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Ray Schinazi

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
101
Chu, Chung (David) K.
28
Stuyver, Lieven
27
Sommadossi, Jean-Pierre
24
Otto, Michael
22
Hurwitz, Selwyn
22
Boudinot, Douglas
19
Liotta, Dennis
17
Tharnish, Phillip
16
Gosselin, Gilles
16
Imbach, Jean-Louis
15
McBrayer, Tamara
14
Shi, Junxing
14
Watanabe, Kyoichi
12
el Kouni, Mahmoud
12
Anderson, Karen

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Publications

TOP 3
Fromentin Emilie; Asif Ghazia; Obikhod Aleksandr; Hurwitz Selwyn J; Schinazi Raymond F
Simultaneous quantification of 9-(beta-D-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography-tandem mass spectrometric assay.
Amblard Franck; Fromentin Emilie; Detorio Mervi; Obikhod Alexander; Rapp Kimberly L; McBrayer Tamara R; Whitaker Tony; Coats Steven J; Schinazi Raymond F
Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.
Amblard Franck; Cho Jong Hyun; Schinazi Raymond F
Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry.

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All Publications

2009: Fromentin Emilie; Asif Ghazia; Obikhod Aleksandr; Hurwitz Selwyn J; Schinazi Raymond F
Simultaneous quantification of 9-(beta-D-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography-tandem mass spectrometric assay.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(29):3482-8.
2009: Amblard Franck; Fromentin Emilie; Detorio Mervi; Obikhod Alexander; Rapp Kimberly L; McBrayer Tamara R; Whitaker Tony; Coats Steven J; Schinazi Raymond F
Synthesis, antiviral activity, and stability of nucleoside analogs containing tricyclic bases.
European journal of medicinal chemistry 2009;44(10):3845-51.
2009: Amblard Franck; Cho Jong Hyun; Schinazi Raymond F
Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry.
Chemical reviews 2009;109(9):4207-20.
2009: Tchesnokov Egor P; Obikhod Aleksandr; Schinazi Raymond F; Götte Matthias
Engineering of a chimeric RB69 DNA polymerase sensitive to drugs targeting the cytomegalovirus enzyme.
The Journal of biological chemistry 2009;284(39):26439-46.
2009: Sluis-Cremer Nicolas; Koontz Dianna; Bassit Leda; Hernandez-Santiago Brenda I; Detorio Mervi; Rapp Kim L; Amblard Franck; Bondada Lavanya; Grier Jason; Coats Steven J; Schinazi Raymond F; Mellors John W
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Antimicrobial agents and chemotherapy 2009;53(9):3715-9.
2009: Sharma Prem L; Nettles James H; Feldman Anya; Rapp Kimberly; Schinazi Raymond F
Comparative analysis of in vitro processivity of HIV-1 reverse transcriptases containing mutations 65R, 74V, 184V and 65R+74V.
Antiviral research 2009;83(3):317-23.
2009: Tchesnokov Egor P; Obikhod Aleksandr; Massud Ivana; Lisco Andrea; Vanpouille Christophe; Brichacek Beda; Balzarini Jan; McGuigan Christopher; Derudas Marco; Margolis Leonid; Schinazi Raymond F; Götte Matthias
Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase.
The Journal of biological chemistry 2009;284(32):21496-504.
2009: Díaz-Rodríguez Alba; Sanghvi Yogesh S; Fernández Susana; Schinazi Raymond F; Theodorakis Emmanuel A; Ferrero Miguel; Gotor Vicente
Synthesis and anti-HIV activity of conformationally restricted bicyclic hexahydroisobenzofuran nucleoside analogs.
Organic & biomolecular chemistry 2009;7(7):1415-23.
2009: Kline Erik R; Bassit Leda; Hernandez-Santiago Brenda I; Detorio Mervi A; Liang Bill; Kleinhenz Dean J; Walp Erik R; Dikalov Sergey; Jones Dean P; Schinazi Raymond F; Sutliff Roy L
Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction.
Cardiovascular toxicology 2009;9(1):1-12.
2009: Liang Yuzeng; Sharon Ashoke; Grier Jason P; Rapp Kimberly L; Schinazi Raymond F; Chu Chung K
5'-O-Aliphatic and amino acid ester prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine (DOT): synthesis, anti-HIV activity, cytotoxicity and stability studies.
Bioorganic & medicinal chemistry 2009;17(3):1404-9.
2009: Kim Hyo-Joong; Sharon Ashoke; Bal Chandralata; Wang Jianing; Allu Madhan; Huang Zhuhui; Murray Michael G; Bassit Leda; Schinazi Raymond F; Korba Brent; Chu Chung K
Synthesis and anti-hepatitis B virus and anti-hepatitis C virus activities of 7-deazaneplanocin A analogues in vitro.
Journal of medicinal chemistry 2009;52(1):206-13.
2009: Schinazi Raymond F; Coats Steven J; Bassit Leda C; Lennerstrand Johan; Nettles James H; Hurwitz Selwyn J
Approaches for the development of antiviral compounds: the case of hepatitis C virus.
Handbook of experimental pharmacology 2009;(189):25-51.
2008: Tchesnokov Egor P; Obikhod Aleksandr; Schinazi Raymond F; Götte Matthias
Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase.
The Journal of biological chemistry 2008;283(49):34218-28.
2008: Hurwitz Selwyn J; Asif Ghazia; Kivel Nancy M; Schinazi Raymond F
Development of an optimized dose for coformulation of zidovudine with drugs that select for the K65R mutation using a population pharmacokinetic and enzyme kinetic simulation model.
Antimicrobial agents and chemotherapy 2008;52(12):4241-50.
2008: Kalichman Seth C; Amaral Christina M; Cherry Chauncey; Flanagan Jody; Pope Howard; Eaton Lisa; Kalichman Moira O; Cain Demetria; Detorio Mervi; Caliendo Angela; Schinazi Raymond F
Monitoring medication adherence by unannounced pill counts conducted by telephone: reliability and criterion-related validity.
HIV clinical trials 2008;9(5):298-308.
2008: Lisco Andrea; Vanpouille Christophe; Tchesnokov Egor P; Grivel Jean-Charles; Biancotto Angélique; Brichacek Beda; Elliott Julie; Fromentin Emilie; Shattock Robin; Anton Peter; Gorelick Robert; Balzarini Jan; McGuigan Christopher; Derudas Marco; Götte Matthias; Schinazi Raymond F; Margolis Leonid
Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues.
Cell host & microbe 2008;4(3):260-70.
2008: Yurdaydin C; Bozkaya H; Onder F O; Sentürk H; Karaaslan H; Akdogan M; Cetinkaya H; Erden E; Erkan-Esin O; Yalçin K; Bozdayi A M; Schinazi R F; Gerin J L; Uzunalimoglu O; Ozden A
Treatment of chronic delta hepatitis with lamivudine vs lamivudine + interferon vs interferon.
Journal of viral hepatitis 2008;15(4):314-21.
2008: Bowling John J; Pennaka Hari K; Ivey Kelly; Wahyuono Subagus; Kelly Michelle; Schinazi Raymond F; Valeriote Frederick A; Graves David E; Hamann Mark T
Antiviral and anticancer optimization studies of the DNA-binding marine natural product aaptamine.
Chemical biology & drug design 2008;71(3):205-15.
2008: García-Lerma J Gerardo; Otten Ron A; Qari Shoukat H; Jackson Eddie; Cong Mian-Er; Masciotra Silvina; Luo Wei; Kim Caryn; Adams Debra R; Monsour Michael; Lipscomb Jonathan; Johnson Jeffrey A; Delinsky David; Schinazi Raymond F; Janssen Robert; Folks Thomas M; Heneine Walid
Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir.
PLoS medicine 2008;5(2):e28.
2008: Domaoal Robert A; McMahon Moira; Thio Chloe L; Bailey Christopher M; Tirado-Rives Julian; Obikhod Aleksander; Detorio Mervi; Rapp Kimberly L; Siliciano Robert F; Schinazi Raymond F; Anderson Karen S
Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase.
The Journal of biological chemistry 2008;283(9):5452-9.
2008: Bassit Leda; Grier Jason; Bennett Matthew; Schinazi Raymond F
Combinations of 2'-C-methylcytidine analogues with interferon-alpha2b and triple combination with ribavirin in the hepatitis C virus replicon system.
Antiviral chemistry & chemotherapy 2008;19(1):25-31.
2007: Menne Stephan; Asif Ghazia; Narayanasamy Jannan; Butler Scott D; George Andrea L; Hurwitz Selwyn J; Schinazi Raymond F; Chu Chung K; Cote Paul J; Gerin John L; Tennant Bud C
Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection.
Antimicrobial agents and chemotherapy 2007;51(9):3177-84.
2007: Narayanasamy Janarthanan; Pullagurla Manik R; Sharon Ashoke; Wang Jianing; Schinazi Raymond F; Chu Chung K
Synthesis and anti-HIV activity of (-)-beta-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (-)-beta-D-(2R,4R)-1,3-dioxolane guanosine (DXG) prodrugs.
Antiviral research 2007;75(3):198-209.
2007: Amblard Franck; Govindarajan Baskaran; Lefkove Benjamin; Rapp Kimberly L; Detorio Mervi; Arbiser Jack L; Schinazi Raymond F
Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
Bioorganic & medicinal chemistry letters 2007;17(16):4428-31.
2007: Asif Ghazia; Hurwitz Selwyn J; Shi Junxing; Hernandez-Santiago Brenda I; Schinazi Raymond F
Pharmacokinetics of the antiviral agent beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 2007;51(8):2877-82.
2007: Asif Ghazia; Hurwitz Selwyn J; Obikhod Aleksandr; Delinsky David; Narayanasamy Janarthanan; Chu Chung K; McClure Harold M; Schinazi Raymond F
Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys.
Antimicrobial agents and chemotherapy 2007;51(7):2424-9.
2007: Li Yongfeng; Mao Shuli; Hager Michael W; Becnel Kimberlynne D; Schinazi Raymond F; Liotta Dennis C
Synthesis and evaluation of 2'-substituted cyclobutyl nucleosides and nucleotides as potential anti-HIV agents.
Bioorganic & medicinal chemistry letters 2007;17(12):3398-401.
2007: Lennerstrand Johan; Chu Chung K; Schinazi Raymond F
Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate.
Antimicrobial agents and chemotherapy 2007;51(6):2078-84.
2007: Hernandez-Santiago Brenda I; Mathew Judy S; Rapp Kim L; Grier Jason P; Schinazi Raymond F
Antiviral and cellular metabolism interactions between Dexelvucitabine and lamivudine.
Antimicrobial agents and chemotherapy 2007;51(6):2130-5.
2007: Wang Jianing; Jin Yunho; Rapp Kimberly L; Schinazi Raymond F; Chu Chung K
D- and L-2',3'-didehydro-2',3'-dideoxy-3'-fluoro-carbocyclic nucleosides: synthesis, anti-HIV activity and mechanism of resistance.
Journal of medicinal chemistry 2007;50(8):1828-39.
2007: Patil Shivaputra; Kamath Shantaram; Sanchez Tino; Neamati Nouri; Schinazi Raymond F; Buolamwini John K
Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry 2007;15(3):1212-28.
2007: Murakami Eisuke; Bao Haiying; Ramesh Mangala; McBrayer Tamara R; Whitaker Tony; Micolochick Steuer Holly M; Schinazi Raymond F; Stuyver Lieven J; Obikhod Aleksandr; Otto Michael J; Furman Phillip A
Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.
Antimicrobial agents and chemotherapy 2007;51(2):503-9.
2007: Rao Jagadeeshwar R; Schinazi Raymond F; Chu Chung K
Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides.
Bioorganic & medicinal chemistry 2007;15(2):839-46.
2007: Hernandez-Santiago Brenda I; Obikhod Aleksandr; Fromentin Emilie; Hurwitz Selwyn J; Schinazi Raymond F
Short communication cellular pharmacology of 9-(beta-D-1,3-dioxolan-4-yl) guanine and its lack of drug interactions with zidovudine in primary human lymphocytes.
Antiviral chemistry & chemotherapy 2007;18(6):343-6.
2007: Hurwitz Selwyn J; Asif Ghazia; Schinazi Raymond F
Development of a population simulation model for HIV monotherapy virological outcomes using lamivudine.
Antiviral chemistry & chemotherapy 2007;18(6):329-41.
2007: Feitelson Mark A; Clayton Marcia M; Sun Bill; Schinazi Raymond F
Development of a novel mouse model to evaluate drug candidates against hepatitis B virus.
Antiviral chemistry & chemotherapy 2007;18(4):213-23.
2007: Ray Adrian S; Feng Joy Y; Murakami Eisuke; Chu Chung K; Schinazi Raymond F; Anderson Karen S
Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma.
Antiviral chemistry & chemotherapy 2007;18(1):25-33.
2007: Chun Byoung-Kwon; Wang Peiyuan; Hassan Abdalla; Du Jinfa; Tharnish Phillip M; Murakami Eisuke; Stuyver Lieven; Otto Michael J; Schinazi Raymond F; Watanabe Kyoichi A
Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.
Nucleosides, nucleotides & nucleic acids 2007;26(1):83-97.
2006: Gul Waseem; Hammond Nicholas L; Yousaf Muhammad; Bowling John J; Schinazi Raymond F; Wirtz Susan S; de Castro Andrews Garcia; Cuevas Carmen; Hamann Mark T
Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity.
Bioorganic & medicinal chemistry 2006;14(24):8495-505.
2006: Zhang Hongwang; Schinazi Raymond F; Chu Chung K
Synthesis of neplanocin F analogues as potential antiviral agents.
Bioorganic & medicinal chemistry 2006;14(24):8314-22.
2006: Al Safarjalani Omar N; Rais Reem; Shi Junxing; Schinazi Raymond F; Naguib Fardos N M; el Kouni Mahmoud H
Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor.
Cancer chemotherapy and pharmacology 2006;58(5):692-8.
2006: Schinazi Raymond F; Hernandez-Santiago Brenda I; Hurwitz Selwyn J
Pharmacology of current and promising nucleosides for the treatment of human immunodeficiency viruses.
Antiviral research 2006;71(2-3):322-34.
2006: Amblard Franck; Delinsky David; Arbiser Jack L; Schinazi Raymond F
Facile purification of honokiol and its antiviral and cytotoxic properties.
Journal of medicinal chemistry 2006;49(11):3426-7.
2006: Liang Yuzeng; Narayanasamy Janarthanan; Schinazi Raymond F; Chu Chung K
Phosphoramidate and phosphate prodrugs of (-)-beta-D-(2R,4R)-dioxolane-thymine: synthesis, anti-HIV activity and stability studies.
Bioorganic & medicinal chemistry 2006;14(7):2178-89.
2006: Choo Hyunah; Chen Xin; Yadav Vikas; Wang Jianing; Schinazi Raymond F; Chu Chung K
Synthesis and anti-HIV activity of D- and L-thietanose nucleosides.
Journal of medicinal chemistry 2006;49(5):1635-47.
2006: Clark Jeremy L; Mason J Christian; Hollecker Laurent; Stuyver Lieven J; Tharnish Phillip M; McBrayer Tamara R; Otto Michael J; Furman Phillip A; Schinazi Raymond F; Watanabe Kyoichi A
Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.
Bioorganic & medicinal chemistry letters 2006;16(6):1712-5.
2006: Liang Yuzeng; Narayanasamy Janarthanan; Rapp Kim L; Schinazi Raymond F; Chu Chung K
PAMAM dendrimers and branched polyethyleneglycol (nanoparticles) prodrugs of (-)-beta-D-(2R, 4R)-dioxolane-thymine (DOT) and their anti-HIV activity.
Antiviral chemistry & chemotherapy 2006;17(6):321-9.
2006: Stuyver Lieven J; McBrayer Tamara R; Tharnish Phillip M; Clark Jeremy; Hollecker Laurent; Lostia Stefania; Nachman Tammy; Grier Jason; Bennett Matthew A; Xie Meng-Yu; Schinazi Raymond F; Morrey John D; Julander Justin L; Furman Phillip A; Otto Michael J
Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.
Antiviral chemistry & chemotherapy 2006;17(2):79-87.
2005: Escuret Vanessa; Aucagne Vincent; Joubert Nicolas; Durantel David; Rapp Kimberly L; Schinazi Raymond F; Zoulim Fabien; Agrofoglio Luigi A
Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: antiviral activity and cellular toxicity.
Bioorganic & medicinal chemistry 2005;13(21):6015-24.
2005: Wang Peiyuan; Du Jinfa; Rachakonda Suguna; Chun Byoung-Kwon; Tharnish Phillip M; Stuyver Lieven J; Otto Michael J; Schinazi Raymond F; Watanabe Kyoichi A
Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives.
Journal of medicinal chemistry 2005;48(20):6454-60.
2005: Moore Casey; Hernández-Santiago Brenda I; Hurwitz Selwyn J; Tan Chalet; Wang Chris; Schinazi Raymond F
The boron-neutron capture agent beta-D-5-o-carboranyl-2'-deoxyuridine accumulates preferentially in dividing brain tumor cells.
Journal of neuro-oncology 2005;74(3):275-80.
2005: Hammond Jennifer L; Parikh Urvi M; Koontz Dianna L; Schlueter-Wirtz Susan; Chu Chung K; Bazmi Hengameh Z; Schinazi Raymond F; Mellors John W
In vitro selection and analysis of human immunodeficiency virus type 1 resistant to derivatives of beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine.
Antimicrobial agents and chemotherapy 2005;49(9):3930-2.
2005: Williams Kenneth; Westmoreland Susan; Greco Jane; Ratai Eva; Lentz Margaret; Kim Woong-Ki; Fuller Robert A; Kim John P; Autissier Patrick; Sehgal Prahbat K; Schinazi Raymond F; Bischofberger Norbert; Piatak Michael; Lifson Jeffrey D; Masliah Eliezer; González R Gilberto
Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.
The Journal of clinical investigation 2005;115(9):2534-45.
2005: Clark Jeremy L; Hollecker Laurent; Mason J Christian; Stuyver Lieven J; Tharnish Phillip M; Lostia Stefania; McBrayer Tamara R; Schinazi Raymond F; Watanabe Kyoichi A; Otto Michael J; Furman Phillip A; Stec Wojciech J; Patterson Steven E; Pankiewicz Krzysztof W
Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.
Journal of medicinal chemistry 2005;48(17):5504-8.
2005: Moser Michael J; Ruckstuhl Meta; Larsen Christine A; Swearingen Amanda J; Kozlowski Miroslaw; Bassit Leda; Sharma Prem L; Schinazi Raymond F; Prudent James R
Quantifying mixed populations of drug-resistant human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 2005;49(8):3334-40.
2005: Sluis-Cremer Nicolas; Arion Dominique; Parikh Urvi; Koontz Dianna; Schinazi Raymond F; Mellors John W; Parniak Michael A
The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.
The Journal of biological chemistry 2005;280(32):29047-52.
2005: Herzmann C; Arastèh K; Murphy R L; Schulbin H; Kreckel P; Drauz D; Schinazi R F; Beard A; Cartee L; Otto M J
Safety, pharmacokinetics, and efficacy of (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine with efavirenz and stavudine in antiretroviral-naïve human immunodeficiency virus-infected patients.
Antimicrobial agents and chemotherapy 2005;49(7):2828-33.
2005: Pai S Balakrishna; Bozdayi A Mithat; Pai Rekha B; Beker Tolunay; Sarioglu Mustafa; Turkyilmaz Ahmet R; Grier Jason; Yurdaydin Cihan; Schinazi Raymond F
Emergence of a novel mutation in the FLLA region of hepatitis B virus during lamivudine therapy.
Antimicrobial agents and chemotherapy 2005;49(7):2618-24.
2005: Hernandez-Santiago Brenda I; Chen Huachun; Asif Ghazia; Beltran Thierry; Mao Shuli; Hurwitz Selwyn J; Grier Jason; McClure Harold M; Chu Chung K; Liotta Dennis C; Schinazi Raymond F
Pharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeys.
Antimicrobial agents and chemotherapy 2005;49(7):2589-97.
2005: Lesnikowski Zbigniew J; Paradowska Edyta; Olejniczak Agnieszka B; Studzinska Miroslawa; Seekamp Petra; Schüssler Uw; Gabel Detlef; Schinazi Raymond F; Plesek Jaromir
Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates.
Bioorganic & medicinal chemistry 2005;13(13):4168-75.
2005: Chu Chung K; Yadav Vikas; Chong Youhoon H; Schinazi Raymond F
Anti-HIV activity of (-)-(2R,4R)-1- (2-hydroxymethyl-1,3-dioxolan-4-yl)-thymine against drug-resistant HIV-1 mutants and studies of its molecular mechanism.
Journal of medicinal chemistry 2005;48(12):3949-52.
2005: North Thomas W; Van Rompay Koen K A; Higgins Joanne; Matthews Timothy B; Wadford Debra A; Pedersen Niels C; Schinazi Raymond F
Suppression of virus load by highly active antiretroviral therapy in rhesus macaques infected with a recombinant simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.
Journal of virology 2005;79(12):7349-54.
2005: Wang Jianing; Jin Yunho; Rapp Kimberly L; Bennett Matthew; Schinazi Raymond F; Chu Chung K
Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides.
Journal of medicinal chemistry 2005;48(11):3736-48.
2005: Rossi Simona; Schinazi Raymond F; Martini Giacomo
ESR as a valuable tool for the investigation of the dynamics of EPC and EPC/cholesterol liposomes containing a carboranyl-nucleoside intended for BNCT.
Biochimica et biophysica acta 2005;1712(1):81-91.
2005: Al Safarjalani Omar N; Zhou Xiao-Jian; Rais Reem H; Shi Junxing; Schinazi Raymond F; Naguib Fardos N M; El Kouni Mahmoud H
5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens.
Cancer chemotherapy and pharmacology 2005;55(6):541-51.
2005: Ray Adrian S; Hernandez-Santiago Brenda I; Mathew Judy S; Murakami Eisuke; Bozeman Carey; Xie Meng-Yu; Dutschman Ginger E; Gullen Elizabeth; Yang Zhenjun; Hurwitz Selwyn; Cheng Yung-Chi; Chu Chung K; McClure Harold; Schinazi Raymond F; Anderson Karen S
Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosine.
Antimicrobial agents and chemotherapy 2005;49(5):1994-2001.
2005: Parikh Urvi M; Koontz Dianna L; Chu Chung K; Schinazi Raymond F; Mellors John W
In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase.
Antimicrobial agents and chemotherapy 2005;49(3):1139-44.
2005: Shi Junxing; Du Jinfa; Ma Tianwei; Pankiewicz Krzysztof W; Patterson Steven E; Tharnish Phillip M; McBrayer Tamara R; Stuyver Lieven J; Otto Michael J; Chu Chung K; Schinazi Raymond F; Watanabe Kyoichi A
Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.
Bioorganic & medicinal chemistry 2005;13(5):1641-52.
2005: Likhitwitayawuid Kittisak; Sritularak Boonchoo; Benchanak Kanokwan; Lipipun Vimolmas; Mathew Judy; Schinazi Raymond F
Phenolics with antiviral activity from Millettia erythrocalyx and Artocarpus lakoocha.
Natural product research 2005;19(2):177-82.
2005: Asif Ghazia; Hurwitz Selwyn J; Gumina Giuseppe; Chu Chung K; McClure Harold M; Schinazi Raymond F
Pharmacokinetics of the antiviral agent beta-L-3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 2005;49(2):560-4.
2005: Amblard Franck; Aucagne Vincent; Guenot Pierre; Schinazi Raymond F; Agrofoglio Luigi A
Synthesis and antiviral activity of novel acyclic nucleosides in the 5-alkynyl- and 6-alkylfuro[2,3-d]pyrimidine series.
Bioorganic & medicinal chemistry 2005;13(4):1239-48.
2005: Gadthula Srinivas; Chu Chung K; Schinazi Raymond F
Synthesis and anti-HIV activity of beta-D-3'-azido-2',3'-unsaturated nucleosides and beta-D-3'-azido-3'-deoxyribofuranosylnucleosides.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1707-27.
2005: Hassan Abdalla E A; Wang Peiyuan; McBrayer Tamara; Tharnish Philip; Stuyver Lieven; Otto Michael J; Watanabe Kyoichi A; Schinazi Raymond F
Synthesis and anti-HCV activity of N9,5'-cyclo-3-(beta-D-ribofuranosyl)-8-azapurin-2-one derivatives.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1531-42.
2005: Hassan Abdalla E A; Wang Peiyuan; McBrayer Tamara R; Tharnish Phillip M; Stuyver Lieven J; Schinazi Raymond F; Otto Michael J; Watanabe Kyoichi A
Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3, 5'-anhydro-4-(beta-D-ribofuranosyl)-8-aza-purin-2-ones.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):961-4.
2005: Wang Peiyuan; Hollecker Laurent; Pankiewicz Krzysztof W; Patterson Steven E; Whitaker Tony; McBrayer Tamara R; Tharnish Phillip M; Stuyver Lieven J; Schinazi Raymond F; Otto Michael J; Watanabe Kyoichi A
Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):957-60.
2005: Shi Junxing; Du Jinfa; Ma Tianwei; Pankiewicz Krzysztof W; Patterson Steven E; Hassan Abdalla E A; Tharnish Phillip M; McBrayer Tamaia R; Lostia Stefania; Stuyver Lieven J; Watanabe Kyoichi A; Chu Chung K; Schinazi Raymond F; Otto Michael J
Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):875-9.
2005: Pai S Balakrishna; Pai Rekha B; Xie Meng-yu; Beker Tolunay; Shi Junxing; Tharnish Philip M; Chu Chung K; Schinazi Raymond F
Characterization of hepatitis B virus inhibition by novel 2'-fluoro-2',3'-unsaturated beta-D- and L-nucleosides.
Antiviral chemistry & chemotherapy 2005;16(3):183-92.
2005: Sharma Prem L; Nurpeisov Viktoria; Schinazi Raymond F
Retrovirus reverse transcriptases containing a modified YXDD motif.
Antiviral chemistry & chemotherapy 2005;16(3):169-82.
2005: Hurwitz Selwyn J; Otto Michael J; Schinazi Raymond F
Comparative pharmacokinetics of Racivir, (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats, rabbits, dogs, monkeys and HIV-infected humans.
Antiviral chemistry & chemotherapy 2005;16(2):117-27.
2004: Hernandez-Santiago Brenda I; Beltran Thierry; Stuyver Lieven; Chu Chung K; Schinazi Raymond F
Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells.
Antimicrobial agents and chemotherapy 2004;48(12):4636-42.
2004: Wang Peiyuan; Hollecker Laurent; Pankiewicz Krzysztof W; Patterson Steven E; Whitaker Tony; McBrayer Tamara R; Tharnish Phillip M; Sidwell Robert W; Stuyver Lieven J; Otto Michael J; Schinazi Raymond F; Watanabe Kyoichi A
Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.
Journal of medicinal chemistry 2004;47(24):6100-3.
2004: Mao Shuli; Bouygues Martin; Welch Christopher; Biba Mirlinda; Chilenski Jen; Schinazi Raymond F; Liotta Dennis C
Synthesis of enantiomerically pure D-FDOC, an anti-HIV agent.
Bioorganic & medicinal chemistry letters 2004;14(19):4991-4.
2004: Chen Xin; Zhou Wen; Schinazi Raymond F; Chu Chung K
Synthesis of 3'-fluoro-2',3'-dideoxy-2',3'-didehydro-4'-ethynyl-D- and -L-furanosyl nucleosides.
The Journal of organic chemistry 2004;69(18):6034-41.
2004: Hofman Michael J; Higgins Joanne; Matthews Timothy B; Pedersen Niels C; Tan Chalet; Schinazi Raymond F; North Thomas W
Efavirenz therapy in rhesus macaques infected with a chimera of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 2004;48(9):3483-90.
2004: Stuyver Lieven J; McBrayer Tamara R; Schürmann Dirk; Kravec Irena; Beard Amanda; Cartee Leanne; Schinazi Raymond F; De La Rosa Abel; Murphy Robert L; Otto Michael J
Potent antiviral effect of reverset in HIV-1-infected adults following a single oral dose.
Antiviral therapy 2004;9(4):529-36.
2004: Rao Karumanchi V; Kasanah Noer; Wahyuono Subagus; Tekwani Babu L; Schinazi Raymond F; Hamann Mark T
Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases.
Journal of natural products 2004;67(8):1314-8.
2004: Bondada Lavanya; Gumina Giuseppe; Nair Ranjeet; Ning Xing Hai; Schinazi Raymond F; Chu Chung K
Synthesis of novel spiro[2.3]hexane carbocyclic nucleosides via enzymatic resolution.
Organic letters 2004;6(15):2531-4.
2004: Zhou Wen; Gumina Giuseppe; Chong Youhoon; Wang Jianing; Schinazi Raymond F; Chu Chung K
Synthesis, structure-activity relationships, and drug resistance of beta-d-3'-fluoro-2',3'-unsaturated nucleosides as anti-HIV Agents.
Journal of medicinal chemistry 2004;47(13):3399-408.
2004: Shi Junxing; Ray Adrian S; Mathew Judy S; Anderson Karen S; Chu Chung K; Schinazi Raymond F
2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions.
Bioorganic & medicinal chemistry letters 2004;14(9):2159-62.
2004: Pankiewicz Krzysztof W; Patterson Steven E; Black Paul L; Jayaram Hiremagalur N; Risal Dipesh; Goldstein Barry M; Stuyver Lieven J; Schinazi Raymond F
Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.
Current medicinal chemistry 2004;11(7):887-900.
2004: Sharma Prem L; Nurpeisov Viktoria; Lee Kimberly; Skaggs Sara; Di San Filippo Christina Amat; Schinazi Raymond F
Replication-dependent 65R-->K reversion in human immunodeficiency virus type 1 reverse transcriptase double mutant K65R + L74V.
Virology 2004;321(2):222-34.
2004: Feng Joy Y; Murakami Eisuke; Zorca Suzana M; Johnson Allison A; Johnson Kenneth A; Schinazi Raymond F; Furman Phillip A; Anderson Karen S
Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase.
Antimicrobial agents and chemotherapy 2004;48(4):1300-6.
2004: Murakami Eisuke; Ray Adrian S; Schinazi Raymond F; Anderson Karen S
Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP.
Antiviral research 2004;62(1):57-64.
2004: Zhu Wei; Chong Youhoon; Choo Hyunah; Mathews Judy; Schinazi Raymond F; Chu Chung K
Synthesis, structure-activity relationships, and mechanism of drug resistance of D- and L-beta-3'-fluoro-2',3'-unsaturated-4'-thionucleosides as anti-HIV agents.
Journal of medicinal chemistry 2004;47(7):1631-40.
2004: Stuyver Lieven J; McBrayer Tamara R; Whitaker Tony; Tharnish Phillip M; Ramesh Mangala; Lostia Stefania; Cartee Leanne; Shi Junxing; Hobbs Ann; Schinazi Raymond F; Watanabe Kyoichi A; Otto Michael J
Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.
Antimicrobial agents and chemotherapy 2004;48(2):651-4.
2004: Hollecker Laurent; Choo Hyunah; Chong Youhoon; Chu Chung K; Lostia Stefania; McBrayer Tamara R; Stuyver Lieven J; Mason J Christian; Du Jinfa; Rachakonda Suguna; Shi Junxing; Schinazi Raymond F; Watanabe Kyochi A
Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture.
Antiviral chemistry & chemotherapy 2004;15(1):43-55.
2004: Sharma Prem L; Nurpeisov Viktoria; Hernandez-Santiago Brenda; Beltran Thierry; Schinazi Raymond F
Nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase.
Current topics in medicinal chemistry 2004;4(9):895-919.
2004: Schinazi Raymond F; Hurwitz Selwyn J; Liberman Irina; Glazkova Yuliya; Mourier Nicolas S; Olson Jeffrey; Keane Thomas
Tissue disposition of 5-o-carboranyluracil--a novel agent for the boron neutron capture therapy of prostate cancer.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):291-306.
2004: Feitelson Mark A; Larkin Jonathan D; Schinazi Raymond F
Hepatitis B virus transgenic severe combined immunodeficient mouse model of acute and chronic liver disease.
Methods in molecular medicine 2004;96():269-87.
2003: Chong Youhoon; Stuyver Lieven; Otto Michael J; Schinazi Raymond F; Chu Chung K
Mechanism of antiviral activities of 3'-substituted L-nucleosides against 3TC-resistant HBV polymerase: a molecular modelling approach.
Antiviral chemistry & chemotherapy 2003;14(6):309-19.
2003: Peng Jiangnan; Hu Jin-Feng; Kazi Abul B; Li Ze; Avery Mitchell; Peraud Olivier; Hill Russell T; Franzblau Scott G; Zhang Fangqiu; Schinazi Raymond F; Wirtz Susan S; Tharnish Phillip; Kelly Michelle; Wahyuono Subagus; Hamann Mark T
Manadomanzamines A and B: a novel alkaloid ring system with potent activity against mycobacteria and HIV-1.
Journal of the American Chemical Society 2003;125(44):13382-6.
2003: Schinazi Raymond F
Assessment of the relative potency of emtricitabine and lamivudine.
Journal of acquired immune deficiency syndromes (1999) 2003;34(2):243-5; author reply 245-6.
2003: Stuyver Lieven J; McBrayer Tamara R; Tharnish Phillip M; Hassan Abdalla E A; Chu Chung K; Pankiewicz Krzysztof W; Watanabe Kyochi A; Schinazi Raymond F; Otto Michael J
Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites.
Journal of virology 2003;77(19):10689-94.
2003: Pai S B; Pai R B; Schinazi R F
Treatment modalities for hepatitis B viral infection and resistance to antiviral therapy.
Panminerva medica 2003;45(3):165-73.
2003: Saito Yoshio; Escuret Vanessa; Durantel David; Zoulim Fabien; Schinazi Raymond F; Agrofoglio Luigi A
Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon.
Bioorganic & medicinal chemistry 2003;11(17):3633-9.
2003: Gochfeld D J; El Sayed K A; Yousaf M; Hu J F; Bartyzel P; Dunbar D C; Wilkins S P; Zjawiony J K; Schinazi R F; Schlueter Wirtz S; Tharnish P M; Hamann M T
Marine natural products as lead anti-HIV agents.
Mini reviews in medicinal chemistry 2003;3(5):401-24.
2003: Ray Adrian S; Murakami Eisuke; Basavapathruni Aravind; Vaccaro Joseph A; Ulrich Dagny; Chu Chung K; Schinazi Raymond F; Anderson Karen S
Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis.
Biochemistry 2003;42(29):8831-41.
2003: Chong Youhoon; Gumina Giuseppe; Mathew Judy S; Schinazi Raymond F; Chu Chung K
l-2',3'-Didehydro-2',3'-dideoxy-3'-fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance.
Journal of medicinal chemistry 2003;46(15):3245-56.
2003: Bozdayi A M; Uzunalimoglu O; Türkyilmaz A R; Aslan N; Sezgin O; Sahin T; Bozdayi G; Cinar K; Pai S B; Pai R; Bozkaya H; Karayalçin S; Yurdaydin C; Schinazi R F
YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine.
Journal of viral hepatitis 2003;10(4):256-65.
2003: Rao Karumanchi V; Santarsiero Bernard D; Mesecar Andrew D; Schinazi Raymond F; Tekwani Babu L; Hamann Mark T
New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge.
Journal of natural products 2003;66(6):823-8.
2003: Chen Huachun; Pai S Balakrishna; Hurwitz Selwyn J; Chu Chung K; Glazkova Yuliya; McClure Harold M; Feitelson Mark; Schinazi Raymond F
Antiviral activity and pharmacokinetics of 1-(2,3-dideoxy-2-fluoro-beta-L-glyceropent-2-enofuranosyl)cytosine.
Antimicrobial agents and chemotherapy 2003;47(6):1922-8.
2003: Hassan Abdalla E A; Pai Balakrina S; Lostia Stefania; Stuyver Lieven; Otto Michael J; Schinazi Raymond F; Watanabe Kyoichi A
Synthesis and antiviral evaluation of 2',3'-dideoxy-2'-fluoro-3'- C-hydroxymethyl-beta-D-arabinofuranosyl pyrimidine nucleosides.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):891-4.
2003: Chong Youhoon; Choo Hyunah; Schinazi Raymond F; Chu Chung K
2'-Fluoro-4'-thio-2',3'-unsaturated nucleosides: anti-HIV activity, resistance profile, and molecular modeling studies.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):611-5.
2003: Ray Adrian S; Schinazi Raymond F; Murakami Eisuke; Basavapathruni Aravind; Shi Junxing; Zorca Suzana M; Chu Chung K; Anderson Karen S
Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase.
Antiviral chemistry & chemotherapy 2003;14(3):115-25.
2003: Shi Junxing; Mathew Judy S; Tharnish Phillip M; Rachakonda Suguna; Pai S Balakrishna; Adams Marjorie; Grier Jason P; Gallagher Karen; Zhang Hangchun; Wu Jing-Tao; Shi Guoen; Geleziunas Romas; Erickson-Viitanen Susan; Stuyver Lieven; Otto Michael J; Watanabe Kyoichi A; Schinazi Raymond F
N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity.
Antiviral chemistry & chemotherapy 2003;14(2):81-90.
2003: Geleziunas Romas; Gallagher Karen; Zhang Hangchun; Bacheler Lee; Garber Sena; Wu Jing-Tao; Shi Guoen; Otto Michael J; Schinazi Raymond F; Erickson-Viitanen Susan
HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset).
Antiviral chemistry & chemotherapy 2003;14(1):49-59.
2003: Erickson-Viitanen Susan; Wu Jing-Tao; Shi Guoen; Unger Steven; King Robert W; Fish Barbara; Klabe Ronald; Geleziunas Romas; Gallagher Karen; Otto Michael J; Schinazi Raymond F
Cellular pharmacology of D-d4FC, a nucleoside analogue active against drug-resistant HIV.
Antiviral chemistry & chemotherapy 2003;14(1):39-47.
2003: Choo Hyunah; Chong Youhoon; Choi Yongseok; Mathew Judy; Schinazi Raymond F; Chu Chung K
Synthesis, anti-HIV activity, and molecular mechanism of drug resistance of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.
Journal of medicinal chemistry 2003;46(3):389-98.
2003: Stuyver Lieven J; Whitaker Tony; McBrayer Tamara R; Hernandez-Santiago Brenda I; Lostia Stefania; Tharnish Phillip M; Ramesh Mangala; Chu Chung K; Jordan Robert; Shi Junxing; Rachakonda Suguna; Watanabe Kyoichi A; Otto Michael J; Schinazi Raymond F
Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.
Antimicrobial agents and chemotherapy 2003;47(1):244-54.
2002: Kocabalkanli Ayse; Schinazi Raymond F
Synthesis of oxathiolane imidazole nucleosides.
Farmaco (Società chimica italiana : 1989) 2002;57(12):993-7.
2002: Stuyver Lieven J; Lostia Stefania; Adams Marjorie; Mathew Judy S; Pai Balakrishna S; Grier Jason; Tharnish Phillip M; Choi Yongseok; Chong Youhoon; Choo Hyunah; Chu Chung K; Otto Michael J; Schinazi Raymond F
Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.
Antimicrobial agents and chemotherapy 2002;46(12):3854-60.
2002: Ray Adrian S; Murakami Eisuke; Peterson Celeste N; Shi Junxing; Schinazi Raymond F; Anderson Karen S
Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase.
Antiviral research 2002;56(3):189-205.
2002: Hurwitz Selwyn J; Schinazi Raymond F
Development of a pharmacodynamic model for HIV treatment with nucleoside reverse transcriptase and protease inhibitors.
Antiviral research 2002;56(2):115-27.
2002: Chong Youhoon; Choo Hyunah; Choi Yongseok; Mathew Judy; Schinazi Raymond F; Chu Chung K
Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides.
Journal of medicinal chemistry 2002;45(22):4888-98.
2002: Tatti Kathleen M; Korba Brent E; Stang Heather L; Peek Simon; Gerin John L; Tennant Bud C; Schinazi Raymond F
Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine.
Antiviral research 2002;55(1):141-50.
2002: Kalichman S C; Rompa D; Cage M; Austin J; Luke W; Barnett T; Tharnish P; Mowrey J; Schinazi R F
Sexual transmission risk perceptions and behavioural correlates of HIV concentrations in semen.
AIDS care 2002;14(3):343-9.
2002: Van Rompay Koen K A; Matthews Tim B; Higgins Joanne; Canfield Don R; Tarara Ross P; Wainberg Mark A; Schinazi Raymond F; Pedersen Niels C; North Thomas W
Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase.
Journal of virology 2002;76(12):6083-92.
2002: Hurwitz Selwyn J; Tennant Bud C; Korba Brent E; Liberman Irina; Gerin John L; Schinazi Raymond F
Viral pharmacodynamic model for (-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine (emtricitabine) in chronically infected woodchucks.
Antiviral chemistry & chemotherapy 2002;13(3):165-76.
2002: Liu Xuefeng; Schinazi Raymond F
Hepatitis B virus resistance to lamivudine and its clinical implications.
Antiviral chemistry & chemotherapy 2002;13(3):143-55.
2002: Schinazi Raymond F; Mellors John; Bazmi Holly; Diamond Sharon; Garber Sena; Gallagher Karen; Geleziunas Romas; Klabe Ron; Pierce Michael; Rayner Marlene; Wu Jing-Tao; Zhang Hangchun; Hammond Jennifer; Bacheler Lee; Manion Douglas J; Otto Michael J; Stuyver Lieven; Trainor George; Liotta Dennis C; Erickson-Viitanen Susan
DPC 817: a cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants.
Antimicrobial agents and chemotherapy 2002;46(5):1394-401.
2002: Ray Adrian S; Yang Zhenjun; Shi Junxing; Hobbs Ann; Schinazi Raymond F; Chu Chung K; Anderson Karen S
Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate.
Biochemistry 2002;41(16):5150-62.
2002: Chong Youhoon; Borroto-Esoda Katyna; Furman Phillip A; Schinazi Raymond F; Chu Chung K
Molecular mechanism of DApd/DXG against zidovudine- and lamivudine- drug resistant mutants: a molecular modelling approach.
Antiviral chemistry & chemotherapy 2002;13(2):115-28.
2002: Lee Kyeong; Choi Yongseok; Gumina Giuseppe; Zhou Wen; Schinazi Raymond F; Chu Chung K
Structure-activity relationships of 2'-fluoro-2',3'-unsaturated D-nucleosides as anti-HIV-1 agents.
Journal of medicinal chemistry 2002;45(6):1313-20.
2002: Marzabadi Cecilia H; Franck Richard W; Schinazi Raymond F
The synthesis and biological evaluation of novel bridging nucleoside analogues.
Bioorganic & medicinal chemistry 2002;10(2):273-81.
2002: Choi Yongseok; Choo Hyunah; Chong Youhoon; Lee Sookwang; Olgen Sureyya; Schinazi Raymond F; Chu Chung K
Synthesis and potent anti-HIV activity of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine.
Organic letters 2002;4(2):305-7.
2001: Kalichman S C; Cage M; Barnett T; Tharnish P; Rompa D; Austin J; Luke W; O'Mowrey J; Schinazi R F
Human immunodeficiency virus in semen and plasma: investigation of sexual transmission risk behavioral correlates.
AIDS research and human retroviruses 2001;17(18):1695-703.
2001: Gumina G; Schinazi R F; Chu C K
Synthesis and potent anti-HIV activity of L-3'-fluoro-2',3'-unsaturated cytidine.
Organic letters 2001;3(26):4177-80.
2001: Al Safarjalani O N; Zhou X J; Naguib F N; Shi J; Schinazi R F; el Kouni M H
Enhancement of the bioavailability of oral uridine by coadministration of 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for uridine rescue regimens in chemotherapy.
Cancer chemotherapy and pharmacology 2001;48(5):389-97.
2001: Song G Y; Paul V; Choo H; Morrey J; Sidwell R W; Schinazi R F; Chu C K
Enantiomeric synthesis of D- and L-cyclopentenyl nucleosides and their antiviral activity against HIV and West Nile virus.
Journal of medicinal chemistry 2001;44(23):3985-93.
2001: Al Safarjalani O N; Zhou X J; Naguib F N; Goudgaon N M; Schinazi R F; el Kouni M H
Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy.
Cancer chemotherapy and pharmacology 2001;48(2):145-50.
2001: Gay I; Lorey D R; Schinazi R F; Morrison G H; Chandra S
Dynamic SIMS ion microscopy imaging of intracellular boron accumulation from carboranyl nucleosides in glioma cells.
Anticancer research 2001;21(4A):2369-75.
2001: Ellerbrock T V; Lennox J L; Clancy K A; Schinazi R F; Wright T C; Pratt-Palmore M; Evans-Strickfaden T; Schnell C; Pai R; Conley L J; Parrish-Kohler E E; Bush T J; Tatti K; Hart C E
Cellular replication of human immunodeficiency virus type 1 occurs in vaginal secretions.
The Journal of infectious diseases 2001;184(1):28-36.
2001: Bryant M L; Bridges E G; Placidi L; Faraj A; Loi A G; Pierra C; Dukhan D; Gosselin G; Imbach J L; Hernandez B; Juodawlkis A; Tennant B; Korba B; Cote P; Cretton-Scott E; Schinazi R F; Sommadossi J P
Anti-HBV specific beta-L-2'-deoxynucleosides.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):597-607.
2001: Shi J; Schinazi R F
Asymmetric synthesis of carbocyclic pyrimidine nucleosides via pi-allylpalladium complex.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):1367-70.
2001: Placidi L; Faraj A; Loi A G; Pierra C; Egron D; Cretton-Scott E; Gosseli G; Périgaud C; Martin L T; Schinazi R F; Imbach J L; el Kouni M H; Bryant M L; Sommadossi J P
Antiviral activity and intracellular metabolism of bis(tButylSATE) phosphotriester of beta-L-2',3'dideoxyadenosine, a potent inhibitor of HIV and HBV replication.
Antiviral chemistry & chemotherapy 2001;12(2):99-108.
2001: Stuyver L J; Locarnini S A; Lok A; Richman D D; Carman W F; Dienstag J L; Schinazi R F
Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region.
Hepatology (Baltimore, Md.) 2001;33(3):751-7.
2001: Judd D A; Nettles J H; Nevins N; Snyder J P; Liotta D C; Tang J; Ermolieff J; Schinazi R F; Hill C L
Polyoxometalate HIV-1 protease inhibitors. A new mode of protease inhibition.
Journal of the American Chemical Society 2001;123(5):886-97.
2001: Ono S K; Kato N; Shiratori Y; Kato J; Goto T; Schinazi R F; Carrilho F J; Omata M
The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance.
The Journal of clinical investigation 2001;107(4):449-55.
2001: Bryant M L; Bridges E G; Placidi L; Faraj A; Loi A G; Pierra C; Dukhan D; Gosselin G; Imbach J L; Hernandez B; Juodawlkis A; Tennant B; Korba B; Cote P; Marion P; Cretton-Scott E; Schinazi R F; Sommadossi J P
Antiviral L-nucleosides specific for hepatitis B virus infection.
Antimicrobial agents and chemotherapy 2001;45(1):229-35.
2001: Furman P A; Jeffrey J; Kiefer L L; Feng J Y; Anderson K S; Borroto-Esoda K; Hill E; Copeland W C; Chu C K; Sommadossi J P; Liberman I; Schinazi R F; Painter G R
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.
Antimicrobial agents and chemotherapy 2001;45(1):158-65.
2001: Schinazi R F; Schlueter-Wirtz S; Stuyver L
Early detection of mixed mutations selected by antiretroviral agents in HIV-infected primary human lymphocytes.
Antiviral chemistry & chemotherapy 2001;12 Suppl 1():61-5.
2001: Standring D N; Bridges E G; Placidi L; Faraj A; Loi A G; Pierra C; Dukhan D; Gosselin G; Imbach J L; Hernandez B; Juodawlkis A; Tennant B; Korba B; Cote P; Cretton-Scott E; Schinazi R F; Myers M; Bryant M L; Sommadossi J P
Antiviral beta-L-nucleosides specific for hepatitis B virus infection.
Antiviral chemistry & chemotherapy 2001;12 Suppl 1():119-29.
2000: Meyer P R; Matsuura S E; Schinazi R F; So A G; Scott W A
Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates.
Antimicrobial agents and chemotherapy 2000;44(12):3465-72.
2000: Chu C K; Ma L; Olgen S; Pierra C; Du J; Gumina G; Gullen E; Cheng Y C; Schinazi R F
Synthesis and antiviral activity of oxaselenolane nucleosides.
Journal of medicinal chemistry 2000;43(21):3906-12.
2000: el Kouni M H; Goudgaon N M; Rafeeq M; Al Safarjalani O N; Schinazi R F; Naguib F N
5-phenylthioacyclouridine: a potent and specific inhibitor of uridine phosphorylase.
Biochemical pharmacology 2000;60(6):851-6.
2000: Ashour O M; Naguib F N; Goudgaon N M; Schinazi R F; el Kouni M H
Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2'-deoxyuridine against murine colon tumor C26-10.
Biochemical pharmacology 2000;60(5):687-92.
2000: Chun B K; Schinazi R F; Cheng Y C; Chu C K
Synthesis of 2',3'-dideoxy-3'-fluoro-L-ribonucleosides as potential antiviral agents from D-sorbitol.
Carbohydrate research 2000;328(1):49-59.
2000: Hong J H; Gao M Y; Choi Y; Cheng Y C; Schinazi R F; Chu C K
Synthesis of novel 3'-C-methyl-apionucleosides: an asymmetric construction of a quaternary carbon by Claisen rearrangement.
Carbohydrate research 2000;328(1):37-48.
2000: Bazmi H Z; Hammond J L; Cavalcanti S C; Chu C K; Schinazi R F; Mellors J W
In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine.
Antimicrobial agents and chemotherapy 2000;44(7):1783-8.
2000: Korba B E; Schinazi R F; Cote P; Tennant B C; Gerin J L
Effect of oral administration of emtricitabine on woodchuck hepatitis virus replication in chronically infected woodchucks.
Antimicrobial agents and chemotherapy 2000;44(6):1757-60.
2000: Ross S A; Weete J D; Schinazi R F; Wirtz S S; Tharnish P; Scheuer P J; Hamann M T
Mololipids, a new series of anti-HIV bromotyramine-derived compounds from a sponge of the order verongida.
Journal of natural products 2000;63(4):501-3.
2000: Placidi L; Cretton-Scott E; Gosselin G; Pierra C; Schinazi R F; Imbach J L; el Kouni M H; Sommadossi J P
Intracellular metabolism of beta-L-2',3'-dideoxyadenosine: relevance to its limited antiviral activity.
Antimicrobial agents and chemotherapy 2000;44(4):853-8.
2000: Hurwitz S J; Ma L; Eleuteri A; Wright J; Moravek J; Schinazi R F
Cellular pharmacology of the D- and L-enantiomers of beta-5-o-carboranyl-2'-deoxyuridine.
Nucleosides, nucleotides & nucleic acids 2000;19(3):691-702.
2000: Schinazi R F; Hurwitz S J; Liberman I; Juodawlkis A S; Tharnish P; Shi J; Liotta D C; Coderre J A; Olson J
Treatment of isografted 9L rat brain tumors with beta-5-o-carboranyl-2'-deoxyuridine neutron capture therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(2):725-30.
2000: Martin L T; Cretton-Scott E; Placidi L; Faraj A; Loi A G; Schinazi R F; McClure H M; Gosselin G; Imbach J L; Sommadossi J P
In vitro and in vivo metabolism and pharmacokinetics of bis [(t-butyl)-S-acyl-2-thioethyl]-beta-L-2',3'-dideoxy-5-fluorocytidine monophosphate.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):481-99.
2000: Pierra C; Olgen S; Cavalcanti S C; Cheng Y C; Schinazi R F; Chu C K
Synthesis and antiviral activities of enantiomeric 1-[2-(hydroxymethyl) cyclopropyl] methyl nucleosides.
Nucleosides, nucleotides & nucleic acids 2000;19(1-2):253-68.
2000: Stuyver L; De Gendt S; Van Geyt C; Zoulim F; Fried M; Schinazi R F; Rossau R
A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness.
The Journal of general virology 2000;81(Pt 1):67-74.
2000: Gustafson E A; Schinazi R F; Fingeroth J D
Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phosphorylates zidovudine but not ganciclovir.
Journal of virology 2000;74(2):684-92.
2000: Klarmann G J; Smith R A; Schinazi R F; North T W; Preston B D
Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site.
The Journal of biological chemistry 2000;275(1):359-66.
2000: Ashour O M; Naguib F N; Goudgaon N M; Schinazi R F; el Kouni M H
Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2',3',5'-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy.
Cancer chemotherapy and pharmacology 2000;46(3):235-40.
2000: Ashour O M; Al Safarjalani O N; Naguib F N; Goudgaon N M; Schinazi R F; el Kouni M H
Modulation of plasma uridine concentration by 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase: relevance to chemotherapy.
Cancer chemotherapy and pharmacology 2000;45(5):351-61.
1999: Mourier N S; Eleuteri A; Hurwitz S J; Tharnish P M; Schinazi R F
Enantioselective synthesis and biological evaluation of 5-o-carboranyl pyrimidine nucleosides.
Bioorganic & medicinal chemistry 1999;7(12):2759-66.
1999: Chen H; Schinazi R F; Rajagopalan P; Gao Z; Chu C K; McClure H M; Boudinot F D
Pharmacokinetics of (-)-beta-D-dioxolane guanine and prodrug (-)-beta-D-2,6-diaminopurine dioxolane in rats and monkeys.
AIDS research and human retroviruses 1999;15(18):1625-30.
1999: Cavalcanti S C; Xiang Y; Newton M G; Schinazi R F; Cheng Y C; Chu C K
Synthesis of 2',3'-dideoxy-2'-fluoro-L-threo-pentofuranosyl nucleosides as potential antiviral agents.
Nucleosides & nucleotides 1999;18(10):2233-52.
1999: Feng J Y; Shi J; Schinazi R F; Anderson K S
Mechanistic studies show that (-)-FTC-TP is a better inhibitor of HIV-1 reverse transcriptase than 3TC-TP.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(12):1511-7.
1999: Wang P; Gullen B; Newton M G; Cheng Y C; Schinazi R F; Chu C K
Asymmetric synthesis and antiviral activities of L-carbocyclic 2', 3'-didehydro-2',3'-dideoxy and 2',3'-dideoxy nucleosides.
Journal of medicinal chemistry 1999;42(17):3390-9.
1999: Smith R A; Klarmann G J; Stray K M; von Schwedler U K; Schinazi R F; Preston B D; North T W
A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidine.
Antimicrobial agents and chemotherapy 1999;43(8):2077-80.
1999: Schinazi R F; Ilan E; Black P L; Yao X; Dagan S
Cell-based and animal models for hepatitis B and C viruses.
Antiviral chemistry & chemotherapy 1999;10(3):99-114.
1999: Loi A G; Faraj A; Pierra C; Gosselin G; Imbach J L; Locarnini S A; Groman E V; Schinazi R F; Sommadossi J P
Comparison of anti-HBV activity of beta-D- and beta-L-DDA-5'monophosphate prodrugs and effectiveness in combination with lamivudine.
Nucleosides & nucleotides 1999;18(4-5):1005-6.
1999: Faraj A; Placidi L; Perigaud C; Cretton-Scott E; Gosselin G; Martin L T; Pierra C; Schinazi R F; Imbach J L; Sommadossi J P
Intracellular metabolism of beta-L-ddAMP-bis(tbutylSATE), a potent inhibitor of hepatitis B virus replication.
Nucleosides & nucleotides 1999;18(4-5):987-8.
1999: Lee K; Choi Y; Hong J H; Schinazi R F; Chu C K
New classes of fluorinated L-nucleosides; synthesis and antiviral activity.
Nucleosides & nucleotides 1999;18(4-5):537-40.
1999: Lee K; Choi Y; Gullen E; Schlueter-Wirtz S; Schinazi R F; Cheng Y C; Chu C K
Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2', 3'-unsaturated L-nucleosides.
Journal of medicinal chemistry 1999;42(7):1320-8.
1999: Martin L T; Cretton-Scott E; Schinazi R F; Zhou X J; McClure H M; Mathe C; Gosselin G; Imbach J L; Sommadossi J P
Pharmacokinetics of beta-L-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1999;43(4):920-4.
1999: Hart C E; Lennox J L; Pratt-Palmore M; Wright T C; Schinazi R F; Evans-Strickfaden T; Bush T J; Schnell C; Conley L J; Clancy K A; Ellerbrock T V
Correlation of human immunodeficiency virus type 1 RNA levels in blood and the female genital tract.
The Journal of infectious diseases 1999;179(4):871-82.
1999: Shi J; McAtee J J; Schlueter Wirtz S; Tharnish P; Juodawlkis A; Liotta D C; Schinazi R F
Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
Journal of medicinal chemistry 1999;42(5):859-67.
1999: Ma L; Hurwitz S J; Shi J; Mcatee J J; Liotta D C; McClure H M; Schinazi R F
Pharmacokinetics of the antiviral agent beta-D-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1999;43(2):381-4.
1999: García Lerma J; Schinazi R F; Juodawlkis A S; Soriano V; Lin Y; Tatti K; Rimland D; Folks T M; Heneine W
A rapid non-culture-based assay for clinical monitoring of phenotypic resistance of human immunodeficiency virus type 1 to lamivudine (3TC).
Antimicrobial agents and chemotherapy 1999;43(2):264-70.
1999: Lin P F; González C J; Griffith B; Friedland G; Calvez V; Ferchal F; Schinazi R F; Shepp D H; Ashraf A B; Wainberg M A; Soriano V; Mellors J W; Colonno R J
Stavudine resistance: an update on susceptibility following prolonged therapy.
Antiviral therapy 1999;4(1):21-8.
1998: Hurwitz S J; Tennant B C; Korba B E; Gerin J L; Schinazi R F
Pharmacodynamics of (-)-beta-2',3'-dideoxy-3'-thiacytidine in chronically virus-infected woodchucks compared to its pharmacodynamics in humans.
Antimicrobial agents and chemotherapy 1998;42(11):2804-9.
1998: Wang P; Schinazi R F; Chu C K
Asymmetric synthesis and anti-HIV activity of L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine.
Bioorganic & medicinal chemistry letters 1998;8(13):1585-8.
1998: Graciet J C; Shi J; Schinazi R F
Synthesis and biological properties of the four optical isomers of 5-o-carboranyl-2',3'-didehydro-2',3'-dideoxyuridine.
Nucleosides & nucleotides 1998;17(4):711-27.
1998: Smith R A; Remington K M; Preston B D; Schinazi R F; North T W
A novel point mutation at position 156 of reverse transcriptase from feline immunodeficiency virus confers resistance to the combination of (-)-beta-2',3'-dideoxy-3'-thiacytidine and 3'-azido-3'-deoxythymidine.
Journal of virology 1998;72(3):2335-40.
1998: You X; Schinazi R F; Arrowood M J; Lejkowski M; Juodawlkis A S; Mead J R
In-vitro activities of paromomycin and lasalocid evaluated in combination against Cryptosporidium parvum.
The Journal of antimicrobial chemotherapy 1998;41(2):293-6.
1998: Schinazi R F; Lesnikowski Z J
Boron containing oligonucleotides.
Nucleosides & nucleotides 1998;17(1-3):635-47.
1998: Pillay D; Schinazi R F
Antiviral drug resistance: from the laboratory to the patient.
Antiviral therapy 1998;3(4):237.
1997: Black J B; Burns D A; Goldsmith C S; Feorino P M; Kite-Powell K; Schinazi R F; Krug P W; Pellett P E
Biologic properties of human herpesvirus 7 strain SB.
Virus research 1997;52(1):25-41.
1997: Pan-Zhou X R; Cretton-Scott E; Zhou X J; Xie M Y; Rahmani R; Schinazi R F; Duchin K; Sommadossi J P
Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes.
Antimicrobial agents and chemotherapy 1997;41(11):2502-10.
1997: Kotra L P; Xiang Y; Newton M G; Schinazi R F; Cheng Y C; Chu C K
Structure-activity relationships of 2'-deoxy-2',2'-difluoro-L-erythro-pentofuranosyl nucleosides.
Journal of medicinal chemistry 1997;40(22):3635-44.
1997: McIntee E J; Remmel R P; Schinazi R F; Abraham T W; Wagner C R
Probing the mechanism of action and decomposition of amino acid phosphomonoester amidates of antiviral nucleoside prodrugs.
Journal of medicinal chemistry 1997;40(21):3323-31.
1997: Lin Y M; Anderson H; Flavin M T; Pai Y H; Mata-Greenwood E; Pengsuparp T; Pezzuto J M; Schinazi R F; Hughes S H; Chen F C
In vitro anti-HIV activity of biflavonoids isolated from Rhus succedanea and Garcinia multiflora.
Journal of natural products 1997;60(9):884-8.
1997: Du J; Surzhykov S; Lin J S; Newton M G; Cheng Y C; Schinazi R F; Chu C K
Synthesis, anti-human immunodeficiency virus and anti-hepatitis B virus activities of novel oxaselenolane nucleosides.
Journal of medicinal chemistry 1997;40(19):2991-3.
1997: Manouilov K K; Manouilova L S; Boudinot F D; Schinazi R F; Chu C K
Biotransformation and pharmacokinetics of prodrug 9-(beta-D-1,3-dioxolan-4-yl)-2-aminopurine and its antiviral metabolite 9-(beta-D-1,3-dioxolan-4-yl)guanine in mice.
Antiviral research 1997;35(3):187-93.
1997: Manouilov K K; Xu Z S; Boudinot F D; Schinazi R F; Chu C K
Lymphatic targeting of anti-HIV nucleosides: distribution of 2',3'-dideoxyinosine after intravenous and oral administration of dipalmitoylphosphatidyl prodrug in mice.
Antiviral research 1997;34(3):91-9.
1997: Chen H; Manouilov K K; Chu C K; Schinazi R F; McClure H M; Boudinot F D
High-performance liquid chromatographic determination of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane, and their metabolite (-)-beta-D-dioxolane guanine in monkey serum, urine and cerebrospinal fluid.
Journal of chromatography. B, Biomedical sciences and applications 1997;691(2):425-32.
1997: Barnard D L; Hill C L; Gage T; Matheson J E; Huffman J H; Sidwell R W; Otto M I; Schinazi R F
Potent inhibition of respiratory syncytial virus by polyoxometalates of several structural classes.
Antiviral research 1997;34(1):27-37.
1997: Smith R A; Remington K M; Lloyd R M; Schinazi R F; North T W
A novel Met-to-Thr mutation in the YMDD motif of reverse transcriptase from feline immunodeficiency virus confers resistance to oxathiolane nucleosides.
Journal of virology 1997;71(3):2357-62.
1997: Stuyver L; Wyseur A; Rombout A; Louwagie J; Scarcez T; Verhofstede C; Rimland D; Schinazi R F; Rossau R
Line probe assay for rapid detection of drug-selected mutations in the human immunodeficiency virus type 1 reverse transcriptase gene.
Antimicrobial agents and chemotherapy 1997;41(2):284-91.
1997: Martin L T; Faraj A; Schinazi R F; Gosselin G; Mathe C; Imbach J L; Sommadossi J P
Effect of stereoisomerism on the cellular pharmacology of beta-enantiomers of cytidine analogs in Hep-G2 cells.
Biochemical pharmacology 1997;53(1):75-87.
1996: Kotra L P; Manouilov K K; Cretton-Scott E; Sommadossi J P; Boudinot F D; Schinazi R F; Chu C K
Synthesis, biotransformation, and pharmacokinetic studies of 9-(beta-D-arabinofuranosyl)-6-azidopurine: a prodrug for ara-A designed to utilize the azide reduction pathway.
Journal of medicinal chemistry 1996;39(26):5202-7.
1996: Cui L; Schinazi R F; Gosselin G; Imbach J L; Chu C K; Rando R F; Revankar G R; Sommadossi J P
Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity.
Biochemical pharmacology 1996;52(10):1577-84.
1996: Koudriakova T; Manouilov K K; Shanmuganathan K; Kotra L P; Boudinot F D; Cretton-Scott E; Sommadossi J P; Schinazi R F; Chu C K
In vitro and in vivo evaluation of 6-azido-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosylpurine and N6-methyl-2',3'-dideoxy-2'-fluoro-beta-D-arabinofuranosyladenine as prodrugs of the anti-HIV nucleosides 2'-F-ara-ddA and 2'-F-ara-ddI.
Journal of medicinal chemistry 1996;39(23):4676-81.
1996: Chen H; Boudinot F D; Chu C K; Mcclure H M; Schinazi R F
Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1996;40(10):2332-6.
1996: Rajagopalan P; Wudl F; Schinazi R F; Boudinot F D
Pharmacokinetics of a water-soluble fullerene in rats.
Antimicrobial agents and chemotherapy 1996;40(10):2262-5.
1996: You X; Arrowood M J; Lejkowski M; Xie L; Schinazi R F; Mead J R
In vitro evaluation of anticryptosporidial agents using MDCK cell culture and chemiluminescence immunoassay.
The Journal of eukaryotic microbiology 1996;43(5):87S.
1996: Mead J R; Bonafonte M T; Arrowood M J; Schinazi R F
In vitro expression of mRNA coding for a Cryptosporidium parvum oocyst wall protein.
The Journal of eukaryotic microbiology 1996;43(5):84S-85S.
1996: Bonafonte M T; Lloyd R M; Garmon K D; You X; Arrowood M J; Schinazi R F; Mead J R
Cloning and expression of sporozoite and oocyst Cryptosporidium parvum recombinant proteins.
The Journal of eukaryotic microbiology 1996;43(5):83S.
1996: el Kouni M H; Naguib F N; Panzica R P; Otter B A; Chu S H; Gosselin G; Chu C K; Schinazi R F; Shealy Y F; Goudgaon N; Ozerov A A; Ueda T; Iltzsch M H
Effects of modifications in the pentose moiety and conformational changes on the binding of nucleoside ligands to uridine phosphorylase from Toxoplasma gondii.
Biochemical pharmacology 1996;51(12):1687-700.
1996: Cherrington J M; Fuller M D; Mulato A S; Allen S J; Kunder S C; Ussery M A; Lesnikowski Z; Schinazi R F; Sommadossi J P; Chen M S
Comparative kinetic analyses of interaction of inhibitors with Rauscher murine leukemia virus and human immunodeficiency virus reverse transcriptases.
Antimicrobial agents and chemotherapy 1996;40(5):1270-3.
1996: Lesnikowski Z J; Fulcrand G; Lloyd R M; Juodawlkis A; Schinazi R F
Carboranyl oligonucleotides. 3. Biochemical properties of oligonucleotides containing 5-(o-carboranyl-1-yl)-2'-deoxyuridine.
Biochemistry 1996;35(18):5741-6.
1996: Mazumder A; Neamati N; Sommadossi J P; Gosselin G; Schinazi R F; Imbach J L; Pommier Y
Effects of nucleotide analogues on human immunodeficiency virus type 1 integrase.
Molecular pharmacology 1996;49(4):621-8.
1996: You X; Arrowood M J; Lejkowski M; Xie L; Schinazi R F; Mead J R
A chemiluminescence immunoassay for evaluation of Cryptosporidium parvum growth in vitro.
FEMS microbiology letters 1996;136(3):251-6.
1996: Rajagopalan P; Boudinot F D; Chu C K; Tennant B C; Baldwin B H; Schinazi R F
Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks.
Antimicrobial agents and chemotherapy 1996;40(3):642-5.
1996: Faraj A; Schinazi R F; Xie M Y; Gosselin G; Perigaud C; Imbach J L; Sommadossi J P
Selective protection of toxicity of 2',3'-dideoxypyrimidine nucleoside analogs by beta-D-uridine in human granulocyte-macrophage progenitor cells.
Antiviral research 1996;29(2-3):261-7.
1995: Schinazi R F; Yao X
Hydrocephalus induction in mice infected with herpes simplex virus type 2 after antiviral treatment.
Antiviral research 1995;28(4):291-302.
1995: Rajagopalan P; Gao Z; Chu C K; Schinazi R F; McClure H M; Boudinot F D
High-performance liquid chromatographic determination of (-)-beta-D-2,6-diaminopurine dioxolane and its metabolite, dioxolane guanosine, using ultraviolet and on-line radiochemical detection.
Journal of chromatography. B, Biomedical applications 1995;672(1):119-24.
1995: Xie H; Voronkov M; Liotta D C; Korba B A; Schinazi R F; Richman D D; Hostetler K Y
Phosphatidyl-2',3'-dideoxy-3'-thiacytidine: synthesis and antiviral activity in hepatitis B-and HIV-1-infected cells.
Antiviral research 1995;28(2):113-20.
1995: Wengel J; Schinazi R F; Caruthers M H
Stereoselective synthesis, chemistry and antiviral evaluation of 1-(2,3-dideoxy-3-C-hydroxymethyl-beta-D-threo-pentofuranosyl)thymine derivatives.
Bioorganic & medicinal chemistry 1995;3(9):1223-9.
1995: Mellors J W; Bazmi H Z; Schinazi R F; Roy B M; Hsiou Y; Arnold E; Weir J; Mayers D L
Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolates.
Antimicrobial agents and chemotherapy 1995;39(5):1087-92.
1995: Ni L; Schinazi R F; Boudinot F D
Pharmacokinetics and toxicity of the human immunodeficiency virus inhibitor 1-ethoxymethyl-6-phenylselenenyl-5-ethyluracil in rodents.
Antiviral research 1995;27(1-2):39-47.
1995: Mead J R; You X; Pharr J E; Belenkaya Y; Arrowood M J; Fallon M T; Schinazi R F
Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis.
Antimicrobial agents and chemotherapy 1995;39(4):854-8.
1995: Cui L; Yoon S; Schinazi R F; Sommadossi J P
Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.
The Journal of clinical investigation 1995;95(2):555-63.
1994: Jarugula V R; Schinazi R F; Fulcrand G; el Kattan Y; Liotta D C; Boudinot F D
Pharmacokinetics of 5-carboranyl-2'-deoxyuridine in rats.
Journal of pharmaceutical sciences 1994;83(12):1697-9.
1994: Nguyen M H; Schinazi R F; Shi C; Goudgaon N M; McKenna P M; Mellors J W
Resistance of human immunodeficiency virus type 1 to acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidines.
Antimicrobial agents and chemotherapy 1994;38(10):2409-14.
1994: Faraj A; Agrofoglio L A; Wakefield J K; McPherson S; Morrow C D; Gosselin G; Mathe C; Imbach J L; Schinazi R F; Sommadossi J P
Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs.
Antimicrobial agents and chemotherapy 1994;38(10):2300-5.
1994: Belen'kii M S; Schinazi R F
Multiple drug effect analysis with confidence interval.
Antiviral research 1994;25(1):1-11.
1994: Schinazi R F; Gosselin G; Faraj A; Korba B E; Liotta D C; Chu C K; Mathé C; Imbach J L; Sommadossi J P
Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro.
Antimicrobial agents and chemotherapy 1994;38(9):2172-4.
1994: Mead J R; Lloyd R M; You X; Tucker-Burden C; Arrowood M J; Schinazi R F
Isolation and partial characterization of Cryptosporidium sporozoite and oocyst wall recombinant proteins.
The Journal of eukaryotic microbiology 1994;41(5):51S.
1994: Fulcrand-el Kattan G; Goudgaon N M; Ilksoy N; Huang J T; Watanabe K A; Sommadossi J P; Schinazi R F
Synthesis and biological properties of 5-o-carboranyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil.
Journal of medicinal chemistry 1994;37(16):2583-8.
1994: Gosselin G; Schinazi R F; Sommadossi J P; Mathé C; Bergogne M C; Aubertin A M; Kirn A; Imbach J L
Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro.
Antimicrobial agents and chemotherapy 1994;38(6):1292-7.
1994: Mead J R; Ilksoy N; You X; Belenkaya Y; Arrowood M J; Fallon M T; Schinazi R F
Infection dynamics and clinical features of cryptosporidiosis in SCID mice.
Infection and immunity 1994;62(5):1691-5.
1994: Schinazi R F; Goudgaon N M; Fulcrand G; el Kattan Y; Lesnikowski Z; Ullas G; Moravek J; Liotta D C
Cellular pharmacology and biological activity of 5-carboranyl-2'-deoxyuridine.
International journal of radiation oncology, biology, physics 1994;28(5):1113-20.
1994: Shanmuganathan K; Koudriakova T; Nampalli S; Du J; Gallo J M; Schinazi R F; Chu C K
Enhanced brain delivery of an anti-HIV nucleoside 2'-F-ara-ddI by xanthine oxidase mediated biotransformation.
Journal of medicinal chemistry 1994;37(6):821-7.
1994: Kim G S; Judd D A; Hill C L; Schinazi R F
Synthesis, characterization, and biological activity of a new potent class of anti-HIV agents, the peroxoniobium-substituted heteropolytungstates.
Journal of medicinal chemistry 1994;37(6):816-20.
1994: Schinazi R F; Lloyd R M; Ramanathan C S; Taylor E W
Antiviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase occur in specific RNA structural regions.
Antimicrobial agents and chemotherapy 1994;38(2):268-74.
1994: Abobo C V; Ni L; Schinazi R F; Liotta D C; Boudinot F D
Pharmacokinetics of 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rats.
Journal of pharmaceutical sciences 1994;83(1):96-9.
1994: Gosselin G; Mathé C; Bergogne M C; Aubertin A M; Kirn A; Schinazi R F; Sommadossi J P; Imbach J L
Enantiomeric 2',3'-dideoxycytidine derivatives are potent human immunodeficiency virus inhibitors in cell cultures.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1994;317(1):85-9.
1994: Abghari S Z; Stulting R D; Zhu Z; Schinazi R F; Kaufman H E
Effect of genetically determined host factors on the efficacy of vidarabine, acyclovir and 5-trifluorothymidine in herpes simplex virus type 1 infection.
Ophthalmic research 1994;26(2):95-104.
1993: Goudgaon N M; Naguib F N; el Kouni M H; Schinazi R F
Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase.
Journal of medicinal chemistry 1993;36(26):4250-4.
1993: Mathez D; Schinazi R F; Liotta D C; Leibowitch J
Infectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro.
Antimicrobial agents and chemotherapy 1993;37(10):2206-11.
1993: Jeong L S; Schinazi R F; Beach J W; Kim H O; Shanmuganathan K; Nampalli S; Chun M W; Chung W K; Choi B G; Chu C K
Structure-activity relationships of beta-D-(2S,5R)- and alpha-D-(2S,5S)-1,3-oxathiolanyl nucleosides as potential anti-HIV agents.
Journal of medicinal chemistry 1993;36(18):2627-38.
1993: Boudinot F D; Schinazi R F; Doshi K J; McClure H M; Chu C K
Pharmacokinetics and metabolism of 3'-azido-2',3'-dideoxy-5-methylcytidine in rhesus monkeys.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(5):855-60.
1993: Lin X; Dashti A; Schinazi R F; Tang J
Intracellular diversion of glycoprotein GP160 of human immunodeficiency virus to lysosomes as a strategy of AIDS gene therapy.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(11):1070-80.
1993: Schinazi R F; Sijbesma R; Srdanov G; Hill C L; Wudl F
Synthesis and virucidal activity of a water-soluble, configurationally stable, derivatized C60 fullerene.
Antimicrobial agents and chemotherapy 1993;37(8):1707-10.
1993: Lin T S; Schinazi R F; Zhu J; Birks E; Carbone R; Si Y; Wu K; Huang L; Prusoff W H
Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol.
Biochemical pharmacology 1993;46(2):251-5.
1993: Shewach D S; Liotta D C; Schinazi R F
Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2'-deoxycytidine kinase.
Biochemical pharmacology 1993;45(7):1540-3.
1993: Schinazi R F; Lloyd R M; Nguyen M H; Cannon D L; McMillan A; Ilksoy N; Chu C K; Liotta D C; Bazmi H Z; Mellors J W
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides.
Antimicrobial agents and chemotherapy 1993;37(4):875-81.
1993: Kim H O; Schinazi R F; Shanmuganathan K; Jeong L S; Beach J W; Nampalli S; Cannon D L; Chu C K
L-beta-(2S,4S)- and L-alpha-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships.
Journal of medicinal chemistry 1993;36(5):519-28.
1993: Schinazi R F; Del Bene V E
Non-HIV-1 CD4+ lymphocyte depletion in a patient with an acquired immunodeficiency syndrome of unknown etiology.
AIDS (London, England) 1993;7(2):284-5.
1993: Jeong L S; Schinazi R F; Beach J W; Kim H O; Nampalli S; Shanmuganathan K; Alves A J; McMillan A; Chu C K; Mathis R
Asymmetric synthesis and biological evaluation of beta-L-(2R,5S)- and alpha-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents.
Journal of medicinal chemistry 1993;36(2):181-95.
1993: Kim H O; Schinazi R F; Nampalli S; Shanmuganathan K; Cannon D L; Alves A J; Jeong L S; Beach J W; Chu C K
1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes.
Journal of medicinal chemistry 1993;36(1):30-7.
1992: Schinazi R F; Boudinot F D; Ibrahim S S; Manning C; McClure H M; Liotta D C
Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1992;36(11):2432-8.
1992: Sommadossi J P; Schinazi R F; Chu C K; Xie M Y
Comparison of cytotoxicity of the (-)- and (+)-enantiomer of 2',3'-dideoxy-3'-thiacytidine in normal human bone marrow progenitor cells.
Biochemical pharmacology 1992;44(10):1921-5.
1992: Schinazi R F; McMillan A; Cannon D; Mathis R; Lloyd R M; Peck A; Sommadossi J P; St Clair M; Wilson J; Furman P A
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine.
Antimicrobial agents and chemotherapy 1992;36(11):2423-31.
1992: Cretton E M; Xie M Y; Goudgaon N M; Schinazi R F; Chu C K; Sommadossi J P
Catabolic disposition of 3'-azido-2',3'-dideoxyuridine in hepatocytes with evidence of azido reduction being a general catabolic pathway of 3'-azido-2',3'-dideoxynucleosides.
Biochemical pharmacology 1992;44(5):973-80.
1992: Taraporewala I B; Cessac J W; Chanh T C; Delgado A V; Schinazi R F
HIV-1 neutralization and tumor cell proliferation inhibition in vitro by simplified analogues of pyrido[4,3,2-mn]thiazolo[5,4-b]acridine marine alkaloids.
Journal of medicinal chemistry 1992;35(15):2744-52.
1992: Schinazi R F; Peck A; Sommadossi J P
Substrate specificity of Escherichia coli thymidine phosphorylase for pyrimidine nucleosides with anti-human immunodeficiency virus activity.
Biochemical pharmacology 1992;44(2):199-204.
1992: Chang C N; Doong S L; Zhou J H; Beach J W; Jeong L S; Chu C K; Tsai C H; Cheng Y C; Liotta D; Schinazi R
Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.
The Journal of biological chemistry 1992;267(20):13938-42.
1992: Schinazi R F; Mead J R; Feorino P M
Insights into HIV chemotherapy.
AIDS research and human retroviruses 1992;8(6):963-90.
1992: Kim H O; Ahn S K; Alves A J; Beach J W; Jeong L S; Choi B G; Van Roey P; Schinazi R F; Chu C K
Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.
Journal of medicinal chemistry 1992;35(11):1987-95.
1992: Weeks M S; Hill C L; Schinazi R F
Synthesis, characterization, and anti-human immunodeficiency virus activity of water-soluble salts of polyoxotungstate anions with covalently attached organic groups.
Journal of medicinal chemistry 1992;35(7):1216-21.
1992: Schinazi R F; Chu C K; Peck A; McMillan A; Mathis R; Cannon D; Jeong L S; Beach J W; Choi W B; Yeola S
Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.
Antimicrobial agents and chemotherapy 1992;36(3):672-6.
1992: Bardos T J; Schinazi R F; Ling K H; Heider A R
Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1992;36(1):108-14.
1991: Goudgaon N M; Schinazi R F
Activity of acyclic 6-(phenylselenenyl)pyrimidine nucleosides against human immunodeficiency viruses in primary lymphocytes.
Journal of medicinal chemistry 1991;34(11):3305-9.
1991: Doong S L; Tsai C H; Schinazi R F; Liotta D C; Cheng Y C
Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8495-9.
1991: Strekowski L; Mokrosz J L; Honkan V A; Czarny A; Cegla M T; Wydra R L; Patterson S E; Schinazi R F
Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-HIV-1 agents.
Journal of medicinal chemistry 1991;34(5):1739-46.
1991: Cretton E M; Schinazi R F; McClure H M; Anderson D C; Sommadossi J P
Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys.
Antimicrobial agents and chemotherapy 1991;35(5):801-7.
1991: Boudinot F D; Smith S G; Funderburg E D; Schinazi R F
Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rats.
Antimicrobial agents and chemotherapy 1991;35(4):747-9.
1991: Cretton E M; Xie M Y; Bevan R J; Goudgaon N M; Schinazi R F; Sommadossi J P
Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells.
Molecular pharmacology 1991;39(2):258-66.
1990: Zhu Z; Schinazi R F; Chu C K; Williams G J; Colby C B; Sommadossi J P
Cellular metabolism of 3'-azido-2',3'-dideoxyuridine with formation of 5'-O-diphosphohexose derivatives by previously unrecognized metabolic pathways for 2'-deoxyuridine analogs.
Molecular pharmacology 1990;38(6):929-38.
1990: Hill C L; Weeks M S; Schinazi R F
Anti-HIV-1 activity, toxicity, and stability studies of representative structural families of polyoxometalates.
Journal of medicinal chemistry 1990;33(10):2767-72.
1990: Hirota K; Hosono H; Kitade Y; Maki Y; Chu C K; Schinazi R F; Nakane H; Ono K
Synthesis and anti-human immunodeficiency virus (HIV-1) activity of 3'-deoxy-3'-(triazol-1-yl)thymidines and 2',3'-dideoxy-3'-(triazol-1-yl)uridines and inhibition of reverse transcriptase by their 5'-triphosphates.
Chemical & pharmaceutical bulletin 1990;38(9):2597-601.
1990: Chu C K; Bhadti V S; Doshi K J; Etse J T; Gallo J M; Boudinot F D; Schinazi R F
Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine.
Journal of medicinal chemistry 1990;33(8):2188-92.
1990: Schinazi R F; Sommadossi J P; Saalmann V; Cannon D L; Xie M Y; Hart G C; Smith G A; Hahn E F
Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1990;34(6):1061-7.
1990: Chu C K; Ullas G V; Jeong L S; Ahn S K; Doboszewski B; Lin Z X; Beach J W; Schinazi R F
Synthesis and structure-activity relationships of 6-substituted 2',3'-dideoxypurine nucleosides as potential anti-human immunodeficiency virus agents.
Journal of medicinal chemistry 1990;33(6):1553-61.
1990: Schinazi R F; Boudinot F D; Doshi K J; McClure H M
Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys.
Antimicrobial agents and chemotherapy 1990;34(6):1214-9.
1990: Schinazi R F; Chu C K; Babu J R; Oswald B J; Saalmann V; Cannon D L; Eriksson B F; Nasr M
Anthraquinones as a new class of antiviral agents against human immunodeficiency virus.
Antiviral research 1990;13(5):265-72.
1990: Patel B A; Boudinot F D; Schinazi R F; Gallo J M; Chu C K
Comparative pharmacokinetics and interspecies scaling of 3'-azido-3'-deoxythymidine (AZT) in several mammalian species.
Journal of pharmacobio-dynamics 1990;13(3):206-11.
1990: Boudinot F D; Schinazi R F; Gallo J M; McClure H M; Anderson D C; Doshi K J; Kambhampathi P C; Chu C K
3'-Azido-2',3'-dideoxyuridine (AzddU): comparative pharmacokinetics with 3'-azido-3'-deoxythymidine (AZT) in monkeys.
AIDS research and human retroviruses 1990;6(2):219-28.
1990: McCaffrey R; Duff R; Bulger K; Spigelman Z; Flora K; Schinazi R; Chu C K
Terminal transferase as a therapeutic target in leukemia cells.
Progress in clinical and biological research 1990;352():409-16.
1990: McClure H M; Anderson D C; Ansari A A; Fultz P N; Klumpp S A; Schinazi R F
Nonhuman primate models for evaluation of AIDS therapy.
Annals of the New York Academy of Sciences 1990;616():287-98.
1990: Weinstein J N; Bunow B; Weislow O S; Schinazi R F; Wahl S M; Wahl L M; Szebeni J
Synergistic drug combinations in AIDS therapy. Dipyridamole/3'-azido-3'-deoxythymidine in particular and principles of analysis in general.
Annals of the New York Academy of Sciences 1990;616():367-84.
1990: Schinazi R F; Chu C K; Eriksson B F; Sommadossi J P; Doshi K J; Boudinot F D; Oswald B; McClure H M
Antiretroviral activity, biochemistry, and pharmacokinetics of 3'-azido-2',3'-dideoxy-5-methylcytidine.
Annals of the New York Academy of Sciences 1990;616():385-97.
1990: Van Roey P; Taylor E W; Chu C K; Schinazi R F
Correlation of molecular conformation and activity of reverse transcriptase inhibitors.
Annals of the New York Academy of Sciences 1990;616():29-40.
1989: Lin T S; Schinazi R; Griffith B P; August E M; Eriksson B F; Zheng D K; Huang L A; Prusoff W H
Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol.
Antimicrobial agents and chemotherapy 1989;33(12):2149-51.
1989: Doshi K J; Gallo J M; Boudinot F D; Schinazi R F; Chu C K
Comparative pharmacokinetics of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZddU) in mice.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(6):590-4.
1989: Eriksson B F; Chu C K; Schinazi R F
Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate.
Antimicrobial agents and chemotherapy 1989;33(10):1729-34.
1989: Van Roey P; Salerno J M; Chu C K; Schinazi R F
Correlation between preferred sugar ring conformation and activity of nucleoside analogues against human immunodeficiency virus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):3929-33.
1989: Eriksson B F; Schinazi R F
Combinations of 3'-azido-3'-deoxythymidine (zidovudine) and phosphonoformate (foscarnet) against human immunodeficiency virus type 1 and cytomegalovirus replication in vitro.
Antimicrobial agents and chemotherapy 1989;33(5):663-9.
1989: Chu C K; Schinazi R F; Ahn M K; Ullas G V; Gu Z P
Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells.
Journal of medicinal chemistry 1989;32(3):612-7.
1989: Scheiner P; Geer A; Bucknor A M; Imbach J L; Schinazi R F
Acyclic analogues of 3'-azido-3'-deoxythymidine as potential antiviral agents. Nucleoside synthesis by Michael addition.
Journal of medicinal chemistry 1989;32(1):73-6.
1989: Schinazi R F; Eriksson B F; Hughes S H
Comparison of inhibitory activities of various antiretroviral agents against particle-derived and recombinant human immunodeficiency virus type 1 reverse transcriptases.
Antimicrobial agents and chemotherapy 1989;33(1):115-7.
1988: Schinazi R F; Cannon D L; Arnold B H; Martino-Saltzman D
Combinations of isoprinosine and 3'-azido-3'-deoxythymidine in lymphocytes infected with human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy 1988;32(12):1784-7.
1988: Chu C K; Schinazi R F; Arnold B H; Cannon D L; Doboszewski B; Bhadti V B; Gu Z P
Comparative activity of 2',3'-saturated and unsaturated pyrimidine and purine nucleosides against human immunodeficiency virus type 1 in peripheral blood mononuclear cells.
Biochemical pharmacology 1988;37(19):3543-8.
1988: Sommadossi J P; Carlisle R; Schinazi R F; Zhou Z
Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity.
Antimicrobial agents and chemotherapy 1988;32(7):997-1001.
1988: Lin T S; Guo J Y; Schinazi R F; Chu C K; Xiang J N; Prusoff W H
Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV).
Journal of medicinal chemistry 1988;31(2):336-40.
1987: Lin T S; Schinazi R F; Prusoff W H
Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus.
Biochemical pharmacology 1987;36(17):2713-8.
1987: Mundy D C; Schinazi R F; Gerber A R; Nahmias A J; Randall H W
Human immunodeficiency virus isolated from amniotic fluid.
Lancet 1987;2(8556):459-60.
1987: Schinazi R F
Drug combinations for treatment of mice infected with acyclovir-resistant herpes simplex virus.
Antimicrobial agents and chemotherapy 1987;31(3):477-9.
1987: Lin T S; Schinazi R F; Chen M S; Kinney-Thomas E; Prusoff W H
Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro.
Biochemical pharmacology 1987;36(3):311-6.
1987: Harada K; Matulic-Adamic J; Price R W; Schinazi R F; Watanabe K A; Fox J J
Nucleosides. 139. Synthesis and anticytomegalovirus and antiherpes simplex virus activity of 5'-modified analogues of 2'-fluoroarabinosylpyrimidine nucleosides.
Journal of medicinal chemistry 1987;30(1):226-9.
1987: Huang J T; Schinazi R F; Gadler H; Price R W; Su T L; Watanabe K A
5-substituted 2'-fluoro-arabinonucleosides as potential antiviral agents.
Nucleic acids symposium series 1987;(18):261-4.
1986: Schinazi R F; del Bene V; Scott R T; Dudley-Thorpe J B
Characterization of acyclovir-resistant and -sensitive herpes simplex viruses isolated from a patient with an acquired immune deficiency.
The Journal of antimicrobial chemotherapy 1986;18 Suppl B():127-34.
1986: Schinazi R F; Chou T C; Scott R T; Yao X J; Nahmias A J
Delayed treatment with combinations of antiviral drugs in mice infected with herpes simplex virus and application of the median effect method of analysis.
Antimicrobial agents and chemotherapy 1986;30(3):491-8.
1986: Schinazi R F; Arbiser J; Lee J J; Kalman T I; Prusoff W H
Synthesis and biological activity of 5-phenylselenenyl-substituted pyrimidine nucleosides.
Journal of medicinal chemistry 1986;29(7):1293-5.
1986: Schinazi R F; Fox J J; Watanabe K A; Nahmias A J
Activities of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2.
Antimicrobial agents and chemotherapy 1986;29(1):77-84.
1986: Su T L; Watanabe K A; Schinazi R F; Fox J J
Nucleosides. 136. Synthesis and antiviral effects of several 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-alkyluracils. Some structure-activity relationships.
Journal of medicinal chemistry 1986;29(1):151-4.
1985: Schinazi R F; Scott R T; Peters J; Rice V; Nahmias A J
Antiviral activity of 5-ethyl-2'-deoxyuridine against herpes simplex viruses in cell culture, mice, and guinea pigs.
Antimicrobial agents and chemotherapy 1985;28(4):552-60.
1985: Perlman M E; Watanabe K A; Schinazi R F; Fox J J
Nucleosides. 133. Synthesis of 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosines and related pyrimidine nucleosides as potential antiviral agents.
Journal of medicinal chemistry 1985;28(6):741-8.
1984: Schat K A; Schinazi R F; Calnek B W
Cell-specific antiviral activity of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) against Marek's disease herpesvirus and turkey herpesvirus.
Antiviral research 1984;4(5):259-70.
1983: Schinazi R F; Peters J; Sokol M K; Nahmias A J
Therapeutic activities of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine and -thymine alone and in combination with acyclovir and vidarabine in mice infected intracerebrally with herpes simplex virus.
Antimicrobial agents and chemotherapy 1983;24(1):95-103.
1983: Schinazi R F; Prusoff W H
Antiviral agents.
Pediatric clinics of North America 1983;30(1):77-92.
1982: Harrison D H; Schinazi R F; Rubin B H
Crystal structure and anti herpes simplex virus activity of 2,2'-anhydro-1-beta-D-arabinofuranosylthymine.
Journal of medicinal chemistry 1982;25(12):1507-10.
1982: Cheng Y C; Schinazi R F; Dutschman G E; Tan R S; Grill S P
Virus-induced thymidine kinases as markers for typing herpes simplex viruses and for drug sensitivity assays.
Journal of virological methods 1982;5(3-4):209-17.
1982: Schinazi R F; Peters J; Williams C C; Chance D; Nahmias A J
Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in mice.
Antimicrobial agents and chemotherapy 1982;22(3):499-507.
1982: Schinazi R F; Nahmias A J
Different in vitro effects of dual combinations of anti-herpes simplex virus compounds.
The American journal of medicine 1982;73(1A):40-8.
1981: Schinazi R F; Prusoff W H
Antiviral drugs: modes of action and strategies for therapy.
Hospital practice (Office ed.) 1981;16(6):113-24.
1981: Stanwick T L; Schinazi R F; Campbell D E; Nahmias A J
Combined antiviral effect of interferon and acyclovir on herpes simplex virus types 1 and 2.
Antimicrobial agents and chemotherapy 1981;19(4):672-4.
1980: Shiau G T; Schinazi R F; Chen M S; Prusoff W H
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
Journal of medicinal chemistry 1980;23(2):127-33.
1979: Schinazi R F; Chen M S; Prusoff W H
Antiviral and antineoplastic activities of pyrimidine arabinosyl nucleosides and their 5'-amino derivatives.
Journal of medicinal chemistry 1979;22(10):1273-7.
1979: Prusoff W H; Chen M S; Fischer P H; Lin T S; Shiau G T; Schinazi R F; Walker J
Antiviral iodinated pyrimidine deoxyribonucleosides: 5-iodo-2'-deoxyuridine; 5-iodo-2'-deoxycytidine; 5-iodo-5'-amino-2',5'-dideoxyuridine.
Pharmacology & therapeutics 1979;7(1):1-34.
1979: Prusoff W H; Chen M S; Fischer P H; Lin T S; Shiau G T; Schinazi R F
Role of nucleosides in virus and cancer chemotherapy.
Advances in ophthalmology = Fortschritte der Augenheilkunde = Progrès en ophtalmologie 1979;38():3-16.
1978: Schinazi R F; Chen M S; Prusoff W H
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
Journal of medicinal chemistry 1978;21(11):1141-6.

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