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Michel Klein

Research Profile

Living Beings

Anatomy

T-Lymphocytes, Cytotoxic

Disorders

Chemicals & Drugs

Physiology

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May Young Lin; T B K Reddy; Sandra M Arend; Annemieke H Friggen; Kees L M C Franken; Krista E van Meijgaarden; Marleen J C Verduyn; Gary K Schoolnik; Michel Klein; Tom H M Ottenhoff
Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria.
I L Bartek; R Rutherford; V Gruppo; R A Morton; R P Morris; Michel Klein; Kevin C Visconti; G J Ryan; Gary K Schoolnik; A Lenaerts; Martin I Voskuil
The DosR regulon of M. tuberculosis and antibacterial tolerance.
Tjeerd G Kimman; Eric Smit; Michel Klein
Evidence-based biosafety: a review of the principles and effectiveness of microbiological containment measures.

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All Publications

2009: May Young Lin; T B K Reddy; Sandra M Arend; Annemieke H Friggen; Kees L M C Franken; Krista E van Meijgaarden; Marleen J C Verduyn; Gary K Schoolnik; Michel Klein; Tom H M Ottenhoff
Cross-reactive immunity to Mycobacterium tuberculosis DosR regulon-encoded antigens in individuals infected with environmental, nontuberculous mycobacteria.
Infection and immunity 2009;77(11):5071-9.
2009: I L Bartek; R Rutherford; V Gruppo; R A Morton; R P Morris; Michel Klein; Kevin C Visconti; G J Ryan; Gary K Schoolnik; A Lenaerts; Martin I Voskuil
The DosR regulon of M. tuberculosis and antibacterial tolerance.
Tuberculosis (Edinburgh, Scotland) 2009;89(4):310-6.
2008: Tjeerd G Kimman; Eric Smit; Michel Klein
Evidence-based biosafety: a review of the principles and effectiveness of microbiological containment measures.
Clinical microbiology reviews 2008;21(3):403-25.
2008: Ryan W Honaker; Amanda Stewart; Stephanie Schittone; Angelo Izzo; Michel Klein; Martin I Voskuil
Mycobacterium bovis BCG vaccine strains lack narK2 and narX induction and exhibit altered phenotypes during dormancy.
Infection and immunity 2008;76(6):2587-93.
2008: Abdulrahman Hammond; Samuel J McConkey; Philip C Hill; Sarah Crozier; Michel Klein; Richard A Adegbola; Sarah Rowland-Jones; Roger H Brookes; Hilton Whittle; Assan Jaye
Mycobacterial T cell responses in HIV-infected patients with advanced immunosuppression.
The Journal of infectious diseases 2008;197(2):295-9.
2007: May Young Lin; Annemieke Geluk; Steven G Smith; Amanda L Stewart; Annemieke H Friggen; Kees L M C Franken; Marleen J C Verduyn; Krista E van Meijgaarden; Martin I Voskuil; Hazel M Dockrell; Kris Huygen; Tom H M Ottenhoff; Michel Klein
Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination.
Infection and immunity 2007;75(7):3523-30.
2007: Edhyana Sahiratmadja; Alisjahbana Bachti; Simona Buccheri; Diana Di Liberto; Tjitske de Boer; Iskandar Adnan; Reinout van Crevel; Michel Klein; Krista E van Meijgaarden; R H H Nelwan; Esther van de Vosse; Francesco Dieli; Tom H M Ottenhoff
Plasma granulysin levels and cellular interferon-gamma production correlate with curative host responses in tuberculosis, while plasma interferon-gamma levels correlate with tuberculosis disease activity in adults.
Tuberculosis (Edinburgh, Scotland) 2007;87(4):312-21.
2007: Annemieke Geluk; May Young Lin; Krista E van Meijgaarden; Eliane M S Leyten; Kees L M C Franken; Tom H M Ottenhoff; Michel Klein
T-cell recognition of the HspX protein of Mycobacterium tuberculosis correlates with latent M. tuberculosis infection but not with M. bovis BCG vaccination.
Infection and immunity 2007;75(6):2914-21.
2007: Simone A Joosten; Krista E van Meijgaarden; Nigel D L Savage; Tjitske de Boer; Frédéric Triebel; Annemieke van der Wal; Emile de Heer; Michel Klein; Annemieke Geluk; Tom H M Ottenhoff
Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):8029-34.
2007: Virginie Roupie; Marta Romano; Lei Zhang; Hannelie Korf; May Young Lin; Kees L M C Franken; Tom H M Ottenhoff; Michel Klein; Kris Huygen
Immunogenicity of eight dormancy regulon-encoded proteins of Mycobacterium tuberculosis in DNA-vaccinated and tuberculosis-infected mice.
Infection and immunity 2007;75(2):941-9.
2006: Eliane M S Leyten; May Young Lin; Kees L M C Franken; Annemieke H Friggen; Corine Prins; Krista E van Meijgaarden; Martin I Voskuil; Karin Weldingh; Peter Andersen; Gary K Schoolnik; Sandra M Arend; Tom H M Ottenhoff; Michel Klein
Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis.
Microbes and infection / Institut Pasteur 2006;8(8):2052-60.
2006: Abebech Demissie; Eliane M S Leyten; Markos Abebe; Liya Wassie; Abraham Aseffa; Getahun Abate; Helen Fletcher; Patrick K Owiafe; Philip C Hill; Roger H Brookes; Graham Rook; Alimuddin Zumla; Sandra M Arend; Michel Klein; Tom H M Ottenhoff; Peter Andersen; T Mark Doherty
Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis.
Clinical and vaccine immunology : CVI 2006;13(2):179-86.
2006: Clarice Abramo; Krista E Meijgaarden; Daniely Garcia; Kees L M C Franken; Michel Klein; Arend J Kolk; Sergio C Oliveira; Tom H M Ottenhoff; Henrique C Teixeira
Monokine induced by interferon gamma and IFN-gamma response to a fusion protein of Mycobacterium tuberculosis ESAT-6 and CFP-10 in Brazilian tuberculosis patients.
Microbes and infection / Institut Pasteur 2006;8(1):45-51.
2005: Tom H M Ottenhoff; Michel Klein
Leprosy bacillus triggers the wrong cells.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association 2005;73(3):208-10.
2005: Annemieke Geluk; Michel Klein; Kees L M C Franken; Krista E van Meijgaarden; Brigitte Wieles; Kelly Pereira; Samira Bührer-Sékula; Paul R Klatser; Patrick J Brennan; John S Spencer; Diana L Williams; Maria Cristina Vidal Pessolani; Elizabeth P Sampaio; Tom H M Ottenhoff
Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection.
Infection and immunity 2005;73(9):5636-44.
2005: Philip C Hill; Dolly Jackson-Sillah; Annette Fox; Kees L M C Franken; Moses D Lugos; David J Jeffries; Simon A Donkor; Abdulrahman Hammond; Richard A Adegbola; Tom H M Ottenhoff; Michel Klein; Roger H Brookes
ESAT-6/CFP-10 fusion protein and peptides for optimal diagnosis of mycobacterium tuberculosis infection by ex vivo enzyme-linked immunospot assay in the Gambia.
Journal of clinical microbiology 2005;43(5):2070-4.
2005: Abdulrahman Hammond; Michel Klein; Tumani Corrah; Annette Fox; Assan Jaye; Keith P W J McAdam; Roger H Brookes
Mycobacterium tuberculosis genome-wide screen exposes multiple CD8 T cell epitopes.
Clinical and experimental immunology 2005;140(1):109-16.
2003: Assan Jaye; Cecile Van Els; Sabelle Jallow; Sowsan Atabani; Michel Klein; Peter Hoogerhout; Michael Kidd; Cécile A C M van Els; Hilton C Whittle
Vigorous but short-term gamma interferon T-cell responses against a dominant HLA-A*02-restricted measles virus epitope in patients with measles.
Journal of virology 2003;77(8):5014-6.
2002: Michel Klein; Abdulrahman Hammond; Steve M Smith; Assan Jaye; Pauline T Lukey; Keith P W J McAdam
HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.
Infection and immunity 2002;70(2):981-4.
2002: Steve M Smith; Michel Klein; AS Malin; Jackson Sillah; Keith P W J McAdam; Hazel M Dockrell
Decreased IFN- gamma and increased IL-4 production by human CD8(+) T cells in response to Mycobacterium tuberculosis in tuberculosis patients.
Tuberculosis (Edinburgh, Scotland) 2002;82(1):7-13.
2001: Michel Klein; Steve M Smith; Abdulrahman Hammond; Graham S Ogg; Abigail S Bailey; J Vekemans; Assan Jaye; Pauline T Lukey; Keith P W J McAdam
HLA-B*35-restricted CD8 T cell epitopes in the antigen 85 complex of Mycobacterium tuberculosis.
The Journal of infectious diseases 2001;183(6):928-34.
2001: Stefan Kostense; Graham S Ogg; Erik H Manting; G Gillespie; Jeanine Joling; Kristin Vandenberghe; E Z Veenhof; Debbie Van Baarle; Suzanne Jurriaans; Michel Klein; Frank Miedema
High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function.
European journal of immunology 2001;31(3):677-86.
2001: Michel Klein; A Fox
Mycobacterium-specific human CD8 T cell responses.
Archivum immunologiae et therapiae experimentalis 2001;49(5):379-89.
2000: Steve M Smith; Roger H Brookes; Michel Klein; AS Malin; Pauline T Lukey; Abigail S Bailey; Graham S Ogg; Adrian V S Hill; Hazel M Dockrell
Human CD8+ CTL specific for the mycobacterial major secreted antigen 85A.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7088-95.
2000: Steve M Smith; Michel Klein; AS Malin; Jackson Sillah; K Huygen; P Andersen; Keith P W J McAdam; Hazel M Dockrell
Human CD8(+) T cells specific for Mycobacterium tuberculosis secreted antigens in tuberculosis patients and healthy BCG-vaccinated controls in The Gambia.
Infection and immunity 2000;68(12):7144-8.
1999: Graham S Ogg; Stefan Kostense; Michel Klein; Suzanne Jurriaans; Dörte Hamann; Andrew J McMichael; Frank Miedema
Longitudinal phenotypic analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes: correlation with disease progression.
Journal of virology 1999;73(11):9153-60.
1999: Marcel G H M Beld; Maarten Penning; M van Putten; A van den Hoek; M Damen; Michel Klein; Jaap Goudsmit
Low levels of hepatitis C virus RNA in serum, plasma, and peripheral blood mononuclear cells of injecting drug users during long antibody-undetectable periods before seroconversion.
Blood 1999;94(4):1183-91.
1999: IP Keet; Jianming "James" Tang; Michel Klein; Susan LeBlanc; C Enger; Charles A Rivers; Raymond Apple; Dean L Mann; J J Goedert; Frank Miedema; Richard A Kaslow
Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men.
The Journal of infectious diseases 1999;180(2):299-309.
1999: Oscar Pontesilli; SR Kerkhof-Garde; Daan W Notermans; NA Foudraine; Marijke Th L Roos; Michel Klein; Sven A Danner; Joep M A Lange; Frank Miedema
Functional T cell reconstitution and human immunodeficiency virus-1-specific cell-mediated immunity during highly active antiretroviral therapy.
The Journal of infectious diseases 1999;180(1):76-86.
1999: Debbie Van Baarle; Egbert Hovenkamp; Marie José Kersten; Michel Klein; Frank Miedema; Marinus H J van Oers
Direct Epstein-Barr virus (EBV) typing on peripheral blood mononuclear cells: no association between EBV type 2 infection or superinfection and the development of acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma.
Blood 1999;93(11):3949-55.
1999: Oscar Pontesilli; SR Kerkhof-Garde; Nadine Pakker; Daan W Notermans; Marijke Th L Roos; Michel Klein; Sven A Danner; Frank Miedema
Antigen-specific T-lymphocyte proliferative responses during highly active antiretroviral therapy (HAART) of HIV-1 infection.
Immunology letters 1999;66(1-3):213-7.
1999: NA Foudraine; Egbert Hovenkamp; Daan W Notermans; Pieter L Meenhorst; Michel Klein; Joep M A Lange; Frank Miedema; Peter Reiss
Immunopathology as a result of highly active antiretroviral therapy in HIV-1-infected patients.
AIDS (London, England) 1999;13(2):177-84.
1999: Michel Klein; Keith P W J McAdam
CD8+ T lymphocytes against mycobacterium tuberculosis.
Archivum immunologiae et therapiae experimentalis 1999;47(5):313-20.
1999: C Berger; Debbie Van Baarle; Marie José Kersten; Michel Klein; AS al-Homsi; B Dunn; Catherine McQuain; RH van Oers; H Knecht
Carboxy terminal variants of Epstein-Barr virus-encoded latent membrane protein 1 during long-term human immunodeficiency virus infection: reliable markers for individual strain identification.
The Journal of infectious diseases 1999;179(1):240-4.
1998: Oscar Pontesilli; Michel Klein; SR Kerkhof-Garde; Nadine Pakker; Frank de Wolf; Hanneke Schuitemaker; Frank Miedema
Longitudinal analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte responses: a predominant gag-specific response is associated with nonprogressive infection.
The Journal of infectious diseases 1998;178(4):1008-18.
1998: Michel Klein; Sjoerd H van der burg; Egbert Hovenkamp; AM Holwerda; Jan Wouter Drijfhout; Cornelis J M Melief; Frank Miedema
Characterization of HLA-B57-restricted human immunodeficiency virus type 1 Gag- and RT-specific cytotoxic T lymphocyte responses.
The Journal of general virology 1998;79 ( Pt 9)():2191-201.
1998: Michel Klein; Sjoerd H van der burg; Oscar Pontesilli; Frank Miedema
Cytotoxic T lymphocytes in HIV-1 infection: a killing paradox?
Immunology today 1998;19(7):317-24.
1998: AS al-Homsi; C Berger; Debbie Van Baarle; Marie José Kersten; Michel Klein; Catherine McQuain; RH van Oers; H Knecht
Molecular analysis of critical sequences within the EBNA-2 type 1 gene from Epstein-Barr virus isolates from patients with infectious mononucleosis, tonsillar hyperplasia, and HIV infection.
International journal of molecular medicine 1998;1(6):983-7.
1997: Dörte Hamann; Paul A Baars; Martijn Rep; Berend Hooibrink; SR Kerkhof-Garde; Michel Klein; René A W van Lier
Phenotypic and functional separation of memory and effector human CD8+ T cells.
The Journal of experimental medicine 1997;186(9):1407-18.
1997: Sjoerd H van der burg; Michel Klein; Oscar Pontesilli; AM Holwerda; Jan Wouter Drijfhout; W M Kast; Frank Miedema; Cornelis J M Melief
HIV-1 reverse transcriptase-specific CTL against conserved epitopes do not protect against progression to AIDS.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3648-54.
1997: IP Keet; M Janssen; PJ Veugelers; Frank Miedema; Michel Klein; Jaap Goudsmit; Roel A Coutinho; Frank de Wolf
Longitudinal analysis of CD4 T cell counts, T cell reactivity, and human immunodeficiency virus type 1 RNA levels in persons remaining AIDS-free despite CD4 cell counts <200 for >5 years.
The Journal of infectious diseases 1997;176(3):665-71.
1997: Carel A van Baalen; Oscar Pontesilli; RC Huisman; AM Geretti; Michel Klein; Frank de Wolf; Frank Miedema; Rob A Gruters; Albert D M E Osterhaus
Human immunodeficiency virus type 1 Rev- and Tat-specific cytotoxic T lymphocyte frequencies inversely correlate with rapid progression to AIDS.
The Journal of general virology 1997;78 ( Pt 8)():1913-8.
1997: Oscar Pontesilli; Michel Klein; SR Kerkhof-Garde; Nadine Pakker; Frank de Wolf; Hanneke Schuitemaker; Frank Miedema
Kinetics of immune functions and virus replication during HIV-1 infection.
Immunology letters 1997;57(1-3):125-30.
1997: Marie José Kersten; Michel Klein; AM Holwerda; Frank Miedema; Marinus H J van Oers
Epstein-Barr virus-specific cytotoxic T cell responses in HIV-1 infection: different kinetics in patients progressing to opportunistic infection or non-Hodgkin's lymphoma.
The Journal of clinical investigation 1997;99(7):1525-33.
1997: Michel Klein; J Veenstra; AM Holwerda; Marijke Th L Roos; I Gow; G Patou; Roel A Coutinho; Frank de Wolf; Frank Miedema
Gag-specific immune responses after immunization with p17/p24:Ty virus-like particles in HIV type 1-seropositive individuals.
AIDS research and human retroviruses 1997;13(5):393-9.
1997: BM Brinkman; IP Keet; Frank Miedema; Cornelis L Verweij; Michel Klein
Polymorphisms within the human tumor necrosis factor-alpha promoter region in human immunodeficiency virus type 1-seropositive persons.
The Journal of infectious diseases 1997;175(1):188-90.
1996: Carel A van Baalen; Michel Klein; RC Huisman; ME Dings; SR Kerkhof-Garde; AM Geretti; Rob A Gruters; Cecile Van Els; Frank Miedema; A D Osterhaus
Fine-specificity of cytotoxic T lymphocytes which recognize conserved epitopes of the Gag protein of human immunodeficiency virus type 1.
The Journal of general virology 1996;77 ( Pt 8)():1659-65.
1996: Frank Miedema; Michel Klein
AIDS pathogenesis: a finite immune response to blame?
Science (New York, N.Y.) 1996;272(5261):505-6.
1996: IP Keet; Michel Klein; J J Just; Richard A Kaslow
The role of host genetics in the natural history of HIV-1 infection: the needles in the haystack.
AIDS (London, England) 1996;10 Suppl A():S59-67.
1995: Michel Klein; F Miedema
Long-term survivors of HIV-1 infection.
Trends in microbiology 1995;3(10):386-91.
1995: Michel Klein; Carel A van Baalen; AM Holwerda; SR Kerkhof-Garde; Richard Bende; IP Keet; J K Eeftinck-Schattenkerk; A D Osterhaus; Hanneke Schuitemaker; Frank Miedema
Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.
The Journal of experimental medicine 1995;181(4):1365-72.
1995: Sjoerd H van der burg; Michel Klein; Cornelis J H van de Velde; W Martin Kast; Frank Miedema; Cornelis J M Melief
Induction of a primary human cytotoxic T-lymphocyte response against a novel conserved epitope in a functional sequence of HIV-1 reverse transcriptase.
AIDS (London, England) 1995;9(2):121-7.
1994: Frank Miedema; L Meyaard; M Koot; Michel Klein; Marijke Th L Roos; Maarten Groenink; R A Fouchier; Angelica B Van't Wout; M Tersmette; P T Schellekens
Changing virus-host interactions in the course of HIV-1 infection.
Immunological reviews 1994;140():35-72.
1994: Michel Klein; IP Keet; Joseph D'Amaro; Richard Bende; A Hekman; B Mesman; M Koot; L P de Waal; Roel A Coutinho; Frank Miedema
Associations between HLA frequencies and pathogenic features of human immunodeficiency virus type 1 infection in seroconverters from the Amsterdam cohort of homosexual men.
The Journal of infectious diseases 1994;169(6):1244-9.
1994: IP Keet; Anneke Krol; Michel Klein; PJ Veugelers; J de Wit; M Roos; M Koot; Jaap Goudsmit; Frank Miedema; Roel A Coutinho
Characteristics of long-term asymptomatic infection with human immunodeficiency virus type 1 in men with normal and low CD4+ cell counts.
The Journal of infectious diseases 1994;169(6):1236-43.
1993: F Miedema; L Meyaard; Michel Klein
Protection from HIV infection or AIDS?
Science (New York, N.Y.) 1993;262(5136):1074-6.
1993: G J Jochems; Richard Bende; Michel Klein; W P Zeijlemaker; René A W van Lier
Expression of the IL-6 gene induces differentiation of a human monoclonal EBV-transformed B cell line.
Human antibodies and hybridomas 1993;4(3):124-33.
1993: Carel A van Baalen; Michel Klein; AM Geretti; R I Keet; Frank Miedema; Cecile Van Els; A D Osterhaus
Selective in vitro expansion of HLA class I-restricted HIV-1 Gag-specific CD8+ T cells: cytotoxic T-lymphocyte epitopes and precursor frequencies.
AIDS (London, England) 1993;7(6):781-6.
1992: G J Jochems; Michel Klein; W P Zeijlemaker; René A W van Lier
Protein kinase C regulates secretion of lymphotoxin (LT/TNF beta) and TNF alpha by human EBV-transformed B cells.
Human antibodies and hybridomas 1992;3(4):162-7.
1992: Richard Bende; G J Jochems; T H Frame; Michel Klein; R V van Eijk; René A W van Lier; W P Zeijlemaker
Effects of IL-4, IL-5, and IL-6 on growth and immunoglobulin production of Epstein-Barr virus-infected human B cells.
Cellular immunology 1992;143(2):310-23.
1991: G J Jochems; Michel Klein; R Jordens; D Pascual-Salcedo; F van Boxtel-Oosterhof; René A W van Lier; W P Zeijlemaker
Heterogeneity in both cytokine production and responsiveness of a panel of monoclonal human Epstein-Barr virus-transformed B-cell lines.
Human antibodies and hybridomas 1991;2(2):57-64.