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Saroj Mathupala

Research Profile

Chemicals & Drugs

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Publications

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Chaim B Colen; Todd B Francis; matthew galloway; Farhad Ghoddoussi; Brandon J Koch; Michael D Monterey; Yimin Shen; Andrew E Sloan; Pingyang Yu; Saroj P Mathupala
Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study.
Saroj P Mathupala
Metabolic targeting of malignant tumors: small-molecule inhibitors of bioenergetic flux.
Saroj P Mathupala; Peter L Pedersen
Voltage dependent anion channel-1 (VDAC-1) as an anti-cancer target.

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All Publications

2011: Chaim B Colen; Todd B Francis; matthew galloway; Farhad Ghoddoussi; Brandon J Koch; Michael D Monterey; Yimin Shen; Andrew E Sloan; Pingyang Yu; Saroj P Mathupala
Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study.
Neoplasia (New York, N.Y.) 2011;13(7):620-32.
2011: Saroj P Mathupala
Metabolic targeting of malignant tumors: small-molecule inhibitors of bioenergetic flux.
Recent patents on anti-cancer drug discovery 2011;6(1):6-14.
2010: Saroj P Mathupala; Peter L Pedersen
Voltage dependent anion channel-1 (VDAC-1) as an anti-cancer target.
Cancer biology & therapy 2010;9(12):1053-6.
2010: Saroj P Mathupala; Young H Ko; Peter L Pedersen
The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies.
Biochimica et biophysica acta 2010;1797(6-7):1225-30.
2009: Saroj P Mathupala; Andrew A Sloan
An agarose-based cloning-ring anchoring method for isolation of viable cell clones.
BioTechniques 2009;46(4):305-7.
2009: Saroj P Mathupala
Delivery of small-interfering RNA (siRNA) to the brain.
Expert opinion on therapeutic patents 2009;19(2):137-40.
2009: Saroj P Mathupala; Young H Ko; Peter L Pedersen
Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy.
Seminars in cancer biology 2009;19(1):17-24.
2007: Saroj P Mathupala; Sandeep Mittal; Murali Guthikonda; Andrew E Sloan
MicroRNA and brain tumors: a cause and a cure?
DNA and cell biology 2007;26(5):301-10.
2007: Prahlad Parajuli; Saroj P Mathupala; Sandeep Mittal; Andrew E Sloan
Dendritic cell-based active specific immunotherapy for malignant glioma.
Expert opinion on biological therapy 2007;7(4):439-48.
2007: Saroj P Mathupala; Chaim B Colen; Prahlad Parajuli; Andrew E Sloan
Lactate and malignant tumors: a therapeutic target at the end stage of glycolysis.
Journal of bioenergetics and biomembranes 2007;39(1):73-7.
2006: Chaim B Colen; Navid Seraji-Bozorgzad; Brian Marples; matthew galloway; Andrew E Sloan; Saroj P Mathupala
Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study.
Neurosurgery 2006;59(6):1313-23; discussion 1323-4.
2006: Saroj P Mathupala; Young Hee Ko; Peter L Pedersen
Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria.
Oncogene 2006;25(34):4777-86.
2006: Saroj P Mathupala; Murali Guthikonda; Andrew E Sloan
RNAi based approaches to the treatment of malignant glioma.
Technology in cancer research & treatment 2006;5(3):261-9.
2004: Saroj P Mathupala; Prahlad Parajuli; Andrew E Sloan
Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study.
Neurosurgery 2004;55(6):1410-9; discussion 1419.
2004: Prahlad Parajuli; Saroj P Mathupala; Andrew E Sloan
Systematic comparison of dendritic cell-based immunotherapeutic strategies for malignant gliomas: in vitro induction of cytolytic and natural killer-like T cells.
Neurosurgery 2004;55(5):1194-204.
2003: Ashish Goel; Saroj P Mathupala; Peter L Pedersen
Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression.
The Journal of biological chemistry 2003;278(17):15333-40.
2002: Peter L Pedersen; Saroj P Mathupala; Annette Rempel; Jean-Francois H Geschwind; Young Hee Ko
Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention.
Biochimica et biophysica acta 2002;1555(1-3):14-20.
2002: Saroj P Mathupala; Andrew E Sloan
"In-gel" purified ditags direct synthesis of highly efficient SAGE Libraries.
BMC genomics 2002;3(1):20.
2001: Saroj P Mathupala; Annette Rempel; Peter L Pedersen
Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions.
The Journal of biological chemistry 2001;276(46):43407-12.
1997: Saroj P Mathupala; C Heese; Peter L Pedersen
Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53.
The Journal of biological chemistry 1997;272(36):22776-80.
1997: Saroj P Mathupala; Annette Rempel; Peter L Pedersen
Aberrant glycolytic metabolism of cancer cells: a remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for type II hexokinase.
Journal of bioenergetics and biomembranes 1997;29(4):339-43.
1996: A Rempel; Saroj P Mathupala; Constance A Griffin; Anita L Hawkins; Peter L Pedersen
Glucose catabolism in cancer cells: amplification of the gene encoding type II hexokinase.
Cancer research 1996;56(11):2468-71.
1996: A Rempel; Saroj P Mathupala; P L Perdersen
Glucose catabolism in cancer cells: regulation of the Type II hexokinase promoter by glucose and cyclic AMP.
FEBS letters 1996;385(3):233-7.
1995: Saroj P Mathupala; A Rempel; Peter L Pedersen
Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase.
The Journal of biological chemistry 1995;270(28):16918-25.
1993: Saroj P Mathupala; S E Lowe; S M Podkovyrov; J Gregory Zeikus
Sequencing of the amylopullulanase (apu) gene of Thermoanaerobacter ethanolicus 39E, and identification of the active site by site-directed mutagenesis.
The Journal of biological chemistry 1993;268(22):16332-44.
1990: B C Saha; R Lamed; C Y Lee; Saroj P Mathupala; J Gregory Zeikus
Characterization of an endo-Acting Amylopullulanase from Thermoanaerobacter Strain B6A.
Applied and environmental microbiology 1990;56(4):881-6.
1990: Saroj P Mathupala; B C Saha; J Gregory Zeikus
Substrate competition and specificity at the active site of amylopullulanase from Clostridium thermohydrosulfuricum.
Biochemical and biophysical research communications 1990;166(1):126-32.
1988: B C Saha; Saroj P Mathupala; J Gregory Zeikus
Purification and characterization of a highly thermostable novel pullulanase from Clostridium thermohydrosulfuricum.
The Biochemical journal 1988;252(2):343-8.