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Maria Margarida Bernardo

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Chemicals & Drugs

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Hsueh-Liang Fu; Malika Kumarasiri; Kiran V Mahasenan; Shahriar Mobashery; anjum sohail; Dorota Tokmina-Roszyk; Rajeshwari R Valiathan; Benjamin D Wasinski; Maria Margarida Bernardo; Gregg B Fields; Rafael Fridman
Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases.
Alexander Kaplun; Maria Margarida Bernardo; Sijana Dzinic; Shijie Sheng
Tumor suppressor maspin as a rheostat in HDAC regulation to achieve the fine-tuning of epithelial homeostasis.
Maria Margarida Bernardo; R Daniel Bonfil; Michael L Cher; Ivory Dean; Alan Anthony Dombkowski; Gregory Dyson; Sijana Dzinic; Alexander Kaplun; David Krass; Xiaohua Li; Jaron Lockett; Yonghong Meng; Kamiar Moin; Mary Olive; Wael A Sakr; Shuping Yin; Shijie Sheng
Maspin reprograms the gene expression profile of prostate carcinoma cells for differentiation.

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2013: Hsueh-Liang Fu; Malika Kumarasiri; Kiran V Mahasenan; Shahriar Mobashery; anjum sohail; Dorota Tokmina-Roszyk; Rajeshwari R Valiathan; Benjamin D Wasinski; Maria Margarida Bernardo; Gregg B Fields; Rafael Fridman
Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases.
The Journal of biological chemistry 2013;288(17):12114-29.
2012: Alexander Kaplun; Maria Margarida Bernardo; Sijana Dzinic; Shijie Sheng
Tumor suppressor maspin as a rheostat in HDAC regulation to achieve the fine-tuning of epithelial homeostasis.
Critical reviews in eukaryotic gene expression 2012;22(3):249-58.
2011: Maria Margarida Bernardo; R Daniel Bonfil; Michael L Cher; Ivory Dean; Alan Anthony Dombkowski; Gregory Dyson; Sijana Dzinic; Alexander Kaplun; David Krass; Xiaohua Li; Jaron Lockett; Yonghong Meng; Kamiar Moin; Mary Olive; Wael A Sakr; Shuping Yin; Shijie Sheng
Maspin reprograms the gene expression profile of prostate carcinoma cells for differentiation.
Genes & cancer 2011;2(11):1009-22.
2010: Essa Mayyas; Maria Margarida Bernardo; Lindsay Runyan; anjum sohail; Venkatesh Subba-Rao; MA Pantea; Rafael Fridman; Peter Manfred Hoffmann
Dissociation kinetics of an enzyme-inhibitor system using single-molecule force measurements.
Biomacromolecules 2010;11(12):3352-8.
2009: Mijoon Lee; giuseppe celenza; Bill Boggess; Jennifer Blase; Qicun Shi; Marta Toth; Maria Margarida Bernardo; William R Wolter; Mark A Suckow; Dusan Hesek; Bruce C Noll; Rafael Fridman; Shahriar Mobashery; Mayland Chang
A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition.
Chemical biology & drug design 2009;73(2):189-202.
2008: anjum sohail; Qing Sun; Huiren Zhao; Maria Margarida Bernardo; Jin-Ah Cho; Rafael Fridman
MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer.
Cancer metastasis reviews 2008;27(2):289-302.
2007: Qing Sun; Christopher R Weber; anjum sohail; Maria Margarida Bernardo; Marta Toth; Huiren Zhao; Jerrold R Turner; Rafael Fridman
MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties.
The Journal of biological chemistry 2007;282(30):21998-2010.
2006: R Daniel Bonfil; Aaron Sabbota; Sanaa M Nabha; Maria Margarida Bernardo; Zhong Dong; Hong Meng; Hamilto Yamamoto; Sreenivasa R Chinni; In Taek Lim; Mayland Chang; Lusia C Filetti; Shahriar Mobashery; Michael L Cher; Rafael Fridman
Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor.
International journal of cancer. Journal international du cancer 2006;118(11):2721-6.
2005: Masahiro Ikejiri; Maria Margarida Bernardo; R Daniel Bonfil; Marta Toth; Mayland Chang; Rafael Fridman; Shahriar Mobashery
Potent mechanism-based inhibitors for matrix metalloproteinases.
The Journal of biological chemistry 2005;280(40):33992-4002.
2005: Mijoon Lee; Maria Margarida Bernardo; Samy O Meroueh; Stephen Brown; Rafael Fridman; Shahriar Mobashery
Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors.
Organic letters 2005;7(20):4463-5.
2005: Masahiro Ikejiri; Maria Margarida Bernardo; Samy O Meroueh; Stephen Brown; Mayland Chang; Rafael Fridman; Shahriar Mobashery
Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A.
The Journal of organic chemistry 2005;70(14):5709-12.
2005: Achim Krüger; Matthias J E Arlt; Michael Gerg; Charlotte Kopitz; Maria Margarida Bernardo; Mayland Chang; Shahriar Mobashery; Rafael Fridman
Antimetastatic activity of a novel mechanism-based gelatinase inhibitor.
Cancer research 2005;65(9):3523-6.
2005: Zhong Dong; R Daniel Bonfil; Sreenivasa R Chinni; Xiyun Deng; J Carlos Trindade Filho; Maria Margarida Bernardo; Ulka Nitin Vaishampayan; Mingxin Che; Bonnie F Sloane; Shijie Sheng; Rafael Fridman; Michael L Cher
Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue.
The American journal of pathology 2005;166(4):1173-86.
2004: Huiren Zhao; Maria Margarida Bernardo; Pamela Osenkowski; anjum sohail; Duanqing Pei; Hideaki Nagase; Masahide Kashiwagi; Paul D Soloway; Yves A DeClerck; Rafael Fridman
Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation.
The Journal of biological chemistry 2004;279(10):8592-601.
2003: Xu-Wen Liu; Maria Margarida Bernardo; Rafael Fridman; Hyeong-Reh Choi Kim
Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/phosphatidylinositol 3-kinase and MAPK signaling pathway.
The Journal of biological chemistry 2003;278(41):40364-72.
2003: Maria Margarida Bernardo; Rafael Fridman
TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP.
The Biochemical journal 2003;374(Pt 3):739-45.
2003: Marta Toth; Irina Chvyrkova; Maria Margarida Bernardo; Sonia Hernandez-Barrantes; Rafael Fridman
Pro-MMP-9 activation by the MT1-MMP/MMP-2 axis and MMP-3: role of TIMP-2 and plasma membranes.
Biochemical and biophysical research communications 2003;308(2):386-95.
2002: Marta Toth; Sonia Hernandez-Barrantes; Pamela Osenkowski; Maria Margarida Bernardo; David C Gervasi; Yoichiro Shimura; Oussama Meroueh; Lakshmi P Kotra; Beatriz G Gálvez; Alicia G Arroyo; Shahriar Mobashery; Rafael Fridman
Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme.
The Journal of biological chemistry 2002;277(29):26340-50.
2002: Sonia Hernandez-Barrantes; Maria Margarida Bernardo; Marta Toth; Rafael Fridman
Regulation of membrane type-matrix metalloproteinases.
Seminars in cancer biology 2002;12(2):131-8.
2002: Maria Margarida Bernardo; Stephen Brown; Zhi-Hong Li; Rafael Fridman; Shahriar Mobashery
Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases.
The Journal of biological chemistry 2002;277(13):11201-7.
2001: Oded Kleifeld; Lakshmi P Kotra; David C Gervasi; Stephen Brown; Maria Margarida Bernardo; Rafael Fridman; Shahriar Mobashery; Irit Sagi
X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme.
The Journal of biological chemistry 2001;276(20):17125-31.
2000: Marta Toth; Maria Margarida Bernardo; David C Gervasi; Paul D Soloway; Zhijian Wang; Heather F Bigg; Christopher M Overall; Yves A DeClerck; H Tschesche; Michael L Cher; Stephen Brown; Shahriar Mobashery; Rafael Fridman
Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.
The Journal of biological chemistry 2000;275(52):41415-23.
2000: Sonia Hernandez-Barrantes; Marta Toth; Maria Margarida Bernardo; M Yurkova; David C Gervasi; Y Raz; Q A Sang; Rafael Fridman
Binding of active (57 kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 activation.
The Journal of biological chemistry 2000;275(16):12080-9.
2000: MW Olson; Maria Margarida Bernardo; M Pietila; David C Gervasi; Marta Toth; Lakshmi P Kotra; I Massova; Shahriar Mobashery; Rafael Fridman
Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. Differential rates for activation by stromelysin 1.
The Journal of biological chemistry 2000;275(4):2661-8.
1996: Paul E Bock; D E Day; Ingrid Verhamme; Maria Margarida Bernardo; Steven T Olson; Joseph D Shore
Analogs of human plasminogen that are labeled with fluorescence probes at the catalytic site of the zymogen. Preparation, characterization, and interaction with streptokinase.
The Journal of biological chemistry 1996;271(2):1072-80.
1993: Maria Margarida Bernardo; D E Day; H R Halvorson; Steven T Olson; Joseph D Shore
Surface-independent acceleration of factor XII activation by zinc ions. II. Direct binding and fluorescence studies.
The Journal of biological chemistry 1993;268(17):12477-83.
1993: Maria Margarida Bernardo; D E Day; Steven T Olson; Joseph D Shore
Surface-independent acceleration of factor XII activation by zinc ions. I. Kinetic characterization of the metal ion rate enhancement.
The Journal of biological chemistry 1993;268(17):12468-76.
1986: Hanley N Abramson; J W Banning; J P Nachtman; E T Roginski; M Sardessai; Henry C Wormser; J D Wu; Z Nagia; R R Schroeder; Maria Margarida Bernardo
Synthesis of anthraquinonyl glucosaminosides and studies on the influence of aglycone hydroxyl substitution on superoxide generation, DNA binding, and antimicrobial properties.
Journal of medicinal chemistry 1986;29(9):1709-14.