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Lars Knutsen

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Roger J Gillespie; David R Adams; David Bebbington; Karen Benwell; Ian A Cliffe; Claire E Dawson; Colin T Dourish; Allan Fletcher; Suneel Gaur; Paul R Giles; Allan M Jordan; Antony Knight; Lars Knutsen; Anthony Lawrence; Joanne Lerpiniere; Anil Misra; Richard H P Porter; Robert M Pratt; Robin Shepherd; Rebecca Upton; Simon E Ward; Scott M Weiss; Douglas S Williamson
Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.
Michael J Marino; Lars Knutsen; Michael Williams
Emerging opportunities for antipsychotic drug discovery in the postgenomic era.
Lars Knutsen; Christopher J Hobbs; Christopher G Earnshaw; Andrea Fiumana; Jenny Gilbert; Sarah L Mellor; Fleur Radford; Nichola J Smith; Philip J Birch; J Russell Burley; Stuart D C Ward; Iain F James
Synthesis and SAR of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers.

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2008: Roger J Gillespie; David R Adams; David Bebbington; Karen Benwell; Ian A Cliffe; Claire E Dawson; Colin T Dourish; Allan Fletcher; Suneel Gaur; Paul R Giles; Allan M Jordan; Antony Knight; Lars Knutsen; Anthony Lawrence; Joanne Lerpiniere; Anil Misra; Richard H P Porter; Robert M Pratt; Robin Shepherd; Rebecca Upton; Simon E Ward; Scott M Weiss; Douglas S Williamson
Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.
Bioorganic & medicinal chemistry letters 2008;18(9):2916-9.
2008: Michael J Marino; Lars Knutsen; Michael Williams
Emerging opportunities for antipsychotic drug discovery in the postgenomic era.
Journal of medicinal chemistry 2008;51(5):1077-107.
2007: Lars Knutsen; Christopher J Hobbs; Christopher G Earnshaw; Andrea Fiumana; Jenny Gilbert; Sarah L Mellor; Fleur Radford; Nichola J Smith; Philip J Birch; J Russell Burley; Stuart D C Ward; Iain F James
Synthesis and SAR of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers.
Bioorganic & medicinal chemistry letters 2007;17(3):662-7.
2005: Margaret Haldeman; Barbara Vieira; Fred Winer; Lars Knutsen
Exploration tools for drug discovery and beyond: applying SciFinder to interdisciplinary research.
Current drug discovery technologies 2005;2(2):69-74.
2001: Lars Knutsen; S M Weiss
KW-6002 (Kyowa Hakko Kogyo).
Current opinion in investigational drugs (London, England : 2000) 2001;2(5):668-73.
2000: J Bently; Ian A Cliffe; Lars Knutsen; N J T Monck
Medicinal chemistry--16th international symposium. 18-22 September 2000, Bologna, Italy.
IDrugs : the investigational drugs journal 2000;3(12):1457-86.
1999: Ian A Cliffe; David Bebbington; Roger J Gillespie; Lars Knutsen
RSC-SCI--tenth medicinal chemistry symposium. 5-8 September 1999, Churchill College, Cambridge, UK.
IDrugs : the investigational drugs journal 1999;2(11):1122-5.
1999: KE Andersen; J L Sørensen; PO Huusfeldt; Lars Knutsen; J Lau; BF Lundt; H Petersen; PD Suzdak; MD Swedberg
Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates.
Journal of medicinal chemistry 1999;42(21):4281-91.
1999: Lars Knutsen; J Lau; H Petersen; C Thomsen; J U Weis; M Shalmi; Martin Judge; A J Hansen; MJ Sheardown
N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects.
Journal of medicinal chemistry 1999;42(18):3463-77.
1999: Lars Knutsen; KE Andersen; J Lau; BF Lundt; R F Henry; H E Morton; L Naerum; H Petersen; H Stephensen; PD Suzdak; MD Swedberg; C Thomsen; P O Sørensen
Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.
Journal of medicinal chemistry 1999;42(18):3447-62.
1998: J P Mogensen; S M Roberts; A N Bowler; C Thomsen; Lars Knutsen
The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles.
Bioorganic & medicinal chemistry letters 1998;8(13):1767-70.
1993: H Klitgaard; Lars Knutsen; C Thomsen
Contrasting effects of adenosine A1 and A2 receptor ligands in different chemoconvulsive rodent models.
European journal of pharmacology 1993;242(3):221-8.
1993: KE Andersen; C Braestrup; F C Grønwald; A S Jørgensen; E B Nielsen; U Sonnewald; P O Sørensen; PD Suzdak; Lars Knutsen
The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.
Journal of medicinal chemistry 1993;36(12):1716-25.
1992: PD Suzdak; K Frederiksen; KE Andersen; P O Sørensen; Lars Knutsen; E B Nielsen
NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization.
European journal of pharmacology 1992;224(2-3):189-98.
1992: PD Suzdak; MD Swedberg; KE Andersen; Lars Knutsen; C Braestrup
In vivo labeling of the central GABA uptake carrier with 3H-Tiagabine.
Life sciences 1992;51(24):1857-68.
1991: E B Nielsen; PD Suzdak; KE Andersen; Lars Knutsen; U Sonnewald; C Braestrup
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.
European journal of pharmacology 1991;196(3):257-66.
1990: C Braestrup; E B Nielsen; U Sonnewald; Lars Knutsen; KE Andersen; J A Jansen; K Frederiksen; P H Andersen; A Mortensen; PD Suzdak
(R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier.
Journal of neurochemistry 1990;54(2):639-47.
1986: W L Mitchell; P Ravenscroft; M L Hill; Lars Knutsen; B D Judkins; R F Newton; D I Scopes
Synthesis and antiviral properties of 5-(2-substituted vinyl)-6-aza-2'-deoxyuridines.
Journal of medicinal chemistry 1986;29(5):809-16.