FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Willy Spaan

Research Profile

Chemicals & Drugs

Living Beings

Concepts & Ideas

Molecular Sequence Data

Genes & Molecular Sequences

Anatomy

Cell Line

Physiology

Procedures

Cloning, Molecular

Co-author Network

Publications

TOP 3
Kalina T Zlateva; Eric C J Claas; Frank E J Coenjaerts; Kelly M Crusio; Margareta Ieven; Christine Lammens; Frank Leus; Willy Spaan; Marco Viveen; Alexander E Gorbalenya
No novel coronaviruses identified in a large collection of human nasopharyngeal specimens using family-wide CODEHOP-based primers.
Olga Slobodskaya; Eric J Snijder; Willy Spaan
Organ tropism of murine coronavirus does not correlate with the expression levels of the membrane-anchored or secreted isoforms of the carcinoembryonic antigen-related cell adhesion molecule 1 receptor.
Kalina T Zlateva; Eric Claas; Kelly M Crusio; Alexander A Kravchenko; Chris Lauber; Andrey M Leontovich; Willy Spaan; Alexander E Gorbalenya
Design and validation of consensus-degenerate hybrid oligonucleotide primers for broad and sensitive detection of corona- and toroviruses.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Willy Spaan (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Kalina T Zlateva; Eric C J Claas; Frank E J Coenjaerts; Kelly M Crusio; Margareta Ieven; Christine Lammens; Frank Leus; Willy Spaan; Marco Viveen; Alexander E Gorbalenya
No novel coronaviruses identified in a large collection of human nasopharyngeal specimens using family-wide CODEHOP-based primers.
Archives of virology 2013;158(1):251-5.
2012: Olga Slobodskaya; Eric J Snijder; Willy Spaan
Organ tropism of murine coronavirus does not correlate with the expression levels of the membrane-anchored or secreted isoforms of the carcinoembryonic antigen-related cell adhesion molecule 1 receptor.
The Journal of general virology 2012;93(Pt 9):1918-23.
2011: Kalina T Zlateva; Eric Claas; Kelly M Crusio; Alexander A Kravchenko; Chris Lauber; Andrey M Leontovich; Willy Spaan; Alexander E Gorbalenya
Design and validation of consensus-degenerate hybrid oligonucleotide primers for broad and sensitive detection of corona- and toroviruses.
Journal of virological methods 2011;177(2):174-83.
2011: Clara C Posthuma; Martha T van der Beek; Caroline S van der Blij-de Brouwer; Pim L J van der Heiden; Erik W A Marijt; Willy Spaan; Eric C J Claas; Christa Nederstigt; Ann C T M Vossen; Eric J Snijder; Aloys C M Kroes
Mass spectrometry-based comparative sequencing to detect ganciclovir resistance in the UL97 gene of human cytomegalovirus.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2011;51(1):25-30.
2010: Patrícia A G C Silva; Carina F Pereira; Tim J Dalebout; Willy Spaan; Peter J Bredenbeek
An RNA pseudoknot is required for production of yellow fever virus subgenomic RNA by the host nuclease XRN1.
Journal of virology 2010;84(21):11395-406.
2010: Jolanda M P Liefhebber; Paul J Hensbergen; André M Deelder; Willy Spaan; Hans C van Leeuwen
Characterization of hepatitis C virus NS3 modifications in the context of replication.
The Journal of general virology 2010;91(Pt 4):1013-8.
2010: Jolanda Mp Liefhebber; Simone Punt; Willy Spaan; Hans C van Leeuwen
The human collagen beta(1-O)galactosyltransferase, GLT25D1, is a soluble endoplasmic reticulum localized protein.
BMC cell biology 2010;11():33.
2009: Jeroen Corver; Rene Broer; Puck van Kasteren; Willy Spaan
Mutagenesis of the transmembrane domain of the SARS coronavirus spike glycoprotein: refinement of the requirements for SARS coronavirus cell entry.
Virology journal 2009;6():230.
2009: Jolanda M P Liefhebber; Bernd W Brandt; Rene Broer; Willy Spaan; Hans C van Leeuwen
Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain.
Virology journal 2009;6():62.
2008: Olga Slobodskaya; Alexander Laarman; Willy Spaan
Intracellular restriction of a productive noncytopathic coronavirus infection.
Journal of virology 2008;82(1):451-60.
2007: Gijs A Versteeg; Paula S van de Nes; Peter J Bredenbeek; Willy Spaan
The coronavirus spike protein induces endoplasmic reticulum stress and upregulation of intracellular chemokine mRNA concentrations.
Journal of virology 2007;81(20):10981-90.
2007: Jeroen Corver; Rene Broer; Puck van Kasteren; Willy Spaan
GxxxG motif of severe acute respiratory syndrome coronavirus spike glycoprotein transmembrane domain is not involved in trimerization and is not important for entry.
Journal of virology 2007;81(15):8352-5.
2007: Patrícia A G C Silva; Richard Molenkamp; Tim J Dalebout; Nathalie Charlier; Johan Neyts; Willy Spaan; Peter J Bredenbeek
Conservation of the pentanucleotide motif at the top of the yellow fever virus 17D 3' stem-loop structure is not required for replication.
The Journal of general virology 2007;88(Pt 6):1738-47.
2007: Gijs A Versteeg; Peter J Bredenbeek; Sjoerd van den Worm; Willy Spaan
Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition.
Virology 2007;361(1):18-26.
2007: Christine Rollier; Glaucia Paranhos-Baccala; Ernst J Verschoor; Babs E Verstrepen; Joost A R Drexhage; Zahra Fagrouch; Jean-Luc Berland; Florence Komurian-Pradel; Blandine Duverger; Nourredine Himoudi; Caroline Staib; Marcus Meyr; Mike Whelan; Joseph A Whelan; Victoria C Adams; Victoria A Adams; Esther Larrea; José I Riezu; Juan José Lasarte; Juan José Lasarte; Birke Bartosch; Francois-L Cosset; Willy Spaan; Helmut M Diepolder; Gerd R Pape; Gerd Sutter; Genevieve Inchauspe; Jonathan Luke Heeney
Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity.
Hepatology (Baltimore, Md.) 2007;45(3):602-13.
2006: Gijs A Versteeg; Olga Slobodskaya; Willy Spaan
Transcriptional profiling of acute cytopathic murine hepatitis virus infection in fibroblast-like cells.
The Journal of general virology 2006;87(Pt 7):1961-75.
2006: Alexander O. Pasternak; Willy Spaan; Eric J Snijder
Nidovirus transcription: how to make sense...?
The Journal of general virology 2006;87(Pt 6):1403-21.
2006: Hans C van Leeuwen; Jolanda M P Liefhebber; Willy Spaan
Repair and polyadenylation of a naturally occurring hepatitis C virus 3' nontranslated region-shorter variant in selectable replicon cell lines.
Journal of virology 2006;80(9):4336-43.
2006: Peter J Bredenbeek; Richard Molenkamp; Willy Spaan; Vincent Deubel; Philippe Marianneau; Maria Salvato; Dmitry Moshkoff; Juan Carlos Zapata; Ilia Tikhonov; Jean L Patterson; Ricardo Carrion; Anysha Ticer; Kathleen M Brasky; Igor S Lukashevich
A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins.
Virology 2006;345(2):299-304.
2006: Rene Broer; Bertrand Boson; Willy Spaan; François-Loïc Cosset; Jeroen Corver
Important role for the transmembrane domain of severe acute respiratory syndrome coronavirus spike protein during entry.
Journal of virology 2006;80(3):1302-10.
2004: Jessika C Zevenhoven-Dobbe; Sophie Greve; Hans Van Tol; Willy Spaan; Eric J Snijder
Rescue of disabled infectious single-cycle (DISC) equine arteritis virus by using complementing cell lines that express minor structural glycoproteins.
The Journal of general virology 2004;85(Pt 12):3709-14.
2004: Alexander O. Pasternak; Willy Spaan; Eric J Snijder
Regulation of relative abundance of arterivirus subgenomic mRNAs.
Journal of virology 2004;78(15):8102-13.
2004: Alexander E Gorbalenya; Eric J Snijder; Willy Spaan
Severe acute respiratory syndrome coronavirus phylogeny: toward consensus.
Journal of virology 2004;78(15):7863-6.
2004: Hans C van Leeuwen; Chantal B E M Reusken; Marko Roeten; Tim J Dalebout; José I Riezu-Boj; Juan Ruiz; Willy Spaan
Evolution of naturally occurring 5' non-translated region variants of hepatitis C virus genotype 1b in selectable replicons.
The Journal of general virology 2004;85(Pt 7):1859-66.
2004: Jan ter Meulen; Alexander B H Bakker; Edward N van den Brink; Gerrit Jan Weverling; Byron Martina; Bart L Haagmans; Thijs Kuiken; John de Kruif; Wolfgang Preiser; Willy Spaan; Hans R Gelderblom; Jaap Goudsmit; Albert D M E Osterhaus
Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets.
Lancet 2004;363(9427):2139-41.
2004: Janke Schinkel; Willy Spaan; Aloys C M Kroes
Meta-analysis of mutations in the NS5A gene and hepatitis C virus resistance to interferon therapy: uniting discordant conclusions.
Antiviral therapy 2004;9(2):275-86.
2004: Aloys C M Kroes; Willy Spaan; E C Claas
[From fowl plague to influenza pandemic; a reason for taking precaution].
Nederlands tijdschrift voor geneeskunde 2004;148(10):458-63.
2003: Janke Schinkel; Menno D De Jong; Bas Bruning; Bart van Hoek; Willy Spaan; Aloys C M Kroes
The potentiating effect of ribavirin on interferon in the treatment of hepatitis C: lack of evidence for ribavirin-induced viral mutagenesis.
Antiviral therapy 2003;8(6):535-40.
2003: Eric J Snijder; Peter J Bredenbeek; Jessika C Dobbe; Volker Thiel; John Ziebuhr; Leo Poon; Yi Guan; Michael Rozanov; Willy Spaan; Alexander E Gorbalenya
Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage.
Journal of molecular biology 2003;331(5):991-1004.
2003: Chantal B E M Reusken; Tim J Dalebout; Peter Eerligh; Peter J Bredenbeek; Willy Spaan
Analysis of hepatitis C virus/classical swine fever virus chimeric 5'NTRs: sequences within the hepatitis C virus IRES are required for viral RNA replication.
The Journal of general virology 2003;84(Pt 7):1761-9.
2003: Mariet C W Feltkamp; René Broer; Franca M di Summa; Linda Struijk; Els van der Meijden; Bert P J Verlaan; Rudi G J Westendorp; Jan ter Schegget; Willy Spaan; Jan N Bouwes Bavinck
Seroreactivity to epidermodysplasia verruciformis-related human papillomavirus types is associated with nonmelanoma skin cancer.
Cancer research 2003;63(10):2695-700.
2003: Peter J Bredenbeek; Engbert A Kooi; Brett Lindenbach; Nicolette Huijkman; Charles M Rice; Willy Spaan
A stable full-length yellow fever virus cDNA clone and the role of conserved RNA elements in flavivirus replication.
The Journal of general virology 2003;84(Pt 5):1261-8.
2003: Richard Molenkamp; Engbert A Kooi; Marjoleine A Lucassen; Sophie Greve; Joyphi C P Thijssen; Willy Spaan; Peter J Bredenbeek
Yellow fever virus replicons as an expression system for hepatitis C virus structural proteins.
Journal of virology 2003;77(2):1644-8.
2003: Alexander O. Pasternak; Erwin van den Born; Willy Spaan; Eric J Snijder
The stability of the duplex between sense and antisense transcription-regulating sequences is a crucial factor in arterivirus subgenomic mRNA synthesis.
Journal of virology 2003;77(2):1175-83.
2003: Eric J Snijder; Jessika C Dobbe; Willy Spaan
Heterodimerization of the two major envelope proteins is essential for arterivirus infectivity.
Journal of virology 2003;77(1):97-104.
2002: Caroline S Brown; Franca M DiSumma; Jean Rommelaere; Alexandra Y Dege; Jan J Cornelis; Christiane Dinsart; Willy Spaan
Production of recombinant H1 parvovirus stocks devoid of replication-competent viruses.
Human gene therapy 2002;13(18):2135-45.
2001: Alexander O. Pasternak; Erwin van den Born; Willy Spaan; Eric J Snijder
Sequence requirements for RNA strand transfer during nidovirus discontinuous subgenomic RNA synthesis.
The EMBO journal 2001;20(24):7220-8.
2001: Jessika C Dobbe; Yvonne van der Meer; Willy Spaan; Eric J Snijder
Construction of chimeric arteriviruses reveals that the ectodomain of the major glycoprotein is not the main determinant of equine arteritis virus tropism in cell culture.
Virology 2001;288(2):283-94.
2001: Rene Rijnbrand; Peter J Bredenbeek; P C Haasnoot; Jeffrey S Kieft; Willy Spaan; Stanley M Lemon
The influence of downstream protein-coding sequence on internal ribosome entry on hepatitis C virus and other flavivirus RNAs.
RNA (New York, N.Y.) 2001;7(4):585-97.
2001: Richard Molenkamp; BC Rozier; Sophie Greve; Willy Spaan; Eric J Snijder
Characterization of an arterivirus defective interfering RNA. Replication and homologous recombination.
Advances in experimental medicine and biology 2001;494():519-25.
2000: Alexander O. Pasternak; Alexander P Gultyaev; Willy Spaan; Eric J Snijder
Genetic manipulation of arterivirus alternative mRNA leader-body junction sites reveals tight regulation of structural protein expression.
Journal of virology 2000;74(24):11642-53.
2000: Richard Molenkamp; Hans Van Tol; BC Rozier; Yvonne van der Meer; Willy Spaan; Eric J Snijder
The arterivirus replicase is the only viral protein required for genome replication and subgenomic mRNA transcription.
The Journal of general virology 2000;81(Pt 10):2491-6.
2000: Richard Molenkamp; Sophie Greve; Willy Spaan; Eric J Snijder
Efficient homologous RNA recombination and requirement for an open reading frame during replication of equine arteritis virus defective interfering RNAs.
Journal of virology 2000;74(19):9062-70.
2000: Richard Molenkamp; BC Rozier; Sophie Greve; Willy Spaan; Eric J Snijder
Isolation and characterization of an arterivirus defective interfering RNA genome.
Journal of virology 2000;74(7):3156-65.
1999: G van Marle; Jessika C Dobbe; Alexander P Gultyaev; W Luytjes; Willy Spaan; Eric J Snijder
Arterivirus discontinuous mRNA transcription is guided by base pairing between sense and antisense transcription-regulating sequences.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):12056-61.
1999: Yvonne van der Meer; Eric J Snijder; Jessika C Dobbe; Sibylle Schleich; Mark Denison; Willy Spaan; Jacomine Krijnse Locker
Localization of mouse hepatitis virus nonstructural proteins and RNA synthesis indicates a role for late endosomes in viral replication.
Journal of virology 1999;73(9):7641-57.
1999: Mark Denison; Willy Spaan; Yvonne van der Meer; CA Gibson; Amy C Sims; Erik Prentice; Xiao Tao Lu
The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis.
Journal of virology 1999;73(8):6862-71.
1999: G van Marle; Leonie C van Dinten; Willy Spaan; W Luytjes; Eric J Snijder
Characterization of an equine arteritis virus replicase mutant defective in subgenomic mRNA synthesis.
Journal of virology 1999;73(7):5274-81.
1999: Aloys C M Kroes; D Leendertse; Willy Spaan
Access to treatment for HIV in developing countries.
Lancet 1999;353(9147):153.
1997: Richard Molenkamp; Willy Spaan
Identification of a specific interaction between the coronavirus mouse hepatitis virus A59 nucleocapsid protein and packaging signal.
Virology 1997;239(1):78-86.
1997: EC Bos; W Luytjes; Willy Spaan
The function of the spike protein of mouse hepatitis virus strain A59 can be studied on virus-like particles: cleavage is not required for infectivity.
Journal of virology 1997;71(12):9427-33.
1997: Fred Wassenaar; Willy Spaan; Alexander E Gorbalenya; Eric J Snijder
Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: evidence that NSP2 acts as a cofactor for the NSP4 serine protease.
Journal of virology 1997;71(12):9313-22.
1997: EC Bos; Jessika C Dobbe; W Luytjes; Willy Spaan
A subgenomic mRNA transcript of the coronavirus mouse hepatitis virus strain A59 defective interfering (DI) RNA is packaged when it contains the DI packaging signal.
Journal of virology 1997;71(7):5684-7.
1997: L Zhang; F Homberger; Willy Spaan; W Luytjes
Recombinant genomic RNA of coronavirus MHV-A59 after coreplication with a DI RNA containing the MHV-RI spike gene.
Virology 1997;230(1):93-102.
1997: Leonie C van Dinten; J A den Boon; Fred Wassenaar; Willy Spaan; Eric J Snijder
An infectious arterivirus cDNA clone: identification of a replicase point mutation that abolishes discontinuous mRNA transcription.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(3):991-6.
1997: W Luytjes; H Gerritsma; EC Bos; Willy Spaan
Characterization of two temperature-sensitive mutants of coronavirus mouse hepatitis virus strain A59 with maturation defects in the spike protein.
Journal of virology 1997;71(2):949-55.
1997: Katrien Grunberg; MC Timmers; HH Smits; E P A de Klerk; EC Dick; Willy Spaan; Pieter S Hiemstra; Peter J Sterk
Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1997;27(1):36-45.
1997: Rene Rijnbrand; Tahar van der Straaten; P A van Rijn; Willy Spaan; Peter J Bredenbeek
Internal entry of ribosomes is directed by the 5' noncoding region of classical swine fever virus and is dependent on the presence of an RNA pseudoknot upstream of the initiation codon.
Journal of virology 1997;71(1):451-7.
1996: A M van Elsacker-Neile; Frank P Kroon; Marchina E Van Der Ende; M M Salimans; Willy Spaan; A C Kroes
Prevalence of parvovirus B19 infection in patients infected with human immunodeficiency virus.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1996;23(6):1255-60.
1996: R C Rijnbrand; T E Abbink; P C Haasnoot; Willy Spaan; P J Bredenbeek
The influence of AUG codons in the hepatitis C virus 5' nontranslated region on translation and mapping of the translation initiation window.
Virology 1996;226(1):47-56.
1996: Leonie C van Dinten; Fred Wassenaar; Alexander E Gorbalenya; Willy Spaan; Eric J Snijder
Processing of the equine arteritis virus replicase ORF1b protein: identification of cleavage products containing the putative viral polymerase and helicase domains.
Journal of virology 1996;70(10):6625-33.
1996: A C Kroes; J A Kluytmans; M F Peeters; Willy Spaan
[Acyclovir freely obtainable].
Nederlands tijdschrift voor geneeskunde 1996;140(27):1412-3.
1996: J A den Boon; M F Kleijnen; Willy Spaan; Eric J Snijder
Equine arteritis virus subgenomic mRNA synthesis: analysis of leader-body junctions and replicative-form RNAs.
Journal of virology 1996;70(7):4291-8.
1996: R Franssila; M Söderlund; C S Brown; Willy Spaan; I Seppälä; Klaus Hedman
IgG subclass response to human parvovirus B19 infection.
Clinical and diagnostic virology 1996;6(1):41-9.
1996: E C Bos; W Luytjes; Hans van der Meulen; Henk koerten; Willy Spaan
The production of recombinant infectious DI-particles of a murine coronavirus in the absence of helper virus.
Virology 1996;218(1):52-60.
1996: Eric J Snijder; Fred Wassenaar; Leonie C van Dinten; Willy Spaan; Alexander E Gorbalenya
The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases.
The Journal of biological chemistry 1996;271(9):4864-71.
1996: W Luytjes; H Gerritsma; Willy Spaan
Replication of synthetic defective interfering RNAs derived from coronavirus mouse hepatitis virus-A59.
Virology 1996;216(1):174-83.
1995: E C Bos; L Heijnen; W Luytjes; Willy Spaan
Mutational analysis of the murine coronavirus spike protein: effect on cell-to-cell fusion.
Virology 1995;214(2):453-63.
1995: M Söderlund; C S Brown; Willy Spaan; Lea Hedman; Klaus Hedman
Epitope type-specific IgG responses to capsid proteins VP1 and VP2 of human parvovirus B19.
The Journal of infectious diseases 1995;172(6):1431-6.
1995: G van Marle; W Luytjes; Robbert van der Most; Tahar van der Straaten; Willy Spaan
Regulation of coronavirus mRNA transcription.
Journal of virology 1995;69(12):7851-6.
1995: J A Den Boon; Willy Spaan; Eric J Snijder
Equine arteritis virus subgenomic RNA transcription: UV inactivation and translation inhibition studies.
Virology 1995;213(2):364-72.
1995: David Cheung; EC Dick; MC Timmers; E P A de Klerk; Willy Spaan; Peter J Sterk
Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo.
American journal of respiratory and critical care medicine 1995;152(5 Pt 1):1490-6.
1995: M H Heemskerk; H M Schoemaker; I De Jong; Virgil E J C Schijns; Willy Spaan; Claire J P Boog
Differential activation of mouse hepatitis virus-specific CD4+ cytotoxic T cells is defined by peptide length.
Immunology 1995;85(4):517-22.
1995: Eric J Snijder; Fred Wassenaar; Willy Spaan; Alexander E Gorbalenya
The arterivirus Nsp2 protease. An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases.
The Journal of biological chemistry 1995;270(28):16671-6.
1995: Robbert van der Most; W Luytjes; S Rutjes; Willy Spaan
Translation but not the encoded sequence is essential for the efficient propagation of the defective interfering RNAs of the coronavirus mouse hepatitis virus.
Journal of virology 1995;69(6):3744-51.
1995: R Rijnbrand; P Bredenbeek; Tahar van der Straaten; L Whetter; G Inchauspé; S Lemon; Willy Spaan
Almost the entire 5' non-translated region of hepatitis C virus is required for cap-independent translation.
FEBS letters 1995;365(2-3):115-9.
1995: M H Heemskerk; H M Schoemaker; Willy Spaan; Claire J P Boog
Predominance of MHC class II-restricted CD4+ cytotoxic T cells against mouse hepatitis virus A59.
Immunology 1995;84(4):521-7.
1995: M H Heemskerk; Marco W Schilham; H M Schoemaker; G Spierenburg; Willy Spaan; Claire J P Boog
Activation of virus-specific major histocompatibility complex class II-restricted CD8+ cytotoxic T cells in CD4-deficient mice.
European journal of immunology 1995;25(4):1109-12.
1995: G van Marle; Robbert van der Most; Tahar van der Straaten; W Luytjes; Willy Spaan
Regulation of transcription of coronaviruses.
Advances in experimental medicine and biology 1995;380():507-10.
1995: Eric J Snijder; Fred Wassenaar; J A Den Boon; Willy Spaan
Proteolytic processing of the arterivirus replicase.
Advances in experimental medicine and biology 1995;380():443-51.
1995: E C Bos; L Heijnen; Willy Spaan
Site directed mutagenesis of the murine coronavirus spike protein. Effects on fusion.
Advances in experimental medicine and biology 1995;380():283-6.
1994: Eric J Snijder; Fred Wassenaar; Willy Spaan
Proteolytic processing of the replicase ORF1a protein of equine arteritis virus.
Journal of virology 1994;68(9):5755-64.
1994: W M van Grunsven; Willy Spaan; Jaap Middeldorp
Localization and diagnostic application of immunodominant domains of the BFRF3-encoded Epstein-Barr virus capsid protein.
The Journal of infectious diseases 1994;170(1):13-9.
1994: Robbert van der Most; R J de Groot; Willy Spaan
Subgenomic RNA synthesis directed by a synthetic defective interfering RNA of mouse hepatitis virus: a study of coronavirus transcription initiation.
Journal of virology 1994;68(6):3656-66.
1994: C S Brown; Sytske Welling-Wester; M Feijlbrief; J W M van Lent; Willy Spaan
Chimeric parvovirus B19 capsids for the presentation of foreign epitopes.
Virology 1994;198(2):477-88.
1994: R de Groot; L Heijnen; Robbert van der Most; Willy Spaan
Homologous RNA recombination allows efficient introduction of site-specific mutations into the genome of coronavirus MHV-A59 via synthetic co-replicating RNAs.
Archives of virology. Supplementum 1994;9():221-30.
1993: W M van Grunsven; E C van Heerde; H J de Haard; Willy Spaan; Jaap Middeldorp
Gene mapping and expression of two immunodominant Epstein-Barr virus capsid proteins.
Journal of virology 1993;67(7):3908-16.
1993: C Daniel; R Anderson; M J Buchmeier; J O Fleming; Willy Spaan; H Wege; Pierre J Talbot
Identification of an immunodominant linear neutralization domain on the S2 portion of the murine coronavirus spike glycoprotein and evidence that it forms part of complex tridimensional structure.
Journal of virology 1993;67(3):1185-94.
1993: Eric J Snijder; Marian C Horzinek; Willy Spaan
The coronaviruslike superfamily.
Advances in experimental medicine and biology 1993;342():235-44.
1993: Eric J Snijder; Fred Wassenaar; Willy Spaan
Proteolytic processing of the N-terminal region of the equine arteritis virus replicase.
Advances in experimental medicine and biology 1993;342():227-32.
1993: Harry Vennema; L Heijnen; Peter J M Rottier; Marian C Horzinek; Willy Spaan
A novel glycoprotein of feline infectious peritonitis coronavirus contains a KDEL-like endoplasmic reticulum retention signal.
Advances in experimental medicine and biology 1993;342():209-14.
1993: Robbert van der Most; L Heijnen; Willy Spaan; R de Groot
Homologous RNA recombination allows efficient introduction of site-specific mutations into the genome of coronavirus MHV-A59 via synthetic co-replicating RNAs.
Advances in experimental medicine and biology 1993;342():149-54.
1993: M H Heemskerk; H M Schoemaker; H E Alphen; Ruurd van der Zee; I Joosten; Willy Spaan; Claire J P Boog
Determination of the cytotoxic T cell epitopes of mouse hepatitis virus, using elution of viral peptides from class I MHC molecules as an approach.
Advances in experimental medicine and biology 1993;342():407-12.
1992: C S Brown; T Jensen; R H Meloen; W Puijk; K Sugamura; H Sato; Willy Spaan
Localization of an immunodominant domain on baculovirus-produced parvovirus B19 capsids: correlation to a major surface region on the native virus particle.
Journal of virology 1992;66(12):6989-96.
1992: Eric J Snijder; Fred Wassenaar; Willy Spaan
The 5' end of the equine arteritis virus replicase gene encodes a papainlike cysteine protease.
Journal of virology 1992;66(12):7040-8.
1992: R J de Groot; Robbert van der Most; Willy Spaan
The fitness of defective interfering murine coronavirus DI-a and its derivatives is decreased by nonsense and frameshift mutations.
Journal of virology 1992;66(10):5898-905.
1992: M M Salimans; M J van Bussel; C S Brown; Willy Spaan
Recombinant parvovirus B19 capsids as a new substrate for detection of B19-specific IgG and IgM antibodies by an enzyme-linked immunosorbent assay.
Journal of virological methods 1992;39(3):247-58.
1992: Harry Vennema; L Heijnen; Peter J M Rottier; Marian C Horzinek; Willy Spaan
A novel glycoprotein of feline infectious peritonitis coronavirus contains a KDEL-like endoplasmic reticulum retention signal.
Journal of virology 1992;66(8):4951-6.
1992: Robbert van der Most; L Heijnen; Willy Spaan; R J de Groot
Homologous RNA recombination allows efficient introduction of site-specific mutations into the genome of coronavirus MHV-A59 via synthetic co-replicating RNAs.
Nucleic acids research 1992;20(13):3375-81.
1991: Harry Vennema; R Rijnbrand; L Heijnen; Marian C Horzinek; Willy Spaan
Enhancement of the vaccinia virus/phage T7 RNA polymerase expression system using encephalomyocarditis virus 5'-untranslated region sequences.
Gene 1991;108(2):201-9.
1991: Eric J Snijder; J A den Boon; Marian C Horzinek; Willy Spaan
Characterization of defective interfering RNAs of Berne virus.
The Journal of general virology 1991;72 ( Pt 7)():1635-43.
1991: Robbert van der Most; P J Bredenbeek; Willy Spaan
A domain at the 3' end of the polymerase gene is essential for encapsidation of coronavirus defective interfering RNAs.
Journal of virology 1991;65(6):3219-26.
1991: E J Hogervorst; L Schouls; Josée P A Wagenaar; Claire J P Boog; Willy Spaan; Jan D A Van Embden; Willem van Eden
Modulation of experimental autoimmunity: treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus.
Infection and immunity 1991;59(6):2029-35.
1991: J A den Boon; Eric J Snijder; E D Chirnside; Antoine A F de Vries; Marian C Horzinek; Willy Spaan
Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily.
Journal of virology 1991;65(6):2910-20.
1991: C S Brown; J W M van Lent; Just M Vlak; Willy Spaan
Assembly of empty capsids by using baculovirus recombinants expressing human parvovirus B19 structural proteins.
Journal of virology 1991;65(5):2702-6.
1991: Harry Vennema; Raoul J de Groot; D A Harbour; Marian C Horzinek; Willy Spaan
Primary structure of the membrane and nucleocapsid protein genes of feline infectious peritonitis virus and immunogenicity of recombinant vaccinia viruses in kittens.
Virology 1991;181(1):327-35.
1991: Eric J Snijder; J A den Boon; Marian C Horzinek; Willy Spaan
Comparison of the genome organization of toro- and coronaviruses: evidence for two nonhomologous RNA recombination events during Berne virus evolution.
Virology 1991;180(1):448-52.
1990: M J Koolen; M A Borst; Marian C Horzinek; Willy Spaan
Immunogenic peptide comprising a mouse hepatitis virus A59 B-cell epitope and an influenza virus T-cell epitope protects against lethal infection.
Journal of virology 1990;64(12):6270-3.
1990: E D Chirnside; Willy Spaan
Reverse transcription and cDNA amplification by the polymerase chain reaction of equine arteritis virus (EAV).
Journal of virological methods 1990;30(2):133-40.
1990: Eric J Snijder; J A Den Boon; Willy Spaan; M Weiss; Marian C Horzinek
Primary structure and post-translational processing of the Berne virus peplomer protein.
Virology 1990;178(2):355-63.
1990: Eric J Snijder; J A den Boon; P J Bredenbeek; Marian C Horzinek; R Rijnbrand; Willy Spaan
The carboxyl-terminal part of the putative Berne virus polymerase is expressed by ribosomal frameshifting and contains sequence motifs which indicate that toro- and coronaviruses are evolutionarily related.
Nucleic acids research 1990;18(15):4535-42.
1990: Antoine A F de Vries; E D Chirnside; P J Bredenbeek; L A Gravestein; Marian C Horzinek; Willy Spaan
All subgenomic mRNAs of equine arteritis virus contain a common leader sequence.
Nucleic acids research 1990;18(11):3241-7.
1990: D Cavanagh; D A Brian; L Enjuanes; K V Holmes; M M Lai; H Laude; S G Siddell; Willy Spaan; F Taguchi; P J Talbot
Recommendations of the Coronavirus Study Group for the nomenclature of the structural proteins, mRNAs, and genes of coronaviruses.
Virology 1990;176(1):306-7.
1990: P J Bredenbeek; Catherine J Pachuk; A F Noten; J Charité; W Luytjes; Susan R Weiss; Willy Spaan
The primary structure and expression of the second open reading frame of the polymerase gene of the coronavirus MHV-A59; a highly conserved polymerase is expressed by an efficient ribosomal frameshifting mechanism.
Nucleic acids research 1990;18(7):1825-32.
1990: P J Bredenbeek; A F Noten; Marian C Horzinek; Willy Spaan
Identification and stability of a 30-kDa nonstructural protein encoded by mRNA 2 of mouse hepatitis virus in infected cells.
Virology 1990;175(1):303-6.
1990: Harry Vennema; Raoul J de Groot; D A Harbour; M Dalderup; T Gruffydd-Jones; Marian C Horzinek; Willy Spaan
Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization.
Journal of virology 1990;64(3):1407-9.
1990: Harry Vennema; L Heijnen; A Zijderveld; Marian C Horzinek; Willy Spaan
Intracellular transport of recombinant coronavirus spike proteins: implications for virus assembly.
Journal of virology 1990;64(1):339-46.
1990: Eric J Snijder; Marian C Horzinek; Willy Spaan
A 3'-coterminal nested set of independently transcribed mRNAs is generated during Berne virus replication.
Journal of virology 1990;64(1):331-8.
1990: Harry Vennema; Peter J M Rottier; L Heijnen; G J Godeke; Marian C Horzinek; Willy Spaan
Biosynthesis and function of the coronavirus spike protein.
Advances in experimental medicine and biology 1990;276():9-19.
1990: D Cavanagh; D Brian; L Enjuanes; K Holmes; M Lai; H Laude; S Siddell; Willy Spaan; F Taguchi; P Talbot
Revised nomenclature for coronavirus structural proteins, mRNAs and genes.
Advances in experimental medicine and biology 1990;276():1-2.
1990: M Daya; F Wong; M Cervin; G Evans; H Vennema; Willy Spaan; R Anderson
Mouse fibroblast mutants selected for survival against mouse hepatitis virus infection show increased resistance to infection and virus-induced cell fusion.
Advances in experimental medicine and biology 1990;276():59-66.
1990: P J Bredenbeek; Eric J Snijder; F H Noten; J A den Boon; Wim M M Schaaper; Marian C Horzinek; Willy Spaan
The polymerase gene of corona- and toroviruses: evidence for an evolutionary relationship.
Advances in experimental medicine and biology 1990;276():307-16.
1990: Harry Vennema; Raoul J de Groot; D A Harbour; M Dalderup; T Gruffydd-Jones; Marian C Horzinek; Willy Spaan
Immunogenicity of recombinant feline infectious peritonitis virus spike protein in mice and kittens.
Advances in experimental medicine and biology 1990;276():217-22.
1990: Willy Spaan
Background paper. Progress towards a coronavirus recombinant DNA vaccine.
Advances in experimental medicine and biology 1990;276():201-3.
1990: Peter J M Rottier; Jacomine Krijnse Locker; Marian C Horzinek; Willy Spaan
Expression of MHV-A59 M glycoprotein: effects of deletions on membrane integration and intracellular transport.
Advances in experimental medicine and biology 1990;276():127-35.
1990: W P Posthumus; Rob H Meloen; Luis Enjuanes; I Correa; A P van Nieuwstadt; G Koch; Raoul J de Groot; J G Kusters; W Luytjes; Willy Spaan
Linear neutralizing epitopes on the peplomer protein of coronaviruses.
Advances in experimental medicine and biology 1990;276():181-8.
1989: Eric J Snijder; J A den Boon; Willy Spaan; Georges M G M Verjans; Marian C Horzinek
Identification and primary structure of the gene encoding the Berne virus nucleocapsid protein.
The Journal of general virology 1989;70 ( Pt 12)():3363-70.
1989: M Daya; F Wong; M Cervin; G Evans; H Vennema; Willy Spaan; R Anderson
Mutation of host cell determinants which discriminate between lytic and persistent mouse hepatitis virus infection results in a fusion-resistant phenotype.
The Journal of general virology 1989;70 ( Pt 12)():3335-46.
1989: Raoul J de Groot; R W Van Leen; M J Dalderup; Harry Vennema; Marian C Horzinek; Willy Spaan
Stably expressed FIPV peplomer protein induces cell fusion and elicits neutralizing antibodies in mice.
Virology 1989;171(2):493-502.
1989: Catherine J Pachuk; P J Bredenbeek; P W Zoltick; Willy Spaan; Susan R Weiss
Molecular cloning of the gene encoding the putative polymerase of mouse hepatitis coronavirus, strain A59.
Virology 1989;171(1):141-8.
1989: W Luytjes; Dirk Geerts; W Posthumus; Rob H Meloen; Willy Spaan
Amino acid sequence of a conserved neutralizing epitope of murine coronaviruses.
Journal of virology 1989;63(3):1408-12.
1988: Raoul J de Groot; A C Andeweg; Marian C Horzinek; Willy Spaan
Sequence analysis of the 3'-end of the feline coronavirus FIPV 79-1146 genome: comparison with the genome of porcine coronavirus TGEV reveals large insertions.
Virology 1988;167(2):370-6.
1988: Reinhard Vlasak; W Luytjes; Jason Leider; Willy Spaan; Peter Palese
The E3 protein of bovine coronavirus is a receptor-destroying enzyme with acetylesterase activity.
Journal of virology 1988;62(12):4686-90.
1988: Willy Spaan; D Cavanagh; Marian C Horzinek
Coronaviruses: structure and genome expression.
The Journal of general virology 1988;69 ( Pt 12)():2939-52.
1988: D A Konings; P J Bredenbeek; J F Noten; Paulien Hogeweg; Willy Spaan
Differential premature termination of transcription as a proposed mechanism for the regulation of coronavirus gene expression.
Nucleic acids research 1988;16(22):10849-60.
1988: W Luytjes; P J Bredenbeek; A F Noten; Marian C Horzinek; Willy Spaan
Sequence of mouse hepatitis virus A59 mRNA 2: indications for RNA recombination between coronaviruses and influenza C virus.
Virology 1988;166(2):415-22.
1988: Eric J Snijder; J Ederveen; Willy Spaan; M Weiss; Marian C Horzinek
Characterization of Berne virus genomic and messenger RNAs.
The Journal of general virology 1988;69 ( Pt 9)():2135-44.
1988: Reinhard Vlasak; W Luytjes; Willy Spaan; Peter Palese
Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(12):4526-9.
1987: W Luytjes; L S Sturman; P J Bredenbeek; J Charite; Bernard A.M. Van der Zeijst; Marian C Horzinek; Willy Spaan
Primary structure of the glycoprotein E2 of coronavirus MHV-A59 and identification of the trypsin cleavage site.
Virology 1987;161(2):479-87.
1987: L Jacobs; R de Groot; Bernard A.M. Van der Zeijst; Marian C Horzinek; Willy Spaan
The nucleotide sequence of the peplomer gene of porcine transmissible gastroenteritis virus (TGEV): comparison with the sequence of the peplomer protein of feline infectious peritonitis virus (FIPV).
Virus research 1987;8(4):363-71.
1987: Raoul J de Groot; J Maduro; Johannes A Lenstra; Marian C Horzinek; Bernard A.M. Van der Zeijst; Willy Spaan
cDNA cloning and sequence analysis of the gene encoding the peplomer protein of feline infectious peritonitis virus.
The Journal of general virology 1987;68 ( Pt 10)():2639-46.
1987: Raoul J de Groot; W Luytjes; Marian C Horzinek; Bernard A.M. Van der Zeijst; Willy Spaan; Johannes A Lenstra
Evidence for a coiled-coil structure in the spike proteins of coronaviruses.
Journal of molecular biology 1987;196(4):963-6.
1987: M C Horzinek; T H Flewett; L J Saif; Willy Spaan; M Weiss; G N Woode
A new family of vertebrate viruses: Toroviridae.
Intervirology 1987;27(1):17-24.
1987: P J Bredenbeek; J Charite; J F Noten; W Luytjes; Marian C Horzinek; Bernard A.M. Van der Zeijst; Willy Spaan
Sequences involved in the replication of coronaviruses.
Advances in experimental medicine and biology 1987;218():65-72.
1987: Raoul J de Groot; Johannes A Lenstra; W Luytjes; H G Niesters; Marian C Horzinek; Bernard A.M. Van der Zeijst; Willy Spaan
Sequence and structure of the coronavirus peplomer protein.
Advances in experimental medicine and biology 1987;218():31-8.
1987: H G Niesters; J G Kusters; Johannes A Lenstra; Willy Spaan; M C Horzined; Bernard A.M. Van der Zeijst
The neutralization epitopes on the spike protein of infectious bronchitis virus and their antigenic variation.
Advances in experimental medicine and biology 1987;218():483-92.
1986: P J Bredenbeek; J F Noten; J A Lenstra; Marian C Horzinek; Bernard A.M. Van der Zeijst; Willy Spaan
The nucleotide sequence of the extreme 5' end of the avian coronavirus genome; implications for the discontinuous mRNA synthesis.
Nucleic acids research 1986;14(19):7806.
1986: H G Niesters; J A Lenstra; Willy Spaan; A J Zijderveld; Nancy M C Bleumink-Pluym; F Hong; G J van Scharrenburg; Marian C Horzinek; Bernard A.M. Van der Zeijst
The peplomer protein sequence of the M41 strain of coronavirus IBV and its comparison with Beaudette strains.
Virus research 1986;5(2-3):253-63.
1986: M F van Berlo; P J Rottier; Willy Spaan; M C Horzinek
Equine arteritis virus-induced polypeptide synthesis.
The Journal of general virology 1986;67 ( Pt 8)():1543-9.
1984: Willy Spaan; H Delius; M A Skinner; J Armstrong; P Rottier; S Smeekens; S G Siddell; B van der Zeijst
Transcription strategy of coronaviruses: fusion of non-contiguous sequences during mRNA synthesis.
Advances in experimental medicine and biology 1984;173():173-86.
1984: J Armstrong; S Smeekens; Willy Spaan; P Rottier; B van der Zeijst
Cloning and sequencing the nucleocapsid and E1 genes of coronavirus.
Advances in experimental medicine and biology 1984;173():155-62.
1983: Willy Spaan; H Delius; M Skinner; J Armstrong; P Rottier; S Smeekens; Bernard A.M. Van der Zeijst; S G Siddell
Coronavirus mRNA synthesis involves fusion of non-contiguous sequences.
The EMBO journal 1983;2(10):1839-44.
1982: Willy Spaan; P J Rottier; M C Horzinek; Bernard A.M. Van der Zeijst
Sequence relationships between the genome and the intracellular RNA species 1, 3, 6, and 7 of mouse hepatitis virus strain A59.
Journal of virology 1982;42(2):432-9.
1981: L Jacobs; Willy Spaan; M C Horzinek; Bernard A.M. Van der Zeijst
Synthesis of subgenomic mRNA's of mouse hepatitis virus is initiated independently: evidence from UV transcription mapping.
Journal of virology 1981;39(2):401-6.
1981: P J Rottier; Willy Spaan; M C Horzinek; Bernard A.M. Van der Zeijst
Translation of three mouse hepatitis virus strain A59 subgenomic RNAs in Xenopus laevis oocytes.
Journal of virology 1981;38(1):20-6.
1981: Willy Spaan; P J Rottier; M C Horzinek; Bernard A.M. Van der Zeijst
Isolation and identification of virus-specific mRNAs in cells infected with mouse hepatitis virus (MHV-A59).
Virology 1981;108(2):424-34.
1981: Bernard A.M. Van der Zeijst; M C Horzinek; L Jacobs; P J Rottier; Willy Spaan
Messenger RNAs of mouse hepatitis virus A59: isolation and characterization, translation in Xenopus laevis oocytes of RNAs 3, 6 and 7, UV target sizes of the transcription templates.
Advances in experimental medicine and biology 1981;142():209-25.
1980: A Thomas; Willy Spaan; Harry van Steeg; Harry O Voorma; Rob Benne
Mode of action of protein synthesis initiation factor eIF-1 from rabbit reticulocytes.
FEBS letters 1980;116(1):67-71.