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Ray Schinazi

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Hongwang Zhang; Longhu Zhou; Franck Amblard; Drew R Bobeck; Steven J Coats; Tamara R McBrayer; Junxing Shi; Sijia Tao; Phillip M Tharnish; Tony Whitaker; Ray F Schinazi
Synthesis and evaluation of novel potent HCV NS5A inhibitors.
Christal D Sohl; Masanori Baba; William C Copeland; Rajesh Kasiviswanathan; Jiae Kim; Hiroaki Mitsuya; Ugo Pradere; Ray F Schinazi; Karen S Anderson
Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.
Jiae Kim; Yongfeng Li; Dennis C Liotta; Vinayaka R Prasad; Ray F Schinazi; Ligong Wang; Kimberlynne D Becnel; Kathleen M Frey; Scott J Garforth; Karen S Anderson
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase.

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2012: Hongwang Zhang; Longhu Zhou; Franck Amblard; Drew R Bobeck; Steven J Coats; Tamara R McBrayer; Junxing Shi; Sijia Tao; Phillip M Tharnish; Tony Whitaker; Ray F Schinazi
Synthesis and evaluation of novel potent HCV NS5A inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(14):4864-8.
2012: Christal D Sohl; Masanori Baba; William C Copeland; Rajesh Kasiviswanathan; Jiae Kim; Hiroaki Mitsuya; Ugo Pradere; Ray F Schinazi; Karen S Anderson
Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase.
Molecular pharmacology 2012;82(1):125-33.
2012: Jiae Kim; Yongfeng Li; Dennis C Liotta; Vinayaka R Prasad; Ray F Schinazi; Ligong Wang; Kimberlynne D Becnel; Kathleen M Frey; Scott J Garforth; Karen S Anderson
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry letters 2012;22(12):4064-7.
2012: Junxing Shi; Phillip M Tharnish; Tony Whitaker; Hongwang Zhang; Longhu Zhou; Franck Amblard; Drew R Bobeck; LAVANYA BONDADA; Steven J Coats; Peng Liu; Tamara R McBrayer; Ray F Schinazi
Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(10):3488-91.
2012: Christophe Vanpouille; Jan Balzarini; Marco Derudas; Jean-Charles Grivel; Andrea Introini; Andrea Lisco; Christopher McGuigan; Melanie Merbah; Arshi Munawwar; Ray F Schinazi; Leonid Margolis
Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin.
Antimicrobial agents and chemotherapy 2012;56(5):2604-11.
2012: Seth C Kalichman; Denise White; Angela M Caliendo; Chauncey Cherry; Mervi Detorio; Miche'l Jones; Moira Kalichman; Ray F Schinazi
Use of dietary supplements among people living with HIV/AIDS is associated with vulnerability to medical misinformation on the internet.
AIDS research and therapy 2012;9(1):1.
2012: Brian D Herman; John W Mellors; Steven J Coats; Mervi Detorio; Hong-wang Zhang; Ugo Pradère; Richard Stanton; Ray F Schinazi; James H Nettles; Aleksandr Obikhod; Nicolas Sluis-Cremer
Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs.
Nucleic acids research 2012;40(1):381-90.
2011: Junxing Shi; Tony Whitaker; Hongwang Zhang; Longhu Zhou; Leda Bassit; Steven J Coats; Mervi Detorio; Matthias Götte; Melissa Johns; Tamara R McBrayer; Megan H Powdrill; Ray F Schinazi
Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates.
Bioorganic & medicinal chemistry letters 2011;21(23):7094-8.
2011: Hong-wang Zhang; Longhu Zhou; Phillip M Tharnish; Tony Whitaker; Sarah A Amichai; LAVANYA BONDADA; Steven J Coats; Mervi Detorio; Melissa D Johns; Tamara R McBrayer; Ray F Schinazi
Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.
Bioorganic & medicinal chemistry letters 2011;21(22):6788-92.
2011: Selwyn J Hurwitz; Ray F Schinazi
In silico study supports the efficacy of a reduced dose regimen for stavudine.
Antiviral research 2011;92(2):372-7.
2011: Hong-Wang Zhang; Nicolas Sluis-Cremer; Sarah Solomon; Si-Jia Tao; Leda Bassit; Steven J Coats; Mervi Detorio; Brian D Herman; John W Mellors; James H Nettles; Aleksandr Obikhod; Ray F Schinazi
Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides.
European journal of medicinal chemistry 2011;46(9):3832-44.
2011: Seth C Kalichman; Jennifer Pellowski; Angela M Caliendo; Chauncey Cherry; Mervi Detorio; Moira Kalichman; Ray F Schinazi
Food insufficiency and medication adherence among people living with HIV/AIDS in urban and peri-urban settings.
Prevention science : the official journal of the Society for Prevention Research 2011;12(3):324-32.
2011: Jeffrey D Meteer; Ray F Schinazi; Nicolas Sluis-Cremer; Sarah Solomon; Hong-wang Zhang; Ghazia Asif; Steven J Coats; Mervi Detorio; Dianna Koontz; John W Mellors
The base component of 3'-azido-2',3'-dideoxynucleosides influences resistance mutations selected in HIV-1 reverse transcriptase.
Antimicrobial agents and chemotherapy 2011;55(8):3758-64.
2011: Seth C Kalichman; Denise White; Angela M Caliendo; Charsey Cherry; Mervi Detorio; Tamar Grebler; Miche'l Jones; Moira Kalichman; Ray F Schinazi
Sexual HIV transmission and antiretroviral therapy: a prospective cohort study of behavioral risk factors among men and women living with HIV/AIDS.
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 2011;42(1):111-9.
2011: Edward M Kennedy; Waaqo Daddacha; Emilie Fromentin; Christina Gavegnano; Ray F Schinazi; Rebecca Slater; Baek Kim
Abundant non-canonical dUTP found in primary human macrophages drives its frequent incorporation by HIV-1 reverse transcriptase.
The Journal of biological chemistry 2011;286(28):25047-55.
2011: Ray F Schinazi; Ivana Massud; Kimberly L Rapp; Meta Cristiano; Mervi A Detorio; Richard A Stanton; Matthew A Bennett; Monique Kierlin-Duncan; Johan Lennerstrand; James H Nettles
Selection and characterization of HIV-1 with a novel S68 deletion in reverse transcriptase.
Antimicrobial agents and chemotherapy 2011;55(5):2054-60.
2011: Vincent Roy; Aleksandr Obikhod; Hong-Wang Zhang; Steven J Coats; Brian D Herman; Nicolas Sluis-Cremer; Luigi A Agrofoglio; Ray F Schinazi
Synthesis and anti-HIV evaluation of 3'-triazolo nucleosides.
Nucleosides, nucleotides & nucleic acids 2011;30(4):264-70.
2011: Horrick Sharma; Shivaputra Patil; Tino W Sanchez; Nouri Neamati; Ray F Schinazi; John K Buolamwini
Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry 2011;19(6):2030-45.
2011: Ting Nie; Mervi Detorio; Ray F Schinazi
Universal profiling of HIV-1 pol for genotypic study and resistance analysis across subtypes.
Antiviral therapy 2011;16(8):1267-75.
2011: Noortje M van Maarseveen; Jori Symons; Joop E Arends; Greg L Beilhartz; Dorien de Jong; Matthias Götte; Andy Im Hoepelman; Aleksandr Obikhod; Marieke Pingen; Ray F Schinazi; Sijia Tao; Monique Nijhuis
Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans.
Antiviral therapy 2011;16(7):1123-30.
2011: Ray F Schinazi
William H Prusoff dies at 90 - a renaissance man that revolutionized the treatment of herpesviruses and HIV.
Antiviral chemistry & chemotherapy 2011;21(6):219-20.
2011: Jesse D Deere; Ray F Schinazi; Thomas W North
Simian immunodeficiency virus macaque models of HIV latency.
Current opinion in HIV and AIDS 2011;6(1):57-61.
2010: Tatiana Rodríguez-Pérez; Susana Fernández; Yogesh S Sanghvi; Mervi Detorio; Ray F Schinazi; Vicente Gotor; Miguel Ferrero
Chemoenzymatic syntheses and anti-HIV-1 activity of glucose-nucleoside conjugates as prodrugs.
Bioconjugate chemistry 2010;21(12):2239-49.
2010: Edward M Kennedy; Christina Gavegnano; Laura Nguyen; Rebecca Slater; Amanda Lucas; Emilie Fromentin; Ray F Schinazi; Baek Kim
Ribonucleoside triphosphates as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophages.
The Journal of biological chemistry 2010;285(50):39380-91.
2010: Charlotte Charpentier; Lucile Larrouy; Gilles Collin; Florence Damond; sophie matheron; Geneviève Chêne; Ting Nie; Ray F Schinazi; Françoise Brun-Vézinet; Diane Descamps
In-vitro phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitor S/GSK1349572.
AIDS (London, England) 2010;24(17):2753-5.
2010: Seth C Kalichman; Christina Amaral; Connie Swetsze; Lisa Eaton; Moira Kalichman; Charsey Cherry; Mervi Detorio; Angela M Caliendo; Ray F Schinazi
Monthly unannounced pill counts for monitoring HIV treatment adherence: tests for self-monitoring and reactivity effects.
HIV clinical trials 2010;11(6):325-31.
2010: Jay Lin; Vincent Roy; Liya Wang; Li You; Luigi A Agrofoglio; Dominique Deville-Bonne; Tamara R McBrayer; Steven J Coats; Ray F Schinazi; Staffan Eriksson
3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.
Bioorganic & medicinal chemistry 2010;18(9):3261-9.
2010: MinKyun Na; Yuanqing Ding; Bin Wang; Babu L Tekwani; Ray F Schinazi; Scott Franzblau; Michelle Kelly; Robert Stone; Xing-Cong Li; Daneel Ferreira; Mark T Hamann
Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia.
Journal of natural products 2010;73(3):383-7.
2010: Emilie Fromentin; Christina Gavegnano; Aleksandr Obikhod; Ray F Schinazi
Simultaneous quantification of intracellular natural and antiretroviral nucleosides and nucleotides by liquid chromatography-tandem mass spectrometry.
Analytical chemistry 2010;82(5):1982-9.
2010: Selwyn J Hurwitz; Ghazia Asif; Emilie Fromentin; Phillip M Tharnish; Ray F Schinazi
Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals.
Antimicrobial agents and chemotherapy 2010;54(3):1248-55.
2010: Thomas W North; Joanne Higgins; Jesse D Deere; Timothy L Hayes; Andradi Villalobos; Lourdes Adamson; Barbara L Shacklett; Ray F Schinazi; Paul A Luciw
Viral sanctuaries during highly active antiretroviral therapy in a nonhuman primate model for AIDS.
Journal of virology 2010;84(6):2913-22.
2010: Christophe Vanpouille; Andrea Lisco; Marco Derudas; Elisa Saba; Jean-Charles Grivel; Beda Brichacek; Francesca Scrimieri; Ray F Schinazi; Dominique Schols; Christopher McGuigan; Jan Balzarini; Leonid Margolis
A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2.
The Journal of infectious diseases 2010;201(4):635-43.
2010: Ray F Schinazi; Leda Bassit; C Gavegnano
HCV drug discovery aimed at viral eradication.
Journal of viral hepatitis 2010;17(2):77-90.
2010: Drew R Bobeck; Ray F Schinazi; Steven J Coats
Advances in nucleoside monophosphate prodrugs as anti-HCV agents.
Antiviral therapy 2010;15(7):935-50.
2010: Jesse D Deere; Joanne Higgins; Elda Cannavo; Andradi Villalobos; Lourdes Adamson; Emilie Fromentin; Ray F Schinazi; Paul A Luciw; Thomas W North
Viral decay kinetics in the highly active antiretroviral therapy-treated rhesus macaque model of AIDS.
PloS one 2010;5(7):e11640.
2010: Robert L Murphy; Nancy M Kivel; Carlos Zala; Claudia Ochoa; Phillip Tharnish; Judy Mathew; Maria Luz Pascual; Ray F Schinazi
Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV-1-infected individuals.
Antiviral therapy 2010;15(2):185-92.
2010: Ila R Singh; John E Gorzynski; Daria Drobysheva; Leda Bassit; Ray F Schinazi
Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome.
PloS one 2010;5(4):e9948.
2010: Hong-Wang Zhang; Steven J Coats; LAVANYA BONDADA; Franck Amblard; Mervi Detorio; Ghazia Asif; Emilie Fromentin; Sarah Solomon; Aleksandr Obikhod; Tony Whitaker; Nicolas Sluis-Cremer; John W Mellors; Ray F Schinazi
Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus.
Bioorganic & medicinal chemistry letters 2010;20(1):60-4.
2010: Peter William Krug; Ray F Schinazi; Julia Hilliard
Inhibition of B virus (Macacine herpesvirus 1) by conventional and experimental antiviral compounds.
Antimicrobial agents and chemotherapy 2010;54(1):452-9.
2009: Emilie Fromentin; Ghazia Asif; Aleksandr Obikhod; Selwyn J Hurwitz; Ray F Schinazi
Simultaneous quantification of 9-(beta-D-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography-tandem mass spectrometric assay.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(29):3482-8.
2009: Franck Amblard; Emilie Fromentin; Mervi Detorio; Alexander Obikhod; Kimberly L Rapp; Tamara R McBrayer; Tony Whitaker; Steven J Coats; Ray F Schinazi
Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.
European journal of medicinal chemistry 2009;44(10):3845-51.
2009: Egor P Tchesnokov; Aleksandr Obikhod; Ray F Schinazi; Matthias Götte
Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme.
The Journal of biological chemistry 2009;284(39):26439-46.
2009: Franck Amblard; Jong Hyun Cho; Ray F Schinazi
Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry.
Chemical reviews 2009;109(9):4207-20.
2009: Nicolas Sluis-Cremer; Dianna L Koontz; Leda Bassit; Brenda I Hernandez-Santiago; Mervi Detorio; Kimberly L Rapp; Franck Amblard; LAVANYA BONDADA; Jason Grier; Steven J Coats; Ray F Schinazi; John W Mellors
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Antimicrobial agents and chemotherapy 2009;53(9):3715-9.
2009: Prem L Sharma; James H Nettles; Anya Feldman; Kimberly Rapp; Ray F Schinazi
Comparative analysis of in vitro processivity of HIV-1 reverse transcriptases containing mutations 65R, 74V, 184V and 65R+74V.
Antiviral research 2009;83(3):317-23.
2009: Egor P Tchesnokov; Aleksandr Obikhod; Ivana Massud; Andrea Lisco; Christophe Vanpouille; Beda Brichacek; Jan Balzarini; Christopher McGuigan; Marco Derudas; Leonid Margolis; Ray F Schinazi; Matthias Götte
Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase.
The Journal of biological chemistry 2009;284(32):21496-504.
2009: Grigorii G Sivets; Elena N Kalinichenko; Igor Mikhailopulo; Mervi A Detorio; Tami R McBrayer; Tony Whitaker; Ray F Schinazi
Synthesis and antiviral activity of purine 2',3'-dideoxy-2',3'-difluoro-D-arabinofuranosyl nucleosides.
Nucleosides, nucleotides & nucleic acids 2009;28(5):519-36.
2009: Alba Díaz-Rodríguez; Yogesh S Sanghvi; Susana Fernández; Ray F Schinazi; Emmanuel A Theodorakis; Miguel Ferrero; Vicente Gotor
Synthesis and anti-HIV activity of conformationally restricted bicyclic hexahydroisobenzofuran nucleoside analogs.
Organic & biomolecular chemistry 2009;7(7):1415-23.
2009: Erik R Kline; Leda Bassit; Brenda I Hernandez-Santiago; Mervi A Detorio; Bill Liang; Dean J Kleinhenz; Erik R Walp; Sergey Dikalov; Dean P Jones; Ray F Schinazi; Roy L Sutliff
Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction.
Cardiovascular toxicology 2009;9(1):1-12.
2009: Yuzeng Liang; Ashoke Sharon; Jason P Grier; Kimberly L Rapp; Ray F Schinazi; Chung (David) K. Chu
5'-O-Aliphatic and amino acid ester prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine (DOT): synthesis, anti-HIV activity, cytotoxicity and stability studies.
Bioorganic & medicinal chemistry 2009;17(3):1404-9.
2009: Hyo-Joong Kim; Ashoke Sharon; Chandralata Bal; Jianing Wang; Madhan Allu; Zhuhui Huang; Michael G Murray; Leda Bassit; Ray F Schinazi; Brent E Korba; Chung (David) K. Chu
Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro.
Journal of medicinal chemistry 2009;52(1):206-13.
2009: Ramu Rondla; Steven J Coats; Tamara R McBrayer; Jason Grier; Melissa Johns; Phillip M Tharnish; Tony Whitaker; Longhu Zhou; Ray F Schinazi
Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.
Antiviral chemistry & chemotherapy 2009;20(2):99-106.
2009: Christina Gavegnano; Ray F Schinazi
Antiretroviral therapy in macrophages: implication for HIV eradication.
Antiviral chemistry & chemotherapy 2009;20(2):63-78.
2009: Ray F Schinazi; Steven J Coats; Leda C Bassit; Johan Lennerstrand; James Nettles; Selwyn J Hurwitz
Approaches for the development of antiviral compounds: the case of hepatitis C virus.
Handbook of experimental pharmacology 2009;(189):25-51.
2008: Egor P Tchesnokov; Aleksandr Obikhod; Ray F Schinazi; Matthias Götte
Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase.
The Journal of biological chemistry 2008;283(49):34218-28.
2008: Selwyn J Hurwitz; Ghazia Asif; Nancy M Kivel; Ray F Schinazi
Development of an optimized dose for coformulation of zidovudine with drugs that select for the K65R mutation using a population pharmacokinetic and enzyme kinetic simulation model.
Antimicrobial agents and chemotherapy 2008;52(12):4241-50.
2008: Andrea Lisco; Christophe Vanpouille; Egor P Tchesnokov; Jean-Charles Grivel; Angélique Biancotto; Beda Brichacek; Julie Elliott; Emilie Fromentin; Robin J Shattock; Peter A Anton; Robert J Gorelick; Jan Balzarini; Christopher McGuigan; Marco Derudas; Matthias Götte; Ray F Schinazi; Leonid Margolis
Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues.
Cell host & microbe 2008;4(3):260-70.
2008: Seth C Kalichman; Christina M Amaral; Charsey Cherry; Jody Flanagan; Howard Pope; Lisa Eaton; Moira Kalichman; Demetria Cain; Mervi Detorio; Angela Caliendo; Ray F Schinazi
Monitoring medication adherence by unannounced pill counts conducted by telephone: reliability and criterion-related validity.
HIV clinical trials 2008;9(5):298-308.
2008: Cihan Yurdaydin; Hakan Bozkaya; Oguz Onder; H Sentürk; H Karaaslan; M Akdoğan; Hülya Cetinkaya; Esra Erden; O Erkan-Esin; Kendal Yalçin; A Mithat Bozdayi; Ray F Schinazi; J L Gerin; O Uzunalimoğlu; Ali Ozden
Treatment of chronic delta hepatitis with lamivudine vs lamivudine + interferon vs interferon.
Journal of viral hepatitis 2008;15(4):314-21.
2008: John J Bowling; Hari K Pennaka; Kelly Ivey; Subagus Wahyuono; Michelle Kelly; Ray F Schinazi; Frederick A Valeriote; David E Graves; Mark T Hamann
Antiviral and anticancer optimization studies of the DNA-binding marine natural product aaptamine.
Chemical biology & drug design 2008;71(3):205-15.
2008: Robert A Domaoal; Moira McMahon; Chloe L Thio; Christopher M Bailey; Julian Tirado-Rives; Aleksander Obikhod; Mervi Detorio; Kimberly L Rapp; Robert Siliciano; Ray F Schinazi; Karen S Anderson
Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase.
The Journal of biological chemistry 2008;283(9):5452-9.
2008: J Gerardo García-Lerma; Ron A Otten; Shoukat H Qari; Eddie Jackson; Mian-Er Cong; Silvina Masciotra; Wei Luo; Caryn Kim; Debra R Adams; Michael Monsour; Jonathan Lipscomb; Jeffrey A Johnson; David Delinsky; Ray F Schinazi; Robert Janssen; Thomas M Folks; Walid Heneine
Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir.
PLoS medicine 2008;5(2):e28.
2008: Rafael Tamazyan; Ayvazyan Armen; Martirosyan Ashot; Gasparyan Sahak; Ray F Schinazi
1-Benzyl-2-(1H-indol-3-yl)-5-oxo-pyrrolidine-2-carbonitrile.
Acta crystallographica. Section E, Structure reports online 2008;64(Pt 2):o368.
2008: Leda Bassit; Jason Grier; Matthew Bennett; Ray F Schinazi
Combinations of 2'-C-methylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis C virus replicon system.
Antiviral chemistry & chemotherapy 2008;19(1):25-31.
2007: Stephan Menne; Ghazia Asif; Jannan Narayanasamy; Scott D Butler; Andrea L George; Selwyn J Hurwitz; Ray F Schinazi; Chung (David) K. Chu; Paul J Cote; John L Gerin; Bud C Tennant
Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection.
Antimicrobial agents and chemotherapy 2007;51(9):3177-84.
2007: Janarthanan Narayanasamy; Manik R Pullagurla; Ashoke Sharon; Jianing Wang; Ray F Schinazi; Chung (David) K. Chu
Synthesis and anti-HIV activity of (-)-beta-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (-)-beta-D-(2R,4R)-1,3-dioxolane guanosine (DXG) prodrugs.
Antiviral research 2007;75(3):198-209.
2007: Franck Amblard; Baskaran Govindarajan; Benjamin Lefkove; Kimberly L Rapp; Mervi Detorio; Jack L Arbiser; Ray F Schinazi
Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
Bioorganic & medicinal chemistry letters 2007;17(16):4428-31.
2007: Ghazia Asif; Selwyn J Hurwitz; Junxing Shi; Brenda I Hernandez-Santiago; Ray F Schinazi
Pharmacokinetics of the antiviral agent beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 2007;51(8):2877-82.
2007: Ghazia Asif; Selwyn J Hurwitz; Aleksandr Obikhod; David Delinsky; Janarthanan Narayanasamy; Chung (David) K. Chu; Harold M McClure; Ray F Schinazi
Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys.
Antimicrobial agents and chemotherapy 2007;51(7):2424-9.
2007: Yongfeng Li; Shuli Mao; Michael W Hager; Kimberlynne D Becnel; Ray F Schinazi; Dennis C Liotta
Synthesis and evaluation of 2'-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents.
Bioorganic & medicinal chemistry letters 2007;17(12):3398-401.
2007: Johan Lennerstrand; Chung (David) K. Chu; Ray F Schinazi
Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate.
Antimicrobial agents and chemotherapy 2007;51(6):2078-84.
2007: Brenda I Hernandez-Santiago; Judy S Mathew; Kim L Rapp; Jason Grier; Ray F Schinazi
Antiviral and cellular metabolism interactions between Dexelvucitabine and lamivudine.
Antimicrobial agents and chemotherapy 2007;51(6):2130-5.
2007: Jianing Wang; Yunho Jin; Kimberly L Rapp; Ray F Schinazi; Chung (David) K. Chu
D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance.
Journal of medicinal chemistry 2007;50(8):1828-39.
2007: Shivaputra Patil; Shantaram Kamath; Tino Sanchez; Nouri Neamati; Ray F Schinazi; John K Buolamwini
Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry 2007;15(3):1212-28.
2007: Eisuke Murakami; Haiying Bao; Mangala Ramesh; Tamara R McBrayer; Tony Whitaker; Holly M Micolochick Steuer; Ray F Schinazi; Lieven Stuyver; Aleksandr Obikhod; Michael J Otto; Phillip A Furman
Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.
Antimicrobial agents and chemotherapy 2007;51(2):503-9.
2007: Jagadeeshwar R Rao; Ray F Schinazi; Chung (David) K. Chu
Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides.
Bioorganic & medicinal chemistry 2007;15(2):839-46.
2007: Brenda I Hernandez-Santiago; Aleksandr Obikhod; Emilie Fromentin; Selwyn J Hurwitz; Ray F Schinazi
Short communication cellular pharmacology of 9-(beta-D-1,3-dioxolan-4-yl) guanine and its lack of drug interactions with zidovudine in primary human lymphocytes.
Antiviral chemistry & chemotherapy 2007;18(6):343-6.
2007: Selwyn J Hurwitz; Ghazia Asif; Ray F Schinazi
Development of a population simulation model for HIV monotherapy virological outcomes using lamivudine.
Antiviral chemistry & chemotherapy 2007;18(6):329-41.
2007: Mark A Feitelson; Marcia M Clayton; Bill Sun; Ray F Schinazi
Development of a novel mouse model to evaluate drug candidates against hepatitis B virus.
Antiviral chemistry & chemotherapy 2007;18(4):213-23.
2007: Adrian S Ray; Joy Y Feng; Eisuke Murakami; Chung (David) K. Chu; Ray F Schinazi; Karen S Anderson
Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma.
Antiviral chemistry & chemotherapy 2007;18(1):25-33.
2007: AJR Chun; Peiyuan Wang; Abdalla Hassan; Jinfa Du; Phillip M Tharnish; Eisuke Murakami; Lieven Stuyver; Michael J Otto; Ray F Schinazi; Kyoichi A Watanabe
Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.
Nucleosides, nucleotides & nucleic acids 2007;26(1):83-97.
2006: Waseem Gul; Nicholas Hammond; Muhammad Yousaf; John J Bowling; Ray F Schinazi; Susan S Wirtz; Garcia de Castro Andrews; Carmen Cuevas; Mark T Hamann
Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity.
Bioorganic & medicinal chemistry 2006;14(24):8495-505.
2006: Hongwang Zhang; Ray F Schinazi; Chung (David) K. Chu
Synthesis of neplanocin F analogues as potential antiviral agents.
Bioorganic & medicinal chemistry 2006;14(24):8314-22.
2006: Omar N Al Safarjalani; Reem H Rais; Junxing Shi; Ray F Schinazi; Fardos N M Naguib; Mahmoud el Kouni
Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor.
Cancer chemotherapy and pharmacology 2006;58(5):692-8.
2006: Ray F Schinazi; Brenda I Hernandez-Santiago; Selwyn J Hurwitz
Pharmacology of current and promising nucleosides for the treatment of human immunodeficiency viruses.
Antiviral research 2006;71(2-3):322-34.
2006: Franck Amblard; David Delinsky; Jack L Arbiser; Ray F Schinazi
Facile purification of honokiol and its antiviral and cytotoxic properties.
Journal of medicinal chemistry 2006;49(11):3426-7.
2006: Yuzeng Liang; Janarthanan Narayanasamy; Ray F Schinazi; Chung (David) K. Chu
Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies.
Bioorganic & medicinal chemistry 2006;14(7):2178-89.
2006: Jeremy L Clark; J Christian Mason; Laurent Hollecker; Lieven Stuyver; Phillip M Tharnish; Tamara R McBrayer; Michael J Otto; Phillip A Furman; Ray F Schinazi; Kyoichi A Watanabe
Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.
Bioorganic & medicinal chemistry letters 2006;16(6):1712-5.
2006: Hyunah Choo; Xin Chen; Vikas Yadav; Jianing Wang; Ray F Schinazi; Chung (David) K. Chu
Synthesis and anti-HIV activity of D- and L-thietanose nucleosides.
Journal of medicinal chemistry 2006;49(5):1635-47.
2006: Yuzeng Liang; Janarthanan Narayanasamy; Kim L Rapp; Ray F Schinazi; Chung (David) K. Chu
PAMAM dendrimers and branched polyethyleneglycol (nanoparticles) prodrugs of (-)-beta-D-(2R, 4R)-dioxolane-thymine (DOT) and their anti-HIV activity.
Antiviral chemistry & chemotherapy 2006;17(6):321-9.
2006: Lieven Stuyver; Tamara R McBrayer; Phillip M Tharnish; Jeremy Clark; Laurent Hollecker; Stefania Lostia; Tammy Nachman; Jason Grier; Matthew A Bennett; Meng-Yu Xie; Ray F Schinazi; John D Morrey; Justin L Julander; Phillip A Furman; Michael J Otto
Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.
Antiviral chemistry & chemotherapy 2006;17(2):79-87.
2005: Vanessa Escuret; Vincent Aucagne; Nicolas Joubert; David Durantel; Kimberly L Rapp; Ray F Schinazi; Fabien Zoulim; Luigi A Agrofoglio
Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: antiviral activity and cellular toxicity.
Bioorganic & medicinal chemistry 2005;13(21):6015-24.
2005: Peiyuan Wang; Jinfa Du; Suguna Rachakonda; AJR Chun; Phillip M Tharnish; Lieven Stuyver; Michael J Otto; Ray F Schinazi; Kyoichi A Watanabe
Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives.
Journal of medicinal chemistry 2005;48(20):6454-60.
2005: Casey Moore; Brenda I Hernández-Santiago; Selwyn J Hurwitz; Chalet Tan; Chris Wang; Ray F Schinazi
The boron-neutron capture agent beta-D-5-o-carboranyl-2'-deoxyuridine accumulates preferentially in dividing brain tumor cells.
Journal of neuro-oncology 2005;74(3):275-80.
2005: Jennifer L Hammond; Urvi M Parikh; Dianna L Koontz; Susan Schlueter-Wirtz; Chung (David) K. Chu; Holly Bazmi; Ray F Schinazi; John W Mellors
In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine.
Antimicrobial agents and chemotherapy 2005;49(9):3930-2.
2005: Kenneth Williams; Susan V Westmoreland; Jane B Greco; Eva M Ratai; Lentz Margaret; Woong-Ki Kim; Robert A Fuller; John P Kim; Patrick Autissier; Prabhat Sehgal; Ray F Schinazi; Norbert Bischofberger; Michael Piatak; Jeffrey D Lifson; Eliezer Masliah; R Gilberto González
Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.
The Journal of clinical investigation 2005;115(9):2534-45.
2005: Jeremy L Clark; Laurent Hollecker; J Christian Mason; Lieven Stuyver; Phillip M Tharnish; Stefania Lostia; Tamara R McBrayer; Ray F Schinazi; Kyoichi A Watanabe; Michael J Otto; Phillip A Furman; Wojciech J Stec; Steven E Patterson; Krzysztof W Pankiewicz
Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.
Journal of medicinal chemistry 2005;48(17):5504-8.
2005: Nicolas Sluis-Cremer; Dominique Arion; Urvi M Parikh; Dianna L Koontz; Ray F Schinazi; John W Mellors; Michael A Parniak
The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.
The Journal of biological chemistry 2005;280(32):29047-52.
2005: Michael J Moser; Meta Ruckstuhl; Christine A Larsen; Amanda J Swearingen; Miroslaw Kozlowski; Leda Bassit; Prem L Sharma; Ray F Schinazi; James R Prudent
Quantifying mixed populations of drug-resistant human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 2005;49(8):3334-40.
2005: Christian Herzmann; K Arastèh; R L Murphy; Hubert Schulbin; Peter Kreckel; D Drauz; Ray F Schinazi; A Beard; Leanne Cartee; Michael J Otto
Safety, pharmacokinetics, and efficacy of (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine with efavirenz and stavudine in antiretroviral-naïve human immunodeficiency virus-infected patients.
Antimicrobial agents and chemotherapy 2005;49(7):2828-33.
2005: S Balakrishna Pai; A Mithat Bozdayi; Rekha B Pai; Tolunay Beker; Mustafa Sarioglu; Ahmet R Turkyilmaz; Jason Grier; Cihan Yurdaydin; Ray F Schinazi
Emergence of a novel mutation in the FLLA region of hepatitis B virus during lamivudine therapy.
Antimicrobial agents and chemotherapy 2005;49(7):2618-24.
2005: Brenda I Hernandez-Santiago; Huachun Chen; Ghazia Asif; Thierry Beltran; Shuli Mao; Selwyn J Hurwitz; Jason Grier; Harold M McClure; Chung (David) K. Chu; Dennis C Liotta; Ray F Schinazi
Pharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeys.
Antimicrobial agents and chemotherapy 2005;49(7):2589-97.
2005: Zbigniew J Leśnikowski; Edyta Paradowska; Agnieszka B Olejniczak; Mirosława Studzińska; Petra Seekamp; Uw Schüssler; Detlef Gabel; Ray F Schinazi; Jaromir Plesek
Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates.
Bioorganic & medicinal chemistry 2005;13(13):4168-75.
2005: Chung (David) K. Chu; Vikas Yadav; Youhoon H Chong; Ray F Schinazi
Anti-HIV activity of (-)-(2R,4R)-1- (2-hydroxymethyl-1,3-dioxolan-4-yl)-thymine against drug-resistant HIV-1 mutants and studies of its molecular mechanism.
Journal of medicinal chemistry 2005;48(12):3949-52.
2005: Simona Rossi; Ray F Schinazi; Giacomo Martini
ESR as a valuable tool for the investigation of the dynamics of EPC and EPC/cholesterol liposomes containing a carboranyl-nucleoside intended for BNCT.
Biochimica et biophysica acta 2005;1712(1):81-91.
2005: Jianing Wang; Yunho Jin; Kimberly L Rapp; Matthew Bennett; Ray F Schinazi; Chung (David) K. Chu
Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides.
Journal of medicinal chemistry 2005;48(11):3736-48.
2005: Thomas W North; Koen K A Van Rompay; Joanne Higgins; Timothy B Matthews; Debra A Wadford; Niels C Pedersen; Ray F Schinazi
Suppression of virus load by highly active antiretroviral therapy in rhesus macaques infected with a recombinant simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.
Journal of virology 2005;79(12):7349-54.
2005: Omar N Al Safarjalani; Xiao-Jian Zhou; Reem H Rais; Junxing Shi; Ray F Schinazi; Fardos N M Naguib; Mahmoud el Kouni
5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens.
Cancer chemotherapy and pharmacology 2005;55(6):541-51.
2005: Adrian S Ray; Brenda I Hernandez-Santiago; Judy S Mathew; Eisuke Murakami; Carey Bozeman Clark; Meng-Yu Xie; Ginger E Dutschman; Elizabeth Gullen; Zhenjun Yang; Selwyn Hurwitz; Yung-Chi Cheng; Chung (David) K. Chu; Harold M McClure; Ray F Schinazi; Karen S Anderson
Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosine.
Antimicrobial agents and chemotherapy 2005;49(5):1994-2001.
2005: Urvi M Parikh; Dianna L Koontz; Chung (David) K. Chu; Ray F Schinazi; John W Mellors
In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase.
Antimicrobial agents and chemotherapy 2005;49(3):1139-44.
2005: Junxing Shi; Jinfa Du; Tianwei Ma; Krzysztof W Pankiewicz; Steven E Patterson; Phillip M Tharnish; Tamara R McBrayer; Lieven Stuyver; Michael J Otto; Chung (David) K. Chu; Ray F Schinazi; Kyoichi A Watanabe
Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.
Bioorganic & medicinal chemistry 2005;13(5):1641-52.
2005: Franck Amblard; Vincent Aucagne; Pierre Guenot; Ray F Schinazi; Luigi A Agrofoglio
Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series.
Bioorganic & medicinal chemistry 2005;13(4):1239-48.
2005: Kittisak Likhitwitayawuid; Boonchoo Sritularak; Kanokwan Benchanak; Vimolmas Lipipun; Judy Mathew; Ray F Schinazi
Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha.
Natural product research 2005;19(2):177-82.
2005: Ghazia Asif; Selwyn J Hurwitz; Giuseppe Gumina; Chung (David) K. Chu; Harold M McClure; Ray F Schinazi
Pharmacokinetics of the antiviral agent beta-L-3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 2005;49(2):560-4.
2005: Srinivas Gadthula; Chung (David) K. Chu; Ray F Schinazi
Synthesis and anti-HIV activity of beta-D-3'-azido-2',3'-unsaturated nucleosides and beta-D-3'-azido-3'-deoxyribofuranosylnucleosides.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1707-27.
2005: Abdalla E A Hassan; Peiyuan Wang; Tamara R McBrayer; Phillip M Tharnish; Lieven Stuyver; Michael J Otto; Kyoichi A Watanabe; Ray F Schinazi
Synthesis and anti-HCV activity of N9,5'-cyclo-3-(beta-D-ribofuranosyl)-8-azapurin-2-one derivatives.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1531-42.
2005: Abdalla E A Hassan; Peiyuan Wang; Tamara R McBrayer; Phillip M Tharnish; Lieven Stuyver; Ray F Schinazi; Michael J Otto; Kyoichi A Watanabe
Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3, 5'-anhydro-4-(beta-D-ribofuranosyl)-8-aza-purin-2-ones.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):961-4.
2005: Peiyuan Wang; Laurent Hollecker; Krzysztof W Pankiewicz; Steven E Patterson; Tony Whitaker; Tamara R McBrayer; Phillip M Tharnish; Lieven Stuyver; Ray F Schinazi; Michael J Otto; Kyoichi A Watanabe
Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):957-60.
2005: Junxing Shi; Jinfa Du; Tianwei Ma; Krzysztof W Pankiewicz; Steven E Patterson; Abdalla E A Hassan; Phillip M Tharnish; Tamara R McBrayer; Stefania Lostia; Lieven Stuyver; Kyoichi A Watanabe; Chung (David) K. Chu; Ray F Schinazi; Michael J Otto
Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):875-9.
2005: S Balakrishna Pai; Rekha B Pai; Meng-yu Xie; Tolunay Beker; Junxing Shi; Phillip M Tharnish; Chung (David) K. Chu; Ray F Schinazi
Characterization of hepatitis B virus inhibition by novel 2'-fluoro-2',3'-unsaturated beta-D- and L-nucleosides.
Antiviral chemistry & chemotherapy 2005;16(3):183-92.
2005: Prem L Sharma; Viktoria Nurpeisov; Ray F Schinazi
Retrovirus reverse transcriptases containing a modified YXDD motif.
Antiviral chemistry & chemotherapy 2005;16(3):169-82.
2005: Selwyn J Hurwitz; Michael J Otto; Ray F Schinazi
Comparative pharmacokinetics of Racivir, (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats, rabbits, dogs, monkeys and HIV-infected humans.
Antiviral chemistry & chemotherapy 2005;16(2):117-27.
2004: Brenda I Hernandez-Santiago; Thierry Beltran; Lieven Stuyver; Chung (David) K. Chu; Ray F Schinazi
Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells.
Antimicrobial agents and chemotherapy 2004;48(12):4636-42.
2004: Peiyuan Wang; Laurent Hollecker; Krzysztof W Pankiewicz; Steven E Patterson; Tony Whitaker; Tamara R McBrayer; Phillip M Tharnish; Robert W Sidwell; Lieven Stuyver; Michael J Otto; Ray F Schinazi; Kyoichi A Watanabe
Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.
Journal of medicinal chemistry 2004;47(24):6100-3.
2004: Shuli Mao; Martin Bouygues; Christopher Welch; Mirlinda Biba; Jen Chilenski; Ray F Schinazi; Dennis C Liotta
Synthesis of enantiomerically pure D-FDOC, an anti-HIV agent.
Bioorganic & medicinal chemistry letters 2004;14(19):4991-4.
2004: Xin Chen; Wen Zhou; Ray F Schinazi; Chung (David) K. Chu
Synthesis of 3'-fluoro-2',3'-dideoxy-2',3'-didehydro-4'-ethynyl-D- and -L-furanosyl nucleosides.
The Journal of organic chemistry 2004;69(18):6034-41.
2004: Michael J Hofman; Joanne Higgins; Timothy B Matthews; Niels C Pedersen; Chalet Tan; Ray F Schinazi; Thomas W North
Efavirenz therapy in rhesus macaques infected with a chimera of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 2004;48(9):3483-90.
2004: Lieven Stuyver; Tamara R McBrayer; Dirk Schürmann; Irena Kravec; Amanda Beard; Leanne Cartee; Ray F Schinazi; Abel De La Rosa; Robert L Murphy; Michael J Otto
Potent antiviral effect of reverset in HIV-1-infected adults following a single oral dose.
Antiviral therapy 2004;9(4):529-36.
2004: Karumanchi V Rao; Noer Kasanah; Subagus Wahyuono; Babu L Tekwani; Ray F Schinazi; Mark T Hamann
Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases.
Journal of natural products 2004;67(8):1314-8.
2004: LAVANYA BONDADA; Giuseppe Gumina; Ranjeet Nair; Xing Hai Ning; Ray F Schinazi; Chung (David) K. Chu
Synthesis of novel spiro[2.3]hexane carbocyclic nucleosides via enzymatic resolution.
Organic letters 2004;6(15):2531-4.
2004: Wen Zhou; Giuseppe Gumina; Youhoon Chong; Jianing Wang; Ray F Schinazi; Chung (David) K. Chu
Synthesis, structure-activity relationships, and drug resistance of beta-d-3'-fluoro-2',3'-unsaturated nucleosides as anti-HIV Agents.
Journal of medicinal chemistry 2004;47(13):3399-408.
2004: Junxing Shi; Adrian S Ray; Judy S Mathew; Karen S Anderson; Chung (David) K. Chu; Ray F Schinazi
2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions.
Bioorganic & medicinal chemistry letters 2004;14(9):2159-62.
2004: Prem L Sharma; Viktoria Nurpeisov; Kimberly Lee; Sara Skaggs; Christina Amat Di San Filippo; Ray F Schinazi
Replication-dependent 65R-->K reversion in human immunodeficiency virus type 1 reverse transcriptase double mutant K65R + L74V.
Virology 2004;321(2):222-34.
2004: Krzysztof W Pankiewicz; Steven E Patterson; Paul L Black; Hiremagalur N Jayaram; Dipesh Risal; Barry M Goldstein; Lieven Stuyver; Ray F Schinazi
Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.
Current medicinal chemistry 2004;11(7):887-900.
2004: Joy Y Feng; Eisuke Murakami; Suzana M Zorca; Allison A Johnson; Kenneth A Johnson; Ray F Schinazi; Phillip A Furman; Karen S Anderson
Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase.
Antimicrobial agents and chemotherapy 2004;48(4):1300-6.
2004: Eisuke Murakami; Adrian S Ray; Ray F Schinazi; Karen S Anderson
Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP.
Antiviral research 2004;62(1):57-64.
2004: Wei Zhu; Youhoon Chong; Hyunah Choo; Judy Mathews; Ray F Schinazi; Chung (David) K. Chu
Synthesis, structure-activity relationships, and mechanism of drug resistance of D- and L-beta-3'-fluoro-2',3'-unsaturated-4'-thionucleosides as anti-HIV agents.
Journal of medicinal chemistry 2004;47(7):1631-40.
2004: Lieven Stuyver; Tamara R McBrayer; Tony Whitaker; Phillip M Tharnish; Mangala Ramesh; Stefania Lostia; Leanne Cartee; Junxing Shi; Ann Hobbs; Ray F Schinazi; Kyoichi A Watanabe; Michael J Otto
Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.
Antimicrobial agents and chemotherapy 2004;48(2):651-4.
2004: Prem L Sharma; Viktoria Nurpeisov; Brenda I Hernandez-Santiago; Thierry Beltran; Ray F Schinazi
Nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase.
Current topics in medicinal chemistry 2004;4(9):895-919.
2004: Laurent Hollecker; Hyunah Choo; Youhoon Chong; Chung (David) K. Chu; Stefania Lostia; Tamara R McBrayer; Lieven Stuyver; J Christian Mason; Jinfa Du; Suguna Rachakonda; Junxing Shi; Ray F Schinazi; Kyochi A Watanabe
Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture.
Antiviral chemistry & chemotherapy 2004;15(1):43-55.
2004: Ray F Schinazi; Selwyn J Hurwitz; Irina Liberman; Yuliya Glazkova; Nicolas S Mourier; Jeffrey Olson; Thomas E Keane
Tissue disposition of 5-o-carboranyluracil--a novel agent for the boron neutron capture therapy of prostate cancer.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):291-306.
2004: Mark A Feitelson; Jonathan D Larkin; Ray F Schinazi
Hepatitis B virus transgenic severe combined immunodeficient mouse model of acute and chronic liver disease.
Methods in molecular medicine 2004;96():269-87.
2003: Jiangnan Peng; Jin-Feng Hu; Abul B Kazi; Ze Li; Mitchell Avery; Olivier Peraud; Russell T Hill; Scott Franzblau; Fangqiu Zhang; Ray F Schinazi; Susan S Wirtz; Phillip Tharnish; Michelle Kelly; Subagus Wahyuono; Mark T Hamann
Manadomanzamines A and B: a novel alkaloid ring system with potent activity against mycobacteria and HIV-1.
Journal of the American Chemical Society 2003;125(44):13382-6.
2003: Youhoon Chong; Lieven Stuyver; Michael J Otto; Ray F Schinazi; Chung (David) K. Chu
Mechanism of antiviral activities of 3'-substituted L-nucleosides against 3TC-resistant HBV polymerase: a molecular modelling approach.
Antiviral chemistry & chemotherapy 2003;14(6):309-19.
2003: Ray F Schinazi
Assessment of the relative potency of emtricitabine and lamivudine.
Journal of acquired immune deficiency syndromes (1999) 2003;34(2):243-5; author reply 245-6.
2003: Lieven Stuyver; Tamara R McBrayer; Phillip M Tharnish; Abdalla E A Hassan; Chung (David) K. Chu; Krzysztof W Pankiewicz; Kyochi A Watanabe; Ray F Schinazi; Michael J Otto
Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites.
Journal of virology 2003;77(19):10689-94.
2003: S Balakrishna Pai; Rekha B Pai; Ray F Schinazi
Treatment modalities for hepatitis B viral infection and resistance to antiviral therapy.
Panminerva medica 2003;45(3):165-73.
2003: Yoshio Saito; Vanessa Escuret; David Durantel; Fabien Zoulim; Ray F Schinazi; Luigi A Agrofoglio
Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon.
Bioorganic & medicinal chemistry 2003;11(17):3633-9.
2003: Deborah J Gochfeld; Khalid A El-Sayed; Muhammad Yousaf; Jin-Feng Hu; Piotr Bartyzel; D Chuck Dunbar; Scott P Wilkins; Jordan K Zjawiony; Ray F Schinazi; S Schlueter Wirtz; Phillip Tharnish; Mark T Hamann
Marine natural products as lead anti-HIV agents.
Mini reviews in medicinal chemistry 2003;3(5):401-24.
2003: Adrian S Ray; Eisuke Murakami; Aravind Basavapathruni; Joseph A Vaccaro; Dagny Ulrich; Chung (David) K. Chu; Ray F Schinazi; Karen S Anderson
Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis.
Biochemistry 2003;42(29):8831-41.
2003: Youhoon Chong; Giuseppe Gumina; Judy S Mathew; Ray F Schinazi; Chung (David) K. Chu
l-2',3'-Didehydro-2',3'-dideoxy-3'-fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance.
Journal of medicinal chemistry 2003;46(15):3245-56.
2003: A Mithat Bozdayi; O Uzunalimoğlu; A Resat Türkyilmaz; Nuray Aslan; Orhan Sezgin; Tülin Sahin; Gülendam Bozdayi; Kubilay Cinar; S Balakrishna Pai; R Pai; Hakan Bozkaya; Selim Karayalçin; Cihan Yurdaydin; Ray F Schinazi
YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine.
Journal of viral hepatitis 2003;10(4):256-65.
2003: Karumanchi V Rao; Bernard D Santarsiero; Andrew D Mesecar; Ray F Schinazi; Babu L Tekwani; Mark T Hamann
New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge.
Journal of natural products 2003;66(6):823-8.
2003: Huachun Chen; S Balakrishna Pai; Selwyn J Hurwitz; Chung (David) K. Chu; Yuliya Glazkova; Harold M McClure; Mark A Feitelson; Ray F Schinazi
Antiviral activity and pharmacokinetics of 1-(2,3-dideoxy-2-fluoro-beta-L-glyceropent-2-enofuranosyl)cytosine.
Antimicrobial agents and chemotherapy 2003;47(6):1922-8.
2003: Abdalla E A Hassan; Balakrina S Pai; Stefania Lostia; Lieven Stuyver; Michael J Otto; Ray F Schinazi; Kyoichi A Watanabe
Synthesis and antiviral evaluation of 2',3'-dideoxy-2'-fluoro-3'- C-hydroxymethyl-beta-D-arabinofuranosyl pyrimidine nucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):891-4.
2003: Youhoon Chong; Hyunah Choo; Ray F Schinazi; Chung (David) K. Chu
2'-Fluoro-4'-thio-2',3'-unsaturated nucleosides: anti-HIV activity, resistance profile, and molecular modeling studies.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):611-5.
2003: Adrian S Ray; Ray F Schinazi; Eisuke Murakami; Aravind Basavapathruni; Junxing Shi; Suzana M Zorca; Chung (David) K. Chu; Karen S Anderson
Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase.
Antiviral chemistry & chemotherapy 2003;14(3):115-25.
2003: Junxing Shi; Judy S Mathew; Phillip M Tharnish; Suguna Rachakonda; S Balakrishna Pai; Marjorie Adams; Jason Grier; Karen Gallagher; Hangchun Zhang; Jing-Tao Wu; Guoen Shi; Romas Geleziunas; Susan Erickson-Viitanen; Lieven Stuyver; Michael J Otto; Kyoichi A Watanabe; Ray F Schinazi
N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity.
Antiviral chemistry & chemotherapy 2003;14(2):81-90.
2003: Hyunah Choo; Youhoon Chong; Yongseok Choi; Judy Mathew; Ray F Schinazi; Chung (David) K. Chu
Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.
Journal of medicinal chemistry 2003;46(3):389-98.
2003: Romas Geleziunas; Karen Gallagher; Hangchun Zhang; Lee Bacheler; Sena Garber; Jing-Tao Wu; Guoen Shi; Michael J Otto; Ray F Schinazi; Susan Erickson-Viitanen
HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset).
Antiviral chemistry & chemotherapy 2003;14(1):49-59.
2003: Susan Erickson-Viitanen; Jing-Tao Wu; Guoen Shi; Steven Unger; Robert W King; Barbara Fish; Ronald Klabe; Romas Geleziunas; Karen Gallagher; Michael J Otto; Ray F Schinazi
Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV.
Antiviral chemistry & chemotherapy 2003;14(1):39-47.
2003: Lieven Stuyver; Tony Whitaker; Tamara R McBrayer; Brenda I Hernandez-Santiago; Stefania Lostia; Phillip M Tharnish; Mangala Ramesh; Chung (David) K. Chu; Robert Jordan; Junxing Shi; Suguna Rachakonda; Kyoichi A Watanabe; Michael J Otto; Ray F Schinazi
Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.
Antimicrobial agents and chemotherapy 2003;47(1):244-54.
2002: Ayse Kocabalkanli; Ray F Schinazi
Synthesis of oxathiolane imidazole nucleosides.
Farmaco (Società chimica italiana : 1989) 2002;57(12):993-7.
2002: Lieven Stuyver; Stefania Lostia; Marjorie Adams; Judy S Mathew; Balakrishna S Pai; Jason Grier; Phillip M Tharnish; Yongseok Choi; Youhoon Chong; Hyunah Choo; Chung (David) K. Chu; Michael J Otto; Ray F Schinazi
Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.
Antimicrobial agents and chemotherapy 2002;46(12):3854-60.
2002: Adrian S Ray; Eisuke Murakami; Celeste N Peterson; Junxing Shi; Ray F Schinazi; Karen S Anderson
Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase.
Antiviral research 2002;56(3):189-205.
2002: Selwyn J Hurwitz; Ray F Schinazi
Development of a pharmacodynamic model for HIV treatment with nucleoside reverse transcriptase and protease inhibitors.
Antiviral research 2002;56(2):115-27.
2002: Youhoon Chong; Hyunah Choo; Yongseok Choi; Judy Mathew; Ray F Schinazi; Chung (David) K. Chu
Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.
Journal of medicinal chemistry 2002;45(22):4888-98.
2002: Kathleen Tatti; Brent E Korba; Heather L Stang; Simon F Peek; John L Gerin; Bud C Tennant; Ray F Schinazi
Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine.
Antiviral research 2002;55(1):141-50.
2002: Seth C Kalichman; David Rompa; Maggi Cage; James Austin; Webster Luke; T Barnett; P Tharnish; J Mowrey; Ray F Schinazi
Sexual transmission risk perceptions and behavioural correlates of HIV concentrations in semen.
AIDS care 2002;14(3):343-9.
2002: Koen K A Van Rompay; Timothy B Matthews; Joanne Higgins; Don R Canfield; Ross P Tarara; Mark A Wainberg; Ray F Schinazi; Niels C Pedersen; Thomas W North
Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase.
Journal of virology 2002;76(12):6083-92.
2002: Selwyn J Hurwitz; Bud C Tennant; Brent E Korba; Irina Liberman; John L Gerin; Ray F Schinazi
Viral pharmacodynamic model for (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine (emtricitabine) in chronically infected woodchucks.
Antiviral chemistry & chemotherapy 2002;13(3):165-76.
2002: Xuefeng Liu; Ray F Schinazi
Hepatitis B virus resistance to lamivudine and its clinical implications.
Antiviral chemistry & chemotherapy 2002;13(3):143-55.
2002: Ray F Schinazi; John Mellors; Holly Bazmi; Sharon Diamond; Sena Garber; Karen Gallagher; Romas Geleziunas; Ronald Klabe; James Michael Pierce; Marlene Rayner; Jing-Tao Wu; Hangchun Zhang; Jennifer Hammond; Lee Bacheler; Douglas J Manion; Michael J Otto; Lieven Stuyver; George L Trainor; Dennis C Liotta; Susan Erickson-Viitanen
DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants.
Antimicrobial agents and chemotherapy 2002;46(5):1394-401.
2002: Adrian S Ray; Zhenjun Yang; Junxing Shi; Ann Hobbs; Ray F Schinazi; Chung (David) K. Chu; Karen S Anderson
Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate.
Biochemistry 2002;41(16):5150-62.
2002: Kyeong Lee; Yongseok Choi; Giuseppe Gumina; Wen Zhou; Ray F Schinazi; Chung (David) K. Chu
Structure-activity relationships of 2'-fluoro-2',3'-unsaturated D-nucleosides as anti-HIV-1 agents.
Journal of medicinal chemistry 2002;45(6):1313-20.
2002: Youhoon Chong; Katyna Borroto-Esoda; Phillip A Furman; Ray F Schinazi; Chung (David) K. Chu
Molecular mechanism of DApd/DXG against zidovudine- and lamivudine- drug resistant mutants: a molecular modelling approach.
Antiviral chemistry & chemotherapy 2002;13(2):115-28.
2002: Cecilia H Marzabadi; Richard W Franck; Ray F Schinazi
The synthesis and biological evaluation of novel bridging nucleoside analogues.
Bioorganic & medicinal chemistry 2002;10(2):273-81.
2002: Yongseok Choi; Hyunah Choo; Youhoon Chong; Sookwang Lee; Süreyya Olgen; Ray F Schinazi; Chung (David) K. Chu
Synthesis and potent anti-HIV activity of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine.
Organic letters 2002;4(2):305-7.
2001: Giuseppe Gumina; Ray F Schinazi; Chung (David) K. Chu
Synthesis and potent anti-HIV activity of L-3'-fluoro-2',3'-unsaturated cytidine.
Organic letters 2001;3(26):4177-80.
2001: Seth C Kalichman; Maggi Cage; T Barnett; P Tharnish; David Rompa; James Austin; Webster Luke; J O'Mowrey; Ray F Schinazi
Human immunodeficiency virus in semen and plasma: investigation of sexual transmission risk behavioral correlates.
AIDS research and human retroviruses 2001;17(18):1695-703.
2001: Gyu-Yong Song; V Paul; H Choo; J Morrey; R W Sidwell; Ray F Schinazi; Chung (David) K. Chu
Enantiomeric synthesis of D- and L-cyclopentenyl nucleosides and their antiviral activity against HIV and West Nile virus.
Journal of medicinal chemistry 2001;44(23):3985-93.
2001: Omar N Al Safarjalani; Xiao-Jian Zhou; Fardos N M Naguib; Junxing Shi; Ray F Schinazi; Mahmoud el Kouni
Enhancement of the bioavailability of oral uridine by coadministration of 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for uridine rescue regimens in chemotherapy.
Cancer chemotherapy and pharmacology 2001;48(5):389-97.
2001: Omar N Al Safarjalani; Xiao-Jian Zhou; Fardos N M Naguib; NM Goudgaon; Ray F Schinazi; Mahmoud el Kouni
Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy.
Cancer chemotherapy and pharmacology 2001;48(2):145-50.
2001: I Gay; Daniel R Lorey; Ray F Schinazi; GH Morrison; Subhash Chandra
Dynamic SIMS ion microscopy imaging of intracellular boron accumulation from carboranyl nucleosides in glioma cells.
Anticancer research 2001;21(4A):2369-75.
2001: Tedd V Ellerbrock; Jeffrey Lennox; KA Clancy; Ray F Schinazi; Thomas C Wright; Melody Pratt-Palmore; Tammy Evans-Strickfaden; Cathy Schnell; Rekha Pai; Lois J Conley; E E Parrish-Kohler; Timothy J Bush; Kathleen Tatti; Clyde E Hart
Cellular replication of human immunodeficiency virus type 1 occurs in vaginal secretions.
The Journal of infectious diseases 2001;184(1):28-36.
2001: ML Bryant; Edward Bridges; L Placidi; Abdesslem Faraj; Anna Giulia Loi; Claire Pierra; David Dukhan; Gilles Gosselin; Jean-Louis Imbach; B Hernandez; A Juodawlkis; Bud C Tennant; Brent E Korba; P Cote; Erika Cretton-Scott; Ray F Schinazi; Jean-Pierre Sommadossi
Anti-HBV specific beta-L-2'-deoxynucleosides.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):597-607.
2001: Junxing Shi; Ray F Schinazi
Asymmetric synthesis of carbocyclic pyrimidine nucleosides via pi-allylpalladium complex.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1367-70.
2001: L Placidi; Abdesslem Faraj; Anna Giulia Loi; Claire Pierra; David Egron; Erika Cretton-Scott; G Gosseli; Christian Périgaud; LT Martin; Ray F Schinazi; Jean-Louis Imbach; Mahmoud el Kouni; ML Bryant; Jean-Pierre Sommadossi
Antiviral activity and intracellular metabolism of bis(tButylSATE) phosphotriester of beta-L-2',3'dideoxyadenosine, a potent inhibitor of HIV and HBV replication.
Antiviral chemistry & chemotherapy 2001;12(2):99-108.
2001: Lieven Stuyver; S A Locarnini; Anna S F Lok; D D Richman; W F Carman; J L Dienstag; Ray F Schinazi
Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region.
Hepatology (Baltimore, Md.) 2001;33(3):751-7.
2001: D A Judd; James Nettles; Neysa Nevins; James P Snyder; Dennis C Liotta; Jordan Tang; J Ermolieff; Ray F Schinazi; Craig L Hill
Polyoxometalate HIV-1 protease inhibitors. A new mode of protease inhibition.
Journal of the American Chemical Society 2001;123(5):886-97.
2001: S K Ono; Nobumasa Kato; Yasushi Shiratori; J Kato; T Goto; Ray F Schinazi; Flair Jose Carrilho; Masao Omata
The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance.
The Journal of clinical investigation 2001;107(4):449-55.
2001: Ray F Schinazi; S Schlueter-Wirtz; Lieven Stuyver
Early detection of mixed mutations selected by antiretroviral agents in HIV-infected primary human lymphocytes.
Antiviral chemistry & chemotherapy 2001;12 Suppl 1():61-5.
2001: David Standring; Edward Bridges; L Placidi; Abdesslem Faraj; Anna Giulia Loi; Claire Pierra; David Dukhan; Gilles Gosselin; Jean-Louis Imbach; B Hernandez; A Juodawlkis; Bud C Tennant; Brent E Korba; P Cote; Erika Cretton-Scott; Ray F Schinazi; M Myers; ML Bryant; Jean-Pierre Sommadossi
Antiviral beta-L-nucleosides specific for hepatitis B virus infection.
Antiviral chemistry & chemotherapy 2001;12 Suppl 1():119-29.
2001: ML Bryant; Edward Bridges; L Placidi; Abdesslem Faraj; Anna Giulia Loi; Claire Pierra; David Dukhan; Gilles Gosselin; Jean-Louis Imbach; B Hernandez; A Juodawlkis; Bud C Tennant; Brent E Korba; P Cote; P Marion; Erika Cretton-Scott; Ray F Schinazi; Jean-Pierre Sommadossi
Antiviral L-nucleosides specific for hepatitis B virus infection.
Antimicrobial agents and chemotherapy 2001;45(1):229-35.
2001: Phillip A Furman; Jerry L Jeffrey; L L Kiefer; Joy Y Feng; Karen S Anderson; Katyna Borroto-Esoda; E Hill; W C Copeland; Chung (David) K. Chu; J P Sommadossi; I Liberman; Ray F Schinazi; George Painter
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.
Antimicrobial agents and chemotherapy 2001;45(1):158-65.
2000: Peter R Meyer; Suzanne E Matsuura; Ray F Schinazi; Antero G So; Walter A Scott
Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates.
Antimicrobial agents and chemotherapy 2000;44(12):3465-72.
2000: Chung (David) K. Chu; L Ma; Süreyya Olgen; C Pierra; J Du; Giuseppe Gumina; Elizabeth Gullen; Yung-Chi Cheng; Ray F Schinazi
Synthesis and antiviral activity of oxaselenolane nucleosides.
Journal of medicinal chemistry 2000;43(21):3906-12.
2000: Mahmoud el Kouni; NM Goudgaon; M Rafeeq; Omar N Al Safarjalani; Ray F Schinazi; Fardos N M Naguib
5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase.
Biochemical pharmacology 2000;60(6):851-6.
2000: OM Ashour; Fardos N M Naguib; NM Goudgaon; Ray F Schinazi; Mahmoud el Kouni
Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2'-deoxyuridine against murine colon tumor C26-10.
Biochemical pharmacology 2000;60(5):687-92.
2000: AJR Chun; Ray F Schinazi; Yung-Chi Cheng; Chung (David) K. Chu
Synthesis of 2',3'-dideoxy-3'-fluoro-L-ribonucleosides as potential antiviral agents from D-sorbitol.
Carbohydrate research 2000;328(1):49-59.
2000: J H Hong; M Y Gao; Yongseok Choi; Yung-Chi Cheng; Ray F Schinazi; Chung (David) K. Chu
Synthesis of novel 3'-C-methyl-apionucleosides: an asymmetric construction of a quaternary carbon by Claisen rearrangement.
Carbohydrate research 2000;328(1):37-48.
2000: Holly Bazmi; Jennifer L Hammond; S C Cavalcanti; Chung (David) K. Chu; Ray F Schinazi; John W Mellors
In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine.
Antimicrobial agents and chemotherapy 2000;44(7):1783-8.
2000: Brent E Korba; Ray F Schinazi; Paul J Cote; Bud C Tennant; John L Gerin
Effect of oral administration of emtricitabine on woodchuck hepatitis virus replication in chronically infected woodchucks.
Antimicrobial agents and chemotherapy 2000;44(6):1757-60.
2000: Samir A Ross; J D Weete; Ray F Schinazi; Susan S Wirtz; Phillip Tharnish; P J Scheuer; Mark T Hamann
Mololipids, a new series of anti-HIV bromotyramine-derived compounds from a sponge of the order verongida.
Journal of natural products 2000;63(4):501-3.
2000: L Placidi; Erika Cretton-Scott; Gilles Gosselin; Claire Pierra; Ray F Schinazi; Jean-Louis Imbach; Mahmoud el Kouni; Jean-Pierre Sommadossi
Intracellular metabolism of beta-L-2',3'-dideoxyadenosine: relevance to its limited antiviral activity.
Antimicrobial agents and chemotherapy 2000;44(4):853-8.
2000: Selwyn J Hurwitz; L Ma; A Eleuteri; J Wright; J Moravek; Ray F Schinazi
Cellular pharmacology of the D- and L-enantiomers of beta-5-o-carboranyl-2'-deoxyuridine.
Nucleosides, nucleotides & nucleic acids 2000;19(3):691-702.
2000: Ray F Schinazi; Selwyn J Hurwitz; Irina Liberman; AS Juodawlkis; Phillip Tharnish; J Shi; Dennis C Liotta; J A Coderre; Jeffrey Olson
Treatment of isografted 9L rat brain tumors with beta-5-o-carboranyl-2'-deoxyuridine neutron capture therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(2):725-30.
2000: George J Klarmann; RA Smith; Ray F Schinazi; Thomas W North; Bradley D Preston
Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site.
The Journal of biological chemistry 2000;275(1):359-66.
2000: P M Feorino; J D Williamson; Ray F Schinazi
Laboratory safety considerations.
Methods in molecular medicine 2000;24():13-25.
2000: OM Ashour; Fardos N M Naguib; NM Goudgaon; Ray F Schinazi; Mahmoud el Kouni
Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2',3',5'-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy.
Cancer chemotherapy and pharmacology 2000;46(3):235-40.
2000: OM Ashour; Omar N Al Safarjalani; Fardos N M Naguib; NM Goudgaon; Ray F Schinazi; Mahmoud el Kouni
Modulation of plasma uridine concentration by 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase: relevance to chemotherapy.
Cancer chemotherapy and pharmacology 2000;45(5):351-61.
2000: LT Martin; Erika Cretton-Scott; L Placidi; Abdesslem Faraj; Anna Giulia Loi; Ray F Schinazi; H M McClure; Gilles Gosselin; Jean-Louis Imbach; Jean-Pierre Sommadossi
In vitro and in vivo metabolism and pharmacokinetics of bis [(t-butyl)-S-acyl-2-thioethyl]-beta-L-2',3'-dideoxy-5-fluorocytidine monophosphate.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):481-99.
2000: C Pierra; Süreyya Olgen; S C Cavalcanti; Yung-Chi Cheng; Ray F Schinazi; Chung (David) K. Chu
Synthesis and antiviral activities of enantiomeric 1-[2-(hydroxymethyl) cyclopropyl] methyl nucleosides.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):253-68.
2000: Lieven Stuyver; Sija De Gendt; C Van Geyt; F Zoulim; M Fried; Ray F Schinazi; Rudi Rossau
A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness.
The Journal of general virology 2000;81(Pt 1):67-74.
2000: EA Gustafson; Ray F Schinazi; Joyce Diane Fingeroth
Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phosphorylates zidovudine but not ganciclovir.
Journal of virology 2000;74(2):684-92.
1999: H Chen; Ray F Schinazi; P Rajagopalan; Z Gao; Chung (David) K. Chu; H M McClure; F Douglas Boudinot
Pharmacokinetics of (-)-beta-D-dioxolane guanine and prodrug (-)-beta-D-2,6-diaminopurine dioxolane in rats and monkeys.
AIDS research and human retroviruses 1999;15(18):1625-30.
1999: N S Mourier; A Eleuteri; Selwyn J Hurwitz; Phillip Tharnish; Ray F Schinazi
Enantioselective synthesis and biological evaluation of 5-o-carboranyl pyrimidine nucleosides.
Bioorganic & medicinal chemistry 1999;7(12):2759-66.
1999: S C Cavalcanti; Y Xiang; MG Newton; Ray F Schinazi; Yung-Chi Cheng; Chung (David) K. Chu
Synthesis of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides as potential antiviral agents.
Nucleosides & nucleotides 1999;18(10):2233-52.
1999: Joy Y Feng; Junxing Shi; Ray F Schinazi; Karen S Anderson
Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(12):1511-7.
1999: P Wang; B Gullen; MG Newton; Yung-Chi Cheng; Ray F Schinazi; Chung (David) K. Chu
Asymmetric synthesis and antiviral activities of L-carbocyclic 2', 3'-didehydro-2',3'-dideoxy and 2',3'-dideoxy nucleosides.
Journal of medicinal chemistry 1999;42(17):3390-9.
1999: RA Smith; George J Klarmann; Kirsten M Stray; Uta K von Schwedler; Ray F Schinazi; Bradley D Preston; Thomas W North
A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidine.
Antimicrobial agents and chemotherapy 1999;43(8):2077-80.
1999: Ray F Schinazi; Ehud Ilan; P L Black; X Yao; Shlomo Dagan
Cell-based and animal models for hepatitis B and C viruses.
Antiviral chemistry & chemotherapy 1999;10(3):99-114.
1999: Kyeong Lee; Yongseok Choi; Elizabeth Gullen; S Schlueter-Wirtz; Ray F Schinazi; Yung-Chi Cheng; Chung (David) K. Chu
Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2', 3'-unsaturated L-nucleosides.
Journal of medicinal chemistry 1999;42(7):1320-8.
1999: Anna Giulia Loi; Abdesslem Faraj; Claire Pierra; Gilles Gosselin; Jean-Louis Imbach; S A Locarnini; E V Groman; Ray F Schinazi; Jean-Pierre Sommadossi
Comparison of anti-HBV activity of beta-D- and beta-L-DDA-5'monophosphate prodrugs and effectiveness in combination with lamivudine.
Nucleosides & nucleotides 1999;18(4-5):1005-6.
1999: Abdesslem Faraj; L Placidi; C Perigaud; Erika Cretton-Scott; Gilles Gosselin; LT Martin; Claire Pierra; Ray F Schinazi; Jean-Louis Imbach; Jean-Pierre Sommadossi
Intracellular metabolism of beta-L-ddAMP-bis(tbutylSATE), a potent inhibitor of hepatitis B virus replication.
Nucleosides & nucleotides 1999;18(4-5):987-8.
1999: K Lee; Yongseok Choi; J H Hong; Ray F Schinazi; Chung (David) K. Chu
New classes of fluorinated L-nucleosides; synthesis and antiviral activity.
Nucleosides & nucleotides 1999;18(4-5):537-40.
1999: LT Martin; Erika Cretton-Scott; Ray F Schinazi; XJ Zhou; H M McClure; C Mathe; Gilles Gosselin; Jean-Louis Imbach; Jean-Pierre Sommadossi
Pharmacokinetics of beta-L-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1999;43(4):920-4.
1999: Clyde E Hart; Jeffrey Lennox; Melody Pratt-Palmore; Thomas C Wright; Ray F Schinazi; Tammy Evans-Strickfaden; Timothy J Bush; Cathy Schnell; Lois J Conley; KA Clancy; Tedd V Ellerbrock
Correlation of human immunodeficiency virus type 1 RNA levels in blood and the female genital tract.
The Journal of infectious diseases 1999;179(4):871-82.
1999: J Shi; J J McAtee; S Schlueter Wirtz; Phillip Tharnish; AS Juodawlkis; Dennis C Liotta; Ray F Schinazi
Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
Journal of medicinal chemistry 1999;42(5):859-67.
1999: L Ma; Selwyn J Hurwitz; J Shi; J J Mcatee; Dennis C Liotta; Harold M McClure; Ray F Schinazi
Pharmacokinetics of the antiviral agent beta-D-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1999;43(2):381-4.
1999: J Gerardo García-Lerma; Ray F Schinazi; A S Juodawlkis; Vincent Soriano; Y Lin; Kathleen Tatti; David Rimland; Thomas M Folks; Walid Heneine
A rapid non-culture-based assay for clinical monitoring of phenotypic resistance of human immunodeficiency virus type 1 to lamivudine (3TC).
Antimicrobial agents and chemotherapy 1999;43(2):264-70.
1999: Pin-Fang Lin; C J González; B Griffith; G Friedland; V Calvez; F Ferchal; Ray F Schinazi; D H Shepp; A B Ashraf; M A Wainberg; V Soriano; J W Mellors; Richard J Colonno
Stavudine resistance: an update on susceptibility following prolonged therapy.
Antiviral therapy 1999;4(1):21-8.
1998: Selwyn J Hurwitz; Bud C Tennant; Brent E Korba; John L Gerin; Ray F Schinazi
Pharmacodynamics of (-)-beta-2',3'-dideoxy-3'-thiacytidine in chronically virus-infected woodchucks compared to its pharmacodynamics in humans.
Antimicrobial agents and chemotherapy 1998;42(11):2804-9.
1998: P Wang; Ray F Schinazi; Chung (David) K. Chu
Asymmetric synthesis and anti-HIV activity of L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine.
Bioorganic & medicinal chemistry letters 1998;8(13):1585-8.
1998: J C Graciet; J Shi; Ray F Schinazi
Synthesis and biological properties of the four optical isomers of 5-o-carboranyl-2',3'-didehydro-2',3'-dideoxyuridine.
Nucleosides & nucleotides 1998;17(4):711-27.
1998: RA Smith; K M Remington; Bradley D Preston; Ray F Schinazi; Thomas W North
A novel point mutation at position 156 of reverse transcriptase from feline immunodeficiency virus confers resistance to the combination of (-)-beta-2',3'-dideoxy-3'-thiacytidine and 3'-azido-3'-deoxythymidine.
Journal of virology 1998;72(3):2335-40.
1998: X You; Ray F Schinazi; Michael J Arrowood; M Lejkowski; AS Juodawlkis; Jan R Mead
In-vitro activities of paromomycin and lasalocid evaluated in combination against Cryptosporidium parvum.
The Journal of antimicrobial chemotherapy 1998;41(2):293-6.
1998: D Pillay; Ray F Schinazi
Antiviral drug resistance: from the laboratory to the patient.
Antiviral therapy 1998;3(4):237.
1998: Ray F Schinazi; Z J Lesnikowski
Boron containing oligonucleotides.
Nucleosides & nucleotides 1998;17(1-3):635-47.
1997: Jodi B Black; D A Burns; C S Goldsmith; P M Feorino; K Kite-Powell; Ray F Schinazi; Peter William Krug; Philip E Pellett
Biologic properties of human herpesvirus 7 strain SB.
Virus research 1997;52(1):25-41.
1997: XR Pan-Zhou; Erika Cretton-Scott; XJ Zhou; MY Xie; Roger Rahmani; Ray F Schinazi; K Duchin; Jean-Pierre Sommadossi
Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes.
Antimicrobial agents and chemotherapy 1997;41(11):2502-10.
1997: Lakshmi P Kotra; Y Xiang; MG Newton; Ray F Schinazi; YC Cheng; Chung (David) K. Chu
Structure-activity relationships of 2'-deoxy-2',2'-difluoro-L-erythro-pentofuranosyl nucleosides.
Journal of medicinal chemistry 1997;40(22):3635-44.
1997: EJ McIntee; Rory P Remmel; Ray F Schinazi; T W Abraham; Carston R Wagner
Probing the mechanism of action and decomposition of amino acid phosphomonoester amidates of antiviral nucleoside prodrugs.
Journal of medicinal chemistry 1997;40(21):3323-31.
1997: J Du; S Surzhykov; J S Lin; MG Newton; YC Cheng; Ray F Schinazi; Chung (David) K. Chu
Synthesis, anti-human immunodeficiency virus and anti-hepatitis B virus activities of novel oxaselenolane nucleosides.
Journal of medicinal chemistry 1997;40(19):2991-3.
1997: YM Lin; H Anderson; Michael T Flavin; Y H Pai; E Mata-Greenwood; T Pengsuparp; J M Pezzuto; Ray F Schinazi; S H Hughes; FC Chen
In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.
Journal of natural products 1997;60(9):884-8.
1997: KK Manouilov; L S Manouilova; F Douglas Boudinot; Ray F Schinazi; Chung (David) K. Chu
Biotransformation and pharmacokinetics of prodrug 9-(beta-D-1,3-dioxolan-4-yl)-2-aminopurine and its antiviral metabolite 9-(beta-D-1,3-dioxolan-4-yl)guanine in mice.
Antiviral research 1997;35(3):187-93.
1997: KK Manouilov; Z S Xu; F Douglas Boudinot; Ray F Schinazi; Chung (David) K. Chu
Lymphatic targeting of anti-HIV nucleosides: distribution of 2',3'-dideoxyinosine after intravenous and oral administration of dipalmitoylphosphatidyl prodrug in mice.
Antiviral research 1997;34(3):91-9.
1997: H Chen; KK Manouilov; Chung (David) K. Chu; Ray F Schinazi; H M McClure; F Douglas Boudinot
High-performance liquid chromatographic determination of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane, and their metabolite (-)-beta-D-dioxolane guanine in monkey serum, urine and cerebrospinal fluid.
Journal of chromatography. B, Biomedical sciences and applications 1997;691(2):425-32.
1997: Dale L Barnard; Craig L Hill; T Gage; J E Matheson; JH Huffman; Robert W Sidwell; M I Otto; Ray F Schinazi
Potent inhibition of respiratory syncytial virus by polyoxometalates of several structural classes.
Antiviral research 1997;34(1):27-37.
1997: RA Smith; K M Remington; R M Lloyd; Ray F Schinazi; Thomas W North
A novel Met-to-Thr mutation in the YMDD motif of reverse transcriptase from feline immunodeficiency virus confers resistance to oxathiolane nucleosides.
Journal of virology 1997;71(3):2357-62.
1997: Lieven Stuyver; A Wyseur; A Rombout; joost louwagie; T Scarcez; Chris Verhofstede; D Rimland; Ray F Schinazi; Rudi Rossau
Line probe assay for rapid detection of drug-selected mutations in the human immunodeficiency virus type 1 reverse transcriptase gene.
Antimicrobial agents and chemotherapy 1997;41(2):284-91.
1997: LT Martin; Abdesslem Faraj; Ray F Schinazi; Gilles Gosselin; C Mathe; Jean-Louis Imbach; Jean-Pierre Sommadossi
Effect of stereoisomerism on the cellular pharmacology of beta-enantiomers of cytidine analogs in Hep-G2 cells.
Biochemical pharmacology 1997;53(1):75-87.
1996: Lakshmi P Kotra; K K Manouilov; Erika Cretton-Scott; Jean-Pierre Sommadossi; F Douglas Boudinot; Ray F Schinazi; Chung (David) K. Chu
Synthesis, biotransformation, and pharmacokinetic studies of 9-(beta-D-arabinofuranosyl)-6-azidopurine: a prodrug for ara-A designed to utilize the azide reduction pathway.
Journal of medicinal chemistry 1996;39(26):5202-7.
1996: L Cui; Ray F Schinazi; Gilles Gosselin; Jean-Louis Imbach; Chung (David) K. Chu; RF Rando; G R Revankar; Jean-Pierre Sommadossi
Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity.
Biochemical pharmacology 1996;52(10):1577-84.
1996: T Koudriakova; K K Manouilov; K Shanmuganathan; Lakshmi P Kotra; F Douglas Boudinot; Erika Cretton-Scott; Jean-Pierre Sommadossi; Ray F Schinazi; Chung (David) K. Chu
In vitro and in vivo evaluation of 6-azido-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosylpurine and N6-methyl-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosyladenine as prodrugs of the anti-HIV nucleosides 2'-F-ara-ddA and 2'-F-ara-ddI.
Journal of medicinal chemistry 1996;39(23):4676-81.
1996: H Chen; F Douglas Boudinot; Chung (David) K. Chu; H M Mcclure; Ray F Schinazi
Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1996;40(10):2332-6.
1996: P Rajagopalan; F Wudl; Ray F Schinazi; F Douglas Boudinot
Pharmacokinetics of a water-soluble fullerene in rats.
Antimicrobial agents and chemotherapy 1996;40(10):2262-5.
1996: X You; Michael J Arrowood; M Lejkowski; L Xie; Ray F Schinazi; Jan R Mead
In vitro evaluation of anticryptosporidial agents using MDCK cell culture and chemiluminescence immunoassay.
The Journal of eukaryotic microbiology 1996;43(5):87S.
1996: Jan R Mead; María-Teresa Bonafonte; Michael J Arrowood; Ray F Schinazi
In vitro expression of mRNA coding for a Cryptosporidium parvum oocyst wall protein.
The Journal of eukaryotic microbiology 1996;43(5):84S-85S.
1996: María-Teresa Bonafonte; R M Lloyd; K D Garmon; X You; Michael J Arrowood; Ray F Schinazi; Jan R Mead
Cloning and expression of sporozoite and oocyst Cryptosporidium parvum recombinant proteins.
The Journal of eukaryotic microbiology 1996;43(5):83S.
1996: Mahmoud el Kouni; Fardos N M Naguib; R P Panzica; B A Otter; S H Chu; Gilles Gosselin; Chung (David) K. Chu; Ray F Schinazi; Y F Shealy; N Goudgaon; A A Ozerov; T Ueda; M H Iltzsch
Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii.
Biochemical pharmacology 1996;51(12):1687-700.
1996: Z J Lesnikowski; G Fulcrand; R M Lloyd; A Juodawlkis; Ray F Schinazi
Carboranyl oligonucleotides. 3. Biochemical properties of oligonucleotides containing 5-(o-carboranyl-1-yl)-2'-deoxyuridine.
Biochemistry 1996;35(18):5741-6.
1996: Julie M Cherrington; Michael D Fuller; Andrew S Mulato; S J Allen; S C Kunder; M A Ussery; Z Lesnikowski; Ray F Schinazi; J P Sommadossi; MS Chen
Comparative kinetic analyses of interaction of inhibitors with Rauscher murine leukemia virus and human immunodeficiency virus reverse transcriptases.
Antimicrobial agents and chemotherapy 1996;40(5):1270-3.
1996: A Mazumder; Nouri Neamati; J P Sommadossi; G Gosselin; Ray F Schinazi; J L Imbach; Yves Pommier
Effects of nucleotide analogues on human immunodeficiency virus type 1 integrase.
Molecular pharmacology 1996;49(4):621-8.
1996: X You; Michael J Arrowood; M Lejkowski; L Xie; Ray F Schinazi; Jan R Mead
A chemiluminescence immunoassay for evaluation of Cryptosporidium parvum growth in vitro.
FEMS microbiology letters 1996;136(3):251-6.
1996: P Rajagopalan; F Douglas Boudinot; Chung (David) K. Chu; Bud C Tennant; Betty H Baldwin; Ray F Schinazi
Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks.
Antimicrobial agents and chemotherapy 1996;40(3):642-5.
1996: Abdesslem Faraj; Ray F Schinazi; M Y Xie; Gilles Gosselin; C Perigaud; Jean-Louis Imbach; Jean-Pierre Sommadossi
Selective protection of toxicity of 2',3'-dideoxypyrimidine nucleoside analogs by beta-D-uridine in human granulocyte-macrophage progenitor cells.
Antiviral research 1996;29(2-3):261-7.
1995: Ray F Schinazi; X Yao
Hydrocephalus induction in mice infected with herpes simplex virus type 2 after antiviral treatment.
Antiviral research 1995;28(4):291-302.
1995: P Rajagopalan; Z Gao; Chung (David) K. Chu; Ray F Schinazi; H M McClure; F Douglas Boudinot
High-performance liquid chromatographic determination of (-)-beta-D-2,6-diaminopurine dioxolane and its metabolite, dioxolane guanosine, using ultraviolet and on-line radiochemical detection.
Journal of chromatography. B, Biomedical applications 1995;672(1):119-24.
1995: H Xie; M Voronkov; Dennis C Liotta; B A Korba; Ray F Schinazi; Douglas D Richman; Karl Y Hostetler
Phosphatidyl-2',3'-dideoxy-3'-thiacytidine: synthesis and antiviral activity in hepatitis B-and HIV-1-infected cells.
Antiviral research 1995;28(2):113-20.
1995: J Wengel; Ray F Schinazi; M H Caruthers
Stereoselective synthesis, chemistry and antiviral evaluation of 1-(2,3-dideoxy-3-C-hydroxymethyl-beta-D-threo-pentofuranosyl)thymine derivatives.
Bioorganic & medicinal chemistry 1995;3(9):1223-9.
1995: J W Mellors; H Z Bazmi; Ray F Schinazi; B M Roy; Y Hsiou; Eddy Arnold; J Weir; D L Mayers
Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates.
Antimicrobial agents and chemotherapy 1995;39(5):1087-92.
1995: L Ni; Ray F Schinazi; F Douglas Boudinot
Pharmacokinetics and toxicity of the human immunodeficiency virus inhibitor 1-ethoxymethyl-6-phenylselenenyl-5-ethyluracil in rodents.
Antiviral research 1995;27(1-2):39-47.
1995: Jan R Mead; X You; J E Pharr; Y Belenkaya; Michael J Arrowood; M T Fallon; Ray F Schinazi
Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis.
Antimicrobial agents and chemotherapy 1995;39(4):854-8.
1995: L Cui; S Yoon; Ray F Schinazi; Jean-Pierre Sommadossi
Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.
The Journal of clinical investigation 1995;95(2):555-63.
1994: V R Jarugula; Ray F Schinazi; G Fulcrand; Y el Kattan; Dennis C Liotta; F Douglas Boudinot
Pharmacokinetics of 5-carboranyl-2'-deoxyuridine in rats.
Journal of pharmaceutical sciences 1994;83(12):1697-9.
1994: M H Nguyen; Ray F Schinazi; C Shi; N M Goudgaon; P M McKenna; J W Mellors
Resistance of human immunodeficiency virus type 1 to acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidines.
Antimicrobial agents and chemotherapy 1994;38(10):2409-14.
1994: Abdesslem Faraj; L A Agrofoglio; J K Wakefield; Sylvia A McPherson; Casey D Morrow; Gilles Gosselin; C Mathe; Jean-Louis Imbach; Ray F Schinazi; Jean-Pierre Sommadossi
Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs.
Antimicrobial agents and chemotherapy 1994;38(10):2300-5.
1994: M S Belen'kii; Ray F Schinazi
Multiple drug effect analysis with confidence interval.
Antiviral research 1994;25(1):1-11.
1994: Ray F Schinazi; Gilles Gosselin; Abdesslem Faraj; B E Korba; Dennis C Liotta; Chung (David) K. Chu; Christophe Mathé; Jean-Louis Imbach; Jean-Pierre Sommadossi
Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro.
Antimicrobial agents and chemotherapy 1994;38(9):2172-4.
1994: Jan R Mead; R M Lloyd; X You; Carol Tucker-Burden; Michael J Arrowood; Ray F Schinazi
Isolation and partial characterization of Cryptosporidium sporozoite and oocyst wall recombinant proteins.
The Journal of eukaryotic microbiology 1994;41(5):51S.
1994: G Fulcrand-el Kattan; N M Goudgaon; N Ilksoy; J T Huang; K A Watanabe; Jean-Pierre Sommadossi; Ray F Schinazi
Synthesis and biological properties of 5-o-carboranyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil.
Journal of medicinal chemistry 1994;37(16):2583-8.
1994: Gilles Gosselin; Ray F Schinazi; Jean-Pierre Sommadossi; Christophe Mathé; M C Bergogne; A M Aubertin; A Kirn; Jean-Louis Imbach
Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro.
Antimicrobial agents and chemotherapy 1994;38(6):1292-7.
1994: Jan R Mead; N Ilksoy; X You; Y Belenkaya; Michael J Arrowood; M T Fallon; Ray F Schinazi
Infection dynamics and clinical features of cryptosporidiosis in SCID mice.
Infection and immunity 1994;62(5):1691-5.
1994: Ray F Schinazi; N M Goudgaon; G Fulcrand; Y el Kattan; Z Lesnikowski; G Ullas; J Moravek; Dennis C Liotta
Cellular pharmacology and biological activity of 5-carboranyl-2'-deoxyuridine.
International journal of radiation oncology, biology, physics 1994;28(5):1113-20.
1994: K Shanmuganathan; T Koudriakova; S Nampalli; J Du; J M Gallo; Ray F Schinazi; Chung (David) K. Chu
Enhanced brain delivery of an anti-HIV nucleoside 2'-F-ara-ddI by xanthine oxidase mediated biotransformation.
Journal of medicinal chemistry 1994;37(6):821-7.
1994: G S Kim; D A Judd; Craig L Hill; Ray F Schinazi
Synthesis, characterization, and biological activity of a new potent class of anti-HIV agents, the peroxoniobium-substituted heteropolytungstates.
Journal of medicinal chemistry 1994;37(6):816-20.
1994: Ray F Schinazi; R M Lloyd; C S Ramanathan; E W Taylor
Antiviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase occur in specific RNA structural regions.
Antimicrobial agents and chemotherapy 1994;38(2):268-74.
1994: S Z Abghari; R Doyle Stulting; Z Zhu; Ray F Schinazi; H E Kaufman
Effect of genetically determined host factors on the efficacy of vidarabine, acyclovir and 5-trifluorothymidine in herpes simplex virus type 1 infection.
Ophthalmic research 1994;26(2):95-104.
1994: C V Abobo; L Ni; Ray F Schinazi; Dennis C Liotta; F Douglas Boudinot
Pharmacokinetics of 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats.
Journal of pharmaceutical sciences 1994;83(1):96-9.
1994: Gilles Gosselin; Christophe Mathé; M C Bergogne; A M Aubertin; A Kirn; Ray F Schinazi; Jean-Pierre Sommadossi; Jean-Louis Imbach
Enantiomeric 2',3'-dideoxycytidine derivatives are potent human immunodeficiency virus inhibitors in cell cultures.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1994;317(1):85-9.
1993: N M Goudgaon; Fardos N M Naguib; Mahmoud el Kouni; Ray F Schinazi
Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase.
Journal of medicinal chemistry 1993;36(26):4250-4.
1993: Dominique Mathez; Ray F Schinazi; Dennis C Liotta; Jacques Leibowitch
Infectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro.
Antimicrobial agents and chemotherapy 1993;37(10):2206-11.
1993: Lak Shin Jeong; Ray F Schinazi; J Warren Beach; H O Kim; K Shanmuganathan; S Nampalli; Moon Woo Chun; W K Chung; B G Choi; Chung (David) K. Chu
Structure-activity relationships of beta-D-(2S,5R)- and alpha-D-(2S,5S)-1,3-oxathiolanyl nucleosides as potential anti-HIV agents.
Journal of medicinal chemistry 1993;36(18):2627-38.
1993: F Douglas Boudinot; Ray F Schinazi; K J Doshi; H M McClure; Chung (David) K. Chu
Pharmacokinetics and metabolism of 3'-azido-2',3'-dideoxy-5-methylcytidine in rhesus monkeys.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(5):855-60.
1993: Xinli Lin; Azar M Dashti; Ray F Schinazi; Jordan Tang
Intracellular diversion of glycoprotein GP160 of human immunodeficiency virus to lysosomes as a strategy of AIDS gene therapy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(11):1070-80.
1993: Ray F Schinazi; R Sijbesma; G Srdanov; Craig L Hill; F Wudl
Synthesis and virucidal activity of a water-soluble, configurationally stable, derivatized C60 fullerene.
Antimicrobial agents and chemotherapy 1993;37(8):1707-10.
1993: T S Lin; Ray F Schinazi; J Zhu; E Birks; Rocco Carbone; Y Si; K Wu; L Huang; W H Prusoff
Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol.
Biochemical pharmacology 1993;46(2):251-5.
1993: Donna S Shewach; Dennis C Liotta; Ray F Schinazi
Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2'-deoxycytidine kinase.
Biochemical pharmacology 1993;45(7):1540-3.
1993: Ray F Schinazi; R M Lloyd; M H Nguyen; D L Cannon; A McMillan; N Ilksoy; Chung (David) K. Chu; Dennis C Liotta; H Z Bazmi; J W Mellors
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides.
Antimicrobial agents and chemotherapy 1993;37(4):875-81.
1993: H O Kim; Ray F Schinazi; K Shanmuganathan; Lak Shin Jeong; J Warren Beach; S Nampalli; D L Cannon; Chung (David) K. Chu
L-beta-(2S,4S)- and L-alpha-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships.
Journal of medicinal chemistry 1993;36(5):519-28.
1993: Ray F Schinazi; V E Del Bene
Non-HIV-1 CD4+ lymphocyte depletion in a patient with an acquired immunodeficiency syndrome of unknown etiology.
AIDS (London, England) 1993;7(2):284-5.
1993: Lak Shin Jeong; Ray F Schinazi; J Warren Beach; H O Kim; S Nampalli; K Shanmuganathan; A J Alves; A McMillan; Chung (David) K. Chu; R Mathis
Asymmetric synthesis and biological evaluation of beta-L-(2R,5S)- and alpha-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents.
Journal of medicinal chemistry 1993;36(2):181-95.
1993: H O Kim; Ray F Schinazi; S Nampalli; K Shanmuganathan; D L Cannon; A J Alves; Lak Shin Jeong; J Warren Beach; Chung (David) K. Chu
1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes.
Journal of medicinal chemistry 1993;36(1):30-7.
1992: Jean-Pierre Sommadossi; Ray F Schinazi; Chung (David) K. Chu; M Y Xie
Comparison of cytotoxicity of the (-)- and (+)-enantiomer of 2',3'-dideoxy-3'-thiacytidine in normal human bone marrow progenitor cells.
Biochemical pharmacology 1992;44(10):1921-5.
1992: Ray F Schinazi; F Douglas Boudinot; S S Ibrahim; C Manning; H M McClure; Dennis C Liotta
Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1992;36(11):2432-8.
1992: Ray F Schinazi; A McMillan; D Cannon; R Mathis; R M Lloyd; A Peck; J P Sommadossi; Marty St Clair; J Wilson; P A Furman
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine.
Antimicrobial agents and chemotherapy 1992;36(11):2423-31.
1992: E M Cretton; M Y Xie; N M Goudgaon; Ray F Schinazi; Chung (David) K. Chu; Jean-Pierre Sommadossi
Catabolic disposition of 3'-azido-2',3'-dideoxyuridine in hepatocytes with evidence of azido reduction being a general catabolic pathway of 3'-azido-2',3'-dideoxynucleosides.
Biochemical pharmacology 1992;44(5):973-80.
1992: I B Taraporewala; James W Cessac; T C Chanh; A V Delgado; Ray F Schinazi
HIV-1 neutralization and tumor cell proliferation inhibition in vitro by simplified analogues of pyrido[4,3,2-mn]thiazolo[5,4-b]acridine marine alkaloids.
Journal of medicinal chemistry 1992;35(15):2744-52.
1992: Ray F Schinazi; A Peck; J P Sommadossi
Substrate specificity of Escherichia coli thymidine phosphorylase for pyrimidine nucleosides with anti-human immunodeficiency virus activity.
Biochemical pharmacology 1992;44(2):199-204.
1992: C N Chang; S L Doong; J H Zhou; J Warren Beach; Lak Shin Jeong; Chung (David) K. Chu; C H Tsai; Yung-Chi Cheng; Dennis C Liotta; Ray F Schinazi
Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.
The Journal of biological chemistry 1992;267(20):13938-42.
1992: Ray F Schinazi; Jan R Mead; P M Feorino
Insights into HIV chemotherapy.
AIDS research and human retroviruses 1992;8(6):963-90.
1992: H O Kim; S K Ahn; A J Alves; J Warren Beach; Lak Shin Jeong; B G Choi; P Van Roey; Ray F Schinazi; Chung (David) K. Chu
Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.
Journal of medicinal chemistry 1992;35(11):1987-95.
1992: M S Weeks; Craig L Hill; Ray F Schinazi
Synthesis, characterization, and anti-human immunodeficiency virus activity of water-soluble salts of polyoxotungstate anions with covalently attached organic groups.
Journal of medicinal chemistry 1992;35(7):1216-21.
1992: Ray F Schinazi; Chung (David) K. Chu; A Peck; A McMillan; R Mathis; D Cannon; Lak Shin Jeong; J Warren Beach; W B Choi; S Yeola
Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.
Antimicrobial agents and chemotherapy 1992;36(3):672-6.
1992: T J Bardos; Ray F Schinazi; K H Ling; A R Heider
Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1992;36(1):108-14.
1991: N M Goudgaon; Ray F Schinazi
Activity of acyclic 6-(phenylselenenyl)pyrimidine nucleosides against human immunodeficiency viruses in primary lymphocytes.
Journal of medicinal chemistry 1991;34(11):3305-9.
1991: S L Doong; C H Tsai; Ray F Schinazi; Dennis C Liotta; Yung-Chi Cheng
Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8495-9.
1991: Lucjan Strekowski; J L Mokrosz; V A Honkan; A Czarny; M T Cegla; R L Wydra; S E Patterson; Ray F Schinazi
Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-HIV-1 agents.
Journal of medicinal chemistry 1991;34(5):1739-46.
1991: E M Cretton; Ray F Schinazi; H M McClure; D C Anderson; Jean-Pierre Sommadossi
Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys.
Antimicrobial agents and chemotherapy 1991;35(5):801-7.
1991: F Douglas Boudinot; S G Smith; E D Funderburg; Ray F Schinazi
Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rats.
Antimicrobial agents and chemotherapy 1991;35(4):747-9.
1991: E M Cretton; M Y Xie; R J Bevan; N M Goudgaon; Ray F Schinazi; Jean-Pierre Sommadossi
Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells.
Molecular pharmacology 1991;39(2):258-66.
1990: Z Zhu; Ray F Schinazi; Chung (David) K. Chu; G J Williams; C B Colby; Jean-Pierre Sommadossi
Cellular metabolism of 3'-azido-2',3'-dideoxyuridine with formation of 5'-O-diphosphohexose derivatives by previously unrecognized metabolic pathways for 2'-deoxyuridine analogs.
Molecular pharmacology 1990;38(6):929-38.
1990: Craig L Hill; M S Weeks; Ray F Schinazi
Anti-HIV-1 activity, toxicity, and stability studies of representative structural families of polyoxometalates.
Journal of medicinal chemistry 1990;33(10):2767-72.
1990: K Hirota; H Hosono; Y Kitade; Y Maki; Chung (David) K. Chu; Ray F Schinazi; H Nakane; K Ono
Synthesis and anti-human immunodeficiency virus (HIV-1) activity of 3'-deoxy-3'-(triazol-1-yl)thymidines and 2',3'-dideoxy-3'-(triazol-1-yl)uridines and inhibition of reverse transcriptase by their 5'-triphosphates.
Chemical & pharmaceutical bulletin 1990;38(9):2597-601.
1990: Chung (David) K. Chu; V S Bhadti; K J Doshi; J T Etse; J M Gallo; F Douglas Boudinot; Ray F Schinazi
Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine.
Journal of medicinal chemistry 1990;33(8):2188-92.
1990: Ray F Schinazi; J P Sommadossi; V Saalmann; D L Cannon; M Y Xie; G C Hart; G A Smith; E F Hahn
Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1990;34(6):1061-7.
1990: Chung (David) K. Chu; G V Ullas; Lak Shin Jeong; S K Ahn; B Doboszewski; Z X Lin; J Warren Beach; Ray F Schinazi
Synthesis and structure-activity relationships of 6-substituted 2',3'-dideoxypurine nucleosides as potential anti-human immunodeficiency virus agents.
Journal of medicinal chemistry 1990;33(6):1553-61.
1990: Ray F Schinazi; F Douglas Boudinot; K J Doshi; H M McClure
Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1990;34(6):1214-9.
1990: Ray F Schinazi; Chung (David) K. Chu; J R Babu; B J Oswald; V Saalmann; D L Cannon; B F Eriksson; M Nasr
Anthraquinones as a new class of antiviral agents against human immunodeficiency virus.
Antiviral research 1990;13(5):265-72.
1990: B A Patel; F Douglas Boudinot; Ray F Schinazi; J M Gallo; Chung (David) K. Chu
Comparative pharmacokinetics and interspecies scaling of 3'-azido-3'-deoxythymidine (AZT) in several mammalian species.
Journal of pharmacobio-dynamics 1990;13(3):206-11.
1990: F Douglas Boudinot; Ray F Schinazi; J M Gallo; H M McClure; D C Anderson; K J Doshi; P C Kambhampathi; Chung (David) K. Chu
3'-Azido-2',3'-dideoxyuridine (AzddU): comparative pharmacokinetics with 3'-azido-3'-deoxythymidine (AZT) in monkeys.
AIDS research and human retroviruses 1990;6(2):219-28.
1990: R McCaffrey; R Duff; K Bulger; Z Spigelman; K Flora; Ray F Schinazi; Chung (David) K. Chu
Terminal transferase as a therapeutic target in leukemia cells.
Progress in clinical and biological research 1990;352():409-16.
1990: H M McClure; D C Anderson; Aftab A Ansari; P N Fultz; S A Klumpp; Ray F Schinazi
Nonhuman primate models for evaluation of AIDS therapy.
Annals of the New York Academy of Sciences 1990;616():287-98.
1990: John N Weinstein; B Bunow; O S Weislow; Ray F Schinazi; S M Wahl; L M Wahl; J Szebeni
Synergistic drug combinations in AIDS therapy. Dipyridamole/3'-azido-3'-deoxythymidine in particular and principles of analysis in general.
Annals of the New York Academy of Sciences 1990;616():367-84.
1990: Ray F Schinazi; Chung (David) K. Chu; B F Eriksson; J P Sommadossi; K J Doshi; F Douglas Boudinot; B Oswald; H M McClure
Antiretroviral activity, biochemistry, and pharmacokinetics of 3'-azido-2',3'-dideoxy-5-methylcytidine.
Annals of the New York Academy of Sciences 1990;616():385-97.
1990: P Van Roey; E W Taylor; Chung (David) K. Chu; Ray F Schinazi
Correlation of molecular conformation and activity of reverse transcriptase inhibitors.
Annals of the New York Academy of Sciences 1990;616():29-40.
1989: T S Lin; Ray F Schinazi; B P Griffith; E M August; B F Eriksson; D K Zheng; L A Huang; W H Prusoff
Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol.
Antimicrobial agents and chemotherapy 1989;33(12):2149-51.
1989: K J Doshi; J M Gallo; F Douglas Boudinot; Ray F Schinazi; Chung (David) K. Chu
Comparative pharmacokinetics of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZddU) in mice.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(6):590-4.
1989: B F Eriksson; Chung (David) K. Chu; Ray F Schinazi
Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate.
Antimicrobial agents and chemotherapy 1989;33(10):1729-34.
1989: P Van Roey; J M Salerno; Chung (David) K. Chu; Ray F Schinazi
Correlation between preferred sugar ring conformation and activity of nucleoside analogues against human immunodeficiency virus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):3929-33.
1989: B F Eriksson; Ray F Schinazi
Combinations of 3'-azido-3'-deoxythymidine (zidovudine) and phosphonoformate (foscarnet) against human immunodeficiency virus type 1 and cytomegalovirus replication in vitro.
Antimicrobial agents and chemotherapy 1989;33(5):663-9.
1989: Chung (David) K. Chu; Ray F Schinazi; M K Ahn; G V Ullas; Z P Gu
Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells.
Journal of medicinal chemistry 1989;32(3):612-7.
1989: P Scheiner; A Geer; A M Bucknor; J L Imbach; Ray F Schinazi
Acyclic analogues of 3'-azido-3'-deoxythymidine as potential antiviral agents. Nucleoside synthesis by Michael addition.
Journal of medicinal chemistry 1989;32(1):73-6.
1989: Ray F Schinazi; B F Eriksson; S H Hughes
Comparison of inhibitory activities of various antiretroviral agents against particle-derived and recombinant human immunodeficiency virus type 1 reverse transcriptases.
Antimicrobial agents and chemotherapy 1989;33(1):115-7.
1988: Ray F Schinazi; D L Cannon; B H Arnold; D Martino-Saltzman
Combinations of isoprinosine and 3'-azido-3'-deoxythymidine in lymphocytes infected with human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1988;32(12):1784-7.
1988: Chung (David) K. Chu; Ray F Schinazi; B H Arnold; D L Cannon; B Doboszewski; V B Bhadti; Z P Gu
Comparative activity of 2',3'-saturated and unsaturated pyrimidine and purine nucleosides against human immunodeficiency virus type 1 in peripheral blood mononuclear cells.
Biochemical pharmacology 1988;37(19):3543-8.
1988: Jean-Pierre Sommadossi; R Carlisle; Ray F Schinazi; Z Zhou
Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity.
Antimicrobial agents and chemotherapy 1988;32(7):997-1001.
1988: T S Lin; J Y Guo; Ray F Schinazi; Chung (David) K. Chu; J N Xiang; W H Prusoff
Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV).
Journal of medicinal chemistry 1988;31(2):336-40.
1987: T S Lin; Ray F Schinazi; W H Prusoff
Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus.
Biochemical pharmacology 1987;36(17):2713-8.
1987: D C Mundy; Ray F Schinazi; A R Gerber; A J Nahmias; H W Randall
Human immunodeficiency virus isolated from amniotic fluid.
Lancet 1987;2(8556):459-60.
1987: Ray F Schinazi
Drug combinations for treatment of mice infected with acyclovir-resistant herpes simplex virus.
Antimicrobial agents and chemotherapy 1987;31(3):477-9.
1987: T S Lin; Ray F Schinazi; M S Chen; E Kinney-Thomas; W H Prusoff
Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro.
Biochemical pharmacology 1987;36(3):311-6.
1987: K Harada; J Matulic-Adamic; R W Price; Ray F Schinazi; KA Watanabe; J J Fox
Nucleosides. 139. Synthesis and anticytomegalovirus and antiherpes simplex virus activity of 5'-modified analogues of 2'-fluoroarabinosylpyrimidine nucleosides.
Journal of medicinal chemistry 1987;30(1):226-9.
1987: J T Huang; Ray F Schinazi; H Gadler; R W Price; T L Su; KA Watanabe
5-substituted 2'-fluoro-arabinonucleosides as potential antiviral agents.
Nucleic acids symposium series 1987;(18):261-4.
1986: Ray F Schinazi; V del Bene; R T Scott; J B Dudley-Thorpe
Characterization of acyclovir-resistant and -sensitive herpes simplex viruses isolated from a patient with an acquired immune deficiency.
The Journal of antimicrobial chemotherapy 1986;18 Suppl B():127-34.
1986: Ray F Schinazi; T C Chou; R T Scott; X J Yao; A J Nahmias
Delayed treatment with combinations of antiviral drugs in mice infected with herpes simplex virus and application of the median effect method of analysis.
Antimicrobial agents and chemotherapy 1986;30(3):491-8.
1986: Ray F Schinazi; J Arbiser; J J Lee; T I Kalman; W H Prusoff
Synthesis and biological activity of 5-phenylselenenyl-substituted pyrimidine nucleosides.
Journal of medicinal chemistry 1986;29(7):1293-5.
1986: Ray F Schinazi; J J Fox; K A Watanabe; A J Nahmias
Activities of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2.
Antimicrobial agents and chemotherapy 1986;29(1):77-84.
1986: T L Su; K A Watanabe; Ray F Schinazi; J J Fox
Nucleosides. 136. Synthesis and antiviral effects of several 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-alkyluracils. Some structure-activity relationships.
Journal of medicinal chemistry 1986;29(1):151-4.
1985: Ray F Schinazi; R T Scott; J Peters; V Rice; A J Nahmias
Antiviral activity of 5-ethyl-2'-deoxyuridine against herpes simplex viruses in cell culture, mice, and guinea pigs.
Antimicrobial agents and chemotherapy 1985;28(4):552-60.
1985: M E Perlman; K A Watanabe; Ray F Schinazi; J J Fox
Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
Journal of medicinal chemistry 1985;28(6):741-8.
1984: Karel A Schat; Ray F Schinazi; BW Calnek
Cell-specific antiviral activity of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) against Marek's disease herpesvirus and turkey herpesvirus.
Antiviral research 1984;4(5):259-70.
1983: Ray F Schinazi; J Peters; M K Sokol; A J Nahmias
Therapeutic activities of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine and -thymine alone and in combination with acyclovir and vidarabine in mice infected intracerebrally with herpes simplex virus.
Antimicrobial agents and chemotherapy 1983;24(1):95-103.
1983: Ray F Schinazi; W H Prusoff
Antiviral agents.
Pediatric clinics of North America 1983;30(1):77-92.
1982: D H Harrison; Ray F Schinazi; B H Rubin
Crystal structure and anti herpes simplex virus activity of 2,2'-anhydro-1-beta-D-arabinofuranosylthymine.
Journal of medicinal chemistry 1982;25(12):1507-10.
1982: Yung-Chi Cheng; Ray F Schinazi; Ginger E Dutschman; R S Tan; S P Grill
Virus-induced thymidine kinases as markers for typing herpes simplex viruses and for drug sensitivity assays.
Journal of virological methods 1982;5(3-4):209-17.
1982: Ray F Schinazi; J Peters; C C Williams; D Chance; A J Nahmias
Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice.
Antimicrobial agents and chemotherapy 1982;22(3):499-507.
1982: Ray F Schinazi; A J Nahmias
Different in vitro effects of dual combinations of anti-herpes simplex virus compounds.
The American journal of medicine 1982;73(1A):40-8.
1981: Ray F Schinazi; W H Prusoff
Antiviral drugs: modes of action and strategies for therapy.
Hospital practice (Office ed.) 1981;16(6):113-24.
1981: T L Stanwick; Ray F Schinazi; D E Campbell; A J Nahmias
Combined antiviral effect of interferon and acyclovir on herpes simplex virus types 1 and 2.
Antimicrobial agents and chemotherapy 1981;19(4):672-4.
1980: G T Shiau; Ray F Schinazi; M S Chen; W H Prusoff
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
Journal of medicinal chemistry 1980;23(2):127-33.
1979: Ray F Schinazi; M S Chen; W H Prusoff
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
Journal of medicinal chemistry 1979;22(10):1273-7.
1979: W H Prusoff; M S Chen; P H Fischer; T S Lin; G T Shiau; Ray F Schinazi; J Walker
Antiviral iodinated pyrimidine deoxyribonucleosides: 5-iodo-2'-deoxyuridine; 5-iodo-2'-deoxycytidine; 5-iodo-5'-amino-2',5'-dideoxyuridine.
Pharmacology & therapeutics 1979;7(1):1-34.
1979: W H Prusoff; M S Chen; P H Fischer; T S Lin; G T Shiau; Ray F Schinazi
Role of nucleosides in virus and cancer chemotherapy.
Advances in ophthalmology = Fortschritte der Augenheilkunde = Progrès en ophtalmologie 1979;38():3-16.
1978: Ray F Schinazi; M S Chen; W H Prusoff
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
Journal of medicinal chemistry 1978;21(11):1141-6.