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Dennis Ohman

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Irina S Barequet; Nirit Bourla; Dennis Ohman; Yuval N Pessach; Mordechai Rosner; Mary Safrin; Dalit Yankovich; Efrat Kessler
Staphylolysin is an effective therapeutic agent for Staphylococcus aureus experimental keratitis.
Souvik Chakrabarty; Allison King; Pinar Kurt; Wei Zhang; Dennis Ohman; Lynn F Wood; C Lovelace; Raj Rao; Raj Rao
Highly effective, water-soluble, hemocompatible 1,3-propylene oxide-based antimicrobials: poly[(3,3-quaternary/PEG)-copolyoxetanes].
Laura Silo-Suh; Brett Elmore; Dennis Ohman; Sang-Jin Suh
Isolation, characterization, and utilization of a temperature-sensitive allele of a Pseudomonas replicon.

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All Publications

2012: Irina S Barequet; Nirit Bourla; Dennis Ohman; Yuval N Pessach; Mordechai Rosner; Mary Safrin; Dalit Yankovich; Efrat Kessler
Staphylolysin is an effective therapeutic agent for Staphylococcus aureus experimental keratitis.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2012;250(2):223-9.
2011: Souvik Chakrabarty; Allison King; Pinar Kurt; Wei Zhang; Dennis Ohman; Lynn F Wood; C Lovelace; Raj Rao; Raj Rao
Highly effective, water-soluble, hemocompatible 1,3-propylene oxide-based antimicrobials: poly[(3,3-quaternary/PEG)-copolyoxetanes].
Biomacromolecules 2011;12(3):757-69.
2009: Laura Silo-Suh; Brett Elmore; Dennis Ohman; Sang-Jin Suh
Isolation, characterization, and utilization of a temperature-sensitive allele of a Pseudomonas replicon.
Journal of microbiological methods 2009;78(3):319-24.
2009: Zhe-Xue Lu; Lynn F Wood; Dennis Ohman; Maryanne M Collinson
Bio-inspired chemical reactors for growing aligned gold nanoparticle-like wires.
Chemical communications (Cambridge, England) 2009;(28):4200-2.
2009: Irina S Barequet; Zohar Habot-Wilner; Oran Mann; Mary Safrin; Dennis Ohman; Efrat Kessler; Mordechai Rosner
Evaluation of Pseudomonas aeruginosa staphylolysin (LasA protease) in the treatment of methicillin-resistant Staphylococcus aureus endophthalmitis in a rat model.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie 2009;247(7):913-7.
2009: Lynn F Wood; Dennis Ohman
Use of cell wall stress to characterize sigma 22 (AlgT/U) activation by regulated proteolysis and its regulon in Pseudomonas aeruginosa.
Molecular microbiology 2009;72(1):183-201.
2008: Lashanda L Oglesby; Sumita Jain; Dennis Ohman
Membrane topology and roles of Pseudomonas aeruginosa Alg8 and Alg44 in alginate polymerization.
Microbiology (Reading, England) 2008;154(Pt 6):1605-15.
2008: Andrew J Leech; April B Sprinkle; Lynn Wood; Daniel J Wozniak; Dennis Ohman
The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.
Journal of bacteriology 2008;190(2):581-9.
2007: Kerian K Grande; Jean K Gustin; Efrat Kessler; Dennis Ohman
Identification of critical residues in the propeptide of LasA protease of Pseudomonas aeruginosa involved in the formation of a stable mature protease.
Journal of bacteriology 2007;189(11):3960-8.
2007: Pinar Kurt; Lynn Wood; Dennis Ohman; Raj Rao
Highly effective contact antimicrobial surfaces via polymer surface modifiers.
Langmuir : the ACS journal of surfaces and colloids 2007;23(9):4719-23.
2006: Lynn F Wood; Andrew J Leech; Dennis Ohman
Cell wall-inhibitory antibiotics activate the alginate biosynthesis operon in Pseudomonas aeruginosa: Roles of sigma (AlgT) and the AlgW and Prc proteases.
Molecular microbiology 2006;62(2):412-26.
2006: Lynn F Wood; Dennis Ohman
Independent regulation of MucD, an HtrA-like protease in Pseudomonas aeruginosa, and the role of its proteolytic motif in alginate gene regulation.
Journal of bacteriology 2006;188(8):3134-7.
2006: Umit Makal; Lynn Wood; Dennis Ohman; Raj Rao
Polyurethane biocidal polymeric surface modifiers.
Biomaterials 2006;27(8):1316-26.
2005: Laura Silo-Suh; Sang-Jin Suh; Paul V Phibbs; Dennis Ohman
Adaptations of Pseudomonas aeruginosa to the cystic fibrosis lung environment can include deregulation of zwf, encoding glucose-6-phosphate dehydrogenase.
Journal of bacteriology 2005;187(22):7561-8.
2005: Sumita Jain; Dennis Ohman
Role of an alginate lyase for alginate transport in mucoid Pseudomonas aeruginosa.
Infection and immunity 2005;73(10):6429-36.
2005: Stephanie A Douthit; Mensur Dlakic; Dennis Ohman; Michael J Franklin
Epimerase active domain of Pseudomonas aeruginosa AlgG, a protein that contains a right-handed beta-helix.
Journal of bacteriology 2005;187(13):4573-83.
2005: Chun-Chiang Chen; Lieke Riadi; Sang-Jin Suh; Dennis Ohman; Lu-Kwang Ju
Degradation and synthesis kinetics of quorum-sensing autoinducer in Pseudomonas aeruginosa cultivation.
Journal of biotechnology 2005;117(1):1-10.
2004: Kevin S. McIver; Efrat Kessler; Dennis Ohman
Identification of residues in the Pseudomonas aeruginosa elastase propeptide required for chaperone and secretion activities.
Microbiology (Reading, England) 2004;150(Pt 12):3969-77.
2004: Sang-Jin Suh; Laura Silo-Suh; Dennis Ohman
Development of tools for the genetic manipulation of Pseudomonas aeruginosa.
Journal of microbiological methods 2004;58(2):203-12.
2004: Andres Plata Stapper; Giri Narasimhan; Dennis Ohman; Johnny Barakat; Morten Hentzer; Søren Molin; Arsalan Kharazmi; Niels Høiby; Kalai Mathee
Alginate production affects Pseudomonas aeruginosa biofilm development and architecture, but is not essential for biofilm formation.
Journal of medical microbiology 2004;53(Pt 7):679-90.
2004: Efrat Kessler; Mary Safrin; Shmaryahu Blumberg; Dennis Ohman
A continuous spectrophotometric assay for Pseudomonas aeruginosa LasA protease (staphylolysin) using a two-stage enzymatic reaction.
Analytical biochemistry 2004;328(2):225-32.
2004: Irina S Barequet; Guy J Ben-Simon; Mary Safrin; Dennis Ohman; Efrat Kessler
Pseudomonas aeruginosa LasA protease in treatment of experimental staphylococcal keratitis.
Antimicrobial agents and chemotherapy 2004;48(5):1681-7.
2003: Steve P Bernier; Laura Silo-Suh; Donald E Woods; Dennis Ohman; Pamela A Sokol
Comparative analysis of plant and animal models for characterization of Burkholderia cepacia virulence.
Infection and immunity 2003;71(9):5306-13.
2003: Martin Gimmestad; Håvard Sletta; Helga Ertesvåg; Karianne Bakkevig; Sumita Jain; Sang-Jin Suh; Gudmund Skjåk-Braek; Trond E Ellingsen; Dennis Ohman; Svein Valla
The Pseudomonas fluorescens AlgG protein, but not its mannuronan C-5-epimerase activity, is needed for alginate polymer formation.
Journal of bacteriology 2003;185(12):3515-23.
2003: Sumita Jain; Michael J Franklin; Helga Ertesvåg; Svein Valla; Dennis Ohman
The dual roles of AlgG in C-5-epimerization and secretion of alginate polymers in Pseudomonas aeruginosa.
Molecular microbiology 2003;47(4):1123-33.
2002: Laura Silo-Suh; Sang-Jin Suh; Pamela A Sokol; Dennis Ohman
A simple alfalfa seedling infection model for Pseudomonas aeruginosa strains associated with cystic fibrosis shows AlgT (sigma-22) and RhlR contribute to pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15699-704.
2002: Michael J Franklin; Dennis Ohman
Mutant analysis and cellular localization of the AlgI, AlgJ, and AlgF proteins required for O acetylation of alginate in Pseudomonas aeruginosa.
Journal of bacteriology 2002;184(11):3000-7.
2001: R Cahan; I Axelrad; Mary Safrin; Dennis Ohman; Efrat Kessler
A secreted aminopeptidase of Pseudomonas aeruginosa. Identification, primary structure, and relationship to other aminopeptidases.
The Journal of biological chemistry 2001;276(47):43645-52.
2001: A Morea; Kalai Mathee; Michael J Franklin; Alessio Giacomini; M O'Regan; Dennis Ohman
Characterization of algG encoding C5-epimerase in the alginate biosynthetic gene cluster of Pseudomonas fluorescens.
Gene 2001;278(1-2):107-14.
2001: Gerald B Pier; Fadie T Coleman; Martha Grout; M Franklin; Dennis Ohman
Role of alginate O acetylation in resistance of mucoid Pseudomonas aeruginosa to opsonic phagocytosis.
Infection and immunity 2001;69(3):1895-901.
2001: David E Nivens; Dennis Ohman; J Williams; Michael J Franklin
Role of alginate and its O acetylation in formation of Pseudomonas aeruginosa microcolonies and biofilms.
Journal of bacteriology 2001;183(3):1047-57.
2000: S Malhotra; Laura Silo-Suh; Kalai Mathee; Dennis Ohman
Proteome analysis of the effect of mucoid conversion on global protein expression in Pseudomonas aeruginosa strain PAO1 shows induction of the disulfide bond isomerase, dsbA.
Journal of bacteriology 2000;182(24):6999-7006.
1999: Sang-Jin Suh; Laura Silo-Suh; Donald E Woods; Daniel J Hassett; Susan E H West; Dennis Ohman
Effect of rpoS mutation on the stress response and expression of virulence factors in Pseudomonas aeruginosa.
Journal of bacteriology 1999;181(13):3890-7.
1999: Kalai Mathee; Oana Ciofu; Claus Sternberg; PW Lindum; Joan I A Campbell; P Jensen; A H Johnsen; Michael Givskov; Dennis Ohman; Søren Molin; Niels Høiby; Arsalan Kharazmi
Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung.
Microbiology (Reading, England) 1999;145 ( Pt 6)():1349-57.
1998: Efrat Kessler; Mary Safrin; Jean K Gustin; Dennis Ohman
Elastase and the LasA protease of Pseudomonas aeruginosa are secreted with their propeptides.
The Journal of biological chemistry 1998;273(46):30225-31.
1998: S Ma; U Selvaraj; Dennis Ohman; R Quarless; Daniel J Hassett; D J Wozniak
Phosphorylation-independent activity of the response regulators AlgB and AlgR in promoting alginate biosynthesis in mucoid Pseudomonas aeruginosa.
Journal of bacteriology 1998;180(4):956-68.
1998: S Jain; Dennis Ohman
Deletion of algK in mucoid Pseudomonas aeruginosa blocks alginate polymer formation and results in uronic acid secretion.
Journal of bacteriology 1998;180(3):634-41.
1997: Michael Preston; PC Seed; Debbie Sue Toder; Barbara H Iglewski; Dennis Ohman; Jean K Gustin; J B Goldberg; Gerald B Pier
Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections.
Infection and immunity 1997;65(8):3086-90.
1997: S Ma; D J Wozniak; Dennis Ohman
Identification of the histidine protein kinase KinB in Pseudomonas aeruginosa and its phosphorylation of the alginate regulator algB.
The Journal of biological chemistry 1997;272(29):17952-60.
1997: Kalai Mathee; C J McPherson; Dennis Ohman
Posttranslational control of the algT (algU)-encoded sigma22 for expression of the alginate regulon in Pseudomonas aeruginosa and localization of its antagonist proteins MucA and MucB (AlgN).
Journal of bacteriology 1997;179(11):3711-20.
1997: Efrat Kessler; Mary Safrin; William Abrams; Joel Rosenbloom; Dennis Ohman
Inhibitors and specificity of Pseudomonas aeruginosa LasA.
The Journal of biological chemistry 1997;272(15):9884-9.
1996: J K Gustin; Efrat Kessler; Dennis Ohman
A substitution at His-120 in the LasA protease of Pseudomonas aeruginosa blocks enzymatic activity without affecting propeptide processing or extracellular secretion.
Journal of bacteriology 1996;178(22):6608-17.
1996: M J Franklin; Dennis Ohman
Identification of algI and algJ in the Pseudomonas aeruginosa alginate biosynthetic gene cluster which are required for alginate O acetylation.
Journal of bacteriology 1996;178(8):2186-95.
1995: Kevin S. McIver; Efrat Kessler; Joan C Olson; Dennis Ohman
The elastase propeptide functions as an intramolecular chaperone required for elastase activity and secretion in Pseudomonas aeruginosa.
Molecular microbiology 1995;18(5):877-89.
1995: J M Brint; Dennis Ohman
Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family.
Journal of bacteriology 1995;177(24):7155-63.
1995: Daniel J Hassett; H P Schweizer; Dennis Ohman
Pseudomonas aeruginosa sodA and sodB mutants defective in manganese- and iron-cofactored superoxide dismutase activity demonstrate the importance of the iron-cofactored form in aerobic metabolism.
Journal of bacteriology 1995;177(22):6330-7.
1995: C A DeVries; Daniel J Hassett; J L Flynn; Dennis Ohman
Genetic linkage in Pseudomonas aeruginosa of algT and nadB: mutation in nadB does not affect NAD biosynthesis or alginate production.
Gene 1995;156(1):63-7.
1995: K Kabha; L Nissimov; A Athamna; Yona Keisari; Haralambos Parolis; Lesley A S Parolis; R M Grue; J Schlepper-Schafer; A R Ezekowitz; Dennis Ohman
Relationships among capsular structure, phagocytosis, and mouse virulence in Klebsiella pneumoniae.
Infection and immunity 1995;63(3):847-52.
1994: C A DeVries; Dennis Ohman
Mucoid-to-nonmucoid conversion in alginate-producing Pseudomonas aeruginosa often results from spontaneous mutations in algT, encoding a putative alternate sigma factor, and shows evidence for autoregulation.
Journal of bacteriology 1994;176(21):6677-87.
1994: Daniel J Wozniak; Dennis Ohman
Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT.
Journal of bacteriology 1994;176(19):6007-14.
1994: M J Franklin; C E Chitnis; P Gacesa; A Sonesson; D C White; Dennis Ohman
Pseudomonas aeruginosa AlgG is a polymer level alginate C5-mannuronan epimerase.
Journal of bacteriology 1994;176(7):1821-30.
1994: Evgeni V Sokurenko; Harry S Courtney; Dennis Ohman; P Klemm; David L Hasty
FimH family of type 1 fimbrial adhesins: functional heterogeneity due to minor sequence variations among fimH genes.
Journal of bacteriology 1994;176(3):748-55.
1993: Daniel J Hassett; W A Woodruff; Daniel J Wozniak; Michael Vasil; M S Cohen; Dennis Ohman
Cloning and characterization of the Pseudomonas aeruginosa sodA and sodB genes encoding manganese- and iron-cofactored superoxide dismutase: demonstration of increased manganese superoxide dismutase activity in alginate-producing bacteria.
Journal of bacteriology 1993;175(23):7658-65.
1993: Itzhak Ofek; K Kabha; A Athamna; G Frankel; D J Wozniak; David L Hasty; Dennis Ohman
Genetic exchange of determinants for capsular polysaccharide biosynthesis between Klebsiella pneumoniae strains expressing serotypes K2 and K21a.
Infection and immunity 1993;61(10):4208-16.
1993: M J Franklin; Dennis Ohman
Identification of algF in the alginate biosynthetic gene cluster of Pseudomonas aeruginosa which is required for alginate acetylation.
Journal of bacteriology 1993;175(16):5057-65.
1993: Neal L Schiller; S R Monday; C M Boyd; Noel T Keen; Dennis Ohman
Characterization of the Pseudomonas aeruginosa alginate lyase gene (algL): cloning, sequencing, and expression in Escherichia coli.
Journal of bacteriology 1993;175(15):4780-9.
1993: Daniel J Wozniak; Dennis Ohman
Involvement of the alginate algT gene and integration host factor in the regulation of the Pseudomonas aeruginosa algB gene.
Journal of bacteriology 1993;175(13):4145-53.
1993: Kevin S. McIver; Joan C Olson; Dennis Ohman
Pseudomonas aeruginosa lasB1 mutants produce an elastase, substituted at active-site His-223, that is defective in activity, processing, and secretion.
Journal of bacteriology 1993;175(13):4008-15.
1993: C E Chitnis; Dennis Ohman
Genetic analysis of the alginate biosynthetic gene cluster of Pseudomonas aeruginosa shows evidence of an operonic structure.
Molecular microbiology 1993;8(3):583-93.
1993: Efrat Kessler; Mary Safrin; Joan C Olson; Dennis Ohman
Secreted LasA of Pseudomonas aeruginosa is a staphylolytic protease.
The Journal of biological chemistry 1993;268(10):7503-8.
1993: Joanna B Goldberg; W L Gorman; J L Flynn; Dennis Ohman
A mutation in algN permits trans activation of alginate production by algT in Pseudomonas species.
Journal of bacteriology 1993;175(5):1303-8.
1992: Joan C Olson; Dennis Ohman
Efficient production and processing of elastase and LasA by Pseudomonas aeruginosa require zinc and calcium ions.
Journal of bacteriology 1992;174(12):4140-7.
1992: Abdul N Hamood; Dennis Ohman; Susan E H West; Barbara H Iglewski
Isolation and characterization of toxin A excretion-deficient mutants of Pseudomonas aeruginosa PAO1.
Infection and immunity 1992;60(2):510-7.
1992: Daniel J Hassett; L Charniga; K Bean; Dennis Ohman; Myron S Cohen
Response of Pseudomonas aeruginosa to pyocyanin: mechanisms of resistance, antioxidant defenses, and demonstration of a manganese-cofactored superoxide dismutase.
Infection and immunity 1992;60(2):328-36.
1991: Kevin S. McIver; Efrat Kessler; Dennis Ohman
Substitution of active-site His-223 in Pseudomonas aeruginosa elastase and expression of the mutated lasB alleles in Escherichia coli show evidence for autoproteolytic processing of proelastase.
Journal of bacteriology 1991;173(24):7781-9.
1991: Daniel J Wozniak; Dennis Ohman
Pseudomonas aeruginosa AlgB, a two-component response regulator of the NtrC family, is required for algD transcription.
Journal of bacteriology 1991;173(4):1406-13.
1990: C E Chitnis; Dennis Ohman
Cloning of Pseudomonas aeruginosa algG, which controls alginate structure.
Journal of bacteriology 1990;172(6):2894-900.
1990: Joanna B Goldberg; J Won; Dennis Ohman
Precise excision and instability of the transposon Tn5 in Pseudomonas aeruginosa.
Journal of general microbiology 1990;136(5):789-96.
1989: Dennis Ohman; C E Chitnis
Genetic regulation of alginate structure in Pseudomonas aeruginosa.
Antibiotics and chemotherapy 1989;42():56-61.
1988: J M Horn; Dennis Ohman
Autogenous regulation and kinetics of induction of Pseudomonas aeruginosa recA transcription as analyzed with operon fusions.
Journal of bacteriology 1988;170(10):4699-705.
1988: J L Flynn; Dennis Ohman
Use of a gene replacement cosmid vector for cloning alginate conversion genes from mucoid and nonmucoid Pseudomonas aeruginosa strains: algS controls expression of algT.
Journal of bacteriology 1988;170(7):3228-36.
1988: J L Flynn; Dennis Ohman
Cloning of genes from mucoid Pseudomonas aeruginosa which control spontaneous conversion to the alginate production phenotype.
Journal of bacteriology 1988;170(4):1452-60.
1988: J M Horn; Dennis Ohman
Transcriptional and translational analyses of recA mutant alleles in Pseudomonas aeruginosa.
Journal of bacteriology 1988;170(4):1637-50.
1987: Joanna B Goldberg; Dennis Ohman
Activation of an elastase precursor by the lasA gene product of Pseudomonas aeruginosa.
Journal of bacteriology 1987;169(10):4532-9.
1987: Joanna B Goldberg; Dennis Ohman
Construction and characterization of Pseudomonas aeruginosa algB mutants: role of algB in high-level production of alginate.
Journal of bacteriology 1987;169(4):1593-602.
1987: Joanna B Goldberg; Dennis Ohman
Cloning and transcriptional regulation of the elastase lasA gene in mucoid and nonmucoid Pseudomonas aeruginosa.
Journal of bacteriology 1987;169(3):1349-51.
1986: Dennis Ohman
Molecular genetics of exopolysaccharide production by mucoid Pseudomonas aeruginosa.
European journal of clinical microbiology 1986;5(1):6-10.
1985: Dennis Ohman; M A West; J L Flynn; Joanna B Goldberg
Method for gene replacement in Pseudomonas aeruginosa used in construction of recA mutants: recA-independent instability of alginate production.
Journal of bacteriology 1985;162(3):1068-74.
1985: Dennis Ohman; Joanna B Goldberg; J A Flynn; S K Powell
Genetics of exopolysaccharide production by mucoid Pseudomonas aeruginosa.
Antibiotics and chemotherapy 1985;36():13-22.
1984: Joanna B Goldberg; Dennis Ohman
Cloning and expression in Pseudomonas aeruginosa of a gene involved in the production of alginate.
Journal of bacteriology 1984;158(3):1115-21.
1982: Dennis Ohman; Ananda M Chakrabarty
Utilization of human respiratory secretions by mucoid Pseudomonas aeruginosa of cystic fibrosis origin.
Infection and immunity 1982;37(2):662-9.
1981: Dennis Ohman; Ananda M Chakrabarty
Genetic mapping of chromosomal determinants for the production of the exopolysaccharide alginate in a Pseudomonas aeruginosa cystic fibrosis isolate.
Infection and immunity 1981;33(1):142-8.
1980: Dennis Ohman; R P Burns; B H Iglewski
Corneal infections in mice with toxin A and elastase mutants of Pseudomonas aeruginosa.
The Journal of infectious diseases 1980;142(4):547-55.
1980: Dennis Ohman; J C Sadoff; B H Iglewski
Toxin A-deficient mutants of Pseudomonas aeruginosa PA103: isolation and characterization.
Infection and immunity 1980;28(3):899-908.
1980: Dennis Ohman; Stanley J Cryz; B H Iglewski
Isolation and characterization of Pseudomonas aeruginosa PAO mutant that produces altered elastase.
Journal of bacteriology 1980;142(3):836-42.
1979: P A Sokol; Dennis Ohman; B H Iglewski
A more sensitive plate assay for detection of protease production by Pseudomanas aeruginosa.
Journal of clinical microbiology 1979;9(4):538-40.