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Sergio Marchini

Research Profile

Anatomy

Tumor Cells, Cultured

Disorders

Ovarian Neoplasms

Chemicals & Drugs

Physiology

Living Beings

Procedures

Drug Screening Assays, Antitumor

Co-author Network

Publications

TOP 3
Sergio Marchini; Rodolfo Milani; Ilaria Fuso Nerini; Luca Porcu; Michela Romano; Chiara Romualdi; Mauro Signorelli; Valter Torri; Alberto Zambelli; Silvana di Giandomenico; Luca Beltrame; Giorgio Cattoretti; Duccio Cavalieri; giovanna chiorino; Luca Clivio; Robert Fruscio; Costantino Mangioni; Maurizio D'Incalci
Resistance to platinum-based chemotherapy is associated with epithelial to mesenchymal transition in epithelial ovarian cancer.
S Uboldi; A J Watson; S Di Giandomenico; S Bernasconi; A M Caccuri; O Capozzi; giovanna chiorino; L Clivio; Giovanna Damia; Eugenio Erba; A Fossati; I Fuso Nerini; M Ganzinelli; Federica Grosso; Roberto Mantovani; Elena Marangon; Sergio Marchini; G P Margison; A Pastore; M Rocchi; M Romano; F Sala; J C Tercero; Maurizio D'Incalci
Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents.
Sarah Uboldi; Luca Beltrame; Enrica Calura; Duccio Cavalieri; giovanna chiorino; Daniela D'Angelo; Maurizio D'Incalci; Eugenio Erba; Ilaria Fuso Nerini; Sergio Marchini; Paola Ostano; Chiara Romualdi
A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma.

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All Publications

2013: Sergio Marchini; Rodolfo Milani; Ilaria Fuso Nerini; Luca Porcu; Michela Romano; Chiara Romualdi; Mauro Signorelli; Valter Torri; Alberto Zambelli; Silvana di Giandomenico; Luca Beltrame; Giorgio Cattoretti; Duccio Cavalieri; giovanna chiorino; Luca Clivio; Robert Fruscio; Costantino Mangioni; Maurizio D'Incalci
Resistance to platinum-based chemotherapy is associated with epithelial to mesenchymal transition in epithelial ovarian cancer.
European journal of cancer (Oxford, England : 1990) 2013;49(2):520-30.
2012: S Uboldi; A J Watson; S Di Giandomenico; S Bernasconi; A M Caccuri; O Capozzi; giovanna chiorino; L Clivio; Giovanna Damia; Eugenio Erba; A Fossati; I Fuso Nerini; M Ganzinelli; Federica Grosso; Roberto Mantovani; Elena Marangon; Sergio Marchini; G P Margison; A Pastore; M Rocchi; M Romano; F Sala; J C Tercero; Maurizio D'Incalci
Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents.
International journal of cancer. Journal international du cancer 2012;131(1):59-69.
2012: Sarah Uboldi; Luca Beltrame; Enrica Calura; Duccio Cavalieri; giovanna chiorino; Daniela D'Angelo; Maurizio D'Incalci; Eugenio Erba; Ilaria Fuso Nerini; Sergio Marchini; Paola Ostano; Chiara Romualdi
A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma.
PloS one 2012;7(4):e35423.
2012: Rebecca A Mosig; Ravi Sachidanandam; Peter Schlosshauer; Emir Senturk; Hardik Shah; Samantha Cohen; Maurizio D'Incalci; PR Dottino; Robert Fruscio; Fei Huang; Li Lin; Sergio Marchini; John A Martignetti
Application of RNA-Seq transcriptome analysis: CD151 is an Invasion/Migration target in all stages of epithelial ovarian cancer.
Journal of ovarian research 2012;5():4.
2012: Rebecca A Mosig; Ravi Sachidanandam; Emir Senturk; Hardik Shah; Eugene Chudin; Samantha Cohen; Maurizio D'Incalci; PR Dottino; Robert Fruscio; Mollie Lobl; Sergio Marchini; John A Martignetti
IGFBP-4 tumor and serum levels are increased across all stages of epithelial ovarian cancer.
Journal of ovarian research 2012;5(1):3.
2009: Eleonora Marrazzo; Sergio Marchini; Michele Tavecchio; Tiziana Alberio; S Previdi; Eugenio Erba; V Rotter; Massimo Broggini
The expression of the DeltaNp73beta isoform of p73 leads to tetraploidy.
European journal of cancer (Oxford, England : 1990) 2009;45(3):443-53.
2008: Sergio Marchini; Pietro Mariani; giovanna chiorino; Eleonora Marrazzo; Riccardo Bonomi; Robert Fruscio; Luca Clivio; Annalisa Garbi; Valter Torri; Michela Cinquini; Tiziana Dell'Anna; Giovanni Apolone; Massimo Broggini; Maurizio D'Incalci
Analysis of gene expression in early-stage ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(23):7850-60.
2008: Sergio Marchini; Mirko Marabese; Eleonora Marrazzo; P Mariani; D Cattaneo; Roldano Fossati; A Compagnoni; Robert Fruscio; Andrea Lissoni; Massimo Broggini
DeltaNp63 expression is associated with poor survival in ovarian cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(3):501-7.
2008: Mirko Marabese; Sergio Marchini; Eleonora Marrazzo; Pietro Mariani; Dario Cattaneo; Roldano Fossati; Anna Compagnoni; Mauro Signorelli; Ute M Moll; Annamaria Codegoni; Massimo Broggini
Expression levels of p53 and p73 isoforms in stage I and stage III ovarian cancer.
European journal of cancer (Oxford, England : 1990) 2008;44(1):131-41.
2007: Teresa Rampino; Marilena Gregorini; cristina guidetti; Massimo Broggini; Sergio Marchini; Riccardo Bonomi; Milena Maggio; Elisabetta Roscini; Grazia Soccio; Renza Tiboldo; Antonio Dal Canton
KCNA1 and TRPC6 ion channels and NHE1 exchanger operate the biological outcome of HGF/scatter factor in renal tubular cells.
Growth factors (Chur, Switzerland) 2007;25(6):382-91.
2006: Eleonora Marrazzo; Sergio Marchini; Sara Previdi; Massimo Broggini
Questioning the oncogenic role of DeltaNp73alpha in different cell lines expressing p53 or not.
Cancer biology & therapy 2006;5(7):794-803.
2005: Mirko Marabese; Sergio Marchini; Maria Antonietta Sabatino; Federica Polato; Faina Vikhanskaya; Eleonora Marrazzo; Elena Riccardi; Eugenio Scanziani; Massimo Broggini
Effects of inducible overexpression of DNp73alpha on cancer cell growth and response to treatment in vitro and in vivo.
Cell death and differentiation 2005;12(7):805-14.
2005: Luigi Manenti; Elena Riccardi; Sergio Marchini; Elitza Naumova; Irene Floriani; Angela Garofalo; Romina Dossi; Eleonora Marrazzo; Dragana Vukasovic; Eugenio Scanziani; Maria Rosa Bani; Dorina Belotti; Massimo Broggini; Raffaella Giavazzi
Circulating plasma vascular endothelial growth factor in mice bearing human ovarian carcinoma xenograft correlates with tumor progression and response to therapy.
Molecular cancer therapeutics 2005;4(5):715-25.
2005: Sergio Marchini; Eleonora Marrazzo; R Bonomi; giovanna chiorino; Marco Zaffaroni; Lawrence Weissbach; Francis J Hornicek; Massimo Broggini; Glynn Faircloth; Maurizio D'Incalci
Molecular characterisation of two human cancer cell lines selected in vitro for their chemotherapeutic drug resistance to ET-743.
European journal of cancer (Oxford, England : 1990) 2005;41(2):323-33.
2004: Italo Beria; Pier Giovanni Baraldi; Paolo Cozzi; Marina Caldarelli; Cristina Geroni; Sergio Marchini; Nicola Mongelli; LUISA-CARLOTA LÓPEZ-CARA
Cytotoxic alpha-halogenoacrylic derivatives of distamycin A and congeners.
Journal of medicinal chemistry 2004;47(10):2611-23.
2004: Sergio Marchini; M D'Incalci; Massimo Broggini
New molecules and strategies in the field of anticancer agents.
Current medicinal chemistry. Anti-cancer agents 2004;4(3):247-62.
2004: Massimo Broggini; Sergio Marchini; Erminia Fontana; Donatella Moneta; Camilla Fowst; Cristina Geroni
Brostallicin: a new concept in minor groove DNA binder development.
Anti-cancer drugs 2004;15(1):1-6.
2003: Maria Antonietta Sabatino; Tina Colombo; Cristina Geroni; Sergio Marchini; Massimo Broggini
Enhancement of in vivo antitumor activity of classical anticancer agents by combination with the new, glutathione-interacting DNA minor groove-binder, brostallicin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(14):5402-8.
2003: André Fedier; Camilla Fowst; Jennifer Tursi; Cristina Geroni; Urs Haller; Sergio Marchini; Daniel Fink
Brostallicin (PNU-166196)--a new DNA minor groove binder that retains sensitivity in DNA mismatch repair-deficient tumour cells.
British journal of cancer 2003;89(8):1559-65.
2003: Dorina Belotti; Paola Paganoni; Luigi Manenti; Angela Garofalo; Sergio Marchini; Giulia Taraboletti; Raffaella Giavazzi
Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation.
Cancer research 2003;63(17):5224-9.
2003: Eugenio Erba; Marta Serafini; Giuseppe Gaipa; Gianluca Tognon; Sergio Marchini; Nicola Celli; Domenico Rotilio; Massimo Broggini; José Jimeno; Glynn Faircloth; Andrea Biondi; Maurizio D'Incalci
Effect of Aplidin in acute lymphoblastic leukaemia cells.
British journal of cancer 2003;89(4):763-73.
2003: Massimo Broggini; Sergio Marchini; Emanuela Galliera; Patrizia Borsotti; Giulia Taraboletti; Eugenio Erba; Marina Sironi; José Jimeno; Glynn Faircloth; Raffaella Giavazzi; Maurizio D'Incalci
Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4.
Leukemia 2003;17(1):52-9.
2002: Annamaria Biroccio; Barbara Benassi; Giuseppe Filomeni; Sarah Amodei; Sergio Marchini; giovanna chiorino; Giuseppe Rotilio; Gabriella Zupi; Maria Rosa Ciriolo
Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells.
The Journal of biological chemistry 2002;277(46):43763-70.
2002: Sergio Marchini; giovanna chiorino; Glynn Faircloth; Maurizio D'Incalci
Changes in gene expression profile induced by the anticancer agent Aplidine in Molt-4 leukemic cell lines.
Journal of biological regulators and homeostatic agents 2002;16(3):241-8.
2002: Cristina Geroni; Sergio Marchini; Paolo Cozzi; Emanuela Galliera; Enzio Ragg; Tina Colombo; Rosangela Battaglia; Martin Howard; Maurizio D'Incalci; Massimo Broggini
Brostallicin, a novel anticancer agent whose activity is enhanced upon binding to glutathione.
Cancer research 2002;62(8):2332-6.
2002: Maurizio D'Incalci; Eugenio Erba; Giovanna Damia; Emanuela Galliera; Laura Carrassa; Sergio Marchini; Roberto Mantovani; Gianluca Tognon; Robert Fruscio; José Jimeno; Glynn Faircloth
Unique features of the mode of action of ET-743.
The oncologist 2002;7(3):210-6.
2001: Sergio Marchini; Massimo Broggini; C Sessa; Maurizio D'Incalci
Development of distamycin-related DNA binding anticancer drugs.
Expert opinion on investigational drugs 2001;10(9):1703-14.
2001: Sergio Marchini; Giovanna Damia; Massimo Broggini; G Pennella; M Ripamonti; A Marsiglio; Cristina Geroni
4-Demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548), a novel anticancer agent active against tumor cell lines with different resistance mechanisms.
Cancer research 2001;61(5):1991-5.
2001: Cristina Geroni; M Ripamonti; C Arrigoni; francesco Fiorentini; L Capolongo; Donatella Moneta; Sergio Marchini; P Della Torre; C Albanese; M G Lamparelli; Marina Ciomei; R Rossi; M Caruso
Pharmacological and toxicological aspects of 4-demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548): a novel antineoplastic agent.
Cancer research 2001;61(5):1983-90.
2001: Faina Vikhanskaya; Sergio Marchini; Mirko Marabese; Emanuela Galliera; Massimo Broggini
P73a overexpression is associated with resistance to treatment with DNA-damaging agents in a human ovarian cancer cell line.
Cancer research 2001;61(3):935-8.
2000: Mario Minuzzo; Sergio Marchini; Massimo Broggini; Glynn Faircloth; Maurizio D'Incalci; Roberto Mantovani
Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6780-4.
1999: P Fullwood; Sergio Marchini; Janet S Rader; Alonso Martinez; Donia P Macartney; Massimo Broggini; Cristina Morelli; Giuseppe Barbanti-Brodano; Eamonn R Maher; Farida Latif
Detailed genetic and physical mapping of tumor suppressor loci on chromosome 3p in ovarian cancer.
Cancer research 1999;59(18):4662-7.
1999: Sergio Marchini; M Cirò; F Gallinari; Cristina Geroni; Paolo Cozzi; Maurizio D'Incalci; Massimo Broggini
Alpha-bromoacryloyl derivative of distamycin A (PNU 151807): a new non-covalent minor groove DNA binder with antineoplastic activity.
British journal of cancer 1999;80(7):991-7.
1999: G Colella; Sergio Marchini; Maurizio D'Incalci; R Brown; Massimo Broggini
Mismatch repair deficiency is associated with resistance to DNA minor groove alkylating agents.
British journal of cancer 1999;80(3-4):338-43.
1999: Sergio Marchini; M Ciro'; Massimo Broggini
P53-independent caspase-mediated apoptosis in human leukaemic cells is induced by a DNA minor groove binder with antineoplastic activity.
Apoptosis : an international journal on programmed cell death 1999;4(1):39-45.
1998: Sergio Marchini; Paolo Cozzi; Italo Beria; Cristina Geroni; L Capolongo; Maurizio D'Incalci; Massimo Broggini
Sequence-specific DNA alkylation of novel tallimustine derivatives.
Anti-cancer drug design 1998;13(3):193-205.
1997: Sergio Marchini; Annamaria Codegoni; Cristina Bonazzi; Stefania Chiari; Massimo Broggini
Absence of deletions but frequent loss of expression of p16INK4 in human ovarian tumours.
British journal of cancer 1997;76(2):146-9.
1995: Sergio Marchini; O Gonzalez Paz; M Ripamonti; Cristina Geroni; A Bargiotti; M Caruso; S Todeschi; Maurizio D'Incalci; Massimo Broggini
Sequence-specific DNA interactions by novel alkylating anthracycline derivatives.
Anti-cancer drug design 1995;10(8):641-53.