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Mark Paine

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Chemicals & Drugs

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Amino Acid Sequences

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Evangelia Morou; Andrew J Dowd; Shavanthi Rajatileka; Andrew Steven; Janet Hemingway; Hilary Ranson; Mark Paine; John Vontas
A simple colorimetric assay for specific detection of glutathione-S transferase activity associated with DDT resistance in mosquitoes.
T S Matambo; Mark Paine; Maureen Coetzee; Lizette L Koekemoer
Sequence characterization of cytochrome P450 CYP6P9 in pyrethroid resistant and susceptible Anopheles funestus (Diptera: Culicidae).
Iris Karunker; Evangelia Morou; Dimitra Nikou; Ralf Nauen; Rotem Sertchook; Bradley J Stevenson; Mark Paine; Shai Morin; John Vontas
Structural model and functional characterization of the Bemisia tabaci CYP6CM1vQ, a cytochrome P450 associated with high levels of imidacloprid resistance.

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All Publications

2010: Evangelia Morou; Andrew J Dowd; Shavanthi Rajatileka; Andrew Steven; Janet Hemingway; Hilary Ranson; Mark Paine; John Vontas
A simple colorimetric assay for specific detection of glutathione-S transferase activity associated with DDT resistance in mosquitoes.
PLoS neglected tropical diseases 2010;4(8):.
2010: T S Matambo; Mark Paine; Maureen Coetzee; Lizette L Koekemoer
Sequence characterization of cytochrome P450 CYP6P9 in pyrethroid resistant and susceptible Anopheles funestus (Diptera: Culicidae).
Genetics and molecular research : GMR 2010;9(1):554-64.
2009: Iris Karunker; Evangelia Morou; Dimitra Nikou; Ralf Nauen; Rotem Sertchook; Bradley J Stevenson; Mark Paine; Shai Morin; John Vontas
Structural model and functional characterization of the Bemisia tabaci CYP6CM1vQ, a cytochrome P450 associated with high levels of imidacloprid resistance.
Insect biochemistry and molecular biology 2009;39(10):697-706.
2008: Panagiota Kapoli; Irene A Axarli; Dimitris Platis; Maria Fragoulaki; Mark Paine; Janet Hemingway; John Vontas; Nikolaos E Labrou
Engineering sensitive glutathione transferase for the detection of xenobiotics.
Biosensors & bioelectronics 2008;24(3):498-503.
2008: Pie Müller; Emma Warr; Bradley J Stevenson; Patricia Pignatelli; John C Morgan; Andrew Steven; Alexander E Yawson; Sara N Mitchell; Hilary Ranson; Janet Hemingway; Mark Paine; Martin J Donnelly
Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids.
PLoS genetics 2008;4(11):e1000286.
2008: Yury Kapelyukh; Mark Paine; Jean-Didier Marechal; Michael J Sutcliffe; C Roland Wolf; Gordon Roberts
Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(10):2136-44.
2008: Evangelia Morou; Hanafy M Ismail; Andrew J Dowd; Janet Hemingway; Nikolaos Labrou; Mark Paine; John Vontas
A dehydrochlorinase-based pH change assay for determination of DDT in sprayed surfaces.
Analytical biochemistry 2008;378(1):60-4.
2008: Lesley A McLaughlin; U Niazi; J Bibby; J-P David; J Vontas; J Hemingway; H Ranson; M J Sutcliffe; Mark Paine
Characterization of inhibitors and substrates of Anopheles gambiae CYP6Z2.
Insect molecular biology 2008;17(2):125-35.
2008: Jean-Didier Marechal; C A Kemp; Gordon Roberts; Mark Paine; C Roland Wolf; Michael J Sutcliffe
Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.
British journal of pharmacology 2008;153 Suppl 1():S82-9.
2007: Dorota Kostrzewa-Nowak; Mark Paine; Anna Korytowska; Katarzyna Serwatka; Sylwia Piotrowska; C Roland Wolf; Jolanta Tarasiuk
Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase. Implications for increasing its ability to inhibit the growth of sensitive and multidrug resistant leukaemia HL60 cells.
Cancer letters 2007;245(1-2):252-62.
2006: Jinglei Yu; Mark Paine; Jean-Didier Marechal; Carol A Kemp; Clive J Ward; Simon Brown; Michael J Sutcliffe; Gordon Roberts; Elaine M Rankin; C Roland Wolf
In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(8):1386-92.
2006: Gareth J Lycett; Lesley A McLaughlin; H Ranson; J Hemingway; Fotis C Kafatos; Thanasis G Loukeris; Mark Paine
Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility.
Insect molecular biology 2006;15(3):321-7.
2006: Jean-Didier Marechal; Jinglei Yu; Simon Brown; Iouri Kapelioukh; Elaine M Rankin; C Roland Wolf; Gordon Roberts; Mark Paine; Michael J Sutcliffe
In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(4):534-8.
2006: Alex Grunau; Mark Paine; John E Ladbury; Aldo Gutierrez
Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.
Biochemistry 2006;45(5):1421-34.
2005: Lesley A McLaughlin; Mark Paine; Carol A Kemp; Jean-Didier Marechal; Jack U Flanagan; Clive J Ward; Michael J Sutcliffe; Gordon Roberts; C Roland Wolf
Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.
The Journal of biological chemistry 2005;280(46):38617-24.
2005: Dorota Kostrzewa-Nowak; Mark Paine; C Roland Wolf; Jolanta Tarasiuk
The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines.
British journal of cancer 2005;93(1):89-97.
2005: Robert D Finn; Murray Wilkie; Gillian Smith; Mark Paine
Identification of a functionally impaired allele of human novel oxidoreductase 1 (NDOR1), NDOR1*1.
Pharmacogenetics and genomics 2005;15(6):381-6.
2005: Robert D Finn; Iouri Kapelioukh; Mark Paine
Rainbow tags: a visual tag system for recombinant protein expression and purification.
BioTechniques 2005;38(3):387-8, 390-2.
2004: Carol A Kemp; Jack U Flanagan; Annamaria J van Eldik; Jean-Didier Marechal; C Roland Wolf; Gordon Roberts; Mark Paine; Michael J Sutcliffe
Validation of model of cytochrome P450 2D6: an in silico tool for predicting metabolism and inhibition.
Journal of medicinal chemistry 2004;47(22):5340-6.
2004: Jack U Flanagan; Jean-Didier Marechal; Richard Ward; Carol A Kemp; Lesley A McLaughlin; Michael J Sutcliffe; Gordon Roberts; Mark Paine; C Roland Wolf
Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
The Biochemical journal 2004;380(Pt 2):353-60.
2004: Jolanta Pawłowska; Waldemar Priebe; Mark Paine; C Roland Wolf; Edward Borowski; Jolanta Tarasiuk
The ability of new sugar-modified derivatives of antitumor anthracycline, daunorubicin, to stimulate NAD(P)H oxidation in different cellular oxidoreductase systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase.
Oncology research 2004;14(10):469-74.
2003: Aldo Gutierrez; Alex Grunau; Mark Paine; Andrew W Munro; C Roland Wolf; Gordon Roberts; Nigel S Scrutton
Electron transfer in human cytochrome P450 reductase.
Biochemical Society transactions 2003;31(Pt 3):497-501.
2003: Jack U Flanagan; Lesley A McLaughlin; Mark Paine; Michael J Sutcliffe; Gordon Roberts; C Roland Wolf
Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.
The Biochemical journal 2003;370(Pt 3):921-6.
2003: Robert D Finn; Jaswir Basran; Olivier Roitel; C Roland Wolf; Andrew W Munro; Mark Paine; Nigel S Scrutton
Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1.
European journal of biochemistry / FEBS 2003;270(6):1164-75.
2003: Mark Paine; Lesley A McLaughlin; Jack U Flanagan; Carol A Kemp; Michael J Sutcliffe; Gordon Roberts; C Roland Wolf
Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.
The Journal of biological chemistry 2003;278(6):4021-7.
2003: Jolanta Pawłowska; Jolanta Tarasiuk; C Roland Wolf; Mark Paine; Edward Borowski
Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase.
Oncology research 2003;13(5):245-52.
2002: Aldo Gutierrez; Mark Paine; C Roland Wolf; Nigel S Scrutton; Gordon Roberts
Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding.
Biochemistry 2002;41(14):4626-37.
2001: Y Y Deeni; Mark Paine; Andrew Ayrton; S E Clarke; RJ Chenery; C Roland Wolf
Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein.
Archives of biochemistry and biophysics 2001;396(1):16-24.
2001: Mark Paine; S Ayivor; Alastair Munro; P Tsan; Lu-Yun Lian; Gordon Roberts; C Roland Wolf
Role of the conserved phenylalanine 181 of NADPH-cytochrome P450 oxidoreductase in FMN binding and catalytic activity.
Biochemistry 2001;40(45):13439-47.
2001: O Döhr; Mark Paine; Thomas Friedberg; Gordon Roberts; C Roland Wolf
Engineering of a functional human NADH-dependent cytochrome P450 system.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):81-6.
2000: Aldo Gutierrez; O Doehr; Mark Paine; C Roland Wolf; Nigel S Scrutton; Gordon Roberts
Trp-676 facilitates nicotinamide coenzyme exchange in the reductive half-reaction of human cytochrome P450 reductase: properties of the soluble W676H and W676A mutant reductases.
Biochemistry 2000;39(51):15990-9.
2000: Mark Paine; A P Garner; D Powell; J Sibbald; Mark Sales; Norman Pratt; T Smith; D G Tew; C Roland Wolf
Cloning and characterization of a novel human dual flavin reductase.
The Journal of biological chemistry 2000;275(2):1471-8.
1999: A P Garner; Mark Paine; I Rodriguez-Crespo; Edwin C Chinje; Paul R. Ortiz de Montellano; Ian J Stratford; D G Tew; C Roland Wolf
Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents.
Cancer research 1999;59(8):1929-34.
1999: Q Zhao; S Modi; Gilliam Smith; Mark Paine; PD McDonagh; C Roland Wolf; D Tew; Lu-Yun Lian; Gordon Roberts; H P Driessen
Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution.
Protein science : a publication of the Protein Society 1999;8(2):298-306.
1997: Igor Barsukov; S Modi; Lu-Yun Lian; Kong Hung SZE; Mark Paine; C Roland Wolf; Gordon Roberts
1H, 15N and 13C NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450 reductase.
Journal of biomolecular NMR 1997;10(1):63-75.
1997: David Gilham; W Cairns; Mark Paine; S Modi; R Poulsom; Gordon Roberts; C Roland Wolf
Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(1):111-25.
1996: Ana Maria Moura da Silva; Gavin D Laing; Mark Paine; J M Dennison; V Politi; J M Crampton; R David G Theakston
Processing of pro-tumor necrosis factor-alpha by venom metalloproteinases: a hypothesis explaining local tissue damage following snake bite.
European journal of immunology 1996;26(9):2000-5.
1996: S Modi; Mark Paine; Michael J Sutcliffe; Lu-Yun Lian; WU Primrose; C Roland Wolf; Gordon Roberts
A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding.
Biochemistry 1996;35(14):4540-50.
1996: Mark Paine; D Gilham; Gordon Roberts; C Roland Wolf
Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.
Archives of biochemistry and biophysics 1996;328(1):143-50.
1996: Q Zhao; G Smith; S Modi; Mark Paine; R C Wolf; D Tew; Lu-Yun Lian; WU Primrose; Gordon Roberts; H P Driessen
Crystallization and preliminary X-ray diffraction studies of human cytochrome P450 reductase.
Journal of structural biology 1996;116(2):320-5.
1995: S Modi; Lu-Yun Lian; Gordon Roberts; G C Smith; Mark Paine; C Roland Wolf
Structural studies on FMN domain of cytochrome P450 reductase.
Biochemical Society transactions 1995;23(3):476S.
1995: Ana Maria Moura da Silva; Mark Paine; M R Diniz; R David G Theakston; J M Crampton
The molecular cloning of a phospholipase A2 from Bothrops jararacussu snake venom: evolution of venom group II phospholipase A2's may imply gene duplications.
Journal of molecular evolution 1995;41(2):174-9.
1995: S Nishida; T Fujita; N Kohno; H Atoda; T Morita; H Takeya; I Kido; Mark Paine; Shun-ichiro Kawabata; Sadaaki Iwanaga
cDNA cloning and deduced amino acid sequence of prothrombin activator (ecarin) from Kenyan Echis carinatus venom.
Biochemistry 1995;34(5):1771-8.
1994: J Cox-Singh; Mark Paine; S A Martin; E Devaney
Stage specific differences in steady state levels of mRNA encoding the major surface glycoprotein of Brugia pahangi.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ) 1994;45(4):352-4.
1994: Mark Paine; Ana Maria Moura da Silva; R David G Theakston; J M Crampton
Cloning of metalloprotease genes in the carpet viper (Echis pyramidum leakeyi). Further members of the metalloprotease/disintegrin gene family.
European journal of biochemistry / FEBS 1994;224(2):483-8.
1993: M R Diniz; Mark Paine; Carlos R Diniz; R David G Theakston; J M Crampton
Sequence of the cDNA coding for the lethal neurotoxin Tx1 from the Brazilian "armed" spider Phoneutria nigriventer predicts the synthesis and processing of a preprotoxin.
The Journal of biological chemistry 1993;268(21):15340-2.
1992: Mark Paine; H P Desmond; R David G Theakston; J M Crampton
Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family.
The Journal of biological chemistry 1992;267(32):22869-76.
1992: Mark Paine; H P Desmond; R David G Theakston; J M Crampton
Gene expression in Echis carinatus (carpet viper) venom glands following milking.
Toxicon : official journal of the International Society on Toxinology 1992;30(4):379-86.