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Agnieszka Bzowska

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Beata Wielgus-Kutrowska; Tsutomu Yokomatsu; Katarzyna Breer; Alicja Dyzma; Agnieszka Girstun; Mariko Hashimoto; Sadao Hikishima; Marta Narczyk; Krzysztof Staroń; Agnieszka Bzowska
Trimeric purine nucleoside phosphorylase: exploring postulated one-third-of-the-sites binding in the transition state.
Zoran Štefanić; Agnieszka Bzowska; Goran Mikleušević; Marta Narczyk; Beata Wielgus-Kutrowska; Marija Luić
New phosphate binding sites in the crystal structure of Escherichia coli purine nucleoside phosphorylase complexed with phosphate and formycin A.
Goran Mikleušević; Marta Narczyk; Zoran Stefanić; Beata Wielgus-Kutrowska; Agnieszka Bzowska; Marija Luić
Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies.

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All Publications

2012: Beata Wielgus-Kutrowska; Tsutomu Yokomatsu; Katarzyna Breer; Alicja Dyzma; Agnieszka Girstun; Mariko Hashimoto; Sadao Hikishima; Marta Narczyk; Krzysztof Staroń; Agnieszka Bzowska
Trimeric purine nucleoside phosphorylase: exploring postulated one-third-of-the-sites binding in the transition state.
Bioorganic & medicinal chemistry 2012;20(22):6758-69.
2012: Zoran Štefanić; Agnieszka Bzowska; Goran Mikleušević; Marta Narczyk; Beata Wielgus-Kutrowska; Marija Luić
New phosphate binding sites in the crystal structure of Escherichia coli purine nucleoside phosphorylase complexed with phosphate and formycin A.
FEBS letters 2012;586(7):967-71.
2011: Goran Mikleušević; Marta Narczyk; Zoran Stefanić; Beata Wielgus-Kutrowska; Agnieszka Bzowska; Marija Luić
Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies.
Biochimie 2011;93(9):1610-22.
2010: Katarzyna Breer; Ljubica Glavas-Obrovac; Mirjana Suver; Sadao Hikishima; Mariko Hashimoto; Tsutomu Yokomatsu; Beata Wielgus-Kutrowska; Lucyna Magnowska; Agnieszka Bzowska
9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase.
The FEBS journal 2010;277(7):1747-60.
2010: Sadao Hikishima; Mariko Hashimoto; Lucyna Magnowska; Agnieszka Bzowska; Tsutomu Yokomatsu
Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs.
Bioorganic & medicinal chemistry 2010;18(6):2275-84.
2010: Katarzyna Breer; Beata Wielgus-Kutrowska; Agnieszka Girstun; Krzysztof Staroń; Mariko Hashimoto; Sadao Hikishima; Tsutomu Yokomatsu; Agnieszka Bzowska
Overexpressed proteins may act as mops removing their ligands from the host cells: a case study of calf PNP.
Biochemical and biophysical research communications 2010;391(2):1203-9.
2010: Grzegorz Chojnowski; Katarzyna Breer; Marta Narczyk; Beata Wielgus-Kutrowska; Honorata Czapinska; Mariko Hashimoto; Sadao Hikishima; Tsutomu Yokomatsu; Matthias Bochtler; Agnieszka Girstun; Krzysztof Staroń; Agnieszka Bzowska
1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state.
Biochemical and biophysical research communications 2010;391(1):703-8.
2008: Katarzyna Breer; Agnieszka Girstun; Beata Wielgus-Kutrowska; Krzysztof Staroń; Agnieszka Bzowska
Overexpression, purification and characterization of functional calf purine nucleoside phosphorylase (PNP).
Protein expression and purification 2008;61(2):122-30.
2008: Jan M Antosiewicz; Katarzyna Breer; Agnieszka Bzowska; Beata Wielgus-Kutrowska
On the analysis of fluorimetric titration curves of purine nucleoside phosphorylase.
Nucleic acids symposium series (2004) 2008;(52):671-2.
2008: Agnieszka Bzowska; Lucyna Magnowska
Simple and universal method to determine dissociation constants for enzyme/ligand complexes.
Nucleic acids symposium series (2004) 2008;(52):669-70.
2008: Katarzyna Breer; Beata Wielgus-Kutrowska; Mariko Hashimoto; Sadao Hikishima; Tsutomu Yokomatsu; Roman H Szczepanowski; Matthias Bochtler; Agnieszka Girstun; Krzysztof Starón; Agnieszka Bzowska
Thermodynamic studies of interactions of calf spleen PNP with acyclic phosphonate inhibitors.
Nucleic acids symposium series (2004) 2008;(52):663-4.
2008: Tomoyuki Yatsu; Mariko Hashimoto; Sadao Hikishima; Lucyna Magnowska; Agnieszka Bzowska; Tsutomu Yokomatsu
9-Deazaguanine derivatives: synthesis and inhibitory properties as multi-substrate analogue inhibitors of mammalian PNPs.
Nucleic acids symposium series (2004) 2008;(52):661-2.
2007: Sadao Hikishima; Mariko Hashimoto; Lucyna Magnowska; Agnieszka Bzowska; Tsutomu Yokomatsu
Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP.
Bioorganic & medicinal chemistry letters 2007;17(15):4173-7.
2007: Beata Wielgus-Kutrowska; Jan M Antosiewicz; M Długosz; Antonín Holý; Agnieszka Bzowska
Towards the mechanism of trimeric purine nucleoside phosphorylases: stopped-flow studies of binding of multisubstrate analogue inhibitor - 2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine.
Biophysical chemistry 2007;125(2-3):260-8.
2007: Katarzyna Stepniak; Agnieszka Girstun; Beata Wielgus-Kutrowska; Krzysztof Staroń; Agnieszka Bzowska
Cloning, expression, purification, and some properties of calf purine nucleoside phosphorylase.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):855-9.
2007: Jacek Wierzchowski; Beata Iwanska; Agnieszka Bzowska; David Shugar
Interactions of calf spleen purine nucleoside phosphorylase with formycin B and its aglycone - spectroscopic and kinetic studies.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):849-54.
2007: Katarzyna Stepniak; Biserka Zinić; Jacek Wierzchowski; Agnieszka Bzowska
Fluorescence studies of calf spleen purine nucleoside phosphorylase (PNP) complexes with guanine and 9-deazaguanine.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):841-7.
2007: Ljubica Glavas-Obrovac; Mirjana Suver; Sadao Hikishima; Tsutomu Yokomatsu; Agnieszka Bzowska
Inhibitory properties of nucleotides with difluoromethylenephosphonic acid as a phosphate mimic versus calf spleen purine nucleoside phosphorylase and effect of these analogues on the viability of human blood lymphocytes.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):989-93.
2007: Jan M Antosiewicz; Beata Wielgus-Kutrowska; Maciej Długosz; Antonin Holy; Agnieszka Bzowska
Kinetics of binding of multisubstrate analogue inhibitor (2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine) with trimeric purine nucleoside phosphorylase.
Nucleosides, nucleotides & nucleic acids 2007;26(8-9):969-74.
2007: Mariko Hashimoto; Sadao Hikishima; Lucyna Magnowska; Agnieszka Bzowska; Tsutomu Yokomatsu
Synthesis and evaluation of 9-deazaguanine derivatives as multi-substrate analogue inhibitors of PNP.
Nucleic acids symposium series (2004) 2007;(51):431-2.
2006: Anna Modrak-Wójcik; Katarzyna Stepniak; Vladimir Akoev; Michał Zółkiewski; Agnieszka Bzowska
Molecular architecture of E. coli purine nucleoside phosphorylase studied by analytical ultracentrifugation and CD spectroscopy.
Protein science : a publication of the Protein Society 2006;15(7):1794-800.
2006: Beata Wielgus-Kutrowska; Agnieszka Bzowska
Probing the mechanism of purine nucleoside phosphorylase by steady-state kinetic studies and ligand binding characterization determined by fluorimetric titrations.
Biochimica et biophysica acta 2006;1764(5):887-902.
2005: Joachim Behlke; Gertraud Koellner; Agnieszka Bzowska
Oligomeric structure of mammalian purine nucleoside phosphorylase in solution determined by analytical ultracentrifugation.
Zeitschrift für Naturforschung. C, Journal of biosciences 2005;60(11-12):927-31.
2005: M Długosz; Agnieszka Bzowska; Jan M Antosiewicz
Stopped-flow studies of guanine binding by calf spleen purine nucleoside phosphorylase.
Biophysical chemistry 2005;115(1):67-76.
2005: Beata Wielgus-Kutrowska; Agnieszka Bzowska
Kinetic properties of Cellulomonas sp. purine nucleoside phosphorylase with typical and non-typical substrates: implications for the reaction mechanism.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):471-6.
2005: Kinga Banach; Elzbieta Bojarska; Zygmunt Kazimierczuk; Lucyna Magnowska; Agnieszka Bzowska
Kinetic model of oxidation catalyzed by xanthine oxidase-the final enzyme in degradation of purine nucleosides and nucleotides.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):465-9.
2005: Jacek Wierzchowski; Katarzyna Stepniak; Agnieszka Bzowska; David Shugar
Spectroscopic and kinetic studies of interactions of calf spleen purine nucleoside phosphorylase with 8-azaguanine, and its 9-(2-phosphonylmethoxyethyl) derivative.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):459-64.
2004: Agnieszka Bzowska; Gertraud Koellner; Beata Wielgus-Kutrowska; Albrecht Stroh; Grzegorz Raszewski; Antonín Holý; Thomas Steiner; Joachim Frank
Crystal structure of calf spleen purine nucleoside phosphorylase with two full trimers in the asymmetric unit: important implications for the mechanism of catalysis.
Journal of molecular biology 2004;342(3):1015-32.
2004: Jacek Wierzchowski; Agnieszka Bzowska; Katarzyna Stepniak; David Shugar
Interactions of calf spleen purine nucleoside phosphorylase with 8-azaguanine, and a bisubstrate analogue inhibitor: implications for the reaction mechanism.
Zeitschrift für Naturforschung. C, Journal of biosciences 2004;59(9-10):713-25.
2004: Marija Luić; Gertraud Koellner; Tsutomu Yokomatsu; Shiroshi Shibuya; Agnieszka Bzowska
Calf spleen purine-nucleoside phosphorylase: crystal structure of the binary complex with a potent multisubstrate analogue inhibitor.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 8):1417-24.
2003: Gertraud Koellner; Albrecht Stroh; Grzegorz Raszewski; Antonín Holý; Agnieszka Bzowska
Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with multisubstrate analogue inhibitor with 2,6-diaminopurine aglycone.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1699-702.
2003: Beata Wielgus-Kutrowska; Joachim Frank; Antonín Holý; Gertraud Koellner; Agnieszka Bzowska
Interactions of trimeric purine nucleoside phosphorylases with ground state analogues--calorimetric and fluorimetric studies.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1695-8.
2003: Monika Iwanow; Lucyna Magnowska; Tsutomu Yokomatsu; Shiroshi Shibuya; Agnieszka Bzowska
Interactions of potent multisubstrate analogue inhibitors with purine nucleoside phosphorylase from calf spleen--kinetic and spectrofluorimetric studies.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):1567-70.
2002: Beata Wielgus-Kutrowska; Agnieszka Bzowska; Jan Tebbe; Gertraud Koellner; David Shugar
Purine nucleoside phosphorylase from Cellulomonas sp.: physicochemical properties and binding of substrates determined by ligand-dependent enhancement of enzyme intrinsic fluorescence, and by protective effects of ligands on thermal inactivation of the enzyme.
Biochimica et biophysica acta 2002;1597(2):320-34.
2002: Agnieszka Bzowska
Calf spleen purine nucleoside phosphorylase: complex kinetic mechanism, hydrolysis of 7-methylguanosine, and oligomeric state in solution.
Biochimica et biophysica acta 2002;1596(2):293-317.
2002: Gertraud Koellner; Agnieszka Bzowska; Beata Wielgus-Kutrowska; Marija Luić; Thomas Steiner; Wolfram Saenger; Janusz Stepiński
Open and closed conformation of the E. coli purine nucleoside phosphorylase active center and implications for the catalytic mechanism.
Journal of molecular biology 2002;315(3):351-71.
2001: M Luić; Gertraud Koellner; David Shugar; Wolfram Saenger; Agnieszka Bzowska
Calf spleen purine nucleoside phosphorylase: structure of its ternary complex with an N(7)-acycloguanosine inhibitor and a phosphate anion.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 1):30-6.
2000: Agnieszka Bzowska; Ewa Kulikowska; David Shugar
Purine nucleoside phosphorylases: properties, functions, and clinical aspects.
Pharmacology & therapeutics 2000;88(3):349-425.
1999: Jan Tebbe; Agnieszka Bzowska; Beata Wielgus-Kutrowska; Werner Schröder; Zygmunt Kazimierczuk; David Shugar; Wolfram Saenger; Gertraud Koellner
Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs.
Journal of molecular biology 1999;294(5):1239-55.
1999: Agnieszka Bzowska; Lucyna Magnowska; Zygmunt Kazimierczuk
Synthesis of 6-aryloxy- and 6-arylalkoxy-2-chloropurines and their interactions with purine nucleoside phosphorylase from Escherichia coli.
Zeitschrift für Naturforschung. C, Journal of biosciences 1999;54(12):1055-67.
1999: Jacek Wierzchowski; Ewa Kulikowska; Agnieszka Bzowska; Antonin Holy; Lucyna Magnowska; David Shugar
Interactions of calf spleen purine nucleoside phosphorylase with antiviral acyclic nucleoside phosphonate inhibitors: kinetics and emission studies.
Nucleosides & nucleotides 1999;18(4-5):875-6.
1998: Agnieszka Bzowska; Jan Tebbe; M Luić; Beata Wielgus-Kutrowska; Werner Schröder; David Shugar; Wolfram Saenger; Gertraud Koellner
Crystallization and preliminary X-ray studies of purine nucleoside phosphorylase from Cellulomonas sp.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 5):1061-3.
1998: Gertraud Koellner; M Luić; David Shugar; Wolfram Saenger; Agnieszka Bzowska
Crystal structure of the ternary complex of E. coli purine nucleoside phosphorylase with formycin B, a structural analogue of the substrate inosine, and phosphate (Sulphate) at 2.1 A resolution.
Journal of molecular biology 1998;280(1):153-66.
1998: Agnieszka Bzowska; Zygmunt Kazimierczuk; F Seela
7-Deazapurine 2'-deoxyribofuranosides are noncleavable competitive inhibitors of Escherichia coli purine nucleoside phosphorylase (PNP).
Acta biochimica Polonica 1998;45(3):755-68.
1998: Ewa Kulikowska; Agnieszka Bzowska; Antonin Holy; Lucyna Magnowska; David Shugar
Antiviral acyclic nucleoside phosphonate analogues as inhibitors of purine nucleoside phosphorylase.
Advances in experimental medicine and biology 1998;431():747-52.
1998: Beata Wielgus-Kutrowska; Jan Tebbe; Werner Schröder; Marija Luic; David Shugar; Wolfram Saenger; Gertraud Koellner; Agnieszka Bzowska
Cellulomonas sp. purine nucleoside phosphorylase (PNP). Comparison with human and E. coli enzymes.
Advances in experimental medicine and biology 1998;431():259-64.
1997: Gertraud Koellner; M Luić; David Shugar; Wolfram Saenger; Agnieszka Bzowska
Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with hypoxanthine at 2.15 A resolution.
Journal of molecular biology 1997;265(2):202-16.
1997: Beata Wielgus-Kutrowska; Ewa Kulikowska; Jacek Wierzchowski; Agnieszka Bzowska; David Shugar
Nicotinamide riboside, an unusual, non-typical, substrate of purified purine-nucleoside phosphorylases.
European journal of biochemistry / FEBS 1997;243(1-2):408-14.
1996: Agnieszka Bzowska; Ewa Kulikowska; N E Poopeiko; David Shugar
Kinetics of phosphorolysis of 3-(beta-D-ribofuranosyl)adenine and 3-(beta-D-ribofuranosyl)hypoxanthine, non-conventional substrates of purine-nucleoside phosphorylase.
European journal of biochemistry / FEBS 1996;239(1):229-34.
1995: Agnieszka Bzowska; Zygmunt Kazimierczuk
2-Chloro-2'-deoxyadenosine (cladribine) and its analogues are good substrates and potent selective inhibitors of Escherichia coli purine-nucleoside phosphorylase.
European journal of biochemistry / FEBS 1995;233(3):886-90.
1995: Agnieszka Bzowska; M Luić; Werner Schröder; David Shugar; Wolfram Saenger; Gertraud Koellner
Calf spleen purine nucleoside phosphorylase: purification, sequence and crystal structure of its complex with an N(7)-acycloguanosine inhibitor.
FEBS letters 1995;367(3):214-8.
1994: Agnieszka Bzowska; A V Ananiev; N Ramzaeva; E Alksins; J A Maurins; Ewa Kulikowska; David Shugar
Purine nucleoside phosphorylase: inhibition by purine N(7)- and N(9)-acyclonucleosides; and substrate properties of 7-beta-D-ribofuranosylguanine and 7-beta-D-ribofuranosylhypoxanthine.
Biochemical pharmacology 1994;48(5):937-47.
1993: Agnieszka Bzowska; Ewa Kulikowska; David Shugar
Linear free energy relationships for N(7)-substituted guanosines as substrates of calf spleen purine nucleoside phosphorylase. Possible role of N(7)-protonation as an intermediary in phosphorolysis.
Zeitschrift für Naturforschung. C, Journal of biosciences 1993;48(9-10):803-11.
1992: Agnieszka Bzowska; Ewa Kulikowska; David Shugar
Formycins A and B and some analogues: selective inhibitors of bacterial (Escherichia coli) purine nucleoside phosphorylase.
Biochimica et biophysica acta 1992;1120(3):239-47.
1991: Agnieszka Bzowska; Ewa Kulikowska; David Shugar; B Y Chen; B Lindborg; N G Johansson
Acyclonucleoside analogue inhibitors of mammalian purine nucleoside phosphorylase.
Biochemical pharmacology 1991;41(12):1791-803.
1990: Agnieszka Bzowska; Ewa Kulikowska; David Shugar
Properties of purine nucleoside phosphorylase (PNP) of mammalian and bacterial origin.
Zeitschrift für Naturforschung. C, Journal of biosciences 1990;45(1-2):59-70.
1989: Agnieszka Bzowska; David Shugar
Properties of 5'-AMP deaminase and its inhibitors with the aid of a continuous fluorimetric assay with formycin-5'-phosphate as substrate.
Zeitschrift für Naturforschung. C, Journal of biosciences 1989;44(7-8):581-9.
1988: Agnieszka Bzowska; Ewa Kulikowska; Edward Darzynkiewicz; David Shugar
Purine nucleoside phosphorylase. Structure-activity relationships for substrate and inhibitor properties of N-1-, N-7-, and C-8-substituted analogues; differentiation of mammalian and bacterial enzymes with N-1-methylinosine and guanosine.
The Journal of biological chemistry 1988;263(19):9212-7.
1987: Agnieszka Bzowska; Ewa Kulikowska; Edward Darzynkiewicz; David Shugar
Properties of 7-alkylguanosines as substrates of purine nucleoside phosphorylase.
Nucleic acids symposium series 1987;(18):53-6.
1986: Ewa Kulikowska; Agnieszka Bzowska; J Wierzchowski; David Shugar
Properties of two unusual, and fluorescent, substrates of purine-nucleoside phosphorylase: 7-methylguanosine and 7-methylinosine.
Biochimica et biophysica acta 1986;874(3):355-63.