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Yasuhiro Oki

Research Profile

Procedures

Antineoplastic Combined Chemotherapy Protocols

Physiology

DNA Methylation

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Yasuhiro Oki; Kaoru Tohyama; Akihiro Tomita; Naokuni Uike; Takashi Watanabe; Kazuhito Yamamoto; Tomomitsu Hotta; Masanobu Kasai; Yukio Kobayashi; Yutaka Kondo; Yasushi Miyazaki; Harumi Y Mukai; Michinori Ogura; Kazunori Ohnishi; Kazuma Ohyashiki; Shin-ichiro Okamoto; Masao Tomonaga
Phase I/II study of decitabine in patients with myelodysplastic syndrome: a multi-center study in Japan.
Yasuhiro Oki; Jorge Romaguera; Amanda Copeland; Michelle Fanale; Silvana de Castro Faria; Luis Fayad; Percy Ivy; L Jeffrey Medeiros; Anas Younes
Clinical experience with the heat shock protein-90 inhibitor, tanespimycin, in patients with relapsed lymphoma.
Yasuhiro Oki; Jorge Romaguera; Amanda Copeland; Michelle Fanale; Luis E Fayad; Fredrick Hagemeister; Anas Younes
Experience with obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist in patients with relapsed or refractory classical Hodgkin lymphoma.

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All Publications

2012: Yasuhiro Oki; Kaoru Tohyama; Akihiro Tomita; Naokuni Uike; Takashi Watanabe; Kazuhito Yamamoto; Tomomitsu Hotta; Masanobu Kasai; Yukio Kobayashi; Yutaka Kondo; Yasushi Miyazaki; Harumi Y Mukai; Michinori Ogura; Kazunori Ohnishi; Kazuma Ohyashiki; Shin-ichiro Okamoto; Masao Tomonaga
Phase I/II study of decitabine in patients with myelodysplastic syndrome: a multi-center study in Japan.
Cancer science 2012;103(10):1839-47.
2012: Yasuhiro Oki; Jorge Romaguera; Amanda Copeland; Michelle Fanale; Silvana de Castro Faria; Luis Fayad; Percy Ivy; L Jeffrey Medeiros; Anas Younes
Clinical experience with the heat shock protein-90 inhibitor, tanespimycin, in patients with relapsed lymphoma.
Leukemia & lymphoma 2012;53(5):990-2.
2012: Yasuhiro Oki; Jorge Romaguera; Amanda Copeland; Michelle Fanale; Luis E Fayad; Fredrick Hagemeister; Anas Younes
Experience with obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist in patients with relapsed or refractory classical Hodgkin lymphoma.
Blood 2012;119(9):2171-2.
2011: Anas Younes; L Jeffrey Medeiros; Sattva S Neelapu; Yasuhiro Oki; Tracy Patterson; Jessica K Paulus; M Renee Ward; Jeffrey M Besterman; R Gregory Bociek; Daniela Buglio; Amanda Copeland; Michel Drouin; Michelle Fanale; Ahmed Galal; Yuan Ji; John Kuruvilla; Zuomei Li; Robert E Martell
Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial.
The lancet oncology 2011;12(13):1222-8.
2011: Harumi Kato; Dai Chihara; Yoshitoyo Kagami; Yasuhiro Oki; Masao Seto; Hirofumi Taji; Kazuhito Yamamoto; Yasuo Morishima
Interstitial pneumonia after autologous hematopoietic stem cell transplantation in B-cell non-hodgkin lymphoma.
Clinical lymphoma, myeloma & leukemia 2011;11(6):483-9.
2011: Dai Chihara; Keitaro Matsuo; Yasuhiro Oki; Hiroshi Onoda; Hirofumi Taji; Kazuhito Yamamoto; Yasuo Morishima
Incidence and risk factors for central nervous system relapse in patients with diffuse large B-cell lymphoma: analyses with competing risk regression model.
Leukemia & lymphoma 2011;52(12):2270-5.
2011: Dai Chihara; Yasuhiro Oki; Hiroshi Onoda; Hirofumi Taji; Kazuhito Yamamoto; Tsuneo Tamaki; Yasuo Morishima
High maximum standard uptake value (SUVmax) on PET scan is associated with shorter survival in patients with diffuse large B cell lymphoma.
International journal of hematology 2011;93(4):502-8.
2010: Marcos R H Estécio; Juan Gallegos; Céline Vallot; Ryan J Castoro; Woonbok Chung; Shinji Maegawa; Yasuhiro Oki; Yutaka Kondo; Jaroslav Jelinek; Lanlan Shen; Helge Hartung; Peter D Aplan; Bogdan A Czerniak; Shoudan Liang; Jean-Pierre J Issa
Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer.
Genome research 2010;20(10):1369-82.
2010: H Kato; Kazuhito Yamamoto; Keitaro Matsuo; Yasuhiro Oki; Hirofumi Taji; Yachiyo Kuwatsuka; Masao Seto; Yoshitoyo Kagami; Yasuo Morishima
Clinical impact and predisposing factors of delayed-onset neutropenia after autologous hematopoietic stem-cell transplantation for B-cell non-Hodgkin lymphoma: association with an incremental risk of infectious events.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2010;21(8):1699-705.
2010: Yasuhiro Oki; Anas Younes
Does rituximab have a place in treating classic hodgkin lymphoma?
Current hematologic malignancy reports 2010;5(3):135-9.
2010: Dai Chihara; Yasuhiro Oki; Shouji Ine; Harumi Kato; Hiroshi Onoda; Hirofumi Taji; Yoshitoyo Kagami; Kazuhito Yamamoto; Yasuo Morishima
Primary gastric diffuse large B-cell Lymphoma (DLBCL): analyses of prognostic factors and value of pretreatment FDG-PET scan.
European journal of haematology 2010;84(6):493-8.
2010: Lanlan Shen; Andrew Lamb; Yi Guo; Edward Lin; Jianqin Shan; Xuelin Huang; Donald Berry; Saira Ahmed; Wei Zhu; Sherry Pierce; Yutaka Kondo; Yasuhiro Oki; Jaroslav Jelinek; Hussain Saba; Eli Estey; Jean-Pierre J Issa
DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(4):605-13.
2010: Yasuhiro Oki; Jean-Pierre J Issa
Epigenetic mechanisms in AML - a target for therapy.
Cancer treatment and research 2010;145():19-40.
2010: Dai Chihara; Yoshitoyo Kagami; Yasuhiro Oki; Harumi Kato; Hiroshi Onoda; Shouji Ine; Hirofumi Taji; Kazuhito Yamamoto; Yasuo Morishima
R-CHOP therapy for MALT lymphoma of the rectum.
European journal of haematology 2010;84(1):84-6.
2009: Harumi Kato; Hirofumi Taji; Michinori Ogura; Yoshitoyo Kagami; Yasuhiro Oki; Akane Tsujimura; Nobukazu Fuwa; Takeshi Kodaira; Masao Seto; Kazuhito Yamamoto; Yasuo Morishima
Favorable consolidative effect of high-dose melphalan and total-body irradiation followed by autologous peripheral blood stem cell transplantation after rituximab-containing induction chemotherapy with in vivo purging in relapsed or refractory follicular lymphoma.
Clinical lymphoma & myeloma 2009;9(6):443-8.
2009: Dai Chihara; Yasuhiro Oki; Shouji Ine; Kazuhito Yamamoto; Harumi Kato; Hirofumi Taji; Yoshitoyo Kagami; Yasushi Yatabe; Shigeo Nakamura; Yasuo Morishima
Analysis of prognostic factors in peripheral T-cell lymphoma: prognostic value of serum albumin and mediastinal lymphadenopathy.
Leukemia & lymphoma 2009;50(12):1999-2004.
2009: Michael Wang; Yasuhiro Oki; Barbara Pro; Jorge Romaguera; Maria Alma Rodriguez; Felipe Samaniego; Peter McLaughlin; Fredrick Hagemeister; Sattva S Neelapu; Amanda Copeland; Barry Samuels; Evelyne M Loyer; Yuan Ji; Anas Younes
Phase II study of yttrium-90-ibritumomab tiuxetan in patients with relapsed or refractory mantle cell lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(31):5213-8.
2009: David J Stewart; Jean-Pierre J Issa; Razelle Kurzrock; Maria I Nunez; Jaroslav Jelinek; David Hong; Yasuhiro Oki; Zhong Guo; Sanjay Gupta; Ignacio I Wistuba
Decitabine effect on tumor global DNA methylation and other parameters in a phase I trial in refractory solid tumors and lymphomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(11):3881-8.
2008: Yasuhiro Oki; Kazuhito Yamamoto; Harumi Kato; Yachiyo Kuwatsuka; Hirofumi Taji; Yoshitoyo Kagami; Yasuo Morishima
Low absolute lymphocyte count is a poor prognostic marker in patients with diffuse large B-cell lymphoma and suggests patients' survival benefit from rituximab.
European journal of haematology 2008;81(6):448-53.
2008: Yasuhiro Oki; Harumi Kato; Keitaro Matsuo; Yachiyo Kuwatsuka; Hirofumi Taji; Kazuhito Yamamoto; Yoshitoyo Kagami; Yasuo Morishima
Prognostic value of serum soluble interleukin-2 receptor level in patients with diffuse large B cell lymphoma, treated with CHOP- or RCHOP-based therapy.
Leukemia & lymphoma 2008;49(7):1345-51.
2008: Yasuhiro Oki; Anas Younes
Current role of gemcitabine in the treatment of Hodgkin lymphoma.
Leukemia & lymphoma 2008;49(5):883-9.
2008: Yasuhiro Oki; Barbara Pro; Luis Fayad; Jorge Romaguera; Felipe Samaniego; Fredrick Hagemeister; Sattva S Neelapu; Peter McLaughlin; Andre Goy; Anas Younes
Phase 2 study of gemcitabine in combination with rituximab in patients with recurrent or refractory Hodgkin lymphoma.
Cancer 2008;112(4):831-6.
2008: Yasuhiro Oki; Jaroslav Jelinek; Lanlan Shen; Hagop M Kantarjian; Jean-Pierre J Issa
Induction of hypomethylation and molecular response after decitabine therapy in patients with chronic myelomonocytic leukemia.
Blood 2008;111(4):2382-4.
2008: Yasuhiro Oki; Michinori Ogura; Harumi Kato; Ako Kikuchi; Hirofumi Taji; Yoshitoyo Kagami; Aya Oshiro; Akane Tsujimura; Kazuhito Yamamoto; Yasuo Morishima
Phase II study of a salvage regimen using cyclophosphamide, high-dose cytarabine, dexamethasone, etoposide, and rituximab in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma.
Cancer science 2008;99(1):179-84.
2007: Yasuhiro Oki; Jean-Pierre J Issa
Treatment options in advanced myelodysplastic syndrome, with emphasis on epigenetic therapy.
International journal of hematology 2007;86(4):306-14.
2007: Yasuhiro Oki; Georgios V Georgakis; Thi-Sau Migone; Larry W Kwak; Anas Younes
Elevated serum BLyS levels in patients with non-Hodgkin lymphoma.
Leukemia & lymphoma 2007;48(9):1869-71.
2007: Xuelin Huang; Swati Biswas; Yasuhiro Oki; Jean-Pierre J Issa; Donald A Berry
A parallel phase I/II clinical trial design for combination therapies.
Biometrics 2007;63(2):429-36.
2007: Yasuhiro Oki; Anas Younes
Endothelial progenitor cells in non-Hodgkin's lymphoma.
Haematologica 2007;92(4):433-4.
2007: Yasuhiro Oki; Hagop M Kantarjian; Vazganush Gharibyan; Dan Jones; Susan O'Brien; Srdan Verstovsek; Jorge Cortes; Gail M Morris; Guillermo Garcia-Manero; Jean-Pierre J Issa
Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia.
Cancer 2007;109(5):899-906.
2007: Yasuhiro Oki; Georgios V Georgakis; Thi-Sau Migone; Larry W Kwak; Anas Younes
Prognostic significance of serum B-lymphocyte stimulator in Hodgkin's lymphoma.
Haematologica 2007;92(2):269-70.
2007: Yasuhiro Oki; Etsuko Aoki; Jean-Pierre J Issa
Decitabine--bedside to bench.
Critical reviews in oncology/hematology 2007;61(2):140-52.
2007: Yasuhiro Oki; Peter McLaughlin; Luis Fayad; Barbara Pro; Paul F Mansfield; Gary L Clayman; L Jeffrey Medeiros; Larry W Kwak; Pramod K Srivastava; Anas Younes
Experience with heat shock protein-peptide complex 96 vaccine therapy in patients with indolent non-Hodgkin lymphoma.
Cancer 2007;109(1):77-83.
2007: Andrew Lamb; Yasuhiro Oki; Guillermo Garcia-Manero; Xuelin Huang; Susan O'Brien; Jorge Cortes; Stefan Faderl; Carlos E Bueso-Ramos; Farhad Ravandi; Zeev Estrov; Alessandra Ferrajoli; William Wierda; Jianqin Shan; Jan Davis; Francis Giles; Hussain I Saba; Jean-Pierre J Issa
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia.
Blood 2007;109(1):52-7.
2006: Yasuhiro Oki; Jaroslav Jelinek; Miloslav Beran; Srdan Verstovsek; Hagop M Kantarjian; Jean-Pierre J Issa
Mutations and promoter methylation status of NPM1 in myeloproliferative disorders.
Haematologica 2006;91(8):1147-8.
2006: Jingmin Shu; Jaroslav Jelinek; Hao Chang; Lanlan Shen; Taichun Qin; Woonbok Chung; Yasuhiro Oki; Jean-Pierre J Issa
Silencing of bidirectional promoters by DNA methylation in tumorigenesis.
Cancer research 2006;66(10):5077-84.
2006: Yasuhiro Oki; Jean-Pierre J Issa
Review: recent clinical trials in epigenetic therapy.
Reviews on recent clinical trials 2006;1(2):169-82.
2006: Yasuhiro Oki; Hagop M Kantarjian; Xian Zhou; Jorge Cortes; Stefan Faderl; Srdan Verstovsek; Susan O'Brien; Charles Koller; Miloslav Beran; B Nebiyou Bekele; Sherry Pierce; Deborah Thomas; Farhad Ravandi; William G Wierda; Francis Giles; Alessandra Ferrajoli; Elias Jabbour; Michael J Keating; Carlos E Bueso-Ramos; Elihu Estey; Guillermo Garcia-Manero
Adult acute megakaryocytic leukemia: an analysis of 37 patients treated at M.D. Anderson Cancer Center.
Blood 2006;107(3):880-4.
2005: Jaroslav Jelinek; Yasuhiro Oki; Vazganush Gharibyan; Carlos E Bueso-Ramos; Josef T Prchal; Srdan Verstovsek; Miloslav Beran; Elihu Estey; Hagop M Kantarjian; Jean-Pierre J Issa
JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia.
Blood 2005;106(10):3370-3.
2005: Yasuhiro Oki; Peter McLaughlin; Barbara Pro; Fredrick B Hagemeister; Archie Bleyer; Evelyne M Loyer; Anas Younes
Phase II study of oxaliplatin in patients with recurrent or refractory non-Hodgkin lymphoma.
Cancer 2005;104(4):781-7.
2004: Yasuhiro Oki; Anas Younes
Heat shock protein-based cancer vaccines.
Expert review of vaccines 2004;3(4):403-11.
2002: Masahiro Kami; Yukiko Kishi; Tamae Hamaki; M Kawabata; Takeshi Kashima; T Masumoto; Yasuhiro Oki; Yuji Tanaka; S Sawada; Utako Machida; K Ohtomo; Yoshinobu Kanda; Hisamura Hirai; Yoshitomo Mutou
The value of the chest computed tomography halo sign in the diagnosis of invasive pulmonary aspergillosis. An autopsy-based retrospective study of 48 patients.
Mycoses 2002;45(8):287-94.
2001: Yukiko Kishi; Masahiro Kami; Yasuhiro Oki; Tamae Hamaki; Yoshinobu Kanda; Utako Machida; Shigesaburo Miyakoshi; Jun-ichi Ueyama; Shinichi Morinaga; Yoshitomo Muto
Successful bone marrow transplantation for adult T-cell leukemia from a donor with oligoclonal proliferation of T-cells infected with human T-cell lymphotropic virus.
Leukemia & lymphoma 2001;42(4):819-22.
2001: Yasuhiro Oki; Masahiro Kami; Y Kishi; Jun-ichi Ueyama; S Honma; T Sugiyama; Shigesaburo Miyakoshi; Y Kanda; Shinichi Morinaga; Y Muto
Pneumocystis carinii pneumonia with an atypical granulomatous response in a patient with chronic lymphocytic leukemia.
Leukemia & lymphoma 2001;41(3-4):435-8.
2001: Shigeo Hara; Masahiro Kami; Shigesaburo Miyakoshi; R Suzuki; Kengo Takeuchi; T Seki; Yasuhiro Oki; Yukiko Kishi; Shinichi Morinaga; Yoshitomo Mutou
Central nervous system involvement in pyothorax-associated lymphoma: ring enhancement on CT scan.
Annals of hematology 2001;80(3):174-7.
2001: Y Kishi; Masahiro Kami; M Kogi; Yasuhiro Oki; Utako Machida; Y Kanda; Jun-ichi Ueyama; Shinichi Morinaga; Y Muto
A limitation of fluorescence in situ hybridization (FISH) assays targeting sex chromosomes for monitoring of early relapse after transplantation.
Transplantation 2001;71(4):581-3.