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Emily Cheng

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Chemicals & Drugs

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A Ari Hakimi; Adriana Heguy; Omar Abdel-Wahab; Ying-bei Chen; Emily Cheng; Jonathan Coleman; Mithat Gonen; Han Liu; Robert J Motzer; Victor E Reuter; Paul Russo; Shugaku Takeda; Satish K Tickoo; Martin H Voss; James Wren; James J Hsieh
Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma.
Gregory R Bean; Po M Chan; Lewis A Chodosh; Yiyu Dong; Yogesh Tengarai Ganesan; James Hsieh; Yafen Huang; Han Liu; Shugaku Takeda; Gerard P Zambetti; Emily Cheng
PUMA and BIM are required for oncogene inactivation-induced apoptosis.
David Y Chen; Emily Cheng; Yiyu Dong; Richard Gussio; Ann Hermone; Stanley J Korsmeyer; Yishan Lee; Han Liu; Kyoung J Oh; David Piwnica-Worms; Adam C Searleman; Robert H Shoemaker; Shugaku Takeda; Ho-Chou Tu; Brian A Van Tine; Todd D Westergard; James Hsieh
A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth.

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All Publications

2013: A Ari Hakimi; Adriana Heguy; Omar Abdel-Wahab; Ying-bei Chen; Emily Cheng; Jonathan Coleman; Mithat Gonen; Han Liu; Robert J Motzer; Victor E Reuter; Paul Russo; Shugaku Takeda; Satish K Tickoo; Martin H Voss; James Wren; James J Hsieh
Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma.
European urology 2013;63(5):848-54.
2013: Gregory R Bean; Po M Chan; Lewis A Chodosh; Yiyu Dong; Yogesh Tengarai Ganesan; James Hsieh; Yafen Huang; Han Liu; Shugaku Takeda; Gerard P Zambetti; Emily Cheng
PUMA and BIM are required for oncogene inactivation-induced apoptosis.
Science signaling 2013;6(268):ra20.
2012: David Y Chen; Emily Cheng; Yiyu Dong; Richard Gussio; Ann Hermone; Stanley J Korsmeyer; Yishan Lee; Han Liu; Kyoung J Oh; David Piwnica-Worms; Adam C Searleman; Robert H Shoemaker; Shugaku Takeda; Ho-Chou Tu; Brian A Van Tine; Todd D Westergard; James Hsieh
A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth.
Cancer research 2012;72(3):736-46.
2010: Decheng Ren; Ho-Chou Tu; Hyungjin Kim; Gary X Wang; Gregory R Bean; Osamu Takeuchi; John R Jeffers; Gerard P Zambetti; James Hsieh; Emily Cheng
BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.
Science (New York, N.Y.) 2010;330(6009):1390-3.
2010: Han Liu; Shugaku Takeda; Rakesh Kumar; Todd D Westergard; Eric J Brown; Tej K Pandita; Emily Cheng; James Hsieh
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
Nature 2010;467(7313):343-6.
2010: David Y Chen; Han Liu; Shugaku Takeda; Ho-Chou Tu; Satoru Sasagawa; Brian A Van Tine; Dongsi Lu; Emily Cheng; James Hsieh
Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis.
Cancer research 2010;70(13):5358-67.
2010: Yun Chen; William Lewis; Abhinav Diwan; Emily Cheng; Scot J Matkovich; Gerald W Dorn
Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(20):9035-42.
2009: Hyungjin Kim; Ho-Chou Tu; Decheng Ren; Osamu Takeuchi; John R Jeffers; Gerard P Zambetti; James Hsieh; Emily Cheng
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.
Molecular cell 2009;36(3):487-99.
2009: Han Liu; Emily Cheng; James Hsieh
MLL fusions: pathways to leukemia.
Cancer biology & therapy 2009;8(13):1204-11.
2009: Hyungjin Kim; James Hsieh; Emily Cheng
Deadly splicing: Bax becomes Almighty.
Molecular cell 2009;33(2):145-6.
2009: Ho-Chou Tu; Decheng Ren; Gary X Wang; David Y Chen; Todd D Westergard; Hyungjin Kim; Satoru Sasagawa; James Hsieh; Emily Cheng
The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(4):1093-8.
2009: Decheng Ren; Hyungjin Kim; Ho-Chou Tu; Todd D Westergard; Jill K Fisher; Jeff A Rubens; Stanley J Korsmeyer; James Hsieh; Emily Cheng
The VDAC2-BAK rheostat controls thymocyte survival.
Science signaling 2009;2(85):ra48.
2008: Evripidis Gavathiotis; Motoshi Suzuki; Marguerite L Davis; Kenneth Pitter; Gregory H Bird; Samuel G Katz; Ho-Chou Tu; Hyungjin Kim; Emily Cheng; Nico Tjandra; Loren D Walensky
BAX activation is initiated at a novel interaction site.
Nature 2008;455(7216):1076-81.
2008: Jimmy A Rotolo; Jerzy Maj; Regina Feldman; Decheng Ren; Adriana Haimovitz-Friedman; Carlos Cordon-Cardo; Emily Cheng; Richard Kolesnick; Zvi Fuks
Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa.
International journal of radiation oncology, biology, physics 2008;70(3):804-15.
2008: Han Liu; Shugaku Takeda; Emily Cheng; James Hsieh
Biphasic MLL takes helm at cell cycle control: implications in human mixed lineage leukemia.
Cell cycle (Georgetown, Tex.) 2008;7(4):428-35.
2007: Han Liu; Emily Cheng; James Hsieh
Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions.
Genes & development 2007;21(19):2385-98.
2006: Hyungjin Kim; Mubina Rafiuddin-Shah; Ho-Chou Tu; John R Jeffers; Gerard P Zambetti; James Hsieh; Emily Cheng
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.
Nature cell biology 2006;8(12):1348-58.
2006: Shugaku Takeda; David Y Chen; Todd D Westergard; Jill K Fisher; Jeffrey A Rubens; Satoru Sasagawa; Jason T Kan; Stanley J Korsmeyer; Emily Cheng; James Hsieh
Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.
Genes & development 2006;20(17):2397-409.
2005: Antonio Ruiz-Vela; Joseph T Opferman; Emily Cheng; Stanley J Korsmeyer
Proapoptotic BAX and BAK control multiple initiator caspases.
EMBO reports 2005;6(4):379-85.
2003: James Hsieh; Emily Cheng; Stanley J Korsmeyer
Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.
Cell 2003;115(3):293-303.
2003: Emily Cheng; Tatiana V Sheiko; Jill K Fisher; William J Craigen; Stanley J Korsmeyer
VDAC2 inhibits BAK activation and mitochondrial apoptosis.
Science (New York, N.Y.) 2003;301(5632):513-7.
2003: LUCA SCORRANO; Scott A Oakes; Joseph T Opferman; Emily Cheng; Mia D Sorcinelli; Tullio Pozzan; Stanley J Korsmeyer
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.
Science (New York, N.Y.) 2003;300(5616):135-9.
2001: Evgeny V Pavlov; Muriel Priault; Dawn Pietkiewicz; Emily Cheng; Bruno Antonsson; Stéphen Manon; Stanley J Korsmeyer; Carmen A Mannella; Kathleen W Kinnally
A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast.
The Journal of cell biology 2001;155(5):725-31.
2001: Emily Cheng; Michael Wei; Solly Weiler; R A Flavell; T W Mak; Tullia Lindsten; Stanley J Korsmeyer
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.
Molecular cell 2001;8(3):705-11.
2001: Michael Wei; Wei-Xing Zong; Emily Cheng; Tullia Lindsten; V Panoutsakopoulou; AJ Ross; Kevin A Roth; Grant R MacGregor; Craig Thompson; Stanley J Korsmeyer
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death.
Science (New York, N.Y.) 2001;292(5517):727-30.
2000: BN Chau; Emily Cheng; Douglas A Kerr; J Marie Hardwick
Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.
Molecular cell 2000;6(1):31-40.
1998: RJ Clem; Emily Cheng; C L Karp; D G Kirsch; K Ueno; A Takahashi; M B Kastan; Diane E Griffin; W C Earnshaw; MA Veliuona; J Marie Hardwick
Modulation of cell death by Bcl-XL through caspase interaction.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):554-9.
1997: Emily Cheng; D G Kirsch; RJ Clem; Rajani Ravi; M B Kastan; Atul Bedi; K Ueno; J Marie Hardwick
Conversion of Bcl-2 to a Bax-like death effector by caspases.
Science (New York, N.Y.) 1997;278(5345):1966-8.
1997: Victor E Nava; Emily Cheng; MA Veliuona; S Zou; RJ Clem; M L Mayer; J Marie Hardwick
Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene.
Journal of virology 1997;71(5):4118-22.
1997: Emily Cheng; John Nicholas; David S Bellows; Gary S Hayward; Hong-Guang Guo; Marvin Reitz; J Marie Hardwick
A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):690-4.
1996: Emily Cheng; Beth Levine; Lawrence Boise; Craig Thompson; J Marie Hardwick
Bax-independent inhibition of apoptosis by Bcl-XL.
Nature 1996;379(6565):554-6.
1991: B Shank; Thomas LoSasso; L Brewster; Chandra M Burman; Emily Cheng; James C H Chu; Robert E Drzymala; J Manolis; M V Pilepich; Lawrence J Solin
Three-dimensional treatment planning for postoperative treatment of rectal carcinoma.
International journal of radiation oncology, biology, physics 1991;21(1):253-65.
1991: Joseph R Simpson; James A Purdy; J M Manolis; M V Pilepich; Chandra M Burman; Jeffrey D Forman; Zvi Fuks; Emily Cheng; J Chu; J Matthews
Three-dimensional treatment planning considerations for prostate cancer.
International journal of radiation oncology, biology, physics 1991;21(1):243-52.
1991: John E Munzenrider; K P Doppke; A P Brown; Chandra M Burman; Emily Cheng; J Chu; Chen-Shou Chui; Robert E Drzymala; Michael Goitein; J M Manolis
Three-dimensional treatment planning for para-aortic node irradiation in patients with cervical cancer.
International journal of radiation oncology, biology, physics 1991;21(1):229-42.
1991: Bahman Emami; James A Purdy; J Manolis; G Barest; Emily Cheng; Lawrence R Coia; K Doppke; J Galvin; Thomas LoSasso; J Matthews
Three-dimensional treatment planning for lung cancer.
International journal of radiation oncology, biology, physics 1991;21(1):217-27.
1991: Gerald J Kutcher; Zvi Fuks; H Brenner; A P Brown; Chandra M Burman; Emily Cheng; Lawrence R Coia; K Krippner; J M Manolis; R Mohan
Three-dimensional photon treatment planning for carcinoma of the nasopharynx.
International journal of radiation oncology, biology, physics 1991;21(1):169-82.