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Robert Lasley

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P Charukeshi Chandrasekera; Elizabeth T Gizewski; John A Auchampach; Tina C Wan; Robert D Lasley
Adenosine A1 receptors heterodimerize with β1- and β2-adrenergic receptors creating novel receptor complexes with altered G protein coupling and signaling.
Victoria J McIntosh; Robert D Lasley
Adenosine receptor-mediated cardioprotection: are all 4 subtypes required or redundant?
Enbo Zhan; Victoria J McIntosh; Robert D Lasley
Adenosine A₂A and A₂B receptors are both required for adenosine A₁ receptor-mediated cardioprotection.

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2013: P Charukeshi Chandrasekera; Elizabeth T Gizewski; John A Auchampach; Tina C Wan; Robert D Lasley
Adenosine A1 receptors heterodimerize with β1- and β2-adrenergic receptors creating novel receptor complexes with altered G protein coupling and signaling.
Cellular signalling 2013;25(4):736-42.
2012: Victoria J McIntosh; Robert D Lasley
Adenosine receptor-mediated cardioprotection: are all 4 subtypes required or redundant?
Journal of cardiovascular pharmacology and therapeutics 2012;17(1):21-33.
2011: Enbo Zhan; Victoria J McIntosh; Robert D Lasley
Adenosine A₂A and A₂B receptors are both required for adenosine A₁ receptor-mediated cardioprotection.
American journal of physiology. Heart and circulatory physiology 2011;301(3):H1183-9.
2011: Victoria J McIntosh; P Charukeshi Chandrasekera; Robert D Lasley
Sex differences and the effects of ovariectomy on the β-adrenergic contractile response.
American journal of physiology. Heart and circulatory physiology 2011;301(3):H1127-34.
2011: Robert D Lasley
Adenosine receptors and membrane microdomains.
Biochimica et biophysica acta 2011;1808(5):1284-9.
2010: P Charukeshi Chandrasekera; Victoria J McIntosh; Frank X Cao; Robert D Lasley
Differential effects of adenosine A2a and A2b receptors on cardiac contractility.
American journal of physiology. Heart and circulatory physiology 2010;299(6):H2082-9.
2010: Robert D Lasley
Invited commentary.
The Annals of thoracic surgery 2010;90(5):1535-6.
2009: John P Headrick; Robert D Lasley
Adenosine receptors and reperfusion injury of the heart.
Handbook of experimental pharmacology 2009;(193):189-214.
2008: Cherry Ballard-Croft; Adam C Locklar; Byron J Keith; Robert M Mentzer; Robert D Lasley
Oxidative stress and adenosine A1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs.
American journal of physiology. Heart and circulatory physiology 2008;294(1):H263-71.
2007: Karsten Schulze; Conrad Duschek; Robert D Lasley; Rolf Bünger
Adenosine enhances cytosolic phosphorylation potential and ventricular contractility in stunned guinea pig heart: receptor-mediated and metabolic protection.
Journal of applied physiology (Bethesda, Md. : 1985) 2007;102(3):1202-13.
2007: Robert D Lasley; Gentian Kristo; Byron J Keith; Robert M Mentzer
The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium.
American journal of physiology. Heart and circulatory physiology 2007;292(1):H426-31.
2006: Cherry Ballard-Croft; Adam C Locklar; Gentian Kristo; Robert D Lasley
Regional myocardial ischemia-induced activation of MAPKs is associated with subcellular redistribution of caveolin and cholesterol.
American journal of physiology. Heart and circulatory physiology 2006;291(2):H658-67.
2005: Gentian Kristo; Yukihiro Yoshimura; Byron J Keith; Robert M Mentzer; Robert D Lasley
Aged rat myocardium exhibits normal adenosine receptor-mediated bradycardia and coronary vasodilation but increased adenosine agonist-mediated cardioprotection.
The journals of gerontology. Series A, Biological sciences and medical sciences 2005;60(11):1399-404.
2005: Robert D Lasley; Byron J Keith; Gentian Kristo; Yukihiro Yoshimura; Robert M Mentzer
Delayed adenosine A1 receptor preconditioning in rat myocardium is MAPK dependent but iNOS independent.
American journal of physiology. Heart and circulatory physiology 2005;289(2):H785-91.
2005: Robert D Lasley
New insights into adenosine-mediated myocardial protection.
British journal of pharmacology 2005;145(6):701-2.
2005: Easton A Reid; Gentian Kristo; Yukihiro Yoshimura; Cherry Ballard-Croft; Byron J Keith; Robert M Mentzer; Robert D Lasley
In vivo adenosine receptor preconditioning reduces myocardial infarct size via subcellular ERK signaling.
American journal of physiology. Heart and circulatory physiology 2005;288(5):H2253-9.
2005: Cherry Ballard-Croft; Gentian Kristo; Yukihiro Yoshimura; Easton A Reid; Byron J Keith; Robert M Mentzer; Robert D Lasley
Acute adenosine preconditioning is mediated by p38 MAPK activation in discrete subcellular compartments.
American journal of physiology. Heart and circulatory physiology 2005;288(3):H1359-66.
2004: Gentian Kristo; Yukihiro Yoshimura; Byron J Keith; Randy M Stevens; Salik A Jahania; Robert M Mentzer; Robert D Lasley
Adenosine A1/A2a receptor agonist AMP-579 induces acute and delayed preconditioning against in vivo myocardial stunning.
American journal of physiology. Heart and circulatory physiology 2004;287(6):H2746-53.
2004: Yukihiro Yoshimura; Gentian Kristo; Byron J Keith; Salik A Jahania; Robert M Mentzer; Robert D Lasley
The p38 MAPK inhibitor SB203580 blocks adenosine A(1) receptor-induced attenuation of in vivo myocardial stunning.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2004;18(6):433-40.
2004: Gentian Kristo; Yukihiro Yoshimura; Suellen P Ferraris; Salik A Jahania; Robert M Mentzer; Robert D Lasley
The preischemic combination of the sodium-hydrogen exchanger inhibitor cariporide and the adenosine agonist AMP579 acts additively to reduce porcine myocardial infarct size.
Journal of the American College of Surgeons 2004;199(4):586-94.
2004: Randy M Stevens; M Salik Jahania; Robert M Mentzer; Robert D Lasley
Sodium-hydrogen exchange inhibition attenuates in vivo porcine myocardial stunning.
The Annals of thoracic surgery 2004;77(2):651-7.
2004: Gentian Kristo; Yukihiro Yoshimura; Jianli Niu; Byron J Keith; Robert M Mentzer; Rolf Bünger; Robert D Lasley
The intermediary metabolite pyruvate attenuates stunning and reduces infarct size in in vivo porcine myocardium.
American journal of physiology. Heart and circulatory physiology 2004;286(2):H517-24.
2003: Dan Chalothorn; Dan F McCune; Stephanie Edelmann; Kimimasa Tobita; Bradley B Keller; Robert D Lasley; Dianne M Perez; Akito Tanoue; Gozoh Tsujimoto; Ginell R Post; Michael T Piascik
Differential cardiovascular regulatory activities of the alpha 1B- and alpha 1D-adrenoceptor subtypes.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1045-53.
2003: Robert M Mentzer; Robert D Lasley; Andreas Jessel; Morris Karmazyn
Intracellular sodium hydrogen exchange inhibition and clinical myocardial protection.
The Annals of thoracic surgery 2003;75(2):S700-8.
2002: Randy M Stevens; Mohammed Salik Jahania; Jennifer E Stivers; Robert M Mentzer; Robert D Lasley
Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites.
The Annals of thoracic surgery 2002;73(4):1261-6.
2002: Eric L Kilpatrick; Prakash Narayan; Robert M Mentzer; Robert D Lasley
Cardiac myocyte adenosine A2a receptor activation fails to alter cAMP or contractility: role of receptor localization.
American journal of physiology. Heart and circulatory physiology 2002;282(3):H1035-40.
2001: Prakash Narayan; Robert M Mentzer; Robert D Lasley
Annexin V staining during reperfusion detects cardiomyocytes with unique properties.
American journal of physiology. Heart and circulatory physiology 2001;281(5):H1931-7.
2001: Robert D Lasley; Eric J Smart
Cardiac myocyte adenosine receptors and caveolae.
Trends in cardiovascular medicine 2001;11(7):259-63.
2001: E L Kilpatrick; Prakash Narayan; Robert M Mentzer; Robert D Lasley
Adenosine A3 agonist cardioprotection in isolated rat and rabbit hearts is blocked by the A1 antagonist DPCPX.
American journal of physiology. Heart and circulatory physiology 2001;281(2):H847-53.
2001: Zhenhai Gao; Zhihe Li; S P Baker; Robert D Lasley; Stephanie Meyer; Elfatih Elzein; Venkata Palle; Jeff Zablocki; Brent Blackburn; Luiz Belardinelli
Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2A agonists.
The Journal of pharmacology and experimental therapeutics 2001;298(1):209-18.
2001: Robert D Lasley; Mohammed Salik Jahania; Robert M Mentzer
Beneficial effects of adenosine A(2a) agonist CGS-21680 in infarcted and stunned porcine myocardium.
American journal of physiology. Heart and circulatory physiology 2001;280(4):H1660-6.
2001: Prakash Narayan; Robert M Mentzer; Robert D Lasley
Adenosine A1 receptor activation reduces reactive oxygen species and attenuates stunning in ventricular myocytes.
Journal of molecular and cellular cardiology 2001;33(1):121-9.
2000: Mohammed Salik Jahania; Timothy W Mullett; Juan Sanchez; Prakash Narayan; Robert D Lasley; Robert M Mentzer
Acute allograft failure in thoracic organ transplantation.
Journal of cardiac surgery 2000;15(2):122-8.
2000: Robert D Lasley; Prakash Narayan; Annette Uittenbogaard; Eric J Smart
Activated cardiac adenosine A(1) receptors translocate out of caveolae.
The Journal of biological chemistry 2000;275(6):4417-21.
2000: Prakash Narayan; Robert M Mentzer; Robert D Lasley
Phosphatase inhibitor cantharidin blocks adenosine A(1) receptor anti-adrenergic effect in rat cardiac myocytes.
American journal of physiology. Heart and circulatory physiology 2000;278(1):H1-7.
1999: Mohammed Salik Jahania; Juan Sanchez; Prakash Narayan; Robert D Lasley; Robert M Mentzer
Heart preservation for transplantation: principles and strategies.
The Annals of thoracic surgery 1999;68(5):1983-7.
1999: Robert D Lasley; Julia O Hegge; Mark A Noble; Robert M Mentzer
Evidence that cytosolic and ecto 5'-nucleotidases contribute equally to increased interstitial adenosine concentration during porcine myocardial ischemia.
Basic research in cardiology 1999;94(3):199-207.
1999: Robert D Lasley; Prakash Narayan; Mohammed Salik Jahania; E L Partin; K R Kraft; Robert M Mentzer
Species-dependent hemodynamic effects of adenosine A3-receptor agonists IB-MECA and Cl-IB-MECA.
The American journal of physiology 1999;276(6 Pt 2):H2076-84.
1999: Robert M Mentzer; V Birjiniuk; Shukri Khuri; J E Lowe; P S Rahko; R D Weisel; H A Wellons; M L Barker; Robert D Lasley
Adenosine myocardial protection: preliminary results of a phase II clinical trial.
Annals of surgery 1999;229(5):643-9; discussion 649-50.
1999: Robert D Lasley; M P Randhawa; Julia O Hegge; Robert M Mentzer
Effects of adenosine and acadesine on interstitial nucleosides and myocardial stunning in the pig.
Canadian journal of physiology and pharmacology 1999;77(4):259-67.
1999: Mohammed Salik Jahania; Robert D Lasley; Robert M Mentzer
Ischemic preconditioning does not acutely improve load-insensitive parameters of contractility in in vivo stunned porcine myocardium.
The Journal of thoracic and cardiovascular surgery 1999;117(4):810-7.
1998: Robert D Lasley; BJ Martin; Héctor H Valdivia; Robert M Mentzer; Rolf Bünger
Metabolic inotropy and calcium transients in isolated rat cardiomyocytes.
Annals of the New York Academy of Sciences 1998;853():308-10.
1998: Robert D Lasley; Zhengfeng Zhou; Julia O Hegge; Rolf Bünger; Robert M Mentzer
Adenosine attenuates in vivo myocardial stunning with minimal effects on cardiac energetics.
Basic research in cardiology 1998;93(4):303-12.
1998: Robert D Lasley; Robert M Mentzer
Dose-dependent effects of adenosine on interstitial fluid adenosine and postischemic function in the isolated rat heart.
The Journal of pharmacology and experimental therapeutics 1998;286(2):806-11.
1998: David A Mei; Kasem Nithipatikom; Robert D Lasley; Garrett J Gross
Myocardial preconditioning produced by ischemia, hypoxia, and a KATP channel opener: effects on interstitial adenosine in dogs.
Journal of molecular and cellular cardiology 1998;30(6):1225-36.
1998: Robert D Lasley; Julia O Hegge; Mark A Noble; Robert M Mentzer
Comparison of interstitial fluid and coronary venous adenosine levels in in vivo porcine myocardium.
Journal of molecular and cellular cardiology 1998;30(6):1137-47.
1998: Prakash Narayan; Héctor H Valdivia; Robert M Mentzer; Robert D Lasley
Adenosine A1 receptor stimulation antagonizes the negative inotropic effects of the PKC activator dioctanoylglycerol.
Journal of molecular and cellular cardiology 1998;30(5):913-21.
1998: Robert M Mentzer; Mohammed Salik Jahania; Robert D Lasley
Tacrolimus as a rescue immunosuppressant after heart and lung transplantation. The U.S. Multicenter FK506 Study Group.
Transplantation 1998;65(1):109-13.
1998: BJ Martin; Héctor H Valdivia; Rolf Bünger; Robert D Lasley; Robert M Mentzer
Pyruvate augments calcium transients and cell shortening in rat ventricular myocytes.
The American journal of physiology 1998;274(1 Pt 2):H8-17.
1997: Robert D Lasley; Mark A Noble; Robert M Mentzer
Effects of protein kinase C inhibitors in in situ and isolated ischemic rabbit myocardium.
Journal of molecular and cellular cardiology 1997;29(12):3345-56.
1997: C Valdivia; Julia O Hegge; Robert D Lasley; Héctor H Valdivia; Robert M Mentzer
Ryanodine receptor dysfunction in porcine stunned myocardium.
The American journal of physiology 1997;273(2 Pt 2):H796-804.
1997: Robert M Mentzer; P S Rahko; V Molina-Viamonte; Charles C Canver; P S Chopra; Robert B Love; T D Cook; Julia O Hegge; Robert D Lasley
Safety, tolerance, and efficacy of adenosine as an additive to blood cardioplegia in humans during coronary artery bypass surgery.
The American journal of cardiology 1997;79(12A):38-43.
1997: BJ Martin; Robert D Lasley; Robert M Mentzer
Infarct size reduction with the nucleoside transport inhibitor R-75231 in swine.
The American journal of physiology 1997;272(4 Pt 2):H1857-65.
1996: Robert M Mentzer; P S Rahko; Charles C Canver; P S Chopra; Robert B Love; T D Cook; M O Hegge; Robert D Lasley
Adenosine reduces postbypass transfusion requirements in humans after heart surgery.
Annals of surgery 1996;224(4):523-9; discussion 529-30.
1995: Robert D Lasley; Mark A Noble; P J Konyn; Robert M Mentzer
Different effects of an adenosine A1 analogue and ischemic preconditioning in isolated rabbit hearts.
The Annals of thoracic surgery 1995;60(6):1698-703.
1995: Zhengfeng Zhou; Robert D Lasley; Julia O Hegge; Rolf Bünger; Robert M Mentzer
Myocardial stunning: a therapeutic conundrum.
The Journal of thoracic and cardiovascular surgery 1995;110(5):1391-400; discussion 1400-1.
1995: Robert D Lasley; P J Konyn; Julia O Hegge; Robert M Mentzer
Effects of ischemic and adenosine preconditioning on interstitial fluid adenosine and myocardial infarct size.
The American journal of physiology 1995;269(4 Pt 2):H1460-6.
1995: Robert D Lasley; Robert M Mentzer
Protective effects of adenosine in the reversibly injured heart.
The Annals of thoracic surgery 1995;60(3):843-6.
1995: M P Randhawa; Robert D Lasley; Robert M Mentzer
Salutary effects of exogenous adenosine administration on in vivo myocardial stunning.
The Journal of thoracic and cardiovascular surgery 1995;110(1):63-74.
1995: Robert D Lasley; Robert M Mentzer
Preconditioning and its potential role in myocardial protection during cardiac surgery.
Journal of cardiac surgery 1995;10(4 Pt 1):349-53.
1994: Robert D Lasley; Mark A Noble; K L Paulsen; Robert M Mentzer
Adenosine attenuates phorbol ester-induced negative inotropic and vasoconstrictive effects in rat hearts.
The American journal of physiology 1994;266(6 Pt 2):H2159-66.
1994: Robert D Lasley; Robert M Mentzer
The role of adenosine in extended myocardial preservation with the University of Wisconsin solution.
The Journal of thoracic and cardiovascular surgery 1994;107(5):1356-63.
1994: Robert D Lasley; Rolf Bünger; Zhengfeng Zhou; Robert M Mentzer
Metabolically based treatment of stunned myocardium.
Journal of cardiac surgery 1994;9(3 Suppl):469-73.
1993: Robert D Lasley
Ischemic preconditioning and adenosine release.
Circulation 1993;88(3):1354; author reply 1359-60.
1993: Robert D Lasley; Robert M Mentzer
Pertussis toxin blocks adenosine A1 receptor mediated protection of the ischemic rat heart.
Journal of molecular and cellular cardiology 1993;25(7):815-21.
1993: Robert D Lasley; G M Anderson; Robert M Mentzer
Ischaemic and hypoxic preconditioning enhance postischaemic recovery of function in the rat heart.
Cardiovascular research 1993;27(4):565-70.
1993: M P Randhawa; Robert D Lasley; Robert M Mentzer
Adenosine and the stunned heart.
Journal of cardiac surgery 1993;8(2 Suppl):332-7.
1993: Robert D Lasley; Robert M Mentzer
Adenosine increases lactate release and delays onset of contracture during global low flow ischaemia.
Cardiovascular research 1993;27(1):96-101.
1993: Robert M Mentzer; Rolf Bünger; Robert D Lasley
Adenosine enhanced preservation of myocardial function and energetics. Possible involvement of the adenosine A1 receptor system.
Cardiovascular research 1993;27(1):28-35.
1992: Robert D Lasley; Robert M Mentzer
Adenosine improves recovery of postischemic myocardial function via an adenosine A1 receptor mechanism.
The American journal of physiology 1992;263(5 Pt 2):H1460-5.
1992: D G Van Wylen; T J Schmit; Robert D Lasley; R L Gingell; Robert M Mentzer
Cardiac microdialysis in isolated rat hearts: interstitial purine metabolites during ischemia.
The American journal of physiology 1992;262(6 Pt 2):H1934-8.
1990: D G Van Wylen; J Willis; J Sodhi; R J Weiss; Robert D Lasley; Robert M Mentzer
Cardiac microdialysis to estimate interstitial adenosine and coronary blood flow.
The American journal of physiology 1990;258(6 Pt 2):H1642-9.
1990: Robert D Lasley; J W Rhee; D G Van Wylen; Robert M Mentzer
Adenosine A1 receptor mediated protection of the globally ischemic isolated rat heart.
Journal of molecular and cellular cardiology 1990;22(1):39-47.
1989: D A Wyatt; M C Edmunds; Rafael G Rubio; R M Berne; Robert D Lasley; Robert M Mentzer
Adenosine stimulates glycolytic flux in isolated perfused rat hearts by A1-adenosine receptors.
The American journal of physiology 1989;257(6 Pt 2):H1952-7.
1989: Robert M Mentzer; D G Van Wylen; J Sodhi; R J Weiss; Robert D Lasley; J Willis; Rolf Bünger; L M Flint
Effect of pyruvate on regional ventricular function in normal and stunned myocardium.
Annals of surgery 1989;209(5):629-33; discussion 633-4.
1989: D A Wyatt; S W Ely; Robert D Lasley; R Walsh; R Mainwaring; R M Berne; Robert M Mentzer
Purine-enriched asanguineous cardioplegia retards adenosine triphosphate degradation during ischemia and improves postischemic ventricular function.
The Journal of thoracic and cardiovascular surgery 1989;97(5):771-8.
1988: R Mainwaring; Robert D Lasley; Rafael G Rubio; D A Wyatt; Robert M Mentzer
Adenosine stimulates glucose uptake in the isolated rat heart.
Surgery 1988;103(4):445-9.
1988: Robert M Mentzer; S W Ely; Robert D Lasley; R M Berne
The acute effects of AICAR on purine nucleotide metabolism and postischemic cardiac function.
The Journal of thoracic and cardiovascular surgery 1988;95(2):286-93.
1988: Robert D Lasley; S W Ely; R M Berne; Robert M Mentzer
Allopurinol enhanced adenine nucleotide repletion after myocardial ischemia in the isolated rat heart.
The Journal of clinical investigation 1988;81(1):16-20.
1985: S W Ely; Robert M Mentzer; Robert D Lasley; B K Lee; R M Berne
Functional and metabolic evidence of enhanced myocardial tolerance to ischemia and reperfusion with adenosine.
The Journal of thoracic and cardiovascular surgery 1985;90(4):549-56.
1985: Robert M Mentzer; S W Ely; Robert D Lasley; R D Mainwaring; E M Wright; R M Berne
Hormonal role of adenosine in maintaining patency of the ductus arteriosus in fetal lambs.
Annals of surgery 1985;202(2):223-30.
1985: L A Wolfe; R P Martin; D D Watson; Robert D Lasley; David Bruns
Chronic exercise and left ventricular structure and function in healthy human subjects.
Journal of applied physiology (Bethesda, Md. : 1985) 1985;58(2):409-15.