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John Babich

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Chemicals & Drugs

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TOP 3
Genliang Lu; Kevin P Maresca; Craig N Zimmerman; William C Eckelman; Shawn M Hillier; John L Joyal; John Babich
Synthesis and SAR of ⁹⁹mTc/Re-labeled small molecule prostate specific membrane antigen inhibitors with novel polar chelates.
Genliang Lu; Kevin P Maresca; Craig N Zimmerman; William Eckelman; Shawn M Hillier; John L Joyal; John Babich
Synthesis and SAR of novel Re/99mTc-labeled benzenesulfonamide carbonic anhydrase IX inhibitors for molecular imaging of tumor hypoxia.
Mark D Bartholomä; Anthony R Vortherms; Shawn Hillier; John Joyal; John Babich; Robert P Doyle; Jon Zubieta
Synthesis, cytotoxicity and cellular uptake studies of N3 functionalized Re(CO)3 thymidine complexes.

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All Publications

2013: Genliang Lu; Kevin P Maresca; Craig N Zimmerman; William C Eckelman; Shawn M Hillier; John L Joyal; John Babich
Synthesis and SAR of ⁹⁹mTc/Re-labeled small molecule prostate specific membrane antigen inhibitors with novel polar chelates.
Bioorganic & medicinal chemistry letters 2013;23(5):1557-63.
2013: Genliang Lu; Kevin P Maresca; Craig N Zimmerman; William Eckelman; Shawn M Hillier; John L Joyal; John Babich
Synthesis and SAR of novel Re/99mTc-labeled benzenesulfonamide carbonic anhydrase IX inhibitors for molecular imaging of tumor hypoxia.
Journal of medicinal chemistry 2013;56(2):510-20.
2011: Mark D Bartholomä; Anthony R Vortherms; Shawn Hillier; John Joyal; John Babich; Robert P Doyle; Jon Zubieta
Synthesis, cytotoxicity and cellular uptake studies of N3 functionalized Re(CO)3 thymidine complexes.
Dalton transactions (Cambridge, England : 2003) 2011;40(23):6216-25.
2010: Mark D Bartholomä; Anthony R Vortherms; Shawn Hillier; Birgit Ploier; John Joyal; John Babich; Robert P Doyle; Jon Zubieta
Synthesis, cytotoxicity, and insight into the mode of action of Re(CO)3 thymidine complexes.
ChemMedChem 2010;5(9):1513-29.
2010: John L Joyal; John A Barrett; John C Marquis; Jianqing Chen; Shawn M Hillier; Kevin P Maresca; Marie Boyd; Kenneth Gage; Sridhar Nimmagadda ; James F Kronauge; Matthias Friebe; Ludger Dinkelborg; James B Stubbs; Michael G Stabin; Rob Mairs; Martin G Pomper; John Babich
Preclinical evaluation of an 131I-labeled benzamide for targeted radiotherapy of metastatic melanoma.
Cancer research 2010;70(10):4045-53.
2010: Chitra Sundararajan; Travis R Besanger; Renée Labiris; Katharina J Guenther; Thomas Strack; Robert Garafalo; Thomas T Kawabata; Deborah Finco-Kent; Jon Zubieta; John Babich; John F Valliant
Synthesis and characterization of rhenium and technetium-99m labeled insulin.
Journal of medicinal chemistry 2010;53(6):2612-21.
2009: Mark Bartholomä; John F Valliant; Kevin P Maresca; John Babich; Jon Zubieta
Single amino acid chelates (SAAC): a strategy for the design of technetium and rhenium radiopharmaceuticals.
Chemical communications (Cambridge, England) 2009;(5):493-512.
2009: K P Maresca; S M Hillier; F J Femia; D Keith; C Barone; J L Joyal; C N Zimmerman; Alan P Kozikowski; J A Barrett; William Eckelman; John Babich
A series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA) as radiolabeled probes for targeting prostate cancer.
Journal of medicinal chemistry 2009;52(2):347-57.
2008: Ying Chen; Catherine A Foss; Youngjoo Byun; Sridhar Nimmagadda ; Mrudula Pullambhatla; James J Fox; Mark Castanares; Shawn E Lupold; John Babich; RONNIE MEASE; Martin G Pomper
Radiohalogenated prostate-specific membrane antigen (PSMA)-based ureas as imaging agents for prostate cancer.
Journal of medicinal chemistry 2008;51(24):7933-43.
2008: Andrea F Armstrong; Nick Oakley; Shannon Parker; Patrick W Causey; Jennifer Lemon; Alfredo Capretta; Craig Zimmerman; John Joyal; Francis Appoh; Jon Zubieta; John Babich; Gurmit Singh; John F Valliant
A robust strategy for the preparation of libraries of metallopeptides. A new paradigm for the discovery of targeted molecular imaging and therapy agents.
Chemical communications (Cambridge, England) 2008;(43):5532-4.
2008: Anthony G McCluskey; Marie Boyd; S L Pimlott; John Babich; Mark Gaze; Robert J Mairs
Experimental treatment of neuroblastoma using [131I]meta-iodobenzylguanidine and topotecan in combination.
The British journal of radiology 2008;81 Spec No 1():S28-35.
2008: Frank J Femia; Kevin P Maresca; Shawn M Hillier; Craig N Zimmerman; John L Joyal; John A Barrett; Aras Omer; Vasken Dilsizian; William Eckelman; John Babich
Synthesis and evaluation of a series of 99mTc(CO)3+ lisinopril complexes for in vivo imaging of angiotensin-converting enzyme expression.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(6):970-7.
2008: Karin A Stephenson; Leslie C Reid; Jon Zubieta; John Babich; Mei-Ping Kung; Hank F Kung; John F Valliant
Synthesis and screening of a library of Re/Tc-based amyloid probes derived from beta-breaker peptides.
Bioconjugate chemistry 2008;19(5):1087-94.
2008: Paul Schaffer; Jacqueline A Gleave; Jennifer A Lemon; Leslie C Reid; Laura K K Pacey; Troy H Farncombe; Douglas R Boreham; Jon Zubieta; John Babich; Laurie C Doering; John F Valliant
Isostructural fluorescent and radioactive probes for monitoring neural stem and progenitor cell transplants.
Nuclear medicine and biology 2008;35(2):159-69.
2007: Ganesan Vaidyanathan; Donna J Affleck; Kevin L Alston; Xiao-Guang Zhao; Marc Hens; Duncan H Hunter; John Babich; Michael R Zalutsky
A kit method for the high level synthesis of [211At]MABG.
Bioorganic & medicinal chemistry 2007;15(10):3430-6.
2007: Christopher J Pastore; John Babich; James E Udelson
Future directions of myocardial fatty acid imaging.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2007;14(3 Suppl):S153-63.
2007: William Eckelman; John Babich
Synthesis and validation of fatty acid analogs radiolabeled by nonisotopic substitution.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2007;14(3 Suppl):S100-9.
2006: Shelly James; Kevin P Maresca; John Babich; John F Valliant; Laurie Doering; Jon Zubieta
Isostructural Re and 99mTc complexes of biotin derivatives for fluorescence and radioimaging studies.
Bioconjugate chemistry 2006;17(3):590-6.
2006: Shelly James; Kevin P Maresca; Damian G Allis; John F Valliant; William Eckelman; John Babich; Jon Zubieta
Extension of the single amino acid chelate concept (SAAC) to bifunctional biotin analogues for complexation of the M(CO)3(+1) Core (M = Tc and Re): syntheses, characterization, biotinidase stability, and avidin binding.
Bioconjugate chemistry 2006;17(3):579-89.
2006: Lihui Wei; John Babich; Wayne Ouellette; Jon Zubieta
Developing the {M(CO)3}+ core for fluorescence applications: Rhenium tricarbonyl core complexes with benzimidazole, quinoline, and tryptophan derivatives.
Inorganic chemistry 2006;45(7):3057-66.
2006: Amanda Donovan; Jane Forbes; Peter Dorff; Paul Schaffer; John Babich; John F Valliant
A new strategy for preparing molecular imaging and therapy agents using fluorine-rich (fluorous) soluble supports.
Journal of the American Chemical Society 2006;128(11):3536-7.
2005: SANGEETA RAY; Paul Schaffer; John Babich; John F Valliant; Jon Zubieta
Design and synthesis of site directed maleimide bifunctional chelators for technetium and rhenium.
Dalton transactions (Cambridge, England : 2003) 2005;(24):3886-97.
2005: Natasha E Fullerton; Marie Boyd; Susan C Ross; Sally L Pimlott; John Babich; David Kirk; Michael R Zalutsky; Robert J Mairs
Comparison of radiohaloanalogues of meta-iodobenzylguanidine (MIBG) for a combined gene- and targeted radiotherapy approach to bladder carcinoma.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2005;1(6):611-8.
2005: Vasken Dilsizian; Timothy M Bateman; Steven Bergmann; Roger Des Prez; Martin Y Magram; Anne E Goodbody; John Babich; James E Udelson
Metabolic imaging with beta-methyl-p-[(123)I]-iodophenyl-pentadecanoic acid identifies ischemic memory after demand ischemia.
Circulation 2005;112(14):2169-74.
2005: Neva Lazarova; John Babich; John F Valliant; Paul Schaffer; Shelly James; Jon Zubieta
Thiol- and thioether-based bifunctional chelates for the {M(CO)3}+ core (M = Tc, Re).
Inorganic chemistry 2005;44(19):6763-70.
2005: Karin A Stephenson; SANGEETA RAY; Oyebola O Sogbein; Murali K Levadala; Nicole McFarlane; Douglas R Boreham; Kevin P Maresca; John Babich; Jon Zubieta; John F Valliant
A new strategy for the preparation of peptide-targeted technetium and rhenium radiopharmaceuticals. The automated solid-phase synthesis, characterization, labeling, and screening of a peptide-ligand library targeted at the formyl peptide receptor.
Bioconjugate chemistry 2005;16(5):1189-95.
2005: SANGEETA RAY; Kevin P Maresca; Karin A Stephenson; John F Valliant; John Babich; Wendy A Graham; Marlene Barzana; Qing Dong; Alan J Fischman; Jon Zubieta
N,N-bis(2-mercaptoethyl)methylamine: a new coligand for Tc-99m labeling of hydrazinonicotinamide peptides.
Bioconjugate chemistry 2005;16(4):885-902.
2005: SANGEETA RAY; John Babich; Jon Zubieta
Site directed maleimide bifunctional chelators for the M(CO)3+ core (M =(99m)Tc, Re).
Chemical communications (Cambridge, England) 2005;(13):1784-6.
2005: Lihui Wei; John Babich; William Eckelman; Jon Zubieta
Rhenium tricarbonyl core complexes of thymidine and uridine derivatives.
Inorganic chemistry 2005;44(7):2198-209.
2005: SANGEETA RAY; Kevin P Maresca; Lynn Francesconi; John F Valliant; John Babich; Jon Zubieta
New directions in the coordination chemistry of 99mTc: a reflection on technetium core structures and a strategy for new chelate design.
Nuclear medicine and biology 2005;32(1):1-20.
2004: Lihui Wei; John Babich; Jon Zubieta
Unusual reactivity of the [Re(V)O]3+ core: syntheses and characterization of novel rhenium halide complexes with n-methyl-o-diaminobenzene.
Inorganic chemistry 2004;43(20):6445-54.
2004: Karin A Stephenson; SANGEETA RAY; Travis R Besanger; Oyebola O Sogbein; Murali K Levadala; Nicole McFarlane; Jennifer A Lemon; Douglas R Boreham; Kevin P Maresca; John D Brennan; John Babich; Jon Zubieta; John F Valliant
Bridging the gap between in vitro and in vivo imaging: isostructural Re and 99mTc complexes for correlating fluorescence and radioimaging studies.
Journal of the American Chemical Society 2004;126(28):8598-9.
2004: Karin A Stephenson; Jon Zubieta; SANGEETA RAY; Murali K Levadala; Linda Taggart; Lorna Ryan; Nicole McFarlane; Douglas R Boreham; Kevin P Maresca; John Babich; John F Valliant
A new strategy for the preparation of peptide-targeted radiopharmaceuticals based on an fmoc-lysine-derived single amino acid chelate (SAAC). automated solid-phase synthesis, NMR characterization, and in vitro screening of fMLF(SAAC)G and fMLF[(SAAC-Re(CO)3)+]G.
Bioconjugate chemistry 2004;15(1):128-36.
2002: SANGEETA RAY; Murali K Levadala; Neva Lazarova; Lihui Wei; John F Valliant; Karin A Stephenson; John Babich; Kevin P Maresca; Jon Zubieta
Bifunctional single amino acid chelates for labeling of biomolecules with the [Tc(CO)(3)](+) and [Re(CO)(3)](+) cores. Crystal and molecular structures of [ReBr(CO)(3)(H(2)NCH(2)C(5)H(4)N)], [Re(CO)(3)[(C(5)H(4)NCH(2))(2)NH]]Br, [Re(CO)(3)[(C(5)H(4)NCH(2))(2)NCH(2)CO(2)H]]Br, [Re(CO)(3)[X(Y)NCH(2)CO(2)CH(2)CH(3)]]Br (X = Y = 2-pyridylmethyl; X = 2-pyridylmethyl, Y = 2-(1-methylimidazolyl)methyl; X = Y = 2-(1-methylimidazolyl)methyl), [ReBr(CO)(3)[(C(5)H(4)NCH(2))NH(CH(2)C(4)H(3)S)]], and [Re(CO)(3)[(C(5)H(4)NCH(2))N(CH(2)C(4)H(3)S)(CH(2)CO(2))]].
Inorganic chemistry 2002;41(24):6417-25.
2002: SANGEETA RAY; Lihui Wei; Murali K Levadala; Neva Lazarova; Vladimir Golub; Charles J O'Connor; Karin A Stephenson; John F Valliant; John Babich; Jon Zubieta
[Re(III)Cl(3)] core complexes with bifunctional single amino acid chelates.
Inorganic chemistry 2002;41(22):5795-802.
2001: X Chen; F J Femia; John Babich; J A Zubieta
Rhenium(I) carbonyl complexes of 2,4,6-tris(2-pyridyl)-1,3,5-triazine (TPT). Rhenium(I)-promoted methoxylation of the triazine ring carbon atom in dinuclear rhenium complexes.
Inorganic chemistry 2001;40(12):2769-77.
1999: Alexander Hoepping; John Babich; J A Zubieta; Kenneth M Johnson; S Machill; Alan P Kozikowski
Synthesis and biological evaluation of two novel DAT-binding technetium complexes containing a piperidine based analogue of cocaine.
Bioorganic & medicinal chemistry letters 1999;9(22):3211-6.
1996: E A Carter; R G Tompkins; John Babich; J Correia; E M Bailey; A J Fischman
Thermal injury in rats alters glucose utilization by skin, wound, and small intestine, but not by skeletal muscle.
Metabolism: clinical and experimental 1996;45(9):1161-7.
1994: H Young; Paul Carnochan; J Zweit; John Babich; Simon R Cherry; R Ott
Tissue blood flow estimation with copper(II)-pyruvaldehyde bis (N-4-methylthiosemicarbazone) and PET.
Journal of nuclear biology and medicine (Turin, Italy : 1991) 1994;38(4 Suppl 1):89-91.
1994: H Young; Paul Carnochan; J Zweit; John Babich; Simon R Cherry; R Ott
Evaluation of copper(II)-pyruvaldehyde bis (N-4-methylthiosemicarbazone) for tissue blood flow measurement using a trapped tracer model.
European journal of nuclear medicine 1994;21(4):336-41.
1992: M A Bakir; S Eccles; John Babich; N Aftab; J Styles; C J Dean; R M Lambrecht; Robert J Ott; S A Eccles; J M Styles
c-erbB2 protein overexpression in breast cancer as a target for PET using iodine-124-labeled monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(12):2154-60.
1992: Robert J Ott; D Tait; Maggie A Flower; John Babich; R M Lambrecht
Treatment planning for 131I-mIBG radiotherapy of neural crest tumours using 124I-mIBG positron emission tomography.
The British journal of radiology 1992;65(777):787-91.
1992: Brian R Davidson; H Young; W A Waddington; John Babich; G A Clarke; M D Short; Paul B Boulos; J Styles; C Dean; Peter J Ell
Preoperative imaging of colorectal cancers. Targeting the epithelial membrane antigen with a radiation-labeled monoclonal antibody.
Cancer 1992;69(3):620-5.
1992: J Zweit; R Goodall; M Cox; John Babich; G A Potter; Harbans L Sharma; Robert J Ott
Development of a high performance zinc-62/copper-62 radionuclide generator for positron emission tomography.
European journal of nuclear medicine 1992;19(6):418-25.
1991: Brian R Davidson; John Babich; H Young; W Waddington; G Clarke; M Short; Paul B Boulos; J Styles; C Dean
The effect of circulating antigen and radiolabel stability on the biodistribution of an indium labelled antibody.
British journal of cancer 1991;64(5):850-6.
1991: John Babich
Technetium-99m-HMPAO retention and the role of glutathione: the debate continues.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1991;32(9):1681-3.
1991: Joseph A O'Donoghue; TE Wheldon; John Babich; J S Moyes; A Barrett; S T Meller
Implications of the uptake of 131I-radiolabelled meta-iodobenzylguanidine (mIBG) for the targeted radiotherapy of neuroblastoma.
The British journal of radiology 1991;64(761):428-34.
1991: Robert J Mairs; Wilson J Angerson; Mark Gaze; T Murray; John Babich; R Reid; C McSharry
The distribution of alternative agents for targeted radiotherapy within human neuroblastoma spheroids.
British journal of cancer 1991;63(3):404-9.
1991: Robert J Mairs; Wilson J Angerson; John Babich; T Murray
Differential penetration of targeting agents into multicellular spheroids derived from human neuroblastoma.
Progress in clinical and biological research 1991;366():495-501.
1991: Joseph A O'Donoghue; TE Wheldon; John Babich; J S Moyes; A Barrett; S T Meller
Therapeutic implications of the uptake of radiolabelled mIBG for the treatment of neuroblastoma.
Progress in clinical and biological research 1991;366():455-61.
1991: Robert J Ott; M Brada; Maggie A Flower; John Babich; Simon R Cherry; B J Deehan
Measurements of blood-brain barrier permeability in patients undergoing radiotherapy and chemotherapy for primary cerebral lymphoma.
European journal of cancer (Oxford, England : 1990) 1991;27(11):1356-61.
1990: Simon R Cherry; Paul Carnochan; John Babich; F Serafini; N P Rowell; I A Watson
Quantitative in vivo measurements of tumor perfusion using rubidium-81 and positron emission tomography.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(8):1307-15.
1990: A T Irvine; Maggie A Flower; Robert J Ott; John Babich; F Kabir; V Ralph McCready
An evaluation of 99mTc-HMPAO uptake in cerebral gliomas--a comparison with X-ray CT.
European journal of nuclear medicine 1990;16(4-6):293-8.
1989: V R McCready; R J Ott; John Babich
The future of PET.
Nuclear medicine communications 1989;10(9):621-5.
1989: J S Moyes; John Babich; R Carter; S T Meller; M Agrawal; T J McElwain
Quantitative study of radioiodinated metaiodobenzylguanidine uptake in children with neuroblastoma: correlation with tumor histopathology.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1989;30(4):474-80.
1989: Simon R Cherry; Paul K Marsden; Robert J Ott; Maggie A Flower; S Webb; John Babich
Image quantification with a large area multiwire proportional chamber positron camera (MUP-PET).
European journal of nuclear medicine 1989;15(11):694-700.
1988: J L Lacy; M E Ball; Mario S Verani; Henry B Wiles; John Babich; A D LeBlanc; M Stabin; L Bolomey; Robert Roberts
An improved tungsten-178/tantalum-178 generator system for high volume clinical applications.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1988;29(9):1526-38.
1988: Linda S Lashford; J Moyes; R Ott; S Fielding; John Babich; S Mellors; Isky Gordon; K Evans; JT Kemshead
The biodistribution and pharmacokinetics of meta-iodobenzylguanidine in childhood neuroblastoma.
European journal of nuclear medicine 1988;13(11):574-7.
1988: John Babich; F Keeling; Maggie A Flower; L Repetto; A Whitton; S Fielding; A Fullbrook; Robert J Ott; V Ralph McCready
Initial experience with Tc-99m-HM-PAO in the study of brain tumors.
European journal of nuclear medicine 1988;14(1):39-44.
1987: mark vincent; John Babich; A Irvine; V R McCready; I E Smith
Failure of iodine-131 MIBG imaging in small cell lung carcinoma.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1987;28(7):1230.
1987: P A Hammersley; V R McCready; John Babich; G Coghlan
99mTc-HMPAO as a tumour blood flow agent.
European journal of nuclear medicine 1987;13(2):90-4.
1986: M C Ward; K R Roberts; John Babich; M A Bukhari; G Coghlan; J H Westwood; V R McCready; Robert J Ott
An antibody-desferrioxamine conjugate labelled with 67Ga.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1986;13(5):505-7.
1984: J L Lacy; A D LeBlanc; John Babich; Michael W. Bungo; L A Latson; R M Lewis; L R Poliner; R H Jones; P C Johnson
A gamma camera for medical applications, using a multiwire proportional counter.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1984;25(9):1003-12.