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Lluis Montoliu

Research Profile

Living Beings

Chemicals & Drugs

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Genes & Molecular Sequences

Transgenes

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Albinism

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Oculocutaneous Albinism

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Publications

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Alejandro López-Jiménez; Kari J Buck; Kora-Mareen Bühler; Victor Echeverry-Alzate; Stéphanie Giezendanner; E Giné; Lluis Montoliu; Rosario Moratalla; Pedro Olmos; Nicole A R Walter; Angel Santos; José Antonio López-Moreno
A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption.
Mónica Mártinez-García; Lluis Montoliu
Albinism in europe.
Lluis Montoliu
Mendel: a simple excel workbook to compare the observed and expected distributions of genotypes/phenotypes in transgenic and knockout mouse crosses involving up to three unlinked loci by means of a χ2 test.

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2013: Alejandro López-Jiménez; Kari J Buck; Kora-Mareen Bühler; Victor Echeverry-Alzate; Stéphanie Giezendanner; E Giné; Lluis Montoliu; Rosario Moratalla; Pedro Olmos; Nicole A R Walter; Angel Santos; José Antonio López-Moreno
A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption.
Synapse (New York, N.Y.) 2013;67(6):280-9.
2013: Mónica Mártinez-García; Lluis Montoliu
Albinism in europe.
The Journal of dermatology 2013;40(5):319-24.
2012: Lluis Montoliu
Mendel: a simple excel workbook to compare the observed and expected distributions of genotypes/phenotypes in transgenic and knockout mouse crosses involving up to three unlinked loci by means of a χ2 test.
Transgenic research 2012;21(3):677-81.
2012: Maria Tiana; Diego Villar; Ana Fernández-Miñán; Laura Gómez-Maldonado; José Luis Gómez-Skarmeta; Eduardo Moltó; Lluis Montoliu; Eva Pérez-Guijarro; Luis del Peso
A role for insulator elements in the regulation of gene expression response to hypoxia.
Nucleic acids research 2012;40(5):1916-27.
2011: David Martin; Cristina Pantoja; Christian Valdes-Quezada; Eduardo Moltó; Fuencisla Matesanz; Ozren Bogdanović; Elisa de la Calle-Mustienes; Orlando Domínguez; Leila Taher; Mayra Furlan-Magaril; Antonio Alcina; Susana Cañón; María Fedetz; María A Blasco; Paulo S Pereira; Ivan Ovcharenko; Félix Recillas-Targa; Lluis Montoliu; Miguel Manzanares; Roderic Guigó; Manuel Serrano; Fernando Casares; Ana Fernández Miñán; José Luis Gómez-Skarmeta
Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes.
Nature structural & molecular biology 2011;18(6):708-14.
2011: Esther Zurita; Monica Chagoyen; Marta Cantero; Rosario Alonso; Anna González-Neira; Alejandro López-Jiménez; José Antonio López-Moreno; Carlisle P Landel; Javier Benítez; Florencio Pazos; Lluis Montoliu
Genetic polymorphisms among C57BL/6 mouse inbred strains.
Transgenic research 2011;20(3):481-9.
2011: Lluis Montoliu; C Bruce A Whitelaw
Using standard nomenclature to adequately name transgenes, knockout gene alleles and any mutation associated to a genetically modified mouse strain.
Transgenic research 2011;20(2):435-40.
2011: Angel Carlos Román; Francisco J González-Rico; Eduardo Moltó; Henar Hernando; Ana Neto; Cristina Vicente-Garcia; Esteban Ballestar; José L Gómez-Skarmeta; Jana Vavrova-Anderson; Robert J White; Lluis Montoliu; Pedro M Fernández-Salguero
Dioxin receptor and SLUG transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch.
Genome research 2011;21(3):422-32.
2011: Mayra Furlan-Magaril; Eria Rebollar; Georgina Guerrero; Almudena Fernández; Eduardo Moltó; Edgar González-Buendía; Marta Cantero; Lluis Montoliu; Félix Recillas-Targa
An insulator embedded in the chicken α-globin locus regulates chromatin domain configuration and differential gene expression.
Nucleic acids research 2011;39(1):89-103.
2010: Irene Soria-Castro; Agnieszka Krzyzanowska; Marta López Pelaéz; Javier Regadera; Gema Ferrer; Lluis Montoliu; Rosario Rodríguez-Ramos; Margarita Fernández; Susana Alemany
Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation.
The Journal of biological chemistry 2010;285(44):33805-15.
2010: Thomas J Fielder; Laura Barrios; Lluis Montoliu
A survey to establish performance standards for the production of transgenic mice.
Transgenic research 2010;19(4):675-81.
2010: Silvia Murillo-Cuesta; Julio Contreras; Esther Zurita; Rafael Cediel; Marta Cantero; Isabel Varela-Nieto; Lluis Montoliu
Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice.
Pigment cell & melanoma research 2010;23(1):72-83.
2010: Phil Wilkinson; Jitka Sengerova; Raffaele Matteoni; Chao-Kung Chen; Gaetan Soulat; Abel Ureta-Vidal; Sabine Fessele; Michael Hagn; Marzia Massimi; Karen Pickford; Richard H Butler; Susan Marschall; Ann-Marie Mallon; Amanda Pickard; Marcello Raspa; Ferdinando Scavizzi; Martin Fray; Vanessa Larrigaldie; Johan Leyritz; Ewan Birney; Glauco P Tocchini-Valentini; Steve Brown; Yann Herault; Lluis Montoliu; Martin Hrabé De Angelis; Damian Smedley
EMMA--mouse mutant resources for the international scientific community.
Nucleic acids research 2010;38(Database issue):D570-6.
2009: Lluis Montoliu
Compartir: a Spanish academic network initiative for sharing genetically modified mice.
Transgenic research 2009;18(6):829-30.
2009: Tokimasa Hida; Kazumasa Wakamatsu; Elena V Sviderskaya; Andrew J Donkin; Lluis Montoliu; M Lynn Lamoreux; Bin Yu; Glenn L Millhauser; Shosuke Ito; Gregory S Barsh; Kowichi Jimbow; Dorothy C Bennett
Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway.
Pigment cell & melanoma research 2009;22(5):623-34.
2009: José Bessa; Juan J Tena; Elisa de la Calle-Mustienes; Ana Fernández-Miñán; Silvia Naranjo; Almudena Fernández; Lluis Montoliu; Altuna Akalin; Boris Lenhard; Fernando Casares; José Luis Gómez-Skarmeta
Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(9):2409-17.
2009: Eduardo Moltó; Almudena Fernández; Lluis Montoliu
Boundaries in vertebrate genomes: different solutions to adequately insulate gene expression domains.
Briefings in functional genomics & proteomics 2009;8(4):283-96.
2009: Lluis Montoliu; Rosa Roy; Lucía Regales; Angel García-Díaz
Design of vectors for transgene expression: The use of genomic comparative approaches.
Comparative immunology, microbiology and infectious diseases 2009;32(2):81-90.
2007: James D Murray; Bruce Whitelaw; Lluis Montoliu
Meeting report: UC Davis Transgenic Animal Research Conference VI : Granlibakken Conference Center, Tahoe City, California, August 12-16, 2007.
Transgenic research 2007;16(6):835-7.
2007: Victoria Lunyak; Gratien Prefontaine; Esperanza Núñez; Thorsten Cramer; Bong-Gun Ju; Kenneth A Ohgi; Kasey R Hutt; Rosa Roy; Angel García-Díaz; Xiaoyan Zhu; Yun Yung; Lluis Montoliu; Christopher K Glass; Michael G Rosenfeld
Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis.
Science (New York, N.Y.) 2007;317(5835):248-51.
2007: Pedro N Moreira; Julio Pozueta; Miriam Pérez-Crespo; Fernando Valdivieso; Alfonso Gutierrez-Adan; Lluis Montoliu
Improving the generation of genomic-type transgenic mice by ICSI.
Transgenic research 2007;16(2):163-8.
2007: Pedro N Moreira; Miriam Pérez-Crespo; Miguel Angel Ramirez; Julio Pozueta; Lluis Montoliu; Alfonso Gutierrez-Adan
Effect of transgene concentration, flanking matrix attachment regions, and RecA-coating on the efficiency of mouse transgenesis mediated by intracytoplasmic sperm injection.
Biology of reproduction 2007;76(2):336-43.
2006: Alfonso Lavado; Glen Jeffery; Victoria Tovar; Pedro de la Villa; Lluis Montoliu
Ectopic expression of tyrosine hydroxylase in the pigmented epithelium rescues the retinal abnormalities and visual function common in albinos in the absence of melanin.
Journal of neurochemistry 2006;96(4):1201-11.
2006: Lluis Montoliu
Purification of Yeast Artificial Chromosome (YAC) DNA with Filtration Units.
CSH protocols 2006;2006(1):.
2006: Lluis Montoliu
Large-scale preparation of agarose plugs of yeast DNA.
CSH protocols 2006;2006(1):.
2006: Pedro N Moreira; Julio Pozueta; Patricia Giraldo; Alfonso Gutierrez-Adan; Lluis Montoliu
Generation of yeast artificial chromosome transgenic mice by intracytoplasmic sperm injection.
Methods in molecular biology (Clifton, N.J.) 2006;349():151-61.
2006: Alfonso Lavado; Lluis Montoliu
New animal models to study the role of tyrosinase in normal retinal development.
Frontiers in bioscience : a journal and virtual library 2006;11():743-52.
2005: Estela Giménez; Alfonso Lavado; Glen Jeffery; Lluis Montoliu
Regional abnormalities in retinal development are associated with local ocular hypopigmentation.
The Journal of comparative neurology 2005;485(4):338-47.
2005: Cruz Miguel Cendán; José Miguel Pujalte; Enrique Portillo-Salido; Lluis Montoliu; José M Baeyens
Formalin-induced pain is reduced in sigma(1) receptor knockout mice.
European journal of pharmacology 2005;511(1):73-4.
2005: Alfonso Lavado; Concepción Olivares; José C García-Borrón; Lluis Montoliu
Molecular basis of the extreme dilution mottled mouse mutation: a combination of coding and noncoding genomic alterations.
The Journal of biological chemistry 2005;280(6):4817-24.
2005: Eve Devinoy; Lluis Montoliu; Mária Baranyi; Dominique Thépot; László Hiripi; Marie-Louise Fontaine; Lilla Bodrogi; Zsuzsanna Bosze
Analysis of the efficiency of the rabbit whey acidic protein gene 5' flanking region in controlling the expression of homologous and heterologous linked genes.
The Journal of dairy research 2005;72 Spec No():113-9.
2005: Alfonso Lavado; Ander Matheu; Manuel Serrano; Lluis Montoliu
A strategy to study tyrosinase transgenes in mouse melanocytes.
BMC cell biology 2005;6(1):18.
2004: Pedro N Moreira; Patricia Giraldo; Patricia Cozar; Julio Pozueta; Adela Jiménez; Lluis Montoliu; Alfonso Gutierrez-Adan
Efficient generation of transgenic mice with intact yeast artificial chromosomes by intracytoplasmic sperm injection.
Biology of reproduction 2004;71(6):1943-7.
2004: Estela Giménez; Alfonso Lavado; Patricia Giraldo; Patricia Cozar; Glen Jeffery; Lluis Montoliu
A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2004;17(4):363-70.
2004: Lluis Montoliu; Lionel Larue; Friedrich Beermann
On the use of regulatory regions from pigmentary genes to drive the expression of transgenes in mice.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2004;17(2):188-90.
2003: Patricia Giraldo; Sylvie Rival-Gervier; Louis-Marie Houdebine; Lluis Montoliu
The potential benefits of insulators on heterologous constructs in transgenic animals.
Transgenic research 2003;12(6):751-5.
2003: Lucía Regales; Patricia Giraldo; Angel García-Díaz; Alfonso Lavado; Lluis Montoliu
Identification and functional validation of a 5' upstream regulatory sequence in the human tyrosinase gene homologous to the locus control region of the mouse tyrosinase gene.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2003;16(6):685-92.
2003: Estela Giménez; Alfonso Lavado; Patricia Giraldo; Lluis Montoliu
Tyrosinase gene expression is not detected in mouse brain outside the retinal pigment epithelium cells.
The European journal of neuroscience 2003;18(9):2673-6.
2003: Patricia Giraldo; Antonio Martínez; Lucía Regales; Alfonso Lavado; Angel García-Díaz; Angel Alonso; Ana Busturia; Lluis Montoliu
Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activity.
Nucleic acids research 2003;31(21):6290-305.
2003: Francina Langa; Xavier Codony; Victoria Tovar; Alfonso Lavado; Estela Giménez; Patricia Cozar; Marta Cantero; Alberto Dordal; Enric Hernández; Raquel Pérez; Xavier Monroy; Daniel Zamanillo; Xavier Guitart; Lluis Montoliu
Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice.
The European journal of neuroscience 2003;18(8):2188-96.
2003: Benjamin Millot; Lluis Montoliu; Marie-Louise Fontaine; Teresa Mata; Eve Devinoy
Hormone-induced modifications of the chromatin structure surrounding upstream regulatory regions conserved between the mouse and rabbit whey acidic protein genes.
The Biochemical journal 2003;372(Pt 1):41-52.
2003: Lluis Montoliu
Simple databases to monitor the generation and organisation of transgenic mouse colonies.
Transgenic research 2003;12(2):251-3.
2002: Patricia Giraldo; Lluis Montoliu
Artificial chromosome transgenesis in pigmentary research.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2002;15(4):258-64.
2002: Efren Riu; Alex Mas; Tura Ferre; Anna Pujol; Laurent Gros; Pedro J Otaegui; Lluis Montoliu; Fatima Bosch
Counteraction of type 1 diabetic alterations by engineering skeletal muscle to produce insulin: insights from transgenic mice.
Diabetes 2002;51(3):704-11.
2002: Lluis Montoliu
Gene transfer strategies in animal transgenesis.
Cloning and stem cells 2002;4(1):39-46.
2001: Estela Giménez; Patricia Giraldo; Glen Jeffery; Lluis Montoliu
Variegated expression and delayed retinal pigmentation during development in transgenic mice with a deletion in the locus control region of the tyrosinase gene.
Genesis (New York, N.Y. : 2000) 2001;30(1):21-5.
2001: Estela Giménez; Lluis Montoliu
A simple polymerase chain reaction assay for genotyping the retinal degeneration mutation (Pdeb(rd1)) in FVB/N-derived transgenic mice.
Laboratory animals 2001;35(2):153-6.
2001: Patricia Giraldo; Lluis Montoliu
Size matters: use of YACs, BACs and PACs in transgenic animals.
Transgenic research 2001;10(2):83-103.
2001: Brad A Rikke; Victoria J Simpson; Lluis Montoliu; Thomas Johnson
No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics.
Alcoholism, clinical and experimental research 2001;25(2):171-6.
2000: Lluis Montoliu; S Chávez; M Vidal
Variegation associated with lacZ in transgenic animals: a warning note.
Transgenic research 2000;9(3):237-9.
1999: Patricia Giraldo; Estela Giménez; Lluis Montoliu
The use of yeast artificial chromosomes in transgenic animals: expression studies of the tyrosinase gene in transgenic mice.
Genetic analysis : biomolecular engineering 1999;15(3-5):175-8.
1999: Laurent Gros; Efren Riu; Lluis Montoliu; M Ontiveros; L Lebrigand; Fatima Bosch
Insulin production by engineered muscle cells.
Human gene therapy 1999;10(7):1207-17.
1997: Laurent Gros; Lluis Montoliu; Efren Riu; L Lebrigand; Fatima Bosch
Regulated production of mature insulin by non-beta-cells.
Human gene therapy 1997;8(18):2249-59.
1997: Glen Jeffery; G Brem; Lluis Montoliu
Correction of retinal abnormalities found in albinism by introduction of a functional tyrosinase gene in transgenic mice and rabbits.
Brain research. Developmental brain research 1997;99(1):95-102.
1996: Lluis Montoliu; T Umland; Günther Schütz
A locus control region at -12 kb of the tyrosinase gene.
The EMBO journal 1996;15(22):6026-34.
1996: Gottfried Brem; Urban Besenfelder; Bernhard Aigner; Mathias Müller; I Liebl; G Schütz; Lluis Montoliu
YAC transgenesis in farm animals: rescue of albinism in rabbits.
Molecular reproduction and development 1996;44(1):56-62.
1996: Andreas Schedl; BR Grimes; Lluis Montoliu
YAC transfer by microinjection.
Methods in molecular biology (Clifton, N.J.) 1996;54():293-306.
1995: Lluis Montoliu; J A Blendy; T J Cole; Günther Schütz
Analysis of perinatal gene expression: hormone response elements mediate activation of a lacZ reporter gene in liver of transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4244-8.
1995: Lluis Montoliu; C T Bock; Günther Schütz; Hanswalter Zentgraf
Visualization of large DNA molecules by electron microscopy with polyamines: application to the analysis of yeast endogenous and artificial chromosomes.
Journal of molecular biology 1995;246(4):486-92.
1995: J A Blendy; T J Cole; Lluis Montoliu; Edith Hummler; R Ganss; A Aguzzi; Wolfgang Schmid; Günther Schütz
Molecular genetic analysis of cAMP and glucocorticoid signaling in development.
Recent progress in hormone research 1995;50():97-108.
1994: Glen Jeffery; G Schütz; Lluis Montoliu
Correction of abnormal retinal pathways found with albinism by introduction of a functional tyrosinase gene in transgenic mice.
Developmental biology 1994;166(2):460-4.
1994: Klaus kaestner; Lluis Montoliu; H Kern; M Thulke; Günther Schütz
Universal beta-galactosidase cloning vectors for promoter analysis and gene targeting.
Gene 1994;148(1):67-70.
1994: R Ganss; Lluis Montoliu; A Paula Monaghan; Günther Schütz
A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice.
The EMBO journal 1994;13(13):3083-93.
1994: Lluis Montoliu; J A Blendy; T J Cole; Günther Schütz
Analysis of the cAMP response on liver-specific gene expression in transgenic mice.
Fundamental & clinical pharmacology 1994;8(2):138-46.
1994: Lluis Montoliu; Andreas Schedl; G Kelsey; Hanswalter Zentgraf; Peter Lichter; Günther Schütz
Germ line transmission of yeast artificial chromosomes in transgenic mice.
Reproduction, fertility, and development 1994;6(5):577-84.
1993: Andreas Schedl; Z Larin; Lluis Montoliu; E Thies; G Kelsey; Hans Lehrach; Günther Schütz
A method for the generation of YAC transgenic mice by pronuclear microinjection.
Nucleic acids research 1993;21(20):4783-7.
1993: Andreas Schedl; Lluis Montoliu; G Kelsey; Günther Schütz
A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice.
Nature 1993;362(6417):258-61.
1993: Lluis Montoliu; Andreas Schedl; G Kelsey; Peter Lichter; Z Larin; Hans Lehrach; Günther Schütz
Generation of transgenic mice with yeast artificial chromosomes.
Cold Spring Harbor symposia on quantitative biology 1993;58():55-62.
1992: P Collazo; Lluis Montoliu; Pere Puigdomènech; Joan Rigau
Structure and expression of the lignin O-methyltransferase gene from Zea mays L.
Plant molecular biology 1992;20(5):857-67.
1992: Andreas Schedl; Friedrich Beermann; E Thies; Lluis Montoliu; G Kelsey; Günther Schütz
Transgenic mice generated by pronuclear injection of a yeast artificial chromosome.
Nucleic acids research 1992;20(12):3073-7.
1990: Lluis Montoliu; Joan Rigau; Pere Puigdomènech
Multiple polyadenylation sites are active in the alpha 1-tubulin gene from Zea mays.
FEBS letters 1990;277(1-2):29-32.
1990: Lluis Montoliu; Pere Puigdomènech; Joan Rigau
The Tub alpha 3 gene from Zea mays: structure and expression in dividing plant tissues.
Gene 1990;94(2):201-7.
1990: Lluis Montoliu; Joan Rigau; Pere Puigdomènech
A tandem of alpha-tubulin genes preferentially expressed in radicular tissues from Zea mays.
Plant molecular biology 1990;14(1):1-15.
1989: J Castellà-Escolà; Lluis Montoliu; G Pons; Pere Puigdomènech; M Cohen-Solal; José Carreras; Joan Rigau; F Climent
Sequence of rat skeletal muscle phosphoglycerate mutase cDNA.
Biochemical and biophysical research communications 1989;165(3):1345-51.