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Markku Seppala

Research Profile

Chemicals & Drugs

Physiology

Pregnancy

Procedures

Anatomy

Disorders

Uterine Neoplasms

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Publications

TOP 3
K K W Lam; C-L Lee; R T K Pang; Markku Seppala; W S B Yeung; P-C Ho; H Koistinen; Philip Chiu
Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line.
Kevin K W Lam; Cheuk Lun Lee; Carmen O N Leung; Pang Ronald; Markku Seppala; Philip Chiu; Pak-Chung Ho; Hannu Koistinen; William S B Yeung
Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway.
Cheuk Lun Lee; Pang Ronald; Markku Seppala; William S B Yeung; Nelson Fernandez; Hannu Koistinen; Maciej Kurpisz; Kevin Lam; Philip Chiu
Glycodelin-A as a paracrine regulator in early pregnancy.

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All Publications

2012: K K W Lam; C-L Lee; R T K Pang; Markku Seppala; W S B Yeung; P-C Ho; H Koistinen; Philip Chiu
Glycodelin-A modulates syncytialization of human BeWo choriocarcinoma cell line.
Placenta 2012;33(9):750-2.
2011: Kevin K W Lam; Cheuk Lun Lee; Carmen O N Leung; Pang Ronald; Markku Seppala; Philip Chiu; Pak-Chung Ho; Hannu Koistinen; William S B Yeung
Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway.
The Journal of biological chemistry 2011;286(43):37118-27.
2011: Cheuk Lun Lee; Pang Ronald; Markku Seppala; William S B Yeung; Nelson Fernandez; Hannu Koistinen; Maciej Kurpisz; Kevin Lam; Philip Chiu
Glycodelin-A as a paracrine regulator in early pregnancy.
Journal of reproductive immunology 2011;90(1):29-34.
2011: Cheuk Lun Lee; Philip C N Chiu; Kevin Lam; Siu-On Siu; Ivan Chu; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Kai-Fai Lee; Philip Chiu
Differential actions of glycodelin-A on Th-1 and Th-2 cells: a paracrine mechanism that could produce the Th-2 dominant environment during pregnancy.
Human reproduction (Oxford, England) 2011;26(3):517-26.
2010: Marta Durand; Riitta Koistinen; Mayel Chirinos; José Luis Rodríguez; Elena Zambrano; Markku Seppala; Fernando Larrea
Hormonal evaluation and midcycle detection of intrauterine glycodelin in women treated with levonorgestrel as in emergency contraception.
Contraception 2010;82(6):526-33.
2010: Philip C N Chiu; Ben S T Wong; Cheuk Lun Lee; Kevin Lam; Man-Kin Chung; Kai-Fai Lee; Riitta Koistinen; Hannu Koistinen; Satish K Gupta; Markku Seppala; Philip Chiu
Zona pellucida-induced acrosome reaction in human spermatozoa is potentiated by glycodelin-A via down-regulation of extracellular signal-regulated kinases and up-regulation of zona pellucida-induced calcium influx.
Human reproduction (Oxford, England) 2010;25(11):2721-33.
2010: Cheuk Lun Lee; Philip C N Chiu; Kevin Lam; Rachel W S Chan; Ivan K Chu; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Kai-Fai Lee; Philip Chiu
Glycodelin-A modulates cytokine production of peripheral blood natural killer cells.
Fertility and sterility 2010;94(2):769-71.
2009: William S B Yeung; Kai-Fai Lee; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Philip Chiu
Effects of glycodelins on functional competence of spermatozoa.
Journal of reproductive immunology 2009;83(1-2):26-30.
2009: Man-Kin Chung; Philip Chiu; Cheuk Lun Lee; Pang Ronald; Ernest Hung Yu Ng; Kai-Fai Lee; Riitta Koistinen; Hannu Koistinen; Markku Seppala; William S B Yeung
Cumulus-associated alpha2-macroglobulin derivative retains proconceptive glycodelin-C in the human cumulus matrix.
Human reproduction (Oxford, England) 2009;24(11):2856-67.
2009: Kevin Lam; Philip Chiu; Man-Kin Chung; Cheuk Lun Lee; Kai-Fai Lee; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Pak Chung Ho; William S B Yeung
Glycodelin-A as a modulator of trophoblast invasion.
Human reproduction (Oxford, England) 2009;24(9):2093-103.
2009: Cheuk Lun Lee; Poh-Choo Pang; William S B Yeung; Bérangère Tissot; Maria Panico; Terence T H Lao; Ivan Chu; Kai-Fai Lee; Man-Kin Chung; Kevin Lam; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Howard R Morris; Anne Dell; Philip Chiu
Effects of differential glycosylation of glycodelins on lymphocyte survival.
The Journal of biological chemistry 2009;284(22):15084-96.
2009: Markku Seppala; Hannu Koistinen; Riitta Koistinen; L Hautala; Philip Chiu; William S B Yeung
Glycodelin in reproductive endocrinology and hormone-related cancer.
European journal of endocrinology / European Federation of Endocrine Societies 2009;160(2):121-33.
2008: Laura C Hautala; Riitta Koistinen; Markku Seppala; Ralf Bützow; Ulf-Hakan Stenman; Pirjo Laakkonen; Hannu Koistinen
Glycodelin reduces breast cancer xenograft growth in vivo.
International journal of cancer. Journal international du cancer 2008;123(10):2279-84.
2007: Josiane A A do Nascimento; Markku Seppala; Antero Perdigão; Ximena Espejo-Arce; María José Munuce; Laura Hautala; Riitta Koistinen; Liliana Andrade; Luis Bahamondes
In vivo assessment of the human sperm acrosome reaction and the expression of glycodelin-A in human endometrium after levonorgestrel-emergency contraceptive pill administration.
Human reproduction (Oxford, England) 2007;22(8):2190-5.
2007: Markku Seppala; Hannu Koistinen; Riitta Koistinen; Philip Chiu; William S B Yeung
Glycosylation related actions of glycodelin: gamete, cumulus cell, immune cell and clinical associations.
Human reproduction update 2007;13(3):275-87.
2007: Philip Chiu; Man-Kin Chung; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Pak Chung Ho; Ernest Hung Yu Ng; Kai-Fai Lee; William S B Yeung
Cumulus oophorus-associated glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding.
The Journal of biological chemistry 2007;282(8):5378-88.
2007: Markku Seppala; Hannu Koistinen; Riitta Koistinen; Philip Chiu; William S B Yeung
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2007;123(14):1670-2.
2007: William S B Yeung; Kai-Fai Lee; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Pak Chung Ho; Philip Chiu
Glycodelin: a molecule with multi-functions on spermatozoa.
Society of Reproduction and Fertility supplement 2007;63():143-51.
2007: Philip Chiu; Man-Kin Chung; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Pak Chung Ho; Ernest Hung Yu Ng; Kai-Fai Lee; William S B Yeung
Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding.
Journal of cell science 2007;120(Pt 1):33-44.
2006: Hannu Koistinen; Markku Seppala; Sakari Knuutila; Riitta Koistinen
Extracellular matrix-induced changes in expression of cell cycle-related proteins and proteasome components in endometrial adenocarcinoma cells.
Gynecologic oncology 2006;102(3):546-51.
2006: Anneli Stavreus-Evers; Erik Mandelin; Riitta Koistinen; Lusine Aghajanova; Lusine Aghajnova; Outi Hovatta; Markku Seppala
Glycodelin is present in pinopodes of receptive-phase human endometrium and is associated with down-regulation of progesterone receptor B.
Fertility and sterility 2006;85(6):1803-11.
2006: William S B Yeung; Kai-Fai Lee; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Pak Chung Ho; Philip Chiu
Roles of glycodelin in modulating sperm function.
Molecular and cellular endocrinology 2006;250(1-2):149-56.
2006: Markku Seppala; Hannu Koistinen; Riitta Koistinen; Philip Chiu; William S B Yeung
[Not Available].
Duodecim; lääketieteellinen aikakauskirja 2006;122(12):1439-44.
2005: Hannu Koistinen; Markku Seppala; Balint Nagy; Johanna Tapper; Sakari Knuutila; Riitta Koistinen
Glycodelin reduces carcinoma-associated gene expression in endometrial adenocarcinoma cells.
American journal of obstetrics and gynecology 2005;193(6):1955-60.
2005: Philip Chiu; Man-Kin Chung; Heng-Yan Tsang; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Kai-Fai Lee; William S B Yeung
Glycodelin-S in human seminal plasma reduces cholesterol efflux and inhibits capacitation of spermatozoa.
The Journal of biological chemistry 2005;280(27):25580-9.
2005: Marta Durand; Markku Seppala; Ma Del Carmen Cravioto; Hannu Koistinen; Riitta Koistinen; José González-Macedo; Fernando Larrea
Late follicular phase administration of levonorgestrel as an emergency contraceptive changes the secretory pattern of glycodelin in serum and endometrium during the luteal phase of the menstrual cycle.
Contraception 2005;71(6):451-7.
2005: Markku Seppala; Erik Mandelin; Riitta Koistinen; Robert Bergholm; Mirja Tiikkainen; Hannele Yki-Järvinen
Glycodelin responses to hyperinsulinaemic clamp vary according to basal serum glycodelin concentration.
Clinical endocrinology 2005;62(5):611-5.
2005: Tarja Kalme; Markku Seppala; Qing Qiao; Riitta Koistinen; Aulikki Nissinen; Maija Harrela; Mikko Loukovaara; Pekka Leinonen; Jaakko Tuomilehto
Sex hormone-binding globulin and insulin-like growth factor-binding protein-1 as indicators of metabolic syndrome, cardiovascular risk, and mortality in elderly men.
The Journal of clinical endocrinology and metabolism 2005;90(3):1550-6.
2004: Markku Seppala
FIGO's Constitution and Bye-Laws.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2004;86(2):190-201.
2004: Philip Chiu; H Y Tsang; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Kai-Fai Lee; William S B Yeung
The contribution of D-mannose, L-fucose, N-acetylglucosamine, and selectin residues on the binding of glycodelin isoforms to human spermatozoa.
Biology of reproduction 2004;70(6):1710-9.
2004: Markku Seppala
Advances in uterine protein research: reproduction and cancer.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2004;85(2):105-18.
2004: Daniela J Jakubowicz; Paulina A Essah; Markku Seppala; Salomon Jakubowicz; Jean-Patrice Baillargeon; Riitta Koistinen; John E Nestler
Reduced serum glycodelin and insulin-like growth factor-binding protein-1 in women with polycystic ovary syndrome during first trimester of pregnancy.
The Journal of clinical endocrinology and metabolism 2004;89(2):833-9.
2003: Hannu Koistinen; Richard L Easton; Philip Chiu; Sara Chalabi; Mervi Halttunen; Anne Dell; Howard R Morris; William S B Yeung; Markku Seppala; Riitta Koistinen
Differences in glycosylation and sperm-egg binding inhibition of pregnancy-related glycodelin.
Biology of reproduction 2003;69(5):1545-51.
2003: Erik Mandelin; Heini Lassus; Markku Seppala; Arto Leminen; Jan-�ke GUSTAFSSON; Guojun Cheng; Ralf Bützow; Riitta Koistinen
Glycodelin in ovarian serous carcinoma: association with differentiation and survival.
Cancer research 2003;63(19):6258-64.
2003: Philip Chiu; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Kai-Fai Lee; William S B Yeung
Zona-binding inhibitory factor-1 from human follicular fluid is an isoform of glycodelin.
Biology of reproduction 2003;69(1):365-72.
2003: Philip Chiu; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Kai-Fai Lee; William S B Yeung
Binding of zona binding inhibitory factor-1 (ZIF-1) from human follicular fluid on spermatozoa.
The Journal of biological chemistry 2003;278(15):13570-7.
2003: Eero Kajantie; Caroline H D Fall; Markku Seppala; Riitta Koistinen; Leo Dunkel; Hilkka Ylihärsilä; Clive Osmond; Sture Andersson; David J P Barker; Tom Forsén; Richard Holt; David I W Phillips; Johan Eriksson
Serum insulin-like growth factor (IGF)-I and IGF-binding protein-1 in elderly people: relationships with cardiovascular risk factors, body composition, size at birth, and childhood growth.
The Journal of clinical endocrinology and metabolism 2003;88(3):1059-65.
2002: Mikko Loukovaara; Riitta Koistinen; Tarja Kalme; Tapio Kurki; Pekka Leinonen; Markku Seppala
Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 in premature rupture of membranes.
Acta obstetricia et gynecologica Scandinavica 2002;81(10):905-8.
2002: Markku Seppala; Robert N Taylor; Hannu Koistinen; Riitta Koistinen; Edwin Milgrom
Glycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation.
Endocrine reviews 2002;23(4):401-30.
2002: Eero Kajantie; Leo Dunkel; Eeva-Marja Rutanen; Markku Seppala; Riitta Koistinen; Annikki Sarnesto; Sture Andersson
IGF-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1, and postnatal growth in very low birth weight infants.
The Journal of clinical endocrinology and metabolism 2002;87(5):2171-9.
2002: Maija Harrela; Qing Qiao; Riitta Koistinen; Jaakko Tuomilehto; Aulikki Nissinen; Markku Seppala; Pekka Leinonen
High serum insulin-like growth factor binding protein-1 is associated with increased cardiovascular mortality in elderly men.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(3):144-9.
2002: Hannu Koistinen; Tuuli Soini; Jari Leinonen; Christel Hyden-Granskog; Jarmo Salo; Mervi Halttunen; Ulf-Hakan Stenman; Markku Seppala; Riitta Koistinen
Monoclonal antibodies, immunofluorometric assay, and detection of human semenogelin in male reproductive tract: no association with in vitro fertilizing capacity of sperm.
Biology of reproduction 2002;66(3):624-8.
2002: J Y M Tse; Philip Chiu; Kai-Fai Lee; Markku Seppala; Hannu Koistinen; Riitta Koistinen; Yuan-Qing Yao; William S B Yeung
The synthesis and fate of glycodelin in human ovary during folliculogenesis.
Molecular human reproduction 2002;8(2):142-8.
2002: Hannu Koistinen; Annukka Paju; Riitta Koistinen; Patrik Finne; Janita Lövgren; Ping Wu; Markku Seppala; Ulf-Hakan Stenman
Prostate-specific antigen and other prostate-derived proteases cleave IGFBP-3, but prostate cancer is not associated with proteolytically cleaved circulating IGFBP-3.
The Prostate 2002;50(2):112-8.
2002: Mikko Loukovaara; Riitta Koistinen; Tapio Kurki; Markku Seppala
Maternal serum glycodelin in premature rupture of membranes.
Journal of perinatal medicine 2002;30(6):480-2.
2002: Julia Arnold; Bruce A Lessey; Markku Seppala; David G Kaufman
Effect of normal endometrial stroma on growth and differentiation in Ishikawa endometrial adenocarcinoma cells.
Cancer research 2002;62(1):79-88.
2001: Marko Niemimaa; Seppo Heinonen; Markku Seppala; Maritta Hippeläinen; Hannu Martikainen; Markku Ryynänen
First-trimester screening for Down's syndrome in in vitro fertilization pregnancies.
Fertility and sterility 2001;76(6):1282-3.
2001: Erik Mandelin; Hannu Koistinen; Riitta Koistinen; Johanna Arola; B Affandi; Markku Seppala
Endometrial expression of glycodelin in women with levonorgestrel-releasing subdermal implants.
Fertility and sterility 2001;76(3):474-8.
2001: Mark A Damario; Timothy G Lesnick; Bruce A Lessey; Ania Kowalik; Erik Mandelin; Markku Seppala; Z Rosenwaks
Endometrial markers of uterine receptivity utilizing the donor oocyte model.
Human reproduction (Oxford, England) 2001;16(9):1893-9.
2001: Markku Seppala
Cloning.
Journal of assisted reproduction and genetics 2001;18(8):473.
2001: Tarja Kalme; Mikko Loukovaara; Hannu Koistinen; Riitta Koistinen; Markku Seppala; Pekka Leinonen
Factors regulating insulin-like growth factor binding protein-3 secretion from human hepatoma (HepG2) cells.
The Journal of steroid biochemistry and molecular biology 2001;78(2):131-5.
2001: Johanna Tapper; Eeva Kettunen; Wa'el El-Rifai; Markku Seppala; Leif C Andersson; Sakari Knuutila
Changes in gene expression during progression of ovarian carcinoma.
Cancer genetics and cytogenetics 2001;128(1):1-6.
2001: Jiaguo Gao; James Mazella; Markku Seppala; Linda Tseng
Ligand activated hPR modulates the glycodelin promoter activity through the Sp1 sites in human endometrial adenocarcinoma cells.
Molecular and cellular endocrinology 2001;176(1-2):97-102.
2001: Julia Arnold; David G Kaufman; Markku Seppala; Bruce A Lessey
Endometrial stromal cells regulate epithelial cell growth in vitro: a new co-culture model.
Human reproduction (Oxford, England) 2001;16(5):836-45.
2001: Markku Seppala; Hannu Koistinen; Riitta Koistinen
Glycodelins.
Trends in endocrinology and metabolism: TEM 2001;12(3):111-7.
2001: Eero Kajantie; Timo Hytinantti; Riitta Koistinen; J Risteli; Eeva-Marja Rutanen; Markku Seppala; Sture Andersson
Markers of type I and type III collagen turnover, insulin-like growth factors, and their binding proteins in cord plasma of small premature infants: relationships with fetal growth, gestational age, preeclampsia, and antenatal glucocorticoid treatment.
Pediatric research 2001;49(4):481-9.
2001: Daniela J Jakubowicz; Markku Seppala; Salomon Jakubowicz; O Rodriguez-Armas; A Rivas-Santiago; Hannu Koistinen; Riitta Koistinen; John E Nestler
Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome.
The Journal of clinical endocrinology and metabolism 2001;86(3):1126-33.
2000: Elizabeth G Raymond; Laurie P Lovely; Mario Chen-Mok; Markku Seppala; Robert J Kurman; Bruce A Lessey
Effect of the Yuzpe regimen of emergency contraception on markers of endometrial receptivity.
Human reproduction (Oxford, England) 2000;15(11):2351-5.
2000: Maija Harrela; Riitta Koistinen; Jaakko Tuomilehto; Aulikki Nissinen; Markku Seppala
Low serum insulin-like growth factor-binding protein-1 is associated with an unfavourable cardiovascular risk profile in elderly men.
Annals of medicine 2000;32(6):424-8.
2000: TL Bützow; Mikko Lehtovirta; Rita Siegberg; Outi Hovatta; R Koistinen; Markku Seppala; Dan Apter
The decrease in luteinizing hormone secretion in response to weight reduction is inversely related to the severity of insulin resistance in overweight women.
The Journal of clinical endocrinology and metabolism 2000;85(9):3271-5.
2000: Hannu Koistinen; Riitta Koistinen; Christel Hydén-Granskog; O Magnus; Markku Seppala
Seminal plasma glycodelin and fertilization in vitro.
Journal of andrology 2000;21(5):636-40.
2000: Patrik Finne; Anssi Auvinen; Hannu Koistinen; Wan-Ming Zhang; Liisa Määttänen; Sakari Rannikko; T Tammela; Markku Seppala; Matti Hakama; Ulf-Hakan Stenman
Insulin-like growth factor I is not a useful marker of prostate cancer in men with elevated levels of prostate-specific antigen.
The Journal of clinical endocrinology and metabolism 2000;85(8):2744-7.
2000: SE Brown; E Mandelin; Sergio Oehninger; James Toner; Markku Seppala; HOWARD JONES
Histochemical localization of endometrial insulin-like growth factor binding protein-1 and -3 during the luteal phase in controlled ovarian hyperstimulation cycles: a controlled study.
Fertility and sterility 2000;74(2):338-42.
2000: IM Van den Nieuwenhof; Hannu Koistinen; Richard L Easton; Riitta Koistinen; Meerit Kämäräinen; Howard R Morris; Irma Van Die; Markku Seppala; Anne Dell; DH van den Eijnden
Recombinant glycodelin carrying the same type of glycan structures as contraceptive glycodelin-A can be produced in human kidney 293 cells but not in chinese hamster ovary cells.
European journal of biochemistry / FEBS 2000;267(15):4753-62.
2000: SE Brown; E Mandelin; Sergio Oehninger; James Toner; Markku Seppala; HOWARD JONES
Endometrial glycodelin-A expression in the luteal phase of stimulated ovarian cycles.
Fertility and sterility 2000;74(1):130-3.
2000: Markku Seppala
The role of FIGO in the advancement of women's health - in the year 2000.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2000;70(1):175-82.
1999: Meerit Kämäräinen; Mervi Halttunen; Riitta Koistinen; Kristina von Boguslawsky; Karl von Smitten; Leif C Andersson; Markku Seppala
Expression of glycodelin in human breast and breast cancer.
International journal of cancer. Journal international du cancer 1999;83(6):738-42.
1999: Francesca Bernardi; Felice Petraglia; Markku Seppala; A Spinetti; S Bertolini; Lorenza Driul; Marco Ferdeghini; Andrea R Genazzani
GH, IGFBP-1, and IGFBP-3 response to oral glucose tolerance test in perimenopausal women: no influence of body mass index.
Maturitas 1999;33(2):163-9.
1999: Tarja Kalme; Mikko Loukovaara; Riitta Koistinen; Hannu Koistinen; M Angervo; Pekka Leinonen; Markku Seppala
Estradiol increases the production of sex hormone-binding globulin but not insulin-like growth factor binding protein-1 in cultured human hepatoma cells.
Fertility and sterility 1999;72(2):325-9.
1999: Markku Seppala
Glycodelins: biological activity in reproduction and differentiation.
Current opinion in obstetrics & gynecology 1999;11(3):261-3.
1999: Ksenija Gersak; Markku Seppala; Marija Us-Krasovec
The same luteinized granulosa-luteal cells from normal and superovulated human chorionic gonadotropin (hCG)-stimulated cycles contain hCG and insulin-like growth factor binding protein-1.
Fertility and sterility 1999;71(5):902-6.
1999: Hannu Koistinen; Riitta Koistinen; Markku Seppala; Tatiana V Burova; Yvan Choiset; Thomas Haertlé
Glycodelin and beta-lactoglobulin, lipocalins with a high structural similarity, differ in ligand binding properties.
FEBS letters 1999;450(1-2):158-62.
1999: Linda Tseng; Hui Hui Zhu; James Mazella; Hannu Koistinen; Markku Seppala
Relaxin stimulates glycodelin mRNA and protein concentrations in human endometrial glandular epithelial cells.
Molecular human reproduction 1999;5(4):372-5.
1998: Robert N Taylor; Jean-François Savouret; Christian Vaisse; Jean-Louis Vigne; Isabelle P Ryan; Daniela Hornung; Markku Seppala; Edwin Milgrom
Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells.
The Journal of clinical endocrinology and metabolism 1998;83(11):4006-12.
1998: Tuomo Karila; Hannu Koistinen; Markku Seppala; Riitta Koistinen; Timo Seppälä
Growth hormone induced increase in serum IGFBP-3 level is reversed by anabolic steroids in substance abusing power athletes.
Clinical endocrinology 1998;49(4):459-63.
1998: H Pere; Johanna Tapper; Markku Seppala; Sakari Knuutila; Ralf Butzow
Genomic alterations in fallopian tube carcinoma: comparison to serous uterine and ovarian carcinomas reveals similarity suggesting likeness in molecular pathogenesis.
Cancer research 1998;58(19):4274-6.
1998: Sergio Oehninger; Manish S Patankar; Markku Seppala; Gary F Clark
Involvement of selectin-like carbohydrate binding specificity in human gamete interaction.
Andrologia 1998;30(4-5):269-74.
1998: Johanna Tapper; Laura Sarantaus; Pia Vahteristo; Heli Nevanlinna; Samuli Hemmer; Markku Seppala; Sakari Knuutila; Ralf Butzow
Genetic changes in inherited and sporadic ovarian carcinomas by comparative genomic hybridization: extensive similarity except for a difference at chromosome 2q24-q32.
Cancer research 1998;58(13):2715-9.
1998: Markku Seppala; Hannu Koistinen; Riitta Koistinen; Erik Mandelin; Sergio Oehninger; Gary F Clark; Anne Dell; Howard R Morris
Glycodelins: role in regulation of reproduction, potential for contraceptive development and diagnosis of male infertility.
Human reproduction (Oxford, England) 1998;13 Suppl 3():262-9l; discussion 270.
1998: Meerit Kämäräinen; M Miettinen; Markku Seppala; Kristina von Boguslawsky; M S Benassi; Tom Böhling; Leif C Andersson
Epithelial expression of glycodelin in biphasic synovial sarcomas.
International journal of cancer. Journal international du cancer 1998;76(4):487-90.
1998: Francesca Bernardi; Felice Petraglia; Markku Seppala; A Spinetti; S Bertolini; Marco Ferdeghini; Andrea R Genazzani
Somatotropic axis and body weight in pre-menopausal and post-menopausal women: evidence for a neuroendocrine derangement, in absence of changes of insulin-like growth factor binding protein concentrations.
Human reproduction (Oxford, England) 1998;13(2):279-84.
1998: Markku Seppala; Hannu Koistinen; Erik Mandelin; Riitta Koistinen
[Importance of uterus and sperm glycodelins in the regulation of reproduction].
Duodecim; lääketieteellinen aikakauskirja 1998;114(8):761-7.
1998: Markku Seppala; H Bohn; Y Tatarinov
Glycodelins.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1998;19(3):213-20.
1997: KA Harrison; Markku Seppala
Obstetrics and gynaecology. Women and market forces.
Lancet 1997;350 Suppl 3():SIII16.
1997: Erik Mandelin; Hannu Koistinen; Riitta Koistinen; B Affandi; Markku Seppala
Levonorgestrel-releasing intrauterine device-wearing women express contraceptive glycodelin A in endometrium during midcycle: another contraceptive mechanism?
Human reproduction (Oxford, England) 1997;12(12):2671-5.
1997: Meerit Kämäräinen; Markku Seppala; Ismo Virtanen; Leif C Andersson
Expression of glycodelin in MCF-7 breast cancer cells induces differentiation into organized acinar epithelium.
Laboratory investigation; a journal of technical methods and pathology 1997;77(6):565-73.
1997: N Holst; K H Kierulf; Markku Seppala; R Koistinen; M B Jacobsen
Regulation of insulin-like growth factor-binding protein-1 and progesterone secretion from human granulosa-luteal cells: effects of octreotide and insulin.
Fertility and sterility 1997;68(3):478-82.
1997: Markku Seppala; Shibo Jiang; Nathan Strick; K Lin; Yun-Yao Li; Hannu Koistinen; Riitta Koistinen; A Robert Neurath
Glycodelins GdA and GdS modified by 3-hydroxyphthalic anhydride inhibit gp120-CD4 binding and HIV-1 infection in vitro.
Laboratory investigation; a journal of technical methods and pathology 1997;77(2):127-30.
1997: Manish S Patankar; Kemal Ozgur; Sergio Oehninger; Anne Dell; H Morris; Markku Seppala; Gary F Clark
Expression of glycans linked to natural killer cell inhibition on the human zona pellucida.
Molecular human reproduction 1997;3(6):501-5.
1997: Hannu Koistinen; Riitta Koistinen; Meerit Kämäräinen; Jarmo Salo; Markku Seppala
Multiple forms of messenger ribonucleic acid encoding glycodelin in male genital tract.
Laboratory investigation; a journal of technical methods and pathology 1997;76(5):683-90.
1997: Markku Seppala; Hannu Koistinen; Riitta Koistinen; Anne Dell; Howard R Morris; Sergio Oehninger; Gary F Clark
Glycodelins as regulators of early events of reproduction.
Clinical endocrinology 1997;46(4):381-6.
1997: Dennis R Stewart; M S Erikson; ME Erikson; Steven T Nakajima; James W Overstreet; Bill L Lasley; E P Amento; Markku Seppala
The role of relaxin in glycodelin secretion.
The Journal of clinical endocrinology and metabolism 1997;82(3):839-46.
1997: Gary F Clark; Anne Dell; Howard R Morris; Manish S Patankar; Sergio Oehninger; Markku Seppala
Viewing AIDS from a glycobiological perspective: potential linkages to the human fetoembryonic defence system hypothesis.
Molecular human reproduction 1997;3(1):5-13.
1997: Johanna Tapper; Ralf Bützow; Torsten Wahlström; Markku Seppala; Sakari Knuutila
Evidence for divergence of DNA copy number changes in serous, mucinous and endometrioid ovarian carcinomas.
British journal of cancer 1997;75(12):1782-7.
1997: Kristina Gemzell Danielsson; Marja-Liisa Swahn; Pär Westlund; E Johannisson; Markku Seppala; Marc Bygdeman
Effect of low daily doses of mifepristone on ovarian function and endometrial development.
Human reproduction (Oxford, England) 1997;12(1):124-31.
1996: Howard R Morris; Anne Dell; R L Easton; Maria Panico; Hannu Koistinen; Riitta Koistinen; Sergio Oehninger; Manish S Patankar; Markku Seppala; Gary F Clark
Gender-specific glycosylation of human glycodelin affects its contraceptive activity.
The Journal of biological chemistry 1996;271(50):32159-67.
1996: M Harrela; Hannu Koistinen; Jaakko Kaprio; Mikko Lehtovirta; Jaakko Tuomilehto; J Eriksson; L Toivanen; Markku Koskenvuo; P Leinonen; Riitta Koistinen; Markku Seppala
Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3.
The Journal of clinical investigation 1996;98(11):2612-5.
1996: Hannu Koistinen; Riitta Koistinen; Anne Dell; Howard R Morris; R L Easton; Manish S Patankar; Sergio Oehninger; Gary F Clark; Markku Seppala
Glycodelin from seminal plasma is a differentially glycosylated form of contraceptive glycodelin-A.
Molecular human reproduction 1996;2(10):759-65.
1996: Gary F Clark; Sergio Oehninger; Markku Seppala
Role for glycoconjugates in cellular communication in the human reproductive system.
Molecular human reproduction 1996;2(7):513-7.
1996: R G Hahn; J Olsson; K Englund; Markku Seppala
Serum levels of endometrial proteins during transcervical resection of the endometrium.
British journal of obstetrics and gynaecology 1996;103(5):442-5.
1996: Meerit Kämäräinen; I Leivo; Riitta Koistinen; M Julkunen; U Karvonen; Eeva-Marja Rutanen; Markku Seppala
Normal human ovary and ovarian tumors express glycodelin, a glycoprotein with immunosuppressive and contraceptive properties.
The American journal of pathology 1996;148(5):1435-43.
1996: A Suikkari; Vivien MacLachlan; R Koistinen; Markku Seppala; D Healy
Double-blind placebo controlled study: human biosynthetic growth hormone for assisted reproductive technology.
Fertility and sterility 1996;65(4):800-5.
1996: Hannu Koistinen; Riitta Koistinen; L Selenius; Q Ylikorkala; Markku Seppala
Effect of marathon run on serum IGF-I and IGF-binding protein 1 and 3 levels.
Journal of applied physiology (Bethesda, Md. : 1985) 1996;80(3):760-4.
1996: Seppo Heinonen; Markku Ryynänen; Pertti Kirkinen; I Penttilä; K Syrjänen; Markku Seppala; S Saarikoski
Prenatal screening for congenital nephrosis in east Finland: results and impact on the birth prevalence of the disease.
Prenatal diagnosis 1996;16(3):207-13.
1996: Gary F Clark; Sergio Oehninger; Manish S Patankar; Riitta Koistinen; Anne Dell; Howard R Morris; Hannu Koistinen; Markku Seppala
A role for glycoconjugates in human development: the human feto-embryonic defence system hypothesis.
Human reproduction (Oxford, England) 1996;11(3):467-73.
1996: E Vihervuori; M Virtanen; Hannu Koistinen; Riitta Koistinen; Markku Seppala; Martti A Siimes
Hemoglobin level is linked to growth hormone-dependent proteins in short children.
Blood 1996;87(5):2075-81.
1996: Kristina Gemzell Danielsson; Pär Westlund; E Johannisson; Marja-Liisa Swahn; Marc Bygdeman; Markku Seppala
Effect of low weekly doses of mifepristone on ovarian function and endometrial development.
Human reproduction (Oxford, England) 1996;11(2):256-64.
1996: Markku Seppala; Aila Tiitinen; Kari Teramo; K Raivio
[Assisted reproduction and risks of superovulation].
Duodecim; lääketieteellinen aikakauskirja 1996;112(4):245-7.
1995: Markku Seppala; Aila Tiitinen
Endometrial responses to corpus luteum products in cycles with induced ovulation: theoretical and practical considerations.
Human reproduction (Oxford, England) 1995;10 Suppl 2():67-76.
1995: Pertti Ebeling; Ulf-Hakan Stenman; Markku Seppala; Veikko Koivisto
Androgens and insulin resistance in type 1 diabetic men.
Clinical endocrinology 1995;43(5):601-7.
1995: Anne Dell; Howard R Morris; R L Easton; Maria Panico; Manish S Patankar; S Oehniger; Riitta Koistinen; Hannu Koistinen; Markku Seppala; Gary F Clark
Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities.
The Journal of biological chemistry 1995;270(41):24116-26.
1995: D Hamilton-Fairley; D White; M Griffiths; Victor Anyaoku; Riitta Koistinen; Markku Seppala; Stephen Franks
Diurnal variation of sex hormone binding globulin and insulin-like growth factor binding protein-1 in women with polycystic ovary syndrome.
Clinical endocrinology 1995;43(2):159-65.
1995: Pertti Ebeling; Ulf-Hakan Stenman; Markku Seppala; Veikko Koivisto
Acute hyperinsulinemia, androgen homeostasis and insulin sensitivity in healthy man.
The Journal of endocrinology 1995;146(1):63-9.
1995: Maija Tulppala; M Julkunen; Aila Tiitinen; Ulf-Hakan Stenman; Markku Seppala
Habitual abortion is accompanied by low serum levels of placental protein 14 in the luteal phase of the fertile cycle.
Fertility and sterility 1995;63(4):792-5.
1995: Aila Tiitinen; L M Husa; Maija Tulppala; N Simberg; Markku Seppala
The effect of cryopreservation in prevention of ovarian hyperstimulation syndrome.
British journal of obstetrics and gynaecology 1995;102(4):326-9.
1995: Shayesteh Jahanfar; John A Eden; P Warren; Markku Seppala; T V Nguyen
A twin study of polycystic ovary syndrome.
Fertility and sterility 1995;63(3):478-86.
1995: Sergio Oehninger; CC Coddington; Gary Hodgen; Markku Seppala
Factors affecting fertilization: endometrial placental protein 14 reduces the capacity of human spermatozoa to bind to the human zona pellucida.
Fertility and sterility 1995;63(2):377-83.
1994: D M Morrow; N Xiong; R R Getty; M Z Ratajczak; D Morgan; Markku Seppala; L Riittinen; A M Gewirtz; Mark L Tykocinski
Hematopoietic placental protein 14. An immunosuppressive factor in cells of the megakaryocytic lineage.
The American journal of pathology 1994;145(6):1485-95.
1994: T Miettinen; Aila Tiitinen; Riitta Koistinen; M Julkunen; Markku Seppala
Serum placental protein 14 concentrations are similar in the first trimester pregnancies of women after pituitary down-regulation with a gonadotrophin-releasing hormone agonist and normal cycles with frozen embryo transfers.
Human reproduction (Oxford, England) 1994;9(12):2429-31.
1994: RM Anttila; Riitta Koistinen; Markku Seppala; Hannu Koistinen; Martti A Siimes
Insulin-like growth factor I and insulin-like growth factor binding protein 3 as determinants of blood hemoglobin concentration in healthy subjects.
Pediatric research 1994;36(6):745-8.
1994: K Sarvas; M Angervo; Riitta Koistinen; Aila Tiitinen; Markku Seppala
Prostaglandin F2 alpha stimulates release of insulin-like growth factor binding protein-3 from cultured human granulosa-luteal cells.
Human reproduction (Oxford, England) 1994;9(9):1643-6.
1994: M Kämäräinen; L Riittinen; Markku Seppala; Aarno Palotie; Leif C Andersson
Progesterone-associated endometrial protein--a constitutive marker of human erythroid precursors.
Blood 1994;84(2):467-73.
1994: Markku Seppala; Riitta Koistinen; Eeva-Marja Rutanen
Uterine endocrinology and paracrinology: insulin-like growth factor binding protein-1 and placental protein 14 revisited.
Human reproduction (Oxford, England) 1994;9(5):917-25.
1994: Hannu Koistinen; Markku Seppala; Riitta Koistinen
Different forms of insulin-like growth factor-binding protein-3 detected in serum and seminal plasma by immunofluorometric assay with monoclonal antibodies.
Clinical chemistry 1994;40(4):531-6.
1994: L D Klentzeris; J N Bulmer; Markku Seppala; Li Tiantian; MA Warren; I D Cooke
Placental protein 14 in cycles with normal and retarded endometrial differentiation.
Human reproduction (Oxford, England) 1994;9(3):394-8.
1994: V Insler; Amihai Barash; Zeev Shoham; Riitta Koistinen; Markku Seppala; M Hen; Bruno Lunenfeld; ZVI ZADIK
Overnight secretion pattern of growth hormone, sex hormone binding globulin, insulin-like growth factor-1 and its binding protein in obese and non-obese women with polycystic ovarian disease.
Israel journal of medical sciences 1994;30(1):42-7.
1993: Markku Seppala; M Julkunen; Eeva-Marja Rutanen
Endometrial protein secretion during the peri-implantation phase and early pregnancy.
Acta Europaea fertilitatis 1993;24(5):225-8.
1993: D Hamilton-Fairley; D Kiddy; Victor Anyaoku; Riitta Koistinen; Markku Seppala; Stephen Franks
Response of sex hormone binding globulin and insulin-like growth factor binding protein-1 to an oral glucose tolerance test in obese women with polycystic ovary syndrome before and after calorie restriction.
Clinical endocrinology 1993;39(3):363-7.
1993: Aila Tiitinen; A Tenhunen; Markku Seppala
Ovarian electrocauterization causes LH-regulated but not insulin-regulated endocrine changes.
Clinical endocrinology 1993;39(2):181-4.
1993: T H Hakala-Ala-Pietilä; Riitta Koistinen; Riitta Salonen; Markku Seppala
Elevated second-trimester amniotic fluid concentration of insulin-like growth factor binding protein-1 in fetal growth retardation.
American journal of obstetrics and gynecology 1993;169(1):35-9.
1993: Aila Tiitinen; TJ Laatikainen; Markku Seppala
Serum levels of insulin-like growth factor binding protein-1 and ovulatory responses to clomiphene citrate in women with polycystic ovarian disease.
Fertility and sterility 1993;60(1):58-62.
1993: Riitta Koistinen; M Angervo; P Leinonen; T Hakala; Markku Seppala
Phosphorylation of insulin-like growth factor-binding protein-1 increases in human amniotic fluid and decidua from early to late pregnancy.
Clinica chimica acta; international journal of clinical chemistry 1993;215(2):189-99.
1993: M Angervo; M Tiihonen; P Leinonen; M Välimäki; Markku Seppala
Thyroxine treatment increases circulating levels of insulin-like growth factor binding protein-1: a placebo-controlled study.
Clinical endocrinology 1993;38(5):547-51.
1993: Helen D Mason; R Margara; Robert M L Winston; Markku Seppala; Riitta Koistinen; Stephen Franks
Insulin-like growth factor-I (IGF-I) inhibits production of IGF-binding protein-1 while stimulating estradiol secretion in granulosa cells from normal and polycystic human ovaries.
The Journal of clinical endocrinology and metabolism 1993;76(5):1275-9.
1993: M Angervo; J Toivonen; P Leinonen; M Välimäki; Markku Seppala
Thyroxine withdrawal is accompanied by decreased circulating levels of insulin-like growth factor-binding protein-1 in thyroidectomized patients.
The Journal of clinical endocrinology and metabolism 1993;76(5):1199-201.
1993: Riitta Koistinen; M Angervo; P Leinonen; Markku Seppala
Phosphorylation of insulin-like growth factor-binding protein-1 from different sources.
Growth regulation 1993;3(1):34-7.
1993: V Insler; Zeev Shoham; Amihai Barash; Riitta Koistinen; Markku Seppala; M Hen; B Lunenfeld; Z Zadik
Polycystic ovaries in non-obese and obese patients: possible pathophysiological mechanism based on new interpretation of facts and findings.
Human reproduction (Oxford, England) 1993;8(3):379-84.
1993: Marja-Liisa Swahn; Marc Bygdeman; Markku Seppala; E Johannisson; S Cekan
Effect of tamoxifen alone and in combination with RU 486 on the endometrium in the mid-luteal phase.
Human reproduction (Oxford, England) 1993;8(2):193-200.
1993: Meerit Kämäräinen; I Leivo; M Julkunen; Markku Seppala
Localization of progesterone-associated endometrial protein mRNA by in-situ hybridization in human pregnancy decidua, endometriosis and borderline endometrioid adenoma.
Journal of molecular endocrinology 1993;10(1):71-7.
1993: M Angervo; P Leinonen; Riitta Koistinen; M Julkunen; Markku Seppala
Tri-iodothyronine and cycloheximide enhance insulin-like growth factor-binding protein-1 gene expression in human hepatoma cells.
Journal of molecular endocrinology 1993;10(1):7-13.
1993: Eli Y Adashi; Carol E Resnick; Ronald G Rosenfeld; D R Powell; Riitta Koistinen; E M Rutanen; Markku Seppala
Insulin-like growth factor (IGF) binding protein-1 is an antigonadotropin: evidence that optimal follicle-stimulating hormone action in ovarian granulosa cells is contingent upon amplification by endogenously-derived IGFs.
Advances in experimental medicine and biology 1993;343():377-85.
1992: Helen D Mason; D Willis; Jeff M P Holly; S C Cwyfan-Hughes; Markku Seppala; Stephen Franks
Inhibitory effects of insulin-like growth factor-binding proteins on steroidogenesis by human granulosa cells in culture.
Molecular and cellular endocrinology 1992;89(1-2):R1-4.
1992: Zvi Laron; A M Suikkari; B Klinger; Aviva Silbergeld; Athalia Pertzelan; Markku Seppala; V A Koivisto
Growth hormone and insulin-like growth factor regulate insulin-like growth factor-binding protein-1 in Laron type dwarfism, growth hormone deficiency and constitutional short stature.
Acta endocrinologica 1992;127(4):351-8.
1992: Michael J Reed; A Christodoulides; R Koistinen; Markku Seppala; J D Teale; Margaret W Ghilchik
The effect of endocrine therapy with medroxyprogesterone acetate, 4-hydroxyandrostenedione or tamoxifen on plasma concentrations of insulin-like growth factor (IGF)-I, IGF-II and IGFBP-1 in women with advanced breast cancer.
International journal of cancer. Journal international du cancer 1992;52(2):208-12.
1992: Eeva-Marja Rutanen; Markku Seppala
Insulin-like growth factor binding protein-1 in female reproductive functions.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1992;39(1):3-9.
1992: A M Suikkari; I Leivo; Meerit Kämäräinen; H Holthöfer; Markku Seppala; M Julkunen; Riitta Koistinen
Expression of insulin-like growth factor binding protein-1 mRNA in human fetal kidney.
Kidney international 1992;42(3):749-54.
1992: Hannu Martikainen; Riitta Koistinen; Markku Seppala
The effect of estrogen level on glucose-induced changes in serum insulin-like growth factor binding protein-1 concentration.
Fertility and sterility 1992;58(3):543-6.
1992: Jehoshua Dor; N Costritsci; C Pariente; J Rabinovici; Shlomo Mashiach; Bruno Lunenfeld; H Kaneti; Markku Seppala; R Koistinen; Avraham Karasik
Insulin-like growth factor-I and follicle-stimulating hormone suppress insulin-like growth factor binding protein-1 secretion by human granulosa-luteal cells.
The Journal of clinical endocrinology and metabolism 1992;75(3):969-71.
1992: M Angervo; Riitta Koistinen; Markku Seppala
Epidermal growth factor stimulates production of insulin-like growth factor-binding protein-1 in human granulosa-luteal cells.
The Journal of endocrinology 1992;134(1):127-31.
1992: Markku Seppala; M Julkunen; L Riittinen; Riitta Koistinen
Endometrial proteins: a reappraisal.
Human reproduction (Oxford, England) 1992;7 Suppl 1():31-8.
1992: Jehoshua Dor; I Ben-Shlomo; Bruno Lunenfeld; C Pariente; David Levran; Avraham Karasik; Markku Seppala; Shlomo Mashiach
Insulin-like growth factor-I (IGF-I) may not be essential for ovarian follicular development: evidence from IGF-I deficiency.
The Journal of clinical endocrinology and metabolism 1992;74(3):539-42.
1992: Philippe Robert Koninckx; L Riittinen; Markku Seppala; F J Cornillie
CA-125 and placental protein 14 concentrations in plasma and peritoneal fluid of women with deeply infiltrating pelvic endometriosis.
Fertility and sterility 1992;57(3):523-30.
1992: L Nylund; O Gustafson; B Lindblom; Ake Pousette; Markku Seppala; L Riittinen; E Akerlöf
Placental protein 14 in human in-vitro fertilization early pregnancies.
Human reproduction (Oxford, England) 1992;7(1):128-30.
1991: N Okamoto; A Uchida; K Takakura; Y Kariya; Hideharu Kanzaki; L Riittinen; Riitta Koistinen; Markku Seppala; T Mori
Suppression by human placental protein 14 of natural killer cell activity.
American journal of reproductive immunology (New York, N.Y. : 1989) 1991;26(4):137-42.
1991: F J Cornillie; J M Lauweryns; Markku Seppala; L Riittinen; Philippe Robert Koninckx
Expression of endometrial protein PP14 in pelvic and ovarian endometriotic implants.
Human reproduction (Oxford, England) 1991;6(10):1411-5.
1991: Hannu Martikainen; Juha S Tapanainen; L Rönnberg; Antti Kauppila; P Selenius; Markku Seppala
Insulin-like growth factor binding protein-1 and ovarian stimulation.
Human reproduction (Oxford, England) 1991;6(9):1220-2.
1991: Meerit Kämäräinen; M Julkunen; Markku Seppala
HinfI polymorphism in the human progesterone associated endometrial protein (PAEP) gene.
Nucleic acids research 1991;19(18):5092.
1991: M Angervo; Riitta Koistinen; A M Suikkari; Markku Seppala
Insulin-like growth factor binding protein-1 inhibits the DNA amplification induced by insulin-like growth factor I in human granulosa-luteal cells.
Human reproduction (Oxford, England) 1991;6(6):770-3.
1991: Juha S Tapanainen; L Rönnberg; Hannu Martikainen; M Reinilä; Riitta Koistinen; Markku Seppala
Short and long term effects of growth hormone on circulating levels of insulin-like growth factor-I (IGF-I), IGF-binding protein-1, and insulin: a placebo-controlled study.
The Journal of clinical endocrinology and metabolism 1991;73(1):71-4.
1991: K Ruutiainen; Markku Seppala
Polycystic ovary syndrome: evolution of a concept.
Current opinion in obstetrics & gynecology 1991;3(3):326-35.
1991: A M Suikkari; Aila Tiitinen; Ulf-Hakan Stenman; Markku Seppala; TJ Laatikainen
Oral contraceptives increase insulin-like growth factor binding protein-1 concentration in women with polycystic ovarian disease.
Fertility and sterility 1991;55(5):895-9.
1991: Markku Seppala; M Angervo; Riitta Koistinen; L Riittinen; M Julkunen
Human endometrial protein secretion relative to implantation.
Baillière's clinical obstetrics and gynaecology 1991;5(1):61-72.
1991: L Riittinen; O Närvänen; Ismo Virtanen; Markku Seppala
Monoclonal antibodies against endometrial protein PP14 and their use for purification and radioimmunoassay of PP14.
Journal of immunological methods 1991;136(1):85-90.
1991: Bruno Lunenfeld; C Pariente; Jehoshua Dor; Y Menashe; Markku Seppala; H Mortman; V Insler
Modern aspects of ovulation induction.
Annals of the New York Academy of Sciences 1991;626():207-16.
1991: Stephen Franks; D Kiddy; P Sharp; A Singh; M Reed; Markku Seppala; Riitta Koistinen; D Hamilton-Fairley
Obesity and polycystic ovary syndrome.
Annals of the New York Academy of Sciences 1991;626():201-6.
1991: Markku Seppala; M Yajima; Riitta Koistinen; M Angervo; L Riittinen; A M Suikkari; P Selenius; M Julkunen
Endometrial proteins as local regulators of human endometrial function and their appearance in serum: clinical applications.
Annals of the New York Academy of Sciences 1991;626():312-20.
1991: M Julkunen; Markku Seppala; Olli A Jänne
Molecular cloning of complementary DNAs for two human endometrial proteins and cellular localization of their messenger RNAs.
Annals of the New York Academy of Sciences 1991;626():284-94.
1991: A M Suikkari; M Angervo; Riitta Koistinen; J Jalkanen; Markku Seppala
Insulin-like growth factor-binding protein-1 (IGFBP-1) in the human ovary.
Annals of the New York Academy of Sciences 1991;626():184-8.
1990: Riitta Koistinen; O Itkonen; P Selenius; Markku Seppala
Insulin-like growth factor-binding protein-1 inhibits binding of IGF-I on fetal skin fibroblasts but stimulates their DNA synthesis.
Biochemical and biophysical research communications 1990;173(1):408-15.
1990: TJ Laatikainen; Leena Anttila; A M Suikkari; K Ruutiainen; Risto Erkkola; Markku Seppala
Effect of naloxone on plasma insulin, insulin-like growth factor I, and its binding protein 1 in patients with polycystic ovarian disease.
Fertility and sterility 1990;54(3):434-7.
1990: Markku Seppala; A M Suikkari; Riitta Koistinen; L Riittinen; M Julkunen
Endometrial protein secretion with respect to endometrial and ovarian function.
European journal of obstetrics, gynecology, and reproductive biology 1990;36(3):250-7.
1990: M Julkunen; Riitta Koistinen; A M Suikkari; Markku Seppala; Olli A Jänne
Identification by hybridization histochemistry of human endometrial cells expressing mRNAs encoding a uterine beta-lactoglobulin homologue and insulin-like growth factor-binding protein-1.
Molecular endocrinology (Baltimore, Md.) 1990;4(5):700-7.
1990: Riitta Koistinen; A M Suikkari; Aila Tiitinen; K Kontula; Markku Seppala
Human granulosa cells contain insulin-like growth factor-binding protein (IGF BP-1) mRNA.
Clinical endocrinology 1990;32(5):635-40.
1990: D J Brock; L Barron; S Holloway; William A Liston; S G Hillier; Markku Seppala
First-trimester maternal serum biochemical indicators in Down syndrome.
Prenatal diagnosis 1990;10(4):245-51.
1990: Pentti Lehtovirta; Kalevi Kairemo; K Liewendahl; Markku Seppala
Immunolymphoscintigraphy and immunoscintigraphy of ovarian and fallopian tube cancer using F(ab')2 fragments of monoclonal antibody OC 125.
Cancer research 1990;50(3 Suppl):937s-940s.
1990: A Singh; D Hamilton-Fairley; Riitta Koistinen; Markku Seppala; V H James; Stephen Franks; Michael J Reed
Effect of insulin-like growth factor-type I (IGF-I) and insulin on the secretion of sex hormone binding globulin and IGF-I binding protein (IBP-I) by human hepatoma cells.
The Journal of endocrinology 1990;124(2):R1-3.
1989: D S Kiddy; D Hamilton-Fairley; Markku Seppala; Riitta Koistinen; V H James; Michael J Reed; Stephen Franks
Diet-induced changes in sex hormone binding globulin and free testosterone in women with normal or polycystic ovaries: correlation with serum insulin and insulin-like growth factor-I.
Clinical endocrinology 1989;31(6):757-63.
1989: J Jalkanen; A M Suikkari; Riitta Koistinen; Ralf Bützow; Olli Ritvos; Markku Seppala; T Ranta
Regulation of insulin-like growth factor-binding protein-1 production in human granulosa-luteal cells.
The Journal of clinical endocrinology and metabolism 1989;69(6):1174-9.
1989: Tiina Alitalo; Kimmo Kontula; Riitta Koistinen; K Aalto-Setälä; M Julkunen; Olli A Jänne; Markku Seppala; Albert de La Chapelle
The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism.
Human genetics 1989;83(4):335-8.
1989: S Telimaa; Antti Kauppila; L Rönnberg; A M Suikkari; Markku Seppala
Elevated serum levels of endometrial secretory protein PP14 in patients with advanced endometriosis. Suppression by treatment with danazol and high-dose medroxyprogesterone acetate.
American journal of obstetrics and gynecology 1989;161(4):866-71.
1989: L Riittinen; M Julkunen; Markku Seppala; Riitta Koistinen; M L Huhtala
Purification and characterization of endometrial protein PP14 from mid-trimester amniotic fluid.
Clinica chimica acta; international journal of clinical chemistry 1989;184(1):19-29.
1989: L Riittinen; Ulf-Hakan Stenman; Henrik Alfthan; A M Suikkari; H Bohn; Markku Seppala
Time-resolved immunofluorometric assay for placental protein 14.
Clinica chimica acta; international journal of clinical chemistry 1989;183(2):115-23.
1989: Markku Seppala; H Martikainen; L Rönnberg; L Riittinen; A Kauppila
Suppression of prolactin secretion during ovarian hyperstimulation is followed by elevated serum levels of endometrial protein PP14 in the late luteal phase.
Human reproduction (Oxford, England) 1989;4(4):389-91.
1989: A M Suikkari; J Jalkanen; Riitta Koistinen; Ralf Bützow; Olli Ritvos; T Ranta; Markku Seppala
Human granulosa cells synthesize low molecular weight insulin-like growth factor-binding protein.
Endocrinology 1989;124(2):1088-90.
1989: A M Suikkari; K Ruutiainen; Risto Erkkola; Markku Seppala
Low levels of low molecular weight insulin-like growth factor-binding protein in patients with polycystic ovarian disease.
Human reproduction (Oxford, England) 1989;4(2):136-9.
1989: A M Suikkari; Timo Sane; Markku Seppala; Hannele Yki-Järvinen; Sirkka-Liisa Karonen; Veikko Koivisto
Prolonged exercise increases serum insulin-like growth factor-binding protein concentrations.
The Journal of clinical endocrinology and metabolism 1989;68(1):141-4.
1989: A M Suikkari; Veikko Koivisto; Riitta Koistinen; Markku Seppala; Hannele Yki-Järvinen
Dose-response characteristics for suppression of low molecular weight plasma insulin-like growth factor-binding protein by insulin.
The Journal of clinical endocrinology and metabolism 1989;68(1):135-40.
1988: M Julkunen; Markku Seppala; Olli A Jänne
Complete amino acid sequence of human placental protein 14: a progesterone-regulated uterine protein homologous to beta-lactoglobulins.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):8845-9.
1988: Ralf Bützow; V P Lehto; Olli Ritvos; T Ranta; Markku Seppala
Regulation of the production of placental protein 5 by human endometrial stromal cells; the role of prostaglandins E2 and F2 alpha.
Molecular and cellular endocrinology 1988;60(2-3):137-43.
1988: M Julkunen; Riitta Koistinen; K Aalto-Setälä; Markku Seppala; Olli A Jänne; Kimmo Kontula
Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA.
FEBS letters 1988;236(2):295-302.
1988: Ralf Bützow; Henrik Alfthan; Ulf-Hakan Stenman; A M Suikkari; H Bohn; Markku Seppala
Immunofluorometric demonstration and quantification of placental protein 5 in the absence of pregnancy.
Clinical chemistry 1988;34(8):1591-3.
1988: Ralf Bützow; Ismo Virtanen; Markku Seppala; O Närvänen; Ulf-Hakan Stenman; A Ristimäki; H Bohn
Monoclonal antibodies reacting with placental protein 5: use in radioimmunoassay, Western blot analysis, and immunohistochemistry.
The Journal of laboratory and clinical medicine 1988;111(2):249-56.
1988: A M Suikkari; Veikko Koivisto; E M Rutanen; Hannele Yki-Järvinen; Sirkka-Liisa Karonen; Markku Seppala
Insulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein.
The Journal of clinical endocrinology and metabolism 1988;66(2):266-72.
1988: Ralf Bützow; M L Huhtala; H Bohn; Ismo Virtanen; Markku Seppala
Purification and characterization of placental protein 5.
Biochemical and biophysical research communications 1988;150(1):483-90.
1988: Markku Seppala; M Julkunen; A Koskimies; TJ Laatikainen; Ulf-Hakan Stenman; M L Huhtala
Proteins of the human endometrium. Basic and clinical studies toward a blood test for endometrial function.
Annals of the New York Academy of Sciences 1988;541():432-44.
1988: H Halila; Pentti Lehtovirta; Ulf-Hakan Stenman; Markku Seppala
CA 125 in the follow-up of patients with ovarian cancer.
Acta obstetricia et gynecologica Scandinavica 1988;67(1):53-8.
1988: Volker Briese; G Than; D Richter; K Iino; Markku Seppala
[Placental protein 5 and pregnancy zone protein in ovarian cysts and benign cystic ovarian tumors].
Zentralblatt für Gynäkologie 1988;110(13):821-3.
1988: Markku Seppala; L Riittinen; M Julkunen; Riitta Koistinen; T Wahlström; K Iino; Henrik Alfthan; Ulf-Hakan Stenman; M L Huhtala
Structural studies, localization in tissue and clinical aspects of human endometrial proteins.
Journal of reproduction and fertility. Supplement 1988;36():127-41.
1988: A L Koskimies; Markku Seppala
[Life beneath the microscope].
Duodecim; lääketieteellinen aikakauskirja 1988;104(17):1305-9.
1988: Markku Seppala; A M Suikkari; M Julkunen
Human endometrial proteins.
Reproduction, nutrition, development 1988;28(6B):1649-54.
1987: Markku Seppala; Henrik Alfthan; E Vartiainen; Ulf-Hakan Stenman
The post-menopausal uterus: the effect of hormone replacement therapy on the serum levels of secretory endometrial protein PP14/beta-lactoglobulin homologue.
Human reproduction (Oxford, England) 1987;2(8):741-3.
1987: G Than; Markku Seppala; M Julkunen; D Szabo; J Bodis; A Szilagyi; I Csaba
The effect of Danazol on the circulating levels of 34K insulin-like growth factor-binding protein (PP12) and endometrial secretory protein PP14.
Human reproduction (Oxford, England) 1987;2(7):549-51.
1987: Markku Seppala; L Rönnberg; S L Karonen; Antti Kauppila
Micronized oral progesterone increases the circulating level of endometrial secretory PP14/beta-lactoglobulin homologue.
Human reproduction (Oxford, England) 1987;2(6):453-5.
1987: Harriet von Koskull; P Ammälä; M L Huhtala; Markku Seppala
Localization of insulin-like growth factor-binding protein and endometrial beta-lactoglobulin in cultured decidual and chorionic villus cells.
Human reproduction (Oxford, England) 1987;2(5):431-4.
1987: R Koistinen; Ulf-Hakan Stenman; H Alfthan; Markku Seppala
Time-resolved immunofluorometric assay of 34-kDa somatomedin-binding protein.
Clinical chemistry 1987;33(7):1126-8.
1987: M L Huhtala; Markku Seppala; Ale Närvänen; P Palomäki; M Julkunen; H Bohn
Amino acid sequence homology between human placental protein 14 and beta-lactoglobulins from various species.
Endocrinology 1987;120(6):2620-2.
1987: R Koistinen; M L Huhtala; Ulf-Hakan Stenman; Markku Seppala
Purification of placental protein PP12 from human amniotic fluid and its comparison with PP12 from placenta by immunological, physicochemical and somatomedin-binding properties.
Clinica chimica acta; international journal of clinical chemistry 1987;164(3):293-303.
1987: A M Suikkari; E M Rutanen; Markku Seppala
Circulating levels of immunoreactive insulin-like growth factor-binding protein in non-pregnant women.
Human reproduction (Oxford, England) 1987;2(4):297-300.
1987: R Bützow; I Huhtaniemi; R Clayton; T Wahlström; L C Andersson; Markku Seppala
Cultured mammary carcinoma cells contain gonadotropin-releasing hormone-like immunoreactivity, GnRH binding sites and chorionic gonadotropin.
International journal of cancer. Journal international du cancer 1987;39(4):498-501.
1987: Ulf-Hakan Stenman; H Alfthan; T Ranta; E Vartiainen; J Jalkanen; Markku Seppala
Serum levels of human chorionic gonadotropin in nonpregnant women and men are modulated by gonadotropin-releasing hormone and sex steroids.
The Journal of clinical endocrinology and metabolism 1987;64(4):730-6.
1987: H Halila; A M Suikkari; Markku Seppala
The effect of hysterectomy on serum CA 125 levels in patients with adenomyosis and uterine fibroids.
Human reproduction (Oxford, England) 1987;2(3):265-6.
1987: Markku Seppala; M Purhonen
The use of hCG and other pregnancy proteins in the diagnosis of ectopic pregnancy.
Clinical obstetrics and gynecology 1987;30(1):148-54.
1987: M Julkunen; Markku Seppala
[A novel protein related to endometrial function].
Duodecim; lääketieteellinen aikakauskirja 1987;103(6):315-20.
1987: G Than; A Tiitinen; Markku Seppala; I Csaba; H Bohn
Placental protein 10: levels in benign and malignant ovarian cyst fluids and pleural exudates.
Archives of gynecology 1987;240(2):115-8.
1987: A Tiitinen; Ralf Bützow; Riitta Koistinen; Markku Seppala
Human endometrium and menstrual fluid contain placental protein 10 (PP10).
Archives of gynecology 1987;240(2):107-13.
1987: G Than; Markku Seppala; I Csaba; K Iino; V Briese
Placental protein 5 in benign and malignant ovarian cyst fluids.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1987;8(4):230-1.
1987: E M Rutanen; Riitta Koistinen; Markku Seppala; M Julkunen; A M Suikkari; M L Huhtala
Progesterone-associated proteins PP12 and PP14 in the human endometrium.
Journal of steroid biochemistry 1987;27(1-3):25-31.
1987: Ulf-Hakan Stenman; Markku Seppala
Biochemical and immunologic diagnosis of cancer. Ovarian cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1987;8(2-3):109-12.
1987: Aila Tiitinen; G N Than; K Iino; H Halila; Markku Seppala
Placental protein 10 (PP10) in the serum of patients with trophoblastic and nontrophoblastic gynaecological tumours.
Archives of gynecology and obstetrics 1987;241(1):43-6.
1987: Markku Seppala; G Than
Insulin-like growth factor-binding protein PP12 in ovarian cyst fluid.
Archives of gynecology and obstetrics 1987;241(1):33-5.
1986: M L Huhtala; Riitta Koistinen; P Palomäki; P Partanen; H Bohn; Markku Seppala
Biologically active domain in somatomedin-binding protein.
Biochemical and biophysical research communications 1986;141(1):263-70.
1986: K Iino; Markku Seppala; P K Heinonen; P Sipponen; E M Rutanen
Elevated levels of a somatomedin-binding protein PP12 in patients with ovarian cancer.
Cancer 1986;58(10):2294-7.
1986: Markku Seppala; K Iino; E M Rutanen
Placental proteins in oncology.
Clinics in obstetrics and gynaecology 1986;13(3):593-610.
1986: Aila Tiitinen; T Wahlström; M Julkunen; Markku Seppala
The content and immunohistochemical localization of placental protein 10 (PP10) in the fallopian tube.
British journal of obstetrics and gynaecology 1986;93(9):924-7.
1986: Ralf Bützow; Henrik Alfthan; M Julkunen; E M Rutanen; H Bohn; Markku Seppala
Human endometrium and menstrual fluid contain placental protein 5 (PP5).
Human reproduction (Oxford, England) 1986;1(5):287-9.
1986: K Iino; Jari Sjöberg; Markku Seppala
Elevated circulating levels of a decidual protein, placental protein 12, in preeclampsia.
Obstetrics and gynecology 1986;68(1):58-60.
1986: M Julkunen; T Wahlström; Markku Seppala
Human fallopian tube contains placental protein 14.
American journal of obstetrics and gynecology 1986;154(5):1076-9.
1986: M Julkunen; R Koistinen; Jari Sjöberg; E M Rutanen; T Wahlström; Markku Seppala
Secretory endometrium synthesizes placental protein 14.
Endocrinology 1986;118(5):1782-6.
1986: H Halila; Ulf-Hakan Stenman; Markku Seppala
Ovarian cancer antigen CA 125 levels in pelvic inflammatory disease and pregnancy.
Cancer 1986;57(7):1327-9.
1986: R Koistinen; N Kalkkinen; M L Huhtala; Markku Seppala; H Bohn; E M Rutanen
Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid.
Endocrinology 1986;118(4):1375-8.
1986: E M Rutanen; R Koistinen; Jari Sjöberg; M Julkunen; T Wahlström; H Bohn; Markku Seppala
Synthesis of placental protein 12 by human endometrium.
Endocrinology 1986;118(3):1067-71.
1986: M Julkunen; Dan Apter; Markku Seppala; Ulf-Hakan Stenman; H Bohn
Serum levels of placental protein 14 reflect ovulation in nonconceptional menstrual cycles.
Fertility and sterility 1986;45(1):47-50.
1986: K Iino; M Julkunen; Jari Sjöberg; Markku Seppala
Is decidua affected in gestational hypertension? Indication by elevated PP14 levels.
Acta obstetricia et gynecologica Scandinavica 1986;65(4):367-70.
1986: M Julkunen; R S Raikar; S G Joshi; H Bohn; Markku Seppala
Placental protein 14 and progestagen-dependent endometrial protein are immunologically indistinguishable.
Human reproduction (Oxford, England) 1986;1(1):7-8.
1985: M Julkunen; E M Rutanen; A Koskimies; T Ranta; H Bohn; Markku Seppala
Distribution of placental protein 14 in tissues and body fluids during pregnancy.
British journal of obstetrics and gynaecology 1985;92(11):1145-51.
1985: A Tiitinen; T Laatikainen; E M Rutanen; T Ranta; R Koistinen; H Bohn; Markku Seppala
Placental protein 10 (PP10) in normal pregnancy and cholestasis of pregnancy.
British journal of obstetrics and gynaecology 1985;92(11):1137-40.
1985: E M Rutanen; R Koistinen; T Wahlström; H Bohn; T Ranta; Markku Seppala
Synthesis of placental protein 12 by human decidua.
Endocrinology 1985;116(4):1304-9.
1985: Markku Seppala; A I Koskimies
[In vitro fertilization].
Duodecim; lääketieteellinen aikakauskirja 1985;101(15):1464-74.
1985: Markku Seppala
The world collaborative report on in vitro fertilization and embryo replacement: current state of the art in January 1984.
Annals of the New York Academy of Sciences 1985;442():558-63.
1985: Hannele Yki-Järvinen; T Wahlström; Markku Seppala
Human endometrium contains relaxin that is progesterone-dependent.
Acta obstetricia et gynecologica Scandinavica 1985;64(8):663-5.
1985: Ulf-Hakan Stenman; H Alfthan; Markku Seppala
New methods revolutionize assays of polypeptide hormones and proteins.
Acta obstetricia et gynecologica Scandinavica 1985;64(8):627-8.
1985: Markku Seppala; A I Koskimies; A Tenhunen; E M Rutanen; Jari Sjöberg; R Koistinen; M Julkunen; T Wahlström
Pregnancy proteins in seminal plasma, seminal vesicles, preovulatory follicular fluid, and ovary.
Annals of the New York Academy of Sciences 1985;442():212-26.
1985: Robert G Edwards; Markku Seppala; W I Johnston; HOWARD JONES; L Rauramo; K Semm; O Widholm; N Wiqvist
Helsinki statement on human in vitro fertilization.
Annals of the New York Academy of Sciences 1985;442():571-2.
1985: Ulf-Hakan Stenman; H Alfthan; A Koskimies; Markku Seppala; K Pettersson; T Lövgren
Monitoring the LH surge by ultrarapid and highly sensitive immunofluorometric assay.
Annals of the New York Academy of Sciences 1985;442():544-50.
1985: T Wahlström; A I Koskimies; A Tenhunen; E M Rutanen; Hannele Yki-Järvinen; M Julkunen; Jari Sjöberg; Markku Seppala
Pregnancy proteins in the endometrium after follicle aspiration for in vitro fertilization.
Annals of the New York Academy of Sciences 1985;442():402-7.
1985: Markku Seppala; E M Rutanen
[Fetal and placental proteins].
Duodecim; lääketieteellinen aikakauskirja 1985;101(3):323-33.
1985: M J Sinosich; J Dodd; C N Hudson; J R Tyler; Markku Seppala; J G Grudzinskas; Douglas M Saunders
The influence of pergonal on in vitro production of placental protein 5 (PP5) by ovarian tumour cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1985;6(3):233-42.
1985: Jari Sjöberg; T Wahlström; Markku Seppala; E M Rutanen; R Koistinen; A I Koskimies; M J Sinosich; B Teisner; J G Grudzinskas
Seminal plasma levels of PAPP-A in normospermic and oligospermic men and tissue localization of PAPP-A in the male genital tract.
Archives of andrology 1985;14(2-3):253-61.
1985: M J Sinosich; Markku Seppala; D M Saunders; J G Grudzinskas
Pregnancy-associated plasma protein-A and placental protein 5 in human seminal plasma.
Annals of the New York Academy of Sciences 1985;442():287-92.
1984: E M Rutanen; R Koistinen; T Wahlström; H Bohn; Markku Seppala
The content of placental protein 12 in decidua and fetal membranes is greater than in placenta.
British journal of obstetrics and gynaecology 1984;91(12):1240-4.
1984: E M Rutanen; R Koistinen; T Wahlström; Ulf-Hakan Stenman; Markku Seppala
Placental protein 12 (PP12) in menstrual fluid.
British journal of obstetrics and gynaecology 1984;91(10):1025-30.
1984: Hannele Yki-Järvinen; T Wahlström; A Tenhunen; A I Koskimies; Markku Seppala
The occurrence of relaxin in hyperstimulated human preovulatory follicles collected in an in vitro fertilization program.
Journal of in vitro fertilization and embryo transfer : IVF 1984;1(3):180-2.
1984: A I Koskimies; A Tenhunen; P Ylöstalo; S Liukkonen; O Widholm; Markku Seppala
The in vitro fertilization program in Helsinki.
Journal of in vitro fertilization and embryo transfer : IVF 1984;1(3):208-9.
1984: H T Salem; M Menabawey; Markku Seppala; M M Shaaban; T Chard
Human seminal plasma contains a wide range of trophoblast-'specific' proteins.
Placenta 1984;5(5):413-7.
1984: E M Rutanen; Markku Seppala; R Pietilä; H Bohn
Placental protein 12 (PP12): factors affecting levels in late pregnancy.
Placenta 1984;5(3):243-8.
1984: T Wahlström; Markku Seppala
Placental protein 12 (PP12) is induced in the endometrium by progesterone.
Fertility and sterility 1984;41(5):781-4.
1984: E M Rutanen; R Koistinen; T Wahlström; J Sjöberg; Ulf-Hakan Stenman; Markku Seppala
Placental protein 12 (PP12) in the human endometrium: tissue concentration in relation to histology and serum levels of PP12, progesterone and oestradiol.
British journal of obstetrics and gynaecology 1984;91(4):377-81.
1984: P Ylöstalo; P Ammälä; Markku Seppala
Intrauterine haematoma and placental protein 5 in patients with uterine bleeding during pregnancy.
British journal of obstetrics and gynaecology 1984;91(4):353-6.
1984: R L Cooper; Markku Seppala; M Linnoila
Effect of luteinizing hormone-releasing hormone antiserum on sexual behavior in the female rat.
Pharmacology, biochemistry, and behavior 1984;20(4):527-30.
1984: Markku Seppala; T Wahlström; A I Koskimies; A Tenhunen; E M Rutanen; R Koistinen; Ilpo Huhtaniemi; H Bohn; Ulf-Hakan Stenman
Human preovulatory follicular fluid, luteinized cells of hyperstimulated preovulatory follicles, and corpus luteum contain placental protein 12.
The Journal of clinical endocrinology and metabolism 1984;58(3):505-10.
1984: J Sjöberg; T Wahlström; Markku Seppala
Pregnancy-associated plasma protein A in the human endometrium is dependent on the effect of progesterone.
The Journal of clinical endocrinology and metabolism 1984;58(2):359-62.
1984: Markku Seppala; A Tenhunen; A I Koskimies; T Wahlström; R Koistinen; Ulf-Hakan Stenman
Hyperstimulated human preovulatory follicular fluid contains placental protein 5 (PP5).
Fertility and sterility 1984;41(1):62-5.
1984: M Julkunen; T Wahlström; Markku Seppala; R Koistinen; A Koskimies; Ulf-Hakan Stenman; H Bohn
Detection and localization of placental protein 14-like protein in human seminal plasma and in the male genital tract.
Archives of andrology 1984;12 Suppl():59-67.
1984: A Boltenberg; S Furgyik; S Kullander; A Rausing; Markku Seppala; T Wahlström
Growth and function of human placenta and amnion grafted to nude mice. A preliminary communication.
Acta obstetricia et gynecologica Scandinavica 1984;63(7):621-4.
1984: E M Rutanen; T Wahlström; R Koistinen; P Sipponen; H Jalanko; Markku Seppala
Placental protein 12 (PP12) in primary liver cancer and cirrhosis.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1984;5(2):95-102.
1983: Hannele Yki-Järvinen; T Wahlström; Markku Seppala
Immunohistochemical demonstration of relaxin in gynecologic tumors.
Cancer 1983;52(11):2077-80.
1983: Hannele Yki-Järvinen; T Wahlström; Markku Seppala
Immunohistochemical demonstration of relaxin in the genital tract of men.
Journal of reproduction and fertility 1983;69(2):693-5.
1983: T Wahlström; I Huhtaniemi; O Hovatta; Markku Seppala
Localization of luteinizing hormone, follicle-stimulating hormone, prolactin, and their receptors in human and rat testis using immunohistochemistry and radioreceptor assay.
The Journal of clinical endocrinology and metabolism 1983;57(4):825-30.
1983: Ulf-Hakan Stenman; H Alfthan; L Myllynen; Markku Seppala
Ultrarapid and highly sensitive time-resolved fluoroimmunometric assay for chorionic gonadotropin.
Lancet 1983;2(8351):647-9.
1983: Hannele Yki-Järvinen; T Wahlström; Markku Seppala
Immunohistochemical demonstration of relaxin in the genital tract of pregnant and nonpregnant women.
The Journal of clinical endocrinology and metabolism 1983;57(3):451-4.
1983: M Heikinheimo; Markku Seppala
Amniotic fluid human chorionic gonadotropin in late pregnancy: elevated levels in toxemia with intrauterine growth retardation.
American journal of obstetrics and gynecology 1983;146(7):766-8.
1983: H T Salem; M M Shaaban; S A Ghaneimah; Markku Seppala; T Chard
Circulating levels of placental proteins, placental protein 5 (PP5), placental lactogen and Schwangerschafts-protein 1 (SP1), in antepartum eclampsia.
British journal of obstetrics and gynaecology 1983;90(7):618-22.
1983: M L Huhtala; K Kahanpää; Markku Seppala; H Halila; Ulf-Hakan Stenman
Excretion of a tumor-associated trypsin inhibitor (TATI) in urine of patients with gynecological malignancy.
International journal of cancer. Journal international du cancer 1983;31(6):711-4.
1983: M Ryynänen; Markku Seppala; P Kuusela; J Rapola; P Aula; A Seppä; V Jokela; O Castren
Antenatal screening for congenital nephrosis in Finland by maternal serum alpha-fetoprotein.
British journal of obstetrics and gynaecology 1983;90(5):437-42.
1983: Markku Seppala; E M Rutanen; J E Siiteri; T Wahlström; R Koistinen; R Pietilä; H Bohn
Immunologic and biological properties and clinical significance of placental proteins PP5 and PP12.
Annals of the New York Academy of Sciences 1983;417():368-82.
1982: T Wahlström; H Bohn; Markku Seppala
Immunohistochemical demonstration of placental protein 5 (PP5) -like material in the seminal vesicle and the ampullar part of vas deferens.
Life sciences 1982;31(24):2723-5.
1982: E M Rutanen; H Bohn; Markku Seppala
Radioimmunoassay of placental protein 12: levels in amniotic fluid, cord blood, and serum of healthy adults, pregnant women, and patients with trophoblastic disease.
American journal of obstetrics and gynecology 1982;144(4):460-3.
1982: Ulf-Hakan Stenman; M L Huhtala; R Koistinen; Markku Seppala
Immunochemical demonstration of an ovarian cancer-associated urinary peptide.
International journal of cancer. Journal international du cancer 1982;30(1):53-7.
1982: J E Siiteri; R Koistinen; H T Salem; H Bohn; Markku Seppala
Placental protein 5 is related to blood coagulation and fibrinolytic systems.
Life sciences 1982;30(22):1885-91.
1982: M Heikinheimo; P Aula; J Rapola; T Wahlström; H Jalanko; Markku Seppala
Amniotic fluid pregnancy-specific beta 1-glycoprotein (SP1) in Meckel's syndrome: a new test for prenatal diagnosis?
Prenatal diagnosis 1982;2(2):103-8.
1982: Ulf-Hakan Stenman; P Tanner; T Ranta; J Schröder; Markku Seppala
Monoclonal antibodies to chorionic gonadotropin: use in a rapid radioimmunoassay for gynecologic emergencies.
Obstetrics and gynecology 1982;59(3):375-7.
1982: J E Siiteri; R Koistinen; H Bohn; Markku Seppala
Placental protein 5 (PP5)-like immunoreactivity in human urine.
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine 1982;3(5-6):403-7.
1982: O Ylikorkala; Markku Seppala
[The role of the fetus in labor].
Duodecim; lääketieteellinen aikakauskirja 1982;98(9):674-81.
1982: Markku Seppala; E M Rutanen; Ulf-Hakan Stenman; J E Siiteri
Pregnancy-specific beta 1-glycoprotein in complicated early pregnancy and trophoblastic disease.
La Ricerca in clinica e in laboratorio 1982;12(1):251-4.
1982: J N Lee; T Wahlström; Markku Seppala; H T Salem; P C Ouyang; T Chard
Immunohistochemical demonstration of placental protein 5 in trophoblastic tumours.
Placenta 1982;3(1):67-70.
1981: T Ranta; J E Siiteri; R Koistinen; H T Salem; H Bohn; A I Koskimies; Markku Seppala
Human seminal plasma contains a protein that shares physicochemical and immunochemical properties with placental protein 5 from the human placenta.
The Journal of clinical endocrinology and metabolism 1981;53(5):1087-9.
1981: H T Salem; Markku Seppala; T Chard
The effect of thrombin on serum placental protein 5 (PP5): is PP5 the naturally occurring antithrombin III of the human placenta?
Placenta 1981;2(3):205-9.
1981: Markku Seppala
[Technology and humaneness in obstetric and gynecologic care].
Kätilölehti 1981;86(7-8):225-6.
1981: T Wahlström; Ulf-Hakan Stenman; C Lundqvist; P Tanner; J Schröder; Markku Seppala
The use of monoclonal antibodies against human chorionic gonadotropin for immunoperoxidase staining of normal placenta, pituitary gland, and pituitary adenomas.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1981;29(7):864-5.
1981: T Wahlström; Markku Seppala
Immunological evidence for the occurrence of luteinizing hormone-releasing factor and the alpha-subunit of glycoprotein hormones in carcinoid tumors.
The Journal of clinical endocrinology and metabolism 1981;53(1):209-12.
1981: J N Lee; T Wahlström; P C Ouyang; T Y Chen; Markku Seppala
Immunohistochemical evidence for prolactin in trophoblastic tumors.
Gynecologic oncology 1981;11(3):299-303.
1981: O Karjalainen; P Aula; Markku Seppala; A L Hartikainen-Sorri; M Ryynänen
Prenatal diagnosis of the Meckel syndrome.
Obstetrics and gynecology 1981;57(6 Suppl):13S-5S.
1981: O Saksela; T Wahlström; P Lehtovirta; Markku Seppala; A Vaheri
Presence of alpha 2-macroglobulin in normal but not in malignant human syncytiotrophoblasts.
Cancer research 1981;41(6):2507-13.
1981: H T Salem; Jes G Westergaard; P Hindersson; Markku Seppala; T Chard
Placental protein 5 (PP5) in placental abruption.
British journal of obstetrics and gynaecology 1981;88(5):500-3.
1981: T Ranta; T Wahlström; E M Rutanen; Ulf-Hakan Stenman; Markku Seppala
Serum prolactin levels and immunohistochemical localization of prolactin in trophoblastic disease.
Acta pathologica et microbiologica Scandinavica. Section A, Pathology 1981;89(3):235-9.
1981: J E Siiteri; R Koistinen; T Ranta; Ulf-Hakan Stenman; Markku Seppala
Use of a rapid radioimmunoassay for pregnancy-specific beta-1 glycoprotein in gynecologic emergencies: comparison with routine urinary pregnancy test and a rapid radioimmunoassay for human chorionic gonadotropin.
American journal of obstetrics and gynecology 1981;139(8):968-70.
1981: H T Salem; Markku Seppala; T Ranta; H Bohn; T Chard
The effect of protamine on serum levels of placental protein 5 (PP5) in normal and abnormal pregnancy: a possible relation to coagulation abnormalities.
British journal of obstetrics and gynaecology 1981;88(4):367-70.
1981: M Heikinheimo; O Saksela; P Lehtovirta; Markku Seppala; H Bohn
Cultured human syncytiotrophoblasts synthesize pregnancy-specific beta-1-glycoprotein (SP1).
Acta pathologica et microbiologica Scandinavica. Section C, Immunology 1981;89(2):139-44.
1981: H T Salem; J N Lee; Markku Seppala; L Vaara; P Aula; A T Al-Ani; T Chard
Measurement of placental protein 5, placental lactogen and pregnancy-specific beta 1 glycoprotein in mid-trimester as a predictor of outcome of pregnancy.
British journal of obstetrics and gynaecology 1981;88(4):371-4.
1981: P Lehtovirta; T Ranta; Markku Seppala
Elevated prolactin levels in oral contraceptive pill-related hypertension.
Fertility and sterility 1981;35(4):403-5.
1981: T Ranta; E M Rutanen; Markku Seppala; Ulf-Hakan Stenman; K Tontti
[Early pregnancy diagnosis with rapid, specific radioimmunological determination of hCG in serum].
Läkartidningen 1981;78(13):1307-8.
1981: J N Lee; H T Salem; A T Al-Ani; T Chard; S C Huang; P C Ouyang; P Y Wei; Markku Seppala
Circulating concentrations of specific placental proteins (human chorionic gonadotropin, pregnancy-specific beta-1 glycoprotein, and placental protein 5) in untreated gestational trophoblastic tumors.
American journal of obstetrics and gynecology 1981;139(6):702-4.
1981: J N Lee; Markku Seppala; T Chard
Characterization of placental luteinizing hormone-releasing factor-like material.
Acta endocrinologica 1981;96(3):394-7.
1981: J N Lee; H T Salem; S c Huang; P C Ouyang; Markku Seppala; T Chard
Placental protein 5 (PP5) in severe pre-eclampsia and eclampsia.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1981;19(1):65-7.
1981: Markku Seppala; T Ranta; E M Rutanen; U H Stenman; K Tontti; T Chard
Improved diagnosis of pregnancy-related gynaecological emergencies by rapid human chorionic gonadotrophin beta-subunit assay.
British journal of obstetrics and gynaecology 1981;88(2):138-40.
1981: T Ranta; E M Rutanen; U H Stenman; H Weitzel; Markku Seppala
[Improved diagnosis of pregnancy-associated gynaecological emergencies via rapid beta-HCG test (author's transl)].
Geburtshilfe und Frauenheilkunde 1981;41(2):91-2.
1981: R Koistinen; M Heikinheimo; E M Rutanen; U H Stenman; J N Lee; Markku Seppala
Concanavalin A binding of pregnancy-specific beta-1-glycoprotein in normal pregnancy and trophoblastic disease.
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine 1981;2(3):179-82.
1981: Markku Seppala
[Oncofetal proteins in diagnosis of fetal malformations and cancer].
Duodecim; lääketieteellinen aikakauskirja 1981;97(10):652-62.
1981: T Wahlström; B Teisner; J N Lee; J G Grudzinskas; Markku Seppala; J Folkersen
Placenta-associated plasma protein-A (PAPP-A, SP4) in trophoblastic tumours.
Acta pathologica et microbiologica Scandinavica. Section A, Pathology 1981;89(1):65-6.
1980: M Heikinheimo; T Wahlström; P Aula; I Virtanen; Markku Seppala
Pregnancy-specific beta-1-glycoprotein (SP1) in cultured amniotic fluid cells.
The Journal of clinical endocrinology and metabolism 1980;51(6):1432-6.
1980: P K Kinnunen; H A Unnérus; T Ranta; C Ehnholm; E A Nikkilä; Markku Seppala
Activities of post-heparin plasma lipoprotein lipase and hepatic lipase during pregnancy and lactation.
European journal of clinical investigation 1980;10(6):469-74.
1980: H T Salem; B C Obiekwe; A T Al-Ani; Markku Seppala; T Chard
Molecular heterogeneity of placental protein 5 (PP5) in late pregnancy serum and plasma: evidence for a heparin-PP5 polymer.
Clinica chimica acta; international journal of clinical chemistry 1980;107(3):211-5.
1980: H Bohm; J G Grudzinskas; S Rosen; Markku Seppala; Y S Tatarinov; T Chard; A Klopper; P Schultz-Larsen; P Sizaret; B Teisner
Reference preparation for assay of some pregnancy and cancer associated proteins.
Lancet 1980;2(8198):796.
1980: Markku Seppala; T Wahlström
Identification of luteinizing hormone-releasing factor and alpha subunit of glycoprotein hormones in ductal carcinoma of the mammary gland.
International journal of cancer. Journal international du cancer 1980;26(3):267-8.
1980: T Ranta; P Lehtovirta; U H Stenman; T Laatikainen; Markku Seppala
Acute changes in serum prolactin concentration have no effect on the secretion of progesterone, estradiol, or chorionic gonadotropin during early pregnancy.
The Journal of clinical endocrinology and metabolism 1980;51(3):544-7.
1980: Markku Seppala; T Wahlström
Identification of luteinizing hormone-releasing factor and alpha-subunit of glycoprotein hormones in human pancreatic islets.
Life sciences 1980;27(5):395-7.
1980: M Heikinheimo; Markku Seppala; D J Brock
Pregnancy specific beta 1-glycoprotein and human chorionic gonadotrophin levels n amniotic fluid and maternal serum in the first half of pregnancy.
Oncodevelopmental biology and medicine : the journal of the International Society for Oncodevelopmental Biology and Medicine 1980;1(1):71-6.
1980: A Kauppila; P Rantakylä; I Huhtaniemi; O Ylikorkala; Markku Seppala
Trophoblastic markers in the differential diagnosis of ectopic pregnancy.
Obstetrics and gynecology 1980;55(5):560-4.
1980: Markku Seppala; T Wahlström; P Lehtovirta; J N Lee; J Leppälouto
Immunohistochemical demonstration of luteinizing hormone-releasing factor-like material in human syncytiotrophoblast and trophoblastic tumours.
Clinical endocrinology 1980;12(5):441-51.
1980: D J Brock; C Hayward; Markku Seppala
Distinguishing neural tube defects and congenital nephrosis by amniotic fluid assay.
Lancet 1980;1(8171):773.
1980: T Ranta; U H Stenman; H A Unnérus; J Rossi; Markku Seppala
Maternal plasma prolactin levels in preeclampsia.
Obstetrics and gynecology 1980;55(4):428-30.
1980: P Jouppila; Markku Seppala; T Chard
Pregnancy-specific beta-glycoprotein in complications of early pregnancy.
Lancet 1980;1(8170):667-8.
1980: T Wahlström; Markku Seppala
Tissue CEA test in endocervical and endometrial adenocarcinoma.
Lancet 1980;1(8168 Pt 1):597.
1980: O Ylikorkala; M Siljander; I Huhtaniemi; A Kauppila; Markku Seppala
Trophoblastic markers in women using intrauterine contraception.
Obstetrics and gynecology 1980;55(3):329-32.
1980: Markku Seppala; K Tontti; T Ranta; U H Stenman; T Chard
Use of a rapid hCG-beta-subunit radioimmunoassay in acute gynaecological emergencies.
Lancet 1980;1(8161):165-6.
1980: Markku Seppala; P Venesmaa; E M Rutanen
Pregnancy-specific beta-1 glycoprotein in ectopic pregnancy.
American journal of obstetrics and gynecology 1980;136(2):189-93.
1980: Markku Seppala; K Tontti; T Ranta; U H Stenman
[Rapid and specific determination of serum HCG in gynecological emergencies].
Duodecim; lääketieteellinen aikakauskirja 1980;96(9):667-72.
1980: Markku Seppala
[Hyperprolactinemia and pregnancy].
Duodecim; lääketieteellinen aikakauskirja 1980;96(2):163-7.
1980: T Wahlström; J Lindgren; M Korhonen; Markku Seppala
[Differential diagnosis of adenocarcinoma of the uterus and cervix using CEA immunohistochemical staining].
Duodecim; lääketieteellinen aikakauskirja 1980;96(11):804-7.
1980: E M Rutanen; Markku Seppala
Pregnancy-specific beta-1-glycoprotein in trophoblastic disease.
The Journal of clinical endocrinology and metabolism 1980;50(1):57-61.
1980: RS Ikonen; J Lindgren; E Niemi; A E Sorto; Markku Seppala; E Ruoslahti
Alpha fetoprotein levels in neonatal hyperbilirubinaemia.
Acta paediatrica Scandinavica 1980;69(1):59-63.
1979: T Wahlström; Markku Seppala
Luteinizing hormone-releasing factor-like immunoreactivity in islet cells and insulomas of the human pancreas.
International journal of cancer. Journal international du cancer 1979;24(6):744-8.
1979: J Lindgren; P Sipponen; K Seppälä; S Tarpila; S Nordling; T Wahlström; Markku Seppala
Carcinoembryonic antigen in endoscopic brush specimens from benign and malignant gastric lesions.
British journal of cancer 1979;40(6):848-55.
1979: T Wahlström; J Lindgren; M Korhonen; Markku Seppala
Distinction between endocervical and endometrial adenocarcinoma with immunoperoxidase staining of carcinoembryonic antigen in routine histological tissue specimens.
Lancet 1979;2(8153):1159-60.
1979: Markku Seppala; L Rönnberg; P Ylöstalo; P Jouppila
Early detection of implantation by pregnancy-specific beta 1-glycoprotein secretion in an infertile woman treated by artificial insemination and human chorionic gonadotropin.
Fertility and sterility 1979;32(5):608-9.
1979: Markku Seppala; T Wahlström; J Leppäluoto
Luteinizing hormone-releasing factor (LRF)-like immunoreactivity in rat pancreatic islet cells.
Life sciences 1979;25(17):1489-96.
1979: O Hovatta; A I Koskimies; T Ranta; U H Stenman; Markku Seppala
Bromocriptine treatment of oligospermia: a double blind study.
Clinical endocrinology 1979;11(4):377-82.
1979: E Ruoslahti; A Pekkala; D E Comings; Markku Seppala
Determination of subfractions of amniotic fluid alpha-fetoprotein in diagnosing spina bifida and congenital nephrosis.
British medical journal 1979;2(6193):768-9.
1979: O Ylikorkala; I Huhtaniemi; R Tuimala; Markku Seppala
Subnormal postconceptional levels of prolactin do not interfere with the early events of human pregnancy.
Fertility and sterility 1979;32(3):286-8.
1979: P Aula; O Karjalainen; K Teramo; L Vaara; Markku Seppala
Safety and accuracy of midtrimester amniocentesis for prenatal diagnosis of genetic disorders.
Annals of clinical research 1979;11(4):156-63.
1979: Markku Seppala; T Wahlström; H Bohn
Circulating levels and tissue localization of placental protein five (PP5) in pregnancy and trophoblastic disease: absence of PP5 expression in the malignant trophoblast.
International journal of cancer. Journal international du cancer 1979;24(1):6-10.
1979: J Juntunen; M Kaste; M Iivanainen; T Ranta; Markku Seppala
Bromocriptine treatment of spasmodic torticollis. A double-blind crossover study.
Archives of neurology 1979;36(7):449-50.
1979: E Ruoslahti; T Estes; Markku Seppala
Binding of bilirubin by bovine and human alpha-fetoprotein.
Biochimica et biophysica acta 1979;578(2):511-9.
1979: T Ranta; H A Unnérus; J Rossi; Markku Seppala
Elevated plasma prolactin concentration in cholestasis of pregnancy.
American journal of obstetrics and gynecology 1979;134(1):1-3.
1979: J Lindgren; T Wahlström; Markku Seppala
Tissue CEA in premalignant epithelial lesions and epidermoid carcinoma of the uterine cervix: prognostic significance.
International journal of cancer. Journal international du cancer 1979;23(4):448-53.
1979: T Ranta; P Lehtovirta; U H Stenman; Markku Seppala
Serum prolactin and progesterone concentrations in ovulatory infertility.
Journal of endocrinological investigation 1979;2(1):71-3.
1979: Markku Seppala; E M Rutanen
[Pregnancy specific beta-1-glycoprotein].
Duodecim; lääketieteellinen aikakauskirja 1979;95(22):1490-8.
1979: E Ruoslahti; Markku Seppala
alpha-Fetoprotein in cancer and fetal development.
Advances in cancer research 1979;29():275-346.
1979: P Lehtovirta; P Arjomaa; T Ranta; T Laatikainen; E Hirvonen; Markku Seppala
Prolactin levels and bromocriptine treatment of short luteal phase.
International journal of fertility 1979;24(1):57-60.
1978: Markku Seppala; E M Rutanen; H Jalanko; P Lehtovirta; U H Stenman; E Engvall
Pregnancy-specific beta 1-glycoprotein and chorionic gonadotropin-like immunoreactivity during the latter half of the cycle in women using intrauterine contraception.
The Journal of clinical endocrinology and metabolism 1978;47(6):1216-9.
1978: E Ruoslahti; E Engvall; A Pekkala; Markku Seppala
Developmental changes in carbohydrate moiety of human alpha-fetoprotein.
International journal of cancer. Journal international du cancer 1978;22(5):515-20.
1978: M Ryynänen; O Castren; J Rapola; P Aula; Markku Seppala
Prenatal screening for congenital nephrosis.
Lancet 1978;2(8097):991.
1978: P Aula; J Rapola; O Karjalainen; J Lindgren; A L Hartikainen; Markku Seppala
Prenatal diagnosis of congenital nephrosis in 23 high-risk families.
American journal of diseases of children (1960) 1978;132(10):984-7.
1978: M Heikinheimo; H A Unnérus; T Ranta; H Jalanko; Markku Seppala
Pregnancy-specific beta-1-glycoprotein levels in cholestasis of pregnancy.
Obstetrics and gynecology 1978;52(3):276-8.
1978: M Iivanainen; M Kaste; J Juntunen; S Kruus; T Ranta; Markku Seppala
Effect of bromocriptine on dystonic-athetoid dyskinesias in mentally retarded patients.
Journal of mental deficiency research 1978;22(3):193-6.
1978: M Mandelin; E M Rutanen; M Heikinheimo; H Jalanko; Markku Seppala
Pregnancy-specific beta-1-glycoprotein and chorionic gonadotropin levels after first-trimester abortions.
Obstetrics and gynecology 1978;52(3):314-7.
1978: E M Rutanen; J Lindgren; P Sipponen; U P Stenman; E Saksela; Markku Seppala
Carcinoembryonic antigen in malignant and nonmalignant gynecologic tumors: circulating levels and tissue localization.
Cancer 1978;42(2):581-90.
1978: J Halme; M Ikonen; E M Rutanen; Markku Seppala
Gonadotropin receptors of human corpus luteum during menstrual cycle and pregnancy.
American journal of obstetrics and gynecology 1978;131(7):728-34.
1978: P Kajanoja; T Ranta; Markku Seppala
Effect of prostaglandin F2alpha on ovarian and pituitary function in the mid-luteal phase.
Prostaglandins 1978;16(2):327-32.
1978: Markku Seppala; P Lehtovirta; E M Rutanen
Detection of chorionic gonadotrophin like activity in infertile cycles with a short luteal phase.
Acta endocrinologica 1978;88(1):164-8.
1978: P Lehtovirta; T Ranta; Markku Seppala
Pyridoxine treatment of galactorrhoea-amenorrhoea syndromes.
Acta endocrinologica 1978;87(4):682-6.
1978: Markku Seppala
[Prolactin and its importance in the reproductive system].
Akusherstvo i ginekologii͡a 1978;(4):5-8.
1978: Markku Seppala; E M Rutanen; M Heikinheimo; H Jalanko; E Engvall
Detection of trophoblastic tumour activity by pregnancy-specific beta-1-glycoprotein.
International journal of cancer. Journal international du cancer 1978;21(3):265-7.
1978: E M Rutanen; Markku Seppala
The hCG-beta subunit radioimmunoassay in nontrophoblastic gynecologic tumors.
Cancer 1978;41(2):692-6.
1978: Markku Seppala
Prolactin and female reproduction.
Annals of clinical research 1978;10(3):164-70.
1978: A I Koskimies; O Hovatta; T Ranta; Markku Seppala
Serum and seminal plasma prolactin levels in oligospermia.
International journal of fertility 1978;23(1):76-8.
1977: P Aula; O Karjalainen; J Rapola; J Lindgren; Markku Seppala
Prenatal diagnosis of the Meckel syndrome.
American journal of obstetrics and gynecology 1977;129(6):700-2.
1977: Markku Seppala; P Lehtovirta; T Ranta
Discordant patterns of hyperprolactinaemia and galactorrhoea in secondary amenorrhoea.
Acta endocrinologica 1977;86(3):457-63.
1977: Markku Seppala
Immunologic detection of alpha fetoprotein as a marker of fetal pathology.
Clinical obstetrics and gynecology 1977;20(3):737-57.
1977: E Hirvonen; Markku Seppala; S L Karonen; H Adlercreutz
Luteinizing hormone responses to luteinizing hormone releasing hormone, and growth hormone and cortisol responses to insulin induced hypoglycaemia in functional secondary amenorrhoea.
Acta endocrinologica 1977;84(2):225-36.
1977: Markku Seppala
[Diagnosis and treatment of uterine neoplasms].
Duodecim; lääketieteellinen aikakauskirja 1977;93(6):352-5.
1976: L Garoff; Markku Seppala
Toxemia of pregnancy: assessment of fetal distress by urinary estriol and circulating human placental lactogen and alpha-fetoprotein levels.
American journal of obstetrics and gynecology 1976;126(8):1027-33.
1976: Markku Seppala; E M Rutanen; T Ranta; I Aho; U Nieminen; H A Unnérus; E Saksela
Choriocarcinoma: expression of tumor- and trophoblast-associated antigens in patients with low chorionic gonadotropin excretion.
Cancer 1976;38(5):2065-70.
1976: M Vuento; E Engvall; Markku Seppala; E Ruoslahti
Isolation from human gastric juice of an antigen closely related to the carcinoembryonic antigen.
International journal of cancer. Journal international du cancer 1976;18(2):156-60.
1976: Markku Seppala; H A Unnérus; E Hirvonen; T Ranta
Bromocriptine increases plasma estradiol-17 beta concentration in amenorrhea patients with normal serum prolactin.
The Journal of clinical endocrinology and metabolism 1976;43(2):474-7.
1976: Markku Seppala; J Rapola; N P Huttunen; P Aula; O Karjalainen; E Ruoslahti
Congenital nephrotic syndrome: prenatal diagnosis and genetic counselling by estimation of aminotic-fluid and maternal serum alpha-fetoprotein.
Lancet 1976;2(7977):123-5.
1976: Markku Seppala; E Hirvonen; H A Unnérus; T Ranta; T Laatikainen
Prolactin and testosterone: independent circulating levels in hyperprolactinemic and normoprolactinemic amenorrhea. The effect of prolactin suppression by bromocriptine.
The Journal of clinical endocrinology and metabolism 1976;43(1):198-200.
1976: E Hirvonen; T Ranta; Markku Seppala
Prolactin and thyrotropin responses to thyrotropin-releasing hormone in patients with secondary amenorrhea: the effect of bromocriptine.
The Journal of clinical endocrinology and metabolism 1976;42(6):1024-30.
1976: Markku Seppala; E Hirvonen; T Ranta
Bromocriptine treatment of secondary amenorrhoea.
Lancet 1976;1(7970):1154-6.
1976: Markku Seppala; O Karjalainen; J Rapola; J Lindgren
Letter: Maternal alpha-fetoprotein and fetal exomphalos.
Lancet 1976;1(7954):303-4.
1976: Markku Seppala; T Ranta; E Hirvonen
Hyperprolactinaemia and luteal insufficiency.
Lancet 1976;1(7953):229-30.
1976: J Leppäluoto; O Mäkelä; Markku Seppala
[Biologically active peptides].
Duodecim; lääketieteellinen aikakauskirja 1976;92(22):1261-4.
1976: Markku Seppala; E Ruoslahti
Alpha-fetoprotein.
Contributions to gynecology and obstetrics 1976;2():143-86.
1976: Markku Seppala
The use of alpha fetoprotein in prenatal diagnosis.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1976;14(4):308-13.
1975: Markku Seppala; E Hirvonen
Raised serum prolactin levels associated with hirsutism and amenorrhoea.
British medical journal 1975;4(5989):144-5.
1975: Markku Seppala
Fetal pathophysiology of human alpha-fetoprotein.
Annals of the New York Academy of Sciences 1975;259():59-73.
1975: Markku Seppala; E Hibroven; T Ranta; P Virkkunen; J Leppăluoto
Raised serum prolactin levels in amenorrhoea.
British medical journal 1975;2(5966):305-6.
1975: Markku Seppala; H Pihko; E Ruoslahti
Carcinoembryonic antigen and alpha fetoprotein in malignant tumors of the female genital tract.
Cancer 1975;35(5):1377-81.
1975: J Rapola; P Aula; N Huttunen; Markku Seppala
Letter: Antenatal diagnosis of congenital nephrosis.
Lancet 1975;1(7913):981.
1975: L Garoff; Markku Seppala
Prediction of fetal outcome in threatened abortion by maternal serum placental lactogen and alpha fetoprotein.
American journal of obstetrics and gynecology 1975;121(2):257-61.
1975: Markku Seppala
[Prolactin].
Duodecim; lääketieteellinen aikakauskirja 1975;91(24):1525-35.
1975: P Aula; O Karjalainen; Markku Seppala
[Amniotic fluid analysis in the early diagnosis of fetal abnormalities].
Duodecim; lääketieteellinen aikakauskirja 1975;91(18):1064-76.
1975: Markku Seppala; I Aho
Physiological role of meconium during delivery.
Acta obstetricia et gynecologica Scandinavica 1975;54(3):209-11.
1974: P Kajanoja; G Junger; Markku Seppala; O Karjalainen; O Widholm
Prostaglandin induction of 424 midtrimester abortions.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 1974;12(6):198-203.
1974: P Virkkunen; H Lybeck; J Partanen; T Ranta; J Leppäluoto; Markku Seppala
Plasma disapperance of injected synthetic LRH in man as measured by bioassay and radioimmunoassay.
The Journal of clinical endocrinology and metabolism 1974;39(4):702-5.
1974: Markku Seppala; E Laes; M Harvo-Noponen
Elevated amniotic alpha-fetoprotein congenital oesophageal atresia.
The Journal of obstetrics and gynaecology of the British Commonwealth 1974;81(10):827-8.
1974: Markku Seppala
Alpha-fetoprotein in the management of high-risk pregnancies.
Clinics in perinatology 1974;1(2):293-300.
1974: E Ruoslahti; M Salaspuro; H Pihko; L Andersson; Markku Seppala
Serum alpha-fetoprotein: diagnostic significance in liver disease.
British medical journal 1974;2(5918):527-9.
1974: Markku Seppala; H A Unnérus
Elevated amniotic fluid alpha fetoprotein in fetal hydrocephaly.
American journal of obstetrics and gynecology 1974;119(2):270-2.
1974: R Harris; R F Jennison; A J Barson; K M Laurence; E Ruoslahti; Markku Seppala
Comparison of amniotic-fluid and maternal serum alpha-fetoprotein levels in the early antenatal diagnosis of spina bifida and anencephaly.
Lancet 1974;1(7855):428-9.
1974: P Kajanoja; G Jungner; O Widholm; O Karjalainen; Markku Seppala
Rupture of the cervix in prostaglandin abortions.
The Journal of obstetrics and gynaecology of the British Commonwealth 1974;81(3):242-4.
1974: Markku Seppala; A Vaheri
Natural rubella infection of the female genital tract.
Lancet 1974;1(7846):46-7.
1974: P Kajanoja; G Jungner; Markku Seppala; O Karjalainen; O Widholm
Prostaglandin induction of midtrimester abortions: three years' experience of 626 cases.
Acta obstetricia et gynecologica Scandinavica. Supplement 1974;37():51-6.
1974: E Ruoslahti; H Pihko; A Vaheri; Markku Seppala; M Virolainen; A Konttinen
Alpha fetoprotein: structure and expression in man and inbred mouse strains under normal conditions and liver injury.
Johns Hopkins medical journal. Supplement 1974;3():249-55.
1974: E Ruoslahti; H Pihko; Markku Seppala
Alpha-fetoprotein: immunochemical purification and chemical properties. Expression in normal state and in malignant and non-malignant liver disease.
Transplantation reviews 1974;20(0):38-60.
1973: Markku Seppala; E Ruoslahti
Alpha-fetoprotein in Rh-immunized pregnancies.
Obstetrics and gynecology 1973;42(5):701-6.
1973: K M Laurence; A C Turnbull; R Harris; R F Jennison; E Ruoslahti; Markku Seppala
Letter: Antenatal diagnosis of spina bifida.
Lancet 1973;2(7833):860.
1973: Markku Seppala
Increased alpha fetoprotein in amniotic fluid associated with a congenital esophageal atresia of the fetus.
Obstetrics and gynecology 1973;42(4):613-4.
1973: L Garoff; Markku Seppala
Alpha fetoprotein and human placental lactogen levels in maternal serum in multiple pregnancies.
The Journal of obstetrics and gynaecology of the British Commonwealth 1973;80(8):695-700.
1973: S Saarikoski; Markku Seppala
Immunosuppression during pregnancy: transmission of azathioprine and its metabolites from the mother to the fetus.
American journal of obstetrics and gynecology 1973;115(8):1100-6.
1973: Markku Seppala; E Ruoslahti
Alpha-fetoprotein in antenatal diagnosis.
Lancet 1973;1(7795):155.
1973: Markku Seppala; O V Renkonen; P Vara
Extra-amniotic prostaglandin-oxytocin abortion: comparison with the intra-amniotic method.
Prostaglandins 1973;3(1):17-28.
1973: Markku Seppala
Alpha fetoprotein levels in women taking oral contraceptives.
International journal of fertility 1973;18(4):206-8.
1973: Markku Seppala; E Ruoslahti
Alpha fetoprotein: Physiology and pathology during pregnancy and application to antenatal diagnosis.
Journal of perinatal medicine 1973;1(2):104-13.
1973: Markku Seppala
[Alpha 1-fetoprotein in obstetrics].
Duodecim; lääketieteellinen aikakauskirja 1973;89(20):1353-4.
1973: E Ruoslahti; Markku Seppala; J A Räsänen; P Vuopio; T Helske
Alpha-fetoprotein and hepatitis B antigen in acute hepatitis and primary cancer of the liver.
Scandinavian journal of gastroenterology 1973;8(3):197-202.
1973: Markku Seppala; E Ruoslahti
Alpha fetoprotein in maternal serum: a new marker for detection of fetal distress and intrauterine death.
American journal of obstetrics and gynecology 1973;115(1):48-52.
1972: Markku Seppala; E Ruoslahti
Alpha-fetoprotein in abortion.
British medical journal 1972;4(5843):769-71.
1972: Markku Seppala; I Aho; A Tissari; E Ruoslahti
Radioimmunoassay of oxytocin in amniotic fluid, fetal urine, and meconium during late pregnancy and delivery.
American journal of obstetrics and gynecology 1972;114(6):788-95.
1972: Markku Seppala; K D Bagshawe; E Ruoslahti
Radioimmunoassay of alpha-fetoprotein: a contribution to the diagnosis of choriocarcinoma and hydatidiform mole.
International journal of cancer. Journal international du cancer 1972;10(3):478-81.
1972: Markku Seppala; E Ruoslahti
Alpha fetoprotein in amniotic fluid: an index of gestational age.
American journal of obstetrics and gynecology 1972;114(5):595-8.
1972: Markku Seppala; P Kajanoja; O Widholm; P Vara
Prostaglandin-oxytocin abortion: a clinical trial of intra-amniotic prostaglandin F2alpha in combination with intravenous oxytocin.
Prostaglandins 1972;2(4):311-9.
1972: E Ruoslahti; Markku Seppala; P Vuopio; E Saksela; P Peltokallio
[Radioimmunoassay of alpha-fetoprotein in primary and secondary cancer of the liver].
Journal of the National Cancer Institute 1972;49(3):623-30.
1972: E Ruoslahti; Markku Seppala
Normal and increased alpha-fetoprotein in neoplastic and non-neoplastic liver disease.
Lancet 1972;2(7771):278-9.
1972: Markku Seppala; I Aho; O Widholm; E Ruoslahti
Alpha fetoprotein in uterine hemorrhage during pregnancy and delivery.
American journal of obstetrics and gynecology 1972;113(3):323-8.
1972: A Vaheri; T Vesikari; N Oker-Blom; Markku Seppala; P D Parkman; J Veronelli; F C Robbins
Isolation of attenuated rubella-vaccine virus from human products of conception and uterine cervix.
The New England journal of medicine 1972;286(20):1071-4.
1972: Markku Seppala; P Vara
Prostaglandin-oxytocin enhancement.
British medical journal 1972;1(5802):747.
1972: Markku Seppala; E Ruoslahti
Alpha-fetoprotein in normal and pregnancy sera.
Lancet 1972;1(7746):375-6.
1972: E Ruoslahti; Markku Seppala
-Foetoprotein in normal human serum.
Nature 1972;235(5334):161-2.
1972: Markku Seppala; E Ruoslahti
Radioimmunoassay of maternal serum alpha fetoprotein during pregnancy and delivery.
American journal of obstetrics and gynecology 1972;112(2):208-12.
1972: Markku Seppala
[Prostaglandins and abortion].
Duodecim; lääketieteellinen aikakauskirja 1972;88(17):1029-31.
1972: E Ruoslahti; Markku Seppala
[Alpha-fetoprotein--a carcinoembryonal antigen].
Duodecim; lääketieteellinen aikakauskirja 1972;88(17):1033-43.
1971: E Ruoslahti; Markku Seppala
Studies of carcino-fetal proteins. 3. Development of a radioimmunoassay for -fetoprotein. Demonstration of -fetoprotein in serum of healthy human adults.
International journal of cancer. Journal international du cancer 1971;8(3):374-83.
1971: E Ruoslahti; Markku Seppala; H Pihko; P Vuopio
Studies of carcino-fetal proteins. II. Biochemical comparison of -fetoprotein from human fetuses and patients with hepatocellular cancer.
International journal of cancer. Journal international du cancer 1971;8(2):283-8.
1971: F Fuchs; Niels C R Räihä; Markku Seppala
Ethanol administration in premature labour.
Lancet 1971;2(7719):312-3.
1971: Markku Seppala; Niels C R Räihä; V Tamminen
Ethanol elimination in a mother and her premature twins.
Lancet 1971;1(7710):1188-9.
1971: E Ruoslahti; Markku Seppala
Studies of carcino-fetal proteins: physical and chemical properties of human alpha-fetoprotein.
International journal of cancer. Journal international du cancer 1971;7(2):218-25.
1971: Markku Seppala; P Vara
Standardization of the results of Shirodkar's operation.
Acta obstetricia et gynecologica Scandinavica. Supplement 1971;9():Suppl 9:66.
1971: Markku Seppala; E Saksela
Placental haemangiomatosis and severe maternal eclampsia.
Acta obstetricia et gynecologica Scandinavica 1971;50(4):397-9.
1971: Markku Seppala; R Vihko
[Lactation and its disturbances].
Duodecim; lääketieteellinen aikakauskirja 1971;87(6):478-84.
1970: E Ikonen; E Merikallio; K Osterlund; Markku Seppala
Mitral-valve prosthesis, warfarin anticoagulation, and pregnancy.
Lancet 1970;2(7685):1252.
1970: Markku Seppala; M Tolonen
Histocompatibility and human placentation.
Nature 1970;225(5236):950-1.
1970: Markku Seppala; P Vara
Cervical cerclage in the treatment of incompetent cervix. A retrospective analysis of the indications and results of 164 operations.
Acta obstetricia et gynecologica Scandinavica 1970;49(4):343-6.
1970: Markku Seppala
[Antibiotics during pregnancy and puerperium].
Duodecim; lääketieteellinen aikakauskirja 1970;86(4):237-41.
1970: Markku Seppala; E Ruoslahti
Serum concentration of human placental lactogenic hormone (HPL) in pregnancy complications.
Acta obstetricia et gynecologica Scandinavica 1970;49(2):143-7.
1970: Markku Seppala; I J Seppälä
Immunochemical determination of serum transferrin in patients with anaemia of pregnancy.
Annales chirurgiae et gynaecologiae Fenniae 1970;59(2):76-9.
1970: Markku Seppala; E Ruoslahti; S Soikkeli; P Tukiainen
Effect of cyclophosphamide on serum immunoglobulin level in patients with tumours of the genital tract.
Annales medicinae experimentalis et biologiae Fenniae 1970;48(3):131-4.
1969: A Vaheri; T Vesikari; N Oker-Blom; Markku Seppala; J Veronelli; F C Robbins; P D Parkman
Transmission of attenuated rubella vaccines to the human fetus. A preliminary report.
American journal of diseases of children (1960) 1969;118(2):243-6.
1969: S Kaivola; Markku Seppala; I J Seppälä
The effect of human serum on the activity of human pituitary (HPG) and menopausal (HMG) gonadotrophins in bioassay.
Annales medicinae experimentalis et biologiae Fenniae 1969;47(1):43-7.
1969: Markku Seppala; I J Seppälä
Studies of a foeto-specific protein in rabbits. Absence of its relation to the human alpha-foetoprotein.
Annales chirurgiae et gynaecologiae Fenniae 1969;58(1):76-9.
1969: A Tiilikainen; E Ruoslahti; Markku Seppala; L Mårtensson; E Van Loghem
Low frequency of genetic factors (gm(s) and Di(a) in Finland.
Human heredity 1969;19(2):180-4.
1968: E Ruoslahti; I J Seppälä; K Simons; Markku Seppala
Identity of transferrin DChi from the Chinese and from the Finns.
Nature 1968;220(5166):480-1.
1968: M Harvo-Noponen; Markku Seppala
Double blind study of oral chymotrypsin in patients with episiotomy.
Annales chirurgiae et gynaecologiae Fenniae 1968;57(4):444-6.
1968: E Linder; Markku Seppala
Localization of alpha-foetoprotein in the human foetus and placenta.
Acta pathologica et microbiologica Scandinavica 1968;73(4):565-71.
1967: Markku Seppala; E Ruoslahti; I J Seppälä
Transferrin system in paternity cases. An immunological verification test for heterozygosity.
Annales medicinae experimentalis et biologiae Fenniae 1967;45(1):14-5.
1967: C Ehnholm; Markku Seppala; T Tallberg; O Widholm
Immunological studies in human placental lactogen hormone in chorionepithelioma and hydatiform mole.
Annales medicinae experimentalis et biologiae Fenniae 1967;45(3):318-9.
1967: Markku Seppala; T Tallberg; C Ehnholm
Studies on embryo-specific proteins. Physiological characteristics of embryo-specific alpha-globulin.
Annales medicinae experimentalis et biologiae Fenniae 1967;45(1):16-9.
1966: E Ruoslahti; T Tallberg; Markku Seppala
Origin of proteins in amniotic fluid.
Nature 1966;212(5064):841.
1966: Markku Seppala; E Ruoslahti; T Tallberg
Genetical evidence for maternal origin of amniotic fluid proteins.
Annales medicinae experimentalis et biologiae Fenniae 1966;44(1):6-7.
1965: Markku Seppala
Distribution of serum transferrin groups in Finland and their inheritance.
Annales medicinae experimentalis et biologiae Fenniae 1965;43():Suppl 4:1-40.
1962: K O RENKONEN; Markku Seppala
The sex of the immunizing Rhpositive child.
Annales medicinae experimentalis et biologiae Fenniae 1962;40():108-9.