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Peter Friedhoff

Research Profile

Chemicals & Drugs

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

Phenomena

Disorders

Base Pair Mismatches

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Publications

TOP 3
Lilia Gabsalilow; Alfred Pingoud; Benno Schierling; Peter Friedhoff; Wolfgang Wende
Site- and strand-specific nicking of DNA by fusion proteins derived from MutH and I-SceI or TALE repeats.
Roger J Heinze; Elena Kubareva; Tatiana S Oretskaya; Svetlana Sekerina; Ines Winkler; Christian Biertümpfel; Peter Friedhoff
Covalently trapping MutS on DNA to study DNA mismatch recognition and signaling.
Michele Cristóvão; Manju M Hingorani; Caroline P Jung; Andreas D Marx; Paul J Rothwell; Claus A M Seidel; Evangelos Sisamakis; Peter Friedhoff
Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA.

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All Publications

2013: Lilia Gabsalilow; Alfred Pingoud; Benno Schierling; Peter Friedhoff; Wolfgang Wende
Site- and strand-specific nicking of DNA by fusion proteins derived from MutH and I-SceI or TALE repeats.
Nucleic acids research 2013;41(7):e83.
2012: Roger J Heinze; Elena Kubareva; Tatiana S Oretskaya; Svetlana Sekerina; Ines Winkler; Christian Biertümpfel; Peter Friedhoff
Covalently trapping MutS on DNA to study DNA mismatch recognition and signaling.
Molecular bioSystems 2012;8(7):1861-4.
2012: Michele Cristóvão; Manju M Hingorani; Caroline P Jung; Andreas D Marx; Paul J Rothwell; Claus A M Seidel; Evangelos Sisamakis; Peter Friedhoff
Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA.
Nucleic acids research 2012;40(12):5448-64.
2012: Marika Midon; Peter Friedhoff; Oleg Gimadutdinow; Gregor Meiss; Alfred Pingoud
Chemical rescue of active site mutants of S. pneumoniae surface endonuclease EndA and other nucleases of the HNH family by imidazole.
Chembiochem : a European journal of chemical biology 2012;13(5):713-21.
2011: Yu Xiao; Peter Friedhoff; Caroline Jung; Joyce H G Lebbink; Andreas D Marx; Ines Winkler; Claire Wyman; Michele Cristovao
Generation of DNA nanocircles containing mismatched bases.
BioTechniques 2011;51(4):259-62, 264-5.
2011: Maria Chiara Monti; Anastassis Perraks; Titia K Sixma; Robert H H van den Heuvel; Herrie H K Winterwerp; Arjan Barendregt; Serge X Cohen; Alexander Fish; Peter Friedhoff; Albert J R Heck; Joyce H G Lebbink
Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS.
Nucleic acids research 2011;39(18):8052-64.
2011: Alexandra Yurievna Ryazanova; Mikhail Borisovich Viryasov; Ines Winkler; Peter Friedhoff; Tatiana S Oretskaya; Elena Kubareva
Crosslinking of (cytosine-5)-DNA methyltransferase SsoII and its complexes with specific DNA duplexes provides an insight into their structures.
Nucleosides, nucleotides & nucleic acids 2011;30(7-8):632-50.
2011: Ines Winkler; Andreas D Marx; Damien Lariviere; Roger J Heinze; Michele Cristovao; Annet Reumer; Ute Curth; Titia K Sixma; Peter Friedhoff
Chemical trapping of the dynamic MutS-MutL complex formed in DNA mismatch repair in Escherichia coli.
The Journal of biological chemistry 2011;286(19):17326-37.
2011: Stefan Hanstein; Xiaozhi Wang; Xiaoqing Qian; Peter Friedhoff; Ammara Fatima; Yuhua Shan; Ke Feng; Sven Schubert
Changes in cytosolic Mg2+ levels can regulate the activity of the plasma membrane H+-ATPase in maize.
The Biochemical journal 2011;435(1):93-101.
2010: A Iu Riazanova; N V Molochkov; L A Abrosimova; A V Alekseevskiĭ; A S Kariagina; A S Protsenko; Peter Friedhoff; T S Oretskaia; Elena Kubareva
[Secondary structure of SsoII-like (cytosine-5)-DNA methyltransferases N-terminal region determined by circular dichroism spectroscopy].
Molekuliarnaia biologiia 2010;44(5):911-21.
2010: Jan Kosinski; Inga Hinrichsen; Janusz Bujnicki; Peter Friedhoff; Guido Plotz
Identification of Lynch syndrome mutations in the MLH1-PMS2 interface that disturb dimerization and mismatch repair.
Human mutation 2010;31(8):975-82.
2010: Monica C Pillon; Jessica J Lorenowicz; Michael Uckelmann; Andrew D Klocko; Ryan R Mitchell; Yu Seon Chung; Paul Modrich; Graham C Walker; Lyle A Simmons; Peter Friedhoff; Alba Guarné
Structure of the endonuclease domain of MutL: unlicensed to cut.
Molecular cell 2010;39(1):145-51.
2010: Mark D Szczelkun; Peter Friedhoff; Ralf Seidel
Maintaining a sense of direction during long-range communication on DNA.
Biochemical Society transactions 2010;38(2):404-9.
2010: Sivakumar Namadurai; Deepti Jain; Dhananjay S Kulkarni; Chaitanya R Tabib; Peter Friedhoff; Desirazu N Rao; Deepak T Nair
The C-terminal domain of the MutL homolog from Neisseria gonorrhoeae forms an inverted homodimer.
PloS one 2010;5(10):e13726.
2009: Vera Pingoud; Wolfgang Wende; Peter Friedhoff; Monika Reuter; Jürgen Alves; Albert Jeltsch; Letif Mones; Monika Fuxreiter; Alfred Pingoud
On the divalent metal ion dependence of DNA cleavage by restriction endonucleases of the EcoRI family.
Journal of molecular biology 2009;393(1):140-60.
2009: Viswanadham Duppatla; Chiranjeevi Bodda; Claus Urbanke; Peter Friedhoff; Desirazu N Rao
The C-terminal domain is sufficient for endonuclease activity of Neisseria gonorrhoeae MutL.
The Biochemical journal 2009;423(2):265-77.
2009: Roger J Heinze; Luis Giron-Monzon; Alexandra Solovyova; Sarah L Elliot; Sven Geisler; Claire G Cupples; Bernard A Connolly; Peter Friedhoff
Physical and functional interactions between Escherichia coli MutL and the Vsr repair endonuclease.
Nucleic acids research 2009;37(13):4453-63.
2008: Jan Kosinski; Guido Plotz; Alba Guarné; Janusz Bujnicki; Peter Friedhoff
The PMS2 subunit of human MutLalpha contains a metal ion binding domain of the iron-dependent repressor protein family.
Journal of molecular biology 2008;382(3):610-27.
2007: Peter Friedhoff; Alfred Pingoud
Engineering site-specific endonucleases.
Methods in molecular biology (Clifton, N.J.) 2007;352():111-23.
2006: Guido Plotz; Christoph Welsch; Luis Giron-Monzon; Peter Friedhoff; Mario Albrecht; Albrecht Piiper; Ricardo M Biondi; Thomas Lengauer; Stefan Zeuzem; Jochen Raedle
Mutations in the MutSalpha interaction interface of MLH1 can abolish DNA mismatch repair.
Nucleic acids research 2006;34(22):6574-86.
2006: Laura Manelyte; Claus Urbanke; Luis Giron-Monzon; Peter Friedhoff
Structural and functional analysis of the MutS C-terminal tetramerization domain.
Nucleic acids research 2006;34(18):5270-9.
2006: Robert Ahrends; Jan Kosinski; Dieter Kirsch; Laura Manelyte; Luis Giron-Monzon; Lars Hummerich; Oliver Schulz; Bernhard Spengler; Peter Friedhoff
Identifying an interaction site between MutH and the C-terminal domain of MutL by crosslinking, affinity purification, chemical coding and mass spectrometry.
Nucleic acids research 2006;34(10):3169-80.
2005: Jan Kosinski; Ina Steindorf; Janusz Bujnicki; Luis Giron-Monzon; Peter Friedhoff
Analysis of the quaternary structure of the MutL C-terminal domain.
Journal of molecular biology 2005;351(4):895-909.
2005: Peter Friedhoff
Mapping protein-protein interactions by bioinformatics and cross-linking.
Analytical and bioanalytical chemistry 2005;381(1):78-80.
2004: Luis Giron-Monzon; Laura Manelyte; Robert Ahrends; Dieter Kirsch; Bernhard Spengler; Peter Friedhoff
Mapping protein-protein interactions between MutL and MutH by cross-linking.
The Journal of biological chemistry 2004;279(47):49338-45.
2003: Björn Tews; Jochen Wilhelm; Daniel Summerer; Michael Strerath; Andreas Marx; Peter Friedhoff; Alfred Pingoud; Meinhard Hahn
Application of the C4'-alkylated deoxyribose primer system (CAPS) in allele-specific real-time PCR for increased selectivity in discrimination of single nucleotide sequence variants.
Biological chemistry 2003;384(10-11):1533-41.
2003: Grischa H Toedt; Ravi Krishnan; Peter Friedhoff
Site-specific protein modification to identify the MutL interface of MutH.
Nucleic acids research 2003;31(3):819-25.
2003: Peter Friedhoff; Evangelos Thomas; Alfred Pingoud
Tyr212: a key residue involved in strand discrimination by the DNA mismatch repair endonuclease MutH.
Journal of molecular biology 2003;325(2):285-97.
2002: Evangelos Thomas; Alfred Pingoud; Peter Friedhoff
An efficient method for the preparation of long heteroduplex DNA as substrate for mismatch repair by the Escherichia coli MutHLS system.
Biological chemistry 2002;383(9):1459-62.
2002: Vera Pingoud; Elena Kubareva; Gudrun Stengel; Peter Friedhoff; Janusz Bujnicki; Claus Urbanke; Anna Sudina; Alfred Pingoud
Evolutionary relationship between different subgroups of restriction endonucleases.
The Journal of biological chemistry 2002;277(16):14306-14.
2002: Peter Friedhoff; Babak Sheybani; Evangelos Thomas; Christian Merz; Alfred Pingoud
Haemophilus influenzae and Vibrio cholerae genes for mutH are able to fully complement a mutH defect in Escherichia coli.
FEMS microbiology letters 2002;208(1):123-8.
2001: Peter Friedhoff; Rudi Lurz; Gerhild Lüder; Alfred Pingoud
Sau3AI, a monomeric type II restriction endonuclease that dimerizes on the DNA and thereby induces DNA loops.
The Journal of biological chemistry 2001;276(26):23581-8.
2001: Gregor Meiss; Oleg Gimadutdinow; Peter Friedhoff; Alfred Pingoud
Microtiter-plate assay and related assays for nonspecific endonucleases.
Methods in molecular biology (Clifton, N.J.) 2001;160():37-48.
2000: Peter Friedhoff; Martin von Bergen; Eva-Maria Mandelkow; Eckhard Mandelkow
Structure of tau protein and assembly into paired helical filaments.
Biochimica et biophysica acta 2000;1502(1):122-32.
2000: Martin von Bergen; Peter Friedhoff; Jacek Biernat; J Heberle; Eva-Maria Mandelkow; Eckhard Mandelkow
Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5129-34.
1999: T K Srivastava; Peter Friedhoff; Alfred Pingoud; Seturam B Katti
Application of oligonucleoside methylphosphonates in the studies on phosphodiester hydrolysis by Serratia endonuclease.
Nucleosides & nucleotides 1999;18(9):1945-60.
1999: Peter Friedhoff; I Franke; Gregor Meiss; Wolfgang Wende; K L Krause; Alfred Pingoud
A similar active site for non-specific and specific endonucleases.
Nature structural biology 1999;6(2):112-3.
1999: Peter Friedhoff; I Franke; K L Krause; Alfred Pingoud
Cleavage experiments with deoxythymidine 3',5'-bis-(p-nitrophenyl phosphate) suggest that the homing endonuclease I-PpoI follows the same mechanism of phosphodiester bond hydrolysis as the non-specific Serratia nuclease.
FEBS letters 1999;443(2):209-14.
1998: Peter Friedhoff; Martin von Bergen; Eva-Maria Mandelkow; Peter Davies; Eckhard Mandelkow
A nucleated assembly mechanism of Alzheimer paired helical filaments.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15712-7.
1998: Peter Friedhoff; A Schneider; Eva-Maria Mandelkow; Eckhard Mandelkow
Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution.
Biochemistry 1998;37(28):10223-30.
1996: T Kampers; Peter Friedhoff; Jacek Biernat; Eva-Maria Mandelkow; Eckhard Mandelkow
RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments.
FEBS letters 1996;399(3):344-9.
1996: B Kolmes; I Franke; Peter Friedhoff; Alfred Pingoud
Analysis of the reaction mechanism of the non-specific endonuclease of Serratia marcescens using an artificial minimal substrate.
FEBS letters 1996;397(2-3):343-6.
1996: Peter Friedhoff; Gregor Meiss; B Kolmes; Uwe Pieper; Oleg Gimadutdinow; Claus Urbanke; Alfred Pingoud
Kinetic analysis of the cleavage of natural and synthetic substrates by the Serratia nuclease.
European journal of biochemistry / FEBS 1996;241(2):572-80.
1996: Peter Friedhoff; S E Matzen; Gregor Meiss; Alfred Pingoud
A quantitative microtiter plate nuclease assay based on ethidium/DNA fluorescence.
Analytical biochemistry 1996;240(2):283-8.
1996: Peter Friedhoff; B Kolmes; Oleg Gimadutdinow; Wolfgang Wende; K L Krause; Alfred Pingoud
Analysis of the mechanism of the Serratia nuclease using site-directed mutagenesis.
Nucleic acids research 1996;24(14):2632-9.
1995: Gregor Meiss; Peter Friedhoff; M Hahn; Oleg Gimadutdinow; Alfred Pingoud
Sequence preferences in cleavage of dsDNA and ssDNA by the extracellular Serratia marcescens endonuclease.
Biochemistry 1995;34(37):11979-88.
1995: M Hahn; V Dörsam; Peter Friedhoff; A Fritz; Alfred Pingoud
Quantitative polymerase chain reaction with enzyme-linked immunosorbent assay detection of selectively digested amplified sample and control DNA.
Analytical biochemistry 1995;229(2):236-48.
1994: Peter Friedhoff; Oleg Gimadutdinow; Alfred Pingoud
Identification of catalytically relevant amino acids of the extracellular Serratia marcescens endonuclease by alignment-guided mutagenesis.
Nucleic acids research 1994;22(16):3280-7.
1994: Peter Friedhoff; Oleg Gimadutdinow; T Rüter; Wolfgang Wende; Claus Urbanke; Hubert Thole; Alfred Pingoud
A procedure for renaturation and purification of the extracellular Serratia marcescens nuclease from genetically engineered Escherichia coli.
Protein expression and purification 1994;5(1):37-43.
1993: Peter Friedhoff; M Hahn; Heiner Wolfes; Alfred Pingoud
Quantitative polymerase chain reaction with oligodeoxynucleotide ligation assay/enzyme-linked immunosorbent assay detection.
Analytical biochemistry 1993;215(1):9-16.