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Lubbert Dijkhuizen

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Hans Leemhuis; Tjaard Pijning; Sander S van Leeuwen; Bauke W Dijkstra; Justyna Malgorzata Dobruchowska; Slavko Kralj; Lubbert Dijkhuizen
Glucansucrases: three-dimensional structures, reactions, mechanism, α-glucan analysis and their implications in biotechnology and food applications.
Bo Li; Lubbert Dijkhuizen; Justyna Malgorzata Dobruchowska; Gerrit J Gerwig; Johannis P Kamerling
Structural investigation of water-soluble polysaccharides extracted from the fruit bodies of Coprinus comatus.
Hans Leemhuis; Tjaard Pijning; Willem P Dijkman; Justyna Malgorzata Dobruchowska; Pieter Grijpstra; Johannis P Kamerling; Slavko Kralj; Lubbert Dijkhuizen
4,6-α-Glucanotransferase activity occurs more widespread in Lactobacillus strains and constitutes a separate GH70 subfamily.

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2013: Hans Leemhuis; Tjaard Pijning; Sander S van Leeuwen; Bauke W Dijkstra; Justyna Malgorzata Dobruchowska; Slavko Kralj; Lubbert Dijkhuizen
Glucansucrases: three-dimensional structures, reactions, mechanism, α-glucan analysis and their implications in biotechnology and food applications.
Journal of biotechnology 2013;163(2):250-72.
2013: Bo Li; Lubbert Dijkhuizen; Justyna Malgorzata Dobruchowska; Gerrit J Gerwig; Johannis P Kamerling
Structural investigation of water-soluble polysaccharides extracted from the fruit bodies of Coprinus comatus.
Carbohydrate polymers 2013;91(1):314-21.
2013: Hans Leemhuis; Tjaard Pijning; Willem P Dijkman; Justyna Malgorzata Dobruchowska; Pieter Grijpstra; Johannis P Kamerling; Slavko Kralj; Lubbert Dijkhuizen
4,6-α-Glucanotransferase activity occurs more widespread in Lactobacillus strains and constitutes a separate GH70 subfamily.
Applied microbiology and biotechnology 2013;97(1):181-93.
2012: Sander S van Leeuwen; Johannis P Kamerling; Ruud J W Schoemaker; Christel J A M Timmer; Lubbert Dijkhuizen
N- and o-glycosylation of a commercial bovine whey protein product.
Journal of agricultural and food chemistry 2012;60(51):12553-64.
2012: Tjaard Pijning; Andreja Vujičić-Žagar; Lubbert Dijkhuizen; Slavko Kralj; Bauke W Dijkstra
Structure of the α-1,6/α-1,4-specific glucansucrase GTFA from Lactobacillus reuteri 121.
Acta crystallographica. Section F, Structural biology and crystallization communications 2012;68(Pt 12):1448-54.
2012: Maarten Hotse Wilbrink; Robert van der Geize; Lubbert Dijkhuizen
Molecular characterization of ltp3 and ltp4, essential for C24-branched chain sterol-side-chain degradation in Rhodococcus rhodochrous DSM 43269.
Microbiology (Reading, England) 2012;158(Pt 12):3054-62.
2012: Munir A Anwar; Bauke W Dijkstra; Slavko Kralj; Hans Leemhuis; Tjaard Pijning; Lubbert Dijkhuizen
The role of conserved inulosucrase residues in the reaction and product specificity of Lactobacillus reuteri inulosucrase.
The FEBS journal 2012;279(19):3612-21.
2012: Niels van Oosterwijk; Lubbert Dijkhuizen; Jan Knol; Robert van der Geize; Bauke W Dijkstra
Structure and catalytic mechanism of 3-ketosteroid-Delta4-(5α)-dehydrogenase from Rhodococcus jostii RHA1 genome.
The Journal of biological chemistry 2012;287(37):30975-83.
2012: Sander S van Leeuwen; Johannis P Kamerling; Ruud J W Schoemaker; Christel J A M Timmer; Lubbert Dijkhuizen
Use of Wisteria floribunda agglutinin affinity chromatography in the structural analysis of the bovine lactoferrin N-linked glycosylation.
Biochimica et biophysica acta 2012;1820(9):1444-55.
2012: Timothy Desmet; Lubbert Dijkhuizen; Vanessa Eastwick-Field; Vladimir Křen; Pavla Bojarová; Wim Soetaert; Alexander Schiller
Enzymatic glycosylation of small molecules: challenging substrates require tailored catalysts.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(35):10786-801.
2012: Jolanda M van Munster; Lubbert Dijkhuizen; Rachel M van der Kaaij; M J E C van der Maarel
Biochemical characterization of Aspergillus niger CfcI, a glycoside hydrolase family 18 chitinase that releases monomers during substrate hydrolysis.
Microbiology (Reading, England) 2012;158(Pt 8):2168-79.
2012: Wouter de Jong; Lubbert Dijkhuizen; Erik Vijgenboom; Han A B Wösten; Dennis Claessen
SapB and the rodlins are required for development of Streptomyces coelicolor in high osmolarity media.
FEMS microbiology letters 2012;329(2):154-9.
2012: Justyna Malgorzata Dobruchowska; Gerrit J Gerwig; Pieter Grijpstra; Slavko Kralj; Hans Leemhuis; Lubbert Dijkhuizen; Johannis P Kamerling
Structural characterization of linear isomalto-/malto-oligomer products synthesized by the novel GTFB 4,6-α-glucanotransferase enzyme from Lactobacillus reuteri 121.
Glycobiology 2012;22(4):517-28.
2011: Slavko Kralj; Hans Leemhuis; Amarila Malik; Ariyanti Oetari; Rachel M van der Kaaij; Sander S van Leeuwen; Justyna Malgorzata Dobruchowska; Pieter Grijpstra; Johannis P Kamerling; Lubbert Dijkhuizen
4,6-α-glucanotransferase, a novel enzyme that structurally and functionally provides an evolutionary link between glycoside hydrolase enzyme families 13 and 70.
Applied and environmental microbiology 2011;77(22):8154-63.
2011: Niels van Oosterwijk; Lubbert Dijkhuizen; Jan Knol; Robert van der Geize; Bauke W Dijkstra
Cloning, overexpression, purification, crystallization and preliminary X-ray analysis of 3-ketosteroid Δ(4)-(5α)-dehydrogenase from Rhodococcus jostii RHA1.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 10):1269-73.
2011: Tjaard Pijning; Justyna Malgorzata Dobruchowska; Slavko Kralj; Hans Leemhuis; Munir A Anwar; Markus Böger; Lubbert Dijkhuizen; Bauke W Dijkstra
Crystal structure of inulosucrase from Lactobacillus: insights into the substrate specificity and product specificity of GH68 fructansucrases.
Journal of molecular biology 2011;412(1):80-93.
2011: Robert van der Geize; A W F Grommen; Gerda I Hessels; A A C Jacobs; Lubbert Dijkhuizen
The steroid catabolic pathway of the intracellular pathogen Rhodococcus equi is important for pathogenesis and a target for vaccine development.
PLoS pathogens 2011;7(8):e1002181.
2011: M H Wilbrink; Lubbert Dijkhuizen; M Petrusma; Robert van der Geize
FadD19 of Rhodococcus rhodochrous DSM43269, a steroid-coenzyme A ligase essential for degradation of C-24 branched sterol side chains.
Applied and environmental microbiology 2011;77(13):4455-64.
2011: Marta Palomo; Tjaard Pijning; Thijs Booiman; Justyna Malgorzata Dobruchowska; Jeroen van der Vlist; Slavko Kralj; Antoni Planas; Katja Loos; Johannis P Kamerling; Bauke W Dijkstra; M J E C van der Maarel; Lubbert Dijkhuizen; Hans Leemhuis
Thermus thermophilus glycoside hydrolase family 57 branching enzyme: crystal structure, mechanism of action, and products formed.
The Journal of biological chemistry 2011;286(5):3520-30.
2011: Patrick Hill; Václav Krištůfek; Lubbert Dijkhuizen; Christopher Boddy; David Kroetsch; Jan Dirk van Elsas
Land use intensity controls actinobacterial community structure.
Microbial ecology 2011;61(2):286-302.
2010: Andreja Vujicic-Zagar; Tjaard Pijning; Slavko Kralj; Cesar A López; Wieger Eeuwema; Lubbert Dijkhuizen; Bauke W Dijkstra
Crystal structure of a 117 kDa glucansucrase fragment provides insight into evolution and product specificity of GH70 enzymes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21406-11.
2010: Stefan Kol; M Elena Merlo; Richard A Scheltema; Marcel de Vries; roel vonk; Niels A Kikkert; Lubbert Dijkhuizen; Rainer Breitling; Eriko Takano
Metabolomic characterization of the salt stress response in Streptomyces coelicolor.
Applied and environmental microbiology 2010;76(8):2574-81.
2010: Munir A Anwar; Slavko Kralj; Anna Villar Piqué; Hans Leemhuis; M J E C van der Maarel; Lubbert Dijkhuizen
Inulin and levan synthesis by probiotic Lactobacillus gasseri strains: characterization of three novel fructansucrase enzymes and their fructan products.
Microbiology (Reading, England) 2010;156(Pt 4):1264-74.
2010: Hans Leemhuis; Ronan M Kelly; Lubbert Dijkhuizen
Engineering of cyclodextrin glucanotransferases and the impact for biotechnological applications.
Applied microbiology and biotechnology 2010;85(4):823-35.
2009: Kamila Z Rosłoniec; Maarten H Wilbrink; Jenna K Capyk; William W Mohn; Martin Ostendorf; Robert van der Geize; Lubbert Dijkhuizen; Lindsay D Eltis
Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1.
Molecular microbiology 2009;74(5):1031-43.
2009: Amarila Malik; Maksum Radji; Slavko Kralj; Lubbert Dijkhuizen
Screening of lactic acid bacteria from Indonesia reveals glucansucrase and fructansucrase genes in two different Weissella confusa strains from soya.
FEMS microbiology letters 2009;300(1):131-8.
2009: Wouter de Jong; Han A B Wösten; Lubbert Dijkhuizen; Dennis Claessen
Attachment of Streptomyces coelicolor is mediated by amyloidal fimbriae that are anchored to the cell surface via cellulose.
Molecular microbiology 2009;73(6):1128-40.
2009: M Petrusma; Lubbert Dijkhuizen; Robert van der Geize
Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity.
Applied and environmental microbiology 2009;75(16):5300-7.
2009: Ronan M Kelly; Lubbert Dijkhuizen; Hans Leemhuis
The evolution of cyclodextrin glucanotransferase product specificity.
Applied microbiology and biotechnology 2009;84(1):119-33.
2009: Ronan M Kelly; Lubbert Dijkhuizen; Hans Leemhuis
Starch and alpha-glucan acting enzymes, modulating their properties by directed evolution.
Journal of biotechnology 2009;140(3-4):184-93.
2009: Sander S van Leeuwen; Slavko Kralj; Wieger Eeuwema; Gerrit J Gerwig; Lubbert Dijkhuizen; Johannis P Kamerling
Structural characterization of bioengineered alpha-D-glucans produced by mutant glucansucrase GTF180 enzymes of Lactobacillus reuteri strain 180.
Biomacromolecules 2009;10(3):580-8.
2009: Wouter de Jong; Angel Manteca; Jesus Sanchez; Giselda Bucca; Colin P Smith; Lubbert Dijkhuizen; Dennis Claessen; Han A B Wösten
NepA is a structural cell wall protein involved in maintenance of spore dormancy in Streptomyces coelicolor.
Molecular microbiology 2009;71(6):1591-603.
2009: Hans Leemhuis; Ronan M Kelly; Lubbert Dijkhuizen
Directed evolution of enzymes: Library screening strategies.
IUBMB life 2009;61(3):222-8.
2009: M Palomo; Slavko Kralj; M J E C van der Maarel; Lubbert Dijkhuizen
The unique branching patterns of Deinococcus glycogen branching enzymes are determined by their N-terminal domains.
Applied and environmental microbiology 2009;75(5):1355-62.
2008: William W Mohn; Robert van der Geize; Gordon R Stewart; Sachi Okamoto; Jie Liu; Lubbert Dijkhuizen; Lindsay D Eltis
The actinobacterial mce4 locus encodes a steroid transporter.
The Journal of biological chemistry 2008;283(51):35368-74.
2008: Slavko Kralj; Sander S van Leeuwen; Vincent Valk; Wieger Eeuwema; Johannis P Kamerling; Lubbert Dijkhuizen
Hybrid reuteransucrase enzymes reveal regions important for glucosidic linkage specificity and the transglucosylation/hydrolysis ratio.
The FEBS journal 2008;275(23):6002-10.
2008: R van der Geize; W de Jong; G I Hessels; A W F Grommen; A A C Jacobs; Lubbert Dijkhuizen
A novel method to generate unmarked gene deletions in the intracellular pathogen Rhodococcus equi using 5-fluorocytosine conditional lethality.
Nucleic acids research 2008;36(22):e151.
2008: Robert van der Geize; Gerda I Hessels; M Nienhuis-Kuiper; Lubbert Dijkhuizen
Characterization of a second Rhodococcus erythropolis SQ1 3-ketosteroid 9alpha-hydroxylase activity comprising a terminal oxygenase homologue, KshA2, active with oxygenase-reductase component KshB.
Applied and environmental microbiology 2008;74(23):7197-203.
2008: Irina Borodina; Jeroen Siebring; Jie Zhang; Colin P Smith; Geertje van Keulen; Lubbert Dijkhuizen; Jens Nielsen
Antibiotic overproduction in Streptomyces coelicolor A3 2 mediated by phosphofructokinase deletion.
The Journal of biological chemistry 2008;283(37):25186-99.
2008: Nicolien F Wieringa; H J van der Windt; R R M Zuiker; Lubbert Dijkhuizen; Marian Verkerk; R J Vonk; J A A Swart
Positioning functional foods in an ecological approach to the prevention of overweight and obesity.
Obesity reviews : an official journal of the International Association for the Study of Obesity 2008;9(5):464-73.
2008: Sander S van Leeuwen; Slavko Kralj; Gerrit J Gerwig; Lubbert Dijkhuizen; Johannis P Kamerling
Structural analysis of bioengineered alpha-D-glucan produced by a triple mutant of the Glucansucrase GTF180 enzyme from Lactobacillus reuteri strain 180: generation of (alpha1-->4) linkages in a native (1-->3)(1-->6)-alpha-D-glucan.
Biomacromolecules 2008;9(8):2251-8.
2008: Ronan M Kelly; Hans Leemhuis; Henriëtte J Rozeboom; Niels van Oosterwijk; Bauke W Dijkstra; Lubbert Dijkhuizen
Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution.
The Biochemical journal 2008;413(3):517-25.
2008: Hendrik Hellmuth; Sabine Wittrock; Slavko Kralj; Lubbert Dijkhuizen; Bernd Hofer; Jürgen Seibel
Engineering the glucansucrase GTFR enzyme reaction and glycosidic bond specificity: toward tailor-made polymer and oligosaccharide products.
Biochemistry 2008;47(25):6678-84.
2008: Evelien M te Poele; Henk Bolhuis; Lubbert Dijkhuizen
Actinomycete integrative and conjugative elements.
Antonie van Leeuwenhoek 2008;94(1):127-43.
2008: Munir A Anwar; Slavko Kralj; M J E C van der Maarel; Lubbert Dijkhuizen
The probiotic Lactobacillus johnsonii NCC 533 produces high-molecular-mass inulin from sucrose by using an inulosucrase enzyme.
Applied and environmental microbiology 2008;74(11):3426-33.
2008: Xiao-Lian Yuan; Rachel M van der Kaaij; Cees A M J J van den Hondel; Peter J Punt; M J E C van der Maarel; Lubbert Dijkhuizen; Arthur F J Ram
Aspergillus niger genome-wide analysis reveals a large number of novel alpha-glucan acting enzymes with unexpected expression profiles.
Molecular genetics and genomics : MGG 2008;279(6):545-61.
2008: Sander S van Leeuwen; Slavko Kralj; Ineke H van Geel-Schutten; Gerrit J Gerwig; Lubbert Dijkhuizen; Johannis P Kamerling
Structural analysis of the alpha-D-glucan (EPS35-5) produced by the Lactobacillus reuteri strain 35-5 glucansucrase GTFA enzyme.
Carbohydrate research 2008;343(7):1251-65.
2008: Sander S van Leeuwen; Slavko Kralj; Ineke H van Geel-Schutten; Gerrit J Gerwig; Lubbert Dijkhuizen; Johannis P Kamerling
Structural analysis of the alpha-D-glucan (EPS180) produced by the Lactobacillus reuteri strain 180 glucansucrase GTF180 enzyme.
Carbohydrate research 2008;343(7):1237-50.
2008: Evelien M te Poele; Markiyan Samborskyy; Markiyan Oliynyk; Peter F Leadlay; Henk Bolhuis; Lubbert Dijkhuizen
Actinomycete integrative and conjugative pMEA-like elements of Amycolatopsis and Saccharopolyspora decoded.
Plasmid 2008;59(3):202-16.
2008: Ronan M Kelly; Hans Leemhuis; Linda Gätjen; Lubbert Dijkhuizen
Evolution toward small molecule inhibitor resistance affects native enzyme function and stability, generating acarbose-insensitive cyclodextrin glucanotransferase variants.
The Journal of biological chemistry 2008;283(16):10727-34.
2008: Jan Knol; Karin Bodewits; Gerda I Hessels; Lubbert Dijkhuizen; Robert van der Geize
3-Keto-5alpha-steroid Delta(1)-dehydrogenase from Rhodococcus erythropolis SQ1 and its orthologue in Mycobacterium tuberculosis H37Rv are highly specific enzymes that function in cholesterol catabolism.
The Biochemical journal 2008;410(2):339-46.
2007: R M van der Kaaij; S Janecek; M J E C van der Maarel; Lubbert Dijkhuizen
Phylogenetic and biochemical characterization of a novel cluster of intracellular fungal alpha-amylase enzymes.
Microbiology (Reading, England) 2007;153(Pt 12):4003-15.
2007: Ali Rohman; Niels van Oosterwijk; Slavko Kralj; Lubbert Dijkhuizen; Bauke W Dijkstra; Ni Nyoman Tri Puspaningsih
Purification, crystallization and preliminary X-ray analysis of a thermostable glycoside hydrolase family 43 beta-xylosidase from Geobacillus thermoleovorans IT-08.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 11):932-5.
2007: Ronan M Kelly; Hans Leemhuis; Lubbert Dijkhuizen
Conversion of a cyclodextrin glucanotransferase into an alpha-amylase: assessment of directed evolution strategies.
Biochemistry 2007;46(39):11216-22.
2007: Evelien M te Poele; Marrit N Habets; Geok Tan; Alan C Ward; Michael Goodfellow; Henk Bolhuis; Lubbert Dijkhuizen
Prevalence and distribution of nucleotide sequences typical for pMEA-like accessory genetic elements in the genus Amycolatopsis.
FEMS microbiology ecology 2007;61(2):285-94.
2007: R M van der Kaaij; Xiao-Lian Yuan; Angelique C. Franken; Arthur F J Ram; Peter J Punt; M J E C van der Maarel; Lubbert Dijkhuizen
Two novel, putatively cell wall-associated and glycosylphosphatidylinositol-anchored alpha-glucanotransferase enzymes of Aspergillus niger.
Eukaryotic cell 2007;6(7):1178-88.
2007: Thomas R M Barends; Jelle B Bultema; Thijs Kaper; M J E C van der Maarel; Lubbert Dijkhuizen; Bauke W Dijkstra
Three-way stabilization of the covalent intermediate in amylomaltase, an alpha-amylase-like transglycosylase.
The Journal of biological chemistry 2007;282(23):17242-9.
2007: Thijs Kaper; Hans Leemhuis; Joost C M Uitdehaag; Bart A van der Veen; Bauke W Dijkstra; M J E C van der Maarel; Lubbert Dijkhuizen
Identification of acceptor substrate binding subsites +2 and +3 in the amylomaltase from Thermus thermophilus HB8.
Biochemistry 2007;46(17):5261-9.
2007: Coenie Goosen; Xiao-Lian Yuan; Jolanda M van Munster; Arthur F J Ram; M J E C van der Maarel; Lubbert Dijkhuizen
Molecular and biochemical characterization of a novel intracellular invertase from Aspergillus niger with transfructosylating activity.
Eukaryotic cell 2007;6(4):674-81.
2007: Rebekka Biedendieck; Rafael Beine; Martin Gamer; Eva Jordan; Klaus Buchholz; Jürgen Seibel; Lubbert Dijkhuizen; Marco Malten; Dieter Jahn
Export, purification, and activities of affinity tagged Lactobacillus reuteri levansucrase produced by Bacillus megaterium.
Applied microbiology and biotechnology 2007;74(5):1062-73.
2007: Hendrik Hellmuth; Lars Hillringhaus; Sven Höbbel; Slavko Kralj; Lubbert Dijkhuizen; Jürgen Seibel
Highly efficient chemoenzymatic synthesis of novel branched thiooligosaccharides by substrate direction with glucansucrases.
Chembiochem : a European journal of chemical biology 2007;8(3):273-6.
2007: Robert van der Geize; Katherine Yam; Thomas Heuser; Maarten H Wilbrink; Hirofumi Hara; Matthew C Anderton; Edith Sim; Lubbert Dijkhuizen; Julian E Davies; William W Mohn; Lindsay D Eltis
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1947-52.
2007: Herman J Pel; Johannes H de Winde; David B Archer; Paul S Dyer; Gerald Hofmann; Peter J Schaap; Geoffrey Turner; Ronald P de Vries; Richard Albang; Kaj Albermann; Mikael R Andersen; Jannick D Bendtsen; Jacques A E Benen; Marco van den Berg; Stefaan Breestraat; Mark X Caddick; Roland Contreras; Michael Cornell; Pedro M Coutinho; Etienne G J Danchin; Alfons J M Debets; Peter Dekker; Piet W M van Dijck; Alard van Dijk; Lubbert Dijkhuizen; Arnold J M Driessen; Christophe d'Enfert; Steven Geysens; Coenie Goosen; Gert S P Groot; Piet W J de Groot; Thomas Guillemette; Bernard Henrissat; Marga Herweijer; Johannes P T W van den Hombergh; Cees A M J J van den Hondel; Rene T J M van der Heijden; Rachel M van der Kaaij; Frans Klis; Harrie J Kools; Christian P Kubicek; Patricia A van Kuyk; Jürgen Lauber; Xin Lu; Marc J E C van der Maarel; Rogier Meulenberg; Hildegard Menke; Martin A Mortimer; Jens Nielsen; Stephen G Oliver; Maurien Olsthoorn; Karoly Pal; Noël N M E van Peij; Arthur F J Ram; Ursula Rinas; Hans Roubos; cees sagt; Monika Schmoll; Jibin Sun; David Ussery; Janos Varga; Wouter Vervecken; Peter J J van de Vondervoort; Holger Wedler; Han A B Wösten; An-Ping Zeng; Albert J J van Ooyen; Jaap Visser; Hein Stam
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88.
Nature biotechnology 2007;25(2):221-31.
2006: Xiao-Lian Yuan; Coenie Goosen; Harrie Kools; M J E C van der Maarel; Cees A M J J van den Hondel; Lubbert Dijkhuizen; Arthur F J Ram
Database mining and transcriptional analysis of genes encoding inulin-modifying enzymes of Aspergillus niger.
Microbiology (Reading, England) 2006;152(Pt 10):3061-73.
2006: Evelien M te Poele; Harm Kloosterman; Gerda I Hessels; Henk Bolhuis; Lubbert Dijkhuizen
RepAM of the Amycolatopsis methanolica integrative element pMEA300 belongs to a novel class of replication initiator proteins.
Microbiology (Reading, England) 2006;152(Pt 10):2943-50.
2006: Lukasz K Ozimek; Slavko Kralj; Thijs Kaper; M J E C van der Maarel; Lubbert Dijkhuizen
Single amino acid residue changes in subsite -1 of inulosucrase from Lactobacillus reuteri 121 strongly influence the size of products synthesized.
The FEBS journal 2006;273(17):4104-13.
2006: Slavko Kralj; Wieger Eeuwema; Tom H Eckhardt; Lubbert Dijkhuizen
Role of asparagine 1134 in glucosidic bond and transglycosylation specificity of reuteransucrase from Lactobacillus reuteri 121.
The FEBS journal 2006;273(16):3735-42.
2006: Dennis Claessen; Wouter de Jong; Lubbert Dijkhuizen; Han A B Wösten
Regulation of Streptomyces development: reach for the sky!
Trends in microbiology 2006;14(7):313-9.
2006: Lukasz K Ozimek; Slavko Kralj; M J E C van der Maarel; Lubbert Dijkhuizen
The levansucrase and inulosucrase enzymes of Lactobacillus reuteri 121 catalyse processive and non-processive transglycosylation reactions.
Microbiology (Reading, England) 2006;152(Pt 4):1187-96.
2006: Sacha A F T van Hijum; Slavko Kralj; Lukasz K Ozimek; Lubbert Dijkhuizen; Ineke G H van Geel-Schutten
Structure-function relationships of glucansucrase and fructansucrase enzymes from lactic acid bacteria.
Microbiology and molecular biology reviews : MMBR 2006;70(1):157-76.
2006: Sung A Schoondermark-Stolk; Michael Jansen; Janine H Veurink; Arie J Verkleij; C Theo Verrips; Gert-Jan W Euverink; Johannes Boonstra; Lubbert Dijkhuizen
Rapid identification of target genes for 3-methyl-1-butanol production in Saccharomyces cerevisiae.
Applied microbiology and biotechnology 2006;70(2):237-46.
2006: Marco Malten; Rebekka Biedendieck; Martin Gamer; Ann-Christin Drews; Simon Stammen; Klaus Buchholz; Lubbert Dijkhuizen; Dieter Jahn
A Bacillus megaterium plasmid system for the production, export, and one-step purification of affinity-tagged heterologous levansucrase from growth medium.
Applied and environmental microbiology 2006;72(2):1677-9.
2005: Thijs Kaper; Boguslawa Talik; Thijs J Ettema; Herman Bos; M J E C van der Maarel; Lubbert Dijkhuizen
Amylomaltase of Pyrobaculum aerophilum IM2 produces thermoreversible starch gels.
Applied and environmental microbiology 2005;71(9):5098-106.
2005: Geertje van Keulen; David A Hopwood; Lubbert Dijkhuizen; R Gary Sawers
Gas vesicles in actinomycetes: old buoys in novel habitats?
Trends in microbiology 2005;13(8):350-4.
2005: Slavko Kralj; E Stripling; P Sanders; GH van Geel-Schutten; Lubbert Dijkhuizen
Highly hydrolytic reuteransucrase from probiotic Lactobacillus reuteri strain ATCC 55730.
Applied and environmental microbiology 2005;71(7):3942-50.
2005: Slavko Kralj; Ineke G H van Geel-Schutten; Elly J Faber; M J E C van der Maarel; Lubbert Dijkhuizen
Rational transformation of Lactobacillus reuteri 121 reuteransucrase into a dextransucrase.
Biochemistry 2005;44(25):9206-16.
2005: Martijn F B G Gebbink; Dennis Claessen; Barend Bouma; Lubbert Dijkhuizen; Han A B Wösten
Amyloids--a functional coat for microorganisms.
Nature reviews. Microbiology 2005;3(4):333-41.
2005: Lukasz K Ozimek; Gert-Jan W Euverink; M J E C van der Maarel; Lubbert Dijkhuizen
Mutational analysis of the role of calcium ions in the Lactobacillus reuteri strain 121 fructosyltransferase (levansucrase and inulosucrase) enzymes.
FEBS letters 2005;579(5):1124-8.
2004: Slavko Kralj; GH van Geel-Schutten; M M G Dondorff; S Kirsanovs; M J E C van der Maarel; Lubbert Dijkhuizen
Glucan synthesis in the genus Lactobacillus: isolation and characterization of glucansucrase genes, enzymes and glucan products from six different strains.
Microbiology (Reading, England) 2004;150(Pt 11):3681-90.
2004: Hans Leemhuis; Udo F Wehmeier; Lubbert Dijkhuizen
Single amino acid mutations interchange the reaction specificities of cyclodextrin glycosyltransferase and the acarbose-modifying enzyme acarviosyl transferase.
Biochemistry 2004;43(41):13204-13.
2004: Slavko Kralj; GH van Geel-Schutten; M J E C van der Maarel; Lubbert Dijkhuizen
Biochemical and molecular characterization of Lactobacillus reuteri 121 reuteransucrase.
Microbiology (Reading, England) 2004;150(Pt 7):2099-112.
2004: Dennis Claessen; Ietse Stokroos; Heine J Deelstra; Nynke A Penninga; Christiane Bormann; JOSE SALAS; Lubbert Dijkhuizen; Han A B Wösten
The formation of the rodlet layer of streptomycetes is the result of the interplay between rodlins and chaplins.
Molecular microbiology 2004;53(2):433-43.
2004: Geertje van Keulen; Jeroen Siebring; Krzysztof Przemysław Rembacz; Martin Hoogeveen; Magdalena Tomczynska; Lubbert Dijkhuizen
Improved method for the isolation of RNA from (standing liquid cultures of) Streptomycetes.
Journal of microbiological methods 2004;58(1):139-42.
2004: Robert van der Geize; Lubbert Dijkhuizen
Harnessing the catabolic diversity of rhodococci for environmental and biotechnological applications.
Current opinion in microbiology 2004;7(3):255-61.
2004: Meike I Janssen; M B M van Leeuwen; Theo G van Kooten; J de Vries; Lubbert Dijkhuizen; Han A B Wösten
Promotion of fibroblast activity by coating with hydrophobins in the beta-sheet end state.
Biomaterials 2004;25(14):2731-9.
2004: Thijs Kaper; M J E C van der Maarel; Gert-Jan W Euverink; Lubbert Dijkhuizen
Exploring and exploiting starch-modifying amylomaltases from thermophiles.
Biochemical Society transactions 2004;32(Pt 2):279-82.
2004: Sacha A F T van Hijum; E Szalowska; M J E C van der Maarel; Lubbert Dijkhuizen
Biochemical and molecular characterization of a levansucrase from Lactobacillus reuteri.
Microbiology (Reading, England) 2004;150(Pt 3):621-30.
2004: Lukasz K Ozimek; Sacha A F T van Hijum; Gerrit A van Koningsveld; M J E C van der Maarel; GH van Geel-Schutten; Lubbert Dijkhuizen
Site-directed mutagenesis study of the three catalytic residues of the fructosyltransferases of Lactobacillus reuteri 121.
FEBS letters 2004;560(1-3):131-3.
2004: Hans Leemhuis; Henriëtte J Rozeboom; Bauke W Dijkstra; Lubbert Dijkhuizen
Improved thermostability of bacillus circulans cyclodextrin glycosyltransferase by the introduction of a salt bridge.
Proteins 2004;54(1):128-34.
2004: Margherita Sosio; Harm Kloosterman; Alessandra Bianchi; Peter de Vreugd; Lubbert Dijkhuizen; Stefano Donadio
Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.
Microbiology (Reading, England) 2004;150(Pt 1):95-102.
2003: Harm Kloosterman; Gerda I Hessels; Jan W Vrijbloed; Gert-Jan W Euverink; Lubbert Dijkhuizen
(De)regulation of key enzyme steps in the shikimate pathway and phenylalanine-specific pathway of the actinomycete Amycolatopsis methanolica.
Microbiology (Reading, England) 2003;149(Pt 11):3321-30.
2003: Hans Leemhuis; Gert-Jan W Euverink; Lubbert Dijkhuizen
High-throughput screening for gene libraries expressing carbohydrate hydrolase activity.
Biotechnology letters 2003;25(19):1643-5.
2003: Hans Leemhuis; Karsten M Kragh; Bauke W Dijkstra; Lubbert Dijkhuizen
Engineering cyclodextrin glycosyltransferase into a starch hydrolase with a high exo-specificity.
Journal of biotechnology 2003;103(3):203-12.
2003: Dennis Claessen; Rick Rink; Wouter de Jong; Jeroen Siebring; Peter de Vreugd; F G Hidde Boersma; Lubbert Dijkhuizen; Han A B Wosten
A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils.
Genes & development 2003;17(14):1714-26.
2003: Hans Leemhuis; Henriëtte J Rozeboom; Maarten Wilbrink; Gert-Jan W Euverink; Bauke W Dijkstra; Lubbert Dijkhuizen
Conversion of cyclodextrin glycosyltransferase into a starch hydrolase by directed evolution: the role of alanine 230 in acceptor subsite +1.
Biochemistry 2003;42(24):7518-26.
2003: Michael Jansen; Janine H Veurink; Gert-Jan W Euverink; Lubbert Dijkhuizen
Growth of the salt-tolerant yeast Zygosaccharomyces rouxii in microtiter plates: effects of NaCl, pH and temperature on growth and fusel alcohol production from branched-chain amino acids.
FEMS yeast research 2003;3(3):313-8.
2003: Hans Leemhuis; Henriëtte J Rozeboom; Bauke W Dijkstra; Lubbert Dijkhuizen
The fully conserved Asp residue in conserved sequence region I of the alpha-amylase family is crucial for the catalytic site architecture and activity.
FEBS letters 2003;541(1-3):47-51.
2003: Geertje van Keulen; Henk M Jonkers; Dennis Claessen; Lubbert Dijkhuizen; Han A B Wösten
Differentiation and anaerobiosis in standing liquid cultures of Streptomyces coelicolor.
Journal of bacteriology 2003;185(4):1455-8.
2003: Geertje van Keulen; Anja N J A Ridder; Lubbert Dijkhuizen; Wim G Meijer
Analysis of DNA binding and transcriptional activation by the LysR-type transcriptional regulator CbbR of Xanthobacter flavus.
Journal of bacteriology 2003;185(4):1245-52.
2003: Sacha A F T van Hijum; M J E C van der Maarel; Lubbert Dijkhuizen
Kinetic properties of an inulosucrase from Lactobacillus reuteri 121.
FEBS letters 2003;534(1-3):207-10.
2003: Hans Leemhuis; Bauke W Dijkstra; Lubbert Dijkhuizen
Thermoanaerobacterium thermosulfurigenes cyclodextrin glycosyltransferase.
European journal of biochemistry / FEBS 2003;270(1):155-62.
2002: Harm J Hektor; Harm Kloosterman; Lubbert Dijkhuizen
Identification of a magnesium-dependent NAD(P)(H)-binding domain in the nicotinoprotein methanol dehydrogenase from Bacillus methanolicus.
The Journal of biological chemistry 2002;277(49):46966-73.
2002: Meike I Janssen; M B M van Leeuwen; Karin Scholtmeijer; Theo G van Kooten; Lubbert Dijkhuizen; Han A B Wösten
Coating with genetic engineered hydrophobin promotes growth of fibroblasts on a hydrophobic solid.
Biomaterials 2002;23(24):4847-54.
2002: Robert van der Geize; Gerda I Hessels; Lubbert Dijkhuizen
Molecular and functional characterization of the kstD2 gene of Rhodococcus erythropolis SQ1 encoding a second 3-ketosteroid Delta(1)-dehydrogenase isoenzyme.
Microbiology (Reading, England) 2002;148(Pt 10):3285-92.
2002: Harm Kloosterman; Jan W Vrijbloed; Lubbert Dijkhuizen
Molecular, biochemical, and functional characterization of a Nudix hydrolase protein that stimulates the activity of a nicotinoprotein alcohol dehydrogenase.
The Journal of biological chemistry 2002;277(38):34785-92.
2002: Sacha A F T van Hijum; GH van Geel-Schutten; H Rahaoui; M J E C van der Maarel; Lubbert Dijkhuizen
Characterization of a novel fructosyltransferase from Lactobacillus reuteri that synthesizes high-molecular-weight inulin and inulin oligosaccharides.
Applied and environmental microbiology 2002;68(9):4390-8.
2002: Slavko Kralj; GH van Geel-Schutten; H Rahaoui; R J Leer; E J Faber; M J E C van der Maarel; Lubbert Dijkhuizen
Molecular characterization of a novel glucosyltransferase from Lactobacillus reuteri strain 121 synthesizing a unique, highly branched glucan with alpha-(1-->4) and alpha-(1-->6) glucosidic bonds.
Applied and environmental microbiology 2002;68(9):4283-91.
2002: Robert van der Geize; Gerda I Hessels; R van Gerwen; P van Der Meijden; Lubbert Dijkhuizen
Molecular and functional characterization of kshA and kshB, encoding two components of 3-ketosteroid 9alpha-hydroxylase, a class IA monooxygenase, in Rhodococcus erythropolis strain SQ1.
Molecular microbiology 2002;45(4):1007-18.
2002: Dennis Claessen; Han A B Wösten; Geertje van Keulen; Onno G Faber; Alexandra M C R Alves; Wim G Meijer; Lubbert Dijkhuizen
Two novel homologous proteins of Streptomyces coelicolor and Streptomyces lividans are involved in the formation of the rodlet layer and mediate attachment to a hydrophobic surface.
Molecular microbiology 2002;44(6):1483-92.
2002: M J E C van der Maarel; Bart A van der Veen; Joost C M Uitdehaag; Hans Leemhuis; Lubbert Dijkhuizen
Properties and applications of starch-converting enzymes of the alpha-amylase family.
Journal of biotechnology 2002;94(2):137-55.
2002: Hans Leemhuis; Bauke W Dijkstra; Lubbert Dijkhuizen
Mutations converting cyclodextrin glycosyltransferase from a transglycosylase into a starch hydrolase.
FEBS letters 2002;514(2-3):189-92.
2002: Hans Leemhuis; Joost C M Uitdehaag; Henriëtte J Rozeboom; Bauke W Dijkstra; Lubbert Dijkhuizen
The remote substrate binding subsite -6 in cyclodextrin-glycosyltransferase controls the transferase activity of the enzyme via an induced-fit mechanism.
The Journal of biological chemistry 2002;277(2):1113-9.
2001: Sacha A F T van Hijum; K Bonting; M J E C van der Maarel; Lubbert Dijkhuizen
Purification of a novel fructosyltransferase from Lactobacillus reuteri strain 121 and characterization of the levan produced.
FEMS microbiology letters 2001;205(2):323-8.
2001: Robert van der Geize; Gerda I Hessels; R van Gerwen; P van Der Meijden; Lubbert Dijkhuizen
Unmarked gene deletion mutagenesis of kstD, encoding 3-ketosteroid Delta1-dehydrogenase, in Rhodococcus erythropolis SQ1 using sacB as counter-selectable marker.
FEMS microbiology letters 2001;205(2):197-202.
2001: Alexandra M C R Alves; Gert-Jan W Euverink; Helena Santos; Lubbert Dijkhuizen
Different physiological roles of ATP- and PP(i)-dependent phosphofructokinase isoenzymes in the methylotrophic actinomycete Amycolatopsis methanolica.
Journal of bacteriology 2001;183(24):7231-40.
2001: Bart A van der Veen; Hans Leemhuis; Slavko Kralj; Joost C M Uitdehaag; Bauke W Dijkstra; Lubbert Dijkhuizen
Hydrophobic amino acid residues in the acceptor binding site are main determinants for reaction mechanism and specificity of cyclodextrin-glycosyltransferase.
The Journal of biological chemistry 2001;276(48):44557-62.
2001: Joost C M Uitdehaag; Bart A van der Veen; Lubbert Dijkhuizen; R Elber; Bauke W Dijkstra
Enzymatic circularization of a malto-octaose linear chain studied by stochastic reaction path calculations on cyclodextrin glycosyltransferase.
Proteins 2001;43(3):327-35.
2000: Joost C M Uitdehaag; Bauke W Dijkstra; Lubbert Dijkhuizen
Engineering of cyclodextrin glycosyltransferase reaction and product specificity.
Biochimica et biophysica acta 2000;1543(2):336-360.
2000: Geertje van Keulen; Lubbert Dijkhuizen; Wim G Meijer
Effects of the Calvin cycle on nicotinamide adenine dinucleotide concentrations and redox balances of Xanthobacter flavus.
Journal of bacteriology 2000;182(16):4637-9.
2000: Joost C M Uitdehaag; GJ van Alebeek; Bart A van der Veen; Lubbert Dijkhuizen; Bauke W Dijkstra
Structures of maltohexaose and maltoheptaose bound at the donor sites of cyclodextrin glycosyltransferase give insight into the mechanisms of transglycosylation activity and cyclodextrin size specificity.
Biochemistry 2000;39(26):7772-80.
2000: Bart A van der Veen; Joost C M Uitdehaag; Bauke W Dijkstra; Lubbert Dijkhuizen
The role of arginine 47 in the cyclization and coupling reactions of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 implications for product inhibition and product specificity.
European journal of biochemistry / FEBS 2000;267(12):3432-41.
2000: Robert van der Geize; Gerda I Hessels; R van Gerwen; Jan W Vrijbloed; P van Der Meijden; Lubbert Dijkhuizen
Targeted disruption of the kstD gene encoding a 3-ketosteroid delta(1)-dehydrogenase isoenzyme of Rhodococcus erythropolis strain SQ1.
Applied and environmental microbiology 2000;66(5):2029-36.
2000: Bart A van der Veen; Joost C M Uitdehaag; D Penninga; GJ van Alebeek; L M Smith; Bauke W Dijkstra; Lubbert Dijkhuizen
Rational design of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 to increase alpha-cyclodextrin production.
Journal of molecular biology 2000;296(4):1027-38.
2000: Bart A van der Veen; GJ van Alebeek; Joost C M Uitdehaag; Bauke W Dijkstra; Lubbert Dijkhuizen
The three transglycosylation reactions catalyzed by cyclodextrin glycosyltransferase from Bacillus circulans (strain 251) proceed via different kinetic mechanisms.
European journal of biochemistry / FEBS 2000;267(3):658-65.
1999: Joost C M Uitdehaag; Kor H Kalk; Bart A van der Veen; Lubbert Dijkhuizen; Bauke W Dijkstra
The cyclization mechanism of cyclodextrin glycosyltransferase (CGTase) as revealed by a gamma-cyclodextrin-CGTase complex at 1.8-A resolution.
The Journal of biological chemistry 1999;274(49):34868-76.
1999: Joost C M Uitdehaag; R Mosi; Kor H Kalk; Bart A van der Veen; Lubbert Dijkhuizen; Stephen G Withers; Bauke W Dijkstra
X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the alpha-amylase family.
Nature structural biology 1999;6(5):432-6.
1998: M Breedveld; K Bonting; Lubbert Dijkhuizen
Mutational analysis of exopolysaccharide biosynthesis by Lactobacillus sakei 0-1.
FEMS microbiology letters 1998;169(2):241-9.
1998: RD Wind; R M Buitelaar; Lubbert Dijkhuizen
Engineering of factors determining alpha-amylase and cyclodextrin glycosyltransferase specificity in the cyclodextrin glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1.
European journal of biochemistry / FEBS 1998;253(3):598-605.
1998: RD Wind; Joost C M Uitdehaag; R M Buitelaar; Bauke W Dijkstra; Lubbert Dijkhuizen
Engineering of cyclodextrin product specificity and pH optima of the thermostable cyclodextrin glycosyltransferase from Thermoanaerobacterium thermosulfurigenes EM1.
The Journal of biological chemistry 1998;273(10):5771-9.
1998: Geertje van Keulen; L Girbal; E R van den Bergh; Lubbert Dijkhuizen; Wim G Meijer
The LysR-type transcriptional regulator CbbR controlling autotrophic CO2 fixation by Xanthobacter flavus is an NADPH sensor.
Journal of bacteriology 1998;180(6):1411-7.
1997: Leonid V Bystrykh; Natalia I Govorukhina; Lubbert Dijkhuizen; Johannis A Duine
Tetrazolium-dye-linked alcohol dehydrogenase of the methylotrophic actinomycete Amycolatopsis methanolica is a three-component complex.
European journal of biochemistry / FEBS 1997;247(1):280-7.
1997: N Arfman; Harm J Hektor; Leonid V Bystrykh; Natalia I Govorukhina; Lubbert Dijkhuizen; J Frank
Properties of an NAD(H)-containing methanol dehydrogenase and its activator protein from Bacillus methanolicus.
European journal of biochemistry / FEBS 1997;244(2):426-33.
1997: Alexandra M C R Alves; Gert-Jan W Euverink; M J Bibb; Lubbert Dijkhuizen
Identification of ATP-dependent phosphofructokinase as a regulatory step in the glycolytic pathway of the actinomycete Streptomyces coelicolor A3(2).
Applied and environmental microbiology 1997;63(3):956-61.
1996: D Penninga; Bart A van der Veen; R M Knegtel; S A van Hijum; Henriëtte J Rozeboom; Kor H Kalk; Bauke W Dijkstra; Lubbert Dijkhuizen
The raw starch binding domain of cyclodextrin glycosyltransferase from Bacillus circulans strain 251.
The Journal of biological chemistry 1996;271(51):32777-84.
1996: B Strokopytov; R M Knegtel; D Penninga; Henriëtte J Rozeboom; Kor H Kalk; Lubbert Dijkhuizen; Bauke W Dijkstra
Structure of cyclodextrin glycosyltransferase complexed with a maltononaose inhibitor at 2.6 angstrom resolution. Implications for product specificity.
Biochemistry 1996;35(13):4241-9.
1996: Leonid V Bystrykh; Miguel Angel Fernández-Moreno; J K Herrema; Francisco Malpartida; David A Hopwood; Lubbert Dijkhuizen
Production of actinorhodin-related "blue pigments" by Streptomyces coelicolor A3(2).
Journal of bacteriology 1996;178(8):2238-44.
1996: L M Smith; W G Meijer; Lubbert Dijkhuizen; P M Goodwin
A protein having similarity with methylmalonyl-CoA mutase is required for the assimilation of methanol and ethanol by Methylobacterium extorquens AM1.
Microbiology (Reading, England) 1996;142 ( Pt 3)():675-84.
1996: R M Knegtel; R D Wind; Henriëtte J Rozeboom; Kor H Kalk; R M Buitelaar; Lubbert Dijkhuizen; Bauke W Dijkstra
Crystal structure at 2.3 A resolution and revised nucleotide sequence of the thermostable cyclodextrin glycosyltransferase from Thermonanaerobacterium thermosulfurigenes EM1.
Journal of molecular biology 1996;256(3):611-22.
1996: E R van den Bergh; S C Baker; R J Raggers; Peter Terpstra; E C Woudstra; Lubbert Dijkhuizen; Wim G Meijer
Primary structure and phylogeny of the Calvin cycle enzymes transketolase and fructosebisphosphate aldolase of Xanthobacter flavus.
Journal of bacteriology 1996;178(3):888-93.
1996: A M Alves; Wim G Meijer; J W Vrijbloed; Lubbert Dijkhuizen
Characterization and phylogeny of the pfp gene of Amycolatopsis methanolica encoding PPi-dependent phosphofructokinase.
Journal of bacteriology 1996;178(1):149-55.
1995: R M Knegtel; B Strokopytov; D Penninga; O G Faber; Henriëtte J Rozeboom; Kor H Kalk; Lubbert Dijkhuizen; Bauke W Dijkstra
Crystallographic studies of the interaction of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 with natural substrates and products.
The Journal of biological chemistry 1995;270(49):29256-64.
1995: G J Euverink; G I Hessels; C Franke; Lubbert Dijkhuizen
Chorismate mutase and 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase of the methylotrophic actinomycete Amycolatopsis methanolica.
Applied and environmental microbiology 1995;61(11):3796-803.
1995: J W Vrijbloed; J van Hylckama Vlieg; N M van der Put; G I Hessels; Lubbert Dijkhuizen
Molecular cloning with a pMEA300-derived shuttle vector and characterization of the Amycolatopsis methanolica prephenate dehydratase gene.
Journal of bacteriology 1995;177(22):6666-9.
1995: J W Vrijbloed; N M van der Put; Lubbert Dijkhuizen
Identification and functional analysis of the transfer region of plasmid pMEA300 of the methylotrophic actinomycete Amycolatopsis methanolica.
Journal of bacteriology 1995;177(22):6499-505.
1995: J W Vrijbloed; M Jelínková; G I Hessels; Lubbert Dijkhuizen
Identification of the minimal replicon of plasmid pMEA300 of the methylotrophic actinomycete Amycolatopsis methanolica.
Molecular microbiology 1995;18(1):21-31.
1995: E R van den Bergh; T A van der Kooij; Lubbert Dijkhuizen; Wim G Meijer
Fructosebisphosphatase isoenzymes of the chemoautotroph Xanthobacter flavus.
Journal of bacteriology 1995;177(20):5860-4.
1995: J W Vrijbloed; J Madoń; Lubbert Dijkhuizen
Transformation of the methylotrophic actinomycete Amycolatopis methanolica with plasmid DNA: stimulatory effect of a pMEA300-encoded gene.
Plasmid 1995;34(2):96-104.
1995: G J Euverink; D J Wolters; Lubbert Dijkhuizen
Prephenate dehydratase of the actinomycete Amycolatopsis methanolica: purification and characterization of wild-type and deregulated mutant proteins.
The Biochemical journal 1995;308 ( Pt 1)():313-20.
1995: R D Wind; W Liebl; R M Buitelaar; D Penninga; A Spreinat; Lubbert Dijkhuizen; Hubert Bahl
Cyclodextrin formation by the thermostable alpha-amylase of Thermoanaerobacterium thermosulfurigenes EM1 and reclassification of the enzyme as a cyclodextrin glycosyltransferase.
Applied and environmental microbiology 1995;61(4):1257-65.
1995: D Penninga; B Strokopytov; Henriëtte J Rozeboom; C L Lawson; Bauke W Dijkstra; J Bergsma; Lubbert Dijkhuizen
Site-directed mutations in tyrosine 195 of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 affect activity and product specificity.
Biochemistry 1995;34(10):3368-76.
1995: B Strokopytov; D Penninga; Henriëtte J Rozeboom; Kor H Kalk; Lubbert Dijkhuizen; Bauke W Dijkstra
X-ray structure of cyclodextrin glycosyltransferase complexed with acarbose. Implications for the catalytic mechanism of glycosidases.
Biochemistry 1995;34(7):2234-40.
1994: J W Vrijbloed; J Madoń; Lubbert Dijkhuizen
A plasmid from the methylotrophic actinomycete Amycolatopsis methanolica capable of site-specific integration.
Journal of bacteriology 1994;176(22):7087-90.
1994: A M Alves; G J Euverink; H J Hektor; G I Hessels; Johan Van der Vlag; J W Vrijbloed; D Hondmann; J Visser; Lubbert Dijkhuizen
Enzymes of glucose and methanol metabolism in the actinomycete Amycolatopsis methanolica.
Journal of bacteriology 1994;176(22):6827-35.
1994: C L Lawson; R van Montfort; B Strokopytov; Henriëtte J Rozeboom; Kor H Kalk; G E de Vries; D Penninga; Lubbert Dijkhuizen; Bauke W Dijkstra
Nucleotide sequence and X-ray structure of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 in a maltose-dependent crystal form.
Journal of molecular biology 1994;236(2):590-600.
1993: H F Hermes; Theo Sonke; P J Peters; J A van Balken; Johan Kamphuis; Lubbert Dijkhuizen; E M Meijer
Purification and Characterization of an l-Aminopeptidase from Pseudomonas putida ATCC 12633.
Applied and environmental microbiology 1993;59(12):4330-4.
1993: E R van den Bergh; Lubbert Dijkhuizen; Wim G Meijer
CbbR, a LysR-type transcriptional activator, is required for expression of the autotrophic CO2 fixation enzymes of Xanthobacter flavus.
Journal of bacteriology 1993;175(19):6097-104.
1993: Leonid V Bystrykh; Janet Vonck; E F van Bruggen; J van Beeumen; Bart Samyn; Natalia I Govorukhina; N Arfman; Johannis A Duine; Lubbert Dijkhuizen
Electron microscopic analysis and structural characterization of novel NADP(H)-containing methanol: N,N'-dimethyl-4-nitrosoaniline oxidoreductases from the gram-positive methylotrophic bacteria Amycolatopsis methanolica and Mycobacterium gastri MB19.
Journal of bacteriology 1993;175(6):1814-22.
1992: F Robert Tabita; J L Gibson; B Bowien; Lubbert Dijkhuizen; W G Meijer
Uniform designation for genes of the Calvin-Benson-Bassham reductive pentose phosphate pathway of bacteria.
FEMS microbiology letters 1992;78(2-3):107-10.
1992: G J Euverink; G I Hessels; J W Vrijbloed; J R Coggins; Lubbert Dijkhuizen
Purification and characterization of a dual function 3-dehydroquinate dehydratase from Amycolatopsis methanolica.
Journal of general microbiology 1992;138(11):2449-57.
1992: Margaret M Attwood; N Arfman; R A Weusthuis; Lubbert Dijkhuizen
Purification and characterization of an NAD(+)-linked formaldehyde dehydrogenase from the facultative RuMP cycle methylotroph Arthrobacter P1.
Antonie van Leeuwenhoek 1992;62(3):201-7.
1992: G E de Vries; N Arfman; Peter Terpstra; Lubbert Dijkhuizen
Cloning, expression, and sequence analysis of the Bacillus methanolicus C1 methanol dehydrogenase gene.
Journal of bacteriology 1992;174(16):5346-53.
1992: N Arfman; Lubbert Dijkhuizen; G Kirchhof; W Ludwig; K H Schleifer; E S Bulygina; K M Chumakov; Natalia I Govorukhina; Y A Trotsenko; D White
Bacillus methanolicus sp. nov., a new species of thermotolerant, methanol-utilizing, endospore-forming bacteria.
International journal of systematic bacteriology 1992;42(3):439-45.
1992: H K Reding; G L Croes; Lubbert Dijkhuizen; Juergen Wiegel
Emendation of Xanthobacter flavus as a motile species.
International journal of systematic bacteriology 1992;42(2):309-11.
1992: N Arfman; K J de Vries; H R Moezelaar; Margaret M Attwood; G K Robinson; M van Geel; Lubbert Dijkhuizen
Environmental regulation of alcohol metabolism in thermotolerant methylotrophic Bacillus strains.
Archives of microbiology 1992;157(3):272-8.
1991: Leonid V Bystrykh; Lubbert Dijkhuizen; W Harder
Modification of flavin adenine dinucleotide in alcohol oxidase of the yeast Hansenula polymorpha.
Journal of general microbiology 1991;137(10):2381-6.
1991: N Arfman; J Van Beeumen; G E De Vries; W Harder; Lubbert Dijkhuizen
Purification and characterization of an activator protein for methanol dehydrogenase from thermotolerant Bacillus spp.
The Journal of biological chemistry 1991;266(6):3955-60.
1991: Janet Vonck; N Arfman; G E De Vries; J Van Beeumen; E F Van Bruggen; Lubbert Dijkhuizen
Electron microscopic analysis and biochemical characterization of a novel methanol dehydrogenase from the thermotolerant Bacillus sp. C1.
The Journal of biological chemistry 1991;266(6):3949-54.
1991: Wim G Meijer; A C Arnberg; H G Enequist; Peter Terpstra; M E Lidstrom; Lubbert Dijkhuizen
Identification and organization of carbon dioxide fixation genes in Xanthobacter flavus H4-14.
Molecular & general genetics : MGG 1991;225(2):320-30.
1990: Wim G Meijer; H G Enequist; Peter Terpstra; Lubbert Dijkhuizen
Nucleotide sequences of the genes encoding fructosebisphosphatase and phosphoribulokinase from Xanthobacter flavus H4-14.
Journal of general microbiology 1990;136(11):2225-30.
1990: C L Lawson; J Bergsma; P M Bruinenberg; G de Vries; Lubbert Dijkhuizen; Bauke W Dijkstra
Maltodextrin-dependent crystallization of cyclomaltodextrin glucanotransferase from Bacillus circulans.
Journal of molecular biology 1990;214(4):807-9.
1990: L de Boer; Lubbert Dijkhuizen; G Grobben; M Goodfellow; E Stackebrandt; J H Parlett; D Whitehead; D Witt
Amycolatopsis methanolica sp. nov., a facultatively methylotrophic actinomycete.
International journal of systematic bacteriology 1990;40(2):194-204.
1990: Wim G Meijer; L M Croes; B Jenni; L G Lehmicke; M E Lidstrom; Lubbert Dijkhuizen
Characterization of Xanthobacter strains H4-14 and 25a and enzyme profiles after growth under autotrophic and heterotrophic conditions.
Archives of microbiology 1990;153(4):360-7.
1990: N Arfman; Leonid V Bystrykh; Natalia I Govorukhina; Lubbert Dijkhuizen
3-Hexulose-6-phosphate synthase from thermotolerant methylotroph Bacillus C1.
Methods in enzymology 1990;188():391-7.
1990: N Arfman; Lubbert Dijkhuizen
Methanol dehydrogenase from thermotolerant methylotroph Bacillus C1.
Methods in enzymology 1990;188():223-6.
1989: L De Boer; J W Brouwer; C W Van Hassel; P R Levering; Lubbert Dijkhuizen
Nitrogen metabolism in the facultative methylotroph Arthrobacter P1 grown with various amines or ammonia as nitrogen sources.
Antonie van Leeuwenhoek 1989;56(3):221-32.
1989: N Arfman; E M Watling; W Clement; R J van Oosterwijk; G E de Vries; W Harder; Margaret M Attwood; Lubbert Dijkhuizen
Methanol metabolism in thermotolerant methylotrophic Bacillus strains involving a novel catabolic NAD-dependent methanol dehydrogenase as a key enzyme.
Archives of microbiology 1989;152(3):280-8.
1988: Wim G Meijer; Lubbert Dijkhuizen
Regulation of autotrophic metabolism in Pseudomonas oxalaticus OX1 wild-type and an isocitrate-lyase-deficient mutant.
Journal of general microbiology 1988;134(12):3231-7.
1985: D B Janssen; A Scheper; Lubbert Dijkhuizen; Bernard Witholt
Degradation of halogenated aliphatic compounds by Xanthobacter autotrophicus GJ10.
Applied and environmental microbiology 1985;49(3):673-7.
1984: Lubbert Dijkhuizen; W Harder; L de Boer; A van Boven; W Clement; S Bron; G Venema
Genetic manipulation of the restricted facultative methylotroph Hyphomicrobium X by the R-plasmid-mediated introduction of the Escherichia coli pdh genes.
Archives of microbiology 1984;139(4):311-8.
1984: Lubbert Dijkhuizen; W Harder
Current views on the regulation of autotrophic carbon dioxide fixation via the Calvin cycle in bacteria.
Antonie van Leeuwenhoek 1984;50(5-6):473-87.
1983: W Harder; Lubbert Dijkhuizen
Physiological responses to nutrient limitation.
Annual review of microbiology 1983;37():1-23.
1982: W Harder; Lubbert Dijkhuizen
Strategies of mixed substrate utilization in microorganisms.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1982;297(1088):459-80.
1978: Lubbert Dijkhuizen; M Knight; W Harder
Metabolic regulation in Pseudomonas oxalaticus OX1. Autotrophic and heterotrophic growth on mixed substrates.
Archives of microbiology 1978;116(1):77-83.
1978: M Knight; Lubbert Dijkhuizen; W Harder
Metabolic regulation in Pseudomonas oxalaticus OX1. Enzyme and coenzyme concentration changes during substrate transition experiments.
Archives of microbiology 1978;116(1):85-90.
1977: Lubbert Dijkhuizen; M Wiersma; W Harder
Energy production and growth of Pseudomonas oxalaticus OX1 on oxalate and formate.
Archives of microbiology 1977;115(2):229-36.
1977: Lubbert Dijkhuizen; L Groen; W Harder; W N Konings
Active transport of oxalate by Pseudomonas oxalaticus OX1.
Archives of microbiology 1977;115(2):223-7.
1975: Lubbert Dijkhuizen; W Harder
Substrate inhibition in Pseudomonas oxalaticus OX1: a kinetic study of growth inhibition by oxalate and formate using extended cultures.
Antonie van Leeuwenhoek 1975;41(2):135-46.