David J. Lambeth

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Lee Moo Yeol; San Martin Alejandra; Mehta Puja K; Dikalova Anna E; Garrido Abel Martin; Datla S Raju; Lyons Erin; Krause Karl-Heinz; Banfi Botond; Lambeth J David; Lassègue Bernard; Griendling Kathy K
Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation.
Cheng Guangjie; Salerno John C; Cao Zehong; Pagano Patrick J; Lambeth J David
Identification and characterization of VPO1, a new animal heme-containing peroxidase.
Sharma Pankaj; Chakraborty Rikhia; Wang Lu; Min Booki; Tremblay Michel L; Kawahara Tsukasa; Lambeth J David; Haque S Jaharul
Redox regulation of interleukin-4 signaling.

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2009: Lee Moo Yeol; San Martin Alejandra; Mehta Puja K; Dikalova Anna E; Garrido Abel Martin; Datla S Raju; Lyons Erin; Krause Karl-Heinz; Banfi Botond; Lambeth J David; Lassègue Bernard; Griendling Kathy K
Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(4):480-7.
2008: Cheng Guangjie; Salerno John C; Cao Zehong; Pagano Patrick J; Lambeth J David
Identification and characterization of VPO1, a new animal heme-containing peroxidase.
Free radical biology & medicine 2008;45(12):1682-94.
2008: Sharma Pankaj; Chakraborty Rikhia; Wang Lu; Min Booki; Tremblay Michel L; Kawahara Tsukasa; Lambeth J David; Haque S Jaharul
Redox regulation of interleukin-4 signaling.
Immunity 2008;29(4):551-64.
2008: Kawahara Tsukasa; Lambeth J David
Phosphatidylinositol (4,5)-bisphosphate modulates Nox5 localization via an N-terminal polybasic region.
Molecular biology of the cell 2008;19(10):4020-31.
2008: Lambeth J David; Krause Karl-Heinz; Clark Robert A
NOX enzymes as novel targets for drug development.
Seminars in immunopathology 2008;30(3):339-63.
2008: Laurent Eunice; McCoy James W; Macina Roberto A; Liu Wenhui; Cheng Guangjie; Robine Sylvie; Papkoff Jackie; Lambeth J David
Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras.
International journal of cancer. Journal international du cancer 2008;123(1):100-7.
2008: Chiera Federica; Meccia Ettore; Degan Paolo; Aquilina Gabriele; Pietraforte Donatella; Minetti Maurizio; Lambeth David; Bignami Margherita
Overexpression of human NOX1 complex induces genome instability in mammalian cells.
Free radical biology & medicine 2008;44(3):332-42.
2008: Si Jin; Behar Jose; Wands Jack; Beer David G; Lambeth David; Chin Y Eugene; Cao Weibiao
STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(1):G174-83.
2007: Arnold Rebecca S; He Ju; Remo Andrea; Ritsick Darren; Yin-Goen Qiqin; Lambeth J David; Datta Milton W; Young Andrew N; Petros John A
Nox1 expression determines cellular reactive oxygen and modulates c-fos-induced growth factor, interleukin-8, and Cav-1.
The American journal of pathology 2007;171(6):2021-32.
2007: Lambeth J David
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy.
Free radical biology & medicine 2007;43(3):332-47.
2007: Lambeth J David; Kawahara Tsukasa; Diebold Becky
Regulation of Nox and Duox enzymatic activity and expression.
Free radical biology & medicine 2007;43(3):319-31.
2007: Ritsick Darren R; Edens William A; Finnerty Victoria; Lambeth J David
Nox regulation of smooth muscle contraction.
Free radical biology & medicine 2007;43(1):31-8.
2007: Si Jin; Fu Xiaoying; Behar Jose; Wands Jack; Beer David G; Souza Rhonda F; Spechler Stuart J; Lambeth David; Cao Weibiao
NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells.
The Journal of biological chemistry 2007;282(22):16244-55.
2007: Govindarajan Baskaran; Sligh James E; Vincent Bethaney J; Li Meiling; Canter Jeffrey A; Nickoloff Brian J; Rodenburg Richard J; Smeitink Jan A; Oberley Larry; Zhang Yuping; Slingerland Joyce; Arnold Rebecca S; Lambeth J David; Cohen Cynthia; Hilenski Lu; Griendling Kathy; Martínez-Diez Marta; Cuezva José M; Arbiser Jack L
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.
The Journal of clinical investigation 2007;117(3):719-29.
2007: Kawahara Tsukasa; Lambeth J David
Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes.
BMC evolutionary biology 2007;7():178.
2007: Kawahara Tsukasa; Quinn Mark T; Lambeth J David
Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes.
BMC evolutionary biology 2007;7():109.
2006: Ranjan Priya; Anathy Vikas; Burch Peter M; Weirather Kelly; Lambeth J David; Heintz Nicholas H
Redox-dependent expression of cyclin D1 and cell proliferation by Nox1 in mouse lung epithelial cells.
Antioxidants & redox signaling 2006;8(9-10):1447-59.
2006: Fu Xiaoying; Beer David G; Behar Jose; Wands Jack; Lambeth David; Cao Weibiao
cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells.
The Journal of biological chemistry 2006;281(29):20368-82.
2006: Cheng Guangjie; Diebold Becky A; Hughes Yasmin; Lambeth J David
Nox1-dependent reactive oxygen generation is regulated by Rac1.
The Journal of biological chemistry 2006;281(26):17718-26.
2006: Kondo Shuji; Shimizu Maki; Urushihara Maki; Tsuchiya Koichiro; Yoshizumi Masanori; Tamaki Toshiaki; Nishiyama Akira; Kawachi Hiroshi; Shimizu Fujio; Quinn Mark T; Lambeth David J; Kagami Shoji
Addition of the antioxidant probucol to angiotensin II type I receptor antagonist arrests progressive mesangioproliferative glomerulonephritis in the rat.
Journal of the American Society of Nephrology : JASN 2006;17(3):783-94.
2005: Dikalova Anna; Clempus Roza; Lassègue Bernard; Cheng Guangjie; McCoy James; Dikalov Sergey; San Martin Alejandra; Lyle Alicia; Weber David S; Weiss Daiana; Taylor W Robert; Schmidt Harald H H W; Owens Gary K; Lambeth J David; Griendling Kathy K
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice.
Circulation 2005;112(17):2668-76.
2005: Baniulis Danas; Nakano Yoko; Nauseef William M; Banfi Botond; Cheng Guangjie; Lambeth David J; Burritt James B; Taylor Ross M; Jesaitis Algirdas J
Evaluation of two anti-gp91phox antibodies as immunoprobes for Nox family proteins: mAb 54.1 recognizes recombinant full-length Nox2, Nox3 and the C-terminal domains of Nox1-4 and cross-reacts with GRP 58.
Biochimica et biophysica acta 2005;1752(2):186-96.
2005: Kawahara Tsukasa; Ritsick Darren; Cheng Guangjie; Lambeth J David
Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.
The Journal of biological chemistry 2005;280(36):31859-69.
2005: Ritsick Darren R; Lambeth J David
Spring brings breezes, wheezes, and pollen oxidases.
The Journal of clinical investigation 2005;115(8):2067-9.
2005: Cheng Guangjie; Lambeth J David
Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3.
Gene 2005;356():118-26.
2005: Lim So Dug; Sun Carrie; Lambeth J David; Marshall Fray; Amin Mahul; Chung Leland; Petros John A; Arnold Rebecca S
Increased Nox1 and hydrogen peroxide in prostate cancer.
The Prostate 2005;62(2):200-7.
2004: Cheng Guangjie; Ritsick Darren; Lambeth J David
Nox3 regulation by NOXO1, p47phox, and p67phox.
The Journal of biological chemistry 2004;279(33):34250-5.
2004: Mitsushita Junji; Lambeth J David; Kamata Tohru
The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation.
Cancer research 2004;64(10):3580-5.
2004: Hilenski Lula L; Clempus Roza E; Quinn Mark T; Lambeth J David; Griendling Kathy K
Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(4):677-83.
2004: Lambeth J David
NOX enzymes and the biology of reactive oxygen.
Nature reviews. Immunology 2004;4(3):181-9.
2004: Mahadev Kalyankar; Motoshima Hiroyuki; Wu Xiangdong; Ruddy Jean Marie; Arnold Rebecca S; Cheng Guangjie; Lambeth J David; Goldstein Barry J
The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction.
Molecular and cellular biology 2004;24(5):1844-54.
2004: Cheng Guangjie; Lambeth J David
NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain.
The Journal of biological chemistry 2004;279(6):4737-42.
2004: Ritsick Darren R; Edens William A; McCoy James W; Lambeth J David
The use of model systems to study biological functions of Nox/Duox enzymes.
Biochemical Society symposium 2004;(71):85-96.
2003: Byrne Jonathan A; Grieve David J; Bendall Jennifer K; Li Jian-Mei; Gove Christopher; Lambeth J David; Cave Alison C; Shah Ajay M
Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy.
Circulation research 2003;93(9):802-5.
2003: Brar Sukhdev S; Corbin Zachary; Kennedy Thomas P; Hemendinger Richelle; Thornton Lisa; Bommarius Bettina; Arnold Rebecca S; Whorton A Richard; Sturrock Anne B; Huecksteadt Thomas P; Quinn Mark T; Krenitsky Kevin; Ardie Kristia G; Lambeth J David; Hoidal John R
NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells.
American journal of physiology. Cell physiology 2003;285(2):C353-69.
2002: Yang Dong-Hua; Smith Elizabeth R; Roland Isabelle H; Sheng Zejuan; He Junqi; Martin W David; Hamilton Thomas C; Lambeth J David; Xu Xiang-Xi
Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.
Developmental biology 2002;251(1):27-44.
2002: Price Marianne O; McPhail Linda C; Lambeth J David; Han Chang-Hoon; Knaus Ulla G; Dinauer Mary C
Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system.
Blood 2002;99(8):2653-61.
2002: Sorescu Dan; Weiss Daiana; Lassègue Bernard; Clempus Roza E; Szöcs Katalin; Sorescu George P; Valppu Liisa; Quinn Mark T; Lambeth J David; Vega J David; Taylor W Robert; Griendling Kathy K
Superoxide production and expression of nox family proteins in human atherosclerosis.
Circulation 2002;105(12):1429-35.
2002: Arbiser Jack L; Petros John; Klafter Robert; Govindajaran Baskaran; McLaughlin Elizabeth R; Brown Lawrence F; Cohen Cynthia; Moses Marsha; Kilroy Susan; Arnold Rebecca S; Lambeth J David
Reactive oxygen generated by Nox1 triggers the angiogenic switch.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):715-20.
2002: Babior B M; Lambeth J D; Nauseef W
The neutrophil NADPH oxidase.
Archives of biochemistry and biophysics 2002;397(2):342-4.
2002: Szöcs Katalin; Lassègue Bernard; Sorescu Dan; Hilenski Lula L; Valppu Liisa; Couse Tracey L; Wilcox Josiah N; Quinn Mark T; Lambeth J David; Griendling Kathy K
Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(1):21-7.
2002: Lambeth J David
Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases.
Current opinion in hematology 2002;9(1):11-7.
2001: Edens W A; Sharling L; Cheng G; Shapira R; Kinkade J M; Lee T; Edens H A; Tang X; Sullards C; Flaherty D B; Benian G M; Lambeth J D
Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.
The Journal of cell biology 2001;154(4):879-91.
2001: Cheng G; Cao Z; Xu X; van Meir E G; Lambeth J D
Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.
Gene 2001;269(1-2):131-40.
2001: Lassègue B; Sorescu D; Szöcs K; Yin Q; Akers M; Zhang Y; Grant S L; Lambeth J D; Griendling K K
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways.
Circulation research 2001;88(9):888-94.
2001: Arnold R S; Shi J; Murad E; Whalen A M; Sun C Q; Polavarapu R; Parthasarathy S; Petros J A; Lambeth J D
Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5550-5.
2001: Han C H; Nisimoto Y; Lee S H; Kim E T; Lambeth J D
Characterization of the flavoprotein domain of gp91phox which has NADPH diaphorase activity.
Journal of biochemistry 2001;129(4):513-20.
2000: Jin Z G; Melaragno M G; Liao D F; Yan C; Haendeler J; Suh Y A; Lambeth J D; Berk B C
Cyclophilin A is a secreted growth factor induced by oxidative stress.
Circulation research 2000;87(9):789-96.
2000: Lambeth J D; Cheng G; Arnold R S; Edens W A
Novel homologs of gp91phox.
Trends in biochemical sciences 2000;25(10):459-61.
2000: Tamura M; Kai T; Tsunawaki S; Lambeth J D; Kameda K
Direct interaction of actin with p47(phox) of neutrophil NADPH oxidase.
Biochemical and biophysical research communications 2000;276(3):1186-90.
1999: Suh Y A; Arnold R S; Lassegue B; Shi J; Xu X; Sorescu D; Chung A B; Griendling K K; Lambeth J D
Cell transformation by the superoxide-generating oxidase Mox1.
Nature 1999;401(6748):79-82.
1999: Nisimoto Y; Motalebi S; Han C H; Lambeth J D
The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558).
The Journal of biological chemistry 1999;274(33):22999-3005.
1999: Kim J H; Kim Y; Lee S D; Lopez I; Arnold R S; Lambeth J D; Suh P G; Ryu S H
Selective activation of phospholipase D2 by unsaturated fatty acid.
FEBS letters 1999;454(1-2):42-6.
1998: Kim J H; Lee S D; Han J M; Lee T G; Kim Y; Park J B; Lambeth J D; Suh P G; Ryu S H
Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA.
FEBS letters 1998;430(3):231-5.
1998: Han C H; Freeman J L; Lee T; Motalebi S A; Lambeth J D
Regulation of the neutrophil respiratory burst oxidase. Identification of an activation domain in p67(phox).
The Journal of biological chemistry 1998;273(27):16663-8.
1998: Lopez I; Arnold R S; Lambeth J D
Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2.
The Journal of biological chemistry 1998;273(21):12846-52.
1998: Xu X X; Yi T; Tang B; Lambeth J D
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2.
Oncogene 1998;16(12):1561-9.
1997: Baek S H; Kwak J Y; Lee S H; Lee T; Ryu S H; Uhlinger D J; Lambeth J D
Lipase activities of p37, the major envelope protein of vaccinia virus.
The Journal of biological chemistry 1997;272(51):32042-9.
1997: Nisimoto Y; Freeman J L; Motalebi S A; Hirshberg M; Lambeth J D
Rac binding to p67(phox). Structural basis for interactions of the Rac1 effector region and insert region with components of the respiratory burst oxidase.
The Journal of biological chemistry 1997;272(30):18834-41.
1997: Seo J K; Choi S Y; Kim Y; Baek S H; Kim K T; Chae C B; Lambeth J D; Suh P G; Ryu S H
A peptide with unique receptor specificity: stimulation of phosphoinositide hydrolysis and induction of superoxide generation in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1895-901.
1996: Kreck M L; Freeman J L; Abo A; Lambeth J D
Membrane association of Rac is required for high activity of the respiratory burst oxidase.
Biochemistry 1996;35(49):15683-92.
1996: Kim J H; Suh Y J; Lee T G; Kim Y; Bae S S; Kim M J; Lambeth J D; Suh P G; Ryu S H
Inhibition of phospholipase D by a protein factor from bovine brain cytosol. Partial purification and characterization of the inhibition mechanism.
The Journal of biological chemistry 1996;271(41):25213-9.
1996: Freeman J L; Lambeth J D
NADPH oxidase activity is independent of p47phox in vitro.
The Journal of biological chemistry 1996;271(37):22578-82.
1996: Freeman J L; Abo A; Lambeth J D
Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65.
The Journal of biological chemistry 1996;271(33):19794-801.
1996: Olson S C; Lambeth J D
Biochemistry and cell biology of phospholipase D in human neutrophils.
Chemistry and physics of lipids 1996;80(1-2):3-19.
1995: Kwak J Y; Lopez I; Uhlinger D J; Ryu S H; Lambeth J D
RhoA and a cytosolic 50-kDa factor reconstitute GTP gamma S-dependent phospholipase D activity in human neutrophil subcellular fractions.
The Journal of biological chemistry 1995;270(45):27093-8.
1995: Lopez I; Burns D J; Lambeth J D
Regulation of phospholipase D by protein kinase C in human neutrophils. Conventional isoforms of protein kinase C phosphorylate a phospholipase D-related component in the plasma membrane.
The Journal of biological chemistry 1995;270(33):19465-72.
1995: Nisimoto Y; Otsuka-Murakami H; Lambeth D J
Reconstitution of flavin-depleted neutrophil flavocytochrome b558 with 8-mercapto-FAD and characterization of the flavin-reconstituted enzyme.
The Journal of biological chemistry 1995;270(27):16428-34.
1995: Lambeth J D; Kwak J Y; Bowman E P; Perry D; Uhlinger D J; Lopez I
ADP-ribosylation factor functions synergistically with a 50-kDa cytosolic factor in cell-free activation of human neutrophil phospholipase D.
The Journal of biological chemistry 1995;270(6):2431-4.
1995: Uhlinger D J; Tyagi S R; Lambeth J D
On the mechanism of inhibition of the neutrophil respiratory burst oxidase by a peptide from the C-terminus of the large subunit of cytochrome b558.
Biochemistry 1995;34(2):524-7.
1995: Bowman E P; Uhlinger D J; Lambeth J D
Neutrophil phospholipase D: inhibition by Rho-GDP dissociation inhibitor and stimulation by small GTPase GDP dissociation stimulator.
Methods in enzymology 1995;256():246-56.
1994: Freeman J L; Kreck M L; Uhlinger D J; Lambeth J D
Ras effector-homologue region on Rac regulates protein associations in the neutrophil respiratory burst oxidase complex.
Biochemistry 1994;33(45):13431-5.
1994: Uhlinger D J; Taylor K L; Lambeth J D
p67-phox enhances the binding of p47-phox to the human neutrophil respiratory burst oxidase complex.
The Journal of biological chemistry 1994;269(35):22095-8.
1994: Kreck M L; Uhlinger D J; Tyagi S R; Inge K L; Lambeth J D
Participation of the small molecular weight GTP-binding protein Rac1 in cell-free activation and assembly of the respiratory burst oxidase. Inhibition by a carboxyl-terminal Rac peptide.
The Journal of biological chemistry 1994;269(6):4161-8.
1993: Perry D K; Stevens V L; Widlanski T S; Lambeth J D
A novel ecto-phosphatidic acid phosphohydrolase activity mediates activation of neutrophil superoxide generation by exogenous phosphatidic acid.
The Journal of biological chemistry 1993;268(34):25302-10.
1993: Bowman E P; Uhlinger D J; Lambeth J D
Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.
The Journal of biological chemistry 1993;268(29):21509-12.
1993: Stevens V L; Xu T; Lambeth J D
Cholesterol trafficking in steroidogenic cells. Reversible cycloheximide-dependent accumulation of cholesterol in a pre-steroidogenic pool.
European journal of biochemistry / FEBS 1993;216(2):557-63.
1993: Uhlinger D J; Tyagi S R; Inge K L; Lambeth J D
The respiratory burst oxidase of human neutrophils. Guanine nucleotides and arachidonate regulate the assembly of a multicomponent complex in a semirecombinant cell-free system.
The Journal of biological chemistry 1993;268(12):8624-31.
1992: Perry D K; Hand W L; Edmondson D E; Lambeth J D
Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2749-58.
1992: Uhlinger D J; Inge K L; Kreck M L; Tyagi S R; Neckelmann N; Lambeth J D
Reconstitution and characterization of the human neutrophil respiratory burst oxidase using recombinant p47-phox, p67-phox and plasma membrane.
Biochemical and biophysical research communications 1992;186(1):509-16.
1992: Tyagi S R; Uhlinger D J; Lambeth J D; Champagne C; Van Dyke T E
Altered diacylglycerol level and metabolism in neutrophils from patients with localized juvenile periodontitis.
Infection and immunity 1992;60(6):2481-7.
1992: Tamura M; Takeshita M; Curnutte J T; Uhlinger D J; Lambeth J D
Stabilization of human neutrophil NADPH oxidase activated in a cell-free system by cytosolic proteins and by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide.
The Journal of biological chemistry 1992;267(11):7529-38.
1992: Stevens V L; Xu T; Lambeth J D
Cholesterol pools in rat adrenal mitochondria: use of cholesterol oxidase to infer a complex pool structure.
Endocrinology 1992;130(3):1557-63.
1992: Tyagi S R; Neckelmann N; Uhlinger D J; Burnham D N; Lambeth J D
Cell-free translocation of recombinant p47-phox, a component of the neutrophil NADPH oxidase: effects of guanosine 5'-O-(3-thiotriphosphate), diacylglycerol, and an anionic amphiphile.
Biochemistry 1992;31(10):2765-74.
1991: Uhlinger D J; Burnham D N; Lambeth J D
Nucleoside triphosphate requirements for superoxide generation and phosphorylation in a cell-free system from human neutrophils. Sodium dodecyl sulfate and diacylglycerol activate independently of protein kinase C.
The Journal of biological chemistry 1991;266(31):20990-7.
1991: Olson S C; Bowman E P; Lambeth J D
Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.
The Journal of biological chemistry 1991;266(26):17236-42.
1991: Uhlinger D J; Burnham D N; Mullins R E; Kalmar J R; Cutler C W; Arnold R R; Lambeth J D; Merrill A H
Functional differences in human neutrophils isolated pre- and post-prandially.
FEBS letters 1991;286(1-2):28-32.
1991: Xu T S; Bowman E P; Glass D B; Lambeth J D
Stimulation of adrenal mitochondrial cholesterol side-chain cleavage by GTP, steroidogenesis activator polypeptide (SAP), and sterol carrier protein2. GTP and SAP act synergistically.
The Journal of biological chemistry 1991;266(11):6801-7.
1991: Tyagi S R; Olson S C; Burnham D N; Lambeth J D
Cyclic AMP-elevating agents block chemoattractant activation of diradylglycerol generation by inhibiting phospholipase D activation.
The Journal of biological chemistry 1991;266(6):3498-504.
1991: Glass D B; Robertson D G; Xu T S; Bowman E P; Lambeth J D
Chemical synthesis, initial conformational studies, and activity of rat steroidogenesis activator peptide and a truncated analog.
Endocrine research 1991;17(1-2):307-26.
1991: Robertson D G; Perry D; Lambeth J D
Inhibition of mitochondrial cholesterol side-chain cleavage by structural analogs of cholesterol sulfate.
Endocrine research 1991;17(1-2):297-306.
1990: Olson S C; Tyagi S R; Lambeth J D
Fluoride activates diradylglycerol and superoxide generation in human neutrophils via PLD/PA phosphohydrolase-dependent and -independent pathways.
FEBS letters 1990;272(1-2):19-24.
1990: Burnham D N; Uhlinger D J; Lambeth J D
Diradylglycerol synergizes with an anionic amphiphile to activate superoxide generation and phosphorylation of p47phox in a cell-free system from human neutrophils.
The Journal of biological chemistry 1990;265(29):17550-9.
1989: Tamura M; Tamura T; Burnham D N; Uhlinger D J; Lambeth J D
Stabilization of the superoxide-generating respiratory burst oxidase of human neutrophil plasma membrane by crosslinking with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide.
Archives of biochemistry and biophysics 1989;275(1):23-32.
1989: Xu X S; Xu T S; Robertson D G; Lambeth J D
GTP stimulates pregnenolone generation in isolated rat adrenal mitochondria.
The Journal of biological chemistry 1989;264(30):17674-80.
1989: Tyagi S R; Winton E F; Lambeth J D
Granulocyte/macrophage colony-stimulating factor primes human neutrophils for increased diacylglycerol generation in response to chemoattractant.
FEBS letters 1989;257(1):188-90.
1989: Tyagi S R; Burnham D N; Lambeth J D
On the biological occurrence and regulation of 1-acyl and 1-O-alkyl-diradylglycerols in human neutrophils. Selective destruction of diacyl species using Rhizopus lipase.
The Journal of biological chemistry 1989;264(22):12977-82.
1989: Xu X X; Lambeth J D
Cholesterol sulfate is a naturally occurring inhibitor of steroidogenesis in isolated rat adrenal mitochondria.
The Journal of biological chemistry 1989;264(13):7222-7.
1989: Merrill A H; Nimkar S; Menaldino D; Hannun Y A; Loomis C; Bell R M; Tyagi S R; Lambeth J D; Stevens V L; Hunter R
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds.
Biochemistry 1989;28(8):3138-45.
1989: Robertson D G; DiGirolamo M; Merrill A H; Lambeth J D
Insulin-stimulated hexose transport and glucose oxidation in rat adipocytes is inhibited by sphingosine at a step after insulin binding.
The Journal of biological chemistry 1989;264(12):6773-9.
1989: Burnham D N; Tyagi S R; Uhlinger D J; Lambeth J D
Diacylglycerol generation and phosphoinositide turnover in human neutrophils: effects of particulate versus soluble stimuli.
Archives of biochemistry and biophysics 1989;269(1):345-53.
1989: Lambeth J D; Xu X X
Cholesterol sulfate: a naturally-occurring inhibitor of cholesterol side-chain cleavage which functions at the level of intramitochondrial cholesterol translocation.
Endocrine research 1989;15(1-2):85-99.
1988: Lambeth J D
Introduction: respiratory burst oxidase and its regulation.
Journal of bioenergetics and biomembranes 1988;20(6):633-5.
1988: Lambeth J D
Activation of the respiratory burst oxidase in neutrophils: on the role of membrane-derived second messengers, Ca++, and protein kinase C.
Journal of bioenergetics and biomembranes 1988;20(6):709-33.
1988: Tamura M; Tamura T; Tyagi S R; Lambeth J D
The superoxide-generating respiratory burst oxidase of human neutrophil plasma membrane. Phosphatidylserine as an effector of the activated enzyme.
The Journal of biological chemistry 1988;263(33):17621-6.
1988: Tyagi S R; Tamura M; Burnham D N; Lambeth J D
Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.
The Journal of biological chemistry 1988;263(26):13191-8.
1988: Fowler W T; Lambeth J D; Powell G L
Photoreactive cardiolipin analogues.
Chemistry and physics of lipids 1988;47(4):261-71.
1988: Nisimoto Y; Tamura M; Lambeth J D
A menadione-stimulated pyridine nucleotide oxidase from resting bovine neutrophil membranes. Purification, properties, and immunochemical cross-reactivity with the human neutrophil NADPH oxidase.
The Journal of biological chemistry 1988;263(24):11657-63.
1988: Wilson E; Wang E; Mullins R E; Uhlinger D J; Liotta D C; Lambeth J D; Merrill A H
Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.
The Journal of biological chemistry 1988;263(19):9304-9.
1988: Lambeth J D; Burnham D N; Tyagi S R
Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affecting inhibition of the respiratory burst.
The Journal of biological chemistry 1988;263(8):3818-22.
1987: Wilson E; Rice W G; Kinkade J M; Merrill A H; Arnold R R; Lambeth J D
Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils.
Archives of biochemistry and biophysics 1987;259(1):204-14.
1987: Deli E; Kiss Z; Wilson E; Lambeth J D; Kuo J F
Immunocytochemical localization of protein kinase C in resting and activated human neutrophils.
FEBS letters 1987;221(2):365-9.
1987: Lambeth J D; Xu X X; Glover M
Cholesterol sulfate inhibits adrenal mitochondrial cholesterol side chain cleavage at a site distinct from cytochrome P-450scc. Evidence for an intramitochondrial cholesterol translocator.
The Journal of biological chemistry 1987;262(19):9181-8.
1987: Tuls J; Geren L; Lambeth J D; Millett F
The use of a specific fluorescence probe to study the interaction of adrenodoxin with adrenodoxin reductase and cytochrome P-450scc.
The Journal of biological chemistry 1987;262(21):10020-5.
1987: Wilson E; Laster S M; Gooding L R; Lambeth J D
Platelet-derived growth factor stimulates phagocytosis and blocks agonist-induced activation of the neutrophil oxidative burst: a possible cellular mechanism to protect against oxygen radical damage.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2213-7.
1987: Tribble D L; Glover M R; Lambeth J D
Pregnenolone production by adrenal mitochondria: a new high-performance liquid chromatographic analytical method for cholesterol side-chain cleavage.
Journal of chromatography 1987;414(2):411-6.
1986: Wilson E; Olcott M C; Bell R M; Merrill A H; Lambeth J D
Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.
The Journal of biological chemistry 1986;261(27):12616-23.
1986: Stevens V L; Lambeth J D; Merrill A H
Use of cytochrome P-450scc to measure cholesterol-lipid interactions.
Biochemistry 1986;25(15):4287-92.
1986: Heyl B L; Tyrrell D J; Lambeth J D
Cytochrome P-450scc-substrate interactions. Role of the 3 beta- and side chain hydroxyls in binding to oxidized and reduced forms of the enzyme.
The Journal of biological chemistry 1986;261(6):2743-9.
1986: Nisimoto Y; Wilson E; Heyl B L; Lambeth J D
NADH dehydrogenase from bovine neutrophil membranes. Purification and properties.
The Journal of biological chemistry 1986;261(1):285-90.
1986: Lambeth J D
Cytochrome P-450scc a review of the specificity and properties of the cholesterol binding site.
Endocrine research 1986;12(4):371-92.
1985: Stevens V L; Tribble D L; Lambeth J D
Regulation of mitochondrial compartment volumes in rat adrenal cortex by ether stress.
Archives of biochemistry and biophysics 1985;242(1):324-7.
1985: Nisimoto Y; Lambeth J D
NADPH-cytochrome P-450 reductase-cytochrome b5 interactions: crosslinking of the phospholipid vesicle-associated proteins by a water-soluble carbodiimide.
Archives of biochemistry and biophysics 1985;241(2):386-96.
1985: Lambeth J D; Kriengsiri S
Cytochrome P-450scc-adrenodoxin interactions. Ionic effects on binding, and regulation of cytochrome reduction by bound steroid substrates.
The Journal of biological chemistry 1985;260(15):8810-6.
1985: Kamin H; Batie C; Lambeth J D; Lancaster J; Graham L; Salerno J C
Paramagnetic probes of multicomponent electron-transfer systems.
Biochemical Society transactions 1985;13(3):615-8.
1984: Pember S O; Heyl B L; Kinkade J M; Lambeth J D
Cytochrome b558 from (bovine) granulocytes. Partial purification from Triton X-114 extracts and properties of the isolated cytochrome.
The Journal of biological chemistry 1984;259(16):10590-5.
1984: Lambeth J D; Geren L M; Millett F
Adrenodoxin interaction with adrenodoxin reductase and cytochrome P-450scc. Cross-linking of protein complexes and effects of adrenodoxin modification by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.
The Journal of biological chemistry 1984;259(16):10025-9.
1984: Stevens V L; Aw T Y; Jones D P; Lambeth J D
Oxygen dependence of adrenal cortex cholesterol side chain cleavage. Implications in the rate-limiting steps in steroidogenesis.
The Journal of biological chemistry 1984;259(2):1174-9.
1984: Lambeth J D; Stevens V L
Cytochrome P-450scc: enzymology, and the regulation of intramitochondrial cholesterol delivery to the enzyme.
Endocrine research 1984;10(3-4):283-309.
1983: Vahouny G V; Chanderbhan R; Noland B J; Irwin D; Dennis P; Lambeth J D; Scallen T J
Sterol carrier protein2. Identification of adrenal sterol carrier protein2 and site of action for mitochondrial cholesterol utilization.
The Journal of biological chemistry 1983;258(19):11731-7.
1983: Lambeth J D; Pember S O
Cytochrome P-450scc-adrenodoxin complex. Reduction properties of the substrate-associated cytochrome and relation of the reduction states of heme and iron-sulfur centers to association of the proteins.
The Journal of biological chemistry 1983;258(9):5596-602.
1983: Lambeth J D
22-Ketocholesterol. A potent competitive inhibitor of cytochrome P-450scc-dependent side-chain cleavage of cholesterol.
Molecular pharmacology 1983;23(3):743-7.
1983: Pember S O; Powell G L; Lambeth J D
Cytochrome P-450scc-phospholipid interactions. Evidence for a cardiolipin binding site and thermodynamics of enzyme interactions with cardiolipin, cholesterol, and adrenodoxin.
The Journal of biological chemistry 1983;258(5):3198-206.
1982: Kramer R E; Du Bois R N; Simpson E R; Anderson C M; Kashiwagi K; Lambeth J D; Jefcoate C R; Waterman M R
Cell-free synthesis of precursor forms of mitochondrial steroid hydroxylase enzymes of the bovine adrenal cortex.
Archives of biochemistry and biophysics 1982;215(2):478-85.
1982: Lambeth J D; Seybert D W; Lancaster J R; Salerno J C; Kamin H
Steroidogenic electron transport in adrenal cortex mitochondria.
Molecular and cellular biochemistry 1982;45(1):13-31.
1982: Lambeth J D; Kitchen S E; Farooqui A A; Tuckey R; Kamin H
Cytochrome P-450scc-substrate interactions. Studies of binding and catalytic activity using hydroxycholesterols.
The Journal of biological chemistry 1982;257(4):1876-84.
1981: Lambeth J D
Cytochrome P-450scc. Cardiolipin as an effector of activity of a mitochondrial cytochrome P-450.
The Journal of biological chemistry 1981;256(10):4757-62.
1981: Lambeth J D; Lancaster J R; Kamin H
Steroidogenic electron transport by adrenodoxin reductase and adrenodoxin. Use of acetylated cytochrome c as a mechanistic probe of electron transfer.
The Journal of biological chemistry 1981;256(8):3674-8.
1981: DuBois R N; Simpson E R; Tuckey J; Lambeth J D; Waterman M R
Evidence for a higher molecular weight precursor of cholesterol side-chain-cleavage cytochrome P-450 and induction of mitochondrial and cytosolic proteins by corticotropin in adult bovine adrenal cells.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(2):1028-32.
1981: Merrill A H; Lambeth J D; Edmondson D E; McCormick D B
Formation and mode of action of flavoproteins.
Annual review of nutrition 1981;1():281-317.
1980: Lambeth J D; Kamin H; Seybert D W
Phosphatidylcholine vesicle reconstituted cytochrome P-450scc. Role of the membrane in control of activity and spin state of the cytochrome.
The Journal of biological chemistry 1980;255(17):8282-8.
1980: Lambeth J D; Seybert D W; Kamin H
Adrenodoxin reductase . adrenodoxin complex. Rapid formation and breakdown of the complex and a slow conformational change in the flavoprotein.
The Journal of biological chemistry 1980;255(10):4667-72.
1980: Hall C L; Lambeth J D
Studies on electron transfer from general acyl-CoA dehydrogenase to electron transfer flavoprotein.
The Journal of biological chemistry 1980;255(8):3591-5.
1980: Lambeth J D; Seybert D W; Kamin H
Phospholipid vesicle-reconstituted cytochrome P-450SCC. Mutually facilitated binding of cholesterol and adrenodoxin.
The Journal of biological chemistry 1980;255(1):138-43.
1979: Seybert D W; Lancaster J R; Lambeth J D; Kamin H
Participation of the membrane in the side chain cleavage of cholesterol. Reconstitution of cytochrome P-450scc into phospholipid vesicles.
The Journal of biological chemistry 1979;254(23):12088-98.
1979: Lambeth J D; Seybert D W; Kamin H
Ionic effects on adrenal steroidogenic electron transport. The role of adrenodoxin as an electron shuttle.
The Journal of biological chemistry 1979;254(15):7255-64.
1979: Lambeth J D; Kamin H
Adrenodoxin reductase.adrenodoxin complex. Flavin to iron-sulfur electron transfer as the rate-limiting step in the NADPH-cytochrome c reductase reaction.
The Journal of biological chemistry 1979;254(8):2766-74.
1979: Hall C L; Lambeth J D; Kamin H
Acyl-CoA complexes of general acyl-CoA dehydrogenase and electron transfer flavoprotein.
The Journal of biological chemistry 1979;254(6):2023-31.
1978: Seybert D W; Lambeth J D; Kamin H
The participation of a second molecule of adrenodoxin in cytochrome P-450-catalyzed 11beta hydroxylation.
The Journal of biological chemistry 1978;253(23):8355-8.
1977: Lambeth J D; Kamin H
Adrenodoxin reductase and adrenodoxin. Mechanisms of reduction of ferricyanide and cytochrome c.
The Journal of biological chemistry 1977;252(9):2908-17.
1976: Lambeth J D; McCaslin D R; Kamin H
Adrenodoxin reductase-adrenodexin complex.
The Journal of biological chemistry 1976;251(23):7545-50.
1976: Lambeth J D; Kamin H
Adrenodoxin reductase. Properties of the complexes of reduced enzyme with NADP+ and NADPH.
The Journal of biological chemistry 1976;251(14):4299-306.
1973: Estabrook R W; Mason J I; Baron J; Lambeth D; Waterman M
Drugs, alcohol and sex hormones: a molecular perspective of the receptivity of cytochrome P-450.
Annals of the New York Academy of Sciences 1973;212():27-49.

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