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Wetzler Lee

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TOP 3
Deana N Toussi; Wetzler Lee; Margaretha Carraway; Lisa A Lewis; Xiuping Liu; Paola Massari
The amino acid sequence of Neisseria lactamica PorB surface-exposed loops influences Toll-like receptor 2-dependent cell activation.
Laura Oliveira-Nascimento; Paola Massari; Wetzler Lee
The Role of TLR2 in Infection and Immunity.
Paola Massari; Wetzler Lee
Analysis of parameters associated with prevention of cellular apoptosis by pathogenic Neisseriae and purified porins.

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All Publications

2012: Deana N Toussi; Wetzler Lee; Margaretha Carraway; Lisa A Lewis; Xiuping Liu; Paola Massari
The amino acid sequence of Neisseria lactamica PorB surface-exposed loops influences Toll-like receptor 2-dependent cell activation.
Infection and immunity 2012;80(10):3417-28.
2012: Laura Oliveira-Nascimento; Paola Massari; Wetzler Lee
The Role of TLR2 in Infection and Immunity.
Frontiers in immunology 2012;3():79.
2012: Paola Massari; Wetzler Lee
Analysis of parameters associated with prevention of cellular apoptosis by pathogenic Neisseriae and purified porins.
Methods in molecular biology (Clifton, N.J.) 2012;799():319-41.
2010: Xiuping Liu; Wetzler Lee; Laura Oliveira Nascimento; Paola Massari
Human airway epithelial cell responses to Neisseria lactamica and purified porin via Toll-like receptor 2-dependent signaling.
Infection and immunity 2010;78(12):5314-23.
2010: Wetzler Lee
Innate immune function of the neisserial porins and the relationship to vaccine adjuvant activity.
Future microbiology 2010;5(5):749-58.
2010: Paola Massari; Jay Gunawardana; Xiuping Liu; Wetzler Lee
Meningococcal porin PorB prevents cellular apoptosis in a toll-like receptor 2- and NF-kappaB-independent manner.
Infection and immunity 2010;78(3):994-1003.
2010: Damiana Chiavolini; Javier Rangel Moreno; Gretchen Berg; Kate Christian; Laura Oliveira-Nascimento; Susan Weir; Joseph Alroy; Troy D Randall; Wetzler Lee
Bronchus-associated lymphoid tissue (BALT) and survival in a vaccine mouse model of tularemia.
PloS one 2010;5(6):e11156.
2009: S A Follows; J Murlidharan; P Massari; Wetzler Lee; Caroline Attardo Genco
Neisseria gonorrhoeae infection protects human endocervical epithelial cells from apoptosis via expression of host antiapoptotic proteins.
Infection and immunity 2009;77(9):3602-10.
2008: Damiana Chiavolini; Susan Weir; John R Murphy; Wetzler Lee
Neisseria meningitidis PorB, a Toll-like receptor 2 ligand, improves the capacity of Francisella tularensis lipopolysaccharide to protect mice against experimental tularemia.
Clinical and vaccine immunology : CVI 2008;15(9):1322-9.
2008: Heather Macleod; Navneet Bhasin; Wetzler Lee
Role of protein tyrosine kinase and Erk1/2 activities in the Toll-like receptor 2-induced cellular activation of murine B cells by neisserial porin.
Clinical and vaccine immunology : CVI 2008;15(4):630-7.
2008: Xiuping Liu; Wetzler Lee; Paola Massari
The PorB porin from commensal Neisseria lactamica induces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant.
Vaccine 2008;26(6):786-96.
2008: Damiana Chiavolini; Joseph Alroy; Carol A King; Peter Jorth; Susan Weir; Guillermo Madico; John R Murphy; Wetzler Lee
Identification of immunologic and pathologic parameters of death versus survival in respiratory tularemia.
Infection and immunity 2008;76(2):486-96.
2007: Heather Macleod; Wetzler Lee
T cell activation by TLRs: a role for TLRs in the adaptive immune response.
Science's STKE : signal transduction knowledge environment 2007;2007(402):pe48.
2007: Jennifer M Burke; Lisa M Ganley-Leal; Asma Khatri; Wetzler Lee
Neisseria meningitidis PorB, a TLR2 ligand, induces an antigen-specific eosinophil recall response: potential adjuvant for helminth vaccines?
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3222-30.
2007: Aletta C Schnitzler; Jennifer M Burke; Wetzler Lee
Induction of cell signaling events by the cholera toxin B subunit in antigen-presenting cells.
Infection and immunity 2007;75(6):3150-9.
2006: Lisa M Ganley-Leal; Xiuping Liu; Wetzler Lee
Toll-like receptor 2-mediated human B cell differentiation.
Clinical immunology (Orlando, Fla.) 2006;120(3):272-84.
2006: Paola Massari; Alberto Visintin; Jay Gunawardana; Kristen A Halmen; Carol A King; Douglas T Golenbock; Wetzler Lee
Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2373-80.
2005: Patricia Ayala; J Scott Wilbur; Wetzler Lee; John A Tainer; Aurelie Snyder; Magdalene So
The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca(2+) transients in infected epithelial cells.
Cellular microbiology 2005;7(12):1736-48.
2005: Paola Massari; Carol A King; Heather Macleod; Wetzler Lee
Improved purification of native meningococcal porin PorB and studies on its structure/function.
Protein expression and purification 2005;44(2):136-46.
2005: Sarika Agarwal; Carol A King; Ellen K Klein; David E Soper; Peter A Rice; Wetzler Lee; Caroline Attardo Genco
The gonococcal Fur-regulated tbpA and tbpB genes are expressed during natural mucosal gonococcal infection.
Infection and immunity 2005;73(7):4281-7.
2005: Theresa E Singleton; Paola Massari; Wetzler Lee
Neisserial porin-induced dendritic cell activation is MyD88 and TLR2 dependent.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3545-50.
2003: Wetzler Lee
The role of Toll-like receptor 2 in microbial disease and immunity.
Vaccine 2003;21 Suppl 2():S55-60.
2003: Paola Massari; Sanjay Ram; Heather Macleod; Wetzler Lee
The role of porins in neisserial pathogenesis and immunity.
Trends in microbiology 2003;11(2):87-93.
2003: Paola Massari; Carol A King; Alan Yu Ho; Wetzler Lee
Neisserial PorB is translocated to the mitochondria of HeLa cells infected with Neisseria meningitidis and protects cells from apoptosis.
Cellular microbiology 2003;5(2):99-109.
2002: Paola Massari; Philipp Henneke; Yu Ho; Eicke Latz; Douglas T Golenbock; Wetzler Lee
Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1533-7.
2001: N Bhasin; Yu Ho; Wetzler Lee
Neisseria meningitidis lipopolysaccharide modulates the specific humoral immune response to neisserial porins but has no effect on porin-induced upregulation of costimulatory ligand B7-2.
Infection and immunity 2001;69(8):5031-6.
2001: Paola Massari; Wetzler Lee
Studies on the effect of neisserial porins on apoptosis of Mammalian cells.
Methods in molecular medicine 2001;67():587-97.
2000: Elisabeth Wedege; Karin Bolstad; Wetzler Lee; Hilde-Kari Guttormsen
IgG antibody levels to meningococcal porins in patient sera: comparison of immunoblotting and ELISA measurements.
Journal of immunological methods 2000;244(1-2):9-15.
2000: Paola Massari; Yu Ho; Wetzler Lee
Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9070-5.
1999: Sanjay Ram; F G Mackinnon; Sunita Gulati; DP McQuillen; U Vogel; M Frosch; Christopher Elkins; Hilde-Kari Guttormsen; Wetzler Lee; M Oppermann; MK Pangburn; Peter A Rice
The contrasting mechanisms of serum resistance of Neisseria gonorrhoeae and group B Neisseria meningitidis.
Molecular immunology 1999;36(13-14):915-28.
1999: S D Simpson; Yu Ho; Peter A Rice; Wetzler Lee
T lymphocyte response to Neisseria gonorrhoeae porin in individuals with mucosal gonococcal infections.
The Journal of infectious diseases 1999;180(3):762-73.
1999: F G Mackinnon; Yu Ho; Milan S Blake; Francis Michon; A Chandraker; M H Sayegh; Wetzler Lee
The role of B/T costimulatory signals in the immunopotentiating activity of neisserial porin.
The Journal of infectious diseases 1999;180(3):755-61.
1999: AK Lehmann; A Halstensen; Ingeborg S Aaberge; Johan Holst; Terje E Michaelsen; S Sornes; Wetzler Lee; Hilde-Kari Guttormsen
Human opsonins induced during meningococcal disease recognize outer membrane proteins PorA and PorB.
Infection and immunity 1999;67(5):2552-60.
1999: Fredrik Oftung; Lisbeth M Naess; Wetzler Lee; Gro Ellen Korsvold; Audun Aase; E Arne Høiby; R Dalseg; Johan Holst; Terje E Michaelsen; Bjørn Haneberg
Antigen-specific T-cell responses in humans after intranasal immunization with a meningococcal serogroup B outer membrane vesicle vaccine.
Infection and immunity 1999;67(2):921-7.
1998: A Z Henriksen; Johan A Maeland; Wetzler Lee
An epitope shared by enterobacterial and neisserial porin proteins.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1998;106(8):818-24.
1998: Hilde-Kari Guttormsen; Wetzler Lee; R W Finberg; Dennis L Kasper
Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer model.
Infection and immunity 1998;66(5):2026-32.
1998: Lisbeth M Naess; Fredrik Oftung; Audun Aase; Wetzler Lee; Randi H Sandin; Terje E Michaelsen
Human T-cell responses after vaccination with the Norwegian group B meningococcal outer membrane vesicle vaccine.
Infection and immunity 1998;66(3):959-65.
1997: Clifford M Snapper; FR Rosas; Marilyn R Kehry; James J Mond; Wetzler Lee
Neisserial porins may provide critical second signals to polysaccharide-activated murine B cells for induction of immunoglobulin secretion.
Infection and immunity 1997;65(8):3203-8.
1996: MJ Gill; DP McQuillen; J P van Putten; Wetzler Lee; J Bramley; H Crooke; N J Parsons; Jeffrey A Cole; Harry Smith
Functional characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae.
Infection and immunity 1996;64(8):3374-8.
1996: Wetzler Lee; Yu Ho; H Reiser; L W Wetzler
Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate.
The Journal of experimental medicine 1996;183(3):1151-9.
1995: Milan S Blake; Wetzler Lee
Vaccines for gonorrhea: where are we on the curve?
Trends in microbiology 1995;3(12):469-74.
1995: R Bjerknes; Hilde-Kari Guttormsen; C O Solberg; Wetzler Lee
Neisserial porins inhibit human neutrophil actin polymerization, degranulation, opsonin receptor expression, and phagocytosis but prime the neutrophils to increase their oxidative burst.
Infection and immunity 1995;63(1):160-7.
1994: Peter A Rice; DP McQuillen; Sunita Gulati; D B Jani; Wetzler Lee; Milan S Blake; Emil C Gotschlich
Serum resistance of Neisseria gonorrhoeae. Does it thwart the inflammatory response and facilitate the transmission of infection?
Annals of the New York Academy of Sciences 1994;730():7-14.
1994: Wetzler Lee
Immunopotentiating ability of neisserial major outer membrane proteins. Use as an adjuvant for poorly immunogenic substances and potential use in vaccines.
Annals of the New York Academy of Sciences 1994;730():367-70.
1994: Hilde-Kari Guttormsen; Wetzler Lee; C O Solberg
Humoral immune response to class 1 outer membrane protein during the course of meningococcal disease.
Infection and immunity 1994;62(4):1437-43.
1993: Hilde-Kari Guttormsen; Wetzler Lee; A Naess
Humoral immune response to the class 3 outer membrane protein during the course of meningococcal disease.
Infection and immunity 1993;61(11):4734-42.
1992: Wetzler Lee; Milan S Blake; K Barry; Emil C Gotschlich
Gonococcal porin vaccine evaluation: comparison of Por proteosomes, liposomes, and blebs isolated from rmp deletion mutants.
The Journal of infectious diseases 1992;166(3):551-5.
1992: Wetzler Lee; K Barry; Milan S Blake; Emil C Gotschlich
Gonococcal lipooligosaccharide sialylation prevents complement-dependent killing by immune sera.
Infection and immunity 1992;60(1):39-43.
1989: Wetzler Lee; Emil C Gotschlich; Milan S Blake; J M Koomey
The construction and characterization of Neisseria gonorrhoeae lacking protein III in its outer membrane.
The Journal of experimental medicine 1989;169(6):2199-209.
1989: Milan S Blake; Wetzler Lee; Emil C Gotschlich; Peter A Rice
Protein III: structure, function, and genetics.
Clinical microbiology reviews 1989;2 Suppl():S60-3.
1989: Wetzler Lee; Milan S Blake; Emil C Gotschlich
Protein I (Por) of Neisseria gonorrhoeae as an immunogen: liposomes, proteosomes, and the lack of blocking antibodies.
Transactions of the Association of American Physicians 1989;102():78-90.
1989: Milan S Blake; Wetzler Lee; Emil C Gotschlich; Peter A Rice
Developing a gonococcal protein I vaccine.
Advances in experimental medicine and biology 1989;251():315-27.
1988: Wetzler Lee; Milan S Blake; Emil C Gotschlich
Characterization and specificity of antibodies to protein I of Neisseria gonorrhoeae produced by injection with various protein I-adjuvant preparations.
The Journal of experimental medicine 1988;168(5):1883-97.