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Michael Smith, Jr.

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Maya Arai; Sadhana Jain; Amy A Weaver; Andrew A Hill; Yongjing Guo; Andrea G Bree; Michael Smith, Jr.; Scott W Allen; Edward R LaVallie; Deborah Young; Laird Bloom; Karissa Adkins; Margot O'Toole
Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood.
Michael Smith, Jr.; Falk Hiepe; Thomas Dörner; Gerd Burmester
Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis.
Song-Ze Ding; Igor N Olekhnovich; Timothy L Cover; Richard M Peek; Michael Smith, Jr.; Joanna B Goldberg
Helicobacter pylori and mitogen-activated protein kinases mediate activator protein-1 (AP-1) subcomponent protein expression and DNA-binding activity in gastric epithelial cells.

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All Publications

2010: Maya Arai; Sadhana Jain; Amy A Weaver; Andrew A Hill; Yongjing Guo; Andrea G Bree; Michael Smith, Jr.; Scott W Allen; Edward R LaVallie; Deborah Young; Laird Bloom; Karissa Adkins; Margot O'Toole
Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood.
Journal of translational medicine 2010;8():51.
2009: Michael Smith, Jr.; Falk Hiepe; Thomas Dörner; Gerd Burmester
Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis.
Arthritis research & therapy 2009;11(6):255.
2008: Song-Ze Ding; Igor N Olekhnovich; Timothy L Cover; Richard M Peek; Michael Smith, Jr.; Joanna B Goldberg
Helicobacter pylori and mitogen-activated protein kinases mediate activator protein-1 (AP-1) subcomponent protein expression and DNA-binding activity in gastric epithelial cells.
FEMS immunology and medical microbiology 2008;53(3):385-94.
2008: Song-Ze Ding; Michael Smith, Jr.; Joanna B Goldberg
Helicobacter pylori and mitogen-activated protein kinases regulate the cell cycle, proliferation and apoptosis in gastric epithelial cells.
Journal of gastroenterology and hepatology 2008;23(7 Pt 2):e67-78.
2007: John B Schell; Courtney A Crane; Michael Smith, Jr.; Margo R Roberts
Differential ex vivo nitric oxide production by acutely isolated neonatal and adult microglia.
Journal of neuroimmunology 2007;189(1-2):75-87.
2006: Ann M O'Hara; Asima Bhattacharyya; Randy C Mifflin; Michael Smith, Jr.; Kieran A Ryan; Kevin G-E Scott; Makoto Naganuma; Antonella Casola; Tadahide Izumi; Sankar Mitra; Peter B Ernst; Sheila E Crowe
Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7990-9.
2006: Jitendra K Gautam; Laurey D Comeau; Joanna K Krueger; Michael Smith, Jr.
Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling.
The Journal of biological chemistry 2006;281(40):30132-42.
2006: Michael Smith, Jr.; Jennifer Novotny; Virginia S Carl; Laurey D Comeau
Helicobacter pylori and toll-like receptor agonists induce syndecan-4 expression in an NF-kappaB-dependent manner.
Glycobiology 2006;16(3):221-9.
2006: Michael Smith, Jr.; Jitendra K Gautam; Steven G Black; Peter B Ernst
Microbial-induced regulation of syndecan expression: important host defense mechanism or an opportunity for pathogens?
TheScientificWorldJournal 2006;6():442-5.
2005: Molly A Hughes; Candace S Green; Lisa Lowchyj; Gloria M Lee; Vanessa K Grippe; Michael Smith, Jr.; Li-Yun Huang; Eric T Harvill; Tod J Merkel
MyD88-dependent signaling contributes to protection following Bacillus anthracis spore challenge of mice: implications for Toll-like receptor signaling.
Infection and immunity 2005;73(11):7535-40.
2005: Song-Ze Ding; Anastasia M Torok; Michael Smith, Jr.; Joanna B Goldberg
Toll-like receptor 2-mediated gene expression in epithelial cells during Helicobacter pylori infection.
Helicobacter 2005;10(3):193-204.
2004: Virginia S Carl; Jitendra K Gautam; Laurey D Comeau; Michael Smith, Jr.
Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression.
Journal of leukocyte biology 2004;76(3):735-42.
2004: Kieran A Ryan; Michael Smith, Jr.; Michael K Sanders; Peter B Ernst
Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF-kappa B and interleukin-8 expression.
Infection and immunity 2004;72(4):2123-30.
2003: Michael Smith, Jr.; Anastasia Mitchell; Guolian Li; Song Ding; Ann Marie Fitzmaurice; Kieran Ryan; Sheila Crowe; Joanna B Goldberg
Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells.
The Journal of biological chemistry 2003;278(35):32552-60.
2003: Kosuke Kozaiwa; Kazuhiko Sugawara; Michael Smith, Jr.; Virginia S Carl; Vladimir Yamschikov; Brian Belyea; Sherri B McEwen; Christopher A Moskaluk; Theresa T Pizarro; Fabio Cominelli; Marcia McDuffie
Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFc.
Gastroenterology 2003;125(2):477-90.
2003: Stuart S Berr; James K Roche; Wa'el El-Rifai; Michael Smith, Jr.; Steven M Powell
Magnetic resonance imaging of gastric cancer in Tff1 knock-out mice.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2003;49(6):1033-6.
2003: Dajun Deng; Wa'el El-Rifai; Jiafu Ji; Budong Zhu; Paul Trampont; Jiyou Li; Michael Smith, Jr.; Steven M Powel
Hypermethylation of metallothionein-3 CpG island in gastric carcinoma.
Carcinogenesis 2003;24(1):25-9.
2002: Wa'el El-Rifai; Michael Smith, Jr.; Guolian Li; Andy Beckler; Virginia S Carl; Elizabeth Montgomery; Sakari Knuutila; Christopher A Moskaluk; Henry F Frierson; Steven M Powell
Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP.
Cancer research 2002;62(14):4061-4.
2002: Virginia S Carl; Kathleen Brown-Steinke; Martin J H Nicklin; Michael Smith, Jr.
Toll-like receptor 2 and 4 (TLR2 and TLR4) agonists differentially regulate secretory interleukin-1 receptor antagonist gene expression in macrophages.
The Journal of biological chemistry 2002;277(20):17448-56.
2002: Dajun Deng; Guoren Deng; Michael Smith, Jr.; Jing Zhou; Huijun Xin; Steven M Powell; Youyong Lu
Simultaneous detection of CpG methylation and single nucleotide polymorphism by denaturing high performance liquid chromatography.
Nucleic acids research 2002;30(3):E13.
2001: Michael Smith, Jr.; S Delbary-Gossart
Electrophoretic Mobility Shift Assay (EMSA).
Methods in molecular medicine 2001;50():249-57.
1999: K K Jefferson; Michael Smith, Jr.; DA Bobak
Roles of intracellular calcium and NF-kappa B in the Clostridium difficile toxin A-induced up-regulation and secretion of IL-8 from human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5183-91.
1999: C Gabay; Michael Smith, Jr.; William P Arend
The human intracellular interleukin 1 receptor antagonist promoter appropriately regulates gene expression in keratinocytes and gastrointestinal epithelial cells in vivo.
Cytokine 1999;11(8):561-70.
1999: Theresa T Pizarro; M H Michie; M Bentz; J Woraratanadharm; Michael Smith, Jr.; Eugene F Foley; Christopher A Moskaluk; Stephen Bickston; Fabio Cominelli
IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6829-35.
1998: Michael Smith, Jr.; Virginia S Carl; TA Lodie; M J Fenton
Secretory interleukin-1 receptor antagonist gene expression requires both a PU.1 and a novel composite NF-kappaB/PU.1/ GA-binding protein binding site.
The Journal of biological chemistry 1998;273(37):24272-9.
1998: M Malyak; Michael Smith, Jr.; A A Abel; K R Hance; William P Arend
The differential production of three forms of IL-1 receptor antagonist by human neutrophils and monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):2004-10.
1997: Harold Dickensheets; S L Freeman; Michael Smith, Jr.; Raymond P Donnelly
Interleukin-10 upregulates tumor necrosis factor receptor type-II (p75) gene expression in endotoxin-stimulated human monocytes.
Blood 1997;90(10):4162-71.
1997: C Gabay; Michael Smith, Jr.; D Eidlen; William P Arend
Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein.
The Journal of clinical investigation 1997;99(12):2930-40.
1997: Carla Guthridge; D Eidlen; William P Arend; Arthur Gutierrez-Hartmann; Michael Smith, Jr.
Lipopolysaccharide and Raf-1 kinase regulate secretory interleukin-1 receptor antagonist gene expression by mutually antagonistic mechanisms.
Molecular and cellular biology 1997;17(3):1118-28.
1997: J K Jenkins; RF Drong; ME Shuck; Michael J Bienkowski; Jerry L Slightom; William P Arend; Michael Smith, Jr.
Intracellular IL-1 receptor antagonist promoter: cell type-specific and inducible regulatory regions.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):748-55.
1996: Yoshihiro Ohmori; Michael Smith, Jr.; Thomas Hamilton
IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(5):2058-65.
1995: Carlton C Barnett; Ernest E Moore; Frederick A Moore; Walter L Biffl; Michael Smith, Jr.; V S Carl
Intercellular adhesion molecule-1 promotes neutrophil-mediated cytotoxicity.
Surgery 1995;118(2):171-5; discussion 176.
1994: William P Arend; M Malyak; Michael Smith, Jr.; T D Whisenand; JL Slack; John E Sims; Judith Goldstein Giri; Steven K Dower
Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(10):4766-74.
1994: Michael Smith, Jr.; D Eidlen; William P Arend; Arthur Gutierrez-Hartmann
LPS-induced expression of the human IL-1 receptor antagonist gene is controlled by multiple interacting promoter elements.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3584-93.
1994: M Malyak; Michael Smith, Jr.; A A Abel; William P Arend
Peripheral blood neutrophil production of interleukin-1 receptor antagonist and interleukin-1 beta.
Journal of clinical immunology 1994;14(1):20-30.
1993: D Patterson; C Jones; I Hart; J Bleskan; R Berger; D Geyer; S P Eisenberg; Michael Smith, Jr.; William P Arend
The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region.
Genomics 1993;15(1):173-6.
1992: Michael Smith, Jr.; D Eidlen; M T Brewer; S P Eisenberg; William P Arend; Arthur Gutierrez-Hartmann
Human IL-1 receptor antagonist promoter. Cell type-specific activity and identification of regulatory regions.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(6):2000-7.
1991: Michael Smith, Jr.; F Kueppers; J C Lee
Differential regulation of interleukin-1 alpha and interleukin-1 beta mRNA expression in human monocytes: evidence for protein kinase C-dependent and -independent pathways.
Lymphokine and cytokine research 1991;10(5):397-403.
1991: William P Arend; Michael Smith, Jr.; R W Janson; F G Joslin
IL-1 receptor antagonist and IL-1 beta production in human monocytes are regulated differently.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(5):1530-6.
1991: William P Arend; M Malyak; C F Bigler; Michael Smith, Jr.; R W Janson
The biological role of naturally-occurring cytokine inhibitors.
British journal of rheumatology 1991;30 Suppl 2():49-52.
1989: Michael Smith, Jr.; F R Kueppers; Peter Young; J C Lee
A rapid and quantitative method for the determination of interleukin-1 alpha and -beta mRNA expression in human monocytes and macrophages.
Journal of immunological methods 1989;118(2):265-72.
1987: J C Lee; A Truneh; Michael Smith, Jr.; K Y Tsang
Induction of interleukin 2 receptor (TAC) by tumor necrosis factor in YT cells.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(6):1935-8.