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Rolf Brekken

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Xinyu Li; Hongmei Zhang; Qinbo Zhou; Chastain Anderson; Rolf Brekken; Michael Dellinger; Jakub Hanus; Shusheng Wang
Inhibition of multiple pathogenic pathways by histone deacetylase inhibitor SAHA in a corneal alkali-burn injury model.
Douglas D Benson; Rolf Brekken; Marie S Burdine; Christopher C Silliman; Adam W Beck; Carlton C Barnett
Accumulation of pro-cancer cytokines in the plasma fraction of stored packed red cells.
Shanna A Arnold; Amy D Bradshaw; Juliet G Carbon; Chi-Lun Chang; Lee B Rivera; Jason E Toombs; Rolf Brekken
Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFβ activation.

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2013: Xinyu Li; Hongmei Zhang; Qinbo Zhou; Chastain Anderson; Rolf Brekken; Michael Dellinger; Jakub Hanus; Shusheng Wang
Inhibition of multiple pathogenic pathways by histone deacetylase inhibitor SAHA in a corneal alkali-burn injury model.
Molecular pharmaceutics 2013;10(1):307-18.
2012: Douglas D Benson; Rolf Brekken; Marie S Burdine; Christopher C Silliman; Adam W Beck; Carlton C Barnett
Accumulation of pro-cancer cytokines in the plasma fraction of stored packed red cells.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2012;16(3):460-8.
2012: Shanna A Arnold; Amy D Bradshaw; Juliet G Carbon; Chi-Lun Chang; Lee B Rivera; Jason E Toombs; Rolf Brekken
Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFβ activation.
PloS one 2012;7(2):e31384.
2011: Yu-An Zhang; Rolf Brekken; Eugene Frenkel; Boning Gao; Luc Girard; Jer-Tsong Hsieh; Collins A Karikari; Anirban Maitra; John D Minna; CRAIG PEACOCK; Charles Rudin; Victor Stastny; Ignacio Wistuba; Adi F Gazdar
Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts.
Cancer biology & therapy 2011;12(7):617-28.
2011: Yi-Hung Ou; Michael Torres; Rosalyn Ram; Etienne FORMSTECHER; Christina Roland; Tzuling Cheng; Rolf Brekken; Ryan Wurz; Andrew Tasker; Tony Polverino; Seng-Lai Tan; Michael A White
TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.
Molecular cell 2011;41(4):458-70.
2011: Long Shan Li; Erik A Bey; Ying Dong; Jieru Meng; Biswanath Patra; Jingsheng Yan; Xian-Jin Xie; Rolf Brekken; Carlton C Barnett; William G Bornmann; Jinming Gao; David A Boothman
Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(2):275-85.
2011: Niranjan Awasthi; Amanda Kirane; Margaret A Schwarz; Jason E Toombs; Rolf Brekken; Roderich E Schwarz
Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer.
BMC cancer 2011;11():15.
2010: Aline Lisie Ramos; radbod darabi; Nasrin Akbarloo; Luciene Borges; Jacquelyn Catanese; Sean P Dineen; Rolf Brekken; Rita C R Perlingeiro
Clonal analysis reveals a common progenitor for endothelial, myeloid, and lymphoid precursors in umbilical cord blood.
Circulation research 2010;107(12):1460-9.
2010: Luis M De León-Rodríguez; Angelo Lubag; D Gomika Udugamasooriya; Bettina Proneth; Rolf Brekken; Xiankai Sun; Thomas Kodadek; A Dean Sherry
MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting.
Journal of the American Chemical Society 2010;132(37):12829-31.
2010: Marie K Schluterman; Shelby L Chapman; Grzegorz Korpanty; Kiyoshi Ozumi; Tohru Fukai; Hiromi Yanagisawa; Rolf Brekken
Loss of fibulin-5 binding to beta1 integrins inhibits tumor growth by increasing the level of ROS.
Disease models & mechanisms 2010;3(5-6):333-42.
2010: Sean P Dineen; Christina L Roland; Rachel Greer; Juliet G Carbon; Jason E Toombs; Puja Gupta; Nabeel Bardeesy; Haizhou Sun; Noelle Williams; John D Minna; Rolf Brekken
Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer.
Cancer research 2010;70(7):2852-61.
2010: Christina L Roland; Sean P Dineen; Jason E Toombs; Juliet G Carbon; C Wayne Smith; Rolf Brekken; Carlton C Barnett
Tumor-derived intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic xenografts.
Experimental biology and medicine (Maywood, N.J.) 2010;235(2):263-70.
2010: Laura A Sullivan; Juliet G Carbon; Christina L Roland; Jason E Toombs; Mari Nyquist-Andersen; Anita Kavlie; Kyle Schlunegger; James A Richardson; Rolf Brekken
r84, a novel therapeutic antibody against mouse and human VEGF with potent anti-tumor activity and limited toxicity induction.
PloS one 2010;5(8):e12031.
2010: Kristi D Lynn; D Gomika Udugamasooriya; Christina L Roland; Diego H Castrillon; Thomas J Kodadek; Rolf Brekken
GU81, a VEGFR2 antagonist peptoid, enhances the anti-tumor activity of doxorubicin in the murine MMTV-PyMT transgenic model of breast cancer.
BMC cancer 2010;10():397.
2010: Shanna A Arnold; Lee B Rivera; Andrew F Miller; Juliet G Carbon; Sean P Dineen; Yang Xie; Diego H Castrillon; E Helene Sage; Pauli Puolakkainen; Amy D Bradshaw; Rolf Brekken
Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma.
Disease models & mechanisms 2010;3(1-2):57-72.
2009: Shanna A Arnold; Rolf Brekken
SPARC: a matricellular regulator of tumorigenesis.
Journal of cell communication and signaling 2009;3(3-4):255-73.
2009: Hiromi Yanagisawa; Marie K Schluterman; Rolf Brekken
Fibulin-5, an integrin-binding matricellular protein: its function in development and disease.
Journal of cell communication and signaling 2009;3(3-4):337-47.
2009: Romulo J C Albuquerque; Takahiko Hayashi; Won Gil Cho; Mark E Kleinman; Sami Dridi; Atsunobu Takeda; Judit Baffi; Kiyoshi Yamada; Hiroki Kaneko; Martha G Green; Joe Chappell; Jörg Wilting; Herbert A Weich; Satoru Yamagami; Shiro Amano; Nobuhisa Mizuki; Jonathan S Alexander; Martha L Peterson; Rolf Brekken; Masanori Hirashima; Seema Capoor; Tomohiko Usui; Balamurali K Ambati; Jayakrishna Ambati
Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.
Nature medicine 2009;15(9):1023-30.
2009: Nils Halberg; Tayeba Khan; Maria E Trujillo; Ingrid Wernstedt-Asterholm; Alan D Attie; Shariq Sherwani; Zhao V Wang; Shira Landskroner-Eiger; Sean Dineen; Ulysses J Magalang; Rolf Brekken; Philipp E Scherer
Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue.
Molecular and cellular biology 2009;29(16):4467-83.
2009: Christina L Roland; Sean P Dineen; Kristi D Lynn; Laura A Sullivan; Michael T Dellinger; Leila Sadegh; James P Sullivan; David S Shames; Rolf Brekken
Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts.
Molecular cancer therapeutics 2009;8(7):1761-71.
2009: Sean P Dineen; Christina L Roland; Jason E Toombs; Marguerite Kelher; Christopher C Silliman; Rolf Brekken; Carlton C Barnett
The acellular fraction of stored platelets promotes tumor cell invasion.
The Journal of surgical research 2009;153(1):132-7.
2009: A A Arguello; S J Fischer; Josh Schonborn; R W Markus; Rolf Brekken; Amelia J Eisch
Effect of chronic morphine on the dentate gyrus neurogenic microenvironment.
Neuroscience 2009;159(3):1003-10.
2009: Shawna L Bull Phelps; Juliet Carbon; Andrew Miller; Emely Castro-Rivera; Shanna Arnold; Rolf Brekken; Jayanthi S Lea
Secreted protein acidic and rich in cysteine as a regulator of murine ovarian cancer growth and chemosensitivity.
American journal of obstetrics and gynecology 2009;200(2):180.e1-7.
2009: Christina L Roland; Kristi D Lynn; Jason E Toombs; Sean P Dineen; D Gomika Udugamasooriya; Rolf Brekken
Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer.
PloS one 2009;4(11):e7669.
2009: Junichi Soh; Naoki Okumura; William W Lockwood; Hiromasa Yamamoto; Hisayuki Shigematsu; Wei Zhang; Raj Chari; David S Shames; Ximing Tang; Calum MacAulay; Marileila Varella-Garcia; Tõnu Vooder; Ignacio I Wistuba; Stephen Lam; Rolf Brekken; Shinichi Toyooka; John D Minna; Wan L Lam; Adi F Gazdar
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.
PloS one 2009;4(10):e7464.
2008: D Gomika Udugamasooriya; Geoff Dunham; Caroline Ritchie; Rolf Brekken; Thomas Kodadek
The pharmacophore of a peptoid VEGF receptor 2 antagonist includes both side chain and main chain residues.
Bioorganic & medicinal chemistry letters 2008;18(22):5892-4.
2008: Sabina Sangaletti; Emma Di Carlo; Silvia Gariboldi; Silvia Miotti; Barbara Cappetti; Mariella Parenza; Cristiano Rumio; Rolf Brekken; Claudia Chiodoni; Mario P Colombo
Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis.
Cancer research 2008;68(21):9050-9.
2008: Emely Castro-Rivera; Sophia Ran; Rolf Brekken; John D Minna
Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells.
Cancer research 2008;68(20):8295-303.
2008: Shanna Arnold; Emilia Mira; Sabeeha Muneer; Grzegorz Korpanty; Adam W Beck; Shane E Holloway; Santos Mañes; Rolf Brekken
Forced expression of MMP9 rescues the loss of angiogenesis and abrogates metastasis of pancreatic tumors triggered by the absence of host SPARC.
Experimental biology and medicine (Maywood, N.J.) 2008;233(7):860-73.
2008: D Gomika Udugamasooriya; Caroline Ritchie; Rolf Brekken; Thomas Kodadek
A peptoid antagonist of VEGF receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site.
Bioorganic & medicinal chemistry 2008;16(12):6338-43.
2008: Sean P Dineen; Kristi D Lynn; Shane E Holloway; Andrew F Miller; James P Sullivan; David Shames; Adam W Beck; Carlton C Barnett; Jason Fleming; Rolf Brekken
Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice.
Cancer research 2008;68(11):4340-6.
2008: D Gomika Udugamasooriya; Sean P Dineen; Rolf Brekken; Thomas Kodadek
A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity.
Journal of the American Chemical Society 2008;130(17):5744-52.
2008: Sean P Dineen; Laura A Sullivan; Adam W Beck; Andrew F Miller; Juliet G Carbon; Roni Mamluk; Henry Wong; Rolf Brekken
The Adnectin CT-322 is a novel VEGF receptor 2 inhibitor that decreases tumor burden in an orthotopic mouse model of pancreatic cancer.
BMC cancer 2008;8():352.
2007: Brandt Whitehurst; Michael J Flister; Juhi Bagaitkar; Lisa Volk; Christopher M Bivens; Brent Pickett; Emely Castro-Rivera; Rolf Brekken; Robert D Gerard; Sophia Ran
Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model.
International journal of cancer. Journal international du cancer 2007;121(10):2181-91.
2007: Yayun Liang; Cynthia Besch-Williford; Rolf Brekken; Salman M Hyder
Progestin-dependent progression of human breast tumor xenografts: a novel model for evaluating antitumor therapeutics.
Cancer research 2007;67(20):9929-36.
2007: Louis Chesler; David D Goldenberg; Isha T Seales; Ronit Satchi-Fainaro; Matt Grimmer; Rodney Collins; Chris Struett; Kim N Nguyen; Grace Kim; Tarik Tihan; Yun Bao; Rolf Brekken; Gabriele Bergers; Judah Folkman; William A Weiss
Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma.
Cancer research 2007;67(19):9435-42.
2007: Chung-Hyun Cho; Young Jun Koh; Jinah Han; Hoon-Ki Sung; Hyuek Jong Lee; Tohru Morisada; Reto Schwendener; Rolf Brekken; Guson Kang; Yuichi Oike; Tae-Saeng Choi; Toshio Suda; Ook Joon Yoo; Gou Young Koh
Angiogenic role of LYVE-1-positive macrophages in adipose tissue.
Circulation research 2007;100(4):e47-57.
2007: May J Reed; Nathan Karres; Daniel Eyman; Abigail Cruz; Rolf Brekken; Stephen R Plymate
The effects of aging on tumor growth and angiogenesis are tumor-cell dependent.
International journal of cancer. Journal international du cancer 2007;120(4):753-60.
2007: Grzegorz Korpanty; Juliet G Carbon; Paul A Grayburn; Jason Fleming; Rolf Brekken
Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(1):323-30.
2006: Yayun Liang; Rolf Brekken; Salman M Hyder
Vascular endothelial growth factor induces proliferation of breast cancer cells and inhibits the anti-proliferative activity of anti-hormones.
Endocrine-related cancer 2006;13(3):905-19.
2006: Justin G Santarelli; Vikram Udani; Yun C Yung; Samuel Cheshier; Amy J Wagers; Rolf Brekken; Irving L Weissman; victor Tse
Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain.
Neurosurgery 2006;59(2):374-82; discussion 374-82.
2006: Shane E Holloway; Adam W Beck; Latha Shivakumar; Jessica Shih; Jason Fleming; Rolf Brekken
Selective blockade of vascular endothelial growth factor receptor 2 with an antibody against tumor-derived vascular endothelial growth factor controls the growth of human pancreatic adenocarcinoma xenografts.
Annals of surgical oncology 2006;13(8):1145-55.
2006: Adam W Beck; Troy A Luster; Andrew F Miller; Shane E Holloway; Chris R Conner; Carlton C Barnett; Philip E Thorpe; Jason Fleming; Rolf Brekken
Combination of a monoclonal anti-phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice.
International journal of cancer. Journal international du cancer 2006;118(10):2639-43.
2006: Bernd Hohenstein; Birgit Hausknecht; K Boehmer; Regine Riess; Rolf Brekken; Christian Hugo
Local VEGF activity but not VEGF expression is tightly regulated during diabetic nephropathy in man.
Kidney international 2006;69(9):1654-61.
2006: Miho Nozaki; Eiji Sakurai; Brian J Raisler; Judit Baffi; Jassir Witta; Yuichiro Ogura; Rolf Brekken; E Helene Sage; Balamurali K Ambati; Jayakrishna Ambati
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A.
The Journal of clinical investigation 2006;116(2):422-9.
2005: Grzegorz Korpanty; Paul A Grayburn; Ralph V Shohet; Rolf Brekken
Targeting vascular endothelium with avidin microbubbles.
Ultrasound in medicine & biology 2005;31(9):1279-83.
2005: Jason Fleming; Guo-Liang Shen; Shane E Holloway; Mishel Davis; Rolf Brekken
Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy.
Molecular cancer research : MCR 2005;3(7):413-23.
2005: Pauli Puolakkainen; Amy D Bradshaw; Rolf Brekken; May J Reed; Themis Kyriakides; Sarah E Funk; Michel D Gooden; Robert B Vernon; Thomas N Wight; Paul Bornstein; E Helene Sage
SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(5):571-81.
2005: Shane E Holloway; Adam W Beck; Luc Girard; M Raffat Jaber; Carlton C Barnett; Rolf Brekken; Jason Fleming
Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer.
Journal of the American College of Surgeons 2005;200(3):371-7.
2005: Justin G Santarelli; Vikram Udani; C Y Yung; Samuel Cheshier; Amy J Wagers; Rolf Brekken; Irving L Weissman; victor Tse
Preuss Resident Research Award: bone marrow-derived Flk-1-expressing CD34+ cells contribute to the endothelium of tumor vessels in mouse brain.
Clinical neurosurgery 2005;52():384-8.
2004: Susann Stephan; Kaustubh Datta; Enfeng Wang; Jinping Li; Rolf Brekken; Sareh Parangi; Philip E Thorpe; Debabrata Mukhopadhyay
Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(20):6993-7000.
2004: Rolf Brekken; Millicent M Sullivan; Gail Workman; Amy D Bradshaw; Juliet G Carbon; Anthony W Siadak; Carrie Murri; Paul E Framson; E Helene Sage
Expression and characterization of murine hevin (SC1), a member of the SPARC family of matricellular proteins.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(6):735-48.
2004: Mariya T Sweetwyne; Rolf Brekken; Gail Workman; Amy D Bradshaw; Juliet G Carbon; Anthony W Siadak; Carrie Murri; E Helene Sage
Functional analysis of the matricellular protein SPARC with novel monoclonal antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(6):723-33.
2004: Fabienne Baffert; Gavin Thurston; Michael Rochon-Duck; Tom Le; Rolf Brekken; Donald M McDonald
Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels.
Circulation research 2004;94(7):984-92.
2004: Pauli Puolakkainen; Rolf Brekken; Sabeeha Muneer; E Helene Sage
Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis.
Molecular cancer research : MCR 2004;2(4):215-24.
2004: Aleksandar Francki; Timothy D McClure; Rolf Brekken; Kouros Motamed; Carrie Murri; Tongwen Wang; E Helene Sage
SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells.
Journal of cellular biochemistry 2004;91(5):915-25.
2004: Vik Gongidi; Colleen Ring; Matt Moody; Rolf Brekken; E Helene Sage; Pasko Rakic; Eva Anton
SPARC-like 1 regulates the terminal phase of radial glia-guided migration in the cerebral cortex.
Neuron 2004;41(1):57-69.
2003: Douglas J Rhee; Robert Fariss; Rolf Brekken; E Helene Sage; Paul Russell
The matricellular protein SPARC is expressed in human trabecular meshwork.
Experimental eye research 2003;77(5):601-7.
2003: Jason Fleming; Rolf Brekken
Functional imaging of angiogenesis in an orthotopic model of pancreatic cancer.
Journal of cellular biochemistry 2003;90(3):492-501.
2003: Michael I Koukourakis; Alexandra Giatromanolaki; Rolf Brekken; Efthimios Sivridis; Kevin C Gatter; Adrian L Harris; E Helene Sage
Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients.
Cancer research 2003;63(17):5376-80.
2003: Eckhard Lammert; Guqiang Gu; Margaret McLaughlin; Dennis Brown; Rolf Brekken; Lewis C. Murtaugh; Hans Peter Gerber; Napoleone Ferrara; Douglas A Melton
Role of VEGF-A in vascularization of pancreatic islets.
Current biology : CB 2003;13(12):1070-4.
2003: Rolf Brekken; Pauli Puolakkainen; David C Graves; Gail Workman; Sharon R Lubkin; E Helene Sage
Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM.
The Journal of clinical investigation 2003;111(4):487-95.
2003: Pauli Puolakkainen; Amy D Bradshaw; Themistoklis R Kyriakides; May Reed; Rolf Brekken; Thomas N Wight; Paul Bornstein; Buddy Ratner; E Helene Sage
Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials.
The American journal of pathology 2003;162(2):627-35.
2002: Dana M Brantley; Nikki Cheng; Erin J Thompson; Qing Lin; Rolf Brekken; Philip E Thorpe; Rebecca Cook; Douglas Pat Cerretti; Ambra Pozzi; Dowdy Jackson; Charles Lin; Jin Chen
Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo.
Oncogene 2002;21(46):7011-26.
2002: Rolf Brekken; Chenggang Li; Shant Kumar
Strategies for vascular targeting in tumors.
International journal of cancer. Journal international du cancer 2002;100(2):123-30.
2001: Ping Guo; Li Xu; S Pan; Rolf Brekken; S T Yang; G Brian Whitaker; Motoo Nagane; P E Thorpe; Jan S Rosenbaum; HJ Su Huang; Webster K Cavenee; Shi-Yuan Cheng
Vascular endothelial growth factor isoforms display distinct activities in promoting tumor angiogenesis at different anatomic sites.
Cancer research 2001;61(23):8569-77.
2001: Alexandra Giatromanolaki; Efthimios Sivridis; Rolf Brekken; PE Thorpe; P Anastasiadis; Kevin C Gatter; Adrian L Harris; Michael I Koukourakis
The angiogenic "vascular endothelial growth factor/flk-1(KDR) receptor" pathway in patients with endometrial carcinoma: prognostic and therapeutic implications.
Cancer 2001;92(10):2569-77.
2001: Rolf Brekken; P E Thorpe
Vascular endothelial growth factor and vascular targeting of solid tumors.
Anticancer research 2001;21(6B):4221-9.
2001: Amy D Bradshaw; May J Reed; Juliet G Carbon; E Pinney; Rolf Brekken; E Helene Sage
Increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges in SPARC-null mice.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2001;9(6):522-30.
2001: Rolf Brekken; P E Thorpe
VEGF-VEGF receptor complexes as markers of tumor vascular endothelium.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):173-81.
2001: Alexandra Giatromanolaki; Efthimios Sivridis; N Athanassou; E Zois; PE Thorpe; Rolf Brekken; Kevin C Gatter; Adrian L Harris; I M Koukourakis; Michael I Koukourakis
The angiogenic pathway "vascular endothelial growth factor/flk-1(KDR)-receptor" in rheumatoid arthritis and osteoarthritis.
The Journal of pathology 2001;194(1):101-8.
2001: Rolf Brekken; E H Sage
SPARC, a matricellular protein: at the crossroads of cell-matrix communication.
Matrix biology : journal of the International Society for Matrix Biology 2001;19(8):816-27.
2000: Rolf Brekken; E H Sage
SPARC, a matricellular protein: at the crossroads of cell-matrix.
Matrix biology : journal of the International Society for Matrix Biology 2000;19(7):569-80.
2000: Gabriele Bergers; Rolf Brekken; G McMahon; T H Vu; T Itoh; K Tamaki; K Tanzawa; P Thorpe; Shigeyoshi Itohara; Zena Werb; Douglas Hanahan
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis.
Nature cell biology 2000;2(10):737-44.
2000: Rolf Brekken; J P Overholser; Victor Stastny; J Waltenberger; John D Minna; Philip E Thorpe
Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice.
Cancer research 2000;60(18):5117-24.
2000: Michael I Koukourakis; Alexandra Giatromanolaki; P E Thorpe; Rolf Brekken; E Sivridis; Stylianos Kakolyris; V Georgoulias; Kevin C Gatter; Adrian L Harris
Vascular endothelial growth factor/KDR activated microvessel density versus CD31 standard microvessel density in non-small cell lung cancer.
Cancer research 2000;60(11):3088-95.
2000: Dian Feng; Janice A Nagy; Rolf Brekken; A Pettersson; Eleanor J Manseau; Kathryn Pyne; R Mulligan; P E Thorpe; Harold F Dvorak; Ann M Dvorak
Ultrastructural localization of the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) receptor-2 (FLK-1, KDR) in normal mouse kidney and in the hyperpermeable vessels induced by VPF/VEGF-expressing tumors and adenoviral vectors.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(4):545-56.
2000: Alexandra Giatromanolaki; Michael I Koukourakis; Efthimios Sivridis; PE Thorpe; Rolf Brekken; S Konstantinos; G Fountzilas; Kevin C Gatter; Adrian L Harris
Tumor specific activation of the VEGF/KDR angiogenic pathway in a subset of locally advanced squamous cell head and neck carcinomas.
Clinical & experimental metastasis 2000;18(4):313-9.
1998: Xianming Huang; Claudia Gottstein; Rolf Brekken; Philip E Thorpe
Expression of soluble VEGF receptor 2 and characterization of its binding by surface plasmon resonance.
Biochemical and biophysical research communications 1998;252(3):643-8.
1998: Rolf Brekken; Xianming Huang; S W King; Philip E Thorpe
Vascular endothelial growth factor as a marker of tumor endothelium.
Cancer research 1998;58(9):1952-9.