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Ivona Kozieradzki

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Jennifer D Artz; Irene Chau; Oleg Fedorov; Patrick J Finerty; Tom Heightman; Abdellah Allali-Hassani; Mehrnaz Amani; Ashley Hutchinson; Oliver King; Ivona Kozieradzki; Jocelyne Lew; Yu-Hui Lin; Vlad V Lunin; Farrell Mackenzie; Wei Qiu; Annette Roos; Matthieu Schapira; Guillermo Senisterra; Kevan Shokat; Masoud Vedadi; Frank von Delft; Gregory A Wasney; Amy K Wernimont; Chao Zhang; Yong Zhao; Raymond Hui
The Cryptosporidium parvum kinome.
Feng Liu; Xin Chen; Abdellah Allali-Hassani; Amy M Quinn; Gregory A Wasney; Aiping Dong; Dalia Barsyte; Ivona Kozieradzki; Guillermo Senisterra; Irene Chau; Alena Siarheyeva; Dmitri Kireev; Ajit Jadhav; J Martin Herold; Stephen Frye; Cheryl H Arrowsmith; Peter J Brown; Anton Simeonov; Masoud Vedadi; Jian Jin
Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
Masoud Vedadi; Jocelyne Lew; Jennifer Artz; Mehrnaz Amani; Yong Zhao; Aiping Dong; Gregory A Wasney; Mian Gao; Tanya Hills; Stephen Brokx; Wei Qiu; Sujata Sharma; Angelina Diassiti; Zahoor Alam; Michelle Melone; Anne Mulichak; Amy Wernimont; James Bray; Peter Loppnau; Olga Plotnikova; Kate Newberry; Emayavaram Sundararajan; Simon Houston; John Walker; Wolfram Tempel; Alexey Bochkarev; Ivona Kozieradzki; Aled Edwards; Cheryl Arrowsmith; David Roos; Kevin Kain; Raymond Hui
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.

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All Publications

2011: Jennifer D Artz; Irene Chau; Oleg Fedorov; Patrick J Finerty; Tom Heightman; Abdellah Allali-Hassani; Mehrnaz Amani; Ashley Hutchinson; Oliver King; Ivona Kozieradzki; Jocelyne Lew; Yu-Hui Lin; Vlad V Lunin; Farrell Mackenzie; Wei Qiu; Annette Roos; Matthieu Schapira; Guillermo Senisterra; Kevan Shokat; Masoud Vedadi; Frank von Delft; Gregory A Wasney; Amy K Wernimont; Chao Zhang; Yong Zhao; Raymond Hui
The Cryptosporidium parvum kinome.
BMC genomics 2011;12():478.
2009: Feng Liu; Xin Chen; Abdellah Allali-Hassani; Amy M Quinn; Gregory A Wasney; Aiping Dong; Dalia Barsyte; Ivona Kozieradzki; Guillermo Senisterra; Irene Chau; Alena Siarheyeva; Dmitri Kireev; Ajit Jadhav; J Martin Herold; Stephen Frye; Cheryl H Arrowsmith; Peter J Brown; Anton Simeonov; Masoud Vedadi; Jian Jin
Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
Journal of medicinal chemistry 2009;52(24):7950-3.
2007: Masoud Vedadi; Jocelyne Lew; Jennifer Artz; Mehrnaz Amani; Yong Zhao; Aiping Dong; Gregory A Wasney; Mian Gao; Tanya Hills; Stephen Brokx; Wei Qiu; Sujata Sharma; Angelina Diassiti; Zahoor Alam; Michelle Melone; Anne Mulichak; Amy Wernimont; James Bray; Peter Loppnau; Olga Plotnikova; Kate Newberry; Emayavaram Sundararajan; Simon Houston; John Walker; Wolfram Tempel; Alexey Bochkarev; Ivona Kozieradzki; Aled Edwards; Cheryl Arrowsmith; David Roos; Kevin Kain; Raymond Hui
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Molecular and biochemical parasitology 2007;151(1):100-10.
2006: D Holstead Jones; Tomoki Nakashima; Otto H Sanchez; Ivona Kozieradzki; Svetlana V Komarova; Ildiko Sarosi; Sean Morony; Evelyn Rubin; Renu Sarao; Carlo V Hojilla; Vukoslav Komnenovic; Young-Yun Kong; Martin Schreiber; S Jeffrey Dixon; Stephen M Sims; Rama Khokha; Teiji Wada; Josef M Penninger
Regulation of cancer cell migration and bone metastasis by RANKL.
Nature 2006;440(7084):692-6.
2004: Teiji Wada; Nicholas Joza; Hai-Ying M Cheng; Takehiko Sasaki; Ivona Kozieradzki; Kurt Bachmaier; Toshiaki Katada; Martin Schreiber; Erwin F Wagner; Hiroshi Nishina; Josef M Penninger
MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.
Nature cell biology 2004;6(3):215-26.
2003: Gavin Y Oudit; Michael A Crackower; Urs Eriksson; Renu Sarao; Ivona Kozieradzki; Takehiko Sasaki; Junko Irie-Sasaki; Dominica Gidrewicz; Vitalyi O Rybin; Teiji Wada; Susan F Steinberg; Peter H Backx; Josef M Penninger
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.
Circulation 2003;108(17):2147-52.
2003: Hiromitsu Hara; Teiji Wada; Christopher Bakal; Ivona Kozieradzki; Shinobu Suzuki; Nobutaka Suzuki; Mai Nghiem; Emily K Griffiths; Connie M Krawczyk; Birgit Bauer; Fulvio D'Acquisto; Sankar Ghosh; Wen-Chen Yeh; Gottfried Baier; Robert Rottapel; Josef M Penninger
The MAGUK family protein CARD11 is essential for lymphocyte activation.
Immunity 2003;18(6):763-75.
2003: Michael A Crackower; Nadine K Kolas; Junko Noguchi; Renu Sarao; Kazuhiro Kikuchi; Hiroyuki Kaneko; Eiji Kobayashi; Yasuhiro Kawai; Ivona Kozieradzki; Rushin Landers; Rong Mo; Chi-Chung Hui; Edward Nieves; Paula E Cohen; Lucy Osborne; Teiji Wada; Tetsuo Kunieda; Peter B Moens; Josef M Penninger
Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.
Science (New York, N.Y.) 2003;300(5623):1291-5.
2002: Michael A Crackower; Gavin Y Oudit; Ivona Kozieradzki; Renu Sarao; Hui Sun; Takehiko Sasaki; Emilio Hirsch; Akira Suzuki; Tetsuo Shioi; Junko Irie-Sasaki; Rajan Sah; Hai-Ying M Cheng; Vitalyi O Rybin; Giuseppe Lembo; Luigi Fratta; Antonio J Oliveira-dos-Santos; Jeffery L Benovic; C Ronald Kahn; Seigo Izumo; Susan F Steinberg; Matthias P Wymann; Peter H Backx; Josef M Penninger
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.
Cell 2002;110(6):737-49.
2002: Michael A Crackower; Renu Sarao; Gavin Y Oudit; Chana Yagil; Ivona Kozieradzki; Sam E Scanga; Antonio J Oliveira-dos-Santos; Joan da Costa; Liyong Zhang; York Pei; James Scholey; Carlos M Ferrario; Armen S Manoukian; Mark C Chappell; Peter H Backx; Yoram Yagil; Josef M Penninger
Angiotensin-converting enzyme 2 is an essential regulator of heart function.
Nature 2002;417(6891):822-8.
2001: Emily K Griffiths; Connie M Krawczyk; Young-Yun Kong; M Raab; Sharon J Hyduk; Denis Bouchard; Vera S F Chan; Ivona Kozieradzki; Antonio J Oliveira-dos-Santos; Andrew Wakeham; Pamela S Ohashi; Myron I Cybulsky; C E Rudd; Josef M Penninger
Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap.
Science (New York, N.Y.) 2001;293(5538):2260-3.
2000: Connie M Krawczyk; Kurt Bachmaier; T Sasaki; Russell G Jones; S B Snapper; Denis Bouchard; Ivona Kozieradzki; Pamela S Ohashi; F W Alt; Josef M Penninger
Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells.
Immunity 2000;13(4):463-73.
2000: Peter Liu; Karen Aitken; Y Y Kong; Mary Anne Opavsky; Tami Martino; Fayez Dawood; Wen-Hu Wen; Ivona Kozieradzki; Kurt Bachmaier; D Straus; T W Mak; Josef M Penninger
The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease.
Nature medicine 2000;6(4):429-34.
2000: Takehiko Sasaki; Junko Irie-Sasaki; Russell G Jones; Antonio J Oliveira-dos-Santos; William L Stanford; B Bolon; Andrew Wakeham; Annick Itie; Denis Bouchard; Ivona Kozieradzki; Nicholas Joza; Tak W Mak; Pamela S Ohashi; Akira Suzuki; Josef M Penninger
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration.
Science (New York, N.Y.) 2000;287(5455):1040-6.
2000: Kurt Bachmaier; Connie M Krawczyk; Ivona Kozieradzki; Young-Yun Kong; Takehiko Sasaki; Antonio J Oliveira-dos-Santos; Sanjeev Mariathasan; Denis Bouchard; Andrew Wakeham; Annick Itie; J Le; Pamela S Ohashi; Ildiko Sarosi; Hiroshi Nishina; Stan Lipkowitz; Josef M Penninger
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.
Nature 2000;403(6766):211-6.
1999: Jinyi Zhang; Amro Shehabeldin; L A da Cruz; J Butler; AK Somani; Mary K H McGavin; Ivona Kozieradzki; A O dos Santos; Andras Nagy; Sergio Grinstein; Josef M Penninger; Katherine A Siminovitch
Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes.
The Journal of experimental medicine 1999;190(9):1329-42.
1999: Q Khan; Josef M Penninger; L Yang; L E Marra; Ivona Kozieradzki; Li Zhang
Regulation of apoptosis in mature alphabeta+CD4-CD8- antigen-specific suppressor T cell clones.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5860-7.
1999: Josef M Penninger; Klaus-Dieter Fischer; Takehiko Sasaki; Ivona Kozieradzki; J Le; Kerry Tedford; Kurt Bachmaier; Pamela S Ohashi; Martin F Bachmann
The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation.
European journal of immunology 1999;29(5):1709-18.
1999: Q Liu; T Sasaki; Ivona Kozieradzki; Andrew Wakeham; Annick Itie; Daniel J Dumont; Josef M Penninger
SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival.
Genes & development 1999;13(7):786-91.
1999: Anne Hakem; Takehiko Sasaki; Ivona Kozieradzki; Josef M Penninger
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
The Journal of experimental medicine 1999;189(6):957-68.
1998: Young-Yun Kong; Klaus-Dieter Fischer; Martin F Bachmann; Sanjeev Mariathasan; Ivona Kozieradzki; Mai Nghiem; Denis Bouchard; alan bernstein; Pamela S Ohashi; Josef M Penninger
Vav regulates peptide-specific apoptosis in thymocytes.
The Journal of experimental medicine 1998;188(11):2099-111.
1998: Q Liu; Antonio J Oliveira-dos-Santos; Sanjeev Mariathasan; Denis Bouchard; J Jones; Renu Sarao; Ivona Kozieradzki; Pamela S Ohashi; Josef M Penninger; Daniel J Dumont
The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling.
The Journal of experimental medicine 1998;188(7):1333-42.
1998: Hiroshi Nishina; LG Radvanyi; K Raju; Takehiko Sasaki; Ivona Kozieradzki; Josef M Penninger
Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(7):3416-20.
1998: Richard Boyd; Ivona Kozieradzki; Ann P Chidgey; HW Mittrücker; Denis Bouchard; E Timms; K Kishihara; Christopher J Ong; Daniel Chui; Jamey D Marth; Tak W Mak; Josef M Penninger
Receptor-specific allelic exclusion of TCRV alpha-chains during development.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1718-27.
1998: Klaus-Dieter Fischer; Young-Yun Kong; Hiroshi Nishina; Kerry Tedford; LE Marengère; Ivona Kozieradzki; Takehiko Sasaki; M Starr; G Chan; S Gardener; Mai Nghiem; Denis Bouchard; M Barbacid; alan bernstein; Josef M Penninger
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor.
Current biology : CB 1998;8(10):554-62.
1997: Hiroshi Nishina; M Bachmann; Antonio J Oliveira-dos-Santos; Ivona Kozieradzki; Klaus-Dieter Fischer; Bernhard Odermatt; Andrew Wakeham; Arda Shahinian; H Takimoto; alan bernstein; Tak W Mak; James R Woodgett; Pamela S Ohashi; Josef M Penninger
Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.
The Journal of experimental medicine 1997;186(6):941-53.
1997: Josef M Penninger; C Sirard; HW Mittrücker; Ann P Chidgey; Ivona Kozieradzki; Mai Nghiem; Anne Hakem; T Kimura; E Timms; R Boyd; T Taniguchi; Takeshi Matsuyama; Tak W Mak
The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes.
Immunity 1997;7(2):243-54.
1997: LE Marengère; Christine Mirtsos; Ivona Kozieradzki; André Veillette; Tak W Mak; Josef M Penninger
Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):70-6.
1997: Ivona Kozieradzki; TM Kündig; K Kishihara; Christopher J Ong; D Chiu; V A Wallace; K Kawai; E Timms; J Ionescu; Pamela S Ohashi; Jamey D Marth; Tak W Mak; Josef M Penninger
T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3130-9.
1997: Kurt Bachmaier; CL Pummerer; Ivona Kozieradzki; K Pfeffer; Tak W Mak; N Neu; Josef M Penninger
Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease.
Circulation 1997;95(3):655-61.
1993: M Clelia Ganoza; Hiroyuki Aoki; Ivona Kozieradzki; I Schwartz
Reconstruction of translation. Evidence for the involvement of the rescue protein in the association/dissociation of ribosomal subunits.
European journal of biochemistry / FEBS 1993;217(3):839-47.