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David W. Wilson

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Surface Plasmon Resonance

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Thermodynamics

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Co-Publications
Name
62
Boykin, David
55
Tanious, Farial
26
Bailly, Christian
25
Strekowski, Lucjan
23
Kumar, Arvind
19
Neidle, Stephen
19
Nguyen, Binh
17
Brun, Reto
15
Tidwell, Richard
14
Lee, Moses
13
Ismail, Mohamed
13
Wenzler, Tanja
10
Hartley, John
9
Hall, James Edwin
9
Arafa, Reem

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Publications

TOP 3
Hu Laixing; Arafa Reem K; Ismail Mohamed A; Patel Alpa; Munde Manoj; Wilson W David; Wenzler Tanja; Brun Reto; Boykin David W
Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
Tevis Denise S; Kumar Arvind; Stephens Chad E; Boykin David W; Wilson W David
Large, sequence-dependent effects on DNA conformation by minor groove binding compounds.
Athri Prashanth; Wilson W David
Molecular dynamics of water-mediated interactions of a linear benzimidazole-biphenyl diamidine with the DNA minor groove.

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All Publications

2009: Hu Laixing; Arafa Reem K; Ismail Mohamed A; Patel Alpa; Munde Manoj; Wilson W David; Wenzler Tanja; Brun Reto; Boykin David W
Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.
Bioorganic & medicinal chemistry 2009;17(18):6651-8.
2009: Tevis Denise S; Kumar Arvind; Stephens Chad E; Boykin David W; Wilson W David
Large, sequence-dependent effects on DNA conformation by minor groove binding compounds.
Nucleic acids research 2009;37(16):5550-8.
2009: Athri Prashanth; Wilson W David
Molecular dynamics of water-mediated interactions of a linear benzimidazole-biphenyl diamidine with the DNA minor groove.
Journal of the American Chemical Society 2009;131(22):7618-25.
2009: Westrate Laura; Mackay Hilary; Brown Toni; Nguyen Binh; Kluza Jerome; Wilson W David; Lee Moses; Hartley John A
Effects of the N-terminal acylamido group of imidazole- and pyrrole-containing polyamides on DNA sequence specificity and binding affinity.
Biochemistry 2009;48(24):5679-88.
2009: Glass LaTeca S; Nguyen Binh; Goodwin Kristie D; Dardonville Christophe; Wilson W David; Long Eric C; Georgiadis Millie M
Crystal structure of a trypanocidal 4,4'-bis(imidazolinylamino)diphenylamine bound to DNA.
Biochemistry 2009;48(25):5943-52.
2009: Lajiness Jamie; Sielaff Alan; Mackay Hilary; Brown Toni; Kluza Jerome; Nguyen Binh; Wilson W David; Lee Moses; Hartley John A
Polyamide curvature and DNA sequence selective recognition: use of 4-aminobenzamide to adjust curvature.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2009;5(3):216-26.
2009: Rahimian Maryam; Kumar Arvind; Say Martial; Bakunov Stanislav A; Boykin David W; Tidwell Richard R; Wilson W David
Minor groove binding compounds that jump a gc base pair and bind to adjacent AT base pair sites.
Biochemistry 2009;48(7):1573-83.
2009: Nguyen Binh; Neidle Stephen; Wilson W David
A role for water molecules in DNA-ligand minor groove recognition.
Accounts of chemical research 2009;42(1):11-21.
2008: Drewe William C; Nanjunda Rupesh; Gunaratnam Mekala; Beltran Monica; Parkinson Gary N; Reszka Anthony P; Wilson W David; Neidle Stephen
Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs.
Journal of medicinal chemistry 2008;51(24):7751-67.
2008: Arafa Reem K; Ismail Mohamed A; Munde Manoj; Wilson W David; Wenzler Tanja; Brun Reto; Boykin David W
Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.
European journal of medicinal chemistry 2008;43(12):2901-8.
2008: Mackay Hilary; Brown Toni; Uthe Peter B; Westrate Laura; Sielaff Alan; Jones Justin; Lajiness James P; Kluza Jerome; O'Hare Caroline; Nguyen Binh; Davis Zach; Bruce Chrystal; Wilson W David; Hartley John A; Lee Moses
Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies.
Bioorganic & medicinal chemistry 2008;16(20):9145-53.
2008: Liu Yang; Collar Catharine J; Kumar Arvind; Stephens Chad E; Boykin David W; Wilson W David
Heterocyclic diamidine interactions at AT base pairs in the DNA minor groove: effects of heterocycle differences, DNA AT sequence and length.
The journal of physical chemistry. B 2008;112(37):11809-18.
2008: Cetinkol Ozgül Persil; Engelhart Aaron E; Nanjunda Rupesh K; Wilson W David; Hud Nicholas V
Submicromolar, selective G-quadruplex ligands from one pot: thermodynamic and structural studies of human telomeric DNA binding by azacyanines.
Chembiochem : a European journal of chemical biology 2008;9(12):1889-92.
2008: Rahimian Maryam; Miao Yi; Wilson W David
Influence of DNA structure on adjacent site cooperative binding.
The journal of physical chemistry. B 2008;112(29):8770-8.
2008: Wilson W David; Tanious Farial A; Mathis Amanda; Tevis Denise; Hall James Edwin; Boykin David W
Antiparasitic compounds that target DNA.
Biochimie 2008;90(7):999-1014.
2008: Peixoto Paul; Liu Yang; Depauw Sabine; Hildebrand Marie-Paule; Boykin David W; Bailly Christian; Wilson W David; David-Cordonnier Marie-Hélène
Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication.
Nucleic acids research 2008;36(10):3341-53.
2008: Brown Toni; Mackay Hilary; Turlington Mark; Sutterfield Arden; Smith Traci; Sielaff Alan; Westrate Laura; Bruce Chrystal; Kluza Jerome; O'Hare Caroline; Nguyen Binh; Wilson W David; Hartley John A; Lee Moses
Modifying the N-terminus of polyamides: PyImPyIm has improved sequence specificity over f-ImPyIm.
Bioorganic & medicinal chemistry 2008;16(9):5266-76.
2008: Cuenca Francisco; Greciano Olga; Gunaratnam Mekala; Haider Shozeb; Munnur Deeksha; Nanjunda Rupesh; Wilson W David; Neidle Stephen
Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.
Bioorganic & medicinal chemistry letters 2008;18(5):1668-73.
2008: Miao Yi; Cui Tengjiao; Leng Fenfei; Wilson W David
Inhibition of high-mobility-group A2 protein binding to DNA by netropsin: a biosensor-surface plasmon resonance assay.
Analytical biochemistry 2008;374(1):7-15.
2008: Rodríguez Fernando; Rozas Isabel; Kaiser Marcel; Brun Reto; Nguyen Binh; Wilson W David; García Rory Nelson; Dardonville Christophe
New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.
Journal of medicinal chemistry 2008;51(4):909-23.
2008: Cheng Mai-Kim; Modi Chetna; Cookson Jennifer C; Hutchinson Ian; Heald Robert A; McCarroll Andrew J; Missailidis Sotiris; Tanious Farial; Wilson W David; Mergny Jean-Louis; Laughton Charles A; Stevens Malcolm F G
Antitumor polycyclic acridines. 20. Search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents.
Journal of medicinal chemistry 2008;51(4):963-75.
2008: Mackay Hilary; Brown Toni; Sexton Jim S; Kotecha Minal; Nguyen Binh; Wilson W David; Kluza Jerome; Savic Boris; O'Hare Caroline; Hochhauser Daniel; Lee Moses; Hartley John A
Targeting the inverted CCAAT Box-2 of the topoisomerase IIalpha gene: DNA sequence selective recognition by a polyamide-intercalator as a staggered dimer.
Bioorganic & medicinal chemistry 2008;16(4):2093-102.
2008: Hu Laixing; Arafa Reem K; Ismail Mohamed A; Wenzler Tanja; Brun Reto; Munde Manoj; Wilson W David; Nzimiro Sandra; Samyesudhas Serene; Werbovetz Karl A; Boykin David W
Azaterphenyl diamidines as antileishmanial agents.
Bioorganic & medicinal chemistry letters 2008;18(1):247-51.
2008: Ismail Mohamed A; Arafa Reem K; Wenzler Tanja; Brun Reto; Tanious Farial A; Wilson W David; Boykin David W
Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.
Bioorganic & medicinal chemistry 2008;16(2):683-91.
2008: Tanious Farial A; Nguyen Binh; Wilson W David
Biosensor-surface plasmon resonance methods for quantitative analysis of biomolecular interactions.
Methods in cell biology 2008;84():53-77.
2007: Liu Yang; Kumar Arvind; Boykin David W; Wilson W David
Sequence and length dependent thermodynamic differences in heterocyclic diamidine interactions at AT base pairs in the DNA minor groove.
Biophysical chemistry 2007;131(1-3):1-14.
2007: Munde Manoj; Ismail Mohamed A; Arafa Reem; Peixoto Paul; Collar Catharine J; Liu Yang; Hu Laixing; David-Cordonnier Marie-Hélène; Lansiaux Amélie; Bailly Christian; Boykin David W; Wilson W David
Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.
Journal of the American Chemical Society 2007;129(44):13732-43.
2007: O'Hare C Caroline; Uthe Peter; Mackay Hilary; Blackmon Kevin; Jones Justin; Brown Toni; Nguyen Binh; Wilson W David; Lee Moses; Hartley John A
Sequence recognition in the minor groove of DNA by covalently linked formamido imidazole-pyrrole-imidazole polyamides: effect of H-pin linkage and linker length on selectivity and affinity.
Biochemistry 2007;46(42):11661-70.
2007: Wilson W David; Sugiyama Hiroshi
First International Meeting on Quadruplex DNA.
ACS chemical biology 2007;2(9):589-94.
2007: Roy Subhadeep; Tanious Farial A; Wilson W David; Ly Danith H; Armitage Bruce A
High-affinity homologous peptide nucleic acid probes for targeting a quadruplex-forming sequence from a MYC promoter element.
Biochemistry 2007;46(37):10433-43.
2007: Mathis Amanda M; Bridges Arlene S; Ismail Mohamed A; Kumar Arvind; Francesconi Iris; Anbazhagan Mariappan; Hu Qiyue; Tanious Farial A; Wenzler Tanja; Saulter Janelle; Wilson W David; Brun Reto; Boykin David W; Tidwell Richard R; Hall James Edwin
Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
Antimicrobial agents and chemotherapy 2007;51(8):2801-10.
2007: Tanious Farial A; Laine William; Peixoto Paul; Bailly Christian; Goodwin Kristie D; Lewis Mark A; Long Eric C; Georgiadis Millie M; Tidwell Richard R; Wilson W David
Unusually strong binding to the DNA minor groove by a highly twisted benzimidazole diphenylether: induced fit and bound water.
Biochemistry 2007;46(23):6944-56.
2007: Nguyen Binh; Tanious Farial A; Wilson W David
Biosensor-surface plasmon resonance: quantitative analysis of small molecule-nucleic acid interactions.
Methods (San Diego, Calif.) 2007;42(2):150-61.
2007: Munde Manoj; Lee Michael; Neidle Stephen; Arafa Reem; Boykin David W; Liu Yang; Bailly Christian; Wilson W David
Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex.
Journal of the American Chemical Society 2007;129(17):5688-98.
2007: Freyer Matthew W; Buscaglia Robert; Hollingsworth Amy; Ramos Joseph; Blynn Meredith; Pratt Rachael; Wilson W David; Lewis Edwin A
Break in the heat capacity change at 303 K for complex binding of netropsin to AATT containing hairpin DNA constructs.
Biophysical journal 2007;92(7):2516-22.
2007: Gonzalez Jose L; Stephens Chad E; Wenzler Tanja; Brun Reto; Tanious Farial A; Wilson W David; Barszcz Todd; Werbovetz Karl A; Boykin David W
Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes.
European journal of medicinal chemistry 2007;42(4):552-7.
2007: Freyer M W; Buscaglia R; Cashman D; Hyslop S; Wilson W D; Chaires J B; Lewis E A
Binding of netropsin to several DNA constructs: evidence for at least two different 1:1 complexes formed from an -AATT-containing ds-DNA construct and a single minor groove binding ligand.
Biophysical chemistry 2007;126(1-3):186-96.
2007: White Elizabeth W; Tanious Farial; Ismail Mohamed A; Reszka Anthony P; Neidle Stephen; Boykin David W; Wilson W David
Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge.
Biophysical chemistry 2007;126(1-3):140-53.
2007: Brown Toni; Taherbhai Zarmeen; Sexton Jim; Sutterfield Arden; Turlington Mark; Jones Justin; Stallings Lindsay; Stewart Michelle; Buchmueller Karen; Mackay Hilary; O'hare Caroline; Kluza Jerome; Nguyen Binh; Wilson David; Lee Moses; Hartley John A
Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin.
Bioorganic & medicinal chemistry 2007;15(1):474-83.
2006: Flores Lloyd V; Staples Andrew M; Mackay Hilary; Howard Cameron M; Uthe Peter B; Sexton Jim S; Buchmueller Karen L; Wilson W David; O'Hare Caroline; Kluza Jerome; Hochhauser Daniel; Hartley John A; Lee Moses
Synthesis and evaluation of an intercalator-polyamide hairpin designed to target the inverted CCAAT box 2 in the topoisomerase IIalpha promoter.
Chembiochem : a European journal of chemical biology 2006;7(11):1722-9.
2006: Chackal-Catoen Sarah; Miao Yi; Wilson W David; Wenzler Tanja; Brun Reto; Boykin David W
Dicationic DNA-targeted antiprotozoal agents: naphthalene replacement of benzimidazole.
Bioorganic & medicinal chemistry 2006;14(22):7434-45.
2006: Ismail Mohamed A; Arafa Reem K; Brun Reto; Wenzler Tanja; Miao Yi; Wilson W David; Generaux Claudia; Bridges Arlene; Hall James E; Boykin David W
Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
Journal of medicinal chemistry 2006;49(17):5324-32.
2006: Freyer Matthew W; Buscaglia Robert; Nguyen Binh; Wilson W David; Lewis Edwin A
Binding of netropsin and 4,6-diamidino-2-phenylindole to an A2T2 DNA hairpin: a comparison of biophysical techniques.
Analytical biochemistry 2006;355(2):259-66.
2006: Goodwin Kristie D; Lewis Mark A; Tanious Farial A; Tidwell Richard R; Wilson W David; Georgiadis Millie M; Long Eric C
A high-throughput, high-resolution strategy for the study of site-selective DNA binding agents: analysis of a "highly twisted" benzimidazole-diamidine.
Journal of the American Chemical Society 2006;128(24):7846-54.
2006: Dardonville Christophe; Barrett Michael P; Brun Reto; Kaiser Marcel; Tanious Farial; Wilson W David
DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.
Journal of medicinal chemistry 2006;49(12):3748-52.
2006: Athri Prashanth; Wenzler Tanja; Ruiz Patricia; Brun Reto; Boykin David W; Tidwell Richard; Wilson W David
3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity.
Bioorganic & medicinal chemistry 2006;14(9):3144-52.
2006: Nguyen Binh; Stanek Jaroslav; Wilson W David
Binding-linked protonation of a DNA minor-groove agent.
Biophysical journal 2006;90(4):1319-28.
2006: Moore Michael J B; Schultes Christoph M; Cuesta Javier; Cuenca Francisco; Gunaratnam Mekala; Tanious Farial A; Wilson W David; Neidle Stephen
Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.
Journal of medicinal chemistry 2006;49(2):582-99.
2005: Buchmueller Karen L; Taherbhai Zarmeen; Howard Cameron M; Bailey Suzanna L; Nguyen Binh; O'Hare Caroline; Hochhauser Daniel; Hartley John A; Wilson W David; Lee Moses
Design of a hairpin polyamide, ZT65B, for targeting the inverted CCAAT box (ICB) site in the multidrug resistant (MDR1) gene.
Chembiochem : a European journal of chemical biology 2005;6(12):2305-11.
2005: Ismail Mohamed A; Batista-Parra Adalgisa; Miao Yi; Wilson W David; Wenzler Tanja; Brun Reto; Boykin David W
Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents.
Bioorganic & medicinal chemistry 2005;13(24):6718-26.
2005: Miao Yi; Lee Michael P H; Parkinson Gary N; Batista-Parra Adalgisa; Ismail Mohamed A; Neidle Stephen; Boykin David W; Wilson W David
Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove.
Biochemistry 2005;44(45):14701-8.
2005: Arafa Reem K; Brun Reto; Wenzler Tanja; Tanious Farial A; Wilson W David; Stephens Chad E; Boykin David W
Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.
Journal of medicinal chemistry 2005;48(17):5480-8.
2005: Wilson W David; Nguyen Binh; Tanious Farial A; Mathis Amanda; Hall James Edwin; Stephens Chad E; Boykin David W
Dications that target the DNA minor groove: compound design and preparation, DNA interactions, cellular distribution and biological activity.
Current medicinal chemistry. Anti-cancer agents 2005;5(4):389-408.
2005: Rezler Evonne M; Seenisamy Jeyaprakashnarayanan; Bashyam Sridevi; Kim Mu-Yong; White Elizabeth; Wilson W David; Hurley Laurence H
Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structure.
Journal of the American Chemical Society 2005;127(26):9439-47.
2005: Strekowski Lucjan; Cegla Marek T; Honkan Vidya; Buczak Henryk; Winkeljohn W Rucks; Baumstark Alfons L; Wilson W David
Chiral discrimination in binding of enantiomers of 2-(aminoalkoxy)-substituted 4-(2-thienyl)pyrimidines and 4,6-bis(2-thienyl)pyrimidines with duplex DNA.
Bioorganic & medicinal chemistry letters 2005;15(11):2720-3.
2005: Seenisamy Jeyaprakashnarayanan; Bashyam Sridevi; Gokhale Vijay; Vankayalapati Hariprasad; Sun Daekyu; Siddiqui-Jain Adam; Streiner Nicole; Shin-Ya Kazuo; White Elizabeth; Wilson W David; Hurley Laurence H
Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.
Journal of the American Chemical Society 2005;127(9):2944-59.
2005: Bailly Christian; Arafa Reem K; Tanious Farial A; Laine William; Tardy Christèle; Lansiaux Amélie; Colson Pierre; Boykin David W; Wilson W David
Molecular determinants for DNA minor groove recognition: design of a bis-guanidinium derivative of ethidium that is highly selective for AT-rich DNA sequences.
Biochemistry 2005;44(6):1941-52.
2005: Strekowski Lucjan; Hojjat Maryam; Wolinska Ewa; Parker Alesia N; Paliakov Ekaterina; Gorecki Tadeusz; Tanious Farial A; Wilson W David
New triple-helix DNA stabilizing agents.
Bioorganic & medicinal chemistry letters 2005;15(4):1097-100.
2005: Buchmueller Karen L; Staples Andrew M; Howard Cameron M; Horick Sarah M; Uthe Peter B; Le N Minh; Cox Kari K; Nguyen Binh; Pacheco Kimberly A O; Wilson W David; Lee Moses
Extending the language of DNA molecular recognition by polyamides: unexpected influence of imidazole and pyrrole arrangement on binding affinity and specificity.
Journal of the American Chemical Society 2005;127(2):742-50.
2005: Buchmueller Karen L; Staples Andrew M; Uthe Peter B; Howard Cameron M; Pacheco Kimberly A O; Cox Kari K; Henry James A; Bailey Suzanna L; Horick Sarah M; Nguyen Binh; Wilson W David; Lee Moses
Molecular recognition of DNA base pairs by the formamido/pyrrole and formamido/imidazole pairings in stacked polyamides.
Nucleic acids research 2005;33(3):912-21.
2004: Strekowski Lucjan; Parker Alesia N; Hojjat Maryam; Say Martial; Zegrocka-Stendel Oliwia; Patterson Steven E; Tanious Farial A; Wilson W David
Triple-helix DNA selective 2-(2-naphthyl)quinoline intercalators.
Acta poloniae pharmaceutica 2004;61 Suppl():70-2.
2004: Dias Nathalie; Jacquemard Ulrich; Baldeyrou Brigitte; Tardy Christelle; Lansiaux Amélie; Colson Pierre; Tanious Farial; Wilson W David; Routier Sylvain; Mérour Jean-Yves; Bailly Christian
Targeting DNA with novel diphenylcarbazoles.
Biochemistry 2004;43(48):15169-78.
2004: Chaires Jonathan B; Ren Jinsong; Hamelberg Donald; Kumar Arvind; Pandya Vandna; Boykin David W; Wilson W David
Structural selectivity of aromatic diamidines.
Journal of medicinal chemistry 2004;47(23):5729-42.
2004: Mallena Sirish; Lee Michael P H; Bailly Christian; Neidle Stephen; Kumar Arvind; Boykin David W; Wilson W David
Thiophene-based diamidine forms a "super" at binding minor groove agent.
Journal of the American Chemical Society 2004;126(42):13659-69.
2004: Ismail Mohamed A; Brun Reto; Wenzler Tanja; Tanious Farial A; Wilson W David; Boykin David W
Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents.
Bioorganic & medicinal chemistry 2004;12(20):5405-13.
2004: Henry James A; Le N Minh; Nguyen Binh; Howard Cameron M; Bailey Suzanna L; Horick Sarah M; Buchmueller Karen L; Kotecha Minal; Hochhauser Daniel; Hartley John A; Wilson W David; Lee Moses
Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: design, synthesis, molecular biology, and biophysical studies.
Biochemistry 2004;43(38):12249-57.
2004: De Souza E M; Lansiaux A; Bailly C; Wilson W D; Hu Q; Boykin D W; Batista M M; Araújo-Jorge T C; Soeiro M N C
Phenyl substitution of furamidine markedly potentiates its anti-parasitic activity against Trypanosoma cruzi and Leishmania amazonensis.
Biochemical pharmacology 2004;68(4):593-600.
2004: Ismail Mohamed A; Brun Reto; Wenzler Tanja; Tanious Farial A; Wilson W David; Boykin David W
Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents.
Journal of medicinal chemistry 2004;47(14):3658-64.
2004: Nguyen Binh; Hamelberg Donald; Bailly Christian; Colson Pierre; Stanek Jaroslav; Brun Reto; Neidle Stephen; Wilson W David
Characterization of a novel DNA minor-groove complex.
Biophysical journal 2004;86(2):1028-41.
2004: Tanious Farial A; Hamelberg Donald; Bailly Christian; Czarny Agnieska; Boykin David W; Wilson W David
DNA sequence dependent monomer-dimer binding modulation of asymmetric benzimidazole derivatives.
Journal of the American Chemical Society 2004;126(1):143-53.
2004: Lacy Eilyn R; Nguyen Binh; Le Minh; Cox Kari K; OHare Caroline; Hartley John A; Lee Moses; Wilson W David
Energetic basis for selective recognition of T*G mismatched base pairs in DNA by imidazole-rich polyamides.
Nucleic acids research 2004;32(6):2000-7.
2003: Tanious Farial; Wilson W David; Wang Lei; Kumar Arvind; Boykin David W; Marty Carine; Baldeyrou Brigitte; Bailly Christian
Cooperative dimerization of a heterocyclic diamidine determines sequence-specific DNA recognition.
Biochemistry 2003;42(46):13576-86.
2003: Ismail Mohamed A; Brun Reto; Easterbrook Judy D; Tanious Farial A; Wilson W David; Boykin David W
Synthesis and antiprotozoal activity of aza-analogues of furamidine.
Journal of medicinal chemistry 2003;46(22):4761-9.
2003: Harrison R John; Cuesta Javier; Chessari Gianni; Read Martin A; Basra Sanji K; Reszka Anthony P; Morrell James; Gowan Sharon M; Incles Christopher M; Tanious Farial A; Wilson W David; Kelland Lloyd R; Neidle Stephen
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.
Journal of medicinal chemistry 2003;46(21):4463-76.
2003: Stephens Chad E; Brun Reto; Salem Manar M; Werbovetz Karl A; Tanious Farial; Wilson W David; Boykin David W
The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.
Bioorganic & medicinal chemistry letters 2003;13(12):2065-9.
2003: Teulade-Fichou M P; Hounsou C; Guittat L; Mergny J L; Alberti P; Carrasco C; Bailly C; Lehn J M; Wilson W D
Molecular recognition of quadruplex DNA by quinacridine derivatives.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1483-5.
2003: Teulade-Fichou Marie-Paule; Carrasco Carolina; Guittat Lionel; Bailly Christian; Alberti Patrizia; Mergny Jean-Louis; David Arnaud; Lehn Jean-Marie; Wilson W David
Selective recognition of G-qQuadruplex telomeric DNA by a bis(quinacridine) macrocycle.
Journal of the American Chemical Society 2003;125(16):4732-40.
2003: Strekowski Lucjan; Say Martial; Zegrocka Oliwia; Tanious Farial A; Wilson W David; Manzel Lori; Macfarlane Donald E
Bis-4-aminoquinolines: novel triple-helix DNA intercalators and antagonists of immunostimulatory CpG-oligodeoxynucleotides.
Bioorganic & medicinal chemistry 2003;11(6):1079-85.
2003: Bailly Christian; Chessari Gianni; Carrasco Carolina; Joubert Alexandra; Mann John; Wilson W David; Neidle Stephen
Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition.
Nucleic acids research 2003;31(5):1514-24.
2002: Lansiaux Amélie; Tanious Farial; Mishal Zohar; Dassonneville Laurent; Kumar Arvind; Stephens Chad E; Hu Qiyue; Wilson W David; Boykin David W; Bailly Christian
Distribution of furamidine analogues in tumor cells: targeting of the nucleus or mitochondria depending on the amidine substitution.
Cancer research 2002;62(24):7219-29.
2002: Carrasco Carolina; Rosu Frédéric; Gabelica Valérie; Houssier Claude; De Pauw Edwin; Garbay-Jaureguiberry Christiane; Roques Bernard; Wilson W David; Chaires Jonathan B; Waring Michael J; Bailly Christian
Tight binding of the antitumor drug ditercalinium to quadruplex DNA.
Chembiochem : a European journal of chemical biology 2002;3(12):1235-41.
2002: Nguyen Binh; Lee Michael P H; Hamelberg Donald; Joubert Alexandra; Bailly Christian; Brun Reto; Neidle Stephen; Wilson W David
Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove.
Journal of the American Chemical Society 2002;124(46):13680-1.
2002: Hamelberg Donald; Williams Loren Dean; Wilson W David
Effect of a neutralized phosphate backbone on the minor groove of B-DNA: molecular dynamics simulation studies.
Nucleic acids research 2002;30(16):3615-23.
2002: Lansiaux Amélie; Dassonneville Laurent; Facompré Michaël; Kumar Arvind; Stephens Chad E; Bajic Miroslav; Tanious Farial; Wilson W David; Boykin David W; Bailly Christian
Distribution of furamidine analogues in tumor cells: influence of the number of positive charges.
Journal of medicinal chemistry 2002;45(10):1994-2002.
2002: Lacy Eilyn R; Cox Kari K; Wilson W David; Lee Moses
Recognition of T*G mismatched base pairs in DNA by stacked imidazole-containing polyamides: surface plasmon resonance and circular dichroism studies.
Nucleic acids research 2002;30(8):1834-41.
2002: Carrasco Carolina; Facompré Michaël; Chisholm John D; Van Vranken David L; Wilson W David; Bailly Christian
DNA sequence recognition by the indolocarbazole antitumor antibiotic AT2433-B1 and its diastereoisomer.
Nucleic acids research 2002;30(8):1774-81.
2002: Nguyen Binh; Tardy Christelle; Bailly Christian; Colson Pierre; Houssier Claude; Kumar Arvind; Boykin David W; Wilson W David
Influence of compound structure on affinity, sequence selectivity, and mode of binding to DNA for unfused aromatic dications related to furamidine.
Biopolymers 2002;63(5):281-97.
2002: Wang Lei; Kumar Arvind; Boykin David W; Bailly Christian; Wilson W David
Comparative thermodynamics for monomer and dimer sequence-dependent binding of a heterocyclic dication in the DNA minor groove.
Journal of molecular biology 2002;317(3):361-74.
2002: Wilson W David
Tech.Sight. Analyzing biomolecular interactions.
Science (New York, N.Y.) 2002;295(5562):2103-5.
2002: Lacy Eilyn R; Le N Minh; Price Carly A; Lee Moses; Wilson W David
Influence of a terminal formamido group on the sequence recognition of DNA by polyamides.
Journal of the American Chemical Society 2002;124(10):2153-63.
2001: Bilik P; Tanious F; Kumar A; Wilson W D; Boykin D W; Colson P; Houssier C; Facompré M; Tardy C; Bailly C
Novel dications with unfused aromatic systems: trithiophene and trifuran derivatives of furimidazoline.
Chembiochem : a European journal of chemical biology 2001;2(7-8):559-69.
2001: Bailly C; Tardy C; Wang L; Armitage B; Hopkins K; Kumar A; Schuster G B; Boykin D W; Wilson W D
Recognition of ATGA sequences by the unfused aromatic dication DB293 forming stacked dimers in the DNA minor groove.
Biochemistry 2001;40(33):9770-9.
2001: Hamelberg D; Williams L D; Wilson W D
Influence of the dynamic positions of cations on the structure of the DNA minor groove: sequence-dependent effects.
Journal of the American Chemical Society 2001;123(32):7745-55.
2001: Tanious F A; Wilson W D; Patrick D A; Tidwell R R; Colson P; Houssier C; Tardy C; Bailly C
Sequence-dependent binding of bis-amidine carbazole dications to DNA.
European journal of biochemistry / FEBS 2001;268(12):3455-64.
2001: Xiao G; Kumar A; Li K; Rigl C T; Bajic M; Davis T M; Boykin D W; Wilson W D
Inhibition of the HIV-1 rev-RRE complex formation by unfused aromatic cations.
Bioorganic & medicinal chemistry 2001;9(5):1097-113.
2001: Stephens C E; Tanious F; Kim S; Wilson W D; Schell W A; Perfect J R; Franzblau S G; Boykin D W
Diguanidino and "reversed" diamidino 2,5-diarylfurans as antimicrobial agents.
Journal of medicinal chemistry 2001;44(11):1741-8.
2001: Carrasco C; Vezin H; Wilson W D; Ren J; Chaires J B; Bailly C
DNA binding properties of the indolocarbazole antitumor drug NB-506.
Anti-cancer drug design 2001;16(2-3):99-107.
2001: Read M; Harrison R J; Romagnoli B; Tanious F A; Gowan S H; Reszka A P; Wilson W D; Kelland L R; Neidle S
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):4844-9.
2001: Wang L; Carrasco C; Kumar A; Stephens C E; Bailly C; Boykin D W; Wilson W D
Evaluation of the influence of compound structure on stacked-dimer formation in the DNA minor groove.
Biochemistry 2001;40(8):2511-21.
2001: Li K; Davis T M; Bailly C; Kumar A; Boykin D W; Wilson W D
A heterocyclic inhibitor of the REV-RRE complex binds to RRE as a dimer.
Biochemistry 2001;40(5):1150-8.
2001: Davis T M; Wilson W D
Surface plasmon resonance biosensor analysis of RNA-small molecule interactions.
Methods in enzymology 2001;340():22-51.
2000: Kawanishi S; Oikawa S; Kawanishi M; Sugiyama H; Saito I; Strekowski L; Wilson W D
Amplification of pepleomycin-mediated DNA cleavage and apoptosis by unfused aromatic cations.
Biochemistry 2000;39(43):13210-5.
2000: Tanious F A; Ding D; Patrick D A; Bailly C; Tidwell R R; Wilson W D
Effects of compound structure on carbazole dication-DNA complexes: tests of the minor-groove complex models.
Biochemistry 2000;39(39):12091-101.
2000: Davis T M; Wilson W D
Determination of the refractive index increments of small molecules for correction of surface plasmon resonance data.
Analytical biochemistry 2000;284(2):348-53.
2000: Mazur S; Tanious F A; Ding D; Kumar A; Boykin D W; Simpson I J; Neidle S; Wilson W D
A thermodynamic and structural analysis of DNA minor-groove complex formation.
Journal of molecular biology 2000;300(2):321-37.
2000: Wilson W D; Li K
Targeting RNA with small molecules.
Current medicinal chemistry 2000;7(1):73-98.
2000: Wang L; Bailly C; Kumar A; Ding D; Bajic M; Boykin D W; Wilson W D
Specific molecular recognition of mixed nucleic acid sequences: an aromatic dication that binds in the DNA minor groove as a dimer.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):12-6.
1999: Fernandez-Saiz M; Henderson P T; Wilson W D; Schuster G B
Selective photocleavage of DNA and RNA by anthraquinone derivatives: targeting the single-strand region of hairpin structures.
Photochemistry and photobiology 1999;70(6):847-52.
1999: Patrick D A; Hall J E; Bender B C; McCurdy D R; Wilson W D; Tanious F A; Saha S; Tidwell R R
Synthesis and anti-Pneumocystis carinii pneumonia activity of novel dicationic dibenzothiophenes and orally active prodrugs.
European journal of medicinal chemistry 1999;34(7-8):575-83.
1999: Gelus N; Bailly C; Hamy F; Klimkait T; Wilson W D; Boykin D W
Inhibition of HIV-1 Tat-TAR interaction by diphenylfuran derivatives: effects of the terminal basic side chains.
Bioorganic & medicinal chemistry 1999;7(6):1089-96.
1999: Francesconi I; Wilson W D; Tanious F A; Hall J E; Bender B C; Tidwell R R; McCurdy D; Boykin D W
2,4-Diphenyl furan diamidines as novel anti-Pneumocystis carinii pneumonia agents.
Journal of medicinal chemistry 1999;42(12):2260-5.
1999: Bailly C; Dassonneville L; Carrasco C; Lucas D; Kumar A; Boykin D W; Wilson W D
Relationships between topoisomerase II inhibition, sequence-specificity and DNA binding mode of dicationic diphenylfuran derivatives.
Anti-cancer drug design 1999;14(1):47-60.
1998: Hopkins K T; Wilson W D; Bender B C; McCurdy D R; Hall J E; Tidwell R R; Kumar A; Bajic M; Boykin D W
Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
Journal of medicinal chemistry 1998;41(20):3872-8.
1998: Ding D; Gryaznov S M; Wilson W D
NMR solution structure of the N3' --> P5' phosphoramidate duplex d(CGCGAATTCGCG)2 by the iterative relaxation matrix approach.
Biochemistry 1998;37(35):12082-93.
1998: Boykin D W; Kumar A; Xiao G; Wilson W D; Bender B C; McCurdy D R; Hall J E; Tidwell R R
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
Journal of medicinal chemistry 1998;41(1):124-9.
1997: Tanious F A; Ding D; Patrick D A; Tidwell R R; Wilson W D
A new type of DNA minor-groove complex: carbazole dication-DNA interactions.
Biochemistry 1997;36(49):15315-25.
1997: Li K; Fernandez-Saiz M; Rigl C T; Kumar A; Ragunathan K G; McConnaughie A W; Boykin D W; Schneider H J; Wilson W D
Design and analysis of molecular motifs for specific recognition of RNA.
Bioorganic & medicinal chemistry 1997;5(6):1157-72.
1997: Zapp M L; Young D W; Kumar A; Singh R; Boykin D W; Wilson W D; Green M R
Modulation of the Rev-RRE interaction by aromatic heterocyclic compounds.
Bioorganic & medicinal chemistry 1997;5(6):1149-55.
1997: Rigl C T; Lloyd D H; Tsou D S; Gryaznov S M; Wilson W D
Structural RNA mimetics: N3'-->P5' phosphoramidate DNA analogs of HIV-1 RRE and TAR RNA form A-type helices that bind specifically to Rev and Tat-related peptides.
Biochemistry 1997;36(3):650-9.
1997: Shi P Y; Sklyarevskaya T; Kebbekus P; Brinton M; Wilson W D
Analysis of the structure and folding of the 3' genomic RNA of flaviviruses.
Nucleic acids symposium series 1997;(36):52-5.
1997: Wilson W D; Tanious F A; Fernandez-Saiz M; Rigl C T
Evaluation of drug-nucleic acid interactions by thermal melting curves.
Methods in molecular biology (Clifton, N.J.) 1997;90():219-40.
1996: Trent J O; Clark G R; Kumar A; Wilson W D; Boykin D W; Hall J E; Tidwell R R; Blagburn B L; Neidle S
Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2.
Journal of medicinal chemistry 1996;39(23):4554-62.
1996: Ratmeyer L; Zapp M L; Green M R; Vinayak R; Kumar A; Boykin D W; Wilson W D
Inhibition of HIV-1 Rev-RRE interaction by diphenylfuran derivatives.
Biochemistry 1996;35(42):13689-96.
1996: Strekowski L; Gulevich Y; Baranowski T C; Parker A N; Kiselyov A S; Lin S Y; Tanious F A; Wilson W D
Synthesis and structure-DNA binding relationship analysis of DNA triple-helix specific intercalators.
Journal of medicinal chemistry 1996;39(20):3980-3.
1996: Laughton C A; Tanious F; Nunn C M; Boykin D W; Wilson W D; Neidle S
A crystallographic and spectroscopic study of the complex between d(CGCGAATTCGCG)2 and 2,5-bis(4-guanylphenyl)furan, an analogue of berenil. Structural origins of enhanced DNA-binding affinity.
Biochemistry 1996;35(18):5655-61.
1996: Shi P Y; Brinton M A; Veal J M; Zhong Y Y; Wilson W D
Evidence for the existence of a pseudoknot structure at the 3' terminus of the flavivirus genomic RNA.
Biochemistry 1996;35(13):4222-30.
1996: Wilson W D; Ratmeyer L; Zhao M; Ding D; McConnaughie A W; Kumar A; Boykin D W
Design and analysis of RNA structure-specific agents as potential antivirals.
Journal of molecular recognition : JMR 1996;9(2):187-96.
1996: Lombardy R L; Tanious F A; Ramachandran K; Tidwell R R; Wilson W D
Synthesis and DNA interactions of benzimidazole dications which have activity against opportunistic infections.
Journal of medicinal chemistry 1996;39(7):1452-62.
1996: Ding D; Grayaznov S M; Lloyd D H; Chandrasekaran S; Yao S; Ratmeyer L; Pan Y; Wilson W D
An oligodeoxyribonucleotide N3'--> P5' phosphoramidate duplex forms an A-type helix in solution.
Nucleic acids research 1996;24(2):354-60.
1995: Yao S; Wilson W D
1D and 2D 1H NMR studies on bisantrene complexes with short DNA oligomers.
Science in China. Series B, Chemistry, life sciences & earth sciences 1995;38(12):1462-72.
1995: Zhao M; Ratmeyer L; Peloquin R G; Yao S; Kumar A; Spychala J; Boykin D W; Wilson W D
Small changes in cationic substituents of diphenylfuran derivatives have major effects on the binding affinity and the binding mode with RNA helical duplexes.
Bioorganic & medicinal chemistry 1995;3(6):785-94.
1995: Gryaznov S M; Lloyd D H; Chen J K; Schultz R G; DeDionisio L A; Ratmeyer L; Wilson W D
Oligonucleotide N3'-->P5' phosphoramidates.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(13):5798-802.
1995: Chandler S P; Strekowski L; Wilson W D; Fox K R
Footprinting studies on ligands which stabilize DNA triplexes: effects on stringency within a parallel triple helix.
Biochemistry 1995;34(21):7234-42.
1995: Boykin D W; Kumar A; Spychala J; Zhou M; Lombardy R J; Wilson W D; Dykstra C C; Jones S K; Hall J E; Tidwell R R
Dicationic diarylfurans as anti-Pneumocystis carinii agents.
Journal of medicinal chemistry 1995;38(6):912-6.
1994: Cassidy S A; Strekowski L; Wilson W D; Fox K R
Effect of a triplex-binding ligand on parallel and antiparallel DNA triple helices using short unmodified and acridine-linked oligonucleotides.
Biochemistry 1994;33(51):15338-47.
1994: McMurray C T; Juranic N; Chandrasekaran S; Macura S; Li Y; Jones R L; Wilson W D
Hairpin formation within the human enkephalin enhancer region. 2. Structural studies.
Biochemistry 1994;33(39):11960-70.
1994: Wilson W D; Mizan S; Tanious F A; Yao S; Zon G
The interaction of intercalators and groove-binding agents with DNA triple-helical structures: the influence of ligand structure, DNA backbone modifications and sequence.
Journal of molecular recognition : JMR 1994;7(2):89-98.
1994: Ratmeyer L; Vinayak R; Zhong Y Y; Zon G; Wilson W D
Sequence specific thermodynamic and structural properties for DNA.RNA duplexes.
Biochemistry 1994;33(17):5298-304.
1994: Tanious F A; Spychala J; Kumar A; Greene K; Boykin D W; Wilson W D
Different binding mode in AT and GC sequences for unfused-aromatic dications.
Journal of biomolecular structure & dynamics 1994;11(5):1063-83.
1994: McConnaughie A W; Spychala J; Zhao M; Boykin D; Wilson W D
Design and synthesis of RNA-specific groove-binding cations: implications for antiviral drug design.
Journal of medicinal chemistry 1994;37(8):1063-9.
1994: Greene K L; Jones R L; Li Y; Robinson H; Wang A H; Zon G; Wilson W D
Solution structure of a GA mismatch DNA sequence, d(CCATGAATGG)2, determined by 2D NMR and structural refinement methods.
Biochemistry 1994;33(5):1053-62.
1994: Zhao M; Janda L; Nguyen J; Strekowski L; Wilson W D
The interaction of substituted 2-phenylquinoline intercalators with poly(A).poly(U): classical and threading intercalation modes with RNA.
Biopolymers 1994;34(1):61-73.
1993: Wilson W D; Tanious F A; Mizan S; Yao S; Kiselyov A S; Zon G; Strekowski L
DNA triple-helix specific intercalators as antigene enhancers: unfused aromatic cations.
Biochemistry 1993;32(40):10614-21.
1993: Wilson W D; Ratmeyer L; Zhao M; Strekowski L; Boykin D
The search for structure-specific nucleic acid-interactive drugs: effects of compound structure on RNA versus DNA interaction strength.
Biochemistry 1993;32(15):4098-104.
1993: Kibler-Herzog L; Zon G; Whittier G; Mizan S; Wilson W D
Stabilities of duplexes and triplexes of dA19 + dT19 with alternating methylphosphonate and phosphodiester linkages.
Anti-cancer drug design 1993;8(1):65-79.
1992: Tanious F A; Jenkins T C; Neidle S; Wilson W D
Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs.
Biochemistry 1992;31(46):11632-40.
1992: Strekowski L; Mokrosz J L; Wilson W D; Mokrosz M J; Strekowski A
Stereoelectronic factors in the interaction with DNA of small aromatic molecules substituted with a short cationic chain: importance of the polarity of the aromatic system of the molecule.
Biochemistry 1992;31(44):10802-8.
1992: Yao S; Wilson W D
A molecular mechanics investigation of RNA complexes. I. Ethidium intercalation in an HIV-1 TAR RNA sequence with an unpaired adenosine.
Journal of biomolecular structure & dynamics 1992;10(2):367-87.
1992: Ratmeyer L S; Vinayak R; Zon G; Wilson W D
An ethidium analogue that binds with high specificity to a base-bulged duplex from the TAR RNA region of the HIV-I genome.
Journal of medicinal chemistry 1992;35(5):966-8.
1992: Tanious F A; Veal J M; Buczak H; Ratmeyer L S; Wilson W D
DAPI (4',6-diamidino-2-phenylindole) binds differently to DNA and RNA: minor-groove binding at AT sites and intercalation at AU sites.
Biochemistry 1992;31(12):3103-12.
1991: McKenna R; Neidle S; Wilson W D
Structures of 1-(3,3-dimethylamino)propyl naphtho[2,1-b]thiophene-4- carboxylate and N-(3,3-dimethylamino)propyl-8-methoxynaphtho[2,1- b]thiophene-4-carboxamide, intercalators into double-helical DNA.
Acta crystallographica. Section C, Crystal structure communications 1991;47 ( Pt 11)():2511-3.
1991: Hopkins H P; Ming Y; Wilson W D; Boykin D W
Intercalation binding of 6-substituted naphthothiopheneamides to DNA: enthalpy and entropy components.
Biopolymers 1991;31(9):1105-14.
1991: Li Y; Zon G; Wilson W D
Thermodynamics of DNA duplexes with adjacent G.A mismatches.
Biochemistry 1991;30(30):7566-72.
1991: Robledo-Luiggi C; Wilson W D; Pares E; Vera M; Martinez C S; Santiago D
Partial intercalation with DNA of peptides containing two aromatic amino acids.
Biopolymers 1991;31(7):907-17.
1991: Veal J M; Wilson W D
Modeling of nucleic acid complexes with cationic ligands: a specialized molecular mechanics force field and its application.
Journal of biomolecular structure & dynamics 1991;8(6):1119-45.
1991: Kibler-Herzog L; Zon G; Uznanski B; Whittier G; Wilson W D
Duplex stabilities of phosphorothioate, methylphosphonate, and RNA analogs of two DNA 14-mers.
Nucleic acids research 1991;19(11):2979-86.
1991: Tanious F A; Yen S F; Wilson W D
Kinetic and equilibrium analysis of a threading intercalation mode: DNA sequence and ion effects.
Biochemistry 1991;30(7):1813-9.
1991: Strekowski L; Wilson W D; Mokrosz J L; Mokrosz M J; Harden D B; Tanious F A; Wydra R L; Crow S A
Quantitative structure-activity relationship analysis of cation-substituted polyaromatic compounds as potentiators (amplifiers) of bleomycin-mediated degradation of DNA.
Journal of medicinal chemistry 1991;34(2):580-8.
1991: McMurray C T; Wilson W D; Douglass J O
Hairpin formation within the enhancer region of the human enkephalin gene.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):666-70.
1991: Li Y; Zon G; Wilson W D
NMR and molecular modeling evidence for a G.A mismatch base pair in a purine-rich DNA duplex.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(1):26-30.
1990: Veal J M; Li Y; Zimmerman S C; Lamberson C R; Cory M; Zon G; Wilson W D
Interaction of a macrocyclic bisacridine with DNA.
Biochemistry 1990;29(49):10918-27.
1990: Wilson W D; Tanious F A; Barton H J; Jones R L; Fox K; Wydra R L; Strekowski L
DNA sequence dependent binding modes of 4',6-diamidino-2-phenylindole (DAPI).
Biochemistry 1990;29(36):8452-61.
1990: Clark G R; Brown D G; Sanderson M R; Chwalinski T; Neidle S; Veal J M; Jones R L; Wilson W D; Zon G; Garman E
Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study.
Nucleic acids research 1990;18(18):5521-8.
1990: Strickland J A; Marzilli L G; Wilson W D
Binding of meso-tetrakis(N-methylpyridiniumyl)porphyrin isomers to DNA: quantitative comparison of the influence of charge distribution and copper(II) derivatization.
Biopolymers 1990;29(8-9):1307-23.
1990: Kibler-Herzog L; Kell B; Zon G; Shinozuka K; Mizan S; Wilson W D
Sequence dependent effects in methylphosphonate deoxyribonucleotide double and triple helical complexes.
Nucleic acids research 1990;18(12):3545-55.
1990: Zuo E T; Tanious F A; Wilson W D; Zon G; Tan G S; Wartell R M
Effect of base-pair sequence on the conformations and thermally induced transitions in oligodeoxyribonucleotides containing only AT base pairs.
Biochemistry 1990;29(18):4446-56.
1990: Wilson W D; Barton H J; Tanious F A; Kong S B; Strekowski L
The interaction with DNA of unfused aromatic systems containing terminal piperazino substituents. Intercalation and groove-binding.
Biophysical chemistry 1990;35(2-3):227-43.
1990: Hopkins H P; Fumero J; Wilson W D
Temperature dependence of enthalpy changes for ethidium and propidium binding to DNA: effect of alkylamine chains.
Biopolymers 1990;29(2):449-59.
1990: Wilson W D; Tanious F A; Barton H J; Wydra R L; Jones R L; Boykin D W; Strekowski L
The interaction of unfused polyaromatic heterocycles with DNA: intercalation, groove-binding and bleomycin amplification.
Anti-cancer drug design 1990;5(1):31-42.
1989: Strekowski L; Harden D B; Wydra R L; Stewart K D; Wilson W D
Molecular basis for potentiation of bleomycin-mediated degradation of DNA by polyamines. Experimental and molecular mechanical studies.
Journal of molecular recognition : JMR 1989;2(4):158-66.
1989: Wilson W D; Tanious F A; Watson R A; Barton H J; Strekowska A; Harden D B; Strekowski L
Interaction of unfused tricyclic aromatic cations with DNA: a new class of intercalators.
Biochemistry 1989;28(5):1984-92.
1989: Elliott J A; Wilson W D; Shea R G; Hartley J A; Reszka K; Lown J W
Interaction of bisantrene anti-cancer agents with DNA: footprinting, structural requirements for DNA unwinding, kinetics and mechanism of binding and correlation of structural and kinetic parameters with anti-cancer activity.
Anti-cancer drug design 1989;3(4):271-82.
1988: Strekowski L; Mokrosz J L; Wilson W D
A biphasic nature of the bleomycin-mediated degradation of DNA.
FEBS letters 1988;241(1-2):24-8.
1988: Strickland J A; Marzilli L G; Gay K M; Wilson W D
Porphyrin and metalloporphyrin binding to DNA polymers: rate and equilibrium binding studies.
Biochemistry 1988;27(24):8870-8.
1988: Scott E V; Zon G; Marzilli L G; Wilson W D
2D NMR investigation of the binding of the anticancer drug actinomycin D to duplexed dATGCGCAT: conformational features of the unique 2:1 adduct.
Biochemistry 1988;27(20):7940-51.
1988: Fairley T; Molock F; Boykin D W; Wilson W D
The interaction of multiply charged intercalating heterocycles with DNA.
Biopolymers 1988;27(9):1433-47.
1988: Jones R L; Scott E V; Zon G; Marzilli L G; Wilson W D
An NMR investigation of the binding of the anticancer drug actinomycin D to oligodeoxyribonucleotides with isolated 5'd(GC)3' binding sites.
Biochemistry 1988;27(16):6021-6.
1988: Strekowski L; Mokrosz M; Mokrosz J L; Strekowska A; Allison S A; Wilson W D
Amplification of bleomycin-mediated degradation of DNA by polyamines.
Anti-cancer drug design 1988;3(2):79-89.
1988: Wilson W D; Dotrong M H; Zuo E T; Zon G
Unusual duplex formation in purine rich oligodeoxyribonucleotides.
Nucleic acids research 1988;16(11):5137-51.
1988: Strekowski L; Mokrosz J L; Tanious F A; Watson R A; Harden D; Mokrosz M; Edwards W D; Wilson W D
Molecular basis for bleomycin amplification: conformational and stereoelectronic effects in unfused amplifiers.
Journal of medicinal chemistry 1988;31(6):1231-40.
1988: Strekowski L; Wilson W D; Mokrosz J L; Strekowska A; Koziol A E; Palenik G J
A non-classical intercalation model for a bleomycin amplifier.
Anti-cancer drug design 1988;2(4):387-98.
1988: Scott E V; Jones R L; Banville D L; Zon G; Marzilli L G; Wilson W D
1H and 31P NMR investigations of actinomycin D binding selectivity with oligodeoxyribonucleotides containing multiple adjacent d(GC) sites.
Biochemistry 1988;27(3):915-23.
1987: Strekowski L; Watson R A; Wilson W D
Selective catalysis of A.T base pair proton exchange in DNA complexes: imino proton NMR analysis.
Nucleic acids research 1987;15(20):8511-9.
1987: Wilson W D; Chandrasekaran S; Kusuma S; Boykin D W; Neidle S
The influence of intercalator structure on DNA binding strength: the importance of side chain orientation.
Journal of biomolecular structure & dynamics 1987;5(2):327-44.
1987: Hopkins H P; Wilson W D
Enthalpy and entropy changes for the intercalation of small molecules to DNA. II. Ethidium and propidium fluoride.
Biopolymers 1987;26(8):1347-55.
1987: Strekowski L; Strekowska A; Watson R A; Tanious F A; Nguyen L T; Wilson W D
Amplification of bleomycin-mediated degradation of DNA.
Journal of medicinal chemistry 1987;30(8):1415-20.
1987: Bower M; Summers M F; Powell C; Shinozuka K; Regan J B; Zon G; Wilson W D
Oligodeoxyribonucleoside methylphosphonates. NMR and UV spectroscopic studies of Rp-Rp and Sp-Sp methylphosphonate (Me) modified duplexes of (d[GGAATTCC])2.
Nucleic acids research 1987;15(12):4915-30.
1987: Bower M; Summers M F; Kell B; Hoskins J; Zon G; Wilson W D
Synthesis and characterization of oligodeoxyribonucleotides containing terminal phosphates. NMR, UV spectroscopic and thermodynamic analysis of duplex formation of [d(pGGAATTCC)]2, [d(GGAATTCCp)]2 and [d(pGGAATTCCp)]2.
Nucleic acids research 1987;15(8):3531-47.
1987: Wilson W D; Zuo E T; Jones R L; Zon G L; Baumstark B R
Sequence dependent electrophoretic mobilities and melting temperatures for A-T containing oligodeoxyribonucleotides.
Nucleic acids research 1987;15(1):105-18.
1987: Wilson W D
Cooperative effects in drug-DNA interactions.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 1987;31():193-221.
1986: Jones R L; Zon G; Krishnamoorthy C R; Wilson W D
Sequence-dependent cooperative interactions in A/T-containing oligo- and polydeoxyribonucleotides.
Biochemistry 1986;25(23):7431-9.
1986: Banville D L; Marzilli L G; Wilson W D
NMR investigation of DNA conformational changes on base protonation: use of Cu2+ and pyrazole as probes.
Biochemistry 1986;25(23):7393-401.
1986: LaPlanche L A; James T L; Powell C; Wilson W D; Uznanski B; Stec W J; Summers M F; Zon G
Phosphorothioate-modified oligodeoxyribonucleotides. III. NMR and UV spectroscopic studies of the Rp-Rp, Sp-Sp, and Rp-Sp duplexes, [d(GGSAATTCC)]2, derived from diastereomeric O-ethyl phosphorothioates.
Nucleic acids research 1986;14(22):9081-93.
1986: Krishnamoorthy C R; Yen S F; Smith J C; Lown J W; Wilson W D
Stopped-flow kinetic analysis of the interaction of anthraquinone anticancer drugs with calf thymus DNA, poly[d(G-C)].poly[d(G-C)], and poly[d(A-T)].poly[d(A-T)].
Biochemistry 1986;25(20):5933-40.
1986: Wilson W D; Jones R L; Zon G; Banville D L; Marzilli L G
Specificity in DNA interactions: an nmr investigation of the interaction of propidium with oligodeoxyribonucleotides containing normal and G-T base pairs.
Biopolymers 1986;25(10):1997-2015.
1986: Banville D L; Marzilli L G; Strickland J A; Wilson W D
Comparison of the effects of cationic porphyrins on DNA properties: influence of GC content of native and synthetic polymers.
Biopolymers 1986;25(10):1837-58.
1986: Summers M F; Powell C; Egan W; Byrd R A; Wilson W D; Zon G
Alkyl phosphotriester modified oligodeoxyribonucleotides. VI. NMR and UV spectroscopic studies of ethyl phosphotriester (Et) modified Rp-Rp and Sp-Sp duplexes, (d[GGAA(Et)TTCC])2.
Nucleic acids research 1986;14(18):7421-36.
1986: Wilson W D; Wang Y H; Kusuma S; Chandrasekaran S; Boykin D W
The effect of intercalator structure on binding strength and base-pair specificity in DNA interactions.
Biophysical chemistry 1986;24(2):101-9.
1986: Strekowski L; Chandrasekaran S; Wang Y H; Edwards W D; Wilson W D
Molecular basis for anticancer drug amplification: interaction of phleomycin amplifiers with DNA.
Journal of medicinal chemistry 1986;29(7):1311-5.
1986: Wilson W D; Wang Y H; Krishnamoorthy C R; Smith J C
Intercalators as probes of DNA conformation: propidium binding to alternating and non-alternating polymers containing guanine.
Chemico-biological interactions 1986;58(1):41-56.
1985: McMurray C T; van Holde K E; Jones R L; Wilson W D
Proton NMR investigation of the nucleosome core particle: evidence for regions of altered hydrogen bonding.
Biochemistry 1985;24(25):7037-44.
1985: Chandrasekaran S; Jones R L; Wilson W D
Imino 1H- and 31P-NMR analysis of the interaction of propidium and ethidium with DNA.
Biopolymers 1985;24(10):1963-79.
1985: Wilson W D; Krishnamoorthy C R; Wang Y H; Smith J C
Mechanism of intercalation: ion effects on the equilibrium and kinetic constants for the interaction of propidium and ethidium with DNA.
Biopolymers 1985;24(10):1941-61.
1985: Lown J W; Morgan A R; Yen S F; Wang Y H; Wilson W D
Characteristics of the binding of the anticancer agents mitoxantrone and ametantrone and related structures to deoxyribonucleic acids.
Biochemistry 1985;24(15):4028-35.
1985: Wilson W D; Wang Y H; Krishnamoorthy C R; Smith J C
Poly(dA).poly(dT) exists in an unusual conformation under physiological conditions: propidium binding to poly(dA).poly(dT) and poly[d(A-T)].poly[d(A-T)].
Biochemistry 1985;24(15):3991-9.
1985: Kitchen S E; Wang Y H; Baumstark A L; Wilson W D; Boykin D W
The intercalation of 6-chloro-substituted-9-[[3-(dimethylamino)propyl]amino]acridines with DNA.
Journal of medicinal chemistry 1985;28(7):940-4.
1984: Stevenson K A; Yen S F; Yang N C; Boykin D W; Wilson W D
A substituent constant analysis of the interaction of substituted naphthalene monoimides with DNA.
Journal of medicinal chemistry 1984;27(12):1677-82.
1984: Yen S F; Wilson W D; Pearce S W; Gabbay E J
A new series of reductive amination derivatives of daunorubicin: syntheses, partition coefficients, and DNA binding.
Journal of pharmaceutical sciences 1984;73(11):1575-9.
1984: Marzilli L G; Reily M D; Heyl B L; McMurray C T; Wilson W D
Evidence for similar structural changes on binding of platinum anti-tumor agents to DNA and nucleosomes.
FEBS letters 1984;176(2):389-92.
1984: Chandrasekaran S; Krishnamoorthy C R; Jones R L; Smith J C; Wilson W D
Stopped-flow kinetic, 1H, and 31P NMR analysis of the intercalation of ethidium with poly d(G-C) X d(G-C).
Biochemical and biophysical research communications 1984;122(2):804-9.
1983: Banville D L; Marzilli L G; Wilson W D
31P NMR and viscometric studies of the interaction of meso-tetra(4-N-methylpyridyl) porphine and its Ni(II) and Zn(II) derivatives with DNA.
Biochemical and biophysical research communications 1983;113(1):148-54.
1982: King H D; Wilson W D; Gabbay E J
Interactions of some novel amide-linked bis(acridines) with deoxyribonucleic acid.
Biochemistry 1982;21(20):4982-9.
1982: Wilson W D; Keel R A; Jones R L; Mosher C W
Viscometric analysis of the interaction of bisphenanthridinium compounds with closed circular supercoiled and linear DNA.
Nucleic acids research 1982;10(13):4093-106.
1982: Yen S F; Gabbay E J; Wilson W D
Interaction of aromatic imides with deoxyribonucleic acid. Spectrophotometric and viscometric studies.
Biochemistry 1982;21(9):2070-6.
1982: Wilson W D; Jones R L
Interaction of actinomycin D, ethidium, quinacrine, daunorubicin, and tetralysine with DNA: 31P NMR chemical shift and relaxation investigation.
Nucleic acids research 1982;10(4):1399-410.
1981: Jones R L; Wilson W D
Effect of ionic strength on the pKa of ligands bound to DNA.
Biopolymers 1981;20(1):141-54.
1981: Wilson W D; Jones R L
Intercalating drugs: DNA binding and molecular pharmacology.
Advances in pharmacology and chemotherapy 1981;18():177-222.
1980: Jones R L; Lanier A C; Keel R A; Wilson W D
The effect of ionic strength on DNA-ligand unwinding angles for acridine and quinoline derivatives.
Nucleic acids research 1980;8(7):1613-24.
1979: Gough A N; Jones R L; Wilson W D
Dimerization of coralyne and its propyl analogue and their association with DNA.
Journal of medicinal chemistry 1979;22(12):1551-4.
1979: Wilson W D; Lopp I G
Analysis of cooperativity and ion effects in the interaction of quinacrine with DNA.
Biopolymers 1979;18(12):3025-41.
1979: Mariam Y H; Wilson W D
A 31P NMR analysis of the helix to coil transition of natural DNA samples: evidence for the existence of different conformational states.
Biochemical and biophysical research communications 1979;88(3):861-6.
1979: Jones R L; Davidson M W; Wilson W D
Comparative viscometric analysis of the interaction of chloroquine and quinacrine with superhelical and sonicated DNA.
Biochimica et biophysica acta 1979;561(1):77-84.
1978: Davidson M W; Griggs B G; Lopp I G; Boykin D W; Wilson W D
Nuclear magnetic resonance investigation of the interaction of a 13C-labeled quinacrine derivative with DNA.
Biochemistry 1978;17(20):4220-5.
1978: Gabbay E J; Wilson W D
Intercalating agents as probes of chromatin structure.
Methods in cell biology 1978;18():351-84.
1977: Davidson M W; Griggs B G; Lopp I G; Wilson W D
The interaction of propidium diiodide with self-complementary dinucleoside monophosphates.
Biochimica et biophysica acta 1977;479(4):378-90.
1977: Davidson M W; Griggs B G; Boykin D W; Wilson W D
Molecular structural effects involved in the interaction of quinolinemethanolamines with DNA. Implications for antimalarial action.
Journal of medicinal chemistry 1977;20(9):1117-22.
1977: Davidson M W; Lopp I; Alexander S; Wilson W D
The interaction of plant alkaloids with DNA. II. Berberinium chloride.
Nucleic acids research 1977;4(8):2697-712.
1976: Wilson W D; Gough A N; Doyle J J; Davidson M W
Coralyne. Intercalation with DNA as a possible mechanism of antileukemic action.
Journal of medicinal chemistry 1976;19(10):1261-3.
1976: Gabbay E J; Grier D; Fingerle R E; Reimer R; Levy R; Pearce S W; Wilson W D
Interaction specificity of the anthracyclines with deoxyribonucleic acid.
Biochemistry 1976;15(10):2062-70.
1976: Wilson D W; Grier D; Reimer R; Bauman J D; Preston J F; Gabbay E J
Sturcture-activity relationship of daunorubicin and its peptide derivatives.
Journal of medicinal chemistry 1976;19(3):381-4.
1976: Gabbay E J; Adawadkar P D; Kapicak L; Pearce S; Wilson W D
The interaction specificity of peptides with DNA. Evidence for peptide beta-sheet-DNA binding.
Biochemistry 1976;15(1):152-7.
1976: Gabbay E J; Adawadkar P D; Wilson W D
Stereospecific binding of diastereomeric peptides to salmon sperm DNA.
Biochemistry 1976;15(1):146-51.
1975: Davidson M W; Wilson W D
Strand polarity: antiparallel molecular interactions in nucleic acids.
Journal of chemical education 1975;52(5):323-4.
1975: Adawadkar P; Wilson W D; Brey W; Gabbay E J
Letter: Stereospecific interaction of dipeptide amides with DNA. Evidence for partial intercalation and bending of the helix.
Journal of the American Chemical Society 1975;97(7):1959-61.
1975: Davidson M W; Griggs B G; Boykin D W; Wilson W D
Mefloquine, a clinically useful quinolinemethanol antimalarial which does not significantly bind to DNA.
Nature 1975;254(5501):632-4.
1975: Olmstead E J; Panter J W; Boykin D W; Wilson W D
Complex formation between naphthothiopheneethanolamines and deoxyribonucleic acids.
Biochemistry 1975;14(3):521-6.
1973: Panter J W; Boykin D W; Wilson W D
Effect of ring and side chain substituents on the binding of naphthothiopheneethanolamines to deoxyribonucleic acid. Spectrophotometric studies.
Journal of medicinal chemistry 1973;16(12):1366-9.
1972: Wilson W D; Foster J F
Photolysis accompanying peptide absorption in proteins. Electrophoresis and optical rotary dispersion studies.
Biophysical journal 1972;12(6):609-24.
1971: Wilson W D; Foster J F
Conformation-dependent limited proteolysis of bovine plasma albumin by an enzyme present in commercial albumin preparations.
Biochemistry 1971;10(10):1772-80.
1970: Wilson W D; Foster J F
Alterations in proteins and polyamino acids caused by ultraviolet irradiation in a spectropolarimeter.
Biochemical and biophysical research communications 1970;38(4):552-8.

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