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Thomas Harris
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55
Harris, Constance
42
Stone, Michael
35
Lloyd, Stephen
24
Nechev, Lubomir
18
Rizzo, Carmelo
18
Kozekov, Ivan
17
Guengerich, Peter
12
Tamura, Pamela
9
Raney, Kevin
9
Kim, Hye-Young
8
Wang, Hao
8
Minko, Irina
7
Merritt, Keither
7
Kozekova, Albena
7
Brash, Alan
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All Publications
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2009: Huang Hai; Kim Hye-Young; Kozekov Ivan D; Cho Young-Jin; Wang Hao; Kozekova Albena; Harris Thomas M; Rizzo Carmelo J; Stone Michael P
Stereospecific formation of the (R)-gamma-hydroxytrimethylene interstrand N2-dG:N2-dG cross-link arising from the gamma-OH-1,N2-propano-2'-deoxyguanosine adduct in the 5'-CpG-3' DNA sequence.
Journal of the American Chemical Society 2009;131(24):8416-24.
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2008: Christov Plamen P; Brown Kyle L; Kozekov Ivan D; Stone Michael P; Harris Thomas M; Rizzo Carmelo J
Site-specific synthesis and characterization of oligonucleotides containing an N6-(2-deoxy-D-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine lesion, the ring-opened product from N7-methylation of deoxyguanosine.
Chemical research in toxicology 2008;21(12):2324-33.
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2008: VanderVeen Laurie A; Harris Thomas M; Jen-Jacobson Linda; Marnett Lawrence J
Formation of DNA-protein cross-links between gamma-hydroxypropanodeoxyguanosine and EcoRI.
Chemical research in toxicology 2008;21(9):1733-8.
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2008: Christov Plamen P; Kozekov Ivan D; Rizzo Carmelo J; Harris Thomas M
The formamidopyrimidine derivative of 7-(2-oxoethyl)-2'-deoxyguanosine.
Chemical research in toxicology 2008;21(9):1777-86.
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2008: Stone Michael P; Cho Young-Jin; Huang Hai; Kim Hye-Young; Kozekov Ivan D; Kozekova Albena; Wang Hao; Minko Irina G; Lloyd R Stephen; Harris Thomas M; Rizzo Carmelo J
Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources.
Accounts of chemical research 2008;41(7):793-804.
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2008: Minko Irina G; Harbut Michael B; Kozekov Ivan D; Kozekova Albena; Jakobs Petra M; Olson Susan B; Moses Robb E; Harris Thomas M; Rizzo Carmelo J; Lloyd R Stephen
Role for DNA polymerase kappa in the processing of N2-N2-guanine interstrand cross-links.
The Journal of biological chemistry 2008;283(25):17075-82.
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2008: Minko Irina G; Kozekov Ivan D; Kozekova Albena; Harris Thomas M; Rizzo Carmelo J; Lloyd R Stephen
Mutagenic potential of DNA-peptide crosslinks mediated by acrolein-derived DNA adducts.
Mutation research 2008;637(1-2):161-72.
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2007: Cho Young-Jin; Kozekov Ivan D; Harris Thomas M; Rizzo Carmelo J; Stone Michael P
Stereochemistry modulates the stability of reduced interstrand cross-links arising from R- and S-alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine in the 5'-CpG-3' DNA sequence.
Biochemistry 2007;46(10):2608-21.
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2007: Xu Wen; Merritt W Keither; Nechev Lubomir V; Harris Thomas M; Harris Constance M; Lloyd R Stephen; Stone Michael P
Structure of the 1,4-Bis(2'-deoxyadenosin-N(6)-yl)-2S,3S-butanediol intrastrand DNA cross-link arising from butadiene diepoxide in the human N-ras codon 61 sequence.
Chemical research in toxicology 2007;20(2):187-98.
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2006: Brown Kyle L; Deng James Z; Iyer Rajkumar S; Iyer Lalitha G; Voehler Markus W; Stone Michael P; Harris Constance M; Harris Thomas M
Unraveling the aflatoxin-FAPY conundrum: structural basis for differential replicative processing of isomeric forms of the formamidopyrimidine-type DNA adduct of aflatoxin B1.
Journal of the American Chemical Society 2006;128(47):15188-99.
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2006: Wang Hao; Kozekov Ivan D; Kozekova Albena; Tamura Pamela J; Marnett Lawrence J; Harris Thomas M; Rizzo Carmelo J
Site-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a postsynthetic modification strategy.
Chemical research in toxicology 2006;19(11):1467-74.
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2006: Cho Young-Jin; Wang Hao; Kozekov Ivan D; Kozekova Albena; Kurtz Andrew J; Jacob Jaison; Voehler Markus; Smith Jarrod; Harris Thomas M; Rizzo Carmelo J; Lloyd R Stephen; Stone Michael P
Orientation of the crotonaldehyde-derived N2-[3-Oxo-1(S)-methyl-propyl]-dG DNA adduct hinders interstrand cross-link formation in the 5'-CpG-3' sequence.
Chemical research in toxicology 2006;19(8):1019-29.
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2006: Zang Hong; Chowdhury Goutam; Angel Karen C; Harris Thomas M; Guengerich F Peter
Translesion synthesis across polycyclic aromatic hydrocarbon diol epoxide adducts of deoxyadenosine by Sulfolobus solfataricus DNA polymerase Dpo4.
Chemical research in toxicology 2006;19(6):859-67.
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2006: Cho Young-Jin; Wang Hao; Kozekov Ivan D; Kurtz Andrew J; Jacob Jaison; Voehler Markus; Smith Jarrod; Harris Thomas M; Lloyd R Stephen; Rizzo Carmelo J; Stone Michael P
Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence.
Chemical research in toxicology 2006;19(2):195-208.
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2005: Cho Young-Jin; Kim Hye-Young; Huang Hai; Slutsky Alvira; Minko Irina G; Wang Hao; Nechev Lubomir V; Kozekov Ivan D; Kozekova Albena; Tamura Pamela; Jacob Jaison; Voehler Markus; Harris Thomas M; Lloyd R Stephen; Rizzo Carmelo J; Stone Michael P
Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 5'-CpG-3' sequence by the acrolein-derived gamma-OH-1,N2-propano-2'-deoxyguanosine DNA adduct.
Journal of the American Chemical Society 2005;127(50):17686-96.
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2005: Kanuri Manorama; Nechev Lubomir V; Kiehna Sarah E; Tamura Pamela J; Harris Constance M; Harris Thomas M; Lloyd R Stephen
Evidence for Escherichia coli polymerase II mutagenic bypass of intrastrand DNA crosslinks.
DNA repair 2005;4(12):1374-80.
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2005: Goodenough Angela K; Kozekov Ivan D; Zang Hong; Choi Jeong-Yun; Guengerich F Peter; Harris Thomas M; Rizzo Carmelo J
Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine.
Chemical research in toxicology 2005;18(11):1701-14.
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2005: Sanchez Ana M; Kozekov Ivan D; Harris Thomas M; Lloyd R Stephen
Formation of inter- and intrastrand imine type DNA-DNA cross-links through secondary reactions of aldehydic adducts.
Chemical research in toxicology 2005;18(11):1683-90.
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2005: Merritt W Keither; Nechev Lubomir V; Scholdberg Tandace A; Dean Stephen M; Kiehna Sarah E; Chang Johanna C; Harris Thomas M; Harris Constance M; Lloyd R Stephen; Stone Michael P
Structure of the 1,4-bis(2'-deoxyadenosin-N6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide.
Biochemistry 2005;44(30):10081-92.
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2005: Merritt W Keither; Kowalczyk Agnieszka; Scholdberg Tandace A; Dean Stephen M; Harris Thomas M; Harris Constance M; Lloyd R Stephen; Stone Michael P
Dual roles of glycosyl torsion angle conformation and stereochemical configuration in butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adducts: a structural perspective.
Chemical research in toxicology 2005;18(7):1098-107.
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2005: Fernandes Priscilla H; Kanuri Manorama; Nechev Lubomir V; Harris Thomas M; Lloyd R Stephen
Mammalian cell mutagenesis of the DNA adducts of vinyl chloride and crotonaldehyde.
Environmental and molecular mutagenesis 2005;45(5):455-9.
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2005: Scholdberg Tandace A; Merritt W Keither; Dean Stephen M; Kowalcyzk Agnieska; Harris Constance M; Harris Thomas M; Rizzo Carmelo J; Lloyd R Stephen; Stone Michael P
Structure of an oligodeoxynucleotide containing a butadiene oxide-derived N1 beta-hydroxyalkyl deoxyinosine adduct in the human N-ras codon 61 sequence.
Biochemistry 2005;44(9):3327-37.
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2005: Minko Irina G; Kurtz Andrew J; Croteau Deborah L; Van Houten Bennett; Harris Thomas M; Lloyd R Stephen
Initiation of repair of DNA-polypeptide cross-links by the UvrABC nuclease.
Biochemistry 2005;44(8):3000-9.
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2005: Zang Hong; Harris Thomas M; Guengerich F Peter
Kinetics of nucleotide incorporation opposite polycyclic aromatic hydrocarbon-DNA adducts by processive bacteriophage T7 DNA polymerase.
Chemical research in toxicology 2005;18(2):389-400.
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2005: Scholdberg Tandace A; Nechev Lubomir V; Merritt W Keither; Harris Thomas M; Harris Constance M; Lloyd R Stephen; Stone Michael P
Mispairing of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA Adduct of butadiene diol epoxide with deoxyguanosine: formation of a dA(anti).dG(anti) pairing interaction.
Chemical research in toxicology 2005;18(2):145-53.
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2005: Zang Hong; Harris Thomas M; Guengerich F Peter
Kinetics of nucleotide incorporation opposite DNA bulky guanine N2 adducts by processive bacteriophage T7 DNA polymerase (exonuclease-) and HIV-1 reverse transcriptase.
The Journal of biological chemistry 2005;280(2):1165-78.
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2004: Brock Angela K; Kozekov Ivan D; Rizzo Carmelo J; Harris Thomas M
Coupling products of nucleosides with the glyoxal adduct of deoxyguanosine.
Chemical research in toxicology 2004;17(8):1047-56.
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2004: Merritt W Keither; Scholdberg Tandace A; Nechev Lubomir V; Harris Thomas M; Harris Constance M; Lloyd R Stephen; Stone Michael P
Stereospecific structural perturbations arising from adenine N(6) butadiene triol adducts in duplex DNA.
Chemical research in toxicology 2004;17(8):1007-19.
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2004: Washington M Todd; Minko Irina G; Johnson Robert E; Haracska Lajos; Harris Thomas M; Lloyd R Stephen; Prakash Satya; Prakash Louise
Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta.
Molecular and cellular biology 2004;24(16):6900-6.
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2004: Washington M Todd; Minko Irina G; Johnson Robert E; Wolfle William T; Harris Thomas M; Lloyd R Stephen; Prakash Satya; Prakash Louise
Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa.
Molecular and cellular biology 2004;24(13):5687-93.
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2004: Scholdberg Tandace A; Nechev Lubomir V; Merritt W Keither; Harris Thomas M; Harris Constance M; Lloyd R Stephen; Stone Michael P
Structure of a site specific major groove (2S,3S)-N6-(2,3,4-trihydroxybutyl)-2'-deoxyadenosyl DNA adduct of butadiene diol epoxide.
Chemical research in toxicology 2004;17(6):717-30.
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2004: Wang Hao; Marnett Lawrence J; Harris Thomas M; Rizzo Carmelo J
A novel synthesis of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine.
Chemical research in toxicology 2004;17(2):144-9.
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2003: Wang Hao; Kozekov Ivan D; Harris Thomas M; Rizzo Carmelo J
Site-specific synthesis and reactivity of oligonucleotides containing stereochemically defined 1,N2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal.
Journal of the American Chemical Society 2003;125(19):5687-700.
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2003: Kim Hye-Young H; Wilkinson Amanda S; Harris Constance M; Harris Thomas M; Stone Michael P
Minor groove orientation for the (1S,2R,3S,4R)-N2- [1-(1,2,3,4-tetrahydro-2,3,4-trihydroxybenz[a]anthracenyl)]-2'-deoxyguanosyl adduct in the N-ras codon 12 sequence.
Biochemistry 2003;42(8):2328-38.
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2003: Dooley Patricia A; Zhang Mingzhou; Korbel Gregory A; Nechev Lubomir V; Harris Constance M; Stone Michael P; Harris Thomas M
NMR determination of the conformation of a trimethylene interstrand cross-link in an oligodeoxynucleotide duplex containing a 5'-d(GpC) motif.
Journal of the American Chemical Society 2003;125(1):62-72.
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2003: Kozekov Ivan D; Nechev Lubomir V; Moseley M Scott; Harris Constance M; Rizzo Carmelo J; Stone Michael P; Harris Thomas M
DNA interchain cross-links formed by acrolein and crotonaldehyde.
Journal of the American Chemical Society 2003;125(1):50-61.
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2002: Kanuri Manorama; Nechev Lubomir V; Tamura Pamela J; Harris Constance M; Harris Thomas M; Lloyd R Stephen
Mutagenic spectrum of butadiene-derived N1-deoxyinosine adducts and N6,N6-deoxyadenosine intrastrand cross-links in mammalian cells.
Chemical research in toxicology 2002;15(12):1572-80.
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2002: Kim Hye-Young H; Voehler Markus; Harris Thomas M; Stone Michael P
Detection of an interchain carbinolamine cross-link formed in a CpG sequence by the acrolein DNA adduct gamma-OH-1,N( 2)-propano-2'-deoxyguanosine.
Journal of the American Chemical Society 2002;124(32):9324-5.
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2002: Guengerich F Peter; Voehler Markus; Williams Kevin M; Deng Zhengwu; Harris Thomas M
Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine.
Chemical research in toxicology 2002;15(6):793-8.
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2002: Guengerich F Peter; Arneson Kyle O; Williams Kevin M; Deng Zhengwu; Harris Thomas M
Reaction of aflatoxin B(1) oxidation products with lysine.
Chemical research in toxicology 2002;15(6):780-92.
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2002: Nechev Lubomir V; Kozekov Ivan D; Brock Angela K; Rizzo Carmelo J; Harris Thomas M
DNA adducts of acrolein: site-specific synthesis of an oligodeoxynucleotide containing 6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one, an acrolein adduct of guanine.
Chemical research in toxicology 2002;15(5):607-13.
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2002: Smela Maryann E; Hamm Michelle L; Henderson Paul T; Harris Constance M; Harris Thomas M; Essigmann John M
The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(10):6655-60.
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2002: Kanuri Manorama; Minko Irina G; Nechev Lubomir V; Harris Thomas M; Harris Constance M; Lloyd R Stephen
Error prone translesion synthesis past gamma-hydroxypropano deoxyguanosine, the primary acrolein-derived adduct in mammalian cells.
The Journal of biological chemistry 2002;277(21):18257-65.
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2002: Kowalczyk Agnieszka; Carmical J Russ; Zou Yue; Van Houten Bennett; Lloyd R Stephen; Harris Constance M; Harris Thomas M
Intrastrand DNA cross-links as tools for studying DNA replication and repair: two-, three-, and four-carbon tethers between the N(2) positions of adjacent guanines.
Biochemistry 2002;41(9):3109-18.
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2001: Nechev L V; Kozekov I; Harris C M; Harris T M
Stereospecific synthesis of oligonucleotides containing crotonaldehyde adducts of deoxyguanosine.
Chemical research in toxicology 2001;14(11):1506-12.
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2001: Kozekov I D; Nechev L V; Sanchez A; Harris C M; Lloyd R S; Harris T M
Interchain cross-linking of DNA mediated by the principal adduct of acrolein.
Chemical research in toxicology 2001;14(11):1482-5.
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2001: Kim H Y; Cooper M; Nechev L V; Harris C M; Harris T M
Synthesis and characterization of nucleosides and oligonucleotides with a benzo[a]pyren-6-ylmethyl adduct at adenine N6 or guanine N2.
Chemical research in toxicology 2001;14(9):1306-14.
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2001: Hennard C; Finneman J; Harris C M; Harris T M; Stone M P
The nonmutagenic (R)- and (S)-beta-(N(6)-adenyl)styrene oxide adducts are oriented in the major groove and show little perturbation to DNA structure.
Biochemistry 2001;40(33):9780-91.
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2001: Kowalczyk A; Harris C M; Harris T M
Synthesis and characterization of oligodeoxynucleotides containing an N1 beta-hydroxyalkyl adduct of 2'-deoxyinosine.
Chemical research in toxicology 2001;14(6):746-53.
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2001: Guengerich F P; Cai H; McMahon M; Hayes J D; Sutter T R; Groopman J D; Deng Z; Harris T M
Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.
Chemical research in toxicology 2001;14(6):727-37.
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2001: Li Z; Tamura P J; Wilkinson A S; Harris C M; Harris T M; Stone M P
Intercalation of the (1R,2S,3R,4S)-N6-[1-(1,2,3,4-tetrahydro-2,3,4-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence: DNA sequence effects.
Biochemistry 2001;40(23):6743-55.
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2001: Harris T M; Harris C M
Synthesis of N2-substituted deoxyguanosine nucleosides from 2-fluoro-6-O-(trimethylsilylethyl)-2'-deoxyinosine.
Current protocols in nucleic acid chemistry / edited by Serge L. Beaucage ... [et al.] 2001;Chapter 1():Unit 1.3.
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2001: Nechev L V; Zhang M; Tsarouhtsis D; Tamura P J; Wilkinson A S; Harris C M; Harris T M
Synthesis and characterization of nucleosides and oligonucleotides bearing adducts of butadiene epoxides on adenine n(6) and guanine n(2).
Chemical research in toxicology 2001;14(4):379-88.
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2001: VanderVeen L A; Hashim M F; Nechev L V; Harris T M; Harris C M; Marnett L J
Evaluation of the mutagenic potential of the principal DNA adduct of acrolein.
The Journal of biological chemistry 2001;276(12):9066-70.
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2001: Dooley P A; Tsarouhtsis D; Korbel G A; Nechev L V; Shearer J; Zegar I S; Harris C M; Stone M P; Harris T M
Structural studies of an oligodeoxynucleotide containing a trimethylene interstrand cross-link in a 5'-(CpG) motif: model of a malondialdehyde cross-link.
Journal of the American Chemical Society 2001;123(8):1730-9.
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2001: Kanuri M; Finneman J; Harris C M; Harris T M; Lloyd R S
Efficient nonmutagenic replication bypass of DNAs containing beta-adducts of styrene oxide at adenine N(6).
Environmental and molecular mutagenesis 2001;38(4):357-60.
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2001: Rodriguez D A; Kowalczyk A; Ward J B; Harris C M; Harris T M; Lloyd R S
Point mutations induced by 1,2-epoxy-3-butene N1 deoxyinosine adducts.
Environmental and molecular mutagenesis 2001;38(4):292-6.
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2000: Kim H Y; Finneman J I; Harris C M; Harris T M
Studies of the mechanisms of adduction of 2'-deoxyadenosine with styrene oxide and polycyclic aromatic hydrocarbon dihydrodiol epoxides.
Chemical research in toxicology 2000;13(7):625-37.
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2000: Carmical J R; Kowalczyk A; Zou Y; Van Houten B; Nechev L V; Harris C M; Harris T M; Lloyd R S
Butadiene-induced intrastrand DNA cross-links: a possible role in deletion mutagenesis.
The Journal of biological chemistry 2000;275(26):19482-9.
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2000: Nechev L V; Harris C M; Harris T M
Synthesis of nucleosides and oligonucleotides containing adducts of acrolein and vinyl chloride.
Chemical research in toxicology 2000;13(5):421-9.
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2000: Mu D; Bessho T; Nechev L V; Chen D J; Harris T M; Hearst J E; Sancar A
DNA interstrand cross-links induce futile repair synthesis in mammalian cell extracts.
Molecular and cellular biology 2000;20(7):2446-54.
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2000: Le P T; Harris C M; Harris T M; Stone M P
Altered electrophoretic migration of polycyclic aromatic hydrocarbon and styrene oxide adducts at adenine N(6) correlates with adduct-induced structural disorder.
Chemical research in toxicology 2000;13(2):63-71.
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2000: Simeonov M F; Tamura P J; Wilkinson A S; Harris C M; Harris T M; Stone M P
Sequence- and stereospecific conformational rearrangement of styrene oxide adducts located at A x C mismatched base pairs.
Biochemistry 2000;39(5):924-37.
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2000: Carmical J R; Zhang M; Nechev L; Harris C M; Harris T M; Lloyd R S
Mutagenic potential of guanine N2 adducts of butadiene mono- and diolepoxide.
Chemical research in toxicology 2000;13(1):18-25.
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2000: Carmical J R; Nechev L V; Harris C M; Harris T M; Lloyd R S
Mutagenic potential of adenine N(6) adducts of monoepoxide and diolepoxide derivatives of butadiene.
Environmental and molecular mutagenesis 2000;35(1):48-56.
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1999: Li Z; Kim H Y; Tamura P J; Harris C M; Harris T M; Stone M P
Intercalation of the (1S,2R,3S,4R)-N6-[1-(1,2,3,4-tetrahydro-2,3, 4-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in an oligodeoxynucleotide containing the human N-ras codon 61 sequence.
Biochemistry 1999;38(49):16045-57.
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1999: Li Z; Kim H Y; Tamura P J; Harris C M; Harris T M; Stone M P
Role of a polycyclic aromatic hydrocarbon bay region ring in modulating DNA adduct structure: the non-bay region (8S,9R,10S, 11R)-N(6)-[11-(8,9,10,11-tetrahydro-8,9, 10-trihydroxybenz[a]anthracenyl)]-2'-deoxyadenosyl adduct in codon 61 of the human N-ras protooncogene.
Biochemistry 1999;38(45):14820-32.
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1999: Gurvich V; Kim H Y; Hodge R P; Harris C M; Harris T M
Utilization of tetrabutylammonium triphenyldifluorosilicate (TBAT) in the synthesis of 6-fluoropurine nucleosides.
Nucleosides & nucleotides 1999;18(10):2327-33.
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1999: Painter S L; Zegar I S; Tamura P J; Bluhm S; Harris C M; Harris T M; Stone M P
Influence of the R(61,2)- and S(61,2)-alpha-(N6-adenyl)styrene oxide adducts on the A.C mismatched base pair in an oligodeoxynucleotide containing the human N-ras codon 61.
Biochemistry 1999;38(27):8635-46.
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1999: Li Z; Mao H; Kim H Y; Tamura P J; Harris C M; Harris T M; Stone M P
Intercalation of the (-)-(1R,2S,3R, 4S)-N6-[1-benz[a]anthracenyl]-2'-deoxyadenosyl adduct in an oligodeoxynucleotide containing the human N-ras codon 61 sequence.
Biochemistry 1999;38(10):2969-81.
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1998: Zegar I S; Chary P; Jabil R J; Tamura P J; Johansen T N; Lloyd R S; Harris C M; Harris T M; Stone M P
Multiple conformations of an intercalated (-)-(7S,8R,9S, 10R)-N6-[10-(7,8,9,10-tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct in the N-ras codon 61 sequence.
Biochemistry 1998;37(47):16516-28.
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1998: Setayesh F R; DeCorte B L; Horton P; Harris C M; Harris T M; Stone M P
Styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 12: minor groove structures of the R(12,1)- and S(12,1)-alpha-(N2-guanyl) stereoisomers determined by 1H nuclear magnetic resonance.
Chemical research in toxicology 1998;11(7):766-77.
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1998: Remington K M; Bennett S E; Harris C M; Harris T M; Bebenek K
Highly mutagenic bypass synthesis by T7 RNA polymerase of site-specific benzo[a]pyrene diol epoxide-adducted template DNA.
The Journal of biological chemistry 1998;273(21):13170-6.
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1998: Mao H; Deng Z; Wang F; Harris T M; Stone M P
An intercalated and thermally stable FAPY adduct of aflatoxin B1 in a DNA duplex: structural refinement from 1H NMR.
Biochemistry 1998;37(13):4374-87.
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1997: McNees A G; O'Donnell M; Horton P H; Kim H Y; Kim S J; Harris C M; Harris T M; Lloyd R S
Lack of correlation between in vitro and in vivo replication of precisely defined benz-a-anthracene adducted DNAs.
The Journal of biological chemistry 1997;272(52):33211-9.
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1997: Hsu C H; Skipper P L; Harris T M; Tannenbaum S R
Characterization of DNA adducts formed by cyclopenta[cd]pyrene epoxide.
Chemical research in toxicology 1997;10(2):248-53.
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1997: Chary P; Harris C M; Harris T M; Lloyd R S
Differential tolerance to DNA polymerization by HIV-1 reverse transcriptase on N6 adenine C10R and C10S benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide-adducted templates.
The Journal of biological chemistry 1997;272(9):5805-13.
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1996: Latham G J; McNees A G; De Corte B; Harris C M; Harris T M; O'Donnell M; Lloyd R S
Comparison of the efficiency of synthesis past single bulky DNA adducts in vivo and in vitro by the polymerase III holoenzyme.
Chemical research in toxicology 1996;9(7):1167-75.
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1996: Bailey E A; Iyer R S; Harris T M; Essigmann J M
A viral genome containing an unstable aflatoxin B1-N7-guanine DNA adduct situated at a unique site.
Nucleic acids research 1996;24(14):2821-8.
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1996: Feng B; Voehler M; Zhou L; Passarelli M; Harris C M; Harris T M; Stone M P
Major groove (S)-alpha-(N6-adenyl)styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 61 sequence: conformations of the S(61,2) and S(61,3) sequence isomers from 1H NMR.
Biochemistry 1996;35(23):7316-29.
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1996: Zegar I S; Kim S J; Johansen T N; Horton P J; Harris C M; Harris T M; Stone M P
Adduction of the human N-ras codon 61 sequence with (-)-(7S,8R,9R,10S)-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a] pyrene: structural refinement of the intercalated SRSR(61,2) (-)-(7S,8R,9S,10R)-N6-[10-(7,8,9,10- tetrahydrobenzo[a]pyrenyl)]-2'-deoxyadenosyl adduct from 1H NMR.
Biochemistry 1996;35(20):6212-24.
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1996: DeCorte B L; Tsarouhtsis D; Kuchimanchi S; Cooper M D; Horton P; Harris C M; Harris T M
Improved strategies for postoligomerization synthesis of oligodeoxynucleotides bearing structurally defined adducts at the N2 position of deoxyguanosine.
Chemical research in toxicology 1996;9(3):630-7.
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1996: Zegar I S; Setayesh F R; DeCorte B L; Harris C M; Harris T M; Stone M P
Styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 12 sequence: structural refinement of the minor groove R(12,2)- and S(12,2)-alpha-(N2-guanyl) stereoisomers from 1H NMR.
Biochemistry 1996;35(14):4334-48.
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1996: Bailey E A; Iyer R S; Stone M P; Harris T M; Essigmann J M
Mutational properties of the primary aflatoxin B1-DNA adduct.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1535-9.
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1996: Guengerich F P; Ueng Y F; Kim B R; Langouet S; Coles B; Iyer R S; Thier R; Harris T M; Shimada T; Yamazaki H; Ketterer B; Guillouzo A
Activation of toxic chemicals by cytochrome P450 enzymes: regio- and stereoselective oxidation of aflatoxin B1.
Advances in experimental medicine and biology 1996;387():7-15.
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1995: Feng B; Zhou L; Passarelli M; Harris C M; Harris T M; Stone M P
Major groove (R)-alpha-(N6-adenyl)styrene oxide adducts in an oligodeoxynucleotide containing the human N-ras codon 61 sequence: conformations of the R(61,2) and R(61,3) sequence isomers from 1H NMR.
Biochemistry 1995;34(43):14021-36.
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1995: Kim S J; Jajoo H K; Kim H Y; Zhou L; Horton P; Harris C M; Harris T M
An efficient route to N6 deoxyadenosine adducts of diol epoxides of carcinogenic polycyclic aromatic hydrocarbons.
Bioorganic & medicinal chemistry 1995;3(6):811-22.
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1995: Latham G J; Harris C M; Harris T M; Lloyd R S
The efficiency of translesion synthesis past single styrene oxide DNA adducts in vitro is polymerase-specific.
Chemical research in toxicology 1995;8(3):422-30.
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1995: Chary P; Latham G J; Robberson D L; Kim S J; Han S; Harris C M; Harris T M; Lloyd R S
In vivo and in vitro replication consequences of stereoisomeric benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide adducts on adenine N6 at the second position of N-ras codon 61.
The Journal of biological chemistry 1995;270(10):4990-5000.
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1994: Guengerich F P; Shimada T; Yun C H; Yamazaki H; Raney K D; Thier R; Coles B; Harris T M
Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes.
Environmental health perspectives 1994;102 Suppl 9():49-53.
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1994: Tamura M; Harris T M; Phillips D; Blair I A; Wang Y F; Hellerqvist C G; Lam S K; Inagami T
Identification of two cardiac glycosides as Na(+)-pump inhibitors in rat urine and diet.
The Journal of biological chemistry 1994;269(16):11972-9.
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1993: Latham G J; Zhou L; Harris C M; Harris T M; Lloyd R S
The replication fate of R- and S-styrene oxide adducts on adenine N6 is dependent on both the chirality of the lesion and the local sequence context.
The Journal of biological chemistry 1993;268(31):23427-34.
-
1993: Iyer R S; Harris T M
Preparation of aflatoxin B1 8,9-epoxide using m-chloroperbenzoic acid.
Chemical research in toxicology 1993;6(3):313-6.
-
1993: Song W C; Baertschi S W; Boeglin W E; Harris T M; Brash A R
Formation of epoxyalcohols by a purified allene oxide synthase. Implications for the mechanism of allene oxide synthesis.
The Journal of biological chemistry 1993;268(9):6293-8.
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1993: Raney V M; Harris T M; Stone M P
DNA conformation mediates aflatoxin B1-DNA binding and the formation of guanine N7 adducts by aflatoxin B1 8,9-exo-epoxide.
Chemical research in toxicology 1993;6(1):64-8.
-
1993: Tamura M; Harris T M; Konishi F; Inagami T
Isolation and characterization of an endogenous Na+,K(+)-ATPase-specific inhibitor from pig urine.
European journal of biochemistry / FEBS 1993;211(1-2):317-27.
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1993: Meyer D J; Coles B; Harris J; Gilmore K S; Raney K; Harris T M; Guengerich F P; Kensler T W; Ketterer B
Induction of rat liver GSH transferases by 1,2-dithiole-3-thione illustrates both anticarcinogenic and tumor-promoting properties.
Basic life sciences 1993;61():171-9.
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1992: Guengerich F P; Shimada T; Raney K D; Yun C H; Meyer D J; Ketterer B; Harris T M; Groopman J D; Kadlubar F F
Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology.
Environmental health perspectives 1992;98():75-80.
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1992: Raney K D; Meyer D J; Ketterer B; Harris T M; Guengerich F P
Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases.
Chemical research in toxicology 1992;5(4):470-8.
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1992: Raney K D; Coles B; Guengerich F P; Harris T M
The endo-8,9-epoxide of aflatoxin B1: a new metabolite.
Chemical research in toxicology 1992;5(3):333-5.
-
1992: Raney K D; Shimada T; Kim D H; Groopman J D; Harris T M; Guengerich F P
Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1.
Chemical research in toxicology 1992;5(2):202-10.
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1992: Guengerich F P; Raney K D; Kim D H; Shimada T; Meyer D J; Ketterer B; Harris T M
Oxidation and conjugation of aflatoxins by humans and experimental animals.
Progress in clinical and biological research 1992;374():157-65.
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1990: Gopalakrishnan S; Harris T M; Stone M P
Intercalation of aflatoxin B1 in two oligodeoxynucleotide adducts: comparative 1H NMR analysis of d(ATCAFBGAT).d(ATCGAT) and d(ATAFBGCAT)2.
Biochemistry 1990;29(46):10438-48.
-
1990: Wickwire B M; Harris C M; Harris T M; Broquist H P
Pipecolic acid biosynthesis in Rhizoctonia leguminicola. I. The lysine saccharopine, delta 1-piperideine-6-carboxylic acid pathway.
The Journal of biological chemistry 1990;265(25):14742-7.
-
1990: Raney K D; Gopalakrishnan S; Byrd S; Stone M P; Harris T M
Alteration of the aflatoxin cyclopentenone ring to a delta-lactone reduces intercalation with DNA and decreases formation of guanine N7 adducts by aflatoxin epoxides.
Chemical research in toxicology 1990;3(3):254-61.
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1990: Atsmon J; Sweetman B J; Baertschi S W; Harris T M; Roberts L J
Formation of thiol conjugates of 9-deoxy-delta 9,delta 12(E)-prostaglandin D2 and delta 12(E)-prostaglandin D2.
Biochemistry 1990;29(15):3760-5.
-
1990: Brash A R; Baertschi S W; Harris T M
Formation of prostaglandin A analogues via an allene oxide.
The Journal of biological chemistry 1990;265(12):6705-12.
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1990: Morrow J D; Harris T M; Roberts L J
Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids.
Analytical biochemistry 1990;184(1):1-10.
-
1990: Harris T M
NMR-studies of carcinogen reactions with DNA: ethylene dibromide and aflatoxin B1.
Journal of pharmaceutical and biomedical analysis 1990;8(2):195-204.
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1989: Baertschi S W; Raney K D; Shimada T; Harris T M; Guengerich F P
Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses.
Chemical research in toxicology 1989;2(2):114-2.
-
1989: Bondon A; Macdonald T L; Harris T M; Guengerich F P
Oxidation of cycloalkylamines by cytochrome P-450. Mechanism-based inactivation, adduct formation, ring expansion, and nitrone formation.
The Journal of biological chemistry 1989;264(4):1988-97.
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1989: Gopalakrishnan S; Byrd S; Stone M P; Harris T M
Carcinogen-nucleic acid interactions: equilibrium binding studies of aflatoxin B1 with the oligodeoxynucleotide d(ATGCAT)2 and with plasmid pBR322 support intercalative association with the B-DNA helix.
Biochemistry 1989;28(2):726-34.
-
1989: Brash A R; Baertschi S W; Ingram C D; Harris T M
Allene oxides as intermediates in biosynthesis of ketols and cyclopentenones.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():70-3.
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1988: Topping R J; Stone M P; Brush C K; Harris T M
Non-Watson-Crick structures in oligodeoxynucleotides: self-association of d(TpCpGpA) stabilized at acidic pH.
Biochemistry 1988;27(19):7216-22.
-
1988: Brash A R; Baertschi S W; Ingram C D; Harris T M
Isolation and characterization of natural allene oxides: unstable intermediates in the metabolism of lipid hydroperoxides.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(10):3382-6.
-
1988: Stone M P; Gopalakrishnan S; Harris T M; Graves D E
Carcinogen-nucleic acid interactions: equilibrium binding studies of aflatoxins B1 and B2 with DNA and the oligodeoxynucleotide d(ATGCAT)2.
Journal of biomolecular structure & dynamics 1988;5(5):1025-41.
-
1988: Harris T M; Stone M P; Harris C M
Applications of NMR spectroscopy to studies of reactive intermediates and their interactions with nucleic acids.
Chemical research in toxicology 1988;1(2):79-96.
-
1988: Hodge R P; Harris C M; Harris T M
Verrucofortine, a major metabolite of Penicillium verrucosum var. cyclopium, the fungus that produces the mycotoxin verrucosidin.
Journal of natural products 1988;51(1):66-73.
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1988: Baertschi S W; Ingram C D; Harris T M; Brash A R
Absolute configuration of cis-12-oxophytodienoic acid of flaxseed: implications for the mechanism of biosynthesis from the 13(S)-hydroperoxide of linolenic acid.
Biochemistry 1988;27(1):18-24.
-
1988: Brush C K; Stone M P; Harris T M
Selective reversible deuteriation of oligodeoxynucleotides: simplification of two-dimensional nuclear Overhauser effect NMR spectral assignment of a non-self-complementary dodecamer duplex.
Biochemistry 1988;27(1):115-22.
-
1987: Brash A R; Baertschi S W; Ingram C D; Harris T M
On non-cyclooxygenase prostaglandin synthesis in the sea whip coral, Plexaura homomalla: an 8(R)-lipoxygenase pathway leads to formation of an alpha-ketol and a Racemic prostanoid.
The Journal of biological chemistry 1987;262(33):15829-39.
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1987: Schaefer W H; Harris T M; Guengerich F P
Reaction of the model thiol 2-mercaptoethanol and glutathione with methylvinylmaleimide, a Michael acceptor with extended conjugation.
Archives of biochemistry and biophysics 1987;257(1):186-93.
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1987: Brash A R; Ingram C D; Harris T M
Analysis of a specific oxygenation reaction of soybean lipoxygenase-1 with fatty acids esterified in phospholipids.
Biochemistry 1987;26(17):5465-71.
-
1987: Tamura M; Harris T M; Higashimori K; Sweetman B J; Blair I A; Inagami T
Lysophosphatidylcholines containing polyunsaturated fatty acids were found as Na+, K+-ATPase inhibitors in acutely volume-expanded hog.
Biochemistry 1987;26(10):2797-806.
-
1986: Koga N; Inskeep P B; Harris T M; Guengerich F P
S-[2-(N7-guanyl)ethyl]glutathione, the major DNA adduct formed from 1,2-dibromoethane.
Biochemistry 1986;25(8):2192-8.
-
1986: Glasgow W C; Harris T M; Brash A R
A short-chain aldehyde is a major lipoxygenase product in arachidonic acid-stimulated porcine leukocytes.
The Journal of biological chemistry 1986;261(1):200-4.
-
1985: Schaefer W H; Harris T M; Guengerich F P
Characterization of the enzymatic and nonenzymatic peroxidative degradation of iron porphyrins and cytochrome P-450 heme.
Biochemistry 1985;24(13):3254-63.
-
1985: Harris C M; Kopecka H; Harris T M
The stabilization of vancomycin by peptidoglycan analogs.
The Journal of antibiotics 1985;38(1):51-7.
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1984: Broquist H P; Mason P S; Hagler W M; Harris T M
Identification of swainsonine as a probable contributory mycotoxin in moldy forage mycotoxicoses.
Applied and environmental microbiology 1984;48(2):386-8.
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1983: Murthy S V; Melly M A; Harris T M; Hellerqvist C G; Hash J H
The repeating sequence of the capsular polysaccharide of Staphylococcus aureus M.
Carbohydrate research 1983;117():113-23.
-
1982: Tulsiani D R; Harris T M; Touster O
Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II.
The Journal of biological chemistry 1982;257(14):7936-9.
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1981: Schraw W P; Regen D M; Harris T M
Inhibition of glucose transport by benzoquinone and the addition product of benzoquinone and dithiothreitol.
Biochimica et biophysica acta 1981;649(3):735-42.
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1980: Küpfer A; Brilis G M; Watson J T; Harris T M
A major pathway of mephenytoin metabolism in man. Aromatic hydroxylation to p-hydroxymephenytoin.
Drug metabolism and disposition: the biological fate of chemicals 1980;8(1):1-4.
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1979: Clevenstine E C; Walter P; Harris T M; Broquist H P
Biosynthesis of slaframine, (1S,6S,8aS)-1-acetoxy-6-aminooctahydroindolizine, a parasympathomimetic alkaloid of fungal origin. 4. Metabolic fate of ethyl pipecolylacetate, 1,3-dioxooctahydroindolizine, and 1-hydroxyoctahydroindolizine in Rhizoctonia leguminicola.
Biochemistry 1979;18(17):3663-7.
-
1979: Clevenstine E C; Broquist H P; Harris T M
Biosynthesis of slaframine, (1S,6S,8aS)-1-acetoxy-6-aminooctahydroindolizine, a parasympathomimetic alkaloid of fungal origin. 3. Origin of the pyrrolidine ring.
Biochemistry 1979;18(17):3658-63.
-
1979: Sztaricskai F; Harris C M; Harris T M
Structural investigation of the antibiotic ristomycin A. The amino acid constituents.
The Journal of antibiotics 1979;32(5):446-52.
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1977: Burka L T; Kuhnert L; Wilson B J; Harris T M
Biogenesis of lung-toxic furans produced during microbial infection of sweet potatoes (Ipomoea batatas).
Journal of the American Chemical Society 1977;99(7):2302-5.
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1976: Harris T M; Webb A D; Harris C M; Wittek P J; Murray T P
Letter: Biogenetic-type syntheses of emodin and chrysophanol.
Journal of the American Chemical Society 1976;98(19):6065-7.
-
1976: Harris C M; Roberson J S; Harris T M
Biosynthesis of griseofulvin.
Journal of the American Chemical Society 1976;98(17):5380-6.
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1974: Burka L T; Bowen R M; Wilson B J; Harris T M
7-hydroxymyoporone, a new toxic furanosesquiterpene from mold-damaged sweet potatoes.
The Journal of organic chemistry 1974;39(22):3241-4.
-
1974: Burka L T; Wilson B J; Harris T M
A synthesis of racemic ipomeamarone and epiipomeamarone.
The Journal of organic chemistry 1974;39(15):2212-4.
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1974: Boyd M R; Burka L T; Harris T M; Wilson B J
Lung-toxic furanoterpenoids produced by sweet potatoes (Ipomoea batatas) following microbial infection.
Biochimica et biophysica acta 1974;337(2):184-95.
-
1974: Harris T M; Harris C M; Hindley K B
Biogenetic-type syntheses of polyketide metabolites.
Fortschritte der Chemie organischer Naturstoffe. Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles 1974;31(0):217-82.
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1973: Wilson B J; Yang D T; Harris T M
Production, isolation, and preliminary toxicity studies of brevianamide A from cultures of Penicillium viridicatum.
Applied microbiology 1973;26(4):633-5.
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1972: Boyd M R; Wilson B J; Harris T M
Confirmation by chemical synthesis of the structure of 4-ipomeanol, a lung-toxic metabolite of the sweet potato, Ipomoea batatas.
Nature: New biology 1972;236(66):158-9.
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1971: Cohen H J; Harris T M; Geller A M; Byrne W L
Bovine hepatic fructose 1,6-diphosphatase: -glycerophosphate hydrolysis-evidence for a shared active site.
Archives of biochemistry and biophysics 1971;146(1):144-52.
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1971: Byrne W L; Rajagopalan G T; Griffn L D; Ellis E H; Harris T M; Hochachka P; Reid L; Geller A M
Bovine hepatic fructose 1,6-diphosphatase: purification and properties.
Archives of biochemistry and biophysics 1971;146(1):118-33.
-
1971: Wilson B J; Boyd M R; Harris T M; Yang D T
A lung oedema factor from mouldy sweet potatoes (Ipomoea batatas).
Nature 1971;231(5297):52-3.
-
1967: Wilson B J; Harris T M; Hayes A W
Mycotoxin from Penicillium puberulum.
Journal of bacteriology 1967;93(5):1737-8.
-
1967: Harris T M; Harris C M
Condensation of 2,6-diphenyl-4-pyrone with carbanions.
The Journal of organic chemistry 1967;32(4):970-5.
-
1966: Harris T M; Harris C M; Light R J
The isolation of triacetic acid lactone from cultures of Penicillium patulum.
Biochimica et biophysica acta 1966;121(2):420-3.
-
1965: Harris T M
Deuterium exchange reactions at the 2-position of imidazoles.
Chemistry & industry 1965;41():1728-9.
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