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Derek M. Dykxhoorn

Research Profile

Phenomena

RNA Interference

Chemicals & Drugs

Physiology

Anatomy

Hela Cells

Procedures

Genetic Therapy

Living Beings

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Publications

TOP 3
Evadnie Rampersaud; David Seo; Jeffery M Vance; Natasha Hudson; Armando Mendez; Karyn Meshbane; Anthony Musto; Lubov Nathanson; Margaret A Pericak-Vance; Richard L Belton; Michael Cuccaro; Sylvia Daunert; Sapna K. Deo; Amy Dressen; Derek M. Dykxhoorn; Jeffrey Farmer; Pascal J Goldschmidt-Clermont
Genomic signatures of a global fitness index in a multi-ethnic cohort of women.
Shoukang Zhu; Degen Zhuo; Shanming Deng; Derek M. Dykxhoorn; Pascal J Goldschmidt-Clermont; Joshua M Hare; Chunling Jia; Qi Ma; Liyong Wang; Jianqin Wei; Falin Yang; Taifang Zhang; Chunming Dong
MicroRNA-10A* and MicroRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group A2.
Brooke A DeRosa; Gaurav K Dubey; Michael Cuccaro; Joycelyn M Lee; Margaret Pericak-Vance; Jessica M Van Baaren; Jeffery Vance; Derek M. Dykxhoorn
Derivation of autism spectrum disorder-specific induced pluripotent stem cells from peripheral blood mononuclear cells.

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All Publications

2013: Evadnie Rampersaud; David Seo; Jeffery M Vance; Natasha Hudson; Armando Mendez; Karyn Meshbane; Anthony Musto; Lubov Nathanson; Margaret A Pericak-Vance; Richard L Belton; Michael Cuccaro; Sylvia Daunert; Sapna K. Deo; Amy Dressen; Derek M. Dykxhoorn; Jeffrey Farmer; Pascal J Goldschmidt-Clermont
Genomic signatures of a global fitness index in a multi-ethnic cohort of women.
Annals of human genetics 2013;77(2):147-57.
2013: Shoukang Zhu; Degen Zhuo; Shanming Deng; Derek M. Dykxhoorn; Pascal J Goldschmidt-Clermont; Joshua M Hare; Chunling Jia; Qi Ma; Liyong Wang; Jianqin Wei; Falin Yang; Taifang Zhang; Chunming Dong
MicroRNA-10A* and MicroRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group A2.
Circulation research 2013;112(1):152-64.
2012: Brooke A DeRosa; Gaurav K Dubey; Michael Cuccaro; Joycelyn M Lee; Margaret Pericak-Vance; Jessica M Van Baaren; Jeffery Vance; Derek M. Dykxhoorn
Derivation of autism spectrum disorder-specific induced pluripotent stem cells from peripheral blood mononuclear cells.
Neuroscience letters 2012;516(1):9-14.
2012: Reema A Ishteiwy; Toby M Ward; Derek M. Dykxhoorn; Kerry L Burnstein
The microRNA -23b/-27b cluster suppresses the metastatic phenotype of castration-resistant prostate cancer cells.
PloS one 2012;7(12):e52106.
2011: Lee Adam Wheeler; Radiana Trifonova; Vladimir Vrbanac; Emre Basar; Shannon McKernan; Zhan Xu; Edward Seung; Maud Deruaz; Tim Dudek; Jon Ivar Einarsson; Linda Yang; Todd M Allen; Andrew D Luster; Andrew M Tager; Derek M. Dykxhoorn; Judy Lieberman
Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras.
The Journal of clinical investigation 2011;121(6):2401-12.
2010: Derek M. Dykxhoorn
MicroRNAs and metastasis: little RNAs go a long way.
Cancer research 2010;70(16):6401-6.
2010: N Manjunath; Derek M. Dykxhoorn
Advances in synthetic siRNA delivery.
Discovery medicine 2010;9(48):418-30.
2010: Derek M. Dykxhoorn
Advances in cell-type specific delivery of RNAi-based therapeutics.
IDrugs : the investigational drugs journal 2010;13(5):325-31.
2010: Monika Dominska; Derek M. Dykxhoorn
Breaking down the barriers: siRNA delivery and endosome escape.
Journal of cell science 2010;123(Pt 8):1183-9.
2009: Ashish Lal; Francisco Navarro; Christopher A. Maher; Laura E Maliszewski; Nan Yan; Elizabeth O'Day; Dipanjan Chowdhury; Derek M. Dykxhoorn; Perry Tsai; Oliver Hofmann; Kevin G Becker; Myriam Gorospe; Winston Hide; Judy Lieberman
miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements.
Molecular cell 2009;35(5):610-25.
2009: Ashish Lal; Yunfeng Pan; Francisco Navarro; Derek M. Dykxhoorn; Lisa Moreau; Eti Meire; Zvi Bentwich; Judy Lieberman; Dipanjan Chowdhury
miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.
Nature structural & molecular biology 2009;16(5):492-8.
2009: Derek M. Dykxhoorn
RNA interference as an anticancer therapy: a patent perspective.
Expert opinion on therapeutic patents 2009;19(4):475-91.
2009: Derek M. Dykxhoorn; Yichao Wu; Huangming Xie; Fengyan Yu; Ashish Lal; Fabio Petrocca; Denis Martinvalet; Erwei Song; Bing Lim; Judy Lieberman
miR-200 enhances mouse breast cancer cell colonization to form distant metastases.
PloS one 2009;4(9):e7181.
2008: Dipanjan Chowdhury; Xingzhi Xu; Xueyan Zhong; Fariyal Ahmed; Jianing Zhong; Ji Liao; Derek M. Dykxhoorn; David M Weinstock; Gerd P Pfeifer; Judy Lieberman
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.
Molecular cell 2008;31(1):33-46.
2008: Denis Martinvalet; Derek M. Dykxhoorn; Roger Ferrini; Judy Lieberman
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.
Cell 2008;133(4):681-92.
2008: Abraham L Brass; Derek M. Dykxhoorn; Yair Benita; Nan Yan; Alan Engelman; Ramnik Xavier; Judy Lieberman; Stephen J Elledge
Identification of host proteins required for HIV infection through a functional genomic screen.
Science (New York, N.Y.) 2008;319(5865):921-6.
2008: Derek M. Dykxhoorn; Dipanjan Chowdhury; Judy Lieberman
RNA interference and cancer: endogenous pathways and therapeutic approaches.
Advances in experimental medicine and biology 2008;615():299-329.
2008: Ashish Lal; Hyeon Ho Kim; Kotb Abdelmohsen; Yuki Kuwano; Rudolf Pullmann; Subramanya Srikantan; Ramesh Subrahmanyam; Jennifer L Martindale; Xiaoling Yang; Fariyal Ahmed; Francisco Navarro; Derek M. Dykxhoorn; Judy Lieberman; Myriam Gorospe
p16(INK4a) translation suppressed by miR-24.
PloS one 2008;3(3):e1864.
2007: Aleksandra Glodek; Yi Le; Derek M. Dykxhoorn; S-Y Park; Gustavo Mostoslavsky; R Mulligan; J Lieberman; H E Beggs; Marek Honczarenko; Leslie E Silberstein
Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.
Leukemia 2007;21(8):1723-32.
2007: Derek M. Dykxhoorn
MicroRNAs in viral replication and pathogenesis.
DNA and cell biology 2007;26(4):239-49.
2006: Derek M. Dykxhoorn; Judy Lieberman
Knocking down disease with siRNAs.
Cell 2006;126(2):231-5.
2006: Derek M. Dykxhoorn; Judy Lieberman
Silencing viral infection.
PLoS medicine 2006;3(7):e242.
2006: Derek M. Dykxhoorn; Lisa D Schlehuber; Irving M London; Judy Lieberman
Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5953-8.
2006: Derek M. Dykxhoorn; Deborah Palliser; Judy Lieberman
The silent treatment: siRNAs as small molecule drugs.
Gene therapy 2006;13(6):541-52.
2006: Derek M. Dykxhoorn; Judy Lieberman
Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs.
Annual review of biomedical engineering 2006;8():377-402.
2005: Toshihiko Oka; Eliza Vasile; Marsha Penman; Carl D Novina; Derek M. Dykxhoorn; Daniel Ungar; Frederick M Hughson; Monty Krieger
Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.
The Journal of biological chemistry 2005;280(38):32736-45.
2005: Sang-Kyung Lee; Derek M. Dykxhoorn; Priti Kumar; Shahin Ranjbar; Erwei Song; Laura E Maliszewski; Vanessa François-Bongarçon; Anne E Goldfeld; N Manjunath Swamy; Judy Lieberman; Premlata Shankar
Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV.
Blood 2005;106(3):818-26.
2005: Erwei Song; Pengcheng Zhu; Sang-Kyung Lee; Dipanjan Chowdhury; Steven Kussman; Derek M. Dykxhoorn; Yi Feng; Deborah Palliser; David B Weiner; Premlata Shankar; Wayne A Marasco; Judy Lieberman
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors.
Nature biotechnology 2005;23(6):709-17.
2005: Derek M. Dykxhoorn
P-bodies and RNAi: The missing link?
Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research 2005;2(1):105-6.
2005: Derek M. Dykxhoorn; Judy Lieberman
The silent revolution: RNA interference as basic biology, research tool, and therapeutic.
Annual review of medicine 2005;56():401-23.
2003: Erwei Song; Sang-Kyung Lee; Derek M. Dykxhoorn; Carl D Novina; Dong Zhang; Keith Crawford; Jan Cerny; Phillip A Sharp; Judy Lieberman; N Manjunath; Premlata Shankar
Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages.
Journal of virology 2003;77(13):7174-81.
2003: Derek M. Dykxhoorn; Carl D Novina; Phillip A Sharp
Killing the messenger: short RNAs that silence gene expression.
Nature reviews. Molecular cell biology 2003;4(6):457-67.
2003: Sheila A Stewart; Derek M. Dykxhoorn; Deborah Palliser; Hana Mizuno; Evan Y Yu; Dong Sung An; David M Sabatini; Irvin S Y Chen; William C Hahn; Phillip A Sharp; Robert A. Weinberg; Carl D Novina
Lentivirus-delivered stable gene silencing by RNAi in primary cells.
RNA (New York, N.Y.) 2003;9(4):493-501.
2002: Carl D Novina; Michael F Murray; Derek M. Dykxhoorn; Paul J Beresford; Jonathan Riess; Sang-Kyung Lee; Ronald G Collman; Judy Lieberman; Premlata Shankar; Phillip A Sharp
siRNA-directed inhibition of HIV-1 infection.
Nature medicine 2002;8(7):681-6.
1997: Derek M. Dykxhoorn; R St Pierre; O Van Ham; T Linn
An efficient protocol for linker scanning mutagenesis: analysis of the translational regulation of an Escherichia coli RNA polymerase subunit gene.
Nucleic acids research 1997;25(21):4209-18.
1996: Derek M. Dykxhoorn; R St Pierre; T Linn
A set of compatible tac promoter expression vectors.
Gene 1996;177(1-2):133-6.
1996: Derek M. Dykxhoorn; R St Pierre; T Linn
Synthesis of the beta and beta' subunits of Escherichia coli RNA polymerase is autogenously regulated in vivo by both transcriptional and translational mechanisms.
Molecular microbiology 1996;19(3):483-93.