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Christian Felder

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Todd M Suter; Amy K Chesterfield; Chun Bao; John M Schaus; Joseph H Krushinski; Michael A Statnick; Christian Felder
Pharmacological characterization of the cannabinoid CB₁ receptor PET ligand ortholog, [³H]MePPEP.
Vindhya Nawaratne; Katie Leach; Christian Felder; Patrick M Sexton; Arthur Christopoulos
Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.
Katie Leach; Richard E Loiacono; Christian Felder; David L McKinzie; Adrian Mogg; David B Shaw; Patrick M Sexton; Arthur Christopoulos
Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.

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2010: Todd M Suter; Amy K Chesterfield; Chun Bao; John M Schaus; Joseph H Krushinski; Michael A Statnick; Christian Felder
Pharmacological characterization of the cannabinoid CB₁ receptor PET ligand ortholog, [³H]MePPEP.
European journal of pharmacology 2010;649(1-3):44-50.
2010: Vindhya Nawaratne; Katie Leach; Christian Felder; Patrick M Sexton; Arthur Christopoulos
Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.
The Journal of biological chemistry 2010;285(25):19012-21.
2010: Katie Leach; Richard E Loiacono; Christian Felder; David L McKinzie; Adrian Mogg; David B Shaw; Patrick M Sexton; Arthur Christopoulos
Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(4):855-69.
2010: Garth E Terry; Jussi Hirvonen; Jeih-San Liow; Sami S Zoghbi; Robert L Gladding; Johannes T Tauscher; John M Schaus; Lee A Phebus; Christian Felder; Cheryl L Morse; Sean R Donohue; Victor W Pike; Christer Halldin; Robert B Innis
Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(1):112-20.
2009: Garth E Terry; Jeih-San Liow; Sami S Zoghbi; Jussi Hirvonen; Amanda G Farris; Alicja Lerner; Johannes T Tauscher; John M Schaus; Lee A Phebus; Christian Felder; Cheryl L Morse; Jinsoo S Hong; Victor W Pike; Christer Halldin; Robert B Innis
Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand.
NeuroImage 2009;48(2):362-70.
2008: Vindhya Nawaratne; Katie Leach; Nur Suratman; Richard E Loiacono; Christian Felder; Blaine N Armbruster; Bryan L Roth; Patrick M Sexton; Arthur Christopoulos
New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug).
Molecular pharmacology 2008;74(4):1119-31.
2008: Sean R Donohue; Joseph H Krushinski; Victor W Pike; Eyassu Chernet; Lee A Phebus; Amy K Chesterfield; Christian Felder; Christer Halldin; John M Schaus
Synthesis, ex vivo evaluation, and radiolabeling of potent 1,5-diphenylpyrrolidin-2-one cannabinoid subtype-1 receptor ligands as candidates for in vivo imaging.
Journal of medicinal chemistry 2008;51(18):5833-42.
2008: W Y Chan; David L McKinzie; S Bose; S N Mitchell; Jeffrey M Witkin; R C Thompson; A Christopoulos; S Lazareno; N J M Birdsall; Frank P Bymaster; Christian Felder
Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(31):10978-83.
2008: Anantha Shekhar; William Z Potter; Jeffrey Lightfoot; John Lienemann; Sanjay Dubé; Craig Mallinckrodt; Frank P Bymaster; David L McKinzie; Christian Felder
Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia.
The American journal of psychiatry 2008;165(8):1033-9.
2008: Arieh Moussaieff; Neta Rimmerman; Tatiana Bregman; Alex Straiker; Christian Felder; Shai Shoham; Yoel Kashman; Susan M Huang; Hyosang Lee; Esther Shohami; Ken Mackie; Michael J Caterina; J Michael Walker; Ester Fride; Urij Rampampam
Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(8):3024-34.
2008: Garth Terry; Jeih-San Liow; Eyassu Chernet; Sami S Zoghbi; Lee A Phebus; Christian Felder; Johannes Tauscher; John M Schaus; Victor W Pike; Christer Halldin; Robert B Innis
Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents.
NeuroImage 2008;41(3):690-8.
2008: Fumihiko Yasuno; Amira K Brown; Sami S Zoghbi; Joseph H Krushinski; Eyassu Chernet; Johannes Tauscher; John M Schaus; Lee A Phebus; Amy K Chesterfield; Christian Felder; Robert L Gladding; Jinsoo Hong; Christer Halldin; Victor W Pike; Robert B Innis
The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(2):259-69.
2006: Amy K Dickason-Chesterfield; Stephanie R Kidd; Steven A Moore; John M Schaus; Bin Liu; George Nomikos; Christian Felder
Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors.
Cellular and molecular neurobiology 2006;26(4-6):407-23.
2006: Christian Felder; Amy K Dickason-Chesterfield; Steven A Moore
Cannabinoids biology: the search for new therapeutic targets.
Molecular interventions 2006;6(3):149-61.
2005: Steven A Moore; George Nomikos; Amy K Dickason-Chesterfield; Douglas A Schober; John M Schaus; Bai-Ping Ying; Yao-Chang Xu; Lee A Phebus; Rosa Maria A Simmons; D Li; Smriti Iyengar; Christian Felder
Identification of a high-affinity binding site involved in the transport of endocannabinoids.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(49):17852-7.
2005: Richard P Bazinet; Ho-Joo Lee; Christian Felder; Amy C Porter; Stanley I Rapoport; Thad A Rosenberger
Rapid high-energy microwave fixation is required to determine the anandamide (N-arachidonoylethanolamine) concentration of rat brain.
Neurochemical research 2005;30(5):597-601.
2005: Steven D Kahl; Christian Felder
Scintillation proximity assay.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2005;Chapter 7():Unit 7.15.
2004: Eleni T Tzavara; Frank P Bymaster; Richard J Davis; Mark R Wade; Kenneth W Perry; Jürgen Wess; David L McKinzie; Christian Felder; George Nomikos
M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(12):1410-2.
2004: Christian Felder
Strategic Research Institute G-Protein-Coupled Receptors Drug Discovery World Summit.
Expert opinion on investigational drugs 2004;13(8):1071-4.
2003: Frank P Bymaster; Christian Felder; Eleni T Tzavara; George Nomikos; David O Calligaro; David L McKinzie
Muscarinic mechanisms of antipsychotic atypicality.
Progress in neuro-psychopharmacology & biological psychiatry 2003;27(7):1125-43.
2003: Eleni T Tzavara; Frank P Bymaster; Christian Felder; Mark Wade; Jesus Gomeza; Jürgen Wess; David L McKinzie; George Nomikos
Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice.
Molecular psychiatry 2003;8(7):673-9.
2003: Frank P Bymaster; Petra A Carter; Masahisa Yamada; Jesus Gomeza; Jürgen Wess; Susan E Hamilton; Neil M Nathanson; David L McKinzie; Christian Felder
Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity.
The European journal of neuroscience 2003;17(7):1403-10.
2003: Frank P Bymaster; David L McKinzie; Christian Felder; Jürgen Wess
Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system.
Neurochemical research 2003;28(3-4):437-42.
2003: Jürgen Wess; Alokesh Duttaroy; Jesus Gomeza; Weilie Zhang; Masahisa Yamada; Christian Felder; Nadia Bernardini; Peter W Reeh
Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review.
Life sciences 2003;72(18-19):2047-54.
2003: Jürgen Wess; Alokesh Duttaroy; Weilie Zhang; Jesus Gomeza; Yinghong Cui; T Miyakawa; Frank P Bymaster; L McKinzie; Christian Felder; Kathryn G Lamping; Frank M Faraci; Chuxia Deng; Masahisa Yamada
M1-M5 muscarinic receptor knockout mice as novel tools to study the physiological roles of the muscarinic cholinergic system.
Receptors & channels 2003;9(4):279-90.
2002: Alokesh Duttaroy; Jesus Gomeza; Jai-Wei Gan; Nasir Siddiqui; Anthony Basile; W Dean Harman; Philip L Smith; Christian Felder; Allan Levey; Jürgen Wess
Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice.
Molecular pharmacology 2002;62(5):1084-93.
2002: Susan K Hemrick-Luecke; Frank P Bymaster; David C Evans; J Wess; Christian Felder
Muscarinic agonist-mediated increases in serum corticosterone levels are abolished in m(2) muscarinic acetylcholine receptor knockout mice.
The Journal of pharmacology and experimental therapeutics 2002;303(1):99-103.
2002: Amy C Porter; Frank P Bymaster; Neil DeLapp; Masahisa Yamada; Jürgen Wess; Susan E Hamilton; Neil M Nathanson; Christian Felder
M1 muscarinic receptor signaling in mouse hippocampus and cortex.
Brain research 2002;944(1-2):82-9.
2002: Allyn C Howlett; Francis Barth; Tom Bonner; G Cabral; Pierre Casellas; W A Devane; Christian Felder; Miles Herkenham; Ken Mackie; Billy R Martin; Urij Rampampam; R G Pertwee
International Union of Pharmacology. XXVII. Classification of cannabinoid receptors.
Pharmacological reviews 2002;54(2):161-202.
2002: Amy C Porter; John-Michael Sauer; Michael D Knierman; Gerald Becker; Michael J Berna; Jingqi Bao; George Nomikos; Petra Carter; Frank P Bymaster; Andrea Baker Leese; Christian Felder
Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1020-4.
2002: Frank P Bymaster; Christian Felder; Saeed Ahmed; David L McKinzie
Muscarinic receptors as a target for drugs treating schizophrenia.
Current drug targets. CNS and neurological disorders 2002;1(2):163-81.
2002: Frank P Bymaster; Christian Felder
Role of the cholinergic muscarinic system in bipolar disorder and related mechanism of action of antipsychotic agents.
Molecular psychiatry 2002;7 Suppl 1():S57-63.
2001: John S Kennedy; Frank P Bymaster; Leslie M Schuh; David O Calligaro; George Nomikos; Christian Felder; M Bernauer; Bruce J Kinon; Robert W Baker; D Hay; H J Roth; Martin Dossenbach; C Kaiser; Charles Beasley; John H Holcombe; M B Effron; Alan Breier
A current review of olanzapine's safety in the geriatric patient: from pre-clinical pharmacology to clinical data.
International journal of geriatric psychiatry 2001;16 Suppl 1():S33-61.
2001: W Daniel Stamer; S F Golightly; Yoshiaki Hosohata; E P Ryan; Amy C Porter; Eva Varga; Robert J Noecker; Christian Felder; Henry I Yamamura
Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues.
European journal of pharmacology 2001;431(3):277-86.
2001: Masahisa Yamada; Kathryn G Lamping; Alokesh Duttaroy; Weilie Zhang; Yinghong Cui; Frank P Bymaster; David L McKinzie; Christian Felder; Chu-Xia Deng; Frank M Faraci; Jürgen Wess
Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):14096-101.
2001: Frank P Bymaster; Petra A Carter; Neil DeLapp; David O Calligaro; Christian Felder
Receptor reserve of phosphoinositide-coupled muscarinic receptors in mouse hippocampus in vivo.
Brain research 2001;916(1-2):165-71.
2001: Christian Felder; Amy C Porter; T L Skillman; L Zhang; Frank P Bymaster; Neil M Nathanson; Susan E Hamilton; Jesus Gomeza; Jürgen Wess; David L McKinzie
Elucidating the role of muscarinic receptors in psychosis.
Life sciences 2001;68(22-23):2605-13.
2001: John D Salamone; Mercè Correa; Brian Carlson; Anna Wisniecki; AJ Mayorga; ES Nisenbaum; LK Nisenbaum; Christian Felder
Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents implications for cholinergic involvement in parkinsonism.
Life sciences 2001;68(22-23):2579-84.
2001: Frank P Bymaster; Petra A Carter; L Zhang; Julie F Falcone; Peter stengel; Marlene L Cohen; Harlan E Shannon; Jesus Gomeza; Jürgen Wess; Christian Felder
Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice.
Life sciences 2001;68(22-23):2473-9.
2001: Jesus Gomeza; L Zhang; E Kostenis; Christian Felder; Frank P Bymaster; J Brodkin; Harlan Shannon; B Xia; Alokesh Duttaroy; Chu-Xia Deng; Jürgen Wess
Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice.
Life sciences 2001;68(22-23):2457-66.
2001: Kenneth W Perry; Laura K Nisenbaum; Carolyn A George; Harlan E Shannon; Christian Felder; Frank P Bymaster
The muscarinic agonist xanomeline increases monoamine release and immediate early gene expression in the rat prefrontal cortex.
Biological psychiatry 2001;49(8):716-25.
2001: Amy C Porter; Christian Felder
The endocannabinoid nervous system: unique opportunities for therapeutic intervention.
Pharmacology & therapeutics 2001;90(1):45-60.
2001: Masahisa Yamada; T Miyakawa; Alokesh Duttaroy; A Yamanaka; T Moriguchi; R Makita; M Ogawa; C J Chou; B Xia; Jacqueline N Crawley; Christian Felder; Chu-Xia Deng; Jürgen Wess
Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean.
Nature 2001;410(6825):207-12.
2000: Christian Felder; Frank P Bymaster; J Ward; Neil DeLapp
Therapeutic opportunities for muscarinic receptors in the central nervous system.
Journal of medicinal chemistry 2000;43(23):4333-53.
2000: Nancy E Buckley; Kathleen L McCoy; Eva Mezey; Tom Bonner; Andreas Zimmer; Christian Felder; M Glass; A Zimmer
Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor.
European journal of pharmacology 2000;396(2-3):141-9.
2000: M W Wood; J A Segal; RJ Mark; A M Ogden; Christian Felder
Inflammatory cytokines enhance muscarinic-mediated arachidonic acid release through p38 mitogen-activated protein kinase in A2058 cells.
Journal of neurochemistry 2000;74(5):2033-40.
1999: Jesus Gomeza; L Zhang; E Kostenis; Christian Felder; Frank P Bymaster; J Brodkin; Harlan Shannon; B Xia; Chuxia Deng; Jürgen Wess
Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10483-8.
1999: Lone Jeppesen; Preben Olesen; L Hansen; MJ Sheardown; C Thomsen; Thøger Rasmussen; A F Jensen; M S Christensen; Karin Rimvall; JS Ward; CA Whitesitt; David O Calligaro; Frank P Bymaster; Neil DeLapp; Christian Felder; Harlan E Shannon; Per Sauerberg
1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.0(2,6)]heptanes as new potent muscarinic M1 agonists: structure-activity relationship for 3-aryl-2-propyn-1-yloxy and 3-aryl-2-propyn-1-ylthio derivatives.
Journal of medicinal chemistry 1999;42(11):1999-2006.
1999: H Y Yang; F Karoum; Christian Felder; H Badger; T C Wang; Sanford Markey
GC/MS analysis of anandamide and quantification of N-arachidonoylphosphatidylethanolamides in various brain regions, spinal cord, testis, and spleen of the rat.
Journal of neurochemistry 1999;72(5):1959-68.
1999: Neil DeLapp; J H McKinzie; BD Sawyer; A Vandergriff; Julie F Falcone; DB McClure; Christian Felder
Determination of [35S]guanosine-5'-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay.
The Journal of pharmacology and experimental therapeutics 1999;289(2):946-55.
1999: Jesus Gomeza; Harlan Shannon; E Kostenis; Christian Felder; L Zhang; J Brodkin; A Grinberg; H Sheng; Jürgen Wess
Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(4):1692-7.
1998: L L Lautens; X G Chiou; J D Sharp; scott young; D L Sprague; Linda S Ross; Christian Felder
Cytosolic phospholipase A2 (cPLA2) distribution in murine brain and functional studies indicate that cPLA2 does not participate in muscarinic receptor-mediated signaling in neurons.
Brain research 1998;809(1):18-30.
1998: Julius Axelrod; Christian Felder
Cannabinoid receptors and their endogenous agonist, anandamide.
Neurochemical research 1998;23(5):575-81.
1998: Christian Felder; M Glass
Cannabinoid receptors and their endogenous agonists.
Annual review of pharmacology and toxicology 1998;38():179-200.
1998: Christian Felder; K E Joyce; EM Briley; M Glass; Ken Mackie; K J Fahey; GJ Cullinan; D C Hunden; D W Johnson; M O Chaney; Gary A Koppel; M Brownstein
LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation.
The Journal of pharmacology and experimental therapeutics 1998;284(1):291-7.
1997: D Singer-Lahat; E Rojas; Christian Felder
A9 fibroblasts transfected with the m3 muscarinic receptor clone express a Ca2+ channel activated by carbachol, GTP and GDP.
The Journal of membrane biology 1997;159(1):21-8.
1997: M Glass; Christian Felder
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(14):5327-33.
1996: Christian Felder; A Nielsen; E M Briley; Miklós Palkovits; J Priller; Julius Axelrod; D N Nguyen; J M Richardson; R M Riggin; G A Koppel; S M Paul; Gerald Becker
Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat.
FEBS letters 1996;393(2-3):231-5.
1996: Elise C Kohn; Riccardo Alessandro; J Probst; W Jacobs; E Brilley; Christian Felder
Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to inhibition of adenylyl cyclase and stimulation of phospholipase A2.
The Journal of biological chemistry 1996;271(29):17476-84.
1996: D Singer-Lahat; J Liu; J Wess; Christian Felder
The third intracellular domain of the m3 muscarinic receptor determines coupling to calcium influx in transfected Chinese hamster ovary cells.
FEBS letters 1996;386(1):51-4.
1996: D Singer-Lahat; A L Ma; Christian Felder
Independent induction of morphological transformation of CHO cells by receptor-activated cyclic AMP synthesis or by receptor-operated calcium influx.
Biochemical pharmacology 1996;51(4):495-502.
1996: D Singer-Lahat; Eduardo Rojas; Christian Felder
Muscarinic receptor activated Ca2+ channels in non-excitable cells.
Progress in brain research 1996;109():195-9.
1996: P Lin; K Kusano; Q Zhang; Christian Felder; P M Geiger; L C Mahan
GABAA receptors modulate early spontaneous excitatory activity in differentiating P19 neurons.
Journal of neurochemistry 1996;66(1):233-42.
1995: Christian Felder; K E Joyce; E M Briley; J Mansouri; Ken Mackie; O Blond; Y Lai; A L Ma; R L Mitchell
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.
Molecular pharmacology 1995;48(3):443-50.
1995: J Priller; E M Briley; J Mansouri; W A Devane; Ken Mackie; Christian Felder
Mead ethanolamide, a novel eicosanoid, is an agonist for the central (CB1) and peripheral (CB2) cannabinoid receptors.
Molecular pharmacology 1995;48(2):288-92.
1995: S J Lolait; Anne-Marie O'Carroll; L C Mahan; Christian Felder; D C Button; W Scott Young; Eva Mezey; M J Brownstein
Extrapituitary expression of the rat V1b vasopressin receptor gene.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(15):6783-7.
1995: Pedro Jose; Peiying Yu; I Yamaguchi; Gilbert M Eisner; M M Mouradian; Christian Felder; Robin A Felder
Dopamine D1 receptor regulation of phospholipase C.
Hypertension research : official journal of the Japanese Society of Hypertension 1995;18 Suppl 1():S39-42.
1995: Christian Felder
Muscarinic acetylcholine receptors: signal transduction through multiple effectors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1995;9(8):619-25.
1995: Y Garces; E M Briley; Christian Felder
Vasopressin Vla receptor-stimulated phospholipase D: differential regulation of transphosphatidylation and phospholipid hydrolysis by protein kinase C [corrected].
Neuropeptides 1995;28(5):277-85.
1994: Christian Felder; D Singer-Lahat; C Mathes
Voltage-independent calcium channels. Regulation by receptors and intracellular calcium stores.
Biochemical pharmacology 1994;48(11):1997-2004.
1994: E M Briley; S J Lolait; Julius Axelrod; Christian Felder
The cloned vasopressin V1a receptor stimulates phospholipase A2, phospholipase C, and phospholipase D through activation of receptor-operated calcium channels.
Neuropeptides 1994;27(1):63-74.
1994: Elise C Kohn; Christian Felder; W Jacobs; K A Holmes; A Day; R Freer; Lance A Liotta
Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI.
Cancer research 1994;54(4):935-42.
1993: Jacqueline N Crawley; R L Corwin; J K Robinson; Christian Felder; W A Devane; Julius Axelrod
Anandamide, an endogenous ligand of the cannabinoid receptor, induces hypomotility and hypothermia in vivo in rodents.
Pharmacology, biochemistry, and behavior 1993;46(4):967-72.
1993: william wisden; E M Parker; Cathy D Mahle; D A Grisel; H P Nowak; F D Yocca; Christian Felder; Peter H Seeburg; M M Voigt
Cloning and characterization of the rat 5-HT5B receptor. Evidence that the 5-HT5B receptor couples to a G protein in mammalian cell membranes.
FEBS letters 1993;333(1-2):25-31.
1993: Christian Felder; A L Ma; E M Briley; Julius Axelrod
Muscarinic acetylcholine receptor subtypes associated with release of Alzheimer amyloid precursor derivatives activate multiple signal transduction pathways.
Annals of the New York Academy of Sciences 1993;695():15-8.
1993: Roger M Nitsch; Barbara E Slack; S A Farber; P R Borghesani; J G Schulz; C Kim; Christian Felder; John H Growdon; Richard J Wurtman
Receptor-coupled amyloid precursor protein processing.
Annals of the New York Academy of Sciences 1993;695():122-7.
1993: Christian Felder; E M Briley; Julius Axelrod; J T Simpson; Ken Mackie; W A Devane
Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7656-60.
1993: Christian Felder; F E Albrecht; T Campbell; Gilbert M Eisner; Pedro Jose
cAMP-independent, G protein-linked inhibition of Na+/H+ exchange in renal brush border by D1 dopamine agonists.
The American journal of physiology 1993;264(6 Pt 2):F1032-7.
1993: F Gusovsky; J E Lueders; E C Kohn; Christian Felder
Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-gamma. An alternative mechanism for cholinergic-induced phosphoinositide breakdown.
The Journal of biological chemistry 1993;268(11):7768-72.
1993: Christian Felder; L MacArthur; A L Ma; F Gusovsky; E C Kohn
Tumor-suppressor function of muscarinic acetylcholine receptors is associated with activation of receptor-operated calcium influx.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):1706-10.
1992: Christian Felder; J S Veluz; H L Williams; E M Briley; L A Matsuda
Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones.
Molecular pharmacology 1992;42(5):838-45.
1992: Staffan Uhlén; Y Xia; V Chhajlani; Christian Felder; Jarl E S Wikberg
[3H]-MK 912 binding delineates two alpha 2-adrenoceptor subtypes in rat CNS one of which is identical with the cloned pA2d alpha 2-adrenoceptor.
British journal of pharmacology 1992;106(4):986-95.
1992: Christian Felder; M O Poulter; J Wess
Muscarinic receptor-operated Ca2+ influx in transfected fibroblast cells is independent of inositol phosphates and release of intracellular Ca2+.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):509-13.
1991: Christian Felder; H L Williams; Julius Axelrod
A transduction pathway associated with receptors coupled to the inhibitory guanine nucleotide binding protein Gi that amplifies ATP-mediated arachidonic acid release.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6477-80.
1991: Christian Felder; A L Ma; L A Liotta; E C Kohn
The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release.
The Journal of pharmacology and experimental therapeutics 1991;257(3):967-71.
1991: R Y Kanterman; L C Mahan; E M Briley; F J Monsma; David R Sibley; Julius Axelrod; Christian Felder
Transfected D2 dopamine receptors mediate the potentiation of arachidonic acid release in Chinese hamster ovary cells.
Molecular pharmacology 1991;39(3):364-9.
1991: M M Voigt; S K McCune; R Y Kanterman; Christian Felder
The rat alpha 2-C4 adrenergic receptor gene encodes a novel pharmacological subtype.
FEBS letters 1991;278(1):45-50.
1990: Christian Felder; P Dieter; J Kinsella; K Tamura; R Y Kanterman; Julius Axelrod
A transfected m5 muscarinic acetylcholine receptor stimulates phospholipase A2 by inducing both calcium influx and activation of protein kinase C.
The Journal of pharmacology and experimental therapeutics 1990;255(3):1140-7.
1990: Pedro Jose; Robin A Felder; Christian Felder; W Y Chan
Molecular biology of adrenergic and dopamine receptors and the study of developmental nephrology.
Pediatric nephrology (Berlin, Germany) 1990;4(6):679-85.
1990: Christian Felder; M M Piccio; A M McKelvey; K T Nakamura; Josée Robillard; Pedro Jose
Ontogeny of renal beta adrenoceptors in the sheep.
Pediatric nephrology (Berlin, Germany) 1990;4(6):635-9.
1990: R Y Kanterman; A L Ma; E M Briley; Julius Axelrod; Christian Felder
Muscarinic receptors mediate the release of arachidonic acid from spinal cord and hippocampal neurons in primary culture.
Neuroscience letters 1990;118(2):235-7.
1990: Christian Felder; T Campbell; F Albrecht; Pedro Jose
Dopamine inhibits Na(+)-H+ exchanger activity in renal BBMV by stimulation of adenylate cyclase.
The American journal of physiology 1990;259(2 Pt 2):F297-303.
1990: Christian Felder; F Albrecht; Gilbert M Eisner; Pedro Jose
The signal transducer for the dopamine-1 regulated sodium transport in renal cortical brush border membrane vesicles.
American journal of hypertension 1990;3(6 Pt 2):47S-50S.
1990: J A Cox; Christian Felder; R C Henneberry
Differential expression of excitatory amino acid receptor subtypes in cultured cerebellar neurons.
Neuron 1990;4(6):941-7.
1990: R Y Kanterman; Christian Felder; Douglas E Brenneman; A L Ma; S Fitzgerald; Julius Axelrod
Alpha 1-adrenergic receptor mediates arachidonic acid release in spinal cord neurons independent of inositol phospholipid turnover.
Journal of neurochemistry 1990;54(4):1225-32.
1990: M Brunswick; E Bonvini; M Francis; Christian Felder; T Hoffman; James J Mond
Absence of demonstrable phospholipid turnover in B cells stimulated by low mitogenic concentrations of dextran-anti-immunoglobulin conjugates.
European journal of immunology 1990;20(4):855-61.
1990: Christian Felder; R Y Kanterman; A L Ma; Julius Axelrod
Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2187-91.
1990: R Y Kanterman; Julius Axelrod; Christian Felder
Alpha-1 adrenergic receptor mediates the release of arachidonic acid in spinal cord neurons independent of phosphatidylinositol-specific phospholipase C.
Advances in second messenger and phosphoprotein research 1990;24():158-63.
1989: Christian Felder; R Y Kanterman; A L Ma; Julius Axelrod
A transfected m1 muscarinic acetylcholine receptor stimulates adenylate cyclase via phosphatidylinositol hydrolysis.
The Journal of biological chemistry 1989;264(34):20356-62.
1989: Robin A Felder; Christian Felder; Gilbert M Eisner; Pedro Jose
The dopamine receptor in adult and maturing kidney.
The American journal of physiology 1989;257(3 Pt 2):F315-27.
1989: Christian Felder; A M McKelvey; Miriam Gitler; Gilbert M Eisner; Pedro Jose
Dopamine receptor subtypes in renal brush border and basolateral membranes.
Kidney international 1989;36(2):183-93.
1989: Christian Felder; M Blecher; Pedro Jose
Dopamine-1-mediated stimulation of phospholipase C activity in rat renal cortical membranes.
The Journal of biological chemistry 1989;264(15):8739-45.
1989: Christian Felder; A L Ma; Bruce R Conklin
Carbachol-induced reverse transformation of Chinese hamster ovary cells transfected with and expressing the m5 muscarinic acetylcholine receptor.
FEBS letters 1989;245(1-2):75-9.
1989: Christian Felder; Pedro Jose; Julius Axelrod
The dopamine-1 agonist, SKF 82526, stimulates phospholipase-C activity independent of adenylate cyclase.
The Journal of pharmacology and experimental therapeutics 1989;248(1):171-5.
1987: Christian Felder; J E Robillard; S Roy; Pedro Jose
Severe chloride deficiency in the neonate: the canine puppy as an animal model.
Pediatric research 1987;21(5):497-501.
1983: Nasir Bashirelahi; Christian Felder; J D Young
Characterization and stabilization of progesterone receptors in human benign prostatic hypertrophy.
Journal of steroid biochemistry 1983;18(6):801-9.