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Robin Humphreys

Research Profile

Chemicals & Drugs

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Troy A Luster; Thi-Sau Migone; Ipsita Mukherjee; Luke Oh; Stephen Ullrich; Christopher Ward; Jeffrey Carrell; Yun Hee Cho; Andy Garcia; Jeffrey Gill; Lizbeth Kelly; Robin Humphreys
Fusion toxin BLyS-gelonin inhibits growth of malignant human B cell lines in vitro and in vivo.
Maximilian Niyazi; Patrizia Marini; Peter T Daniel; Robin Humphreys; Verena Jendrossek; Claus Belka
Efficacy of triple therapies including ionising radiation, agonistic TRAIL antibodies and cisplatin.
Troy A Luster; Jeffrey A Carrell; Kathy McCormick; David Sun; Robin Humphreys
Mapatumumab and lexatumumab induce apoptosis in TRAIL-R1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib.

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All Publications

2012: Troy A Luster; Thi-Sau Migone; Ipsita Mukherjee; Luke Oh; Stephen Ullrich; Christopher Ward; Jeffrey Carrell; Yun Hee Cho; Andy Garcia; Jeffrey Gill; Lizbeth Kelly; Robin Humphreys
Fusion toxin BLyS-gelonin inhibits growth of malignant human B cell lines in vitro and in vivo.
PloS one 2012;7(10):e47361.
2009: Maximilian Niyazi; Patrizia Marini; Peter T Daniel; Robin Humphreys; Verena Jendrossek; Claus Belka
Efficacy of triple therapies including ionising radiation, agonistic TRAIL antibodies and cisplatin.
Oncology reports 2009;21(6):1455-60.
2009: Troy A Luster; Jeffrey A Carrell; Kathy McCormick; David Sun; Robin Humphreys
Mapatumumab and lexatumumab induce apoptosis in TRAIL-R1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib.
Molecular cancer therapeutics 2009;8(2):292-302.
2008: Robin Humphreys; Wendy Halpern
Trail receptors: targets for cancer therapy.
Advances in experimental medicine and biology 2008;615():127-58.
2007: Lianghua Bin; Jacqueline Thorburn; Lance R Thomas; Peter E Clark; Robin Humphreys; Andrew Thorburn
Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding.
The Journal of biological chemistry 2007;282(38):28189-94.
2007: Steffan Nawrocki; Jennifer Carew; Leslie Douglas; John L Cleveland; Robin Humphreys; Janet A Houghton
Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels.
Cancer research 2007;67(14):6987-94.
2007: Eleonora Petrucci; Luca Pasquini; Alessia Petronelli; ernestina saulle; Gualtiero Mariani; Roberta Riccioni; Mauro Biffoni; Gianluigi Ferretti; Pierluigi Benedetti Panici; Francesco Cognetti; Giovanni Scambia; Robin Humphreys; Cesare Peschle; Ugo Testa
A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells.
Gynecologic oncology 2007;105(2):481-92.
2007: ernestina saulle; Alessia Petronelli; Luca Pasquini; Eleonora Petrucci; Gualtiero Mariani; Mauro Biffoni; Gianluigi Ferretti; Giovanni Scambia; Pierluigi Benedetti Panici; Francesco Cognetti; Robin Humphreys; Cesare Peschle; Ugo Testa
Proteasome inhibitors sensitize ovarian cancer cells to TRAIL induced apoptosis.
Apoptosis : an international journal on programmed cell death 2007;12(4):635-55.
2006: Jing Gong; David Yang; Sahar Kohanim; Robin Humphreys; Lyle D Broemeling; Razelle Kurzrock
Novel in vivo imaging shows up-regulation of death receptors by paclitaxel and correlates with enhanced antitumor effects of receptor agonist antibodies.
Molecular cancer therapeutics 2006;5(12):2991-3000.
2006: Patrizia Marini; S Denzinger; D Schiller; S Kauder; Stefan Welz; Robin Humphreys; Peter Daniel; Verena Jendrossek; Wilfried Budach; Claus Belka
Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo.
Oncogene 2006;25(37):5145-54.
2006: Yu Zeng; Xiu-Xian Wu; Michele Fiscella; Osamu Shimada; Robin Humphreys; Vivian Albert; Yoshiyuki Kakehi
Monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) induces apoptosis in primary renal cell carcinoma cells in vitro and inhibits tumor growth in vivo.
International journal of oncology 2006;28(2):421-30.
2005: Georgios V Georgakis; Yang Li; Robin Humphreys; Michael Andreeff; Susan O'Brien; Mamoun Younes; Antonino Carbone; Vivian Albert; Anas Younes
Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death.
British journal of haematology 2005;130(4):501-10.
2005: Laurie Pukac; Palanisamy Kanakaraj; Robin Humphreys; Ralph Alderson; M Bloom; Cynthia Sung; Todd A Riccobene; R Johnson; Michele Fiscella; Angela Mahoney; Jeffrey Carrell; Ernest Boyd; Xiao-Tao Yao; Linyi Zhang; L Zhong; A von Kerczek; L Shepard; T Vaughan; B Edwards; Claire L. Dobson; TW Salcedo; Vivian Albert
HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo.
British journal of cancer 2005;92(8):1430-41.
2005: Kazuhiro Motoki; Eiji Mori; Atsushi Matsumoto; Mayumi Thomas; Takafumi Tomura; Robin Humphreys; Vivian Albert; Mari Muto; Hitoshi Yoshida; Masami Aoki; Taro Tamada; Ryota Kuroki; Hideaki Yoshida; Isao Ishida; Carl F Ware; Shiro Kataoka
Enhanced apoptosis and tumor regression induced by a direct agonist antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(8):3126-35.
2002: Robin Humphreys; Brian Bierie; Ling Zhao; Regina Raz; David Levy; Lothar Hennighausen
Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli.
Endocrinology 2002;143(9):3641-50.
2000: Robin Humphreys; Lothar Hennighausen
Transforming growth factor alpha and mouse models of human breast cancer.
Oncogene 2000;19(8):1085-91.
1999: Robin Humphreys; Lothar Hennighausen
Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(10):685-94.
1999: Robin Humphreys
Programmed cell death in the terminal endbud.
Journal of mammary gland biology and neoplasia 1999;4(2):213-20.
1997: Robin Humphreys; John P Lydon; Bert W O'Malley; J M Rosen
Use of PRKO mice to study the role of progesterone in mammary gland development.
Journal of mammary gland biology and neoplasia 1997;2(4):343-54.
1997: Robin Humphreys; Jeffrey M Rosen
Stably transfected HC11 cells provide an in vitro and in vivo model system for studying Wnt gene function.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(8):839-49.
1997: Robin Humphreys; John P Lydon; Bert W O'Malley; Jeffrey M Rosen
Mammary gland development is mediated by both stromal and epithelial progesterone receptors.
Molecular endocrinology (Baltimore, Md.) 1997;11(6):801-11.
1996: Robin Humphreys; M Krajewska; S Krnacik; R Jaeger; H Weiher; S Krajewski; J C Reed; richard jäger
Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis.
Development (Cambridge, England) 1996;122(12):4013-22.
1994: Jeffrey M Rosen; Robin Humphreys; S Krnacik; P Juo; Brian Raught
The regulation of mammary gland development by hormones, growth factors, and oncogenes.
Progress in clinical and biological research 1994;387():95-111.
1993: T A Bühler; T C Dale; C Kieback; Robin Humphreys; Jeffrey M Rosen
Localization and quantification of Wnt-2 gene expression in mouse mammary development.
Developmental biology 1993;155(1):87-96.
1989: N B Egen; W A Cuevas; P J McNamara; D W Sammons; Robin Humphreys; J Glenn Songer
Purification of the phospholipase D of Corynebacterium pseudotuberculosis by recycling isoelectric focusing.
American journal of veterinary research 1989;50(8):1319-22.
1988: V G Dwyer; B Benson; K H Kwan; Robin Humphreys; W J Ko; N H Lin; D W Sammons
A computer-enhanced comparative study of brain region polypeptides and proteins by two-dimensional gel electrophoresis.
Journal of pharmaceutical and biomedical analysis 1988;6(6-8):793-9.
1987: N B Egen; F E Russell; D W Sammons; Robin Humphreys; A L Guan; Francis S Markland
Isolation by preparative isoelectric focusing of a direct acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix (southern copperhead).
Toxicon : official journal of the International Society on Toxinology 1987;25(11):1189-98.