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Seamus Martin
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Chemicals & Drugs
Physiology
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19
Adrain, Colin
18
Green, Douglas
13
Cotter, Thomas
11
Creagh, Emma
7
Brumatti, Gabriela
7
Duriez, Patrick
7
McGahon, AJ
6
Slee, EA
5
Murphy, Brona
5
Mahboubi, Artin
5
Amarante-Mendes, Gustavo
4
Delivani, Petrina
3
Brunner, Thomas
3
Kolesnick, Richard
3
Newmeyer, Donald
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All Publications
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2009: Lüthi Alexander U; Cullen Sean P; McNeela Edel A; Duriez Patrick J; Afonina Inna S; Sheridan Clare; Brumatti Gabriela; Taylor Rebecca C; Kersse Kristof; Vandenabeele Peter; Lavelle Ed C; Martin Seamus J
Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.
Immunity 2009;31(1):84-98.
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2009: Cullen S P; Martin S J
Caspase activation pathways: some recent progress.
Cell death and differentiation 2009;16(7):935-8.
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2009: Cullen Sean P; Afonina Inna S; Donadini Roberta; Lüthi Alexander U; Medema Jan Paul; Bird Phillip I; Martin Seamus J
Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing.
The Journal of biological chemistry 2009;284(8):5137-47.
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2009: Creagh Emma M; Brumatti Gabriela; Sheridan Clare; Duriez Patrick J; Taylor Rebecca C; Cullen Sean P; Adrain Colin; Martin Seamus J
Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival.
PloS one 2009;4(3):e5055.
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2008: Walsh John G; Cullen Sean P; Sheridan Clare; Lüthi Alexander U; Gerner Christopher; Martin Seamus J
Executioner caspase-3 and caspase-7 are functionally distinct proteases.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12815-9.
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2008: Sheridan Clare; Delivani Petrina; Cullen Sean P; Martin Seamus J
Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release.
Molecular cell 2008;31(4):570-85.
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2008: Sheridan Clare; Martin Seamus J
Commitment in apoptosis: slightly dead but mostly alive.
Trends in cell biology 2008;18(8):353-7.
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2008: Sheridan Clare; Brumatti Gabriela; Martin Seamus J
Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim.
The Journal of biological chemistry 2008;283(32):22128-35.
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2008: Cullen Sean P; Lüthi Alexander U; Martin Seamus J
Analysis of apoptosis in cell-free systems.
Methods (San Diego, Calif.) 2008;44(3):273-9.
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2008: Brumatti Gabriela; Sheridan Clare; Martin Seamus J
Expression and purification of recombinant annexin V for the detection of membrane alterations on apoptotic cells.
Methods (San Diego, Calif.) 2008;44(3):235-40.
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2008: Martin Seamus J
Getting the measure of apoptosis.
Methods (San Diego, Calif.) 2008;44(3):197-9.
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2008: Taylor Rebecca C; Cullen Sean P; Martin Seamus J
Apoptosis: controlled demolition at the cellular level.
Nature reviews. Molecular cell biology 2008;9(3):231-41.
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2008: Logue Susan E; Martin Seamus J
Caspase activation cascades in apoptosis.
Biochemical Society transactions 2008;36(Pt 1):1-9.
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2008: Martin S J
Improvement by death in immunity.
Cell death and differentiation 2008;15(2):221-2.
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2008: Cullen S P; Martin S J
Mechanisms of granule-dependent killing.
Cell death and differentiation 2008;15(2):251-62.
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2008: Lüthi Alexander U; Cullen Sean P; Martin Seamus J
Two-dimensional gel-based analysis of the demolition phase of apoptosis.
Methods in enzymology 2008;442():343-54.
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2007: Taylor Rebecca C; Brumatti Gabriela; Ito Shu; Hengartner Michael O; Derry W Brent; Martin Seamus J
Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease.
The Journal of biological chemistry 2007;282(20):15011-21.
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2007: Lüthi A U; Martin S J
The CASBAH: a searchable database of caspase substrates.
Cell death and differentiation 2007;14(4):641-50.
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2007: Cullen Sean P; Adrain Colin; Lüthi Alexander U; Duriez Patrick J; Martin Seamus J
Human and murine granzyme B exhibit divergent substrate preferences.
The Journal of cell biology 2007;176(4):435-44.
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2006: Delivani P; Martin S J
Mitochondrial membrane remodeling in apoptosis: an inside story.
Cell death and differentiation 2006;13(12):2007-10.
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2006: Adrain Colin; Brumatti Gabriela; Martin Seamus J
Apoptosomes: protease activation platforms to die from.
Trends in biochemical sciences 2006;31(5):243-7.
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2006: Delivani Petrina; Adrain Colin; Taylor Rebecca C; Duriez Patrick J; Martin Seamus J
Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics.
Molecular cell 2006;21(6):761-73.
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2006: Adrain Colin; Duriez Patrick J; Brumatti Gabriela; Delivani Petrina; Martin Seamus J
The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics.
The Journal of biological chemistry 2006;281(12):8118-25.
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2006: Adrain Colin; Martin Seamus J
Cell biology. Double knockout blow for caspases.
Science (New York, N.Y.) 2006;311(5762):785-6.
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2005: Taylor R C; Adrain C; Martin S J
Proteases, proteasomes and apoptosis: breaking Ub is hard to do.
Cell death and differentiation 2005;12(9):1213-7.
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2005: Kroemer Guido; Martin Seamus J
Caspase-independent cell death.
Nature medicine 2005;11(7):725-30.
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2005: Adrain Colin; Murphy Brona M; Martin Seamus J
Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.
The Journal of biological chemistry 2005;280(6):4663-73.
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2004: Munarriz Eliana; Barcaroli Daniela; Stephanou Anastasis; Townsend Paul A; Maisse Carine; Terrinoni Alessandro; Neale Michael H; Martin Seamus J; Latchman David S; Knight Richard A; Melino Gerry; De Laurenzi Vincenzo
PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73.
Molecular and cellular biology 2004;24(24):10593-610.
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2004: Yang Jiang-Yan; Michod David; Walicki Joël; Murphy Brona M; Kasibhatla Shailaja; Martin Seamus J; Widmann Christian
Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions.
Molecular and cellular biology 2004;24(23):10425-36.
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2004: Martin Seamus J
An Apollon vista of death and destruction.
Nature cell biology 2004;6(9):804-6.
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2004: Adrain Colin; Creagh Emma M; Cullen Sean P; Martin Seamus J
Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man.
The Journal of biological chemistry 2004;279(35):36923-30.
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2004: Murphy Brona M; Creagh Emma M; Martin Seamus J
Interchain proteolysis, in the absence of a dimerization stimulus, can initiate apoptosis-associated caspase-8 activation.
The Journal of biological chemistry 2004;279(35):36916-22.
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2004: Creagh Emma M; Murphy Brona M; Duriez Patrick J; Duckett Colin S; Martin Seamus J
Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins.
The Journal of biological chemistry 2004;279(26):26906-14.
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2004: Hill Michelle M; Adrain Colin; Duriez Patrick J; Creagh Emma M; Martin Seamus J
Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes.
The EMBO journal 2004;23(10):2134-45.
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2004: Twiddy Davina; Brown David G; Adrain Colin; Jukes Rebekah; Martin Seamus J; Cohen Gerald M; MacFarlane Marion; Cain Kelvin
Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex.
The Journal of biological chemistry 2004;279(19):19665-82.
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2004: Brunner Thomas; Martin Seamus J
c-Myc: where death and division collide.
Cell cycle (Georgetown, Tex.) 2004;3(4):456-9.
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2004: Bouchier-Hayes Lisa; Martin Seamus J
CARDINAL roles in apoptosis and NFkappaB activation.
Vitamins and hormones 2004;67():133-47.
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2003: Collingridge D R; Glaser M; Osman S; Barthel H; Hutchinson O C; Luthra S K; Brady F; Bouchier-Hayes L; Martin S J; Workman P; Price P; Aboagye E O
In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope.
British journal of cancer 2003;89(7):1327-33.
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2003: Creagh Emma M; Conroy Helen; Martin Seamus J
Caspase-activation pathways in apoptosis and immunity.
Immunological reviews 2003;193():10-21.
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2003: Creagh Emma M; Martin Seamus J
Cell stress-associated caspase activation: intrinsically complex?
Science's STKE : signal transduction knowledge environment 2003;2003(175):pe11.
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2003: Murphy Brona M; O'Neill Amanda J; Adrain Colin; Watson R William G; Martin Seamus J
The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome C.
The Journal of experimental medicine 2003;197(5):625-32.
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2003: Hill Michelle M; Adrain Colin; Martin Seamus J
Portrait of a killer: the mitochondrial apoptosome emerges from the shadows.
Molecular interventions 2003;3(1):19-26.
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2003: Adrain Colin; Creagh Emma M; Martin Seamus J
Defying death: showing Bcl-2 the way home.
Nature cell biology 2003;5(1):9-11.
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2003: Glaser Matthias; Collingridge David R; Aboagye Eric O; Bouchier-Hayes Lisa; Hutchinson O Clyde; Martin Seamus J; Price Pat; Brady Frank; Luthra Sajinder K
Iodine-124 labelled annexin-V as a potential radiotracer to study apoptosis using positron emission tomography.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2003;58(1):55-62.
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2002: van Loo G; Saelens X; van Gurp M; MacFarlane M; Martin S J; Vandenabeele P
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.
Cell death and differentiation 2002;9(10):1031-42.
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2002: Bouchier-Hayes Lisa; Martin Seamus J
CARD games in apoptosis and immunity.
EMBO reports 2002;3(7):616-21.
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2002: Martin Seamus J
Destabilizing influences in apoptosis: sowing the seeds of IAP destruction.
Cell 2002;109(7):793-6.
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2001: Adrain C; Creagh E M; Martin S J
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2.
The EMBO journal 2001;20(23):6627-36.
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2001: Creagh E M; Martin S J
Caspases: cellular demolition experts.
Biochemical Society transactions 2001;29(Pt 6):696-702.
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2001: Bouchier-Hayes L; Conroy H; Egan H; Adrain C; Creagh E M; MacFarlane M; Martin S J
CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.
The Journal of biological chemistry 2001;276(47):44069-77.
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2001: Adrain C; Martin S J
The mitochondrial apoptosome: a killer unleashed by the cytochrome seas.
Trends in biochemical sciences 2001;26(6):390-7.
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2001: Martin S J
Dealing the CARDs between life and death.
Trends in cell biology 2001;11(5):188-9.
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2001: Adrain C; Martin S J
Search for Drosophila caspases bears fruit: STRICA enters the fray.
Cell death and differentiation 2001;8(4):319-23.
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2001: Slee E A; Adrain C; Martin S J
Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.
The Journal of biological chemistry 2001;276(10):7320-6.
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2000: Slee E A; Keogh S A; Martin S J
Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release.
Cell death and differentiation 2000;7(6):556-65.
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2000: Eléouët J F; Slee E A; Saurini F; Castagné N; Poncet D; Garrido C; Solary E; Martin S J
The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and -7 during TGEV-induced apoptosis.
Journal of virology 2000;74(9):3975-83.
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2000: Keogh S A; Walczak H; Bouchier-Hayes L; Martin S J
Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis.
FEBS letters 2000;471(1):93-8.
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1999: Slee E A; Adrain C; Martin S J
Serial killers: ordering caspase activation events in apoptosis.
Cell death and differentiation 1999;6(11):1067-74.
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1999: Adrain C; Slee E A; Harte M T; Martin S J
Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region.
The Journal of biological chemistry 1999;274(30):20855-60.
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1999: Slee E A; Harte M T; Kluck R M; Wolf B B; Casiano C A; Newmeyer D D; Wang H G; Reed J C; Nicholson D W; Alnemri E S; Green D R; Martin S J
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.
The Journal of cell biology 1999;144(2):281-92.
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1998: Slee E A; Martin S J
Regulation of caspase activation in apoptosis: implications for transformation and drug resistance.
Cytotechnology 1998;27(1-3):309-20.
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1998: Amarante-Mendes G P; Finucane D M; Martin S J; Cotter T G; Salvesen G S; Green D R
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death.
Cell death and differentiation 1998;5(4):298-306.
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1998: Van Antwerp D J; Martin S J; Verma I M; Green D R
Inhibition of TNF-induced apoptosis by NF-kappa B.
Trends in cell biology 1998;8(3):107-11.
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1997: Kluck R M; Martin S J; Hoffman B M; Zhou J S; Green D R; Newmeyer D D
Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.
The EMBO journal 1997;16(15):4639-49.
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1997: Ellerby H M; Martin S J; Ellerby L M; Naiem S S; Rabizadeh S; Salvesen G S; Casiano C A; Cashman N R; Green D R; Bredesen D E
Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(16):6165-78.
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1997: Tan X; Martin S J; Green D R; Wang J Y
Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death.
The Journal of biological chemistry 1997;272(15):9613-6.
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1997: McGahon A J; Brown D G; Martin S J; Amarante-Mendes G P; Cotter T G; Cohen G M; Green D R
Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis: characterization of the apoptotic death.
Cell death and differentiation 1997;4(2):95-104.
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1996: Martin S J; Finucane D M; Amarante-Mendes G P; O'Brien G A; Green D R
Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity.
The Journal of biological chemistry 1996;271(46):28753-6.
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1996: Van Antwerp D J; Martin S J; Kafri T; Green D R; Verma I M
Suppression of TNF-alpha-induced apoptosis by NF-kappaB.
Science (New York, N.Y.) 1996;274(5288):787-9.
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1996: Casiano C A; Martin S J; Green D R; Tan E M
Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis.
The Journal of experimental medicine 1996;184(2):765-70.
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1996: Green D R; Martin S J
Educational Corner: The ICE/Ced-3-family proteases as the apoptotic executioner.
Cell death and differentiation 1996;3(3):339-40.
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1996: Santana P; Peña L A; Haimovitz-Friedman A; Martin S; Green D; McLoughlin M; Cordon-Cardo C; Schuchman E H; Fuks Z; Kolesnick R
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.
Cell 1996;86(2):189-99.
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1996: Meisenholder G W; Martin S J; Green D R; Nordberg J; Babior B M; Gottlieb R A
Events in apoptosis. Acidification is downstream of protease activation and BCL-2 protection.
The Journal of biological chemistry 1996;271(27):16260-2.
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1996: Martin S J; Amarante-Mendes G P; Shi L; Chuang T H; Casiano C A; O'Brien G A; Fitzgerald P; Tan E M; Bokoch G M; Greenberg A H; Green D R
The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.
The EMBO journal 1996;15(10):2407-16.
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1996: Green D R; McGahon A; Martin S J
Regulation of apoptosis by oncogenes.
Journal of cellular biochemistry 1996;60(1):33-8.
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1996: Martin S J; Amarante-Mendes G P; Green D R
Cytotoxic lymphocyte killing enters the ice age.
Advances in experimental medicine and biology 1996;406():29-37.
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1995: Martin S J; Reutelingsperger C P; McGahon A J; Rader J A; van Schie R C; LaFace D M; Green D R
Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.
The Journal of experimental medicine 1995;182(5):1545-56.
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1995: Martin S J; Newmeyer D D; Mathias S; Farschon D M; Wang H G; Reed J C; Kolesnick R N; Green D R
Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.
The EMBO journal 1995;14(21):5191-200.
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1995: Martin S J; Takayama S; McGahon A J; Miyashita T; Corbeil J; Kolesnick R N; Reed J C; Green D R
Inhibition of ceramide-induced apoptosis by Bcl-2.
Cell death and differentiation 1995;2(4):253-7.
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1995: Green D R; Martin S J
The killer and the executioner: how apoptosis controls malignancy.
Current opinion in immunology 1995;7(5):694-703.
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1995: Vyakarnam A; Matear P M; Martin S J; Wagstaff M
Th1 cells specific for HIV-1 gag p24 are less efficient than Th0 cells in supporting HIV replication, and inhibit virus replication in Th0 cells.
Immunology 1995;86(1):85-96.
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1995: McGahon A J; Nishioka W K; Martin S J; Mahboubi A; Cotter T G; Green D R
Regulation of the Fas apoptotic cell death pathway by Abl.
The Journal of biological chemistry 1995;270(38):22625-31.
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1995: Martin S J; Green D R
Protease activation during apoptosis: death by a thousand cuts?
Cell 1995;82(3):349-52.
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1995: Martin S J; McGahon A J; Nishioka W K; LaFace D; Guo X; Th'ng J; Bradbury E M; Green D R
p34cdc2 and apoptosis.
Science (New York, N.Y.) 1995;269(5220):106-7.
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1995: Gulbins E; Bissonnette R; Mahboubi A; Martin S; Nishioka W; Brunner T; Baier G; Baier-Bitterlich G; Byrd C; Lang F
FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway.
Immunity 1995;2(4):341-51.
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1995: Martin S J; O'Brien G A; Nishioka W K; McGahon A J; Mahboubi A; Saido T C; Green D R
Proteolysis of fodrin (non-erythroid spectrin) during apoptosis.
The Journal of biological chemistry 1995;270(12):6425-8.
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1995: Martin S J; Green D R
Apoptosis and cancer: the failure of controls on cell death and cell survival.
Critical reviews in oncology/hematology 1995;18(2):137-53.
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1995: Brunner T; Mogil R J; LaFace D; Yoo N J; Mahboubi A; Echeverri F; Martin S J; Force W R; Lynch D H; Ware C F
Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.
Nature 1995;373(6513):441-4.
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1995: Martin S J; Green D R
Apoptosis during HIV infection. A cytopathic effect of HIV or an important host-defense mechanism against viruses in general?
Advances in experimental medicine and biology 1995;374():129-38.
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1995: McGahon A J; Martin S J; Bissonnette R P; Mahboubi A; Shi Y; Mogil R J; Nishioka W K; Green D R
The end of the (cell) line: methods for the study of apoptosis in vitro.
Methods in cell biology 1995;46():153-85.
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1994: Martin S J; Green D R
Apoptosis as a goal of cancer therapy.
Current opinion in oncology 1994;6(6):616-21.
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1994: Martin S J; Green D R; Cotter T G
Dicing with death: dissecting the components of the apoptosis machinery.
Trends in biochemical sciences 1994;19(1):26-30.
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1994: Martin S J; Matear P M; Vyakarnam A
HIV-1 infection of human CD4+ T cells in vitro. Differential induction of apoptosis in these cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(1):330-42.
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1993: Martin S J; Vyakarnam A; Cheingsong-Popov R; Callow D; Jones K L; Senior J M; Adams S E; Kingsman A J; Matear P; Gotch F M
Immunization of human HIV-seronegative volunteers with recombinant p17/p24:Ty virus-like particles elicits HIV-1 p24-specific cellular and humoral immune responses.
AIDS (London, England) 1993;7(10):1315-23.
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1991: Martin S J; Cotter T G
Ultraviolet B irradiation of human leukaemia HL-60 cells in vitro induces apoptosis.
International journal of radiation biology 1991;59(4):1001-16.
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1991: Lennon S V; Martin S J; Cotter T G
Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli.
Cell proliferation 1991;24(2):203-14.
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1991: Martin S J; Mazdai G; Strain J J; Cotter T G; Hannigan B M
Programmed cell death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency.
Clinical and experimental immunology 1991;83(2):338-43.
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1990: Martin S J; Cotter T G
Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL-60 cells.
Cell and tissue kinetics 1990;23(6):545-59.
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1990: Cotter T G; Lennon S V; Glynn J G; Martin S J
Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells.
Anticancer research 1990;10(5A):1153-9.
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1990: Martin S J; Lennon S V; Bonham A M; Cotter T G
Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1859-67.
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1990: Martin S J; Bonham A M; Cotter T G
The involvement of RNA and protein synthesis in programmed cell death (apoptosis) in human leukaemia HL-60 cells.
Biochemical Society transactions 1990;18(4):634-6.
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1990: Lennon S V; Martin S J; Cotter T G
Induction of apoptosis (programmed cell death) in tumour cell lines by widely diverging stimuli.
Biochemical Society transactions 1990;18(2):343-5.
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1990: Martin S J; Cotter T G
Specific loss of microtubules in HL-60 cells leads to programmed cell death (apoptosis).
Biochemical Society transactions 1990;18(2):299-301.
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1990: Martin S J; Bradley J G; Cotter T G
HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis.
Clinical and experimental immunology 1990;79(3):448-53.
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