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Patrick Augustijns

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Tom De Bruyn; Sarinj Fattah; Janneke Keemink; Johan Nicolaï; Patrick Augustijns; Sagnik Chatterjee; Pieter Annaert
Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity.
Nico Holmstock; Pieter Annaert; Myriam Baes; Frank J Gonzalez; Patrick Augustijns
PXR/CYP3A4-humanized mice for studying drug-drug interactions involving intestinal P-glycoprotein.
Randy Mellaerts; Mickaël Rivallan; Frédéric Thibault-Starzyk; Guy Van den Mooter; Patrick Augustijns; Elie J Fayad; Johan A Martens
In situ FT-IR investigation of etravirine speciation in pores of SBA-15 ordered mesoporous silica material upon contact with water.

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2013: Tom De Bruyn; Sarinj Fattah; Janneke Keemink; Johan Nicolaï; Patrick Augustijns; Sagnik Chatterjee; Pieter Annaert
Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity.
Expert opinion on drug metabolism & toxicology 2013;9(5):589-616.
2013: Nico Holmstock; Pieter Annaert; Myriam Baes; Frank J Gonzalez; Patrick Augustijns
PXR/CYP3A4-humanized mice for studying drug-drug interactions involving intestinal P-glycoprotein.
Molecular pharmaceutics 2013;10(3):1056-62.
2013: Randy Mellaerts; Mickaël Rivallan; Frédéric Thibault-Starzyk; Guy Van den Mooter; Patrick Augustijns; Elie J Fayad; Johan A Martens
In situ FT-IR investigation of etravirine speciation in pores of SBA-15 ordered mesoporous silica material upon contact with water.
Molecular pharmaceutics 2013;10(2):567-73.
2012: Carolien Grammen; Patrick Augustijns; Joachim Brouwers
In vitro profiling of the vaginal permeation potential of anti-HIV microbicides and the influence of formulation excipients.
Antiviral research 2012;96(2):226-33.
2012: Jan Bevernage; Joachim Brouwers; Pieter Annaert; Patrick Augustijns
Drug precipitation-permeation interplay: supersaturation in an absorptive environment.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2012;82(2):424-8.
2012: Michiel Van Speybroeck; Hywel D Williams; Mette U Anby; Tri-Hung Nguyen; Christopher J H Porter; Patrick Augustijns
Incomplete desorption of liquid excipients reduces the in vitro and in vivo performance of self-emulsifying drug delivery systems solidified by adsorption onto an inorganic mesoporous carrier.
Molecular pharmaceutics 2012;9(9):2750-60.
2012: Nico Holmstock; Pieter Annaert; Patrick Augustijns
Boosting of HIV protease inhibitors by ritonavir in the intestine: the relative role of cytochrome P450 and P-glycoprotein inhibition based on Caco-2 monolayers versus in situ intestinal perfusion in mice.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(8):1473-7.
2012: Gul Shahnaz; Anja Vetter; Patrick Augustijns; Jan Barthelmes; Sarah Dünnhaput; Javed Iqbal; Flavia Laffleur; Glen Perera; Deni Rahmat; Wolfgang Schlocker; Andreas Bernkop-Schnürch
Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization.
International journal of pharmaceutics 2012;428(1-2):164-70.
2012: Jan Bevernage; Joachim Brouwers; Bart Hens; Jan Tack; Pieter Annaert; Patrick Augustijns
Supersaturation in human gastric fluids.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2012;81(1):184-9.
2012: Andrea Gorlani; Karl Malcolm; Christopher McConville; Anna Forsman Quigley; Pieter van der Bijl; Patrick Augustijns; Joachim Brouwers; Hans de Haard; Robin Weiss; Theo Verrips
Llama antibody fragments have good potential for application as HIV type 1 topical microbicides.
AIDS research and human retroviruses 2012;28(2):198-205.
2012: Nathalie Dereuddre-Bosquet; Carolina Herrera; Leo Heyndrickx; Pascal Kessler; Roger Le Grand; Laurence Morellato-Castillo; Gilles Ponchel; Oscar H P Ramos; Robin Shattock; Martha Stefanidou; Guido Vanham; Patrick Augustijns; Kawthar Bouchemal; Joachim Brouwers; Loïc Martin
MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques.
PLoS pathogens 2012;8(12):e1003071.
2012: Tom De Bruyn; Pieter Evenepoel; Ruth Laub; Björn Meijers; Ludo Willems; Patrick Augustijns; Pieter Annaert
Stability of therapeutic albumin solutions used for molecular adsorbent recirculating system-based liver dialysis.
Artificial organs 2012;36(1):29-41.
2012: Patrick Augustijns; Marcus E Brewster
Supersaturating drug delivery systems: fast is not necessarily good enough.
Journal of pharmaceutical sciences 2012;101(1):7-9.
2011: Thomas F Palmberger; Anja Vetter; Patrick Augustijns; Andreas Bernkop-Schnürch
Safety assessment of thiolated polymers: effect on ciliary beat frequency in human nasal epithelial cells.
Drug development and industrial pharmacy 2011;37(12):1455-62.
2011: Jeroen Walravens; Pieter Annaert; Joachim Brouwers; Isabel Spriet; Jan Tack; Patrick Augustijns
Effect of pH and comedication on gastrointestinal absorption of posaconazole: monitoring of intraluminal and plasma drug concentrations.
Clinical pharmacokinetics 2011;50(11):725-34.
2011: Tom De Bruyn; Sarinj Fattah; Bruno Stieger; Patrick Augustijns; Pieter Annaert
Sodium fluorescein is a probe substrate for hepatic drug transport mediated by OATP1B1 and OATP1B3.
Journal of pharmaceutical sciences 2011;100(11):5018-30.
2011: Michiel Van Speybroeck; Pieter Annaert; Johan A Martens; Randy Mellaerts; Thao Do Thi; Guy Van den Mooter; Jan Van Humbeeck; Patrick Augustijns
Preventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidic drugs.
Journal of pharmaceutical sciences 2011;100(11):4864-76.
2011: Joachim Brouwers; Carolien Grammen; Dominique Schols; Kurt Vermeire; Patrick Augustijns
Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir.
Antiviral research 2011;91(2):217-23.
2011: Thao Thi Do; Johan Martens; Raf Mols; Pieter Annaert; Patrick Augustijns; Jan Van Humbeeck; Michiel Van Speybroeck; Jan Vermant; Guy Van den Mooter
The conflict between in vitro release studies in human biorelevant media and the in vivo exposure in rats of the lipophilic compound fenofibrate.
International journal of pharmaceutics 2011;414(1-2):118-24.
2011: Sarah Clarysse; Jan Tack; Pieter Annaert; Joachim Brouwers; Patrick Augustijns
Intestinal drug solubility estimation based on simulated intestinal fluids: comparison with solubility in human intestinal fluids.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011;43(4):260-9.
2011: Souzan B Yanni; P Brian Smith; Daniel K Benjamin; Patrick Augustijns; Dhiren R Thakker; Pieter Annaert
Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding.
Biopharmaceutics & drug disposition 2011;32(4):222-32.
2011: Jan Bevernage; Thomas Forier; Joachim Brouwers; Jan Tack; Pieter Annaert; Patrick Augustijns
Excipient-mediated supersaturation stabilization in human intestinal fluids.
Molecular pharmaceutics 2011;8(2):564-70.
2011: Teemu Heikkilä; Milja Karjalainen; Krista Ojala; Kirsi Partola; Frank Lammert; Patrick Augustijns; Arto Urtti; Marjo Yliperttula; Leena Peltonen; Jouni Hirvonen
Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6.8 and human intestinal fluid.
International journal of pharmaceutics 2011;405(1-2):132-6.
2011: Randy Mellaerts; Maarten B J Roeffaers; Kristof Houthoofd; Michiel Van Speybroeck; Gert De Cremer; Jasper A G Jammaer; Guy Van den Mooter; Patrick Augustijns; Johan Hofkens; Johan A Martens
Molecular organization of hydrophobic molecules and co-adsorbed water in SBA-15 ordered mesoporous silica material.
Physical chemistry chemical physics : PCCP 2011;13(7):2706-13.
2011: Joachim Brouwers; Bart Anneveld; Gert-Jan Goudappel; Guus S Duchateau; Pieter Annaert; Patrick Augustijns; Evelijn Zeijdner
Food-dependent disintegration of immediate release fosamprenavir tablets: in vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;77(2):313-9.
2010: Michiel Van Speybroeck; Randy Mellaerts; Raf Mols; Thao Do Thi; Johan A Martens; Jan Van Humbeeck; Pieter Annaert; Guy Van den Mooter; Patrick Augustijns
Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2010;41(5):623-30.
2010: Youssef Gali; Olivier Delezay; Joachim Brouwers; Noura Addad; Patrick Augustijns; Thomas Bourlet; Hind Hamzeh-Cognasse; Kevin K Ariën; Bruno POZZETTO; Guido Vanham
In vitro evaluation of viability, integrity, and inflammation in genital epithelia upon exposure to pharmaceutical excipients and candidate microbicides.
Antimicrobial agents and chemotherapy 2010;54(12):5105-14.
2010: Jan Bevernage; Joachim Brouwers; Sarah Clarysse; Maria Vertzoni; Jan Tack; Pieter Annaert; Patrick Augustijns
Drug supersaturation in simulated and human intestinal fluids representing different nutritional states.
Journal of pharmaceutical sciences 2010;99(11):4525-34.
2010: Bernard Van Eerdenbrugh; Jan Vermant; Ludo Froyen; Jan Van Humbeeck; Johan A Martens; Guy Van den Mooter; Patrick Augustijns
Solubility increases associated with crystalline drug nanoparticles: methodologies and significance.
Molecular pharmaceutics 2010;7(5):1858-70.
2010: Souzan B Yanni; Patrick Augustijns; Daniel K Benjamin; Kim L R Brouwer; Dhiren R Thakker; Pieter Annaert
In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(10):1848-56.
2010: C A Aerts; E Verraedt; A Depla; L Follens; L Froyen; J Van Humbeeck; Patrick Augustijns; Guy Van den Mooter; R Mellaerts; Johan A Martens
Potential of amorphous microporous silica for ibuprofen controlled release.
International journal of pharmaceutics 2010;397(1-2):84-91.
2010: Thao Do Thi; Koen Nauwelaerts; Matheus Froeyen; Luc Baudemprez; Michiel Van Speybroeck; Patrick Augustijns; Pieter Annaert; Johan Martens; Jan Van Humbeeck; Guy Van den Mooter
Comparison of the complexation between methylprednisolone and different cyclodextrins in solution by 1H-NMR and molecular modeling studies.
Journal of pharmaceutical sciences 2010;99(9):3863-73.
2010: Nico Holmstock; Raf Mols; Pieter Annaert; Patrick Augustijns
In situ intestinal perfusion in knockout mice demonstrates inhibition of intestinal p-glycoprotein by ritonavir causing increased darunavir absorption.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(9):1407-10.
2010: Bram Slütter; Suzanne Bal; Chantal Keijzer; Roel Mallants; Niels Hagenaars; Ivo Que; Eric Kaijzel; Willem van Eden; Patrick Augustijns; Clemens W G M Löwik; Joke Bouwstra; Femke Broere; Wim Jiskoot
Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen.
Vaccine 2010;28(38):6282-91.
2010: Jurgen Mensch; Libuse Jaroskova; Wendy Sanderson; Anouche Melis; Claire Mackie; Geert Verreck; Marcus E Brewster; Patrick Augustijns
Application of PAMPA-models to predict BBB permeability including efflux ratio, plasma protein binding and physicochemical parameters.
International journal of pharmaceutics 2010;395(1-2):182-97.
2010: Michiel Van Speybroeck; Raf Mols; Randy Mellaerts; Thao Do Thi; Johan A Martens; Jan Van Humbeeck; Pieter Annaert; Guy Van den Mooter; Patrick Augustijns
Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2010;75(3):354-65.
2010: Peter Suenaert; Philippe Maerten; Gert van Assche; Willy Van Driessche; Karel Geboes; Veerle Bulteel; Jeannine Simaels; Patrick Augustijns; Jan L Ceuppens; Paul Rutgeerts; Clémentine Perrier
Effects of T cell-induced colonic inflammation on epithelial barrier function.
Inflammatory bowel diseases 2010;16(8):1322-31.
2010: Joachim Brouwers; Raf Mols; Pieter Annaert; Patrick Augustijns
Validation of a differential in situ perfusion method with mesenteric blood sampling in rats for intestinal drug interaction profiling.
Biopharmaceutics & drug disposition 2010;31(5-6):278-85.
2010: Randy Mellaerts; Alexander Aerts; Tom P Caremans; Jan Vermant; Guy Van den Mooter; Johan A Martens; Patrick Augustijns
Growth of itraconazole nanofibers in supersaturated simulated intestinal fluid.
Molecular pharmaceutics 2010;7(3):905-13.
2010: Zhi-wei Ye; Jos van Pelt; Sandrine Camus; Jan Snoeys; Patrick Augustijns; Pieter Annaert
Species-specific interaction of HIV protease inhibitors with accumulation of cholyl-glycylamido-fluorescein (CGamF) in sandwich-cultured hepatocytes.
Journal of pharmaceutical sciences 2010;99(6):2886-98.
2010: Zhi-Wei Ye; Sandrine Camus; Patrick Augustijns; Pieter Annaert
Interaction of eight HIV protease inhibitors with the canalicular efflux transporter ABCC2 (MRP2) in sandwich-cultured rat and human hepatocytes.
Biopharmaceutics & drug disposition 2010;31(2-3):178-88.
2010: Pieter Annaert; Z W Ye; B Stieger; Patrick Augustijns
Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1.
Xenobiotica; the fate of foreign compounds in biological systems 2010;40(3):163-76.
2010: Jurgen Mensch; Anouche Melis; Claire Mackie; Geert Verreck; Marcus E Brewster; Patrick Augustijns
Evaluation of various PAMPA models to identify the most discriminating method for the prediction of BBB permeability.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2010;74(3):495-502.
2010: Pieter Annaert; Joachim Brouwers; Ann Bijnens; Frank Lammert; Jan Tack; Patrick Augustijns
Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2010;39(1-3):15-22.
2010: Souzan B Yanni; Pieter Annaert; Patrick Augustijns; Joseph G Ibrahim; Daniel K Benjamin; Dhiren R Thakker
In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(1):25-31.
2009: Thao Do Thi; Michiel Van Speybroeck; Valery Barillaro; Johan Martens; Pieter Annaert; Patrick Augustijns; Jan Van Humbeeck; Jan Vermant; Guy Van den Mooter
Formulate-ability of ten compounds with different physicochemical profiles in SMEDDS.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;38(5):479-88.
2009: Jurgen Mensch; Julen Oyarzabal; Claire Mackie; Patrick Augustijns
In vivo, in vitro and in silico methods for small molecule transfer across the BBB.
Journal of pharmaceutical sciences 2009;98(12):4429-68.
2009: Bernard Van Eerdenbrugh; Michiel Van Speybroeck; Raf Mols; Kristof Houthoofd; Johan A Martens; Ludo Froyen; Jan Van Humbeeck; Patrick Augustijns; Guy Van den Mooter
Itraconazole/TPGS/Aerosil200 solid dispersions: characterization, physical stability and in vivo performance.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;38(3):270-8.
2009: Joachim Brouwers; Marcus E Brewster; Patrick Augustijns
Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability?
Journal of pharmaceutical sciences 2009;98(8):2549-72.
2009: Michiel Van Speybroeck; Valéry Barillaro; Thao Do Thi; Randy Mellaerts; Johan Martens; Jan Van Humbeeck; Jan Vermant; Pieter Annaert; Guy Van den Mooter; Patrick Augustijns
Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs.
Journal of pharmaceutical sciences 2009;98(8):2648-58.
2009: Roel Mallants; Valerie Vlaeminck; Mark Jorissen; Patrick Augustijns
An improved primary human nasal cell culture for the simultaneous determination of transepithelial transport and ciliary beat frequency.
The Journal of pharmacy and pharmacology 2009;61(7):883-90.
2009: Raf Mols; Joachim Brouwers; Alfred H Schinkel; Pieter Annaert; Patrick Augustijns
Intestinal perfusion with mesenteric blood sampling in wild-type and knockout mice: evaluation of a novel tool in biopharmaceutical drug profiling.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(6):1334-7.
2009: Sarah Clarysse; Dimitrios Psachoulias; Joachim Brouwers; Jan Tack; Pieter Annaert; Guus S Duchateau; Christos Reppas; Patrick Augustijns
Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs.
Pharmaceutical research 2009;26(6):1456-66.
2009: Bernard Van Eerdenbrugh; Jan Vermant; Johan A Martens; Ludo Froyen; Jan Van Humbeeck; Patrick Augustijns; Guy Van den Mooter
A screening study of surface stabilization during the production of drug nanocrystals.
Journal of pharmaceutical sciences 2009;98(6):2091-103.
2009: S Clarysse; Jan Tack; Frank Lammert; Guus S Duchateau; C Reppas; Patrick Augustijns
Postprandial evolution in composition and characteristics of human duodenal fluids in different nutritional states.
Journal of pharmaceutical sciences 2009;98(3):1177-92.
2009: Alexandre Zatkovskis Carvalho; Tine Dupas; Joachim Brouwers; Jos Hoogmartens; Patrick Augustijns; Ann Van Schepdael
Capillary zone electrophoresis method development for the analysis of Hippeastrum hybrid agglutinin samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(5-6):563-7.
2009: Bart Roucourt; Nikki Minnebo; Patrick Augustijns; Kirsten Hertveldt; Guido Volckaert; Rob Lavigne
Biochemical characterization of malate synthase G of P. aeruginosa.
BMC biochemistry 2009;10():20.
2009: Bernard Van Eerdenbrugh; Bernard Stuyven; Ludo Froyen; Jan Van Humbeeck; Johan A Martens; Patrick Augustijns; Guy Van den Mooter
Downscaling drug nanosuspension production: processing aspects and physicochemical characterization.
AAPS PharmSciTech 2009;10(1):44-53.
2008: Rose Hayeshi; Constanze Hilgendorf; Per Artursson; Patrick Augustijns; Birger Brodin; Pascale Dehertogh; Karen Fisher; Lina Fossati; Egbert Hovenkamp; Timo Korjamo; Chantal Masungi; Nathalie Maubon; Raf Mols; Anette Müllertz; Jukka Mönkkönen; Caitriona O'Driscoll; H M Oppers-Tiemissen; Eva G E Ragnarsson; Martijn Rooseboom; Anna-Lena Ungell
Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;35(5):383-96.
2008: Bernard Van Eerdenbrugh; Guy Van den Mooter; Patrick Augustijns
Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products.
International journal of pharmaceutics 2008;364(1):64-75.
2008: Bernard Van Eerdenbrugh; Sofie Vercruysse; Johan A Martens; Jan Vermant; Ludo Froyen; Jan Van Humbeeck; Guy Van den Mooter; Patrick Augustijns
Microcrystalline cellulose, a useful alternative for sucrose as a matrix former during freeze-drying of drug nanosuspensions - a case study with itraconazole.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(2):590-6.
2008: Bernard Van Eerdenbrugh; Ludo Froyen; Jan Van Humbeeck; Johan A Martens; Patrick Augustijns; Guy Van den Mooter
Drying of crystalline drug nanosuspensions-the importance of surface hydrophobicity on dissolution behavior upon redispersion.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;35(1-2):127-35.
2008: Valéry Barillaro; Paolo P Pescarmona; Michiel Van Speybroeck; Thao Do Thi; Jan Van Humbeeck; Jan Vermant; Patrick Augustijns; Johan A Martens; Guy Van den Mooter
High-throughput study of phenytoin solid dispersions: formulation using an automated solvent casting method, dissolution testing, and scaling-up.
Journal of combinatorial chemistry 2008;10(5):637-43.
2008: Joachim Brouwers; Kurt Vermeire; Dominique Schols; Patrick Augustijns
Development and in vitro evaluation of chloroquine gels as microbicides against HIV-1 infection.
Virology 2008;378(2):306-10.
2008: Randy Mellaerts; Jasper A G Jammaer; Michiel Van Speybroeck; Hong Chen; Jan Van Humbeeck; Patrick Augustijns; Guy Van den Mooter; Johan A Martens
Physical state of poorly water soluble therapeutic molecules loaded into SBA-15 ordered mesoporous silica carriers: a case study with itraconazole and ibuprofen.
Langmuir : the ACS journal of surfaces and colloids 2008;24(16):8651-9.
2008: Anne-Laure Villard; Gaëlle Coussot; Isabelle Lefebvre; Patrick Augustijns; Anne-Marie Aubertin; Gilles Gosselin; Suzanne Peyrottes; Christian Périgaud
Phenyl phosphotriester derivatives of AZT: variations upon the SATE moiety.
Bioorganic & medicinal chemistry 2008;16(15):7321-9.
2008: Martin Foltz; Anja Cerstiaens; Ans van Meensel; Raf Mols; Pieter Van der Pijl; Guus S Duchateau; Patrick Augustijns
The angiotensin converting enzyme inhibitory tripeptides Ile-Pro-Pro and Val-Pro-Pro show increasing permeabilities with increasing physiological relevance of absorption models.
Peptides 2008;29(8):1312-20.
2008: Zhi-Wei Ye; Patrick Augustijns; Pieter Annaert
Cellular accumulation of cholyl-glycylamido-fluorescein in sandwich-cultured rat hepatocytes: kinetic characterization, transport mechanisms, and effect of human immunodeficiency virus protease inhibitors.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(7):1315-21.
2008: Randy Mellaerts; Raf Mols; Pieterjan Kayaert; Pieter Annaert; Jan Van Humbeeck; Guy Van den Mooter; Johan A Martens; Patrick Augustijns
Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport.
International journal of pharmaceutics 2008;357(1-2):169-79.
2008: Souzan B Yanni; Pieter Annaert; Patrick Augustijns; Arlene Bridges; Yan Gao; Daniel K Benjamin; Dhiren R Thakker
Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(6):1119-25.
2008: Kurt Vermeire; Joachim Brouwers; Yven Van Herrewege; Roger Le Grand; Guido Vanham; Patrick Augustijns; Thomas W Bell; Dominique Schols
CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor.
Current HIV research 2008;6(3):246-56.
2008: Randy Mellaerts; Raf Mols; Jasper A G Jammaer; Caroline A Aerts; Pieter Annaert; Jan Van Humbeeck; Guy Van den Mooter; Patrick Augustijns; Johan A Martens
Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;69(1):223-30.
2008: Roel Mallants; Mark Jorissen; Patrick Augustijns
Beneficial effect of antibiotics on ciliary beat frequency of human nasal epithelial cells exposed to bacterial toxins.
The Journal of pharmacy and pharmacology 2008;60(4):437-43.
2008: Andreas Neher; Michaela Gstöttner; Michael Thaurer; Patrick Augustijns; Monika Reinelt; Wolfgang Schobersberger
Influence of essential and fatty oils on ciliary beat frequency of human nasal epithelial cells.
American journal of rhinology 2008;22(2):130-4.
2007: Joachim Brouwers; Jan Tack; Patrick Augustijns
Parallel monitoring of plasma and intraluminal drug concentrations in man after oral administration of fosamprenavir in the fasted and fed state.
Pharmaceutical research 2007;24(10):1862-9.
2007: B Van Eerdenbrugh; L Froyen; Johan A Martens; Norbert Blaton; Patrick Augustijns; Marcus E Brewster; Guy Van den Mooter
Characterization of physico-chemical properties and pharmaceutical performance of sucrose co-freeze-dried solid nanoparticulate powders of the anti-HIV agent loviride prepared by media milling.
International journal of pharmaceutics 2007;338(1-2):198-206.
2007: R Mallants; Mark Jorissen; Patrick Augustijns
Effect of preservatives on ciliary beat frequency in human nasal epithelial cell culture: single versus multiple exposure.
International journal of pharmaceutics 2007;338(1-2):64-9.
2007: Joachim Brouwers; Jan Tack; Patrick Augustijns
In vitro behavior of a phosphate ester prodrug of amprenavir in human intestinal fluids and in the Caco-2 system: illustration of intraluminal supersaturation.
International journal of pharmaceutics 2007;336(2):302-9.
2007: Randy Mellaerts; Caroline A Aerts; Jan Van Humbeeck; Patrick Augustijns; Guy Van den Mooter; Johan A Martens
Enhanced release of itraconazole from ordered mesoporous SBA-15 silica materials.
Chemical communications (Cambridge, England) 2007;(13):1375-7.
2007: Jurgen Mensch; Mark Noppe; Jef Adriaensen; Anouche Melis; Claire Mackie; Patrick Augustijns; Marcus E Brewster
Novel generic UPLC/MS/MS method for high throughput analysis applied to permeability assessment in early Drug Discovery.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;847(2):182-7.
2006: Mariangeles Perez de la Cruz Moreno; Marianne Oth; Sven Deferme; Frank Lammert; Jan Tack; Jennifer Dressman; Patrick Augustijns
Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum.
The Journal of pharmacy and pharmacology 2006;58(8):1079-89.
2006: Joachim Brouwers; Jan Tack; Frank Lammert; Patrick Augustijns
Intraluminal drug and formulation behavior and integration in in vitro permeability estimation: a case study with amprenavir.
Journal of pharmaceutical sciences 2006;95(2):372-83.
2005: Raf Mols; Sven Deferme; Patrick Augustijns
Sulfasalazine transport in in-vitro, ex-vivo and in-vivo absorption models: contribution of efflux carriers and their modulation by co-administration of synthetic nature-identical fruit extracts.
The Journal of pharmacy and pharmacology 2005;57(12):1565-73.
2005: Els Mehuys; Jean Paul Remon; A Korst; Luc M Van Bortel; Raf Mols; Patrick Augustijns; C Porter; Chris Vervaet
Human bioavailability of propranolol from a matrix-in-cylinder system with a HPMC-Gelucire core.
Journal of controlled release : official journal of the Controlled Release Society 2005;107(3):523-36.
2005: R Mallants; K Van Oosterwyck; L Van Vaeck; Raf Mols; E De Clercq; Patrick Augustijns
Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(10-11):1055-66.
2005: Vanessa Vermeirssen; Patrick Augustijns; Nicole Morel; John Van Camp; Anne Opsomer; Willy Verstraete
In vitro intestinal transport and antihypertensive activity of ACE inhibitory pea and whey digests.
International journal of food sciences and nutrition 2005;56(6):415-30.
2005: Joachim Brouwers; Françoise M Ingels; Jan Tack; Patrick Augustijns
Determination of intraluminal theophylline concentrations after oral intake of an immediate- and a slow-release dosage form.
The Journal of pharmacy and pharmacology 2005;57(8):987-96.
2005: Stefan S De Buck; Patrick Augustijns; Claude P Muller
Specific antibody modulates absorptive transport and metabolic activation of benzo[a]pyrene across Caco-2 monolayers.
The Journal of pharmacology and experimental therapeutics 2005;313(2):640-6.
2005: Svetlana Dimova; Frederik Maes; Marcus E Brewster; Mark Jorissen; Mark Noppe; Patrick Augustijns
High-speed digital imaging method for ciliary beat frequency measurement.
The Journal of pharmacy and pharmacology 2005;57(4):521-6.
2005: Svetlana Dimova; V Vlaeminck; Marcus E Brewster; Mark Noppe; Mark Jorissen; Patrick Augustijns
Stable ciliary activity in human nasal epithelial cells grown in a perfusion system.
International journal of pharmaceutics 2005;292(1-2):157-68.
2005: Svetlana Dimova; Marcus E Brewster; Mark Noppe; Mark Jorissen; Patrick Augustijns
The use of human nasal in vitro cell systems during drug discovery and development.
Toxicology in vitro : an international journal published in association with BIBRA 2005;19(1):107-22.
2004: Chantal Masungi; Caroline Borremans; Bart Willems; Jurgen Mensch; Alex Van Dijck; Patrick Augustijns; Marcus E Brewster; Mark Noppe
Usefulness of a novel Caco-2 cell perfusion system. I. In vitro prediction of the absorption potential of passively diffused compounds.
Journal of pharmaceutical sciences 2004;93(10):2507-21.
2004: Pham Thi Thanh Ha; Ann Van Schepdael; Laurence Van Vaeck; Patrick Augustijns; Jos Hoogmartens
Chiral capillary electrophoretic method for quantification of apomorphine.
Journal of chromatography. A 2004;1049(1-2):195-203.
2004: Françoise M Ingels; B Beck; Marianne Oth; Patrick Augustijns
Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers.
International journal of pharmaceutics 2004;274(1-2):221-32.
2004: Patrick Augustijns; Raf Mols
HPLC with programmed wavelength fluorescence detection for the simultaneous determination of marker compounds of integrity and P-gp functionality in the Caco-2 intestinal absorption model.
Journal of pharmaceutical and biomedical analysis 2004;34(5):971-8.
2003: Jan M C Geuns; Patrick Augustijns; Raf Mols; Johan Buyse; Bert Driessen
Metabolism of stevioside in pigs and intestinal absorption characteristics of stevioside, rebaudioside A and steviol.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(11):1599-607.
2003: Svetlana Dimova; R Mugabowindekwe; Tom Willems; Marcus E Brewster; Mark Noppe; A Ludwig; Mark Jorissen; Patrick Augustijns
Safety-assessment of 3-methoxyquercetin as an antirhinoviral compound for nasal application: effect on ciliary beat frequency.
International journal of pharmaceutics 2003;263(1-2):95-103.
2003: Françoise M Ingels; Patrick Augustijns
Biological, pharmaceutical, and analytical considerations with respect to the transport media used in the absorption screening system, Caco-2.
Journal of pharmaceutical sciences 2003;92(8):1545-58.
2003: Sven Deferme; Jan Tack; Frank Lammert; Patrick Augustijns
P-glycoprotein attenuating effect of human intestinal fluid.
Pharmaceutical research 2003;20(6):900-3.
2003: Sven Deferme; Appolinary A R Kamuhabwa; C Nshimo; Peter De Witte; Patrick Augustijns
Screening of Tanzanian plant extracts for their potential inhibitory effect on P-glycoprotein mediated efflux.
Phytotherapy research : PTR 2003;17(5):459-64.
2003: T Van Nijlen; K Brennan; Guy Van den Mooter; Norbert Blaton; Renaat Kinget; Patrick Augustijns
Improvement of the dissolution rate of artemisinin by means of supercritical fluid technology and solid dispersions.
International journal of pharmaceutics 2003;254(2):173-81.
2003: Sven Deferme; Patrick Augustijns
The effect of food components on the absorption of P-gp substrates: a review.
The Journal of pharmacy and pharmacology 2003;55(2):153-62.
2002: Sven Deferme; Raf Mols; Willy Van Driessche; Patrick Augustijns
Apricot extract inhibits the P-gp-mediated efflux of talinolol.
Journal of pharmaceutical sciences 2002;91(12):2539-48.
2002: Françoise M Ingels; Sven Deferme; N Delbar; Marianne Oth; Patrick Augustijns
Implementation of the caco-2 cell culture model as a predictive tool for the oral absorption of drugs. In-house evaluation procedures.
Journal de pharmacie de Belgique 2002;57(6):153-8.
2002: Sven Deferme; Jan Van Gelder; Patrick Augustijns
Inhibitory effect of fruit extracts on P-glycoprotein-related efflux carriers: an in-vitro screening.
The Journal of pharmacy and pharmacology 2002;54(9):1213-9.
2002: Jan Van Gelder; Sven Deferme; Lieve Naesens; Erik De Clercq; Guy Van den Mooter; Renaat Kinget; Patrick Augustijns
Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(8):924-30.
2002: Sven Deferme; Jan Van Gelder; Françoise M Ingels; Guy Van den Mooter; Stefan S De Buck; Jan Balzarini; Lieve Naesens; Erik De Clercq; Renaat Kinget; Patrick Augustijns
Intestinal absorption characteristics of the low solubility thiocarboxanilide UC-781.
International journal of pharmaceutics 2002;234(1-2):113-9.
2002: B Maris; Loes Verheyden; C Samyn; Patrick Augustijns; Renaat Kinget; Guy Van den Mooter
Influence of the composition of in-vitro azo-reducing systems on the degradation kinetics of the model compound amaranth.
The Journal of pharmacy and pharmacology 2002;54(2):197-203.
2002: Françoise M Ingels; Sven Deferme; E Destexhe; Marianne Oth; Guy Van den Mooter; Patrick Augustijns
Simulated intestinal fluid as transport medium in the Caco-2 cell culture model.
International journal of pharmaceutics 2002;232(1-2):183-92.
2002: Vanessa Vermeirssen; John Van Camp; Patrick Augustijns; Willy Verstraete
Angiotensin-I Converting Enzyme (ACE) inhibitory peptides derived from pea and whey protein.
Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen) 2002;67(4):27-30.
2001: Remigius U Agu; Mark Jorissen; Tom Willems; Patrick Augustijns; Renaat Kinget; Norbert Verbeke
In-vitro nasal drug delivery studies: comparison of derivatised, fibrillar and polymerised collagen matrix-based human nasal primary culture systems for nasal drug delivery studies.
The Journal of pharmacy and pharmacology 2001;53(11):1447-56.
2001: Steven Verheyen; Patrick Augustijns; Renaat Kinget; Guy Van den Mooter
Determination of partial solubility parameters of five benzodiazepines in individual solvents.
International journal of pharmaceutics 2001;228(1-2):199-207.
2001: Festo Damian; Norbert Blaton; HO Desseyn; K Clou; Patrick Augustijns; Lieve Naesens; Jan Balzarini; Renaat Kinget; Guy Van den Mooter
Solid state properties of pure UC-781 and solid dispersions with polyvinylpyrrolidone (PVP K30).
The Journal of pharmacy and pharmacology 2001;53(8):1109-16.
2001: Manijeh Shafiee; Sven Deferme; A L Villard; David Egron; Gilles Gosselin; Jean-Louis Imbach; Thierry Lioux; A Pompon; S Varray; A M Aubertin; Guy Van den Mooter; Renaat Kinget; Christian Périgaud; Patrick Augustijns
New bis(SATE) prodrug of AZT 5'-monophosphate: in vitro anti-HIV activity, stability, and potential oral absorption.
Journal of pharmaceutical sciences 2001;90(4):448-63.
2001: Karel Six; Geert Verreck; Jef Peeters; Patrick Augustijns; Renaat Kinget; Guy Van den Mooter
Characterization of glassy itraconazole: a comparative study of its molecular mobility below T(g) with that of structural analogues using MTDSC.
International journal of pharmaceutics 2001;213(1-2):163-73.
2001: B Maris; Loes Verheyden; Kristien Van Reeth; C Samyn; Patrick Augustijns; Renaat Kinget; Guy Van den Mooter
Synthesis and characterisation of inulin-azo hydrogels designed for colon targeting.
International journal of pharmaceutics 2001;213(1-2):143-52.
2001: Guy Van den Mooter; M Wuyts; Norbert Blaton; Roger Busson; P Grobet; Patrick Augustijns; Renaat Kinget
Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrrolidone K25.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;12(3):261-9.
2000: Jan Van Gelder; Sven Deferme; Pieter Annaert; Lieve Naesens; Erik De Clercq; Guy Van den Mooter; Renaat Kinget; Patrick Augustijns
Increased absorption of the antiviral ester prodrug tenofovir disoproxil in rat ileum by inhibiting its intestinal metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(12):1394-6.
2000: Jan Van Gelder; Manijeh Shafiee; Erik De Clercq; F Penninckx; Guy Van den Mooter; Renaat Kinget; Patrick Augustijns
Species-dependent and site-specific intestinal metabolism of ester prodrugs.
International journal of pharmaceutics 2000;205(1-2):93-100.
2000: Michael I Ugwoke; Remigius U Agu; Mark Jorissen; Patrick Augustijns; R Sciot; Norbert Verbeke; Renaat Kinget
Toxicological investigations of the effects carboxymethylcellulose on ciliary beat frequency of human nasal epithelial cells in primary suspension culture and in vivo on rabbit nasal mucosa.
International journal of pharmaceutics 2000;205(1-2):43-51.
2000: Michael I Ugwoke; Remigius U Agu; Hubert P Vanbilloen; J Baetens; Patrick Augustijns; Norbert Verbeke; Luc Mortelmans; Alfons Verbruggen; Renaat Kinget; Guy Bormans
Scintigraphic evaluation in rabbits of nasal drug delivery systems based on carbopol 971p((R)) and carboxymethylcellulose.
Journal of controlled release : official journal of the Controlled Release Society 2000;68(2):207-14.
2000: Pieter Annaert; J J Tukker; Jan Van Gelder; Lieve Naesens; Erik De Clercq; Guy Van den Mooter; Renaat Kinget; Patrick Augustijns
In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil.
Journal of pharmaceutical sciences 2000;89(8):1054-62.
2000: Michael I Ugwoke; Remigius U Agu; Mark Jorissen; Patrick Augustijns; R Sciot; Norbert Verbeke; Renaat Kinget
Nasal toxicological investigations of Carbopol 971P formulation of apomorphine: effects on ciliary beat frequency of human nasal primary cell culture and in vivo on rabbit nasal mucosa.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;9(4):387-96.
2000: R Uchenna Agu; Mark Jorissen; Tom Willems; Guy Van den Mooter; Renaat Kinget; Norbert Verbeke; Patrick Augustijns
Safety assessment of selected cyclodextrins - effect on ciliary activity using a human cell suspension culture model exhibiting in vitro ciliogenesis.
International journal of pharmaceutics 2000;193(2):219-26.
2000: Festo Damian; Norbert Blaton; Lieve Naesens; Jan Balzarini; Renaat Kinget; Patrick Augustijns; Guy Van den Mooter
Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;10(4):311-22.
1999: Appolinary R Kamuhabwa; Patrick Augustijns; Peter A M De Witte
In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model.
International journal of pharmaceutics 1999;188(1):81-6.
1999: Jan Van Gelder; Myriam Witvrouw; Christophe Pannecouque; Geoffrey Henson; Gary J Bridger; Lieve Naesens; Erik De Clercq; Pieter Annaert; Manijeh Shafiee; Guy Van den Mooter; Renaat Kinget; Patrick Augustijns
Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.
International journal of pharmaceutics 1999;186(2):127-36.
1999: Remigius U Agu; Mark Jorissen; Tom Willems; Guy Van den Mooter; Renaat Kinget; Patrick Augustijns
Effects of pharmaceutical compounds on ciliary beating in human nasal epithelial cells: a comparative study of cell culture models.
Pharmaceutical research 1999;16(9):1380-5.
1999: Jan Van Gelder; Pieter Annaert; Lieve Naesens; Erik De Clercq; Guy Van den Mooter; Renaat Kinget; Patrick Augustijns
Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study.
Pharmaceutical research 1999;16(7):1035-40.
1999: Lies Vervoort; I Vinckier; Paula Moldenaers; Guy Van den Mooter; Patrick Augustijns; Renaat Kinget
Inulin hydrogels as carriers for colonic drug targeting. Rheological characterization of the hydrogel formation and the hydrogel network.
Journal of pharmaceutical sciences 1999;88(2):209-14.
1999: Patrick Augustijns; L Peeters; K Croes; R K Verbeeck
Stereoselective de-ethylation of chloroquine in rat liver microsomes.
European journal of drug metabolism and pharmacokinetics 1999;24(1):105-8.
1998: Guy Van den Mooter; G Stas; Festo Damian; Lieve Naesens; Jan Balzarini; Renaat Kinget; Patrick Augustijns
Stability of UC-781, in intestinal mucosal homogenates of the rat, rabbit, and pig.
Pharmaceutical research 1998;15(11):1799-802.
1998: Pieter Annaert; Jan Van Gelder; Lieve Naesens; Erik De Clercq; Guy Van den Mooter; Renaat Kinget; Patrick Augustijns
Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers.
Pharmaceutical research 1998;15(8):1168-73.
1998: Lieve Naesens; Norbert Bischofberger; Patrick Augustijns; Pieter Annaert; Guy Van den Mooter; MN Arimilli; Choung U Kim; Erik De Clercq
Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice.
Antimicrobial agents and chemotherapy 1998;42(7):1568-73.
1998: Pieter Annaert; Gilles Gosselin; A Pompon; S Benzaria; G Valette; Jean-Louis Imbach; Lieve Naesens; Sigrid Hatse; Erik De Clercq; Guy Van den Mooter; Renaat Kinget; Patrick Augustijns
Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
Pharmaceutical research 1998;15(2):239-45.
1997: Lies Vervoort; Guy Van den Mooter; Patrick Augustijns; Roger Busson; Suzanne Toppet; Renaat Kinget
Inulin hydrogels as carriers for colonic drug targeting: I. Synthesis and characterization of methacrylated inulin and hydrogel formation.
Pharmaceutical research 1997;14(12):1730-7.
1997: Guy Van den Mooter; B Maris; C Samyn; Patrick Augustijns; Renaat Kinget
Use of azo polymers for colon-specific drug delivery.
Journal of pharmaceutical sciences 1997;86(12):1321-7.
1997: Pieter Annaert; Renaat Kinget; Lieve Naesens; Erik De Clercq; Patrick Augustijns
Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
Pharmaceutical research 1997;14(4):492-6.
1996: A A Raoof; Patrick Augustijns; Roger K Verbeeck
In vivo assessment of intestinal, hepatic, and pulmonary first pass metabolism of propofol in the rat.
Pharmaceutical research 1996;13(6):891-5.
1996: Patrick Augustijns; A D'Hulst; J Van Daele; Renaat Kinget
Transport of artemisinin and sodium artesunate in Caco-2 intestinal epithelial cells.
Journal of pharmaceutical sciences 1996;85(6):577-9.
1996: Patrick Augustijns
Uptake and transport characteristics of chloroquine in an in-vitro cell culture system of the intestinal mucosa, Caco-2.
The Journal of pharmacy and pharmacology 1996;48(3):277-80.
1994: E Sam; Patrick Augustijns; Norbert Verbeke
Stability of apomorphine in plasma and its determination by high-performance liquid chromatography with electrochemical detection.
Journal of chromatography. B, Biomedical applications 1994;658(2):311-7.
1993: K Croes; Patrick Augustijns; Marc Sabbe; K Desmet; Norbert Verbeke
Diminished sedation during diazepam treatment for chloroquine intoxication.
Pharmacy world & science : PWS 1993;15(2):83-5.
1993: Patrick Augustijns; Norbert Verbeke
Stereoselective pharmacokinetic properties of chloroquine and de-ethyl-chloroquine in humans.
Clinical pharmacokinetics 1993;24(3):259-69.
1992: Patrick Augustijns; Norbert Verbeke
Stereoselectivity in the disposition of chloroquine and desethylchloroquine in rabbits.
Arzneimittel-Forschung 1992;42(6):825-8.
1992: Patrick Augustijns; P Geusens; Norbert Verbeke
Chloroquine levels in blood during chronic treatment of patients with rheumatoid arthritis.
European journal of clinical pharmacology 1992;42(4):429-33.
1991: Patrick Augustijns; Henk Jongsma; Norbert Verbeke
Transplacental distribution of chloroquine in sheep.
Developmental pharmacology and therapeutics 1991;17(3-4):191-9.