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Guojun Wu

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Anatomy

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Genes, Tumor Suppressor

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TOP 3
Fanyan Meng; Guojun Wu
The rejuvenated scenario of epithelial-mesenchymal transition (EMT) and cancer metastasis.
Haijun Zhang; Sherwin Wu; Wei Chen; Bas Kreike; Fanyan Meng; Fred R Miller; Seema Sethi; Guojun Wu
Engagement of I-branching {beta}-1, 6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and TGF-{beta} signaling.
Fanyan Meng; Haijun Zhang; Gang Liu; Bas Kreike; Wei Chen; Seema Sethi; Fred R Miller; Guojun Wu
p38γ mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer.

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All Publications

2012: Fanyan Meng; Guojun Wu
The rejuvenated scenario of epithelial-mesenchymal transition (EMT) and cancer metastasis.
Cancer metastasis reviews 2012;31(3-4):455-67.
2011: Haijun Zhang; Sherwin Wu; Wei Chen; Bas Kreike; Fanyan Meng; Fred R Miller; Seema Sethi; Guojun Wu
Engagement of I-branching {beta}-1, 6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and TGF-{beta} signaling.
Cancer research 2011;71(14):4846-56.
2011: Fanyan Meng; Haijun Zhang; Gang Liu; Bas Kreike; Wei Chen; Seema Sethi; Fred R Miller; Guojun Wu
p38γ mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer.
Neoplasia (New York, N.Y.) 2011;13(5):472-82.
2010: Guojun Wu
Recent progess in phosphoinositide 3-kinases: oncogenic properties and prognostic and therapeutic implications.
Current protein & peptide science 2010;11(6):425-35.
2010: Haijun Zhang; Di Chen; Jonathan Ringler; Wei Chen; Qiuzhi Cindy Cui; Stephen Ethier; Qingping Dou; Guojun Wu
Disulfiram treatment facilitates phosphoinositide 3-kinase inhibition in human breast cancer cells in vitro and in vivo.
Cancer research 2010;70(10):3996-4004.
2009: Dingxie Liu; Peng Hou; Zhi Liu; Guojun Wu ; Michael M. Xing
Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin.
Cancer research 2009;69(18):7311-9.
2008: Haijun Zhang; Gang Liu; Michele Dziubinski; Zeng-Quan Yang; Stephen Ethier; Guojun Wu
Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells.
Breast cancer research and treatment 2008;112(2):217-27.
2008: Myoung Sook Kim; Xiaofei Chang; Keishi Yamashita; JATIN NAGPAL; Jin Hyen Baek; Guojun Wu ; Barry Trink; Edward Ratovitski; M Mori; David Sidransky
Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma.
Oncogene 2008;27(25):3624-34.
2008: Myoung Sook Kim; Xiaofei Chang; JATIN NAGPAL; Keishi Yamashita; Jin Hyen Baek; S Dasgupta; Guojun Wu ; Motonobu Osada; J-H Woo; William H Westra; Barry Trink; Edward Ratovitski; Chulso Moon; David Sidransky
The N-methyl-D-aspartate receptor type 2A is frequently methylated in human colorectal carcinoma and suppresses cell growth.
Oncogene 2008;27(14):2045-54.
2008: Jun-Wei Liu; JATIN NAGPAL; Carmen Jeronimo; Ji Eun Lee; Rui Henrique; Myoung Sook Kim; Kimberly Laskie Ostrow; Keishi Yamashita; Vim van Criekinge; Guojun Wu ; Chulso Moon; Barry Trink; David Sidransky
Hypermethylation of MCAM gene is associated with advanced tumor stage in prostate cancer.
The Prostate 2008;68(4):418-26.
2008: Xing-Song Tian; Wen-Hong Zhou; Guojun Wu ; Jing-Zhong Sun; Ming-Hua Cong
[Inhibitive effects of mifepristone on growth of breast cancer: experiment with animal model].
Zhonghua yi xue za zhi 2008;88(8):559-63.
2008: Yi Jun Shen; Ding Wei Ye; Xu Dong Yao; Barry Trink; Xiao-yan Zhou; Shi-Lin Zhang; Bo Dai; Hai-Liang Zhang; Yao Zhu; Zhongmin Guo; Guojun Wu ; JATIN NAGPAL
Overexpression of CDC91L1 (PIG-U) in bladder urothelial cell carcinoma: correlation with clinical variables and prognostic significance.
BJU international 2008;101(1):113-9.
2007: Shaoyu Zhou; Sushant Kachhap; Wenyue Sun; Guojun Wu ; Alice Chuang; Luana Poeta; Lawson Grumbine; Suhail K Mithani; Aditi Chatterjee; Wayne M Koch; William H Westra; Anirban Maitra; Chad Glazer; Michael A Carducci; David Sidransky; Thomas McFate; Ajay Verma; Joseph A Califano
Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7540-5.
2007: Guojun Wu ; Zhongmin Guo; Xiaofei Chang; Myoung Sook Kim; JATIN NAGPAL; Junwei Liu; Joni Mäki; Kari I Kivirikko; Stephen Ethier; Barry Trink; David Sidransky
LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer.
Cancer research 2007;67(9):4123-9.
2007: Motonobu Osada; Hannah Lui Park; Min Joo Park; Jun-Wei Liu; Guojun Wu ; Barry Trink; David Sidransky
A p53-type response element in the GDF15 promoter confers high specificity for p53 activation.
Biochemical and biophysical research communications 2007;354(4):913-8.
2007: Wei-Wen Jiang; Marianna Zahurak; Zeng-tong Zhou; Hannah Lui Park; Zhong-Min Guo; Guojun Wu ; David Sidransky; Barry Trink; Joseph A Califano
Alterations of GPI transamidase subunits in head and neck squamous carcinoma.
Molecular cancer 2007;6():74.
2006: Guojun Wu ; Zhongmin Guo; Aditi Chatterjee; Xin Huang; Ethel Rubin; Feng Wu; Elizabeth Mambo; Xiaofei Chang; Motonobu Osada; Myoung Sook Kim; Chulso Moon; Joseph A Califano; Edward Ratovitski; Susanne M Gollin; Saraswati Sukumar; David Sidransky; Barry Trink
Overexpression of glycosylphosphatidylinositol (GPI) transamidase subunits phosphatidylinositol glycan class T and/or GPI anchor attachment 1 induces tumorigenesis and contributes to invasion in human breast cancer.
Cancer research 2006;66(20):9829-36.
2006: Motonobu Osada; Hannah Lui Park; Yuichi Nagakawa; Shahnaz Begum; Keishi Yamashita; Guojun Wu ; Myoung Sook Kim; Barry Trink; David Sidransky
A novel response element confers p63- and p73-specific activation of the WNT4 promoter.
Biochemical and biophysical research communications 2006;339(4):1120-8.
2005: Vasily Vasko; Shuiying Hu; Guojun Wu ; Jeffrey C Xing; Alexandr Larin; Victoria Savchenko; Barry Trink; Michael M. Xing
High prevalence and possible de novo formation of BRAF mutation in metastasized papillary thyroid cancer in lymph nodes.
The Journal of clinical endocrinology and metabolism 2005;90(9):5265-9.
2005: Guojun Wu ; Elizabeth Mambo; Zhongmin Guo; Shuiying Hu; Xin Huang; Susanne M Gollin; Barry Trink; Paul W Ladenson; David Sidransky; Michael M. Xing
Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors.
The Journal of clinical endocrinology and metabolism 2005;90(8):4688-93.
2005: Motonobu Osada; Hannah Lui Park; Yuichi Nagakawa; Keishi Yamashita; Alexey Fomenkov; Myoung Sook Kim; Guojun Wu ; Shuji Nomoto; Barry Trink; David Sidransky
Differential recognition of response elements determines target gene specificity for p53 and p63.
Molecular and cellular biology 2005;25(14):6077-89.
2005: Motonobu Osada; Yuichi Nagakawa; Hannah Lui Park; Keishi Yamashita; Guojun Wu ; Myoung Sook Kim; Alexey Fomenkov; Barry Trink; David Sidransky
p63-specific activation of the BPAG-1e promoter.
The Journal of investigative dermatology 2005;125(1):52-60.
2005: Guojun Wu ; Motonobu Osada; Zhongmin Guo; Alexey Fomenkov; Shahnaz Begum; Ming Zhao; Sunil Upadhyay; Michael M. Xing; Feng Wu; Chulso Moon; William H Westra; Wayne M Koch; Roberto Mantovani; Joseph A Califano; Edward Ratovitski; David Sidransky; Barry Trink
DeltaNp63alpha up-regulates the Hsp70 gene in human cancer.
Cancer research 2005;65(3):758-66.
2005: Guojun Wu ; Michael M. Xing; Elizabeth Mambo; Xin Huang; Junwei Liu; Zhongmin Guo; Aditi Chatterjee; David Goldenberg; Susanne M Gollin; Saraswati Sukumar; Barry Trink; David Sidransky
Somatic mutation and gain of copy number of PIK3CA in human breast cancer.
Breast cancer research : BCR 2005;7(5):R609-16.
2004: Yiping Huang; Guojun Wu ; Zhongmin Guo; Motonobu Osada; Tanya Fomenkov; Hannah Lui Park; Barry Trink; David Sidransky; Alexey Fomenkov; Edward Ratovitski
Altered sumoylation of p63alpha contributes to the split-hand/foot malformation phenotype.
Cell cycle (Georgetown, Tex.) 2004;3(12):1587-96.
2004: Zhongmin Guo; Jürgen F Linn; Guojun Wu ; Sarah L Anzick; Claus F Eisenberger; Sarel Halachmi; Yoram Cohen; Alexey Fomenkov; Mohammad Hoque; Kenji Okami; Gabriel Steiner; James M Engles; Motonobu Osada; Chulso Moon; Edward Ratovitski; Jeffrey M. Trent; Paul S Meltzer; William H Westra; Lambertus A L M Kiemeney; Mark P Schoenberg; David Sidransky; Barry Trink
CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer.
Nature medicine 2004;10(4):374-81.
2004: Michael M. Xing; Vasily Vasko; Giovanni Tallini; Alexandr Larin; Guojun Wu ; Robert Udelsman; Matthew D Ringel; Paul W Ladenson; David Sidransky
BRAF T1796A transversion mutation in various thyroid neoplasms.
The Journal of clinical endocrinology and metabolism 2004;89(3):1365-8.
2003: Guojun Wu ; Shuji Nomoto; Mohammad Hoque; Tatiana Dracheva; Motonobu Osada; Chyi-Chia Richard Lee; Seung Myung Dong; Zhongmin Guo; Nicole Benoit; Yoram Cohen; Peggy Rechthand; Joseph A Califano; Chulso Moon; Edward Ratovitski; Jin Jen; David Sidransky; Barry Trink
DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development.
Cancer research 2003;63(10):2351-7.
2003: Michael M. Xing; Yutaka Tokumaru; Guojun Wu ; William H Westra; Paul W Ladenson; David Sidransky
Hypermethylation of the Pendred syndrome gene SLC26A4 is an early event in thyroid tumorigenesis.
Cancer research 2003;63(9):2312-5.
2003: Yoram Cohen; Michael M. Xing; Elizabeth Mambo; Zhongmin Guo; Guojun Wu ; Barry Trink; Uziel Beller; William H Westra; Paul W Ladenson; David Sidransky
BRAF mutation in papillary thyroid carcinoma.
Journal of the National Cancer Institute 2003;95(8):625-7.
2001: Guojun Wu ; Colleen S Sinclair; Shannon R Hinson; James N Ingle; Patrick C Roche; Fergus J. Couch
Structural analysis of the 17q22-23 amplicon identifies several independent targets of amplification in breast cancer cell lines and tumors.
Cancer research 2001;61(13):4951-5.
2000: Kaili Wu; Shi-Wen (Albert) Jiang; Muthusamy Thangaraju; Guojun Wu ; Fergus J. Couch
Induction of the BRCA2 promoter by nuclear factor-kappa B.
The Journal of biological chemistry 2000;275(45):35548-56.
2000: Guojun Wu ; Colleen S Sinclair; J Paape; James N Ingle; Patrick C Roche; C David James; Fergus J. Couch
17q23 amplifications in breast cancer involve the PAT1, RAD51C, PS6K, and SIGma1B genes.
Cancer research 2000;60(19):5371-5.
1999: Fergus J. Couch; XY Wang; Guojun Wu ; Junqi Qian; Robert B Jenkins; C David James
Localization of PS6K to chromosomal region 17q23 and determination of its amplification in breast cancer.
Cancer research 1999;59(7):1408-11.