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David J. Lambeth

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Karl-Heinz Krause; David J. Lambeth; Martin Krönke
NOX enzymes as drug targets.
Augusto C Montezano; Dylan Burger; Tamara M Paravicini; Andreia Z Chignalia; Hiba Yusuf; Mahmoud Almasri; Ying He; Glaucia E Callera; Gang He; Karl-Heinz Krause; David J. Lambeth; Mark T Quinn; Rhian M Touyz
Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells.
Yukio Nisimoto; Heather M Jackson; Hisamitsu Ogawa; Tsukasa Kawahara; David J. Lambeth
Constitutive NADPH-dependent electron transferase activity of the Nox4 dehydrogenase domain.

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All Publications

2012: Karl-Heinz Krause; David J. Lambeth; Martin Krönke
NOX enzymes as drug targets.
Cellular and molecular life sciences : CMLS 2012;69(14):2279-82.
2010: Augusto C Montezano; Dylan Burger; Tamara M Paravicini; Andreia Z Chignalia; Hiba Yusuf; Mahmoud Almasri; Ying He; Glaucia E Callera; Gang He; Karl-Heinz Krause; David J. Lambeth; Mark T Quinn; Rhian M Touyz
Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells.
Circulation research 2010;106(8):1363-73.
2010: Yukio Nisimoto; Heather M Jackson; Hisamitsu Ogawa; Tsukasa Kawahara; David J. Lambeth
Constitutive NADPH-dependent electron transferase activity of the Nox4 dehydrogenase domain.
Biochemistry 2010;49(11):2433-42.
2010: Jie Hong; Jose Behar; Jack Wands; Murray Resnick; Li Juan Wang; Ronald A DeLellis; David J. Lambeth; Weibiao Cao
Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cgamma2 and NADPH oxidase NOX5-S.
Cancer research 2010;70(3):1247-55.
2010: Jie Hong; Jose Behar; Jack Wands; Murray Resnick; Li Juan Wang; Ronald A DeLellis; David J. Lambeth; Rhonda F Souza; Stuart J Spechler; Weibiao Cao
Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma.
Gut 2010;59(2):170-80.
2009: Moo Yeol Lee; Alejandra San Martin; Puja K Mehta; Anna Dikalova; Abel Martin Garrido; Srinivasa Datla; Erin Lyons; Karl-Heinz Krause; Botond Banfi; David J. Lambeth; Bernard Lassègue; Kathy K Griendling
Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(4):480-7.
2008: Guangjie Cheng; John Salerno; Zehong Cao; Patrick J Pagano; David J. Lambeth
Identification and characterization of VPO1, a new animal heme-containing peroxidase.
Free radical biology & medicine 2008;45(12):1682-94.
2008: Pankaj Sharma; Rikhia Chakraborty; Lu Wang; Booki Min; Michel L Tremblay; Tsukasa Kawahara; David J. Lambeth; S Jaharul Haque
Redox regulation of interleukin-4 signaling.
Immunity 2008;29(4):551-64.
2008: Tsukasa Kawahara; David J. Lambeth
Phosphatidylinositol (4,5)-bisphosphate modulates Nox5 localization via an N-terminal polybasic region.
Molecular biology of the cell 2008;19(10):4020-31.
2008: David J. Lambeth; Karl-Heinz Krause; Robert Clark
NOX enzymes as novel targets for drug development.
Seminars in immunopathology 2008;30(3):339-63.
2008: Eunice Laurent; James W McCoy; Roberto A Macina; Wenhui Liu; Guangjie Cheng; Sylvie Robine; Jackie Papkoff; David J. Lambeth
Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras.
International journal of cancer. Journal international du cancer 2008;123(1):100-7.
2008: Federica Chiera; ettore meccia; Paolo Degan; Gabriele Aquilina; Donatella Pietraforte; Maurizio Minetti; David J. Lambeth; Margherita Bignami
Overexpression of human NOX1 complex induces genome instability in mammalian cells.
Free radical biology & medicine 2008;44(3):332-42.
2008: Jin Si; Jose Behar; Jack Wands; David G Beer; David J. Lambeth; Y Eugene Chin; Weibiao Cao
STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(1):G174-83.
2007: Rebecca S Arnold; Ju He; Andrea Remo; Darren R Ritsick; Qiqin Yin-Goen; David J. Lambeth; Milton W Datta; Andrew N Young; John Petros
Nox1 expression determines cellular reactive oxygen and modulates c-fos-induced growth factor, interleukin-8, and Cav-1.
The American journal of pathology 2007;171(6):2021-32.
2007: David J. Lambeth
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy.
Free radical biology & medicine 2007;43(3):332-47.
2007: David J. Lambeth; Tsukasa Kawahara; Becky Diebold
Regulation of Nox and Duox enzymatic activity and expression.
Free radical biology & medicine 2007;43(3):319-31.
2007: Darren R Ritsick; William A Edens; Victoria Finnerty; David J. Lambeth
Nox regulation of smooth muscle contraction.
Free radical biology & medicine 2007;43(1):31-8.
2007: Jin Si; Xiaoying Fu; Jose Behar; Jack R Wands; David G Beer; Rhonda F Souza; Stuart Jon Spechler; David J. Lambeth; Weibiao Cao
NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells.
The Journal of biological chemistry 2007;282(22):16244-55.
2007: Baskaran Govindarajan; James E Sligh; Bethaney J Vincent; Meiling Li; Jeffrey A Canter; Brian J Nickoloff; Richard J Rodenburg; Jan A M Smeitink; Larry Oberley; Yuping Zhang; Joyce M Slingerland; Rebecca S Arnold; David J. Lambeth; Cynthia Cohen; Lula Hilenski; Kathy K Griendling; Marta Martínez-Diez; José M Cuezva; Jack L Arbiser
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.
The Journal of clinical investigation 2007;117(3):719-29.
2007: Tsukasa Kawahara; David J. Lambeth
Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes.
BMC evolutionary biology 2007;7():178.
2007: Tsukasa Kawahara; Mark T Quinn; David J. Lambeth
Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes.
BMC evolutionary biology 2007;7():109.
2006: Priya Ranjan; Vikas Anathy; Peter M Burch; Kelly Weirather; David J. Lambeth; Nicholas H Heintz
Redox-dependent expression of cyclin D1 and cell proliferation by Nox1 in mouse lung epithelial cells.
Antioxidants & redox signaling 2006;8(9-10):1447-59.
2006: Xiaoying Fu; David G Beer; Jose Behar; Jack R Wands; David J. Lambeth; Weibiao Cao
cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells.
The Journal of biological chemistry 2006;281(29):20368-82.
2006: Guangjie Cheng; Becky A Diebold; Yasmin Hughes; David J. Lambeth
Nox1-dependent reactive oxygen generation is regulated by Rac1.
The Journal of biological chemistry 2006;281(26):17718-26.
2006: Shuji Kondo; Maki Shimizu; Maki Urushihara; Koichiro Tsuchiya; Masanori Yoshizumi; Toshiaki Tamaki; Akira Nishiyama; Hiroshi Kawachi; Fujio Shimizu; Mark T Quinn; David J. Lambeth; Shoji Kagami
Addition of the antioxidant probucol to angiotensin II type I receptor antagonist arrests progressive mesangioproliferative glomerulonephritis in the rat.
Journal of the American Society of Nephrology : JASN 2006;17(3):783-94.
2005: Anna Dikalova; Roza E Clempus; Bernard Lassègue; Guangjie Cheng; James McCoy; Sergey Dikalov; Alejandra San Martin; Alicia N Lyle; David S Weber; Daiana Weiss; W. Robert Taylor; Harald Schmidt; Gary K Owens; David J. Lambeth; Kathy K Griendling
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice.
Circulation 2005;112(17):2668-76.
2005: Danas Baniulis; Yoko Nakano; William M Nauseef; Botond Banfi; Guangjie Cheng; David J. Lambeth; James B Burritt; Ross M Taylor; Algirdas J Jesaitis
Evaluation of two anti-gp91phox antibodies as immunoprobes for Nox family proteins: mAb 54.1 recognizes recombinant full-length Nox2, Nox3 and the C-terminal domains of Nox1-4 and cross-reacts with GRP 58.
Biochimica et biophysica acta 2005;1752(2):186-96.
2005: Tsukasa Kawahara; Darren R Ritsick; Guangjie Cheng; David J. Lambeth
Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.
The Journal of biological chemistry 2005;280(36):31859-69.
2005: Guangjie Cheng; David J. Lambeth
Alternative mRNA splice forms of NOXO1: differential tissue expression and regulation of Nox1 and Nox3.
Gene 2005;356():118-26.
2005: Darren R Ritsick; David J. Lambeth
Spring brings breezes, wheezes, and pollen oxidases.
The Journal of clinical investigation 2005;115(8):2067-9.
2005: So Dug Lim; Carrie Sun; David J. Lambeth; Fray Marshall; Mahul B Amin; Leland W K Chung; John Petros; Rebecca S Arnold
Increased Nox1 and hydrogen peroxide in prostate cancer.
The Prostate 2005;62(2):200-7.
2004: Guangjie Cheng; Darren R Ritsick; David J. Lambeth
Nox3 regulation by NOXO1, p47phox, and p67phox.
The Journal of biological chemistry 2004;279(33):34250-5.
2004: Junji Mitsushita; David J. Lambeth; Tohru Kamata
The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation.
Cancer research 2004;64(10):3580-5.
2004: Lula Hilenski; Roza E Clempus; Mark T Quinn; David J. Lambeth; Kathy K Griendling
Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(4):677-83.
2004: David J. Lambeth
NOX enzymes and the biology of reactive oxygen.
Nature reviews. Immunology 2004;4(3):181-9.
2004: Kalyankar Mahadev; Hiroyuki Motoshima; Xiangdong Wu; Jean Marie Ruddy; Rebecca S Arnold; Guangjie Cheng; David J. Lambeth; Barry J Goldstein
The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction.
Molecular and cellular biology 2004;24(5):1844-54.
2004: Guangjie Cheng; David J. Lambeth
NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain.
The Journal of biological chemistry 2004;279(6):4737-42.
2004: Darren R Ritsick; William A Edens; James W McCoy; David J. Lambeth
The use of model systems to study biological functions of Nox/Duox enzymes.
Biochemical Society symposium 2004;(71):85-96.
2003: Jonathan A Byrne; David J Grieve; Jennifer K Bendall; Jian-Mei Li; Christopher Gove; David J. Lambeth; Alison C Cave; Ajay M Shah
Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy.
Circulation research 2003;93(9):802-5.
2003: Sukhdev S Brar; Zachary Corbin; Thomas P Kennedy; Richelle Hemendinger; Lisa Thornton; Bettina Bommarius; Rebecca S Arnold; A Richard Whorton; Anne B Sturrock; Thomas P Huecksteadt; Mark T Quinn; Kevin Krenitsky; Kristia G Ardie; David J. Lambeth; John R Hoidal
NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells.
American journal of physiology. Cell physiology 2003;285(2):C353-69.
2002: Dong-Hua Yang; Elizabeth Smith; Isabelle H Roland; Zejuan Sheng; Junqi He; W David Martin; Thomas C Hamilton; David J. Lambeth; Xiangxi Xu
Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.
Developmental biology 2002;251(1):27-44.
2002: Marianne O Price; Linda C McPhail; David J. Lambeth; Chang-Hoon Han; Ulla G Knaus; Mary C Dinauer
Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system.
Blood 2002;99(8):2653-61.
2002: Dan Sorescu; Daiana Weiss; Bernard Lassègue; Roza E Clempus; Katalin Szöcs; George P Sorescu; Liisa Valppu; Mark T Quinn; David J. Lambeth; J David Vega; W. Robert Taylor; Kathy K Griendling
Superoxide production and expression of nox family proteins in human atherosclerosis.
Circulation 2002;105(12):1429-35.
2002: Jack L Arbiser; John Petros; Robert Klafter; Baskaran Govindajaran; Elizabeth R McLaughlin; Lawrence F Brown; Cynthia Cohen; Marsha A Moses; Susan Kilroy; Rebecca S Arnold; David J. Lambeth
Reactive oxygen generated by Nox1 triggers the angiogenic switch.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):715-20.
2002: Bernard M Babior; David J. Lambeth; W Nauseef
The neutrophil NADPH oxidase.
Archives of biochemistry and biophysics 2002;397(2):342-4.
2002: Katalin Szöcs; Bernard Lassègue; Dan Sorescu; Lula Hilenski; Liisa Valppu; Tracey L Couse; Josiah N Wilcox; Mark T Quinn; David J. Lambeth; Kathy K Griendling
Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(1):21-7.
2002: David J. Lambeth
Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases.
Current opinion in hematology 2002;9(1):11-7.
2001: William A Edens; L Sharling; Guangjie Cheng; R Shapira; J M Kinkade; T Lee; Heather A Edens; X Tang; C Sullards; Denise B Flaherty; Guy M Benian; David J. Lambeth
Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.
The Journal of cell biology 2001;154(4):879-91.
2001: Guangjie Cheng; Z Cao; Xiangxi Xu; Erwin Van Meir; David J. Lambeth
Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.
Gene 2001;269(1-2):131-40.
2001: Bernard Lassègue; Dan Sorescu; Katalin Szöcs; Qiqin Yin; Marjorie L Akers; Y Zhang; S L Grant; David J. Lambeth; Kathy K Griendling
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways.
Circulation research 2001;88(9):888-94.
2001: Rebecca S Arnold; J Shi; Emma Murad; A M Whalen; Carrie Q Sun; Rohini Polavarapu; Sampath Parthasarathy; John Petros; David J. Lambeth
Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5550-5.
2001: CH Han; Yukio Nisimoto; S H Lee; E T Kim; David J. Lambeth
Characterization of the flavoprotein domain of gp91phox which has NADPH diaphorase activity.
Journal of biochemistry 2001;129(4):513-20.
2000: Zheng-Gen Jin; Matthew G Melaragno; D F Liao; Chen Yan; Judith Haendeler; Y A Suh; David J. Lambeth; Bradford C Berk
Cyclophilin A is a secreted growth factor induced by oxidative stress.
Circulation research 2000;87(9):789-96.
2000: Minoru Tamura; T Kai; S Tsunawaki; David J. Lambeth; K Kameda
Direct interaction of actin with p47(phox) of neutrophil NADPH oxidase.
Biochemical and biophysical research communications 2000;276(3):1186-90.
2000: David J. Lambeth; Guangjie Cheng; Rebecca S Arnold; William A Edens
Novel homologs of gp91phox.
Trends in biochemical sciences 2000;25(10):459-61.
1999: Y A Suh; Rebecca S Arnold; B Lassegue; J Shi; Xiangxi Xu; Dan Sorescu; AB Chung; Kathy K Griendling; David J. Lambeth
Cell transformation by the superoxide-generating oxidase Mox1.
Nature 1999;401(6748):79-82.
1999: Yukio Nisimoto; SA Motalebi; CH Han; David J. Lambeth
The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558).
The Journal of biological chemistry 1999;274(33):22999-3005.
1999: Jong Hyun Kim; Youndong Kim; Sang Do Lee; I Lopez; Rebecca S Arnold; David J. Lambeth; Pann-Ghill Suh; Sung Ho Ryu
Selective activation of phospholipase D2 by unsaturated fatty acid.
FEBS letters 1999;454(1-2):42-6.
1998: Jong Hyun Kim; Sang Do Lee; Jung Min Han; Taehoon G Lee; Youndong Kim; Jong Bae Park; David J. Lambeth; Pann-Ghill Suh; Sung Ho Ryu
Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA.
FEBS letters 1998;430(3):231-5.
1998: CH Han; J L Freeman; T Lee; SA Motalebi; David J. Lambeth
Regulation of the neutrophil respiratory burst oxidase. Identification of an activation domain in p67(phox).
The Journal of biological chemistry 1998;273(27):16663-8.
1998: I Lopez; Rebecca S Arnold; David J. Lambeth
Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2.
The Journal of biological chemistry 1998;273(21):12846-52.
1998: Xiangxi Xu; T Yi; B Tang; David J. Lambeth
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2.
Oncogene 1998;16(12):1561-9.
1997: S H Baek; J Y Kwak; S H Lee; T Lee; S H Ryu; D J Uhlinger; David J. Lambeth
Lipase activities of p37, the major envelope protein of vaccinia virus.
The Journal of biological chemistry 1997;272(51):32042-9.
1997: Yukio Nisimoto; J L Freeman; SA Motalebi; M Hirshberg; David J. Lambeth
Rac binding to p67(phox). Structural basis for interactions of the Rac1 effector region and insert region with components of the respiratory burst oxidase.
The Journal of biological chemistry 1997;272(30):18834-41.
1997: JK Seo; So Young Choi; Youndong Kim; S H Baek; Kyong-Tai Kim; Chi-Bom Chae; David J. Lambeth; Pann-Ghill Suh; Sung Ho Ryu
A peptide with unique receptor specificity: stimulation of phosphoinositide hydrolysis and induction of superoxide generation in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1895-901.
1996: M L Kreck; J L Freeman; A Abo; David J. Lambeth
Membrane association of Rac is required for high activity of the respiratory burst oxidase.
Biochemistry 1996;35(49):15683-92.
1996: J H Kim; Y J Suh; Taehoon G Lee; Youndong Kim; S S Bae; Min-Jung Kim; David J. Lambeth; Pann-Ghill Suh; Sung Ho Ryu
Inhibition of phospholipase D by a protein factor from bovine brain cytosol. Partial purification and characterization of the inhibition mechanism.
The Journal of biological chemistry 1996;271(41):25213-9.
1996: J L Freeman; David J. Lambeth
NADPH oxidase activity is independent of p47phox in vitro.
The Journal of biological chemistry 1996;271(37):22578-82.
1996: J L Freeman; A Abo; David J. Lambeth
Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65.
The Journal of biological chemistry 1996;271(33):19794-801.
1996: S C Olson; David J. Lambeth
Biochemistry and cell biology of phospholipase D in human neutrophils.
Chemistry and physics of lipids 1996;80(1-2):3-19.
1995: J Y Kwak; I Lopez; D J Uhlinger; Sung Ho Ryu; David J. Lambeth
RhoA and a cytosolic 50-kDa factor reconstitute GTP gamma S-dependent phospholipase D activity in human neutrophil subcellular fractions.
The Journal of biological chemistry 1995;270(45):27093-8.
1995: I Lopez; D J Burns; David J. Lambeth
Regulation of phospholipase D by protein kinase C in human neutrophils. Conventional isoforms of protein kinase C phosphorylate a phospholipase D-related component in the plasma membrane.
The Journal of biological chemistry 1995;270(33):19465-72.
1995: Yukio Nisimoto; H Otsuka-Murakami; David J. Lambeth
Reconstitution of flavin-depleted neutrophil flavocytochrome b558 with 8-mercapto-FAD and characterization of the flavin-reconstituted enzyme.
The Journal of biological chemistry 1995;270(27):16428-34.
1995: David J. Lambeth; J Y Kwak; E P Bowman; D Perry; D J Uhlinger; I Lopez
ADP-ribosylation factor functions synergistically with a 50-kDa cytosolic factor in cell-free activation of human neutrophil phospholipase D.
The Journal of biological chemistry 1995;270(6):2431-4.
1995: D J Uhlinger; S R Tyagi; David J. Lambeth
On the mechanism of inhibition of the neutrophil respiratory burst oxidase by a peptide from the C-terminus of the large subunit of cytochrome b558.
Biochemistry 1995;34(2):524-7.
1995: E P Bowman; D J Uhlinger; David J. Lambeth
Neutrophil phospholipase D: inhibition by Rho-GDP dissociation inhibitor and stimulation by small GTPase GDP dissociation stimulator.
Methods in enzymology 1995;256():246-56.
1994: J L Freeman; M L Kreck; D J Uhlinger; David J. Lambeth
Ras effector-homologue region on Rac regulates protein associations in the neutrophil respiratory burst oxidase complex.
Biochemistry 1994;33(45):13431-5.
1994: D J Uhlinger; K L Taylor; David J. Lambeth
p67-phox enhances the binding of p47-phox to the human neutrophil respiratory burst oxidase complex.
The Journal of biological chemistry 1994;269(35):22095-8.
1994: M L Kreck; D J Uhlinger; S R Tyagi; K L Inge; David J. Lambeth
Participation of the small molecular weight GTP-binding protein Rac1 in cell-free activation and assembly of the respiratory burst oxidase. Inhibition by a carboxyl-terminal Rac peptide.
The Journal of biological chemistry 1994;269(6):4161-8.
1993: D K Perry; Victoria L Stevens; T S Widlanski; David J. Lambeth
A novel ecto-phosphatidic acid phosphohydrolase activity mediates activation of neutrophil superoxide generation by exogenous phosphatidic acid.
The Journal of biological chemistry 1993;268(34):25302-10.
1993: E P Bowman; D J Uhlinger; David J. Lambeth
Neutrophil phospholipase D is activated by a membrane-associated Rho family small molecular weight GTP-binding protein.
The Journal of biological chemistry 1993;268(29):21509-12.
1993: Victoria L Stevens; T Xu; David J. Lambeth
Cholesterol trafficking in steroidogenic cells. Reversible cycloheximide-dependent accumulation of cholesterol in a pre-steroidogenic pool.
European journal of biochemistry / FEBS 1993;216(2):557-63.
1993: D J Uhlinger; S R Tyagi; K L Inge; David J. Lambeth
The respiratory burst oxidase of human neutrophils. Guanine nucleotides and arachidonate regulate the assembly of a multicomponent complex in a semirecombinant cell-free system.
The Journal of biological chemistry 1993;268(12):8624-31.
1992: D K Perry; W L Hand; Dale E Edmondson; David J. Lambeth
Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2749-58.
1992: D J Uhlinger; K L Inge; M L Kreck; S R Tyagi; N Neckelmann; David J. Lambeth
Reconstitution and characterization of the human neutrophil respiratory burst oxidase using recombinant p47-phox, p67-phox and plasma membrane.
Biochemical and biophysical research communications 1992;186(1):509-16.
1992: S R Tyagi; D J Uhlinger; David J. Lambeth; C Champagne; T E Van Dyke
Altered diacylglycerol level and metabolism in neutrophils from patients with localized juvenile periodontitis.
Infection and immunity 1992;60(6):2481-7.
1992: M Tamura; M Takeshita; J T Curnutte; D J Uhlinger; David J. Lambeth
Stabilization of human neutrophil NADPH oxidase activated in a cell-free system by cytosolic proteins and by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide.
The Journal of biological chemistry 1992;267(11):7529-38.
1992: S R Tyagi; N Neckelmann; D J Uhlinger; D N Burnham; David J. Lambeth
Cell-free translocation of recombinant p47-phox, a component of the neutrophil NADPH oxidase: effects of guanosine 5'-O-(3-thiotriphosphate), diacylglycerol, and an anionic amphiphile.
Biochemistry 1992;31(10):2765-74.
1992: Victoria L Stevens; T Xu; David J. Lambeth
Cholesterol pools in rat adrenal mitochondria: use of cholesterol oxidase to infer a complex pool structure.
Endocrinology 1992;130(3):1557-63.
1991: D J Uhlinger; D N Burnham; David J. Lambeth
Nucleoside triphosphate requirements for superoxide generation and phosphorylation in a cell-free system from human neutrophils. Sodium dodecyl sulfate and diacylglycerol activate independently of protein kinase C.
The Journal of biological chemistry 1991;266(31):20990-7.
1991: S C Olson; E P Bowman; David J. Lambeth
Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.
The Journal of biological chemistry 1991;266(26):17236-42.
1991: D J Uhlinger; D N Burnham; R E Mullins; J R Kalmar; C W Cutler; Roland R Arnold; David J. Lambeth; Alfred H Merrill
Functional differences in human neutrophils isolated pre- and post-prandially.
FEBS letters 1991;286(1-2):28-32.
1991: T S Xu; E P Bowman; D B Glass; David J. Lambeth
Stimulation of adrenal mitochondrial cholesterol side-chain cleavage by GTP, steroidogenesis activator polypeptide (SAP), and sterol carrier protein2. GTP and SAP act synergistically.
The Journal of biological chemistry 1991;266(11):6801-7.
1991: S R Tyagi; S C Olson; D N Burnham; David J. Lambeth
Cyclic AMP-elevating agents block chemoattractant activation of diradylglycerol generation by inhibiting phospholipase D activation.
The Journal of biological chemistry 1991;266(6):3498-504.
1991: D B Glass; D G Robertson; T S Xu; E P Bowman; David J. Lambeth
Chemical synthesis, initial conformational studies, and activity of rat steroidogenesis activator peptide and a truncated analog.
Endocrine research 1991;17(1-2):307-26.
1991: D G Robertson; D Perry; David J. Lambeth
Inhibition of mitochondrial cholesterol side-chain cleavage by structural analogs of cholesterol sulfate.
Endocrine research 1991;17(1-2):297-306.
1990: S C Olson; S R Tyagi; David J. Lambeth
Fluoride activates diradylglycerol and superoxide generation in human neutrophils via PLD/PA phosphohydrolase-dependent and -independent pathways.
FEBS letters 1990;272(1-2):19-24.
1990: D N Burnham; D J Uhlinger; David J. Lambeth
Diradylglycerol synergizes with an anionic amphiphile to activate superoxide generation and phosphorylation of p47phox in a cell-free system from human neutrophils.
The Journal of biological chemistry 1990;265(29):17550-9.
1989: M Tamura; T Tamura; D N Burnham; D J Uhlinger; David J. Lambeth
Stabilization of the superoxide-generating respiratory burst oxidase of human neutrophil plasma membrane by crosslinking with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide.
Archives of biochemistry and biophysics 1989;275(1):23-32.
1989: Xiangxi Xu; T S Xu; D G Robertson; David J. Lambeth
GTP stimulates pregnenolone generation in isolated rat adrenal mitochondria.
The Journal of biological chemistry 1989;264(30):17674-80.
1989: S R Tyagi; Elliott F Winton; David J. Lambeth
Granulocyte/macrophage colony-stimulating factor primes human neutrophils for increased diacylglycerol generation in response to chemoattractant.
FEBS letters 1989;257(1):188-90.
1989: S R Tyagi; D N Burnham; David J. Lambeth
On the biological occurrence and regulation of 1-acyl and 1-O-alkyl-diradylglycerols in human neutrophils. Selective destruction of diacyl species using Rhizopus lipase.
The Journal of biological chemistry 1989;264(22):12977-82.
1989: Xiangxi Xu; David J. Lambeth
Cholesterol sulfate is a naturally occurring inhibitor of steroidogenesis in isolated rat adrenal mitochondria.
The Journal of biological chemistry 1989;264(13):7222-7.
1989: D G Robertson; M DiGirolamo; Alfred H Merrill; David J. Lambeth
Insulin-stimulated hexose transport and glucose oxidation in rat adipocytes is inhibited by sphingosine at a step after insulin binding.
The Journal of biological chemistry 1989;264(12):6773-9.
1989: Alfred H Merrill; S Nimkar; D Menaldino; Yusuf A Hannun; C Loomis; R M Bell; S R Tyagi; David J. Lambeth; Victoria L Stevens; R Hunter
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds.
Biochemistry 1989;28(8):3138-45.
1989: D N Burnham; S R Tyagi; D J Uhlinger; David J. Lambeth
Diacylglycerol generation and phosphoinositide turnover in human neutrophils: effects of particulate versus soluble stimuli.
Archives of biochemistry and biophysics 1989;269(1):345-53.
1989: David J. Lambeth; Xiangxi Xu
Cholesterol sulfate: a naturally-occurring inhibitor of cholesterol side-chain cleavage which functions at the level of intramitochondrial cholesterol translocation.
Endocrine research 1989;15(1-2):85-99.
1988: David J. Lambeth
Introduction: respiratory burst oxidase and its regulation.
Journal of bioenergetics and biomembranes 1988;20(6):633-5.
1988: David J. Lambeth
Activation of the respiratory burst oxidase in neutrophils: on the role of membrane-derived second messengers, Ca++, and protein kinase C.
Journal of bioenergetics and biomembranes 1988;20(6):709-33.
1988: M Tamura; T Tamura; S R Tyagi; David J. Lambeth
The superoxide-generating respiratory burst oxidase of human neutrophil plasma membrane. Phosphatidylserine as an effector of the activated enzyme.
The Journal of biological chemistry 1988;263(33):17621-6.
1988: S R Tyagi; M Tamura; D N Burnham; David J. Lambeth
Phorbol myristate acetate (PMA) augments chemoattractant-induced diglyceride generation in human neutrophils but inhibits phosphoinositide hydrolysis. Implications for the mechanism of PMA priming of the respiratory burst.
The Journal of biological chemistry 1988;263(26):13191-8.
1988: Yukio Nisimoto; M Tamura; David J. Lambeth
A menadione-stimulated pyridine nucleotide oxidase from resting bovine neutrophil membranes. Purification, properties, and immunochemical cross-reactivity with the human neutrophil NADPH oxidase.
The Journal of biological chemistry 1988;263(24):11657-63.
1988: W T Fowler; David J. Lambeth; G L Powell
Photoreactive cardiolipin analogues.
Chemistry and physics of lipids 1988;47(4):261-71.
1988: E Wilson; Elaine Wang; R E Mullins; D J Uhlinger; Dennis C Liotta; David J. Lambeth; Alfred H Merrill
Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.
The Journal of biological chemistry 1988;263(19):9304-9.
1988: David J. Lambeth; D N Burnham; S R Tyagi
Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. Delivery of sphinganine with bovine serum albumin minimizes cytotoxicity without affecting inhibition of the respiratory burst.
The Journal of biological chemistry 1988;263(8):3818-22.
1987: E Wilson; William G Rice; J M Kinkade; Alfred H Merrill; Roland R Arnold; David J. Lambeth
Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils.
Archives of biochemistry and biophysics 1987;259(1):204-14.
1987: E Deli; Z Kiss; E Wilson; David J. Lambeth; J F Kuo
Immunocytochemical localization of protein kinase C in resting and activated human neutrophils.
FEBS letters 1987;221(2):365-9.
1987: J Tuls; L Geren; David J. Lambeth; Francis Millett
The use of a specific fluorescence probe to study the interaction of adrenodoxin with adrenodoxin reductase and cytochrome P-450scc.
The Journal of biological chemistry 1987;262(21):10020-5.
1987: David J. Lambeth; Xiangxi Xu; M Glover
Cholesterol sulfate inhibits adrenal mitochondrial cholesterol side chain cleavage at a site distinct from cytochrome P-450scc. Evidence for an intramitochondrial cholesterol translocator.
The Journal of biological chemistry 1987;262(19):9181-8.
1987: E Wilson; Scott M Laster; Linda R Gooding; David J. Lambeth
Platelet-derived growth factor stimulates phagocytosis and blocks agonist-induced activation of the neutrophil oxidative burst: a possible cellular mechanism to protect against oxygen radical damage.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2213-7.
1987: Diane L Tribble; M R Glover; David J. Lambeth
Pregnenolone production by adrenal mitochondria: a new high-performance liquid chromatographic analytical method for cholesterol side-chain cleavage.
Journal of chromatography 1987;414(2):411-6.
1986: E Wilson; M C Olcott; R M Bell; Alfred H Merrill; David J. Lambeth
Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.
The Journal of biological chemistry 1986;261(27):12616-23.
1986: V L Stevens; David J. Lambeth; Alfred H Merrill
Use of cytochrome P-450scc to measure cholesterol-lipid interactions.
Biochemistry 1986;25(15):4287-92.
1986: B L Heyl; D J Tyrrell; David J. Lambeth
Cytochrome P-450scc-substrate interactions. Role of the 3 beta- and side chain hydroxyls in binding to oxidized and reduced forms of the enzyme.
The Journal of biological chemistry 1986;261(6):2743-9.
1986: Yukio Nisimoto; E Wilson; B L Heyl; David J. Lambeth
NADH dehydrogenase from bovine neutrophil membranes. Purification and properties.
The Journal of biological chemistry 1986;261(1):285-90.
1986: David J. Lambeth
Cytochrome P-450scc a review of the specificity and properties of the cholesterol binding site.
Endocrine research 1986;12(4):371-92.
1985: V L Stevens; Diane L Tribble; David J. Lambeth
Regulation of mitochondrial compartment volumes in rat adrenal cortex by ether stress.
Archives of biochemistry and biophysics 1985;242(1):324-7.
1985: Yukio Nisimoto; David J. Lambeth
NADPH-cytochrome P-450 reductase-cytochrome b5 interactions: crosslinking of the phospholipid vesicle-associated proteins by a water-soluble carbodiimide.
Archives of biochemistry and biophysics 1985;241(2):386-96.
1985: David J. Lambeth; S Kriengsiri
Cytochrome P-450scc-adrenodoxin interactions. Ionic effects on binding, and regulation of cytochrome reduction by bound steroid substrates.
The Journal of biological chemistry 1985;260(15):8810-6.
1985: H Kamin; C Batie; David J. Lambeth; J Lancaster; L Graham; John Salerno
Paramagnetic probes of multicomponent electron-transfer systems.
Biochemical Society transactions 1985;13(3):615-8.
1984: S O Pember; B L Heyl; J M Kinkade; David J. Lambeth
Cytochrome b558 from (bovine) granulocytes. Partial purification from Triton X-114 extracts and properties of the isolated cytochrome.
The Journal of biological chemistry 1984;259(16):10590-5.
1984: David J. Lambeth; L M Geren; Francis Millett
Adrenodoxin interaction with adrenodoxin reductase and cytochrome P-450scc. Cross-linking of protein complexes and effects of adrenodoxin modification by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.
The Journal of biological chemistry 1984;259(16):10025-9.
1984: V L Stevens; T Y Aw; Dean P Jones; David J. Lambeth
Oxygen dependence of adrenal cortex cholesterol side chain cleavage. Implications in the rate-limiting steps in steroidogenesis.
The Journal of biological chemistry 1984;259(2):1174-9.
1984: David J. Lambeth; V L Stevens
Cytochrome P-450scc: enzymology, and the regulation of intramitochondrial cholesterol delivery to the enzyme.
Endocrine research 1984;10(3-4):283-309.
1983: G V Vahouny; R Chanderbhan; B J Noland; D Irwin; P Dennis; David J. Lambeth; T J Scallen
Sterol carrier protein2. Identification of adrenal sterol carrier protein2 and site of action for mitochondrial cholesterol utilization.
The Journal of biological chemistry 1983;258(19):11731-7.
1983: David J. Lambeth; S O Pember
Cytochrome P-450scc-adrenodoxin complex. Reduction properties of the substrate-associated cytochrome and relation of the reduction states of heme and iron-sulfur centers to association of the proteins.
The Journal of biological chemistry 1983;258(9):5596-602.
1983: David J. Lambeth
22-Ketocholesterol. A potent competitive inhibitor of cytochrome P-450scc-dependent side-chain cleavage of cholesterol.
Molecular pharmacology 1983;23(3):743-7.
1983: S O Pember; G L Powell; David J. Lambeth
Cytochrome P-450scc-phospholipid interactions. Evidence for a cardiolipin binding site and thermodynamics of enzyme interactions with cardiolipin, cholesterol, and adrenodoxin.
The Journal of biological chemistry 1983;258(5):3198-206.
1982: David J. Lambeth; D W Seybert; J R Lancaster; John Salerno; H Kamin
Steroidogenic electron transport in adrenal cortex mitochondria.
Molecular and cellular biochemistry 1982;45(1):13-31.
1982: R E Kramer; R N Du Bois; E R Simpson; C M Anderson; K Kashiwagi; David J. Lambeth; C R Jefcoate; M R Waterman
Cell-free synthesis of precursor forms of mitochondrial steroid hydroxylase enzymes of the bovine adrenal cortex.
Archives of biochemistry and biophysics 1982;215(2):478-85.
1982: David J. Lambeth; S E Kitchen; A A Farooqui; Robert Tuckey; H Kamin
Cytochrome P-450scc-substrate interactions. Studies of binding and catalytic activity using hydroxycholesterols.
The Journal of biological chemistry 1982;257(4):1876-84.
1981: David J. Lambeth
Cytochrome P-450scc. Cardiolipin as an effector of activity of a mitochondrial cytochrome P-450.
The Journal of biological chemistry 1981;256(10):4757-62.
1981: David J. Lambeth; J R Lancaster; H Kamin
Steroidogenic electron transport by adrenodoxin reductase and adrenodoxin. Use of acetylated cytochrome c as a mechanistic probe of electron transfer.
The Journal of biological chemistry 1981;256(8):3674-8.
1981: Raymond DuBois; E R Simpson; J Tuckey; David J. Lambeth; M R Waterman
Evidence for a higher molecular weight precursor of cholesterol side-chain-cleavage cytochrome P-450 and induction of mitochondrial and cytosolic proteins by corticotropin in adult bovine adrenal cells.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(2):1028-32.
1981: Alfred H Merrill; David J. Lambeth; Dale E Edmondson; D B McCormick
Formation and mode of action of flavoproteins.
Annual review of nutrition 1981;1():281-317.
1980: David J. Lambeth; H Kamin; D W Seybert
Phosphatidylcholine vesicle reconstituted cytochrome P-450scc. Role of the membrane in control of activity and spin state of the cytochrome.
The Journal of biological chemistry 1980;255(17):8282-8.
1980: David J. Lambeth; D W Seybert; H Kamin
Adrenodoxin reductase . adrenodoxin complex. Rapid formation and breakdown of the complex and a slow conformational change in the flavoprotein.
The Journal of biological chemistry 1980;255(10):4667-72.
1980: C L Hall; David J. Lambeth
Studies on electron transfer from general acyl-CoA dehydrogenase to electron transfer flavoprotein.
The Journal of biological chemistry 1980;255(8):3591-5.
1980: David J. Lambeth; D W Seybert; H Kamin
Phospholipid vesicle-reconstituted cytochrome P-450SCC. Mutually facilitated binding of cholesterol and adrenodoxin.
The Journal of biological chemistry 1980;255(1):138-43.
1979: D W Seybert; J R Lancaster; David J. Lambeth; H Kamin
Participation of the membrane in the side chain cleavage of cholesterol. Reconstitution of cytochrome P-450scc into phospholipid vesicles.
The Journal of biological chemistry 1979;254(23):12088-98.
1979: David J. Lambeth; D W Seybert; H Kamin
Ionic effects on adrenal steroidogenic electron transport. The role of adrenodoxin as an electron shuttle.
The Journal of biological chemistry 1979;254(15):7255-64.
1979: David J. Lambeth; H Kamin
Adrenodoxin reductase.adrenodoxin complex. Flavin to iron-sulfur electron transfer as the rate-limiting step in the NADPH-cytochrome c reductase reaction.
The Journal of biological chemistry 1979;254(8):2766-74.
1979: C L Hall; David J. Lambeth; H Kamin
Acyl-CoA complexes of general acyl-CoA dehydrogenase and electron transfer flavoprotein.
The Journal of biological chemistry 1979;254(6):2023-31.
1978: D W Seybert; David J. Lambeth; H Kamin
The participation of a second molecule of adrenodoxin in cytochrome P-450-catalyzed 11beta hydroxylation.
The Journal of biological chemistry 1978;253(23):8355-8.
1977: David J. Lambeth; H Kamin
Adrenodoxin reductase and adrenodoxin. Mechanisms of reduction of ferricyanide and cytochrome c.
The Journal of biological chemistry 1977;252(9):2908-17.
1976: David J. Lambeth; D R McCaslin; H Kamin
Adrenodoxin reductase-adrenodexin complex.
The Journal of biological chemistry 1976;251(23):7545-50.
1976: David J. Lambeth; H Kamin
Adrenodoxin reductase. Properties of the complexes of reduced enzyme with NADP+ and NADPH.
The Journal of biological chemistry 1976;251(14):4299-306.
1973: R W Estabrook; J I Mason; J Baron; David J. Lambeth; M Waterman
Drugs, alcohol and sex hormones: a molecular perspective of the receptivity of cytochrome P-450.
Annals of the New York Academy of Sciences 1973;212():27-49.