppl 1():92-7.
1991: Willem H Bakker; Rainer Albert; Christian Bruns; Wouter A P Breeman; Leo Hofland; P Marbach; Janos Pless; D Pralet; Barbara Stolz; Jan W Koper
[111In-DTPA-D-Phe1]-octreotide, a potential radiopharmaceutical for imaging of somatostatin receptor-positive tumors: synthesis, radiolabeling and in vitro validation.
Life sciences 1991;49(22):1583-91.
1990: Jan W Koper; Leo Hofland; Peter M Van Koetsveld; F den Holder; Steven W J Lamberts
Desensitization and resensitization of rat pituitary tumor cells in long-term culture to the effects of the somatostatin analogue SMS 201-995 on cell growth and prolactin secretion.
Cancer research 1990;50(19):6238-42.
1990: Dik J Kwekkeboom; Leo Hofland; Peter M Van Koetsveld; R Singh; J H van den Berge; Steven W J Lamberts
Bromocriptine increasingly suppresses the in vitro gonadotropin and alpha-subunit release from pituitary adenomas during long term culture.
The Journal of clinical endocrinology and metabolism 1990;71(3):718-24.
1990: Steven W J Lamberts; Leo Hofland; Peter M Van Koetsveld; J C Reubi; Hajo A Bruining; Willem H Bakker; Eric P Krenning
Parallel in vivo and in vitro detection of functional somatostatin receptors in human endocrine pancreatic tumors: consequences with regard to diagnosis, localization, and therapy.
The Journal of clinical endocrinology and metabolism 1990;71(3):566-74.
1990: H F Marzouk; Leo Hofland; F H den Holder; Peter M Van Koetsveld; J Steenbergen; J Zuiderwijk; E M Abou-Hashim; M H el-Kannishy; Frank de Jong; Steven W J Lamberts
Effects of suramin on hormone release by cultured rat anterior pituitary cells.
Molecular and cellular endocrinology 1990;72(2):95-102.
1990: A Binnerts; Piet Uitterlinden; Leo Hofland; Peter M Van Koetsveld; Steven W J Lamberts
The in vitro and in vivo effects of human growth hormone administration on tumor growth of rats bearing a transplantable rat pituitary tumor (7315b).
European journal of cancer (Oxford, England : 1990) 1990;26(3):269-76.
1990: Steven W J Lamberts; Peter M Van Koetsveld; Leo Hofland
The effect of clozapine on prolactin secretion at the level of the lactotroph.
Life sciences 1990;46(14):1013-9.
1990: Leo Hofland; Peter M Van Koetsveld; Steven W J Lamberts
Percoll density gradient centrifugation of rat pituitary tumor cells: a study of functional heterogeneity within and between tumors with respect to growth rates, prolactin production and responsiveness to the somatostatin analog SMS 201-995.
European journal of cancer (Oxford, England : 1990) 1990;26(1):37-44.
1990: Leo Hofland; Peter M Van Koetsveld; T M Verleun; Steven W J Lamberts
Long-term culture of rat mammotrope and somatotrope subpopulations separated on continuous Percoll density gradients: effects of dopamine, TRH, GHRH and somatostatin.
Acta endocrinologica 1990;122(1):127-36.
1989: Steven W J Lamberts; Peter M Van Koetsveld; Leo Hofland
A close correlation between the inhibitory effects of insulin-like growth factor-I and SMS 201-995 on growth hormone release by acromegalic pituitary tumours in vitro and in vivo.
Clinical endocrinology 1989;31(4):401-10.
1989: Leo Hofland; Peter M Van Koetsveld; T M Verleun; Steven W J Lamberts
Heterogeneity of pituitary adenoma cell subpopulations from acromegalic patients obtained by Percoll density gradient centrifugation.
Acta endocrinologica 1989;121(2):270-8.
1989: Steven W J Lamberts; J Zuyderwijk; F den Holder; Peter M Van Koetsveld; Leo Hofland
Studies on the conditions determining the inhibitory effect of somatostatin on adrenocorticotropin, prolactin and thyrotropin release by cultured rat pituitary cells.
Neuroendocrinology 1989;50(1):44-50.
1989: Leo Hofland; Peter M Van Koetsveld; T M Verleun; Steven W J Lamberts
Glycoprotein hormone alpha-subunit and prolactin release by cultured pituitary adenoma cells from acromegalic patients: correlation with GH release.
Clinical endocrinology 1989;30(6):601-11.
1989: Leo Hofland; Peter M Van Koetsveld; C C van Vroonhoven; S Z Stefanko; Steven W J Lamberts
Heterogeneity of growth hormone (GH) release by individual pituitary adenoma cells from acromegalic patients, as determined by the reverse hemolytic plaque assay: effects of SMS 201-995, GH-releasing hormone and thyrotropin-releasing hormone.
The Journal of clinical endocrinology and metabolism 1989;68(3):613-20.
1989: Steven W J Lamberts; F den Holder; Leo Hofland
The interrelationship between the effects of insulin-like growth factor I and somatostatin on growth hormone secretion by normal rat pituitary cells: the role of glucocorticoids.
Endocrinology 1989;124(2):905-11.
1987: Leo Hofland; Peter M Van Koetsveld; Jan W Koper; A den Holder; Steven W J Lamberts
Weak estrogenic activity of phenol red in the culture medium: its role in the study of the regulation of prolactin release in vitro.
Molecular and cellular endocrinology 1987;54(1):43-50.
1987: Steven W J Lamberts; T Verleun; Leo Hofland; E Del Pozo
A comparison between the effects of SMS 201-995, bromocriptine and a combination of both drugs on hormone release by the cultured pituitary tumour cells of acromegalic patients.
Clinical endocrinology 1987;27(1):11-23.
1987: Steven W J Lamberts; T Verleun; R Oosterom; Leo Hofland; Leendert A van Ginkel; Gerard LOEBER; C C van Vroonhoven; S Z Stefanko; Frank de Jong
The effects of bromocriptine, thyrotropin-releasing hormone, and gonadotropin-releasing hormone on hormone secretion by gonadotropin-secreting pituitary adenomas in vivo and in vitro.
The Journal of clinical endocrinology and metabolism 1987;64(3):524-30.
1986: S W Lamberts; T Verleun; Leo Hofland; R Oosterom
Differences in the interaction between dopamine and estradiol on prolactin release by cultured normal and tumorous human pituitary cells.
The Journal of clinical endocrinology and metabolism 1986;63(6):1342-7.
1986: A C van Dinther-Janssen; Leo Hofland; R J Scheper
Specific plasma cell accumulation in antigen-induced chronic inflammation in the guinea pig peritoneal cavity.
International archives of allergy and applied immunology 1986;79(1):14-8.
1983: N van Rooijen; Leo Hofland; C D Dijkstra
The effectiveness of 3H-uridine and 3H-leucine for labeling of T and B cells of rats and mice.
Immunological communications 1983;12(3):331-5.