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Tom Chan

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Tom Chan; John X Wilson; Subajini Selliah; Marc Bilodeau; Claudia Zwingmann; Raymond Poon; Peter J O'Brien
Organochlorines inhibit acetaminophen glucuronidation by redirecting UDP-glucuronic acid towards the D-glucuronate pathway.
Nandita Shangari; Tom Chan; Katie Chan; Shuo Huai Wu; Peter J O'Brien
Copper-catalyzed ascorbate oxidation results in glyoxal/AGE formation and cytotoxicity.
Alison Li Lin; Nandita Shangari; Tom Chan; Diadelas Remirez; Peter J O'Brien
Herbal monoterpene alcohols inhibit propofol metabolism and prolong anesthesia time.

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All Publications

2008: Tom Chan; John X Wilson; Subajini Selliah; Marc Bilodeau; Claudia Zwingmann; Raymond Poon; Peter J O'Brien
Organochlorines inhibit acetaminophen glucuronidation by redirecting UDP-glucuronic acid towards the D-glucuronate pathway.
Toxicology and applied pharmacology 2008;232(3):456-62.
2007: Nandita Shangari; Tom Chan; Katie Chan; Shuo Huai Wu; Peter J O'Brien
Copper-catalyzed ascorbate oxidation results in glyoxal/AGE formation and cytotoxicity.
Molecular nutrition & food research 2007;51(4):445-55.
2006: Alison Li Lin; Nandita Shangari; Tom Chan; Diadelas Remirez; Peter J O'Brien
Herbal monoterpene alcohols inhibit propofol metabolism and prolong anesthesia time.
Life sciences 2006;79(1):21-9.
2006: Nandita Shangari; Tom Chan; marija popovic; Peter J O'Brien
Glyoxal markedly compromises hepatocyte resistance to hydrogen peroxide.
Biochemical pharmacology 2006;71(11):1610-8.
2006: Magdalena Dragan; S Jeffrey Dixon; Ewa Jaworski; Tom Chan; Peter J O'Brien; John X Wilson
Coenzyme Q(1) depletes NAD(P)H and impairs recycling of ascorbate in astrocytes.
Brain research 2006;1078(1):9-18.
2005: Tom Chan; Nandita Shangari; John X Wilson; Helen Chan; Roger F Butterworth; Peter J O'Brien
The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress.
Free radical biology & medicine 2005;38(7):867-73.
2005: Nandita Shangari; Tom Chan; Peter J O'Brien
Sulfation and glucuronidation of phenols: implications in coenyzme Q metabolism.
Methods in enzymology 2005;400():342-59.
2004: Arno G Siraki; Tom Chan; Peter J O'Brien
Application of quantitative structure-toxicity relationships for the comparison of the cytotoxicity of 14 p-benzoquinone congeners in primary cultured rat hepatocytes versus PC12 cells.
Toxicological sciences : an official journal of the Society of Toxicology 2004;81(1):148-59.
2004: Tom Chan; John X Wilson; Peter J O'Brien
Glycogenolysis is directed towards ascorbate synthesis by glutathione conjugation.
Biochemical and biophysical research communications 2004;317(1):149-56.
2004: Tom Chan; John X Wilson; Peter J O'Brien
Coenzyme Q cytoprotective mechanisms.
Methods in enzymology 2004;382():89-104.
2003: Mohammad Abdollahi; Tom Chan; Subrahmanyam Vangala; Peter J O'Brien
Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin.
Molecular and cellular biochemistry 2003;252(1-2):205-11.
2003: Tom Chan; Giuseppe Galati; Ananth S Pannala; Catherine Rice-Evans; Peter J O'Brien
Simultaneous detection of the antioxidant and pro-oxidant activity of dietary polyphenolics in a peroxidase system.
Free radical research 2003;37(7):787-94.
2003: Tom Chan; Peter J O'Brien
Hepatocyte metabolism of coenzyme Q1 (ubiquinone-5) to its sulfate conjugate decreases its antioxidant activity.
BioFactors (Oxford, England) 2003;18(1-4):207-18.
2002: Giuseppe Galati; Shahrzad Tafazoli; Omid Sabzevari; Tom Chan; Peter J O'Brien
Idiosyncratic NSAID drug induced oxidative stress.
Chemico-biological interactions 2002;142(1-2):25-41.
2002: Arno G Siraki; Tom Chan; Giuseppe Galati; Shirley Teng; Peter J O'Brien
N-oxidation of aromatic amines by intracellular oxidases.
Drug metabolism reviews 2002;34(3):549-64.
2002: Tom Chan; Shirley Teng; John X Wilson; Giuseppe Galati; Sumsallah Khan; Peter J O'Brien
Coenzyme Q cytoprotective mechanisms for mitochondrial complex I cytopathies involves NAD(P)H: quinone oxidoreductase 1(NQO1).
Free radical research 2002;36(4):421-7.
2002: Arno G Siraki; Jalal Pourahmad; Tom Chan; Sumsullah Khan; Peter J O'Brien
Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes.
Free radical biology & medicine 2002;32(1):2-10.
2001: A Sekher Pannala; Tom Chan; P J O'Brien; Catherine A Rice-Evans
Flavonoid B-ring chemistry and antioxidant activity: fast reaction kinetics.
Biochemical and biophysical research communications 2001;282(5):1161-8.
2001: Giuseppe Galati; Majid Y Moridani; Tom Chan; Peter J O'Brien
Peroxidative metabolism of apigenin and naringenin versus luteolin and quercetin: glutathione oxidation and conjugation.
Free radical biology & medicine 2001;30(4):370-82.
2001: Majid Y Moridani; Sumsullah Khan; Tom Chan; Shirley Teng; Kristin M Beard; Peter J O'Brien
Cytochrome P450 2E1 metabolically activates propargyl alcohol: propiolaldehyde-induced hepatocyte cytotoxicity.
Chemico-biological interactions 2001;130-132(1-3):931-42.
2001: Tom Chan; Majid Y Moridani; Arno G Siraki; Hugh Scobie; Kristin M Beard; Mohammad A Eghbal; Giuseppe Galati; Peter J O'Brien
Hydrogen peroxide supports hepatocyte P450 catalysed xenobiotic/drug metabolic activation to form cytotoxic reactive intermediates.
Advances in experimental medicine and biology 2001;500():233-6.
2000: Giuseppe Galati; Shirley Teng; Majid Y Moridani; Tom Chan; Peter J O'Brien
Cancer chemoprevention and apoptosis mechanisms induced by dietary polyphenolics.
Drug metabolism and drug interactions 2000;17(1-4):311-49.
1999: Tom Chan; Giuseppe Galati; Peter J O'Brien
Oxygen activation during peroxidase catalysed metabolism of flavones or flavanones.
Chemico-biological interactions 1999;122(1):15-25.
1999: G Galati; Tom Chan; B Wu; Peter J O'Brien
Glutathione-dependent generation of reactive oxygen species by the peroxidase-catalyzed redox cycling of flavonoids.
Chemical research in toxicology 1999;12(6):521-5.