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Paul Janssen

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Disorders

Myocardial Contraction

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TOP 3
Steve R Roof; Brandon J Biesiadecki; Jonathan P Davis; Paul Janssen; Mark T Ziolo
Effects of increased systolic Ca(2+) and β-adrenergic stimulation on Ca(2+) transient decline in NOS1 knockout cardiac myocytes.
Dawn A Delfín; Paul Janssen; Nikita T Patel; Subha V Raman; Kevin E Schill; Kara E Zang; Jill A Rafael-Fortney
Cardiomyopathy in the dystrophin/utrophin-deficient mouse model of severe muscular dystrophy is characterized by dysregulation of matrix metalloproteinases.
Kaylan M Haizlip; Nitisha Hiranandani; Brandon J Biesiadecki; Paul Janssen
Impact of hydroxyl radical-induced injury on calcium handling and myofilament sensitivity in isolated myocardium.

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2012: Steve R Roof; Brandon J Biesiadecki; Jonathan P Davis; Paul Janssen; Mark T Ziolo
Effects of increased systolic Ca(2+) and β-adrenergic stimulation on Ca(2+) transient decline in NOS1 knockout cardiac myocytes.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2012;27(4):242-7.
2012: Dawn A Delfín; Paul Janssen; Nikita T Patel; Subha V Raman; Kevin E Schill; Kara E Zang; Jill A Rafael-Fortney
Cardiomyopathy in the dystrophin/utrophin-deficient mouse model of severe muscular dystrophy is characterized by dysregulation of matrix metalloproteinases.
Neuromuscular disorders : NMD 2012;22(11):1006-14.
2012: Kaylan M Haizlip; Nitisha Hiranandani; Brandon J Biesiadecki; Paul Janssen
Impact of hydroxyl radical-induced injury on calcium handling and myofilament sensitivity in isolated myocardium.
Journal of applied physiology (Bethesda, Md. : 1985) 2012;113(5):766-74.
2012: Sean C Little; Brandon J Biesiadecki; Robert S D Higgins; Paul Janssen; Ahmet Kilic; Jonathan P Davis
The rates of Ca2+ dissociation and cross-bridge detachment from ventricular myofibrils as reported by a fluorescent cardiac troponin C.
The Journal of biological chemistry 2012;287(33):27930-40.
2012: Dawn A Delfín; Paul Janssen; Tessily A Mays; Jamie A Barnum; Benjamin D Canan; Kevin E Schill; Ying Xu; Kara E Zang; Jill A Rafael-Fortney
Sustaining cardiac claudin-5 levels prevents functional hallmarks of cardiomyopathy in a muscular dystrophy mouse model.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(7):1378-83.
2012: Kaylan M Haizlip; Brandon J Biesiadecki; Tepmanas Bupha-Intr; Paul Janssen
Effects of increased preload on the force-frequency response and contractile kinetics in early stages of cardiac muscle hypertrophy.
American journal of physiology. Heart and circulatory physiology 2012;302(12):H2509-17.
2012: Jessica L Slabaugh; Lucia Brunello; Sandor Gyorke; Paul Janssen
Contractile parameters and occurrence of alternans in isolated rat myocardium at supra-physiological stimulation frequency.
American journal of physiology. Heart and circulatory physiology 2012;302(11):H2267-75.
2012: Nadine Bakkar; Naresh C Bal; Benjamin D Canan; Paul Janssen; Katherine J Ladner; Qiutang Li; Sandya Liyanarachchi; Meghna Pant; Muthu Periasamy; Denis C Guttridge
IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.
The Journal of cell biology 2012;196(4):497-511.
2012: Mohammad T Elnakish; Mazin A Alhaj; Mohamed D H Hassona; Paul Janssen; Mahmood Khan; Leni Moldovan; Hamdy H Hassanain
Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis.
PloS one 2012;7(8):e42500.
2012: Tepmanas Bupha-Intr; Kaylan M Haizlip; Paul Janssen
Role of endothelin in the induction of cardiac hypertrophy in vitro.
PloS one 2012;7(8):e43179.
2012: William E Grose; Paul Janssen; Sarah Lewis; Vinod Malik; Jerry R Mendell; Chrystal L Montgomery; Robert H Brown; K Reed Clark; Danielle Griffin; Kimberly M Shontz; Louise Rodino-Klapac
Homologous recombination mediates functional recovery of dysferlin deficiency following AAV5 gene transfer.
PloS one 2012;7(6):e39233.
2012: Kenneth D Varian; Mark T Ziolo; Brandon J Biesiadecki; Jonathan P Davis; Paul Janssen
Staurosporine inhibits frequency-dependent myofilament desensitization in intact rabbit cardiac trabeculae.
Biochemistry research international 2012;2012():290971.
2011: Nicholas Beastrom; Benjamin D Canan; Paul Janssen; Eric K Johnson; Brian K Kaspar; Haiyan Lu; Allison Macke; Christopher M Penton; Louise Rodino-Klapac; Lan Zhou; Federica Montanaro
mdx(⁵cv) mice manifest more severe muscle dysfunction and diaphragm force deficits than do mdx Mice.
The American journal of pathology 2011;179(5):2464-74.
2011: Ying Xu; Michelle M Monasky; George E Billman; Kaylan M Haizlip; Nitisha Hiranandani; Paul Janssen
Effect of twitch interval duration on the contractile function of subsequent twitches in isolated rat, rabbit, and dog myocardium under physiological conditions.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;111(4):1159-67.
2011: Steve R Roof; Thomas R Shannon; Paul Janssen; Mark T Ziolo
Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.
American journal of physiology. Heart and circulatory physiology 2011;301(4):H1570-8.
2011: Jill A Rafael-Fortney; Kevin E Schill; Jenna E Stangland; Tam Tran; Ying Xu; Benjamin D Canan; Neeraj S Chimanji; Dawn A Delfín; Ranjit Ganguly; Paul Janssen; Christopher D Martin; Tessily A Mays; Jason D Murray; Subha V Raman
Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice.
Circulation 2011;124(5):582-8.
2011: Jennifer M Peterson; Jill A Rafael-Fortney; Daniel J Ricca; Paul D Robbins; Brian Kaspar; Pravin Kaumaya; William Kline; Joe N Kornegay; Jerry R Mendell; Albert S Baldwin; Benjamin D Canan; Paula R Clemens; Dawn A Delfín; Kelly DiRienzo; Pat Flood; Michael Freitas; Denis C Guttridge; Paul Janssen
Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy.
Molecular medicine (Cambridge, Mass.) 2011;17(5-6):508-15.
2011: Ying Xu; Dawn A Delfín; Jill A Rafael-Fortney; Paul Janssen
Lengthening-contractions in isolated myocardium impact force development and worsen cardiac contractile function in the mdx mouse model of muscular dystrophy.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;110(2):512-9.
2011: Carlos A A Torres; Paul Janssen
Contractile strength during variable heart duration is species and preload dependent.
Journal of biomedicine & biotechnology 2011;2011():294204.
2011: Kaylan M Haizlip; Paul Janssen
In vitro studies of early cardiac remodeling: impact on contraction and calcium handling.
Frontiers in bioscience (Scholar edition) 2011;3():1047-57.
2011: Dawn A Delfín; Denis C Guttridge; Jennifer M Peterson; Jill A Rafael-Fortney; Ying Xu; Paul Janssen
Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy.
Journal of translational medicine 2011;9():68.
2010: Paul Janssen
Myocardial contraction-relaxation coupling.
American journal of physiology. Heart and circulatory physiology 2010;299(6):H1741-9.
2010: Paul Janssen
Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere.
American journal of physiology. Heart and circulatory physiology 2010;299(4):H1092-9.
2010: Tennore Ramesh; Alison N Lyon; Ricardo H Pineda; Chunping Wang; Paul Janssen; Benjamin D Canan; Arthur H M Burghes; Christine E Beattie
A genetic model of amyotrophic lateral sclerosis in zebrafish displays phenotypic hallmarks of motoneuron disease.
Disease models & mechanisms 2010;3(9-10):652-62.
2010: Kumaran Chandrasekharan; Jung Hae Yoon; Ying Xu; Sarah deVries; Marybeth Camboni; Paul Janssen; Ajit Varki; Paul T Martin
A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy.
Science translational medicine 2010;2(42):42ra54.
2010: Michelle M Monasky; Brandon J Biesiadecki; Paul Janssen
Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions.
Journal of molecular and cellular cardiology 2010;48(5):1023-8.
2010: George E Billman; Yoshinori Nishijima; Andriy Belevych; Dmitry Terentyev; Ying Xu; Kaylan M Haizlip; Michelle M Monasky; Nitisha Hiranandani; William S Harris; Sandor Gyorke; Cynthia A Carnes; Paul Janssen
Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies.
American journal of physiology. Heart and circulatory physiology 2010;298(4):H1219-28.
2010: Nitisha Hiranandani; George E Billman; Paul Janssen
Effects of hydroxyl radical induced-injury in atrial versus ventricular myocardium of dog and rabbit.
Frontiers in physiology 2010;1():25.
2010: Paul Janssen
Challenges in cardiac muscle physiology.
Frontiers in physiology 2010;1():2.
2010: Mark J Kohr; Nina Kaludercic; Carlo G Tocchetti; Wei Dong Gao; David A Kass; Paul Janssen; Nazareno Paolocci; Mark T Ziolo
Nitroxyl enhances myocyte Ca2+ transients by exclusively targeting SR Ca2+-cycling.
Frontiers in bioscience (Elite edition) 2010;2():614-26.
2009: Janaiah Kota; Chalonda R Handy; Amanda M Haidet; Chrystal L Montgomery; Amy Eagle; Louise R Rodino-Klapac; Danielle Tucker; Christopher J Shilling; Walter R Therlfall; Christopher M Walker; Steven E Weisbrode; Paul Janssen; K Reed Clark; Zarife Sahenk; Jerry R Mendell; Brian K Kaspar
Follistatin gene delivery enhances muscle growth and strength in nonhuman primates.
Science translational medicine 2009;1(6):6ra15.
2009: Kenneth D Varian; Ying Xu; Carlos A A Torres; Michelle M Monasky; Paul Janssen
A random cycle length approach for assessment of myocardial contraction in isolated rabbit myocardium.
American journal of physiology. Heart and circulatory physiology 2009;297(5):H1940-8.
2009: Kenneth D Varian; Anusak kijtawornrat; Subash C Gupta; Carlos A A Torres; Michelle M Monasky; Nitisha Hiranandani; Dawn A Delfin; Jill A Rafael-Fortney; Muthu Periasamy; Robert L Hamlin; Paul Janssen
Impairment of diastolic function by lack of frequency-dependent myofilament desensitization rabbit right ventricular hypertrophy.
Circulation. Heart failure 2009;2(5):472-81.
2009: Subash C Gupta; Kenneth D Varian; Naresh C Bal; Jessica L Abraham; Muthu Periasamy; Paul Janssen
Pulmonary artery banding alters the expression of Ca2+ transport proteins in the right atrium in rabbits.
American journal of physiology. Heart and circulatory physiology 2009;296(6):H1933-9.
2009: Michelle M Monasky; Paul Janssen
The positive force-frequency relationship is maintained in absence of sarcoplasmic reticulum function in rabbit, but not in rat myocardium.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 2009;179(4):469-79.
2009: Tepmanas Bupha-Intr; Kaylan M Haizlip; Paul Janssen
Temporal changes in expression of connexin 43 after load-induced hypertrophy in vitro.
American journal of physiology. Heart and circulatory physiology 2009;296(3):H806-14.
2009: Paul T Martin; Rui Xu; Louise R Rodino-Klapac; Elaine Oglesbay; Marybeth Camboni; Chrystal L Montgomery; Kim Shontz; Louis G Chicoine; K Reed Clark; Zarife Sahenk; Jerry R Mendell; Paul Janssen
Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice.
American journal of physiology. Cell physiology 2009;296(3):C476-88.
2009: Paul Janssen; O Zeitz; H Schumann; J Holtz; G Hasenfuss
Load-induced cardiomyocyte apoptosis in cultured multicellular myocardial preparations is unaltered in presence of the beta-adrenoceptor antagonist nebivolol.
Pharmacology 2009;83(3):141-7.
2008: Jamie L Sanford; Tessily A Mays; Kenneth D Varian; Joanna B Wilson; Paul Janssen; Jill A Rafael-Fortney
Truncated CASK does not alter skeletal muscle or protein interactors.
Muscle & nerve 2008;38(3):1116-27.
2008: Tessily A Mays; philip binkley; Amanda Lesinski; Amit A Doshi; Michael P Quaile; Kenneth B Margulies; Paul Janssen; Jill A Rafael-Fortney
Claudin-5 levels are reduced in human end-stage cardiomyopathy.
Journal of molecular and cellular cardiology 2008;45(1):81-7.
2008: Honglan Wang; Mark J Kohr; Christopher J Traynham; Debra G Wheeler; Paul Janssen; Mark T Ziolo
Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban.
American journal of physiology. Cell physiology 2008;294(6):C1566-75.
2008: Michelle M Monasky; Kenneth D Varian; Jonathan P Davis; Paul Janssen
Dissociation of force decline from calcium decline by preload in isolated rabbit myocardium.
Pflügers Archiv : European journal of physiology 2008;456(2):267-76.
2008: Michelle M Monasky; Kenneth D Varian; Paul Janssen
Gender comparison of contractile performance and beta-adrenergic response in isolated rat cardiac trabeculae.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 2008;178(3):307-13.
2008: Carlos A A Torres; Kenneth D Varian; Paul Janssen
Variability in interbeat duration influences myocardial contractility in rat cardiac trabeculae.
The open cardiovascular medicine journal 2008;2():100-4.
2008: Muthu Periasamy; Paul Janssen
Molecular basis of diastolic dysfunction.
Heart failure clinics 2008;4(1):13-21.
2007: Tepmanas Bupha-Intr; Jeffrey W Holmes; Paul Janssen
Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium.
American journal of physiology. Heart and circulatory physiology 2007;293(6):H3759-67.
2007: Kathryn A Guterl; Charles R Haggart; Paul Janssen; Jeffrey W Holmes
Isometric contraction induces rapid myocyte remodeling in cultured rat right ventricular papillary muscles.
American journal of physiology. Heart and circulatory physiology 2007;293(6):H3707-12.
2007: Paul Janssen; Muthu Periasamy
Determinants of frequency-dependent contraction and relaxation of mammalian myocardium.
Journal of molecular and cellular cardiology 2007;43(5):523-31.
2007: Cynthia A Carnes; Paul Janssen; Mary L Ruehr; Hitomi Nakayama; Tomohiro Nakayama; Hannelore Haase; John Anthony Bauer; Mina K Chung; Ian M Fearon; A Marc Gillinov; Robert L Hamlin; David Van Wagoner
Atrial glutathione content, calcium current, and contractility.
The Journal of biological chemistry 2007;282(38):28063-73.
2007: Boris Keweloh; Paul Janssen; Ulf Siegel; Nicolin Datz; Oliver Zeitz; Hans-Peter Hermann
Influence of pyruvate on economy of contraction in isolated rabbit myocardium.
European journal of heart failure 2007;9(8):754-61.
2007: Nitisha Hiranandani; Sripriya Raman; Anuradha Kalyanasundaram; Muthu Periasamy; Paul Janssen
Frequency-dependent contractile strength in mice over- and underexpressing the sarco(endo)plasmic reticulum calcium-ATPase.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(1):R30-6.
2007: Kenneth D Varian; Paul Janssen
Frequency-dependent acceleration of relaxation involves decreased myofilament calcium sensitivity.
American journal of physiology. Heart and circulatory physiology 2007;292(5):H2212-9.
2007: Swarnali Acharyya; S Armando Villalta; Nadine Bakkar; Tepmanas Bupha-Intr; Paul Janssen; Micheal Carathers; Zhi-Wei Li; Amer A Beg; Sankar Ghosh; Zarife Sahenk; Michael Weinstein; Katherine L Gardner; Jill A Rafael-Fortney; Michael Karin; James G Tidball; Albert S Baldwin; Denis C Guttridge
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.
The Journal of clinical investigation 2007;117(4):889-901.
2007: Louise Rodino-Klapac; Paul Janssen; Chrystal L Montgomery; Brian D Coley; Louis G Chicoine; K Reed Clark; Jerry R Mendell
A translational approach for limb vascular delivery of the micro-dystrophin gene without high volume or high pressure for treatment of Duchenne muscular dystrophy.
Journal of translational medicine 2007;5():45.
2006: Nitisha Hiranandani; Tepmanas Bupha-Intr; Paul Janssen
SERCA overexpression reduces hydroxyl radical injury in murine myocardium.
American journal of physiology. Heart and circulatory physiology 2006;291(6):H3130-5.
2006: Jörg Stypmann; Paul Janssen; Jürgen Prestle; Markus A Engelen; Harald Kögler; Renate Lüllmann-Rauch; Lars Eckardt; Kurt von Figura; Jobst Landgrebe; Anna Mleczko; Paul Saftig
LAMP-2 deficient mice show depressed cardiac contractile function without significant changes in calcium handling.
Basic research in cardiology 2006;101(4):281-91.
2006: Kenneth D Varian; Sripriya Raman; Paul Janssen
Measurement of myofilament calcium sensitivity at physiological temperature in intact cardiac trabeculae.
American journal of physiology. Heart and circulatory physiology 2006;290(5):H2092-7.
2006: Nitisha Hiranandani; Kenneth D Varian; Michelle M Monasky; Paul Janssen
Frequency-dependent contractile response of isolated cardiac trabeculae under hypo-, normo-, and hyperthermic conditions.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;100(5):1727-32.
2006: Linda B Stull; Nitisha Hiranandani; Missy A Kelley; Michelle K Leppo; Eduardo Marban; Paul Janssen
Murine strain differences in contractile function are temperature- and frequency-dependent.
Pflügers Archiv : European journal of physiology 2006;452(2):140-5.
2006: Gopal J Babu; Poornima Bhupathy; Natalia N Petrashevskaya; Honglan Wang; Sripriya Raman; Debra Wheeler; Ganapathy Jagatheesan; David F Wieczorek; Arnold Schwartz; Paul Janssen; Mark T Ziolo; Muthu Periasamy
Targeted overexpression of sarcolipin in the mouse heart decreases sarcoplasmic reticulum calcium transport and cardiac contractility.
The Journal of biological chemistry 2006;281(7):3972-9.
2006: Sripriya Raman; Melissa A Kelley; Paul Janssen
Effect of muscle dimensions on trabecular contractile performance under physiological conditions.
Pflügers Archiv : European journal of physiology 2006;451(5):625-30.
2005: Paul Janssen; Nitisha Hiranandani; Tessily A Mays; Jill A Rafael-Fortney
Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice.
American journal of physiology. Heart and circulatory physiology 2005;289(6):H2373-8.
2005: J Weisser-Thomas; E Dieterich; Paul Janssen; Stephan Schmidt-Schweda; Lars S Maier; Carlota Sumbilla; Burkert Pieske
Method-related effects of adenovirus-mediated LacZ and SERCA1 gene transfer on contractile behavior of cultured failing human cardiomyocytes.
Journal of pharmacological and toxicological methods 2005;51(2):91-103.
2005: Gopal J Babu; Zhaolun Zheng; Poornima Natarajan; Debra Wheeler; Paul Janssen; Muthu Periasamy
Overexpression of sarcolipin decreases myocyte contractility and calcium transient.
Cardiovascular research 2005;65(1):177-86.
2004: Patrick Most; Sven T Pleger; Mirko Völkers; Beatrix Heidt; Melanie Boerries; Dieter Weichenhan; Eva Löffler; Paul Janssen; Andrea D Eckhart; Jeffrey Martini; Matthew L Williams; Hugo A Katus; Andrew Remppis; Walter J Koch
Cardiac adenoviral S100A1 gene delivery rescues failing myocardium.
The Journal of clinical investigation 2004;114(11):1550-63.
2004: Bradley M Palmer; Dimitrios Georgakopoulos; Paul Janssen; Yuan Wang; Norman R Alpert; Diego F Belardi; Samantha Harris; Richard L Moss; Patrick G Burgon; Christine E Seidman; Jonathan G Seidman; David Wayne Maughan; David A Kass
Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening.
Circulation research 2004;94(9):1249-55.
2004: Eiki Takimoto; David G Soergel; Paul Janssen; Linda B Stull; David A Kass; Anne M Murphy
Frequency- and afterload-dependent cardiac modulation in vivo by troponin I with constitutively active protein kinase A phosphorylation sites.
Circulation research 2004;94(4):496-504.
2004: Hans-Peter Hermann; Jordis Arp; Burkert Pieske; Harald Kögler; Steffen Baron; Paul Janssen; Gerd Hasenfuss
Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure.
European journal of heart failure 2004;6(2):213-8.
2004: Eric I Rossman; Rebecca E Petre; Khuram W Chaudhary; Valentino Piacentino; Paul Janssen; John P Gaughan; Steven R Houser; Kenneth B Margulies
Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium.
Journal of molecular and cellular cardiology 2004;36(1):33-42.
2003: Wolfgang Schillinger; A Ohler; Shahriyar Emami; F Müller; Claus Christians; Paul Janssen; Harald Kögler; Nils Teucher; Burkert Pieske; Tim Seidler; Gerd Hasenfuss
The functional effect of adenoviral Na+/Ca2+ exchanger overexpression in rabbit myocytes depends on the activity of the Na+/K+-ATPase.
Cardiovascular research 2003;57(4):996-1003.
2003: Paul Janssen; Linda B Stull; Michelle K Leppo; Ruth A Altschuld; Eduardo Marban
Selective contractile dysfunction of left, not right, ventricular myocardium in the SHHF rat.
American journal of physiology. Heart and circulatory physiology 2003;284(3):H772-8.
2003: Jolanda van der Velden; Zoltán Papp; Nicky M Boontje; Ruud Zaremba; JW de Jong; Paul Janssen; G Hasenfuss; Ger J M Stienen
The effect of myosin light chain 2 dephosphorylation on Ca2+ -sensitivity of force is enhanced in failing human hearts.
Cardiovascular research 2003;57(2):505-14.
2003: Jolanda van der Velden; Zoltán Papp; Nicky M Boontje; Ruud Zaremba; JW de Jong; Paul Janssen; G Hasenfuss; Ger J M Stienen
Myosin light chain composition in non-failing donor and end-stage failing human ventricular myocardium.
Advances in experimental medicine and biology 2003;538():3-15.
2002: Linda B Stull; Michelle K Leppo; Eduardo Marban; Paul Janssen
Physiological determinants of contractile force generation and calcium handling in mouse myocardium.
Journal of molecular and cellular cardiology 2002;34(10):1367-76.
2002: Paul Janssen; Wolfgang Schillinger; J Kevin Donahue; Oliver Zeitz; Shahriyar Emami; Stephan Lehnart; Joachim Weil; Thomas Eschenhagen; Gerd Hasenfuss; Jürgen Prestle
Intracellular beta-blockade: overexpression of Galpha(i2) depresses the beta-adrenergic response in intact myocardium.
Cardiovascular research 2002;55(2):300-8.
2002: Oliver Zeitz; A Eveline Maass; Phuc Van Nguyen; Geerd Hensmann; Harald Kögler; Karsten Möller; Gerd Hasenfuss; Paul Janssen
Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange.
Circulation research 2002;90(9):988-95.
2002: Paul Janssen; Linda B Stull; Eduardo Marban
Myofilament properties comprise the rate-limiting step for cardiac relaxation at body temperature in the rat.
American journal of physiology. Heart and circulatory physiology 2002;282(2):H499-507.
2002: Gerd Hasenfuss; Lars S Maier; Hans-Peter Hermann; Claus Lüers; Mark Hünlich; Oliver Zeitz; Paul Janssen; Burkert Pieske
Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium.
Circulation 2002;105(2):194-9.
2002: Paul Janssen; Gerd Hasenfuss; Oliver Zeitz; Stephan Lehnart; Jürgen Prestle; Dorothea Darmer; Juergen Holtz; H Schumann
Load-dependent induction of apoptosis in multicellular myocardial preparations.
American journal of physiology. Heart and circulatory physiology 2002;282(1):H349-56.
2002: Hans-Peter Hermann; Oliver Zeitz; Stephan Lehnart; Boris Keweloh; Nicolin Datz; Gerd Hasenfuss; Paul Janssen
Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium.
Cardiovascular research 2002;53(1):116-23.
2001: Paul Janssen; Oliver Zeitz; A Rahman; Gerd Hasenfuss
Protective role of nebivolol in hydroxyl radical induced injury.
Journal of cardiovascular pharmacology 2001;38 Suppl 3():S17-23.
2001: Patrick Most; Juliane Bernotat; Philipp Ehlermann; Sven T Pleger; Michael Reppel; M Börries; F Niroomand; B Pieske; Paul Janssen; Thomas Eschenhagen; P Karczewski; Godfrey L Smith; Walter J Koch; Hugo A Katus; Andrew Remppis
S100A1: a regulator of myocardial contractility.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13889-94.
2001: Hendrik Milting; Paul Janssen; Thekla Wangemann; Harald Kögler; E Domeier; Tim Seidler; Kavous Hakim; M Grapow; Oliver Zeitz; Jürgen Prestle; Hans Zerkowski
FK506 does not affect cardiac contractility and adrenergic response in vitro.
European journal of pharmacology 2001;430(2-3):299-304.
2001: S Baudet; Jutta Weisser; A P Janssen; K Beulich; U Bieligk; Burkert Pieske; Jacques Noireaud; Paul Janssen; Gerd Hasenfuss; Jürgen Prestle
Increased basal contractility of cardiomyocytes overexpressing protein kinase C epsilon and blunted positive inotropic response to endothelin-1.
Cardiovascular research 2001;50(3):486-94.
2001: Jürgen Prestle; Paul Janssen; A P Janssen; Oliver Zeitz; Stephan Lehnart; L Bruce; Godfrey L Smith; Gerd Hasenfuss
Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility.
Circulation research 2001;88(2):188-94.
2000: Wolfgang Schillinger; Paul Janssen; Shahriyar Emami; Scott A Henderson; Robert S Ross; Nils Teucher; Oliver Zeitz; Kenneth D Philipson; Jürgen Prestle; Gerd Hasenfuss
Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na(+)-Ca(2+) exchanger.
Circulation research 2000;87(7):581-7.
2000: Paul Janssen; Nicolin Datz; Oliver Zeitz; Gerd Hasenfuss
Levosimendan improves diastolic and systolic function in failing human myocardium.
European journal of pharmacology 2000;404(1-2):191-9.
2000: Stephan Lehnart; Paul Janssen; W M Franz; J Kevin Donahue; JH Lawrence; Eduardo Marban; Jürgen Prestle; Gerd Hasenfuss
Preservation of myocardial function after adenoviral gene transfer in isolated myocardium.
American journal of physiology. Heart and circulatory physiology 2000;279(3):H986-91.
2000: Yoshitaka Tanaka; G Guhde; A Suter; Eeva-Liisa Eskelinen; Dieter Hartmann; Renate Lüllmann-Rauch; Paul Janssen; J Blanz; Kurt von Figura; Paul Saftig
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice.
Nature 2000;406(6798):902-6.
2000: Thomas Wannenburg; G H Heijne; J H Geerdink; H W Van Den Dool; Paul Janssen; Pieter P de Tombe
Cross-bridge kinetics in rat myocardium: effect of sarcomere length and calcium activation.
American journal of physiology. Heart and circulatory physiology 2000;279(2):H779-90.
2000: Hans-Peter Hermann; Oliver Zeitz; Boris Keweloh; Gerd Hasenfuss; Paul Janssen
Pyruvate potentiates inotropic effects of isoproterenol and Ca(2+) in rabbit cardiac muscle preparations.
American journal of physiology. Heart and circulatory physiology 2000;279(2):H702-8.
2000: Oliver Zeitz; A Rahman; Gerd Hasenfuss; Paul Janssen
Impact of beta-adrenoceptor antagonists on myofilament calcium sensitivity of rabbit and human myocardium.
Journal of cardiovascular pharmacology 2000;36(1):126-31.
2000: Paul Janssen; Oliver Zeitz; Boris Keweloh; U Siegel; Lars S Maier; Paul Barckhausen; Burkert Pieske; Jürgen Prestle; Stephan Lehnart; Gerd Hasenfuss
Influence of cyclosporine A on contractile function, calcium handling, and energetics in isolated human and rabbit myocardium.
Cardiovascular research 2000;47(1):99-107.
1999: Paul Janssen; Stephan Lehnart; Jürgen Prestle; Gerd Hasenfuss
Preservation of contractile characteristics of human myocardium in multi-day cell culture.
Journal of molecular and cellular cardiology 1999;31(8):1419-27.
1999: Paul Janssen; Oliver Zeitz; Gerd Hasenfuss
Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: protective effects of nebivolol.
European journal of pharmacology 1999;366(2-3):223-32.
1998: Paul Janssen; Stephan Lehnart; Jürgen Prestle; J C Lynker; P Salfeld; Hanjörg Just; Gerd Hasenfuss
The trabecula culture system: a novel technique to study contractile parameters over a multiday time period.
The American journal of physiology 1998;274(5 Pt 2):H1481-8.
1998: Piet Schiereck; Paul Janssen; P M Jansen; J Schiereck; M van der Leun; Wim Bras; Evert L de Beer
Force generation and shift of mass between myosin and actin in skinned striated muscle fibres at low calcium concentrations.
European biophysics journal : EBJ 1998;27(6):575-81.
1997: Thomas Wannenburg; Paul Janssen; D Fan; Pieter P de Tombe
The Frank-Starling mechanism is not mediated by changes in rate of cross-bridge detachment.
The American journal of physiology 1997;273(5 Pt 2):H2428-35.
1997: Paul Janssen; Pieter P de Tombe
Protein kinase A does not alter unloaded velocity of sarcomere shortening in skinned rat cardiac trabeculae.
The American journal of physiology 1997;273(5 Pt 2):H2415-22.
1997: Paul Janssen; Piet Schiereck; H Honda; T Naya; Y Koiwa
The effect of applied mechanical vibration on two different phases of rat papillary muscle relaxation.
Pflügers Archiv : European journal of physiology 1997;434(6):795-800.
1997: Paul Janssen; Pieter P de Tombe
Uncontrolled sarcomere shortening increases intracellular Ca2+ transient in rat cardiac trabeculae.
The American journal of physiology 1997;272(4 Pt 2):H1892-7.
1996: Paul Janssen; H Honda; Y Koiwa; Kunio Shirato
The effect of diastolic vibration on the relaxation of rat papillary muscle.
Cardiovascular research 1996;32(2):344-50.
1995: P Van Bergen; Paul Janssen; Peter Hoogerhout; Dick J De Wildt; Dirk Versteeg
Cardiovascular effects of gamma-MSH/ACTH-like peptides: structure-activity relationship.
European journal of pharmacology 1995;294(2-3):795-803.
1995: Paul Janssen; William C Hunter
Force, not sarcomere length, correlates with prolongation of isosarcometric contraction.
The American journal of physiology 1995;269(2 Pt 2):H676-85.
1993: Piet Schiereck; Evert L de Beer; B Van Heijst; Paul Janssen; A Van Andel; F Jennekens; A Sontrop; A Bavinck
Ca2+ channel antagonists enhance tension in skinned skeletal and heart muscle fibres.
European journal of pharmacology 1993;249(3):317-24.