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Di Chen

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Kristin Landis-Piwowar; Robert Foldes; Tak Hang Chan; Di Chen; Qingping Dou
Novel epigallocatechin gallate analogs as potential anticancer agents: a patent review (2009 - present).
Christine Neslund-Dudas; Benjamin A Rybicki; Sara Schmitt; Min Shen; Di Chen; Qiuzhi Cui; Ashoka Kandegedara; Bharati Mitra; Qingping Dou
Association of metals and proteasome activity in erythrocytes of prostate cancer patients and controls.
Di Chen; Qiuzhi Cui; Tak Hang Chan; Sreedhar Pamu; Qingping Dou
Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells.

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All Publications

2013: Kristin Landis-Piwowar; Robert Foldes; Tak Hang Chan; Di Chen; Qingping Dou
Novel epigallocatechin gallate analogs as potential anticancer agents: a patent review (2009 - present).
Expert opinion on therapeutic patents 2013;23(2):189-202.
2012: Christine Neslund-Dudas; Benjamin A Rybicki; Sara Schmitt; Min Shen; Di Chen; Qiuzhi Cui; Ashoka Kandegedara; Bharati Mitra; Qingping Dou
Association of metals and proteasome activity in erythrocytes of prostate cancer patients and controls.
Biological trace element research 2012;149(1):5-9.
2012: Di Chen; Qiuzhi Cui; Tak Hang Chan; Sreedhar Pamu; Qingping Dou
Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells.
Bioorganic & medicinal chemistry 2012;20(9):3031-7.
2012: Di Chen; Qiuzhi C Cui; Dejuan Kong; Asfar S Azmi; Sanjeev Banerjee; Qingping Dou
Activation of AMP-activated protein kinase by 3,3'-Diindolylmethane (DIM) is associated with human prostate cancer cell death in vitro and in vivo.
PloS one 2012;7(10):e47186.
2011: Di Chen; M Frezza; S Schmitt; J Kanwar; Qingping Dou
Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives.
Current cancer drug targets 2011;11(3):239-53.
2011: Hongbiao Huang; Di Chen; Shujue Li; Xiaofen Li; Ningning Liu; Xiaoyu Lu; Shouting Liu; Kai Zhao; Canguo Zhao; Haiping Guo; Changshan Yang; Ping Zhou; Xiaoxian Dong; Change Zhang; Qingping Dou; Jinbao Liu
Gambogic acid enhances proteasome inhibitor-induced anticancer activity.
Cancer letters 2011;301(2):221-8.
2011: Di Chen; Sheng Biao Wan; Huanjie Yang; Jian Yuan; Tak Hang Chan; Qingping Dou
EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment.
Advances in clinical chemistry 2011;53():155-77.
2010: Sheng Biao Wan; Huanjie Yang; Zhongyuan Zhou; Qiuzhi Cindy Cui; Di Chen; Jyoti Kanwar; Imthiyaz Mohammad; Qingping Dou; Tak Hang Chan
Evaluation of curcumin acetates and amino acid conjugates as proteasome inhibitors.
International journal of molecular medicine 2010;26(4):447-55.
2010: Di Chen; Qingping Dou
The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention.
Current protein & peptide science 2010;11(6):459-70.
2010: Kristin Landis-Piwowar; Di Chen; Tak Hang Chan; Qingping Dou
Inhibition of catechol-Omicron-methyltransferase activity in human breast cancer cells enhances the biological effect of the green tea polyphenol (-)-EGCG.
Oncology reports 2010;24(2):563-9.
2010: Yan Xiao; Di Chen; Xia Zhang; Qiuzhi Cui; Yuhua Fan; Caifeng Bi; Qingping Dou
Molecular study on copper-mediated tumor proteasome inhibition and cell death.
International journal of oncology 2010;37(1):81-7.
2010: Michael Frezza; Sarmad Hindo; Di Chen; Andrew Davenport; Sara Schmitt; Dajena Tomco; Qingping Dou
Novel metals and metal complexes as platforms for cancer therapy.
Current pharmaceutical design 2010;16(16):1813-25.
2010: Huanjie Yang; Dong Kui Sun; Di Chen; Qiuzhi Cindy Cui; Yan Yan Gu; Tao Jiang; Wei Chen; Sheng Biao Wan; Qingping Dou
Antitumor activity of novel fluoro-substituted (-)-epigallocatechin-3-gallate analogs.
Cancer letters 2010;292(1):48-53.
2010: Haijun Zhang; Di Chen; Jonathan Ringler; Wei Chen; Qiuzhi Cindy Cui; Stephen Ethier; Qingping Dou; Guojun Wu
Disulfiram treatment facilitates phosphoinositide 3-kinase inhibition in human breast cancer cells in vitro and in vivo.
Cancer research 2010;70(10):3996-4004.
2010: Ayman Khdair; Di Chen; Yogesh Patil; Linan Ma; Qingping Dou; Malathy Puthan Veedu Shekhar; Jayanth Panyam
Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance.
Journal of controlled release : official journal of the Controlled Release Society 2010;141(2):137-44.
2009: Raul A Barrea; Di Chen; Thomas C Irving; Qingping Dou
Synchrotron X-ray imaging reveals a correlation of tumor copper speciation with Clioquinol's anticancer activity.
Journal of cellular biochemistry 2009;108(1):96-105.
2009: Michael Frezza; Sarmad Hindo; Dajena Tomco; Marco M Allard; Qiuzhi Cindy Cui; Mary Jane Heeg; Di Chen; Qingping Dou; Claudio N Verani
Comparative activities of nickel(II) and zinc(II) complexes of asymmetric [NN'O] ligands as 26S proteasome inhibitors.
Inorganic chemistry 2009;48(13):5928-37.
2009: Huanjie Yang; Ping Zhou; Hongbiao Huang; Di Chen; Ningfang Ma; Qiuzhi Cindy Cui; Shouxing Shen; Weihua Dong; Xiaoyan Zhang; Wen Lian; Xuejun Wang; Qingping Dou; Jinbao Liu
Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo.
International journal of cancer. Journal international du cancer 2009;124(10):2450-9.
2009: Kannagi Chinnakannu; Di Chen; Yiwei Li; Zhiwei Wang; Qingping Dou; G Prem-Veer Reddy; Asfar S Azmi
Cell cycle-dependent effects of 3,3'-diindolylmethane on proliferation and apoptosis of prostate cancer cells.
Journal of cellular physiology 2009;219(1):94-9.
2009: Guoqing Shi; Di Chen; Guangshu Zhai; Marina S Chen; Qiuzhi Cindy Cui; Qunfang Zhou; Bin He; Qingping Dou; Guibin Jiang
The proteasome is a molecular target of environmental toxic organotins.
Environmental health perspectives 2009;117(3):379-86.
2009: Di Chen; Vesna Milacic; Michael Frezza; Qingping Dou
Metal complexes, their cellular targets and potential for cancer therapy.
Current pharmaceutical design 2009;15(7):777-91.
2008: Xia Zhang; Caifeng Bi; Yuhua Fan; Qiuzhi Cui; Di Chen; Yan Xiao; Qingping Dou
Induction of tumor cell apoptosis by taurine Schiff base copper complex is associated with the inhibition of proteasomal activity.
International journal of molecular medicine 2008;22(5):677-82.
2008: Qingping Dou; K R Landis-Piwowar; Di Chen; C Huo; S B Wan; T H Chan
Green tea polyphenols as a natural tumour cell proteasome inhibitor.
Inflammopharmacology 2008;16(5):208-12.
2008: C Huo; S B Wan; W H Lam; L Li; Z Wang; K R Landis-Piwowar; Di Chen; Qingping Dou; T H Chan
The challenge of developing green tea polyphenols as therapeutic agents.
Inflammopharmacology 2008;16(5):248-52.
2008: Di Chen; Samuel C Falsetti; Michael Frezza; Vesna Milacic; Aslamuzzaman Kazi; Qiuzhi Cindy Cui; Timothy E Long; Edward Turos; Qingping Dou
Anti-tumor activity of N-thiolated beta-lactam antibiotics.
Cancer letters 2008;268(1):63-9.
2008: Vesna Milacic; Di Chen; Lorena Giovagnini; Alejandro Diez; Dolores Fregona; Qingping Dou
Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity.
Toxicology and applied pharmacology 2008;231(1):24-33.
2008: Zhiyong Yu; Xu L Qin; Yan Y Gu; Di Chen; Qiuzhi Cindy Cui; Tao Jiang; Sheng Biao Wan; Qingping Dou
Prodrugs of fluoro-substituted benzoates of EGC as tumor cellular proteasome inhibitors and apoptosis inducers.
International journal of molecular sciences 2008;9(6):951-61.
2008: Di Chen; Qingping Dou
Tea polyphenols and their roles in cancer prevention and chemotherapy.
International journal of molecular sciences 2008;9(7):1196-206.
2008: Huanjie Yang; Kristin R Landis-Piwowar; Di Chen; Vesna Milacic; Qingping Dou
Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.
Current protein & peptide science 2008;9(3):227-39.
2008: Michael Frezza; Julio Garay; Di Chen; Cindy Cui; Edward Turos; Qingping Dou
Induction of tumor cell apoptosis by a novel class of N-thiolated beta-lactam antibiotics with structural modifications at N1 and C3 of the lactam ring.
International journal of molecular medicine 2008;21(6):689-95.
2008: Di Chen; Qingping Dou
New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer.
Expert opinion on therapeutic targets 2008;12(6):739-48.
2008: Lihua Li; Huanjie Yang; Di Chen; Cindy Cui; Qingping Dou
Disulfiram promotes the conversion of carcinogenic cadmium to a proteasome inhibitor with pro-apoptotic activity in human cancer cells.
Toxicology and applied pharmacology 2008;229(2):206-14.
2008: Di Chen; Vesna Milacic; Marina S Chen; Sheng Biao Wan; Wai Har Lam; C Huo; Kristin R Landis-Piwowar; Qiuzhi Cindy Cui; A Wali; Tak Hang Chan; Qingping Dou
Tea polyphenols, their biological effects and potential molecular targets.
Histology and histopathology 2008;23(4):487-96.
2007: Di Chen; Michael Frezza; Rajendra Shakya; Qiuzhi Cindy Cui; Vesna Milacic; Claudio N Verani; Qingping Dou
Inhibition of the proteasome activity by gallium(III) complexes contributes to their anti prostate tumor effects.
Cancer research 2007;67(19):9258-65.
2007: Ahmed O Kaseb; Kannagi Chinnakannu; Di Chen; Arun Sivanandam; Sheela Tejwani; Mani Menon; Qingping Dou; G Prem-Veer Reddy
Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer.
Cancer research 2007;67(16):7782-8.
2007: Xiaohua Li; Di Chen; Shuping Yin; Yonghong Meng; Huanjie Yang; Kristin R Landis-Piwowar; Yiwei Li; Asfar S Azmi; G Prem-Veer Reddy; Qingping Dou; Shijie Sheng
Maspin augments proteasome inhibitor-induced apoptosis in prostate cancer cells.
Journal of cellular physiology 2007;212(2):298-306.
2007: Kristin R Landis-Piwowar; Congde Huo; Di Chen; Vesna Milacic; Guoqing Shi; Tak Hang Chan; Qingping Dou
A novel prodrug of the green tea polyphenol (-)-epigallocatechin-3-gallate as a potential anticancer agent.
Cancer research 2007;67(9):4303-10.
2007: Haiyan Pang; Di Chen; Qiuzhi Cindy Cui; Qingping Dou
Sodium diethyldithiocarbamate, an AIDS progression inhibitor and a copper-binding compound, has proteasome-inhibitory and apoptosis-inducing activities in cancer cells.
International journal of molecular medicine 2007;19(5):809-16.
2007: Di Chen; Qiuzhi Cindy Cui; Huanjie Yang; Raul A Barrea; Asfar S Azmi; Shijie Sheng; Bing Yan; G Prem-Veer Reddy; Qingping Dou
Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts.
Cancer research 2007;67(4):1636-44.
2007: Di Chen; Kristin R Landis-Piwowar; Marina S Chen; Qingping Dou
Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts.
Breast cancer research : BCR 2007;9(6):R80.
2007: Di Chen; Marina S Chen; Qiuzhi Cindy Cui; Huanjie Yang; Qingping Dou
Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells.
Frontiers in bioscience : a journal and virtual library 2007;12():1935-45.
2007: Kenyon G Daniel; Di Chen; Bing Yan; Qingping Dou
Copper-binding compounds as proteasome inhibitors and apoptosis inducers in human cancer.
Frontiers in bioscience : a journal and virtual library 2007;12():135-44.
2006: Kristin R Landis-Piwowar; Vesna Milacic; Di Chen; Huanjie Yang; Yunfeng Zhao; Tak Hang Chan; Bing Yan; Qingping Dou
The proteasome as a potential target for novel anticancer drugs and chemosensitizers.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2006;9(6):263-73.
2006: Shreelekha Adsule; Vivek Barve; Di Chen; Fakhara Ahmed; Qingping Dou; Subhash Padhye; Asfar S Azmi
Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells.
Journal of medicinal chemistry 2006;49(24):7242-6.
2006: Vesna Milacic; Di Chen; Luca Ronconi; Kristin R Landis-Piwowar; Dolores Fregona; Qingping Dou
A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts.
Cancer research 2006;66(21):10478-86.
2006: Di Chen; Qiuzhi Cindy Cui; Huanjie Yang; Qingping Dou
Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity.
Cancer research 2006;66(21):10425-33.
2006: Kenyon G Daniel; Kristin R Landis-Piwowar; Di Chen; Sheng Biao Wan; Tak Hang Chan; Qingping Dou
Methylation of green tea polyphenols affects their binding to and inhibitory poses of the proteasome beta5 subunit.
International journal of molecular medicine 2006;18(4):625-32.
2006: Huanjie Yang; Di Chen; Qiuzhi Cindy Cui; Xiao Yuan; Qingping Dou
Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice.
Cancer research 2006;66(9):4758-65.
2006: Kristin R Landis-Piwowar; Di Chen; Qiuzhi Cindy Cui; Vesna Minic; Frederick F Becker; Bimal K Banik; Qingping Dou
Apoptotic-inducing activity of novel polycyclic aromatic compounds in human leukemic cells.
International journal of molecular medicine 2006;17(5):931-5.
2005: Di Chen; Kenyon G Daniel; Marina S Chen; Deborah J. Kuhn; Kristin R Landis-Piwowar; Qingping Dou
Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells.
Biochemical pharmacology 2005;69(10):1421-32.
2005: Kristin R Landis-Piwowar; Deborah J. Kuhn; Sheng Biao Wan; Di Chen; Tak Hang Chan; Qingping Dou
Evaluation of proteasome-inhibitory and apoptosis-inducing potencies of novel (-)-EGCG analogs and their prodrugs.
International journal of molecular medicine 2005;15(4):735-42.
2005: Sheng Biao Wan; Kristin R Landis-Piwowar; Deborah J. Kuhn; Di Chen; Qingping Dou; Tak Hang Chan
Structure-activity study of epi-gallocatechin gallate (EGCG) analogs as proteasome inhibitors.
Bioorganic & medicinal chemistry 2005;13(6):2177-85.
2005: Kenyon G Daniel; Di Chen; Shirley Orlu; Qiuzhi Cindy Cui; Fred R Miller; Qingping Dou
Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells.
Breast cancer research : BCR 2005;7(6):R897-908.
2005: Di Chen; Fangyu Peng; Qiuzhi Cindy Cui; Kenyon G Daniel; Shirley Orlu; Jianguo Liu; Qingping Dou
Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis.
Frontiers in bioscience : a journal and virtual library 2005;10():2932-9.
2005: Deborah J. Kuhn; Yang Wang; Vesna Minic; Cristina Coates; G Suresh Kumar Reddy; Kenyon G Daniel; Jeung-Yeop Shim; Di Chen; Kristin R Landis-Piwowar; Fred R Miller; Edward Turos; Qingping Dou
Structure-activity relationships OF N-methylthiolated beta-lactam antibiotics with C3 substitutions and their selective induction of apoptosis in human cancer cells.
Frontiers in bioscience : a journal and virtual library 2005;10():1183-90.
2004: Di Chen; Kenyon G Daniel; Deborah J. Kuhn; Aslamuzzaman Kazi; Mohammad Bhuiyan; Lianhai Li; Zhigang Wang; Sheng Biao Wan; Wai Har Lam; Tak Hang Chan; Qingping Dou
Green tea and tea polyphenols in cancer prevention.
Frontiers in bioscience : a journal and virtual library 2004;9():2618-31.
2004: Deborah J. Kuhn; Cristina Coates; Kenyon G Daniel; Di Chen; Mohammad Bhuiyan; Aslamuzzaman Kazi; Edward Turos; Qingping Dou
Beta-lactams and their potential use as novel anticancer chemotherapeutics drugs.
Frontiers in bioscience : a journal and virtual library 2004;9():2605-17.
2004: Sheng Biao Wan; Di Chen; Qingping Dou; Tak Hang Chan
Study of the green tea polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors.
Bioorganic & medicinal chemistry 2004;12(13):3521-7.
2004: Marina S Chen; Di Chen; Qingping Dou
Inhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death.
In vivo (Athens, Greece) 2004;18(1):73-80.