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Mark Bycroft

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TOP 3
Mark Bycroft
Recognition of non-methyl histone marks.
Christopher Stapf; Mark Bycroft; Edward Cartwright; Kay Hofmann; Alexander Buchberger
The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors.
Aruna Sathyamurthy; Mark D Allen; Stefan M V Freund; Christopher M Johnson; Mark Bycroft
Structural basis of p63α SAM domain mutants involved in AEC syndrome.

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All Publications

2011: Mark Bycroft
Recognition of non-methyl histone marks.
Current opinion in structural biology 2011;21(6):761-6.
2011: Christopher Stapf; Mark Bycroft; Edward Cartwright; Kay Hofmann; Alexander Buchberger
The general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactors.
The Journal of biological chemistry 2011;286(44):38670-8.
2011: Aruna Sathyamurthy; Mark D Allen; Stefan M V Freund; Christopher M Johnson; Mark Bycroft
Structural basis of p63α SAM domain mutants involved in AEC syndrome.
The FEBS journal 2011;278(15):2680-8.
2010: Maria M García-Alai; Mark D Allen; Andreas C Joerger; Mark Bycroft
The structure of the FYR domain of transforming growth factor beta regulator 1.
Protein science : a publication of the Protein Society 2010;19(7):1432-8.
2010: Alessandro Vezzoli; Nicolas Bonadies; Mark D Allen; Stefan M V Freund; Clara M Santiveri; Brynn T Kvinlaug; Brian J P Huntly; Berthold Göttgens; Mark Bycroft
Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1.
Nature structural & molecular biology 2010;17(5):617-9.
2009: Katja Knauth; Edward Cartwright; Stefan M V Freund; Mark Bycroft; Alexander Buchberger
VHL mutations linked to type 2C von Hippel-Lindau disease cause extensive structural perturbations in pVHL.
The Journal of biological chemistry 2009;284(16):10514-22.
2009: Sarah Burge; Daniel P Teufel; Fiona M Townsley; Stefan M V Freund; Mark Bycroft; Alan Fersht
Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3142-7.
2009: Bernhard C Lechtenberg; Mark D Allen; Trevor J Rutherford; Stefan M V Freund; Mark Bycroft
Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2.
Protein science : a publication of the Protein Society 2009;18(3):657-61.
2008: Clara M Santiveri; Bernhard C Lechtenberg; Mark D Allen; Aruna Sathyamurthy; Agnès M Jaulent; Stefan M V Freund; Mark Bycroft
The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine.
Journal of molecular biology 2008;382(5):1107-12.
2008: Charles G Grummitt; Fiona M Townsley; Christopher M Johnson; Alan J Warren; Mark Bycroft
Structural consequences of nucleophosmin mutations in acute myeloid leukemia.
The Journal of biological chemistry 2008;283(34):23326-32.
2007: Mark D Allen; Mark Bycroft
The solution structure of the ZnF UBP domain of USP33/VDU1.
Protein science : a publication of the Protein Society 2007;16(9):2072-5.
2007: Mark D Allen; Tomasz L Religa; Stefan M V Freund; Mark Bycroft
Solution structure of the BRK domains from CHD7.
Journal of molecular biology 2007;371(5):1135-40.
2007: Daniel P Teufel; Stefan M V Freund; Mark Bycroft; Alan Fersht
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(17):7009-14.
2006: Viknesh Sivanathan; Mark D Allen; Charissa de Bekker; Rachel Baker; Lidia K Arciszewska; Stefan M V Freund; Mark Bycroft; Jan Löwe; David J Sherratt
The FtsK gamma domain directs oriented DNA translocation by interacting with KOPS.
Nature structural & molecular biology 2006;13(11):965-72.
2006: Mark D Allen; Charles G Grummitt; Christine Hilcenko; Sandra Young Min; Louise M Tonkin; Christopher M Johnson; Stefan M V Freund; Mark Bycroft; Alan J Warren
Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase.
The EMBO journal 2006;25(19):4503-12.
2006: Mark D Allen; Alexander Buchberger; Mark Bycroft
The PUB domain functions as a p97 binding module in human peptide N-glycanase.
The Journal of biological chemistry 2006;281(35):25502-8.
2006: Stephan Heeb; Sarah A Kuehne; Mark Bycroft; Sorana Crivii; Mark D Allen; Dieter Haas; Miguel Cámara; Paul Williams
Functional analysis of the post-transcriptional regulator RsmA reveals a novel RNA-binding site.
Journal of molecular biology 2006;355(5):1026-36.
2006: Grace W Yu; Mark D Allen; Antonina Andreeva; Alan Fersht; Mark Bycroft
Solution structure of the C4 zinc finger domain of HDM2.
Protein science : a publication of the Protein Society 2006;15(2):384-9.
2005: Markus A Seeliger; Martin Spichty; Sadie E Kelly; Mark Bycroft; Stefan M V Freund; Martin Karplus; Laura S Itzhaki
Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins.
The Journal of biological chemistry 2005;280(34):30448-59.
2005: Georgios Karras; Georg Kustatscher; Heeran R Buhecha; Mark D Allen; Céline Pugieux; Fiona Sait; Mark Bycroft; Andreas G Ladurner
The macro domain is an ADP-ribose binding module.
The EMBO journal 2005;24(11):1911-20.
2005: Richard L Weinberg; Dmitry B Veprintsev; Mark Bycroft; Alan Fersht
Comparative binding of p53 to its promoter and DNA recognition elements.
Journal of molecular biology 2005;348(3):589-96.
2005: Chi Fung Lee; Mark D Allen; Mark Bycroft; Kam-Bo Wong
Electrostatic interactions contribute to reduced heat capacity change of unfolding in a thermophilic ribosomal protein l30e.
Journal of molecular biology 2005;348(2):419-31.
2005: Yuk-Yin Cheung; Sonia Y Lam; Wai-Kit Chu; Mark D Allen; Mark Bycroft; Kam-Bo Wong
Crystal structure of a hyperthermophilic archaeal acylphosphatase from Pyrococcus horikoshii--structural insights into enzymatic catalysis, thermostability, and dimerization.
Biochemistry 2005;44(12):4601-11.
2004: Roger B Dodd; Mark D Allen; Stephanie E Brown; Christopher M Sanderson; Lidia M Duncan; Paul J Lehner; Mark Bycroft; Randy J Read
Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain.
The Journal of biological chemistry 2004;279(51):53840-7.
2004: Alejandro D Nadra; Tommaso Eliseo; Yu-Keung Mok; C L Almeida; Mark Bycroft; Maurizio Paci; Gonzalo De Prat-Gay; Daniel O Cicero
Solution structure of the HPV-16 E2 DNA binding domain, a transcriptional regulator with a dimeric beta-barrel fold.
Journal of biomolecular NMR 2004;30(2):211-4.
2004: Richard L Weinberg; Stefan M V Freund; Dmitry B Veprintsev; Mark Bycroft; Alan Fersht
Regulation of DNA binding of p53 by its C-terminal domain.
Journal of molecular biology 2004;342(3):801-11.
2004: Clara M Santiveri; José Manuel Pérez-Cañadillas; Murali K Vadivelu; Mark D Allen; Trevor J Rutherford; Nicholas A Watkins; Mark Bycroft
NMR structure of the alpha-hemoglobin stabilizing protein: insights into conformational heterogeneity and binding.
The Journal of biological chemistry 2004;279(33):34963-70.
2004: Yuk-Yin Cheung; Mark D Allen; Mark Bycroft; Kam-Bo Wong
Crystallization and preliminary crystallographic analysis of an acylphosphatase from the hyperthermophilic archaeon Pyrococcus horikoshii.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 7):1308-10.
2004: Denis Tsz-Ming Ip; Siu-Hong Chan; Mark D Allen; Mark Bycroft; David C C Wan; Kam-Bo Wong
Crystallization and preliminary crystallographic analysis of a novel orange fluorescent protein from the Cnidaria tube anemone Cerianthus sp.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 2):340-1.
2004: Yu Wai Chen; Mark D Allen; Dmitry B Veprintsev; Jan Löwe; Mark Bycroft
The structure of the AXH domain of spinocerebellar ataxin-1.
The Journal of biological chemistry 2004;279(5):3758-65.
2003: Aruna Sathyamurthy; Mark D Allen; Alexey G Murzin; Mark Bycroft
Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2).
The Journal of biological chemistry 2003;278(47):46968-73.
2003: Huong J T T Tran; Mark D Allen; Jan Löwe; Mark Bycroft
Structure of the Jab1/MPN domain and its implications for proteasome function.
Biochemistry 2003;42(39):11460-5.
2003: Leanne M Slater; Mark D Allen; Mark Bycroft
Structural variation in PWWP domains.
Journal of molecular biology 2003;330(3):571-6.
2003: Mark D Allen; Ashley M Buckle; Suzanne C Cordell; Jan Löwe; Mark Bycroft
The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of macroH2A.
Journal of molecular biology 2003;330(3):503-11.
2003: Kam-Bo Wong; Chi Fung Lee; Siu-Hong Chan; Tak-Yuen Leung; Yu Wai Chen; Mark Bycroft
Solution structure and thermal stability of ribosomal protein L30e from hyperthermophilic archaeon Thermococcus celer.
Protein science : a publication of the Protein Society 2003;12(7):1483-95.
2003: Yu Wai Chen; Mark Bycroft; Kam-Bo Wong
Crystal structure of ribosomal protein L30e from the extreme thermophile Thermococcus celer: thermal stability and RNA binding.
Biochemistry 2003;42(10):2857-65.
2002: Oliver Schon; Assaf Friedler; Mark Bycroft; Stefan M V Freund; Alan Fersht
Molecular mechanism of the interaction between MDM2 and p53.
Journal of molecular biology 2002;323(3):491-501.
2002: Mark Allen; Assaf Friedler; Oliver Schon; Mark Bycroft
The structure of an FF domain from human HYPA/FBP11.
Journal of molecular biology 2002;323(3):411-6.
2001: SF Poget; Stefan M V Freund; Mark J Howard; Mark Bycroft
The ligand-binding loops in the tunicate C-type lectin TC14 are rigid.
Biochemistry 2001;40(37):10966-72.
2001: Kam-Bo Wong; WK Wang; Mark R Proctor; Mark Bycroft; Yu Wai Chen
Crystallization and preliminary crystallographic studies of a ribosomal protein L30e from the hyperthermophilic archaeon Thermococcus celer.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 6):865-6.
2001: WK Wang; Mark Bycroft; N W Foster; Ashley M Buckle; Alan Fersht; Yu Wai Chen
Structure of the C-terminal sterile alpha-motif (SAM) domain of human p73 alpha.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 4):545-51.
2001: Alexander Buchberger; Mark J Howard; M Proctor; Mark Bycroft
The UBX domain: a widespread ubiquitin-like module.
Journal of molecular biology 2001;307(1):17-24.
2000: G B Legge; SF Poget; Mark R Proctor; Stefan M V Freund; Mark Bycroft
Letter to the editor: 1H, 13C and 15N NMR assignments of the C-type lectin TC14.
Journal of biomolecular NMR 2000;18(3):283-4.
2000: Alexander Buchberger; Mark J Howard; Stefan M V Freund; M Proctor; P J Butler; Alan Fersht; Mark Bycroft
Biophysical characterization of elongin C from Saccharomyces cerevisiae.
Biochemistry 2000;39(36):11137-46.
2000: WK Wang; Mark R Proctor; Ashley M Buckle; Mark Bycroft; Yu Wai Chen
Crystallization and preliminary crystallographic studies of a SAM domain at the C-terminus of human p73alpha.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 6):769-71.
2000: Yu-Keung Mok; Leonardo G Alonso; Luís Maurício T R Lima; Mark Bycroft; Gonzalo De Prat-Gay
Folding of a dimeric beta-barrel: residual structure in the urea denatured state of the human papillomavirus E2 DNA binding domain.
Protein science : a publication of the Protein Society 2000;9(4):799-811.
2000: A Ramos; stefan gruenert; Jan Adams; DR Micklem; Mark R Proctor; Stefan M V Freund; Mark Bycroft; Daniel St Johnston; Gabriele Varani
RNA recognition by a Staufen double-stranded RNA-binding domain.
The EMBO journal 2000;19(5):997-1009.
2000: Mark Bycroft; Kira J Weissman; James Staunton; Peter F Leadlay
Efficient purification and kinetic characterization of a bimodular derivative of the erythromycin polyketide synthase.
European journal of biochemistry / FEBS 2000;267(2):520-6.
1999: A Ranganathan; Máire C Timoney; Mark Bycroft; Jesús Cortés; Iain Thomas; Barrie Wilkinson; Laurenz Kellenberger; U Hanefeld; I S Galloway; James Staunton; Peter F Leadlay
Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues.
Chemistry & biology 1999;6(10):731-41.
1999: S P Evans; Mark Bycroft
NMR structure of the N-terminal domain of Saccharomyces cerevisiae RNase HI reveals a fold with a strong resemblance to the N-terminal domain of ribosomal protein L9.
Journal of molecular biology 1999;291(3):661-9.
1999: SF Poget; G B Legge; Mark R Proctor; P J Butler; Mark Bycroft; R L Williams
The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D -galactose.
Journal of molecular biology 1999;290(4):867-79.
1999: Kam-Bo Wong; Brian S DeDecker; Stefan M V Freund; Mark R Proctor; Mark Bycroft; Alan Fersht
Hot-spot mutants of p53 core domain evince characteristic local structural changes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8438-42.
1999: IE Holzbaur; R C Harris; Mark Bycroft; J Cortes; Christian P Bisang; James Staunton; Brian A M Rudd; Peter F Leadlay
Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase.
Chemistry & biology 1999;6(4):189-95.
1998: Kira J Weissman; Mark Bycroft; A L Cutter; U Hanefeld; EJ Frost; Máire C Timoney; R Harris; S Handa; Marc P Roddis; James Staunton; Peter F Leadlay
Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase.
Chemistry & biology 1998;5(12):743-54.
1998: Kira J Weissman; Mark Bycroft; James Staunton; Peter F Leadlay
Origin of starter units for erythromycin biosynthesis.
Biochemistry 1998;37(31):11012-7.
1998: S Fong; Mark Bycroft; J Clarke; Stefan M V Freund
Characterisation of urea-denatured states of an immunoglobulin superfamily domain by heteronuclear NMR.
Journal of molecular biology 1998;278(2):417-29.
1998: Olga Perisic; S Fong; D E Lynch; Mark Bycroft; Roger L Williams
Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2.
The Journal of biological chemistry 1998;273(3):1596-604.
1997: Kira J Weissman; Máire C Timoney; Mark Bycroft; P Grice; U Hanefeld; James Staunton; Peter F Leadlay
The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase.
Biochemistry 1997;36(45):13849-55.
1997: Mark Bycroft; Tim Hubbard; M Proctor; Stefan M V Freund; Alexey G Murzin
The solution structure of the S1 RNA binding domain: a member of an ancient nucleic acid-binding fold.
Cell 1997;88(2):235-42.
1996: S Fong; Stefan J Hamill; Mark R Proctor; Stefan M V Freund; G M Benian; C Chothia; Mark Bycroft; Jane Clarke
Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans.
Journal of molecular biology 1996;264(3):624-39.
1996: Y K Mok; Mark Bycroft; Gonzalo De Prat-Gay
The dimeric DNA binding domain of the human papillomavirus E2 protein folds through a monomeric intermediate which cannot be native-like.
Nature structural biology 1996;3(8):711-7.
1996: Y K Mok; Gonzalo De Prat-Gay; P J Butler; Mark Bycroft
Equilibrium dissociation and unfolding of the dimeric human papillomavirus strain-16 E2 DNA-binding domain.
Protein science : a publication of the Protein Society 1996;5(2):310-9.
1995: Vickery Arcus; S Vuilleumier; Stefan M V Freund; Mark Bycroft; Alan Fersht
A comparison of the pH, urea, and temperature-denatured states of barnase by heteronuclear NMR: implications for the initiation of protein folding.
Journal of molecular biology 1995;254(2):305-21.
1995: Mark Bycroft; stefan gruenert; Alexey G Murzin; Mark R Proctor; Daniel St Johnston
NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5.
The EMBO journal 1995;14(14):3563-71.
1995: Mark Bycroft; Mark R Proctor; Stefan M V Freund; Daniel St Johnston
Assignment of the backbone 1H,15N,13C NMR resonances and secondary structure of a double-stranded RNA binding domain from the Drosophila protein staufen.
FEBS letters 1995;362(3):333-6.
1994: Vickery Arcus; S Vuilleumier; Stefan M V Freund; Mark Bycroft; Alan Fersht
Toward solving the folding pathway of barnase: the complete backbone 13C, 15N, and 1H NMR assignments of its pH-denatured state.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9412-6.
1994: M J Lubienski; Mark Bycroft; Stefan M V Freund; Alan Fersht
Three-dimensional solution structure and 13C assignments of barstar using nuclear magnetic resonance spectroscopy.
Biochemistry 1994;33(30):8866-77.
1993: J Clarke; A M Hounslow; Mark Bycroft; Alan Fersht
Local breathing and global unfolding in hydrogen exchange of barnase and its relationship to protein folding pathways.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):9837-41.
1993: T E Gray; J Eder; Mark Bycroft; A G Day; Alan Fersht
Refolding of barnase mutants and pro-barnase in the presence and absence of GroEL.
The EMBO journal 1993;12(11):4145-50.
1993: E M Meiering; Mark Bycroft; M J Lubienski; Alan Fersht
Structure and dynamics of barnase complexed with 3'-GMP studied by NMR spectroscopy.
Biochemistry 1993;32(41):10975-87.
1993: M J Lubienski; Mark Bycroft; D N Jones; Alan Fersht
Assignment of the backbone 1H and 15N NMR resonances and secondary structure characterization of barstar.
FEBS letters 1993;332(1-2):81-7.
1993: D N Jones; Mark Bycroft; M J Lubienski; Alan Fersht
Identification of the barstar binding site of barnase by NMR spectroscopy and hydrogen-deuterium exchange.
FEBS letters 1993;331(1-2):165-72.
1992: A Matouschek; L Serrano; E M Meiering; Mark Bycroft; Alan Fersht
The folding of an enzyme. V. H/2H exchange-nuclear magnetic resonance studies on the folding pathway of barnase: complementarity to and agreement with protein engineering studies.
Journal of molecular biology 1992;224(3):837-45.
1991: E M Meiering; Mark Bycroft; Alan Fersht
Characterization of phosphate binding in the active site of barnase by site-directed mutagenesis and NMR.
Biochemistry 1991;30(47):11348-56.
1991: Mark Bycroft; S Ludvigsen; Alan Fersht; Flemming M Poulsen
Determination of the three-dimensional solution structure of barnase using nuclear magnetic resonance spectroscopy.
Biochemistry 1991;30(35):8697-701.
1991: D Sali; Mark Bycroft; Alan Fersht
Surface electrostatic interactions contribute little of stability of barnase.
Journal of molecular biology 1991;220(3):779-88.
1991: Alan Fersht; Mark Bycroft; A Horovitz; J T Kellis; A Matouschek; L Serrano
Pathway and stability of protein folding.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1991;332(1263):171-6.
1991: L Serrano; Mark Bycroft; Alan Fersht
Aromatic-aromatic interactions and protein stability. Investigation by double-mutant cycles.
Journal of molecular biology 1991;218(2):465-75.
1990: A Horovitz; L Serrano; B Avron; Mark Bycroft; Alan Fersht
Strength and co-operativity of contributions of surface salt bridges to protein stability.
Journal of molecular biology 1990;216(4):1031-44.
1990: L Serrano; A Horovitz; B Avron; Mark Bycroft; Alan Fersht
Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles.
Biochemistry 1990;29(40):9343-52.
1990: Mark Bycroft; R N Sheppard; F T Lau; Alan Fersht
Sequential assignment of the 1H nuclear magnetic resonance spectrum of barnase.
Biochemistry 1990;29(32):7425-32.
1990: Mark Bycroft; A Matouschek; J T Kellis; L Serrano; Alan Fersht
Detection and characterization of a folding intermediate in barnase by NMR.
Nature 1990;346(6283):488-90.
1990: A Matouschek; J T Kellis; L Serrano; Mark Bycroft; Alan Fersht
Transient folding intermediates characterized by protein engineering.
Nature 1990;346(6283):440-5.
1988: D Sali; Mark Bycroft; Alan Fersht
Stabilization of protein structure by interaction of alpha-helix dipole with a charged side chain.
Nature 1988;335(6192):740-3.
1988: Mark Bycroft; Alan Fersht
Assignment of histidine resonances in the 1H NMR (500 MHz) spectrum of subtilisin BPN' using site-directed mutagenesis.
Biochemistry 1988;27(19):7390-4.