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Fred Cohen

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Jay H Choi; Cedric Govaerts; Barnaby C H May; Fred Cohen
Analysis of the sequence and structural features of the left-handed beta-helical fold.
Gültekin Tamgüney; Kurt Giles; David V Glidden; Pierre Lessard; Holger Wille; Patrick Tremblay; Darlene F Groth; Fruma Yehiely; Carsten Korth; Richard C Moore; Jörg Tatzelt; Eric Rubinstein; Claude Boucheix; Xiaoping Yang; Pamela Stanley; Michael P Lisanti; Raymond A Dwek; Pauline M Rudd; Jackob Moskovitz; Charles J Epstein; Tracey Dawson Cruz; William Kuziel; Nobuyo Maeda; Jan Sap; Karen K. Hsiao Ashe; George A Carlson; Ina C. Tesseur; Tony Wyss-Coray; Lennart Mucke; Karl H Weisgraber; Robert W Mahley; Fred Cohen; Stanley B Prusiner
Genes contributing to prion pathogenesis.
Holger Wille; Cedric Govaerts; Alexander Borovinskiy; Diane Latawiec; Kenneth H Downing; Fred Cohen; Stanley B Prusiner
Electron crystallography of the scrapie prion protein complexed with heavy metals.

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All Publications

2008: Jay H Choi; Cedric Govaerts; Barnaby C H May; Fred Cohen
Analysis of the sequence and structural features of the left-handed beta-helical fold.
Proteins 2008;73(1):150-60.
2008: Gültekin Tamgüney; Kurt Giles; David V Glidden; Pierre Lessard; Holger Wille; Patrick Tremblay; Darlene F Groth; Fruma Yehiely; Carsten Korth; Richard C Moore; Jörg Tatzelt; Eric Rubinstein; Claude Boucheix; Xiaoping Yang; Pamela Stanley; Michael P Lisanti; Raymond A Dwek; Pauline M Rudd; Jackob Moskovitz; Charles J Epstein; Tracey Dawson Cruz; William Kuziel; Nobuyo Maeda; Jan Sap; Karen K. Hsiao Ashe; George A Carlson; Ina C. Tesseur; Tony Wyss-Coray; Lennart Mucke; Karl H Weisgraber; Robert W Mahley; Fred Cohen; Stanley B Prusiner
Genes contributing to prion pathogenesis.
The Journal of general virology 2008;89(Pt 7):1777-88.
2007: Holger Wille; Cedric Govaerts; Alexander Borovinskiy; Diane Latawiec; Kenneth H Downing; Fred Cohen; Stanley B Prusiner
Electron crystallography of the scrapie prion protein complexed with heavy metals.
Archives of biochemistry and biophysics 2007;467(2):239-48.
2007: Sina Ghaemmaghami; Puay-Wah Phuan; Beth Perkins; Julie Ullman; Barnaby C H May; Fred Cohen; Stanley B Prusiner
Cell division modulates prion accumulation in cultured cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(46):17971-6.
2007: Conor R Caffrey; Dietmar Steverding; Ryan K Swenerton; Ben Kelly; Deirdre Walshe; Anjan Debnath; Yuan-Min Zhou; Patricia S Doyle; Aaron T Fafarman; Julie A Zorn; Kirkwood M Land; Jessica Beauchene; Kimberly Schreiber; Heidrun Moll; Alicia Ponte-Sucre; Tanja Schirmeister; Ahilan Saravanamuthu; Alan H Fairlamb; Fred Cohen; James H McKerrow; Jennifer L Weisman; Barnaby C H May
Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.
Antimicrobial agents and chemotherapy 2007;51(6):2164-72.
2007: Puay-Wah Phuan; Julie A Zorn; Jiri G Safar; Kurt Giles; Stanley B Prusiner; Fred Cohen; Barnaby C H May
Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds.
The Journal of general virology 2007;88(Pt 4):1392-401.
2007: Lawrence C Lee; Florence Horn; Fred Cohen
Automatic extraction of protein point mutations using a graph bigram association.
PLoS computational biology 2007;3(2):e16.
2007: Barnaby C H May; Julie A Zorn; Juanita Witkop; John Sherrill; Andrew C Wallace; Giuseppe Legname; Stanley B Prusiner; Fred Cohen
Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.
Journal of medicinal chemistry 2007;50(1):65-73.
2006: Giuseppe Legname; Hoang-Oanh B Nguyen; David Peretz; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner
Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19105-10.
2006: Béatrice Luginbühl; Zoltan F Kanyo; R Mark Jones; Robert J Fletterick; Stanley B Prusiner; Fred Cohen; R Anthony Williamson; Dennis R Burton; Andreas Plückthun
Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation.
Journal of molecular biology 2006;363(1):75-97.
2006: Barnaby C H May; Juanita Witkop; John Sherrill; Marc O Anderson; Peter B Madrid; Julie A Zorn; Stanley B Prusiner; Fred Cohen; R Kiplin Guy
Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.
Bioorganic & medicinal chemistry letters 2006;16(18):4913-6.
2006: Jennifer L Weisman; Ally P Liou; Anang A Shelat; Fred Cohen; R Kiplin Guy; Joe L DeRisi
Searching for new antimalarial therapeutics amongst known drugs.
Chemical biology & drug design 2006;67(6):409-16.
2006: Barnaby C H May; Cedric Govaerts; Fred Cohen
Developing therapeutics for the diseases of protein misfolding.
Neurology 2006;66(2 Suppl 1):S118-22.
2005: Shiming Ye; Yadong Huang; Karin Müllendorff; Liming Dong; Gretchen Giedt; Elaine C Meng; Fred Cohen; Irwin D Kuntz; Karl H Weisgraber; Robert W Mahley
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18700-5.
2005: Giuseppe Legname; Hoang-Oanh B Nguyen; Ilia Baskakov; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner
Strain-specified characteristics of mouse synthetic prions.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2168-73.
2004: Giuseppe Legname; Ilia Baskakov; Hoang-Oanh B Nguyen; Detlev Riesner; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner
Synthetic mammalian prions.
Science (New York, N.Y.) 2004;305(5684):673-6.
2004: Cedric Govaerts; Holger Wille; Stanley B Prusiner; Fred Cohen
Evidence for assembly of prions with left-handed beta-helices into trimers.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(22):8342-7.
2004: Gerold Schmitt-Ulms; Kirk Hansen; Jialing Liu; Cynthia Cowdrey; Jian Yang; Stephen J DeArmond; Fred Cohen; Stanley B Prusiner; Michael A Baldwin
Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.
Nature biotechnology 2004;22(6):724-31.
2004: Barnaby C H May; Cedric Govaerts; Stanley B Prusiner; Fred Cohen
Prions: so many fibers, so little infectivity.
Trends in biochemical sciences 2004;29(4):162-5.
2004: Florence Horn; Anthony L Lau; Fred Cohen
Automated extraction of mutation data from the literature: application of MuteXt to G protein-coupled receptors and nuclear hormone receptors.
Bioinformatics (Oxford, England) 2004;20(4):557-68.
2004: Patrick Tremblay; Haydn L Ball; Kiyotoshi Kaneko; Darlene Groth; Ramanujan S Hegde; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner; Jiri G Safar
Mutant PrPSc conformers induced by a synthetic peptide and several prion strains.
Journal of virology 2004;78(4):2088-99.
2003: Fred Cohen; Jeffery W Kelly
Therapeutic approaches to protein-misfolding diseases.
Nature 2003;426(6968):905-9.
2003: John-Marc Chandonia; Fred Cohen
New local potential useful for genome annotation and 3D modeling.
Journal of molecular biology 2003;332(4):835-50.
2003: Barnaby C H May; Aaron T Fafarman; Septima B Hong; Michael Rogers; Leslie W Deady; Stanley B Prusiner; Fred Cohen
Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3416-21.
2003: Zbynek Bozdech; Jingchun Zhu; marcin joachimiak; Fred Cohen; Brian Pulliam; Joe L DeRisi
Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray.
Genome biology 2003;4(2):R9.
2003: Alessandra Devoto; H Andreas Hartmann; Pietro Piffanelli; Candace Elliott; Carl Simmons; Graziana Taramino; Chern-Sing Goh; Fred Cohen; Brent C Emerson; Paul Schulze-Lefert; Ralph Panstruga
Molecular phylogeny and evolution of the plant-specific seven-transmembrane MLO family.
Journal of molecular evolution 2003;56(1):77-88.
2003: Florence Horn; Emmanuel Bettler; Laerte Oliveira; Fabien Campagne; Fred Cohen; Gert Vriend
GPCRDB information system for G protein-coupled receptors.
Nucleic acids research 2003;31(1):294-7.
2002: Chern-Sing Goh; Fred Cohen
Co-evolutionary analysis reveals insights into protein-protein interactions.
Journal of molecular biology 2002;324(1):177-92.
2002: Véronique Perrier; Kiyotoshi Kaneko; Jiri G Safar; Julie Vergara; Patrick Tremblay; Stephen J DeArmond; Fred Cohen; Stanley B Prusiner; Andrew C Wallace
Dominant-negative inhibition of prion replication in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13079-84.
2002: Xiaohui Du; Chun Guo; Elizabeth Hansell; Patricia S Doyle; Conor R Caffrey; Tod P Holler; James H McKerrow; Fred Cohen
Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.
Journal of medicinal chemistry 2002;45(13):2695-707.
2002: Ilia Baskakov; Giuseppe Legname; Michael A Baldwin; Stanley B Prusiner; Fred Cohen
Pathway complexity of prion protein assembly into amyloid.
The Journal of biological chemistry 2002;277(24):21140-8.
2002: Carlos R Rodrigues; Terrence M Flaherty; Clayton Springer; James H McKerrow; Fred Cohen
CoMFA and HQSAR of acylhydrazide cruzain inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(11):1537-41.
2002: Timothy S Burkoth; Eric Beausoleil; Surinder Kaur; Dahzi Tang; Fred Cohen; Ronald N Zuckermann
Toward the synthesis of artificial proteins: the discovery of an amphiphilic helical peptoid assembly.
Chemistry & biology 2002;9(5):647-54.
2002: Holger Wille; Melissa D Michelitsch; Vincent Guenebaut; Surachai Supattapone; Ana Serban; Fred Cohen; David A Agard; Stanley B Prusiner
Structural studies of the scrapie prion protein by electron crystallography.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3563-8.
2002: Conor R Caffrey; Marvin Schanz; njinkeng nkemngu; Joseph Nkemgu-Njinkeng; Matthew Brush; Elizabeth Hansell; Fred Cohen; Terrence M Flaherty; James H McKerrow; Dietmar Steverding
Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei.
International journal of antimicrobial agents 2002;19(3):227-31.
2002: Eric M Nicholson; Huaping Mo; Stanley B Prusiner; Fred Cohen; Susan Marqusee
Differences between the prion protein and its homolog Doppel: a partially structured state with implications for scrapie formation.
Journal of molecular biology 2002;316(3):807-15.
2002: Mitchell A Avery; Maria Alvim-Gaston; Carlos R Rodrigues; Eliezer J Barreiro; Fred Cohen; Yogesh A Sabnis; John R Woolfrey
Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies.
Journal of medicinal chemistry 2002;45(2):292-303.
2002: marcin joachimiak; Fred Cohen
JEvTrace: refinement and variations of the evolutionary trace in JAVA.
Genome biology 2002;3(12):RESEARCH0077.
2002: Patrick S Beisser; C S Goh; Fred Cohen; Susan Michelson
Viral chemokine receptors and chemokines in human cytomegalovirus trafficking and interaction with the immune system. CMV chemokine receptors.
Current topics in microbiology and immunology 2002;269():203-34.
2001: Gerold Schmitt-Ulms; Giuseppe Legname; Michael A Baldwin; Haydn L Ball; N Bradon; Patrick Bosque; Kathryn L Crossin; Gerald M Edelman; Stephen J DeArmond; Fred Cohen; Stanley B Prusiner
Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein.
Journal of molecular biology 2001;314(5):1209-25.
2001: Haydn L Ball; D S King; Fred Cohen; Stanley B Prusiner; Michael A Baldwin
Engineering the prion protein using chemical synthesis.
The journal of peptide research : official journal of the American Peptide Society 2001;58(5):357-74.
2001: marcin joachimiak; C Chang; P J Rosenthal; Fred Cohen
The impact of whole genome sequence data on drug discovery--a malaria case study.
Molecular medicine (Cambridge, Mass.) 2001;7(10):698-710.
2001: David D Laws; Hans-Marcus L Bitter; K Liu; Haydn L Ball; Kiyotoshi Kaneko; Holger Wille; Fred Cohen; Stanley B Prusiner; Alexander Pines; David E Wemmer
Solid-state NMR studies of the secondary structure of a mutant prion protein fragment of 55 residues that induces neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11686-90.
2001: Carsten Korth; Barnaby C H May; Fred Cohen; Stanley B Prusiner
Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9836-41.
2001: Yoichi Matsunaga; David Peretz; A Williamson; D Burton; IR Mehlhorn; Darlene Groth; Fred Cohen; Stanley B Prusiner; Michael A Baldwin
Cryptic epitopes in N-terminally truncated prion protein are exposed in the full-length molecule: dependence of conformation on pH.
Proteins 2001;44(2):110-8.
2001: Ilia Baskakov; Giuseppe Legname; Stanley B Prusiner; Fred Cohen
Folding of prion protein to its native alpha-helical conformation is under kinetic control.
The Journal of biological chemistry 2001;276(23):19687-90.
2001: David Peretz; Michael R Scott; Darlene Groth; R Anthony Williamson; Dennis R Burton; Fred Cohen; Stanley B Prusiner
Strain-specified relative conformational stability of the scrapie prion protein.
Protein science : a publication of the Protein Society 2001;10(4):854-63.
2001: P M Harrison; H S Chan; Stanley B Prusiner; Fred Cohen
Conformational propagation with prion-like characteristics in a simple model of protein folding.
Protein science : a publication of the Protein Society 2001;10(4):819-35.
2001: Surachai Supattapone; Essia Bouzamondo; Haydn L Ball; Holger Wille; Hoang-Oanh B Nguyen; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner; Michael Scott
A protease-resistant 61-residue prion peptide causes neurodegeneration in transgenic mice.
Molecular and cellular biology 2001;21(7):2608-16.
2001: Surachai Supattapone; Holger Wille; LS Uyechi; Jiri G Safar; Patrick Tremblay; Francis C Szoka; Fred Cohen; Stanley B Prusiner; Michael R Scott
Branched polyamines cure prion-infected neuroblastoma cells.
Journal of virology 2001;75(7):3453-61.
2001: J D Blake; Fred Cohen
Pairwise sequence alignment below the twilight zone.
Journal of molecular biology 2001;307(2):721-35.
2001: Darwin O V Alonso; S J DeArmond; Fred Cohen; Valerie Daggett
Mapping the early steps in the pH-induced conformational conversion of the prion protein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):2985-9.
2001: JH Viles; DG Donne; Gerard Kroon; Stanley B Prusiner; Fred Cohen; H Jane Dyson; Peter Wright
Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics.
Biochemistry 2001;40(9):2743-53.
2001: H Mo; Richard C Moore; Fred Cohen; David Westaway; Stanley B Prusiner; Peter Wright; H Jane Dyson
Two different neurodegenerative diseases caused by proteins with similar structures.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2352-7.
2001: Surachai Supattapone; T Muramoto; Giuseppe Legname; IR Mehlhorn; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner; Michael R Scott
Identification of two prion protein regions that modify scrapie incubation time.
Journal of virology 2001;75(3):1408-13.
2001: Florence Horn; Gert Vriend; Fred Cohen
Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems.
Nucleic acids research 2001;29(1):346-9.
2000: Surachai Supattapone; Hoang-Oanh B Nguyen; T Muramoto; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner; Michael Scott
Affinity-tagged miniprion derivatives spontaneously adopt protease-resistant conformations.
Journal of virology 2000;74(24):11928-34.
2000: Eliah Aronoff-Spencer; Colin S Burns; Nikolai I Avdievich; Gary J Gerfen; Jack Peisach; William E Antholine; H L Ball; Fred Cohen; Stanley B Prusiner; Glenn L Millhauser
Identification of the Cu2+ binding sites in the N-terminal domain of the prion protein by EPR and CD spectroscopy.
Biochemistry 2000;39(45):13760-71.
2000: AA Bogan; Q Dallas-Yang; Michael D Ruse; Y Maeda; G Jiang; L Nepomuceno; Thomas S Scanlan; Fred Cohen; Frances M Sladek
Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha.
Journal of molecular biology 2000;302(4):831-51.
2000: X Du; Elizabeth Hansell; Juan C Engel; Conor R Caffrey; Fred Cohen; James H McKerrow
Aryl ureas represent a new class of anti-trypanosomal agents.
Chemistry & biology 2000;7(9):733-42.
2000: GL Silverman; Kefeng Qin; Richard C Moore; Ying Yang; Peter Mastrangelo; Patrick Tremblay; Stanley B Prusiner; Fred Cohen; David Westaway
Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss.
The Journal of biological chemistry 2000;275(35):26834-41.
2000: L Troeberg; X Chen; Terrence M Flaherty; Rory Morty; M Cheng; H Hua; C Springer; James H McKerrow; G L Kenyon; John Lonsdale-Eccles; Theresa H T Coetzer; Fred Cohen
Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei.
Molecular medicine (Cambridge, Mass.) 2000;6(8):660-9.
2000: Fred Cohen
Prions, peptides and protein misfolding.
Molecular medicine today 2000;6(7):292-3.
2000: Chern-Sing Goh; AA Bogan; marcin joachimiak; Dirk Walther; Fred Cohen
Co-evolution of proteins with their interaction partners.
Journal of molecular biology 2000;299(2):283-93.
2000: Holger Wille; Stanley B Prusiner; Fred Cohen
Scrapie infectivity is independent of amyloid staining properties of the N-terminally truncated prion protein.
Journal of structural biology 2000;130(2-3):323-38.
2000: V Perrier; Andrew C Wallace; Kiyotoshi Kaneko; Jiri G Safar; Stanley B Prusiner; Fred Cohen
Mimicking dominant negative inhibition of prion replication through structure-based drug design.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):6073-8.
2000: L Zulianello; Kiyotoshi Kaneko; Michael Scott; S Erpel; D Han; Fred Cohen; Stanley B Prusiner
Dominant-negative inhibition of prion formation diminished by deletion mutagenesis of the prion protein.
Journal of virology 2000;74(9):4351-60.
2000: Ilia Baskakov; C Aagaard; IR Mehlhorn; Holger Wille; Darlene Groth; Michael A Baldwin; Stanley B Prusiner; Fred Cohen
Self-assembly of recombinant prion protein of 106 residues.
Biochemistry 2000;39(10):2792-804.
2000: Randy M Whittal; Haydn L Ball; Fred Cohen; Al L Burlingame; Stanley B Prusiner; Michael A Baldwin
Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry.
Protein science : a publication of the Protein Society 2000;9(2):332-43.
2000: Kiyotoshi Kaneko; Haydn L Ball; Holger Wille; Hui Zhang; Darlene Groth; M Torchia; Patrick Tremblay; Jiri G Safar; Stanley B Prusiner; Stephen J DeArmond; Michael A Baldwin; Fred Cohen
A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice.
Journal of molecular biology 2000;295(4):997-1007.
2000: Jiri G Safar; Fred Cohen; Stanley B Prusiner
Quantitative traits of prion strains are enciphered in the conformation of the prion protein.
Archives of virology. Supplementum 2000;(16):227-35.
1999: Surachai Supattapone; Hoang-Oanh B Nguyen; Fred Cohen; Stanley B Prusiner; Michael R Scott
Elimination of prions by branched polyamines and implications for therapeutics.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(25):14529-34.
1999: Zoltan F Kanyo; K M Pan; R Anthony Williamson; Dennis R Burton; Stanley B Prusiner; Robert J Fletterick; Fred Cohen
Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change.
Journal of molecular biology 1999;293(4):855-63.
1999: Fred Cohen
Protein misfolding and prion diseases.
Journal of molecular biology 1999;293(2):313-20.
1999: Richard C Moore; I Y Lee; GL Silverman; P M Harrison; R Strome; Cornelia Heinrich; A Karunaratne; Stephen Pasternak; M Azhar Chishti; Y Liang; Peter Mastrangelo; Kai Wang; A F Smit; S Katamine; G A Carlson; Fred Cohen; Stanley B Prusiner; David W Melton; Patrick Tremblay; L E Hood; David Westaway
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.
Journal of molecular biology 1999;292(4):797-817.
1999: H Liu; Shauna Farr-Jones; Nikolai B Ulyanov; M Llinas; Susan Marqusee; Darlene Groth; Fred Cohen; Stanley B Prusiner; Tom L James
Solution structure of Syrian hamster prion protein rPrP(90-231).
Biochemistry 1999;38(17):5362-77.
1999: H L Schwartz; J M Chandonia; SF Kash; Jamil Kanaani; E Tunnell; A Domingo; Fred Cohen; J Paul Banga; Anne-Marie Madec; W Richter; Steinunn Baekkeskov
High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase.
Journal of molecular biology 1999;287(5):983-99.
1999: Surachai Supattapone; Patrick Bosque; T Muramoto; Holger Wille; C Aagaard; David Peretz; Hoang-Oanh B Nguyen; Cornelia Heinrich; M Torchia; Jiri G Safar; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner; Michael Scott
Prion protein of 106 residues creates an artifical transmission barrier for prion replication in transgenic mice.
Cell 1999;96(6):869-78.
1999: J H Viles; Fred Cohen; Stanley B Prusiner; D B Goodin; Peter Wright; H J Dyson
Copper binding to the prion protein: structural implications of four identical cooperative binding sites.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2042-7.
1999: P M Harrison; H S Chan; Stanley B Prusiner; Fred Cohen
Thermodynamics of model prions and its implications for the problem of prion protein folding.
Journal of molecular biology 1999;286(2):593-606.
1999: Dirk Walther; Fred Cohen
Conformational attractors on the Ramachandran map.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 2):506-17.
1999: Dietlind L. Gerloff; Gina Cannarozzi; marcin joachimiak; Fred Cohen; D Schreiber; SA Benner
Evolutionary, mechanistic, and predictive analyses of the hydroxymethyldihydropterin pyrophosphokinase family of proteins.
Biochemical and biophysical research communications 1999;254(1):70-6.
1998: JT Nguyen; C W Turck; Fred Cohen; Ronald N Zuckermann; Wendell A Lim
Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors.
Science (New York, N.Y.) 1998;282(5396):2088-92.
1998: Dirk Walther; C Springer; Fred Cohen
Helix-helix packing angle preferences for finite helix axes.
Proteins 1998;33(4):457-9.
1998: Dietlind L. Gerloff; marcin joachimiak; Fred Cohen; Gina Cannarozzi; Stephen G Chamberlin; SA Benner
Structure prediction in a post-genomic environment: a secondary and tertiary structural model for the initiation factor 5A family.
Biochemical and biophysical research communications 1998;251(1):173-81.
1998: Jiri G Safar; Holger Wille; V Itri; Darlene Groth; Hana Serban; M Torchia; Fred Cohen; Stanley B Prusiner
Eight prion strains have PrP(Sc) molecules with different conformations.
Nature medicine 1998;4(10):1157-65.
1998: Michael A Baldwin; Tom L James; Fred Cohen; Stanley B Prusiner
The three-dimensional structure of prion protein: implications for prion disease.
Biochemical Society transactions 1998;26(3):481-6.
1998: AA Bogan; Fred Cohen; Thomas S Scanlan
Natural ligands of nuclear receptors have conserved volumes.
Nature structural biology 1998;5(8):679-81.
1998: C Y Huang; T Uno; JE Murphy; S Lee; J D Hamer; Jaime A Escobedo; Fred Cohen; R Radhakrishnan; VJ Dwarki; Ronald N Zuckermann
Lipitoids--novel cationic lipids for cellular delivery of plasmid DNA in vitro.
Chemistry & biology 1998;5(6):345-54.
1998: J Stöckel; Jiri G Safar; Andrew C Wallace; Fred Cohen; Stanley B Prusiner
Prion protein selectively binds copper(II) ions.
Biochemistry 1998;37(20):7185-93.
1998: Stanley B Prusiner; Michael R Scott; Stephen J DeArmond; Fred Cohen
Prion protein biology.
Cell 1998;93(3):337-48.
1998: P Armand; Kent Kirshenbaum; R A Goldsmith; Shauna Farr-Jones; Annelise E Barron; K T Truong; Ken A Dill; D F Mierke; Fred Cohen; Ronald N Zuckermann; Erin K Bradley
NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4309-14.
1998: Kent Kirshenbaum; Annelise E Barron; R A Goldsmith; P Armand; Erin K Bradley; K T Truong; Ken A Dill; Fred Cohen; Ronald N Zuckermann
Sequence-specific polypeptoids: a diverse family of heteropolymers with stable secondary structure.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4303-8.
1998: JE Murphy; T Uno; J D Hamer; Fred Cohen; VJ Dwarki; Ronald N Zuckermann
A combinatorial approach to the discovery of efficient cationic peptoid reagents for gene delivery.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1517-22.
1998: Fred Cohen; Stanley B Prusiner
Pathologic conformations of prion proteins.
Annual review of biochemistry 1998;67():793-819.
1997: Michael R Scott; Jiri G Safar; Glenn C Telling; O Nguyen; Darlene Groth; M Torchia; R Koehler; Patrick Tremblay; Dirk Walther; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner
Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14279-84.
1997: DG Donne; JH Viles; Darlene Groth; IR Mehlhorn; Tom L James; Fred Cohen; Stanley B Prusiner; Peter Wright; H Jane Dyson
Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13452-7.
1997: Olivier Lichtarge; Keith R Yamamoto; Fred Cohen
Identification of functional surfaces of the zinc binding domains of intracellular receptors.
Journal of molecular biology 1997;274(3):325-37.
1997: Stephen J DeArmond; H Sánchez; F Yehiely; Y Qiu; A Ninchak-Casey; V Daggett; A P Camerino; J Cayetano; M Rogers; Darlene Groth; M Torchia; Patrick Tremblay; Michael R Scott; Fred Cohen; Stanley B Prusiner
Selective neuronal targeting in prion disease.
Neuron 1997;19(6):1337-48.
1997: PM Selzer; X Chen; VJ Chan; M Cheng; G L Kenyon; Irwin D Kuntz; Judy A Sakanari; Fred Cohen; James H McKerrow
Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors.
Experimental parasitology 1997;87(3):212-21.
1997: Carrie L Byington; Roland Dunbrack; Frank G Whitby; Fred Cohen; N Agabian
Entamoeba histolytica: computer-assisted modeling of phosphofructokinase for the prediction of broad-spectrum antiparasitic agents.
Experimental parasitology 1997;87(3):194-202.
1997: David Peretz; R Anthony Williamson; Yoichi Matsunaga; Hana Serban; Clemencia Pinilla; RB Bastidas; R Rozenshteyn; Tom L James; R A Houghten; Fred Cohen; Stanley B Prusiner; Dennis R Burton
A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform.
Journal of molecular biology 1997;273(3):614-22.
1997: Tom L James; H Liu; Nikolai B Ulyanov; Shauna Farr-Jones; Hui Zhang; DG Donne; Kiyotoshi Kaneko; Darlene Groth; IR Mehlhorn; Stanley B Prusiner; Fred Cohen
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10086-91.
1997: Kiyotoshi Kaneko; L Zulianello; M Scott; C M Cooper; Andrew C Wallace; Tom L James; Fred Cohen; Stanley B Prusiner
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10069-74.
1997: Roland Dunbrack; Fred Cohen
Bayesian statistical analysis of protein side-chain rotamer preferences.
Protein science : a publication of the Protein Society 1997;6(8):1661-81.
1997: Kiyotoshi Kaneko; Holger Wille; IR Mehlhorn; Hui Zhang; Haydn Ball; Fred Cohen; Michael A Baldwin; Stanley B Prusiner
Molecular properties of complexes formed between the prion protein and synthetic peptides.
Journal of molecular biology 1997;270(4):574-86.
1997: T Muramoto; Stephen J DeArmond; Michael Scott; Glenn C Telling; Fred Cohen; Stanley B Prusiner
Heritable disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an alpha-helix.
Nature medicine 1997;3(7):750-5.
1997: K M Lundberg; Chris Stenland; Fred Cohen; Stanley B Prusiner; Glenn L Millhauser
Kinetics and mechanism of amyloid formation by the prion protein H1 peptide as determined by time-dependent ESR.
Chemistry & biology 1997;4(5):345-55.
1997: M J Bower; Fred Cohen; Roland Dunbrack
Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: a new homology modeling tool.
Journal of molecular biology 1997;267(5):1268-82.
1997: Glenn C Telling; Patrick Tremblay; M Torchia; Stephen J DeArmond; Fred Cohen; Stanley B Prusiner
N-terminally tagged prion protein supports prion propagation in transgenic mice.
Protein science : a publication of the Protein Society 1997;6(4):825-33.
1997: Hui Zhang; J Stockel; IR Mehlhorn; Darlene Groth; Michael A Baldwin; Stanley B Prusiner; Tom L James; Fred Cohen
Physical studies of conformational plasticity in a recombinant prion protein.
Biochemistry 1997;36(12):3543-53.
1997: Kiyotoshi Kaneko; Martin Vey; M Scott; S Pilkuhn; Fred Cohen; Stanley B Prusiner
COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2333-8.
1997: Dietlind L. Gerloff; Fred Cohen; C Korostensky; Marcel Turcotte; Gaston H Gonnet; SA Benner
A predicted consensus structure for the N-terminal fragment of the heat shock protein HSP90 family.
Proteins 1997;27(3):450-8.
1997: Dietlind L. Gerloff; Fred Cohen; SA Benner
A predicted consensus structure for the C terminus of the beta and gamma chains of fibrinogen.
Proteins 1997;27(2):279-89.
1997: P M Harrison; P Bamborough; V Daggett; Stanley B Prusiner; Fred Cohen
The prion folding problem.
Current opinion in structural biology 1997;7(1):53-9.
1997: H M Schätzl; M Da Costa; L Taylor; Fred Cohen; Stanley B Prusiner
Prion protein gene variation among primates.
Journal of molecular biology 1997;265(2):257.
1997: P Armand; Kent Kirshenbaum; A Falicov; Roland Dunbrack; Ken A Dill; Ronald N Zuckermann; Fred Cohen
Chiral N-substituted glycines can form stable helical conformations.
Folding & design 1997;2(6):369-75.
1997: F Yehiely; P Bamborough; M Da Costa; B J Perry; Gopal Thinakaran; Fred Cohen; G A Carlson; Stanley B Prusiner
Identification of candidate proteins binding to prion protein.
Neurobiology of disease 1997;3(4):339-55.
1997: Roland Dunbrack; Dietlind L. Gerloff; M Bower; X Chen; Olivier Lichtarge; Fred Cohen
Meeting review: the Second meeting on the Critical Assessment of Techniques for Protein Structure Prediction (CASP2), Asilomar, California, December 13-16, 1996.
Folding & design 1997;2(2):R27-42.
1997: Carrie L Byington; Roland Dunbrack; Fred Cohen; N Agabian
Molecular modeling of phosphofructokinase from Entamoeba histolytica for the prediction of new antiparasitic agents.
Archives of medical research 1997;28 Spec No():86-8.
1996: T Muramoto; Michael Scott; Fred Cohen; Stanley B Prusiner
Recombinant scrapie-like prion protein of 106 amino acids is soluble.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(26):15457-62.
1996: T R Defay; Fred Cohen
Multiple sequence information for threading algorithms.
Journal of molecular biology 1996;262(2):314-23.
1996: R Li; X Chen; B Gong; P M Selzer; Z Li; E Davidson; G Kurzban; R E Miller; E O Nuzum; James H McKerrow; Robert J Fletterick; S A Gillmor; Charles S Craik; Irwin D Kuntz; Fred Cohen; G L Kenyon
Structure-based design of parasitic protease inhibitors.
Bioorganic & medicinal chemistry 1996;4(9):1421-7.
1996: Olivier Lichtarge; Henry R Bourne; Fred Cohen
Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7507-11.
1996: Holger Wille; G F Zhang; Michael A Baldwin; Fred Cohen; Stanley B Prusiner
Separation of scrapie prion infectivity from PrP amyloid polymers.
Journal of molecular biology 1996;259(4):608-21.
1996: A Falicov; Fred Cohen
A surface of minimum area metric for the structural comparison of proteins.
Journal of molecular biology 1996;258(5):871-92.
1996: Nancy E Lane; D B Kimmel; M H Nilsson; Fred Cohen; S Newton; Robert A Nissenson; G J Strewler
Bone-selective analogs of human PTH(1-34) increase bone formation in an ovariectomized rat model.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(5):614-25.
1996: IR Mehlhorn; Darlene Groth; J Stöckel; Barbara Moffat; D Reilly; D Yansura; W S Willett; M Baldwin; Robert J Fletterick; Fred Cohen; Richard Vandlen; D Henner; Stanley B Prusiner
High-level expression and characterization of a purified 142-residue polypeptide of the prion protein.
Biochemistry 1996;35(17):5528-37.
1996: P Bamborough; Fred Cohen
Modeling protein-ligand complexes.
Current opinion in structural biology 1996;6(2):236-41.
1996: Olivier Lichtarge; Henry R Bourne; Fred Cohen
An evolutionary trace method defines binding surfaces common to protein families.
Journal of molecular biology 1996;257(2):342-58.
1996: P Bamborough; Holger Wille; Glenn C Telling; F Yehiely; Stanley B Prusiner; Fred Cohen
Prion protein structure and scrapie replication: theoretical, spectroscopic, and genetic investigations.
Cold Spring Harbor symposia on quantitative biology 1996;61():495-509.
1996: R Cerpa; Fred Cohen; Irwin D Kuntz
Conformational switching in designed peptides: the helix/sheet transition.
Folding & design 1996;1(2):91-101.
1996: Z Huang; Stanley B Prusiner; Fred Cohen
Scrapie prions: a three-dimensional model of an infectious fragment.
Folding & design 1996;1(1):13-9.
1996: B Honig; Fred Cohen
Adding backbone to protein folding: why proteins are polypeptides.
Folding & design 1996;1(1):R17-20.
1996: Holger Wille; Michael A Baldwin; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner
Prion protein amyloid: separation of scrapie infectivity from PrP polymers.
Ciba Foundation symposium 1996;199():181-99; discussion 199-201.
1996: Dietlind L. Gerloff; Fred Cohen
Secondary structure prediction and unrefined tertiary structure prediction for cyclin A, B, and D.
Proteins 1996;24(1):18-34.
1996: Z Huang; Stanley B Prusiner; Fred Cohen
Structures of prion proteins and conformational models for prion diseases.
Current topics in microbiology and immunology 1996;207():49-67.
1995: R Li; G L Kenyon; Fred Cohen; X Chen; B Gong; J N Dominguez; E Davidson; G Kurzban; R E Miller; E O Nuzum
In vitro antimalarial activity of chalcones and their derivatives.
Journal of medicinal chemistry 1995;38(26):5031-7.
1995: Kiyotoshi Kaneko; David Peretz; K M Pan; T C Blochberger; Holger Wille; Ruth Gabizon; O H Griffith; Fred Cohen; Michael A Baldwin; Stanley B Prusiner
Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):11160-4.
1995: T Defay; Fred Cohen
Evaluation of current techniques for ab initio protein structure prediction.
Proteins 1995;23(3):431-45.
1995: Glenn C Telling; Michael Scott; James A Mastrianni; Ruth Gabizon; M Torchia; Fred Cohen; Stephen J DeArmond; Stanley B Prusiner
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein.
Cell 1995;83(1):79-90.
1995: J T Nguyen; H Inouye; Michael A Baldwin; Robert J Fletterick; Fred Cohen; Stanley B Prusiner; Daniel A Kirschner
X-ray diffraction of scrapie prion rods and PrP peptides.
Journal of molecular biology 1995;252(4):412-22.
1995: T Nanevicz; M Ishii; L Wang; M Chen; J Chen; Christoph W Turck; Fred Cohen; Shaun R Coughlin
Mechanisms of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site.
The Journal of biological chemistry 1995;270(37):21619-25.
1995: J M Troyer; Fred Cohen
Protein conformational landscapes: energy minimization and clustering of a long molecular dynamics trajectory.
Proteins 1995;23(1):97-110.
1995: Y Pan; T DeFay; J Gitschier; Fred Cohen
Proposed structure of the A domains of factor VIII by homology modelling.
Nature structural biology 1995;2(9):740-4.
1995: Michael A Baldwin; Fred Cohen; Stanley B Prusiner
Prion protein isoforms, a convergence of biological and structural investigations.
The Journal of biological chemistry 1995;270(33):19197-200.
1995: Hui Zhang; Kiyotoshi Kaneko; J T Nguyen; T L Livshits; Michael A Baldwin; Fred Cohen; Tom L James; Stanley B Prusiner
Conformational transitions in peptides containing two putative alpha-helices of the prion protein.
Journal of molecular biology 1995;250(4):514-26.
1995: Steven L Kazmirski; D O Alonso; Fred Cohen; Stanley B Prusiner; Valerie Daggett
Theoretical studies of sequence effects on the conformational properties of a fragment of the prion protein: implications for scrapie formation.
Chemistry & biology 1995;2(5):305-15.
1995: J Nguyen; Michael A Baldwin; Fred Cohen; Stanley B Prusiner
Prion protein peptides induce alpha-helix to beta-sheet conformational transitions.
Biochemistry 1995;34(13):4186-92.
1995: H M Schätzl; M Da Costa; L Taylor; Fred Cohen; Stanley B Prusiner
Prion protein gene variation among primates.
Journal of molecular biology 1995;245(4):362-74.
1994: D P Hearst; Fred Cohen
GRAFTER: a computational aid for the design of novel proteins.
Protein engineering 1994;7(12):1411-21.
1994: Philip J Rosenthal; C S Ring; X Chen; Fred Cohen
Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases.
Journal of molecular biology 1994;241(2):312-6.
1994: N G Hunt; Lydia Gregoret; Fred Cohen
The origins of protein secondary structure. Effects of packing density and hydrogen bonding studied by a fast conformational search.
Journal of molecular biology 1994;241(2):214-25.
1994: S Ma; M J McGregor; Fred Cohen; P V Pallai
Conformation of CD4-derived cyclic hexapeptides by NMR and molecular dynamics.
Biopolymers 1994;34(8):987-1000.
1994: Z Huang; Jean-Marc Gabriel; Michael A Baldwin; Robert J Fletterick; Stanley B Prusiner; Fred Cohen
Proposed three-dimensional structure for the cellular prion protein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):7139-43.
1994: Fred Cohen; K M Pan; Z Huang; M Baldwin; Robert J Fletterick; Stanley B Prusiner
Structural clues to prion replication.
Science (New York, N.Y.) 1994;264(5158):530-1.
1994: Michael A Baldwin; K M Pan; J Nguyen; Z Huang; Darlene Groth; A Serban; M Gasset; IR Mehlhorn; Robert J Fletterick; Fred Cohen
Spectroscopic characterization of conformational differences between PrPC and PrPSc: an alpha-helix to beta-sheet transition.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;343(1306):435-41.
1994: N L Harris; Scott Presnell; Fred Cohen
Four helix bundle diversity in globular proteins.
Journal of molecular biology 1994;236(5):1356-68.
1994: L Jin; Fred Cohen; James A Wells
Structure from function: screening structural models with functional data.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):113-7.
1993: E Sun; Fred Cohen
Computer-assisted drug discovery--a review.
Gene 1993;137(1):127-32.
1993: B I Cohen; Scott Presnell; Fred Cohen
Origins of structural diversity within sequentially identical hexapeptides.
Protein science : a publication of the Protein Society 1993;2(12):2134-45.
1993: Benjamin Aroeti; P A Kosen; Irwin D Kuntz; Fred Cohen; Keith E Mostov
Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor.
The Journal of cell biology 1993;123(5):1149-60.
1993: K M Pan; M Baldwin; J Nguyen; M Gasset; A Serban; Darlene Groth; IR Mehlhorn; Z Huang; Robert J Fletterick; Fred Cohen
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):10962-6.
1993: J P Boissel; W R Lee; Scott Presnell; Fred Cohen; H F Bunn
Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure.
The Journal of biological chemistry 1993;268(21):15983-93.
1993: Fred Cohen
The parallel beta helix of pectate lyase C: something to sneeze at.
Science (New York, N.Y.) 1993;260(5113):1444-5.
1993: C S Ring; Fred Cohen
Modeling protein structures: construction and their applications.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(9):783-90.
1993: Scott Presnell; B I Cohen; Fred Cohen
MacMatch: a tool for pattern-based protein secondary structure prediction.
Computer applications in the biosciences : CABIOS 1993;9(3):373-4.
1993: C S Ring; E Sun; James H McKerrow; G K Lee; Philip J Rosenthal; Irwin D Kuntz; Fred Cohen
Structure-based inhibitor design by using protein models for the development of antiparasitic agents.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3583-7.
1993: Scott Presnell; Fred Cohen
Artificial neural networks for pattern recognition in biochemical sequences.
Annual review of biophysics and biomolecular structure 1993;22():283-98.
1993: SA Gillmor; Fred Cohen
New strategies for pharmaceutical design.
Receptor 1993;3(3):155-63.
1992: E Shtivelman; Fred Cohen; John M Bishop
A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5472-6.
1992: C S Ring; D G Kneller; R Langridge; Fred Cohen
Taxonomy and conformational analysis of loops in proteins.
Journal of molecular biology 1992;224(3):685-99.
1992: Scott Presnell; B I Cohen; Fred Cohen
A segment-based approach to protein secondary structure prediction.
Biochemistry 1992;31(4):983-93.
1991: Fred Cohen; Lydia Gregoret; P Amiri; Kenneth Aldape; J Railey; James H McKerrow
Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling.
Biochemistry 1991;30(47):11221-9.
1991: N Colloc'h; Fred Cohen
Beta-breakers: an aperiodic secondary structure.
Journal of molecular biology 1991;221(2):603-13.
1991: Lydia Gregoret; Fred Cohen
Protein folding. Effect of packing density on chain conformation.
Journal of molecular biology 1991;219(1):109-22.
1991: Fred Cohen; G J Strewler; M S Bradley; M Carlquist; M Nilsson; M Ericsson; T L Ciardelli; Robert A Nissenson
Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone.
The Journal of biological chemistry 1991;266(3):1997-2004.
1991: B M Curtis; Scott Presnell; S Srinivasan; H Sassenfeld; R Klinke; E Jeffery; D Cosman; CJ March; Fred Cohen
Experimental and theoretical studies of the three-dimensional structure of human interleukin-4.
Proteins 1991;11(2):111-9.
1991: B I Cohen; Scott Presnell; Fred Cohen
Pattern-based approaches to protein structure prediction.
Methods in enzymology 1991;202():252-68.
1991: Lydia Gregoret; Stephen D Rader; Robert J Fletterick; Fred Cohen
Hydrogen bonds involving sulfur atoms in proteins.
Proteins 1991;9(2):99-107.
1990: Erin K Bradley; J F Thomason; Fred Cohen; P A Kosen; Irwin D Kuntz
Studies of synthetic helical peptides using circular dichroism and nuclear magnetic resonance.
Journal of molecular biology 1990;215(4):607-22.
1990: D G Kneller; Fred Cohen; R Langridge
Improvements in protein secondary structure prediction by an enhanced neural network.
Journal of molecular biology 1990;214(1):171-82.
1990: L Chiche; Lydia Gregoret; Fred Cohen; Peter A Kollman
Protein model structure evaluation using the solvation free energy of folding.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):3240-3.
1990: Lydia Gregoret; Fred Cohen
Novel method for the rapid evaluation of packing in protein structures.
Journal of molecular biology 1990;211(4):959-74.
1989: Scott Presnell; Fred Cohen
Topological distribution of four-alpha-helix bundles.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6592-6.
1989: B Landgraf; Fred Cohen; Kendall A Smith; Robert A Gadski; Thomas L Ciardelli
Structural significance of the C-terminal amphiphilic helix of interleukin-2.
The Journal of biological chemistry 1989;264(2):816-22.
1989: Fred Cohen; Lydia Gregoret; Scott Presnell; Irwin D Kuntz
Protein structure predictions: new theoretical approaches.
Progress in clinical and biological research 1989;289():75-85.
1988: Thomas L Ciardelli; B Landgraf; Robert A Gadski; J Strnad; Fred Cohen; Kendall A Smith
A design approach to the structural analysis of interleukin-2.
Journal of molecular recognition : JMR 1988;1(1):42-7.
1988: D Bashford; Fred Cohen; M Karplus; Irwin D Kuntz; D L Weaver
Diffusion-collision model for the folding kinetics of myoglobin.
Proteins 1988;4(3):211-27.
1987: Fred Cohen; Irwin D Kuntz
Prediction of the three-dimensional structure of human growth hormone.
Proteins 1987;2(2):162-6.
1987: M R Hurle; C Robert Matthews; Fred Cohen; Irwin D Kuntz; A Toumadje; W C Johnson
Prediction of the tertiary structure of the alpha-subunit of tryptophan synthase.
Proteins 1987;2(3):210-24.
1986: Fred Cohen; P A Kosen; Irwin D Kuntz; L B Epstein; T L Ciardelli; Kendall A Smith
Structure-activity studies of interleukin-2.
Science (New York, N.Y.) 1986;234(4774):349-52.
1986: C C Blake; D W Rice; Fred Cohen
A "helix-scissors" mechanism for the hinge-bending conformational change in phosphoglycerate kinase.
International journal of peptide and protein research 1986;27(5):443-8.
1986: Fred Cohen; B Sater; K R Feingold
Potential danger of extending SMBG techniques to hospital wards.
Diabetes care 1986;9(3):320-2.
1986: Fred Cohen; R M Abarbanel; Irwin D Kuntz; Robert J Fletterick
Turn prediction in proteins using a pattern-matching approach.
Biochemistry 1986;25(1):266-75.
1984: M A Blanar; D Kneller; A J Clark; A E Karu; Fred Cohen; R Langridge; Irwin D Kuntz
A model for the core structure of the Escherichia coli RecA protein.
Cold Spring Harbor symposia on quantitative biology 1984;49():507-11.
1983: Fred Cohen; R M Abarbanel; Irwin D Kuntz; Robert J Fletterick
Secondary structure assignment for alpha/beta proteins by a combinatorial approach.
Biochemistry 1983;22(21):4894-904.
1982: M J Sternberg; Fred Cohen; W R Taylor
A combinational approach to the prediction of the tertiary fold of globular proteins.
Biochemical Society transactions 1982;10(5):299-301.
1982: M J Sternberg; Fred Cohen
Interferon: a tertiary structure predicted from amino acid sequences.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1982;299(1094):125-7.
1982: Fred Cohen; M J Sternberg; W R Taylor
Analysis and prediction of the packing of alpha-helices against a beta-sheet in the tertiary structure of globular proteins.
Journal of molecular biology 1982;156(4):821-62.
1981: M J Sternberg; Fred Cohen; W R Taylor; R J Feldmann
Analysis and predication of structural motifs in the glycolytic enzymes.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1981;293(1063):177-89.
1981: Fred Cohen; M J Sternberg; W R Taylor
Analysis of the tertiary structure of protein beta-sheet sandwiches.
Journal of molecular biology 1981;148(3):253-72.
1981: Fred Cohen; J Novotný; M J Sternberg; D G Campbell; A F Williams
Analysis of structural similarities between brain Thy-1 antigen and immunoglobulin domains. Evidence for an evolutionary relationship and a hypothesis for its functional significance.
The Biochemical journal 1981;195(1):31-40.
1980: Fred Cohen; M J Sternberg; D C Phillips; Irwin D Kuntz; P A Kollman
A diffusion--collision--adhesion model for the kinetics of myoglobin refolding.
Nature 1980;286(5773):632-4.
1980: Fred Cohen; M J Sternberg; W R Taylor
Analysis and prediction of protein beta-sheet structures by a combinatorial approach.
Nature 1980;285(5764):378-82.
1980: Fred Cohen; M J Sternberg
On the prediction of protein structure: The significance of the root-mean-square deviation.
Journal of molecular biology 1980;138(2):321-33.
1980: Fred Cohen; M J Sternberg
On the use of chemically derived distance constraints in the prediction of protein structure with myoglobin as an example.
Journal of molecular biology 1980;137(1):9-22.
1979: Fred Cohen; T J Richmond; F M Richards
Protein folding: evaluation of some simple rules for the assembly of helices into tertiary structures with myoglobin as an example.
Journal of molecular biology 1979;132(3):275-88.