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Michael Butterworth

Research Profile

Chemicals & Drugs

Physiology

Enzyme Activation

Disorders

B-Cell Chronic Lymphocytic Leukemia

Anatomy

Co-author Network

Publications

TOP 3
Shankar Varadarajan; Jun Wei; Michael Butterworth; David Dinsdale; Maurizio Pellecchia; Gerald M Cohen
Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis.
S Varadarajan; J Wei; E T W Bampton; Michael Butterworth; R E Caves; David Dinsdale; T W Gant; J Mitcheson; M Pellecchia; J L Smalley; K Tanaka; Gerald M Cohen
A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.
Maria Baou; Susan L Kohlhaas; Michael Butterworth; Meike Vogler; David Dinsdale; Renata Walewska; Aneela Majid; Eric Eldering; Martin J S Dyer; Gerald M Cohen
Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.

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All Publications

2013: Shankar Varadarajan; Jun Wei; Michael Butterworth; David Dinsdale; Maurizio Pellecchia; Gerald M Cohen
Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis.
Neoplasia (New York, N.Y.) 2013;15(5):568-78.
2012: S Varadarajan; J Wei; E T W Bampton; Michael Butterworth; R E Caves; David Dinsdale; T W Gant; J Mitcheson; M Pellecchia; J L Smalley; K Tanaka; Gerald M Cohen
A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.
Cell death and differentiation 2012;19(12):1896-907.
2010: Maria Baou; Susan L Kohlhaas; Michael Butterworth; Meike Vogler; David Dinsdale; Renata Walewska; Aneela Majid; Eric Eldering; Martin J S Dyer; Gerald M Cohen
Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.
Haematologica 2010;95(9):1510-8.
2009: Michelle A Hughes; Nicholas Harper; Michael Butterworth; Kelvin Cain; Gerald M Cohen; Marion MacFarlane
Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.
Molecular cell 2009;35(3):265-79.
2009: Meike Vogler; Michael Butterworth; Aneela Majid; Renata Walewska; Xiao-Ming Sun; Martin J S Dyer; Gerald M Cohen
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia.
Blood 2009;113(18):4403-13.
2008: M Vogler; David Dinsdale; Xiao-Ming Sun; Kenneth W Young; Michael Butterworth; Pierluigi Nicotera; Martin J S Dyer; Gerald M Cohen
A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells.
Cell death and differentiation 2008;15(5):820-30.
2007: Alison J Faragher; Xiao-Ming Sun; Michael Butterworth; Nicholas Harper; Mike Mulheran; Sandrine Ruchaud; William C Earnshaw; Gerald M Cohen
Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase.
Molecular biology of the cell 2007;18(4):1337-47.
2004: Donald J L Jones; John H Lamb; Richard D Verschoyle; Lynne M Howells; Michael Butterworth; Chang Kee Lim; D Ferry; Peter B Farmer; Andreas J Gescher
Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity.
British journal of cancer 2004;91(6):1213-9.
2004: Xiao-Ming Sun; Michael Butterworth; Marion MacFarlane; Wolfgang Dubiel; Aaron Ciechanover; Gerald M Cohen
Caspase activation inhibits proteasome function during apoptosis.
Molecular cell 2004;14(1):81-93.
2002: Shawn B Bratton; J Lewis; Michael Butterworth; Colin S Duckett; Gerald M Cohen
XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis.
Cell death and differentiation 2002;9(9):881-92.
2002: Xiao-Ming Sun; Shawn B Bratton; Michael Butterworth; Marion MacFarlane; Gerald M Cohen
Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein.
The Journal of biological chemistry 2002;277(13):11345-51.
2001: Shawn B Bratton; G Walker; S M Srinivasula; Xiao-Ming Sun; Michael Butterworth; E S Alnemri; Gerald M Cohen
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.
The EMBO journal 2001;20(5):998-1009.